bigram

This is a table of type bigram and their frequencies. Use it to search & browse the list to learn more about your study carrel.

bigram	frequency
intensive care	5268
critically ill	3390
care unit	2939
mechanical ventilation	2712
ill patients	2465
critical care	2226
icu admission	1920
septic shock	1806
acute respiratory	1677
icu patients	1559
patients admitted	1525
risk factors	1425
respiratory failure	1150
hospital mortality	1000
respiratory distress	981
cardiac arrest	977
mean age	956
mortality rate	948
icu stay	910
brain injury	857
distress syndrome	835
two groups	827
severe sepsis	796
organ failure	777
apache ii	768
coronavirus disease	764
cohort study	751
care units	750
mechanically ventilated	729
mg kg	714
blood pressure	693
control group	673
observational study	671
health care	670
emergency department	664
statistically significant	662
acquired pneumonia	658
significantly higher	647
logistic regression	633
systematic review	609
critical illness	603
study period	588
adult patients	583
severe acute	569
author funder	563
granted medrxiv	563
significant difference	557
among patients	539
hospitalized patients	533
ventilated patients	530
copyright holder	524
university hospital	519
hospital stay	516
patients undergoing	515
respiratory syndrome	515
trauma patients	515
retrospective study	513
traumatic brain	512
patients receiving	509
cardiac surgery	508
lung injury	507
icu beds	504
patients received	501
version posted	499
novel coronavirus	499
ng ml	494
associated pneumonia	494
ml kg	486
one patient	476
patients treated	473
day mortality	460
significant differences	455
clinical characteristics	450
prospective study	448
risk factor	446
respiratory tract	445
high risk	444
doc id	440
cord uid	440
patients without	439
organ dysfunction	438
united states	437
septic patients	433
sofa score	432
mortality rates	430
renal failure	423
antibiotic therapy	422
present study	419
median age	417
years old	414
kidney injury	411
made available	409
ii score	409
clinical practice	408
care medicine	408
blood flow	407
icu mortality	402
severe covid	397
poor outcome	393
increased risk	393
acute kidney	393
factors associated	388
two patients	381
within hours	378
neurocritical care	378
hospital discharge	377
randomized controlled	376
subarachnoid hemorrhage	374
pao fio	373
renal replacement	373
arterial pressure	369
statistical analysis	367
inflammatory response	367
central venous	366
heart rate	364
consecutive patients	363
multivariate analysis	362
international license	359
mg dl	359
tidal volume	357
replacement therapy	356
cardiac output	354
pg ml	351
clinical outcomes	350
controlled trial	347
significantly lower	343
regression analysis	342
heart failure	334
primary outcome	333
arterial blood	333
performed using	331
adverse events	330
ct scan	322
hospital admission	321
least one	321
inclusion criteria	321
patients requiring	319
peer review	316
included patients	316
multiple organ	315
infection control	313
ischemic stroke	307
clinical trials	306
clinical trial	306
public health	306
prospective observational	303
staphylococcus aureus	303
blood samples	303
retrospective cohort	302
high mortality	298
mean arterial	298
invasive mechanical	293
oxygen saturation	292
informed consent	292
respiratory rate	292
infectious diseases	286
ards patients	284
icu discharge	283
reactive protein	281
higher mortality	280
clinical course	279
nosocomial infections	278
saps ii	274
status epilepticus	274
intracranial pressure	274
patient care	273
within days	272
medrxiv preprint	272
increased mortality	272
palliative care	269
first hours	268
clinical features	268
independently associated	267
infected patients	264
membrane oxygenation	264
blood cultures	261
icu length	261
elderly patients	257
significantly associated	255
year period	254
icu care	254
body weight	254
predictive value	253
odds ratio	253
pulmonary disease	253
patients hospitalized	252
invasive ventilation	252
glasgow coma	252
extracorporeal membrane	252
social distancing	248
airway pressure	248
syndrome coronavirus	244
lower respiratory	242
retrospective analysis	242
patients died	241
three patients	241
acute lung	241
patients presenting	238
medical center	238
ethics regulations	238
severe disease	237
sample size	236
kidney disease	234
first days	234
pulmonary embolism	232
functional outcome	231
long term	229
previous studies	226
data collection	225
clinical data	225
brain death	225
higher risk	225
case report	224
overall mortality	222
care patients	220
exclusion criteria	218
computed tomography	217
univariate analysis	216
per patient	216
medical records	212
prospective cohort	212
four patients	212
may also	211
mm hg	211
interquartile range	210
month period	210
myocardial infarction	210
case series	209
blood gas	209
platelet count	208
surgical patients	208
icu admissions	208
chronic obstructive	207
pseudomonas aeruginosa	207
therapeutic hypothermia	207
confidence interval	207
healthcare workers	206
intracerebral hemorrhage	203
pulmonary artery	203
acute renal	203
family members	203
tertiary care	203
patients may	202
per day	202
baseline characteristics	201
blood glucose	201
ml min	200
vital signs	199
respiratory support	198
year old	198
coma scale	197
prone positioning	196
demographic data	196
decision making	196
spontaneous breathing	196
cancer patients	196
rights reserved	196
significant increase	195
antibiotic treatment	195
regression model	193
determine whether	193
obstructive pulmonary	193
pressure support	193
disease severity	192
plasma levels	192
independent risk	191
nitric oxide	191
total number	191
median time	190
patients infected	190
antimicrobial therapy	190
age years	189
patients underwent	189
side effects	188
significantly different	187
ventilatory support	187
commonly used	187
five patients	186
patient population	186
data suggest	186
severe ards	186
acute phase	185
world health	185
hospital length	184
oxygen therapy	183
pilot study	183
chart review	182
patient outcomes	181
chain reaction	181
standard deviation	181
significantly increased	180
blood culture	180
statistical significance	180
group i	179
renal function	178
cerebral edema	178
average age	177
acute physiology	177
collected data	177
cardiac index	177
failure assessment	176
polymerase chain	175
thoracic surgery	175
kg min	175
trauma center	175
neurological outcome	175
head injury	175
fluid responsiveness	174
study group	174
endotracheal tube	173
clinical outcome	172
enteral nutrition	171
pandemic influenza	171
health organization	171
symptom onset	170
controlled trials	170
urinary tract	170
acute care	169
protective equipment	169
study population	169
bronchoalveolar lavage	169
patients required	168
coronary artery	168
ethics committee	168
injury severity	168
emergency medicine	168
fluid balance	167
fio ratio	166
nosocomial infection	165
blood loss	165
diabetes mellitus	165
patients included	164
requiring icu	163
medical icu	162
shock patients	162
risk patients	162
severity score	162
severe tbi	161
tbi patients	160
hand hygiene	160
bone marrow	160
immune response	160
blood transfusion	159
neuromuscular blockade	159
results suggest	159
cardiogenic shock	159
machine learning	159
cognitive impairment	158
personal protective	158
care workers	157
transplant recipients	157
measured using	156
may lead	156
gas exchange	156
survival rate	155
seven patients	155
prognostic factors	155
atrial fibrillation	154
hospital cardiac	154
exact test	154
surgical icu	154
signifi cant	154
heart disease	153
randomized clinical	153
blood cell	153
infectious disease	153
poor prognosis	153
patient characteristics	152
left ventricular	152
data analysis	152
virus infection	151
icu los	151
analyzed using	151
lactate levels	151
nervous system	150
six patients	150
tract infections	150
liver transplantation	150
linear regression	150
systemic inflammatory	150
observational studies	150
tract infection	150
serum creatinine	149
adverse effects	149
endotracheal intubation	149
analysis showed	148
continuous variables	148
venous thromboembolism	148
influenza virus	147
abdominal pain	147
life support	147
pulmonary edema	147
teaching hospital	146
streptococcus pneumoniae	145
old male	145
nursing staff	145
assessed using	145
intubated patients	145
noninvasive ventilation	145
high dose	145
pediatric patients	144
injured patients	144
randomized trial	143
sequential organ	143
compared using	143
age group	142
lung disease	142
single center	142
intracranial hemorrhage	142
body mass	141
prospectively collected	141
expiratory pressure	141
multicenter study	141
severe respiratory	140
cardiac injury	140
significantly reduced	140
one year	140
antibiotic resistance	139
blood gases	139
age groups	139
secondary outcomes	139
observational cohort	139
fi rst	139
icu bed	138
acute brain	138
significant reduction	138
obese patients	138
good outcome	137
prone position	137
study included	137
th day	137
healthy volunteers	137
positive patients	136
surgical intervention	136
middle east	136
may help	136
brain tissue	135
practice guidelines	135
respiratory viruses	135
intracranial hypertension	134
study conducted	134
red blood	134
patients showed	133
mortality among	133
acute ischemic	133
peripheral blood	133
health system	132
liver disease	132
medical history	132
significant correlation	132
surgical procedures	132
surgical treatment	131
mental status	131
pediatric intensive	131
posted june	131
new york	131
mass index	131
icu nurses	130
three groups	129
one case	129
serum levels	129
signifi cantly	129
fluid resuscitation	128
eight patients	128
categorical variables	128
necrosis factor	128
bacterial infection	128
square test	127
may result	127
whole blood	127
severe cap	127
patients developed	127
authors declare	127
important role	126
postoperative period	126
systolic blood	126
mean duration	126
parenteral nutrition	126
previously reported	125
general population	125
disease control	125
time points	125
east respiratory	125
myocardial injury	125
head ct	124
significant decrease	124
respiratory infection	124
continuous infusion	124
multivariate logistic	124
surviving sepsis	124
oxygen delivery	124
stroke volume	124
retrospective observational	123
soft tissue	123
urine output	123
severe cases	122
cmv reactivation	122
one hundred	122
physical examination	122
retrospective review	122
data collected	122
widely used	122
patient safety	122
large number	122
quality improvement	122
patients aged	121
aneurysmal subarachnoid	121
confirmed cases	121
emergency room	121
liver failure	121
lymphocyte count	121
medical staff	121
airway management	121
care services	121
clinical findings	121
receiver operating	120
lg ml	120
respiratory infections	120
cardiovascular disease	120
scoring system	120
endothelial cells	119
may improve	119
treated patients	119
corticosteroid therapy	119
group ii	119
icu staff	118
severely ill	118
positive end	118
ct scans	117
ill patient	117
central nervous	117
viral infections	117
confirmed covid	117
posted may	117
independent predictor	117
bacterial pneumonia	117
severe traumatic	117
clinically relevant	117
escherichia coli	117
electronic medical	116
sepsis campaign	116
see table	116
chest pain	116
surgery patients	116
convalescent plasma	116
stem cell	116
requiring mechanical	116
even though	116
prognostic value	116
identify patients	115
gold standard	115
medical intensive	115
patients suffering	115
retrospective chart	115
many patients	114
ill covid	114
poor outcomes	114
general hospital	114
prolonged mechanical	114
clinical signs	113
patients presented	113
median duration	113
clinical studies	113
nine patients	113
hemodynamic instability	113
carbon dioxide	113
confidence intervals	113
care system	113
cerebral perfusion	112
old man	112
mental health	112
stroke patients	112
cerebral blood	112
ill adults	112
two different	112
common cause	112
crit care	112
recent studies	112
glasgow outcome	111
primary endpoint	111
pulmonary hypertension	111
cytokine storm	111
older age	111
white blood	111
cardiopulmonary resuscitation	111
cerebral ischemia	111
leading cause	110
table shows	110
tidal volumes	110
early diagnosis	110
mortality risk	110
invasive aspergillosis	110
hemorrhagic shock	110
two cases	110
study aimed	109
body temperature	109
viral load	109
tumor necrosis	109
icu survivors	109
free days	109
operating room	109
kg day	109
high levels	109
bloodstream infections	109
study showed	109
high incidence	109
study design	109
partial pressure	108
emergency surgery	108
flow nasal	108
cardiopulmonary bypass	108
respiratory system	107
emergency departments	107
higher rate	107
care setting	107
viral infection	107
ill children	107
healthcare professionals	107
clinical presentation	107
hemodynamic parameters	106
combination therapy	106
functional status	106
severity scores	106
several studies	106
negative predictive	106
icu capacity	106
antibiotic use	105
intervention group	105
ed patients	105
icu group	105
head trauma	105
cell count	105
venous catheter	105
one week	104
positive blood	104
respiratory disease	104
high level	104
patients will	104
copd patients	104
united kingdom	104
pulmonary vascular	104
admitted patients	104
nasal cannula	104
care med	103
modified rankin	103
descriptive study	103
clinical isolates	103
chronic health	103
mean time	103
acute pancreatitis	102
fl uid	102
older adults	102
medical care	102
supplementary material	102
missing data	101
abdominal surgery	101
last years	101
chronic kidney	101
may contribute	101
first day	101
vascular resistance	101
center study	101
blood cells	100
severe head	100
ii scores	100
inflammatory cytokines	100
days post	100
small bowel	100
preliminary results	100
hospital beds	100
one study	100
sofa scores	99
sah patients	99
adult icu	99
normal range	99
without permission	99
retrospectively reviewed	99
reuse allowed	98
per year	98
level i	98
roc curve	98
older patients	98
blood products	98
review board	98
viral pneumonia	98
future studies	98
enrolled patients	98
allowed without	98
ten patients	98
positive airway	98
study protocol	97
immunocompromised patients	97
unit patients	97
gene expression	97
elective surgery	97
right ventricular	97
significantly decreased	97
calculated using	97
real time	97
medical record	97
institutional review	97
support ventilation	97
enteral feeding	97
higher incidence	97
additional file	97
systemic inflammation	96
acinetobacter baumannii	96
venous blood	96
time period	96
postoperative complications	96
previously described	95
pregnant women	95
general icu	95
icu team	95
negative bacteria	95
severe influenza	95
task force	95
liver injury	95
outcome data	95
patient outcome	95
severe pneumonia	95
tracheal intubation	94
term outcomes	94
metabolic acidosis	94
icu setting	94
resistant staphylococcus	94
infectious complications	94
severe community	94
negative pressure	94
outcome scale	94
lower mortality	94
chest radiograph	94
fatality rate	94
less likely	93
descriptive statistics	93
physiology score	93
independent predictors	93
multivariable logistic	92
time spent	92
hypoxemic respiratory	92
determined using	92
cerebrospinal fluid	92
simplified acute	92
surgical intensive	92
patient data	92
organ donation	92
time pcr	92
health evaluation	92
hiv infection	92
nosocomial pneumonia	92
identified patients	92
spinal cord	92
general anesthesia	91
clinically significant	91
control measures	91
general surgery	91
nutritional support	91
outcome measures	91
immune system	91
including patients	91
surge capacity	91
three different	91
operating characteristic	91
arrest patients	91
results indicate	91
significant improvement	90
increased significantly	90
required mechanical	90
antimicrobial resistance	90
current study	90
test results	90
cerebral artery	90
remains unclear	90
cause mortality	90
clinical management	90
healthy controls	90
regression models	90
medical conditions	90
study including	89
success rate	89
antimicrobial agents	89
thoracic society	89
findings suggest	89
included studies	89
major cause	89
cfu ml	89
coronavirus pneumonia	89
oxygen consumption	89
saudi arabia	89
flow oxygen	88
underlying disease	88
bacterial infections	88
high prevalence	88
illness severity	88
three days	87
data regarding	87
case reports	87
animal models	87
every hours	87
available data	87
lung transplantation	87
study shows	87
inflammatory mediators	87
infection rate	87
major trauma	87
continuous renal	87
ejection fraction	87
statistical analyses	86
significant association	86
venous pressure	86
old female	86
influenza infection	86
community acquired	86
respiratory syncytial	86
european society	86
working group	86
clinical decision	86
acute myocardial	86
demographic characteristics	85
chest ct	85
randomized trials	85
prospective studies	85
control study	85
gram negative	85
ed visits	85
predictive factors	85
syncytial virus	85
patients diagnosed	85
excluded patients	85
low dose	85
tertiary hospital	85
limited settings	85
selected patients	85
hypertonic saline	85
first week	85
ich patients	85
response syndrome	85
pleural effusion	84
resistant strains	84
emergency care	84
randomly assigned	84
randomised controlled	84
life care	84
published maps	84
medical treatment	84
vein thrombosis	84
also found	84
institutional affiliations	84
chest tube	84
old woman	84
nature remains	83
springer nature	83
care society	83
may occur	83
hospital los	83
healthy subjects	83
severe trauma	83
blood volume	83
aged years	83
remains neutral	83
inspired oxygen	83
positive pressure	83
prospective randomized	83
pain management	83
disseminated intravascular	83
hours post	83
correlation coefficient	83
high rate	83
jurisdictional claims	83
first time	83
new zealand	83
higher levels	82
pulmonary aspergillosis	82
functional outcomes	82
conservative treatment	82
small sample	82
adverse outcomes	82
healthcare system	82
positive predictive	82
analysis revealed	82
considered significant	82
artery bypass	82
receiving mechanical	82
median length	81
reproduction number	81
patients discharged	81
scoring systems	81
data set	81
required icu	81
term outcome	81
twice daily	81
study aims	81
showed significant	81
lung tissue	81
days later	81
may reduce	81
high flow	81
pulmonary complications	81
results show	80
susceptibility testing	80
laboratory findings	80
host response	80
respiratory symptoms	80
patients using	80
worse outcomes	80
acute stroke	80
care doi	80
well tolerated	80
induced lung	79
least days	79
differ significantly	79
unfavorable outcome	79
multiple trauma	79
spontaneous circulation	79
trauma care	79
evaluated using	79
oxidative stress	79
response rate	79
considered statistically	79
sepsis patients	79
congestive heart	79
pressure ventilation	79
diseases society	79
major surgery	79
medical resources	79
mean apache	79
ventilator settings	79
mean difference	79
solid organ	79
higher rates	78
literature review	78
blunt trauma	78
two studies	78
blood lactate	78
tissue oxygen	78
bloodstream infection	78
liver function	78
low risk	78
days following	78
intravascular coagulation	78
beneficial effect	78
posted september	78
may increase	78
refractory status	78
cardiac function	78
organ support	78
diff erence	78
nursing care	78
respiratory mechanics	78
academic medical	77
trend towards	77
outcome measure	77
creatinine clearance	77
continuous positive	77
corticosteroid treatment	77
renal dysfunction	77
glucose levels	77
bacterial co	77
cell transplantation	77
early phase	77
medical patients	77
may provide	77
recent years	77
group compared	77
flow rate	76
infection rates	76
propensity score	76
discharged home	76
abdominal trauma	76
protective ventilation	76
chest wall	76
risk stratification	76
tissue oxygenation	76
international guidelines	76
randomized study	76
lactate dehydrogenase	76
patient died	76
icu days	76
frequently used	76
delayed cerebral	76
time course	75
perfusion pressure	75
driving pressure	75
average time	75
jugular vein	75
plasma concentrations	75
clinical variables	75
cmv infection	75
mcg ml	75
high morbidity	75
may cause	75
middle cerebral	75
pulmonary infection	75
may require	75
comatose patients	75
strongly associated	75
energy expenditure	75
icu population	75
eligible patients	75
assessment method	75
whitney test	75
care physicians	74
first case	74
lung cancer	74
postoperative day	74
resource utilization	74
early identification	74
outcomes among	74
clinical significance	74
much higher	74
patients enrolled	74
inflammatory markers	74
competing interests	74
mean values	74
oral care	74
sex ratio	74
well known	73
skeletal muscle	73
neutropenic patients	73
groups according	73
herd immunity	73
investigate whether	73
medical students	73
extubation failure	73
health services	73
hong kong	73
icu patient	73
normal saline	73
transcranial doppler	73
improve outcomes	73
prothrombin time	73
care team	73
magnetic resonance	73
klebsiella pneumoniae	73
may play	73
acute appendicitis	72
icu day	72
assess whether	72
survival rates	72
external ventricular	72
circulatory failure	72
lung ultrasound	72
six months	72
bed capacity	72
significant changes	72
north america	72
supportive care	72
patients whose	72
severe illness	72
rank test	72
influenza pneumonia	72
protective effect	71
ich score	71
hazard ratio	71
individual patient	71
also associated	71
med doi	71
renal disease	71
surgical procedure	71
small number	71
temperature management	71
patients compared	71
died within	71
emergency medical	71
group received	71
subgroup analysis	71
hospital death	71
recent study	71
one hour	71
pulmonary arterial	71
fluid administration	70
primary care	70
muscle weakness	70
clinical deterioration	70
relative risk	70
diagnostic criteria	70
lung volume	70
carotid artery	70
improve patient	70
analysed using	70
internal medicine	70
time point	70
influenza pandemic	70
improved survival	70
year mortality	70
rankin scale	70
candida auris	70
treatment group	70
clinical research	70
studied patients	70
routine use	70
vena cava	70
three times	70
clinical examination	70
neurologic outcome	70
type ii	69
plasma exchange	69
antimicrobial treatment	69
deep vein	69
gram stain	69
low tidal	69
hemodynamic monitoring	69
patient demographics	69
fluid challenge	69
american thoracic	69
beneficial effects	69
flow cytometry	69
short term	69
early stage	69
studies suggest	69
two weeks	69
organ transplant	69
guidelines recommend	68
compartment syndrome	68
laboratory tests	68
arterial oxygen	68
burn patients	68
care hospital	68
severe infections	68
critical patients	68
previous reports	68
term mortality	68
neuromuscular blocking	68
coma score	68
multivariable analysis	68
patient age	68
every patient	68
stress disorder	68
optimal control	68
artery disease	68
acute illness	68
negative bacilli	68
mcg kg	68
least two	68
mean length	68
altered mental	67
incidence rate	67
hoc analysis	67
final manuscript	67
systematic reviews	67
two days	67
burst suppression	67
average length	67
treatment options	67
cognitive dysfunction	67
supine position	67
emergency physicians	67
early mobilization	67
high frequency	67
pneumococcal pneumonia	67
significantly correlated	67
traumatic stress	67
care providers	67
requiring intensive	67
significant risk	67
cytokine release	66
resistant bacteria	66
culture results	66
prolonged icu	66
early detection	66
four score	66
seven days	66
icu treatment	66
different types	66
investigation results	66
wilcoxon rank	66
positive correlation	66
one month	66
postoperative pain	66
severe brain	66
fluid therapy	66
clinical status	66
previous study	66
strains isolated	66
case history	66
crp levels	66
pulmonary infiltrates	66
multidisciplinary team	66
minimally invasive	66
candida spp	66
adverse event	65
high rates	65
ventilator days	65
laboratory data	65
trauma registry	65
care nurses	65
hemodynamically stable	65
study suggests	65
chronic respiratory	65
one third	65
differential diagnosis	65
longer duration	65
clinical manifestations	65
incubation period	65
antimicrobial susceptibility	65
several limitations	65
primary objective	65
venous thrombosis	65
posted april	65
clinical information	65
wide range	65
upper respiratory	65
icu transfer	65
written informed	65
midline shift	64
lactate level	64
preliminary data	64
coronavirus infection	64
diff erent	64
worse outcome	64
central line	64
platelet counts	64
first step	64
early warning	64
confusion assessment	64
pulse pressure	64
decreased significantly	64
mg ml	64
respiratory virus	64
infection prevention	64
severe patients	64
kidney function	64
phase ii	64
controlled study	64
past medical	64
eff ect	64
discharged alive	64
first group	64
failure requiring	64
pct levels	64
analysis using	64
disk diffusion	64
thromboembolic events	64
related complications	63
clinical study	63
broad spectrum	63
diagnostic tests	63
rib fractures	63
plateau pressure	63
right heart	63
underlying diseases	63
acquired infections	63
patient received	63
note springer	63
directed therapy	63
clinical suspicion	63
clostridium difficile	63
surface area	63
clinical improvement	63
increased morbidity	63
artery catheter	63
i trauma	63
liver transplant	63
limited data	63
significantly improved	63
first study	63
disease progression	63
complication rate	63
cov infection	63
older persons	63
overall survival	63
invasive procedures	62
tissue injury	62
communityacquired pneumonia	62
defined according	62
university hospitals	62
adhesion molecules	62
days vs	62
standard care	62
two years	62
remaining patients	62
longer icu	62
within minutes	62
white matter	62
patient management	62
patients met	62
control subjects	62
icp monitoring	62
berlin definition	62
endothelial cell	62
lower risk	62
venous catheters	62
organ failures	62
trauma centers	62
antibiotic susceptibility	62
associated infections	62
high doses	62
significant relationships	62
sectional study	62
information regarding	62
massive transfusion	62
sensitivity analysis	62
acute coronary	62
male patients	62
predict mortality	62
control groups	61
death rate	61
icu physicians	61
study clinical	61
patients years	61
esophageal pressure	61
plasminogen activator	61
commercially available	61
among icu	61
respiratory samples	61
deep sedation	61
ventilator associated	61
antiviral therapy	61
surgical site	61
common complication	61
breathing trial	61
significant morbidity	61
aspiration pneumonia	61
patients survived	61
odds ratios	61
patient days	61
may represent	61
another study	61
acute cardiac	61
care management	61
candida species	60
drug resistant	60
type i	60
among critically	60
multiorgan failure	60
lung function	60
lung transplant	60
vasopressor support	60
multiplex pcr	60
laboratory parameters	60
burn injury	60
relatively low	60
reperfusion injury	60
secondary outcome	60
glycemic control	60
bacterial meningitis	60
identifi ed	60
fungal infections	60
studies reported	60
organ injury	60
dimer levels	60
loading dose	60
pulmonary function	60
animal model	60
lower extremity	60
secondary analysis	60
internal jugular	60
will need	60
university medical	60
infections caused	59
automated pupillometry	59
patient underwent	59
training program	59
also recorded	59
pulse oximetry	59
cerebral vasospasm	59
patient populations	59
proportional hazards	59
diffuse alveolar	59
will require	59
serum lactate	59
china clinical	59
cumulative incidence	59
risk assessment	59
open reduction	59
data acquisition	59
epithelial cells	59
thrombin generation	59
post hoc	59
gas analysis	59
american college	59
infected pneumonia	59
internal fixation	59
real data	59
cohort studies	59
three cases	59
care settings	59
spectrum antibiotics	58
major bleeding	58
neural networks	58
patients within	58
attending physician	58
healthcare providers	58
national institute	58
care facilities	58
cox proportional	58
phase i	58
acquired weakness	58
clinical condition	58
electronic health	58
chronic renal	58
patient groups	58
hematopoietic stem	58
may benefit	58
care bundle	58
fatal outcome	58
oxygen supply	57
mixed venous	57
case fatality	57
income countries	57
second group	57
early recognition	57
lombardy region	57
serum sodium	57
patient satisfaction	57
antiretroviral therapy	57
plasma concentration	57
reduce mortality	57
drotrecogin alfa	57
day survival	57
endothelial dysfunction	57
gcs score	57
glucose control	57
tissue perfusion	57
severely injured	57
predictive models	56
younger patients	56
steady state	56
observation period	56
aneurysmal sah	56
fluid overload	56
making process	56
took place	56
adult intensive	56
molecular weight	56
early postoperative	56
one patients	56
venous oxygen	56
factors related	56
data indicate	56
ml based	56
proinflammatory cytokines	56
intraventricular hemorrhage	56
brain damage	56
better outcome	56
hospitalised patients	56
hospitalized covid	56
staff members	56
predict fluid	56
lung ventilation	56
growth factor	56
sum test	56
fluid management	56
charlson comorbidity	56
national health	56
antiviral treatment	56
hours later	56
health systems	55
attending physicians	55
chi square	55
chest radiography	55
study performed	55
drug administration	55
comorbidity index	55
neurological complications	55
within one	55
study groups	55
single centre	55
heart surgery	55
nasopharyngeal swab	55
data obtained	55
nan doi	55
failure due	55
significantly greater	55
diagnostic accuracy	55
medical resource	55
neurological outcomes	55
resistant pathogens	55
palliative approach	55
suspected infection	55
male sex	55
organ dysfunctions	55
classified according	55
empirical antibiotic	55
treatment failure	55
clinical diagnosis	55
lpv cds	55
ich volume	54
also observed	54
diabetic patients	54
neural network	54
lung resection	54
frozen plasma	54
apache iii	54
placebo group	54
potential risk	54
hematoma expansion	54
activated protein	54
animal studies	54
may reflect	54
care center	54
four groups	54
study using	54
several factors	54
clinical symptoms	54
respiratory muscle	54
pain scores	54
resonance imaging	54
also significantly	54
influenza patients	54
urinary antigen	54
positive results	54
closely related	54
statistical difference	54
unfractionated heparin	54
international congresses	54
beds per	54
better understand	54
non invasive	54
clinical parameters	54
patients reported	53
future research	53
hospital stays	53
selection bias	53
related mortality	53
patients developing	53
fl ow	53
regression analyses	53
defi ned	53
serum concentrations	53
jugular bulb	53
asah patients	53
acute liver	53
ct findings	53
adult respiratory	53
well established	53
covid patients	53
risk group	53
results showed	53
financial support	53
tissue damage	53
tube placement	53
require icu	53
care professionals	53
systolic function	53
per minute	53
mechanical ventilator	53
inotropic support	53
troponin i	53
niv failure	53
opportunistic infections	53
three months	53
clinical setting	53
cardiovascular diseases	52
single dose	52
effective treatment	52
chronic lung	52
data will	52
least hours	52
developing countries	52
invasive pulmonary	52
remained unchanged	52
hepatic failure	52
wistar rats	52
minute ventilation	52
neuro icu	52
consensus statement	52
normal values	52
clinical criteria	52
previously healthy	52
mg day	52
predicted mortality	52
respiratory secretions	52
data show	52
elevated icp	52
health status	52
adult inpatients	52
significantly longer	52
weight heparin	52
care resources	52
diagnostic testing	52
therapeutic anticoagulation	52
among hospitalized	52
care syndrome	52
cds tool	52
hospital acquired	52
results obtained	52
gastrointestinal tract	52
patients often	52
decision support	51
mean value	51
using standard	51
tracheostomy tube	51
second wave	51
chronic liver	51
patient group	51
every day	51
risk score	51
blocking agents	51
tested positive	51
cardiac failure	51
inspiratory pressure	51
fisher exact	51
high number	51
acute pulmonary	51
daily living	51
tertiary referral	51
ventilator support	51
cytokine production	51
distancing measures	51
better outcomes	51
bed icu	51
care beds	51
low levels	51
american society	51
herpes simplex	51
foreign body	51
pressure monitoring	51
control patients	51
may explain	51
unit admission	51
respiratory diseases	51
vasoactive drugs	51
inferior vena	51
outcomes included	51
published data	51
severe hypoxemia	51
type diabetes	51
may develop	51
consecutive adult	51
cervical spine	51
hospital survival	50
first three	50
liver cirrhosis	50
pk pd	50
daily basis	50
gestational age	50
injury patients	50
abdominal wall	50
previously published	50
blood transfusions	50
ill adult	50
monoclonal antibodies	50
ventricular fibrillation	50
patients experienced	50
level trauma	50
infl ammatory	50
thrombotic complications	50
prospectively studied	50
currently available	50
target temperature	50
prospective multicenter	50
insulin therapy	50
receive either	50
mortality due	50
fresh frozen	50
icu delirium	50
median icu	50
paediatric intensive	50
kg hr	50
general ward	50
remains controversial	50
two hours	50
chest radiographs	50
increased incidence	50
therapeutic intervention	50
sepsis syndrome	50
multicenter cohort	50
clavulanic acid	50
patients require	50
confounding factors	50
care hospitals	50
term survival	50
secondary endpoints	49
virus disease	49
first dose	49
cardiac surgical	49
statistically different	49
cardiac arrests	49
icu death	49
vte prophylaxis	49
newly developed	49
converting enzyme	49
cox regression	49
disease patients	49
patients suffered	49
posttraumatic stress	49
standard deviations	49
county level	49
lopinavir ritonavir	49
alveolar damage	49
similar results	49
following criteria	49
mdr pathogens	49
infl uenza	49
mechanical ventilators	49
identified using	49
acute exacerbation	49
care nursing	49
group showed	49
healthcare systems	49
new onset	49
using data	49
better understanding	49
body surface	49
birth weight	49
bypass grafting	49
ct head	49
icu support	49
continuous eeg	49
clinical care	49
red cell	49
antifungal therapy	49
rescue therapy	49
receptor antagonist	49
conducted using	49
eff ects	49
acute hypoxemic	49
hemodynamic stability	49
clinical progression	48
hospital care	48
negative staphylococci	48
feeding tube	48
cell death	48
worse prognosis	48
resource use	48
severe forms	48
empiric therapy	48
muscle mass	48
serum samples	48
immune cells	48
quality control	48
term care	48
false positive	48
cerebral infarction	48
comorbid conditions	48
potential role	48
organ function	48
severe infection	48
recent data	48
lung compliance	48
cd cd	48
admission rate	48
patient developed	48
decompressive craniectomy	48
following parameters	48
center retrospective	48
average number	48
arterial lactate	48
successful weaning	48
higher level	48
tissue hypoxia	48
ml cmh	48
times higher	48
antiviral drugs	48
congenital heart	48
significantly elevated	48
data available	48
per hour	48
patients due	48
ex vivo	48
undergoing cardiac	48
done using	48
organ system	48
authors concluded	48
march th	48
damage control	48
multivariate regression	48
performance status	48
prospectively enrolled	48
rater reliability	48
secondary bacterial	48
also reported	48
month mortality	48
gastrointestinal bleeding	47
epidemiological characteristics	47
may influence	47
will also	47
cerebrovascular disease	47
vast majority	47
antibiotic prophylaxis	47
vap rates	47
reduced mortality	47
clinical experience	47
clinical severity	47
serious complications	47
preventive measures	47
human metapneumovirus	47
twelve patients	47
ecmo support	47
optic nerve	47
inspiratory flow	47
using spss	47
coagulation parameters	47
york city	47
investigated whether	47
hospital setting	47
ventricular drain	47
urinary catheter	47
improved outcomes	47
therapeutic interventions	47
adverse drug	47
evaluate whether	47
gel electrophoresis	47
platelet transfusion	47
survival time	47
bleeding complications	47
ppe use	47
hospital course	47
influenza season	47
icu occupancy	47
many countries	47
arterial hypertension	47
variables associated	47
bal fluid	47
readily available	47
evidence suggests	47
supplemental oxygen	46
base excess	46
cognitive interventions	46
invasive fungal	46
renal impairment	46
practice guideline	46
median value	46
corresponding author	46
team members	46
poor neurological	46
european countries	46
total body	46
respiratory therapists	46
high sensitivity	46
significant impact	46
often used	46
negative patients	46
rank sum	46
stenotrophomonas maltophilia	46
hospital ward	46
respiratory function	46
recently published	46
controlled ventilation	46
predicted body	46
elevated levels	46
identify factors	46
days mortality	46
serious adverse	46
usual care	46
patients needed	46
icu data	46
increased levels	46
external fixation	46
neurological recovery	46
using chi	46
pilot rct	46
dysfunction syndrome	46
apache score	46
severe coronavirus	46
lung water	46
anticancer therapy	46
infrared spectroscopy	46
partial thromboplastin	46
candida albicans	46
standard therapy	46
using two	46
clinical conditions	46
medical school	45
increasing number	45
following cardiac	45
radial head	45
femoral artery	45
ideal body	45
per group	45
without significant	45
propofol infusion	45
retrospectively analyzed	45
cardiac troponin	45
month follow	45
high quality	45
wound infection	45
icu management	45
group versus	45
common pathogens	45
severity index	45
clinical use	45
subgroup analyses	45
care department	45
smooth muscle	45
visual inspection	45
deceased patients	45
literature search	45
chest compressions	45
host defense	45
female patients	45
posted october	45
two independent	45
diff erences	45
study patients	45
admission diagnosis	45
care capacity	45
air pollution	45
data showed	45
respiratory insufficiency	45
median days	45
positive cultures	45
neuromuscular blockers	45
resistant isolates	45
prognostic factor	45
complication rates	45
often associated	45
subdural hematoma	45
continuous data	45
wound healing	45
hospital admissions	45
fungal infection	45
improve survival	45
retrospective case	45
human immunodeficiency	45
volume expansion	44
identifying patients	44
lavage fluid	44
negative correlation	44
failure rate	44
hemorrhagic stroke	44
trauma surgery	44
thoracic trauma	44
health professionals	44
pcr assay	44
early treatment	44
general intensive	44
initial treatment	44
immune function	44
influenza vaccination	44
randomly selected	44
new cases	44
major role	44
clinical impact	44
monoclonal antibody	44
predictive model	44
resistance genes	44
brain dysfunction	44
good neurological	44
also collected	44
trend toward	44
icu resources	44
core temperature	44
continuous monitoring	44
children admitted	44
treatment groups	44
young children	44
neurological examination	44
life expectancy	44
research ethics	44
diffusion method	44
acutely ill	44
repeated measures	44
cost per	44
cardiac dysfunction	44
higher proportion	44
iu ml	44
study demonstrated	44
year study	44
natriuretic peptide	44
different levels	44
immune responses	44
related infections	44
ed visit	44
resource allocation	44
study will	44
sepsis septic	43
standard treatment	43
will help	43
organ damage	43
abcdef bundle	43
months post	43
medical university	43
post operative	43
past years	43
amino acid	43
general wards	43
treatment strategies	43
artificial intelligence	43
rbc transfusion	43
many studies	43
met inclusion	43
potential confounders	43
cuff pressure	43
roc curves	43
individual patients	43
significantly shorter	43
antibiotic administration	43
main results	43
health record	43
influenza viruses	43
saps score	43
limited number	43
rapid response	43
surgical management	43
south africa	43
adjunctive therapy	43
medical centers	43
lumbar puncture	43
study date	43
group iii	43
laboratory values	43
seasonal influenza	43
large cohort	43
information system	43
mechanical power	43
useful tool	43
routinely used	43
following icu	43
survival analysis	43
final version	43
adult icus	43
weight loss	43
study found	43
function tests	43
inhaled nitric	43
inflammatory responses	43
fatty acids	43
main cause	43
pupillary light	43
factors may	43
convenience sample	43
ethical committee	43
younger age	43
altman analysis	43
available resources	43
brain edema	43
inhospital mortality	43
oxygen extraction	43
patients according	43
neurointensive care	43
clinical factors	43
drug interactions	43
life threatening	43
serum albumin	43
current practice	43
cytokine levels	43
transpulmonary thermodilution	43
april th	43
pneumonia caused	43
cerebral performance	43
difficult airway	42
may affect	42
undergoing elective	42
ebola virus	42
average duration	42
ali ards	42
respiratory illness	42
log cfu	42
mortality associated	42
lung biopsy	42
significant predictors	42
rat model	42
authors read	42
mainly due	42
thromboplastin time	42
poor functional	42
hours following	42
ethics approval	42
favorable outcome	42
spontaneous ich	42
south korea	42
clinical response	42
pleural fluid	42
hospital icu	42
patients following	42
discharge disposition	42
end point	42
results demonstrate	42
specific treatment	42
day post	42
mononuclear cells	42
strong recommendation	42
higher apache	42
vascular permeability	42
independent variables	42
interval ci	42
significant higher	42
attributable mortality	42
mortality compared	42
treated group	42
screening tool	42
immunodeficiency virus	42
flow velocity	42
brain trauma	42
significant change	42
kidney failure	42
positive culture	42
risk groups	42
less frequently	42
patient ratio	42
study demonstrates	42
consensus conference	42
group vs	42
hematoma volume	42
dose thromboprophylaxis	42
vascular injury	42
neuraminidase inhibitors	42
clinical evaluation	42
systemic vascular	42
clinical settings	41
mic values	41
group patients	41
way anova	41
time series	41
resistant organisms	41
postoperative course	41
good clinical	41
spectrum beta	41
days prior	41
blood oxygen	41
cant diff	41
secondary infections	41
related organ	41
antimicrobial stewardship	41
initial management	41
grade iii	41
five days	41
patients older	41
diagnostic yield	41
clinical samples	41
two methods	41
prior studies	41
plasma samples	41
cases per	41
social media	41
categorical data	41
patients per	41
first year	41
year survival	41
bacterial growth	41
transthoracic echocardiography	41
less severe	41
blood components	41
factors influencing	41
comparative study	41
may need	41
higher prevalence	41
children aged	41
mathematical model	41
complications associated	41
another hospital	41
studies showed	41
sirs criteria	41
remains unknown	41
mass casualty	41
hospital wards	41
ward patients	41
significantly less	41
unstable patients	41
esrd patients	41
healthy control	41
cognitive function	41
total patients	41
intensive insulin	41
baseline values	41
severe outcomes	41
expert opinion	40
primary outcomes	40
hospital day	40
low molecular	40
recombinant human	40
treatment duration	40
surgical tracheostomy	40
nutritional status	40
patients ventilated	40
electrical activity	40
treat patients	40
ventilation time	40
data suggests	40
within months	40
spontaneously breathing	40
oxygen desaturation	40
obtained using	40
icp mmhg	40
gut microbiota	40
common causes	40
significant proportion	40
therapeutic management	40
received tocilizumab	40
dawley rats	40
kcal kg	40
renal insufficiency	40
may present	40
volume ventilation	40
important factor	40
mean icu	40
mg twice	40
main outcome	40
bypass surgery	40
penetrating trauma	40
lung diseases	40
mean number	40
induced thrombocytopenia	40
medical management	40
blood product	40
experimental study	40
splenic injury	40
relatively high	40
multicenter prospective	40
extravascular lung	40
good functional	40
first line	40
intramedullary nailing	40
will likely	40
hematologic malignancies	40
insulin infusion	40
pneumonia severity	40
septic complications	40
less common	40
also showed	40
physical therapy	40
ug ml	40
different groups	40
existing kidney	40
hours prior	40
low flow	40
appropriate treatment	40
icu hospitalization	40
positive cocci	39
immunocompetent patients	39
study reported	39
oxygen tension	39
tracheal aspirates	39
sodium chloride	39
one day	39
high degree	39
common among	39
internal carotid	39
potential benefits	39
longer time	39
significance level	39
major abdominal	39
important cause	39
sensitivity analyses	39
epidemiological data	39
positive test	39
global health	39
shockable rhythm	39
coronary angiography	39
study cohort	39
antibiotic prescription	39
male gender	39
virus infections	39
abdominal sepsis	39
avian influenza	39
severe complications	39
qualitative data	39
postoperative care	39
ml vs	39
per cent	39
cell surface	39
lower incidence	39
resistant gram	39
fi ndings	39
per se	39
overall incidence	39
pulmonary oedema	39
empirical treatment	39
ventilatorassociated pneumonia	39
four different	39
studies included	39
per week	39
bacterial translocation	39
increasing age	39
urine samples	39
nucleic acid	39
neurosurgical patients	39
burned patients	39
clinical assessment	39
blood stream	39
hemodynamically unstable	39
blood count	39
cirrhotic patients	39
northern italy	39
ill icu	39
studies using	39
postoperative delirium	39
femoral neck	39
pediatric icu	39
early mortality	39
first patient	39
cardiopulmonary arrest	39
likely due	39
fold increase	39
patient presented	39
simplex virus	39
left ventricle	39
good correlation	39
muscle strength	39
therapy may	39
one hand	39
likert scale	39
included age	39
hepatic encephalopathy	39
upper limit	39
also performed	39
amino acids	39
multicentre study	39
highly significant	39
stable patients	38
cytomegalovirus infection	38
upper airway	38
patient selection	38
coronary syndrome	38
nitrogen balance	38
medical surgical	38
patient admitted	38
pneumonia patients	38
bacterial pathogens	38
emergency response	38
transmission dynamics	38
intellectual content	38
demographic information	38
identify risk	38
empiric antibiotic	38
onset vap	38
final diagnosis	38
advanced age	38
targeted temperature	38
complications related	38
among survivors	38
related quality	38
months later	38
initial dose	38
poorly understood	38
consecutive days	38
expiratory flow	38
recently reported	38
vascular access	38
generating procedures	38
idsa ats	38
first report	38
care systems	38
binding protein	38
total parenteral	38
study also	38
release syndrome	38
cell transplant	38
statistical methods	38
developed acute	38
received antibiotics	38
creatine kinase	38
large proportion	38
warning score	38
ace inhibitors	38
linear mixed	38
bacterial sepsis	38
median number	38
chest trauma	38
bacterial resistance	38
reported cases	38
major complications	38
admission gcs	38
developed ards	38
infusion rate	38
four hours	38
low level	38
health problem	38
clinical picture	38
small intestine	38
performance category	38
vitro activity	38
higher doses	38
acinetobacter spp	38
portal vein	38
reactive oxygen	38
dead space	38
icu liberation	38
bacterial coinfection	38
depression scale	38
control practices	38
early stages	38
neurological injury	38
ketamine infusion	38
stage renal	38
time periods	38
cardiac disease	37
icu cases	37
years ago	37
lower extremities	37
high volume	37
fold higher	37
group without	37
differed significantly	37
mortality prediction	37
patients affected	37
open lung	37
associated injuries	37
remained stable	37
french icus	37
extracorporeal life	37
upper extremity	37
glucose level	37
decreased mortality	37
medical therapy	37
secondary infection	37
pharmaceutical interventions	37
iu kg	37
week period	37
complement activation	37
infection may	37
ventilated icu	37
early use	37
million people	37
weaning failure	37
higher percentage	37
much lower	37
case mix	37
received either	37
term follow	37
vegetative state	37
medical team	37
intravenous infusion	37
data extraction	37
light reflex	37
right atrium	37
motor vehicle	37
filtration rate	37
hip fracture	37
alcohol abuse	37
therapeutic options	37
deep venous	37
lymphocyte counts	37
traumatic injury	37
pulse contour	37
bactericidal activity	37
care facility	37
neurological deficits	37
current guidelines	37
underlying medical	37
brain mri	37
several days	37
sedation scale	37
community hospital	37
th percentile	37
controlled clinical	37
right ventricle	37
patients transferred	37
may include	37
ethical approval	37
required invasive	37
mean icp	37
young adults	37
chronic pain	37
lung protective	37
critical ill	37
serum glucose	37
ventricular function	37
may decrease	37
early administration	37
square tests	37
medical services	37
longer hospital	37
dysfunction failure	37
eeg monitoring	36
main causes	36
interim guidance	36
higher among	36
clinical benefit	36
prior antibiotic	36
polymicrobial aetiology	36
preliminary study	36
significantly better	36
family satisfaction	36
pain score	36
respiratory viral	36
higher number	36
time frame	36
interquartile ranges	36
confirmed case	36
health emergency	36
examination revealed	36
also evaluated	36
intermediate care	36
glass opacities	36
adverse outcome	36
medical education	36
increased icu	36
characteristic curve	36
care admission	36
thrombolytic therapy	36
cystic fibrosis	36
health workers	36
venous access	36
based study	36
probably due	36
requiring hospitalization	36
sedated patients	36
respiratory complications	36
undergoing thoracic	36
increasingly used	36
received mechanical	36
transpulmonary pressure	36
multiple logistic	36
ulcer prophylaxis	36
medical research	36
hess grade	36
pearson correlation	36
elective cardiac	36
ventilation duration	36
fracture healing	36
richmond agitation	36
rating scale	36
early tracheostomy	36
improves survival	36
developed severe	36
twenty patients	36
trauma team	36