bigram

This is a table of type bigram and their frequencies. Use it to search & browse the list to learn more about your study carrel.

bigram	frequency
respiratory tract	550
human rhinovirus	499
respiratory viruses	465
signifi cant	361
identifi ed	360
respiratory syncytial	335
signifi cantly	333
syncytial virus	325
acute respiratory	309
viral infections	305
epithelial cells	288
lower respiratory	271
confl ict	252
respiratory infections	242
hrv infection	230
common cold	224
infl ammatory	218
respiratory illness	209
lung function	196
rhinovirus infection	191
asthma exacerbations	190
young children	187
tract infections	182
infl ammation	182
human rhinoviruses	179
viral infection	172
upper respiratory	154
respiratory viral	154
infl uenza	152
fi rst	143
respiratory symptoms	140
defi ned	139
hrv infections	134
human metapneumovirus	130
respiratory virus	127
asthma exacerbation	127
pulmonary disease	125
gene expression	125
respiratory disease	124
heart rate	123
cohort study	121
airway epithelial	118
fl uid	118
chain reaction	113
polymerase chain	113
rhinovirus infections	109
mean age	108
wa hrv	108
vp vp	106
fi brosis	105
chronic obstructive	105
age years	105
induced asthma	104
risk factors	104
obstructive pulmonary	103
viral rna	101
lung cancer	98
tract infection	96
respiratory infection	96
childhood asthma	96
ifn lambda	95
viral respiratory	94
risk factor	94
virus infection	93
cystic fi	90
lung transplant	90
immune response	90
emergency department	89
disease severity	89
air pollution	88
fi ndings	88
peripheral blood	87
reverse transcription	87
vocal cord	84
doc id	82
influenza virus	82
cord uid	82
acute asthma	82
united states	79
rsv infection	79
hrv species	79
cant differences	78
nucleic acid	78
time pcr	78
determine whether	78
increased risk	77
innate immune	75
cell culture	75
transplant recipients	74
hrv serotypes	74
median age	74
hospitalized children	74
human bocavirus	73
virus infections	73
respiratory pathogens	71
interest nil	70
interest none	70
physical activity	70
pulmonary function	69
allergic rhinitis	67
cantly higher	67
among children	67
infl uence	66
present study	65
viral load	65
healthy controls	64
lung disease	64
acquired pneumonia	64
airway inflammation	64
controlled trial	63
acute exacerbations	63
previous studies	63
cord movement	63
measured using	62
airway narrowing	62
confi rmed	62
children aged	62
otitis media	62
pcr assays	61
experimental rhinovirus	61
bone marrow	60
cell lines	60
birth cohort	60
asthmatic subjects	60
immune responses	60
bronchial epithelial	59
immunocompromised patients	59
antiviral activity	58
stable patients	58
respiratory illnesses	58
airway responsiveness	58
pcr assay	57
upper airway	57
intensive care	57
asm layer	56
statistically signifi	56
results patients	56
pulmonary rehabilitation	56
pleural ultrasound	56
systematic review	55
rna viruses	55
adult patients	55
clinical specimens	54
influenza viruses	54
chest pain	54
severe asthma	53
logistic regression	53
severe respiratory	53
bronchoalveolar lavage	53
molecular epidemiology	52
airfl ow	52
performed using	52
ammatory cytokines	52
smooth muscle	52
age groups	52
previously described	52
cystic fibrosis	52
two groups	51
hrv ent	51
respiratory failure	51
multiplex pcr	51
asm cell	50
attenuated wa	50
cigarette smoke	50
rna polymerase	50
fev fvc	50
ow obstruction	50
spent outdoors	50
clinical features	50
cell responses	50
nomination nil	49
atopic dermatitis	49
phylogenetic analysis	49
month period	49
diffi cult	48
rate variability	47
pregnant women	47
randomized controlled	47
protective immunity	47
type iii	47
lower airway	46
viral pathogens	46
rhinovirus colds	46
mrna expression	46
clinical trials	46
frequently detected	46
children hospitalized	46
crp levels	46
induced sputum	45
fl ow	45
copd patients	45
effi cacy	45
human coronavirus	45
least one	45
ow cytometry	44
medical records	44
hong kong	44
body mass	44
acute rejection	44
immune system	44
hospitalized patients	44
hrv strains	44
respiratory diseases	44
admission rates	44
adhesion molecule	44
clinical samples	43
acute wheezing	43
mean difference	43
significantly higher	43
important role	43
positive samples	43
mass index	43
goblet cell	43
parainfluenza virus	43
study period	42
gord symptoms	42
fev predicted	42
cell transplant	42
action plan	42
hrv detection	42
dl co	42
vo peak	42
airway distensibility	42
gas transfer	42
stem cell	42
hela cells	42
cant difference	42
clinical outcomes	42
asthmatic children	42
cell surface	42
dimensionality reduction	42
respiratory syndrome	42
hyperinfl ation	42
parainfluenza viruses	42
hh pathway	42
vte prophylaxis	42
human enterovirus	41
may reduce	41
nitric oxide	41
rhinovirus serotypes	41
severe acute	41
cell cultures	41
rhinovirus species	41
nucleic acids	41
clinical characteristics	40
acute lower	40
airway epithelium	40
early childhood	40
infectious diseases	40
virulent wa	40
index case	39
nasal secretions	39
culture positive	39
new zealand	39
first years	39
asthma prevalence	39
control group	38
airway infl	38
gnotobiotic pigs	38
leading cause	38
allergic diseases	38
time spent	38
clinical practice	38
acute otitis	38
airway smooth	38
phylogenetic tree	38
viral persistence	37
effi ciency	37
asthma symptoms	37
complete genome	37
prospective study	37
first year	37
mouse model	37
years old	37
intercellular adhesion	37
virus detection	37
internal control	36
clinical severity	36
old children	36
odds ratio	36
tract disease	36
fi broblasts	36
natural history	36
early life	36
clinical data	36
pcr products	36
rotavirus infection	36
atopic subjects	36
reverse transcriptase	36
patients admitted	36
infi ltrates	36
food allergy	36
atopic asthma	35
hypertonic saline	35
methods subjects	35
may also	35
nasopharyngeal aspirates	35
methods retrospective	35
foreign body	35
complication rate	35
clinically signifi	35
time rt	35
recent studies	35
viral replication	35
pleural fl	35
support nhmrc	35
fl ocked	35
allergic disease	35
quantifi ed	35
three patients	35
febrile neutropenia	35
common respiratory	35
northern territory	35
adverse event	35
gene transfer	35
days post	35
lung volume	35
energy expenditure	35
host immune	35
emphysema extent	35
fi nal	35
expression profi	35
birth weight	34
viral etiology	34
persistent asthma	34
wheezing episodes	34
tobacco smoke	34
acute bronchiolitis	34
applied biosystems	34
high prevalence	34
hrv rna	34
type i	34
lymphoid tissues	34
detection rate	34
host cell	34
respiratory distress	34
care unit	33
hrv replication	33
rsv infections	33
prospective cohort	33
lower airways	33
large number	33
viruses detected	33
genetic diversity	32
healthy subjects	32
primary care	32
positive cases	32
throat swabs	32
predictive value	32
acute severe	32
controlled trials	32
sectional study	32
diagnosed asthma	32
asthma attacks	32
antiviral agents	32
acute exacerbation	32
preliminary results	31
analysed using	31
chronic cough	31
inhaled corticosteroids	31
human respiratory	31
retrospective review	31
amino acid	31
particulate matter	31
allergen exposure	31
health care	31
also showed	31
viral detection	31
mg ml	31
public health	31
lamina propria	31
human airway	31
hospital admissions	31
active site	31
molecular methods	31
table shows	30
hrv types	30
respiratory samples	30
one subject	30
children born	30
human lung	30
chronic respiratory	30
hospital admission	30
vp sequences	30
receptor expression	30
nutritional status	30
significant difference	30
viral co	30
identifi cation	30
nasal washings	30
strongly associated	30
statistically significant	30
cell proliferation	30
igg asc	30
nucleotide sequence	30
commonly used	30
quantifi cation	29
prototype strains	29
modifi ed	29
pilot study	29
tidal breathing	29
may contribute	29
health study	29
cohort studies	29
time points	29
rna synthesis	29
positive results	29
hrv respiratory	29
common colds	29
febrile hrv	29
coding region	29
parainfl uenza	29
high risk	29
cantly different	29
current asthma	29
small airways	29
acute lung	29
months later	29
symptom scores	29
sore throat	29
significant differences	29
immune defect	29
epithelial cell	29
bp deletion	28
body inhalation	28
olic acid	28
stranded rna	28
pacifi ca	28
cell parameters	28
second test	28
wheezing children	28
lung infl	28
metal screws	28
prince charles	28
ct larynx	28
neutrophilic asthma	28
tissue culture	28
charles hospital	28
appropriate vte	28
acute cough	28
exible bronchoscopy	28
lc sprint	28
without bpd	28
ocked swabs	28
antibiotic use	28
side effects	28
function tests	28
nasal fl	28
time reverse	28
increased airway	28
infection may	28
methods patients	28
may play	28
refl ux	28
born preterm	28
ww use	28
fl exible	28
ammatory mediators	28
haematological malignancy	28
virus isolation	28
fi bre	28
retrospective audit	28
viral culture	28
null mefs	28
ed using	28
pleural effusions	28
minute walk	28
pulmonary infi	28
sprint junior	28
determined using	28
airway dysfunction	28
elastic recoil	28
specific iga	28
initial phase	28
may provide	27
cell transplantation	27
samples collected	27
using real	27
mononuclear cells	27
clinical symptoms	27
host response	27
vp region	27
age group	27
preschool children	27
nucleotide divergence	27
inoculated pigs	27
rhinovirus genotype	27
protein expression	27
pigs inoculated	27
surface receptor	27
based study	26
standard deviation	26
blood mononuclear	26
antibody responses	26
adverse events	26
without asthma	26
carbon monoxide	26
hct recipients	26
recurrent wheezing	26
virus type	26
demographic data	26
nested pcr	26
broad spectrum	26
cold symptoms	26
like illness	26
virus replication	26
control subjects	26
sequence analysis	26
acid sequence	26
older children	26
molecular typing	25
specific ige	25
closely related	25
positive result	25
cold virus	25
detection methods	25
control study	25
asthma control	25
airways disease	25
severe disease	25
common cause	25
untranslated region	25
data collected	25
mean duration	25
human coronaviruses	25
allergic sensitization	25
minor group	25
asthmatic patients	25
dust mite	25
time series	25
hematopoietic cell	25
year old	25
antibiotic therapy	25
disease control	25
severe pneumonia	25
virus detected	25
year period	25
house dust	24
chronic disease	24
barrier function	24
study aimed	24
igg memory	24
induced wheezing	24
risk score	24
studies using	24
geometric mean	24
adverse effects	24
informed consent	24
hrv positive	24
dependent rna	24
risk children	24
tested positive	24
diagnostic procedures	24
highly conserved	24
increasing age	24
major cause	24
nasal washes	24
real time	24
human cell	24
test results	24
may cause	24
infected cells	24
recent study	24
infections among	24
healthy children	24
data collection	24
preterm birth	24
pediatric patients	24
odds ratios	24
rhinovirus type	24
infl uenced	24
results suggest	24
human enteroviruses	24
airway remodeling	24
tertiary hospital	24
western blot	23
new york	23
infected mice	23
limited data	23
airway obstruction	23
rhinovirus rna	23
proinfl ammatory	23
oxidative stress	23
general population	23
success rate	23
rsv bronchiolitis	23
genome sequences	23
respiratory secretions	23
regression analysis	23
one patient	23
bacterial infections	23
ent infections	23
viral loads	23
cantly lower	23
severe copd	23
three age	23
induced neutrophilic	23
airway hyperresponsiveness	23
reverse transcribed	23
clinical isolates	23
strand rna	23
study showed	23
oxygen supplementation	23
previously shown	23
stable asthma	23
retrospective case	23
cytokine release	22
secondary outcomes	22
consecutive patients	22
general medical	22
primary outcome	22
fifty percent	22
three hospitals	22
severe persistent	22
simultaneous detection	22
described previously	22
developing countries	22
mechanical ventilation	22
one study	22
cell migration	22
children recruited	22
oxygen use	22
also found	22
data suggest	22
significantly associated	22
mean fev	22
small number	22
healthy population	22
copd subjects	22
lung volumes	22
baseline airway	22
case reports	22
situ hybridization	22
primer pairs	22
ammatory response	22
eosinophilic asthma	22
profi le	22
based amplification	22
control antigen	22
lung tissue	22
stable copd	22
case series	22
dietary intakes	22
sputum cultures	22
noncoding region	22
patients attending	22
interstitial pneumonia	22
benefi ts	22
invasive ventilation	22
experimentally induced	21
version posted	21
rhinovirus prototype	21
forced oscillation	21
cant increase	21
tj proteins	21
fi lter	21
respiratory physicians	21
extended family	21
risk interventions	21
lpc lv	21
elevated rvsp	21
niv service	21
viral genome	21
experimental hrv	21
transmural pressure	21
retrospective study	21
spontaneous pneumothorax	21
eb vs	21
caudal lobe	21
neutrophilic infl	21
three months	21
factors associated	21
seven patients	21
cell volume	21
lung resection	21
cantly less	21
cpap implementation	21
pulmonary tuberculosis	21
eflow rapid	21
neutrophilic aad	21
multiplex rt	21
bore icc	21
newly identified	21
inhaler technique	21
pathway genes	21
exercise tolerance	21
volume density	21
nebulization time	21
longitudinal health	21
ultrasound marking	21
calcium chelators	21
clinic population	21
colistin use	21
tasmanian longitudinal	21
implementation sleep	21
granted medrxiv	21
whole airway	21
rst exposure	21
mrc grade	21
volume fractions	21
hospitalized infants	21
nasal swabs	21
relieves dyspnoea	21
previous study	21
total adr	21
infectious virus	21
oscillation technique	21
apoptotic cells	21
citrate increased	21
thoracic medicine	21
glucose tolerance	21
bronchoscopy plus	21
results participants	21
national surveillance	21
bronchopulmonary dysplasia	21
causative agents	21
mouse trachea	21
written action	21
aboriginal children	21
step pcr	21
received lpc	21
transplant rejection	21
mw achieved	21
proportion immune	21
ammatory phenotypes	21
neutrophil proteases	21
epidemiological studies	21
new bpd	21
ultrasound training	21
author funder	21
native lung	21
service model	21
overall survival	21
standard exercise	21
increased ar	21
significant increase	21
cant correlation	21
adl score	21
sleep study	21
following stimulation	21
palliative care	21
transplant patients	21
positive upa	21
viruses including	21
normal cxr	21
city hospital	21
months post	21
reduced dlco	21
best guess	21
virus bronchiolitis	21
lower fi	21
increased susceptibility	21
viral pathogen	21
translation effi	21
pulmonary side	21
niv relieves	21
inhaled therapy	21
cycle ergometer	21
daily living	21
image guidance	21
oxygen saturation	21
ep receptors	21
cough rate	21
maternal asthma	21
ventilation distribution	21
cytokine response	21
ep receptor	21
positive specimens	21
capsule endoscope	21
well established	21
ultrafi ne	21
cdna synthesis	21
diffusing capacity	21
asthma foundation	21
phase iii	21
stage nsclc	21
reproductive factors	21
copyright holder	21
volume fraction	21
like cells	21
tc groups	21
key hh	21
aeroneb go	21
pleural infection	21
total lung	21
inflammatory response	21
symptom control	21
common symptom	21
cell pro	21
plus bal	21
treatment options	20
multiple viruses	20
well known	20
different viruses	20
clinical impact	20
clinical manifestations	20
rv infection	20
surveillance data	20
thrombocytosis group	20
term care	20
agarose gel	20
asthma patients	20
new rhinovirus	20
exhaled nitric	20
positive patients	20
acute viral	20
major group	20
machine learning	20
prevalence rates	20
airway disease	20
obstructive lung	20
clinical disease	20
table iii	20
various respiratory	20
protease inhibitors	20
overall prevalence	20
adjusted odds	20
allergic airway	20
bacterial pathogens	20
symptom severity	19
chest tightness	19
associated wheezing	19
numbering system	19
hospital stay	19
chronic lung	19
younger age	19
lung diseases	19
community acquired	19
human parainfluenza	19
mechanisms underlying	19
serum ige	19
rhinovirus illnesses	19
adult mice	19
monoclonal antibody	19
international study	19
necrosis factor	19
recently identified	19
capsid protein	19
nucleotide sequences	19
protein levels	19
positive test	19
epidemiologic studies	19
ige levels	19
febrile respiratory	19
children less	19
highly prevalent	19
ibs method	19
also detected	19
study population	19
similar results	19
nasal samples	19
respiratory function	19
based studies	19
rate dynamics	19
prospective studies	19
two years	19
molecular assays	19
defi ne	19
sputum samples	18
chronic asthma	18
children admitted	18
computed tomography	18
may occur	18
using standard	18
tumor necrosis	18
sample size	18
respiratory health	18
elispot assay	18
clinical trial	18
hematopoietic stem	18
outdoor air	18
new hrv	18
virus shedding	18
study involving	18
oral corticosteroids	18
asthma attack	18
cell counts	18
united kingdom	18
viral capsid	18
primary prevention	18
iga asc	18
marrow transplant	18
older people	18
clinical course	18
age children	18
pcr primers	18
like receptor	18
iii ifn	18
results show	18
wheezing illness	18
novel hrv	18
refl ect	18
assessed using	18
clinically relevant	18
study suggests	18
smoking status	18
previously reported	18
among infants	18
birth outcomes	18
hrv isolates	18
health survey	18
recent years	18
respiratory exacerbations	18
bronchial hyperresponsiveness	18
improved detection	18
infected patients	18
randomness index	18
natural products	18
made available	18
significantly different	18
study shows	18
new method	18
reduced airway	18
nasal epithelial	17
previously unrecognized	17
adverse birth	17
using polymerase	17
viruses associated	17
single virus	17
detection rates	17
rhinovirus serotype	17
analyzed using	17
new treatment	17
different hrv	17
host cells	17
molecular detection	17
forced expiratory	17
inflammatory cells	17
hrv group	17
airway cells	17
patient age	17
respiratory specimens	17
three different	17
pain patients	17
detected viruses	17
forward primer	17
exact test	17
medication use	17
hrv type	17
genomic rna	17
disease pathogenesis	17
middle ear	17
rotavirus vaccines	17
tract symptoms	17
hrv detected	17
expiratory volume	17
significantly lower	17
distinct human	17
hrv infected	17
vp gene	17
clinical signs	17
rhinovirus replication	17
dna sequencing	17
less likely	17
reverse primer	17
wilcoxon signed	17
molecular techniques	17
syndrome coronavirus	17
york state	17
posted july	17
young adults	17
platelet counts	17
myocardial infarction	17
whole blood	17
nk cells	17
metapneumovirus infection	17
pcr amplification	17
atypical bacteria	17
health status	17
room temperature	17
family history	17
dietary intake	17
statistical analysis	17
infection control	17
smoking cessation	17
also collected	17
classifi ed	17
world health	17
table ii	17
immunosorbent assay	17
daily symptom	17
aged children	17
tract illness	17
large airway	16
immunosuppressed patients	16
may suggest	16
care facilities	16
pulmonary exacerbation	16
asthma rhinovirus	16
results showed	16
current study	16
also assessed	16
newly identifi	16
positively associated	16
median time	16
asthma hospitalizations	16
multiplex reverse	16
copd exacerbations	16
learning dimensionality	16
predictive values	16
asthma phenotypes	16
rna genome	16
used prior	16
confi dence	16
risk stratification	16
asthmatic epithelium	16
bronchial asthma	16
oral prednisolone	16
future studies	16
dendritic cells	16
pediatric outpatients	16
evidence indicates	16
density lipoprotein	16
higher rates	16
preterm children	16
written informed	16
steroid treatment	16
microbiological yield	16
patients presenting	16
inhibits rhinovirus	16
intestinal iga	16
airway diseases	16
cumulative incidence	16
conventional methods	16
virus types	16
rna virus	16
air pollutants	16
increased likelihood	16
better understanding	16
cell type	16
healthy volunteers	16
several studies	16
increased numbers	16
previous reports	16
reduced expression	16
tlr activation	16
pcr product	16
asthmatic airway	16
significantly increased	16
diagnostic yield	16
two methods	16
adult population	16
viral nucleic	16
pseudomonas aeruginosa	16
clinical outcome	16
novel group	16
another study	16
allergen challenge	16
preliminary data	16
low birth	16
wide range	16
symptom diaries	16
human rotavirus	16
new strains	16
three cases	16
pg ml	16
detected virus	16
international license	16
nucleotide identity	16
remain unclear	16
respiratory system	16
asthma development	15
reactive protein	15
upper airways	15
last months	15
air quality	15
short course	15
contact tracing	15
chest physicians	15
sense rna	15
less successful	15
gnotobiotic pig	15
may help	15
asthmatic compared	15
patient group	15
predicted fev	15
compared using	15
mouth disease	15
interstitial lung	15
atopic sensitization	15
cellular receptor	15
childhood wheezing	15
refl ex	15
pleural effusion	15
healthy non	15
important cause	15
cantly improved	15
recognition molecules	15
rna replication	15
research project	15
molecular epidemiological	15
effi cient	15
tissue samples	15
ml pgg	15
function testing	15
per year	15
sampling method	15
middle east	15
nasba assay	15
infections may	15
bead array	15
medical staff	15
twice daily	15
blood pressure	15
heart failure	15
lipoprotein receptor	15
comprehensive detection	15
often associated	15
severe illness	15
influenza vaccine	15
specific primers	15
severe bronchiolitis	15
also signifi	15
dence interval	15
genome sequence	15
available data	15
reference strains	15
health issue	15
normal spirometry	15
subjects underwent	15
sample entropy	15
bronchial responsiveness	15
expression levels	15
sequence alignment	15
gestational age	15
cytopathic effect	15
total number	15
quantifi able	15
gradient centrifugation	15
year follow	15
infl uenzae	15
illness episodes	15
study aims	15
death worldwide	15
among hospitalized	15
experimental infection	15
cell degranulation	15
complications occurred	15
drug delivery	15
ethics committee	15
single dose	15
infl uences	15
early adulthood	15
profi les	15
another virus	15
lung epithelial	15
airway hyper	15
bovine serum	15
amplifi cation	15
environmental factors	15
saline challenge	15
respiratory medicine	15
mucosal immune	15
ml pa	15
hay fever	15
patient demographics	15
asc responses	15
cough refl	15
animal models	15
negative predictive	15
relatively common	15
transcription factor	15
negative result	15
antibody titres	15
novel human	15
greater variability	15
life cycle	15
hrv pcr	15
strong positive	15
stable state	15
standard curve	15
antiviral therapy	15
remains high	14
dynamic hyperinfl	14
di amplitude	14
bore iccs	14
activity levels	14
half reported	14
performed two	14
pna positive	14
laryngeal behaviour	14
copd underwent	14
glycation end	14
mrna stability	14
extended culture	14
community hospitals	14
cell number	14
sputum testing	14
two antibodies	14
indoor air	14
rst time	14
unilateral tp	14
cough duration	14
starting using	14
normal vocal	14
number concentrations	14
prospectively followed	14
clinical pharmacist	14
pulmonary tb	14
pandemic specimens	14
lung elastic	14
results vocal	14
diagnostic sampling	14
dicarboxylic acids	14
na absorption	14
common causes	14
pilot data	14
cant bleeding	14
ranks test	14
luciferase activity	14
uenza alone	14
bone mineral	14
unexplained variation	14
maximal response	14
specifi ed	14
function laboratory	14
ca families	14
provides additional	14
cpap via	14
deep inspiration	14
alveolar macrophages	14
allergen challenges	14
major source	14
end products	14
fold increase	14
immediate bleeding	14
results thirty	14
methods consecutive	14
exercise session	14
increasing frequency	14
mesenchymal markers	14
advanced glycation	14
three groups	14
microbiological diagnosis	14
hours spent	14
rm anova	14
infected infants	14
clearance rates	14
selected consisting	14
nucleotidyl transfer	14
upa testing	14
test repetition	14
respiratory ward	14
novel imaging	14
whether eicosanoids	14
radiology department	14
reduced dynamic	14
primary cultures	14
virus positive	14
airway pretreatment	14
later age	14
dyspnoea scale	14
bronchodilator response	14
regression models	14
negative exacerbations	14
retrieval team	14
macrophage function	14
barwon health	14
medical conditions	14
smoke exposure	14
patients managed	14
streptococcus pneumoniae	14
service providers	14
ipaq ee	14
subjects subsequently	14
plasma cells	14
induces goblet	14
term colistin	14
dependent airways	14
clinical audit	14
major city	14
novel mask	14
following admission	14
treat asthma	14
thick sections	14
improved signifi	14
latent tuberculosis	14
actual mw	14
vp sequence	14
royal adelaide	14
average length	14
ion transport	14
health committee	14
pathway proteins	14
iet cytokines	14
lung luminescence	14
cellular migration	14
iet cells	14
lobar pneumonia	14
methods participants	14
brosis bronchiectasis	14
spearman correlations	14
airway sections	14
inhaled metal	14
cells infected	14
leak compared	14
using pcr	14
skin test	14
colistin patients	14
sheep model	14
isolated reduction	14
learning effect	14
normal mice	14
remains unclear	14
methods using	14
stable lung	14
cellular infl	14
ambient ultrafi	14
will inform	14
lung mechanics	14
steps recorded	14
patient groups	14
base call	14
less stable	14
poorly understood	14
examine laryngeal	14
genetic cluster	14
action plans	14
obstructive sleep	14
procedures performed	14
isolated human	14
bre intake	14
results subjects	14
equally effective	14
remaining procedures	14
multiparameter fl	14
supine posture	14
cc tlc	14
pb group	14
model provides	14
nasal lavage	14
causative agent	14
high frequency	14
myositis antibodies	14
mean ages	14
onset ar	14
enriched sub	14
uid motion	14
statistical difference	14
health board	14
commonest cause	14
participants underwent	14
long term	14
fvc ratio	14
referral centres	14
rage expression	14
positive contacts	14
regional patients	14
sv transcripts	14
healthy ageing	14
cxcl release	14
fi breoptic	14
rst child	14
uence expression	14
clinical diagnosis	14
clinical parameters	14
medicine trainees	14
chest wall	14
cant relationship	14
ndings suggest	14
cpap clinic	14
high proportion	14
oxygen desaturation	14
therapeutic targeting	14
protein deposition	14
using molecular	14
vibrating membrane	14
diagnostic procedure	14
culture protocol	14
intercostal catheter	14
exacerbation plans	14
sleep apnoea	14
shorter latency	14
parapneumonic effusions	14
likely due	14
medrxiv preprint	14
children requiring	14
invasive ct	14
bed days	14
pilot cross	14
inpatient prescriptions	14
care services	14
mixed granulocytic	14
transverse airway	14
abnormal glucose	14
sibling controls	14
exercise capacity	14
frequent upper	14
auckland city	14
day following	14
particle number	14
tropical countries	14
high incidence	14
patients cleared	14
receptor subtype	14
ventilation perfusion	14
interval training	14
slice ct	14
mitochondrial dysfunction	14
radiological fi	14
higher numbers	14
smoke extract	14
membrane nebulizers	14
cultured airway	14
airway wall	14
surfactant era	14
weekly intra	14
mean fl	14
exercise consisted	14
walk distance	14
expenditure activities	14
pig model	14
based tasmanian	14
graft iet	14
response using	14
subjects undergoing	14
english hospitals	14
current smokers	14
exercised twice	14
airway compliance	14
immunocompromised hosts	14
using multiparameter	14
support nil	14
current service	14
cytokines determined	14
mini kit	14
management algorithm	14
conclusion non	14
tissue disease	14
cant risk	14
pa dnase	14
medical wards	14
respiratory picornaviruses	14
carv infection	14
cant haemoptysis	14
fat intake	14
including device	14
slice computerized	14
colistin side	14
cytokine responses	14
airway segments	14
patients infected	14
venous access	14
use cpap	14
ar eczema	14
resonant frequency	14
confidence interval	14
device technique	14
tract samples	14
collected included	14
pulmonary infection	14
monitoring response	14
computerized tomography	14
versus monocytes	14
primer pair	14
respiratory pathogen	14
trend towards	14
tertiary referral	14
methods data	14
gold standard	14
may vary	14
requiring emergency	14
decreased signifi	14
district health	14
larynx quantifi	14
bacterial infection	14
key macrophage	14
right caudal	14
case review	14
nitrogen washout	14
ultrasound service	14
alfred niv	14
severe lower	14
indigenous status	14
medical ward	14
large pneumothorax	14
total ige	14
medication charts	14
sequence data	14
serotype information	14
children years	14
rage polymorphisms	14
wheezing illnesses	14
copd may	14
human bronchi	14
patients showed	14
asymptomatic infections	14
cantly increased	14
neutralising antibody	14
whilst nasal	14
commencing cpap	14
well tolerated	14
icc insertion	14
education program	14
cancer models	14
underwent lung	14
aberrant activation	14
ed frequent	14
increased graft	14
pa isolates	14
imaging technique	14
smear positive	14
hrv indices	14
normal speeds	14
pulse rate	14
dietetic review	14
intracellular cytokines	14
mask sampler	14
molecular characterization	14
ux symptoms	14
grant support	14
icc drainage	14
foundation wa	14
studies used	14
mechanisms may	14
related quality	14
identify sp	14
rage ligands	14
transcription polymerase	14
hour prior	14
signed ranks	14
nal pressure	14
chronic infl	14
infectious cough	14
cytometric bead	14
amplifi ed	14
optical density	14
dysfunction may	14
conducting airways	14
uncommon cause	14
ed mantoux	14
exercise sessions	14
ecm proteins	14
large bore	14
tuberculosis infection	14
lagged symptom	14
density gradient	14
hrv sequences	14
inpatients treated	14
pandemic proportion	14
nebulized colistin	14
mean scores	14
insertion details	14
followed since	14
phagocytose apoptotic	14
steps counted	14
cant reduction	14
respiratory paediatrician	14
clinical follow	14
pmh ed	14
lung capacity	14
speech therapy	14
multiple breath	14
ecm protein	14
lung transplantation	14
study group	14
extracellular matrix	14
di depends	14
nhmrc australia	14
age cohorts	14
isaac phase	14
high levels	14
lumbar spine	14
walk test	14
mice exposed	14
uenza infection	14
reported current	14
bronchodilator fev	14
degrading enzymes	14
underwent bronchoscopy	14
excessive narrowing	14
including hrv	14
potentially life	14
identified human	14
medical care	14
mantoux positive	14
infl iximab	14
cell lysates	14
hospital attendance	14
proven lrti	14
genetic clustering	14
pmh foundation	14
vq scans	14
macrophage phagocytosis	14
exercise training	14
viral titre	14
nonatopic asthma	14
particularly indigenous	14
systemic levels	14
shared bongs	14
estimate asm	14
icc treatment	14
seasonal influenza	14
gmf increased	14
nervous system	14
foreign bodies	14
connective tissue	14
seldinger icc	14
adelaide hospital	14
lung lobes	14
methods adult	14
lung challenges	14
large pneumothoraces	14
increased clsecretion	14
pack furniture	14
ventilatory response	14
viral infectivity	13
may increase	13
review board	13
family picornaviridae	13
isolates collected	13
adult volunteers	13
protective effect	13
aspergillus fumigatus	13
increased levels	13
among adults	13
pairwise nucleotide	13
linear regression	13
bronchial epithelium	13
antiviral drugs	13
high level	13
children human	13
allergen sensitization	13
induced aris	13
disease virus	13
neutralizing antibody	13
aged months	13
two studies	13
acquired respiratory	13
mg kg	13
crystal structure	13
community study	13
household members	13
multiple infections	13
rhinovirus detection	13
receptor group	13
reduced risk	13
platelet count	13
institutional review	13
nitrogen dioxide	13
independent risk	13
urban areas	13
wind velocity	13
antiviral compounds	13
virtual screening	13
southern brazil	13
chest radiographs	13
observational studies	13
inclusion criteria	13
national health	13
experimentally infected	13
year study	13
five years	13
different concentrations	13
aged years	13
infected children	13
relatively high	13
significant association	13
previously undetected	13
patients hospitalized	13
expiratory wheezing	13
vero cells	13
children younger	13
medical research	13
within hours	13
molecular diagnostics	13
positive group	13
nasal swab	13
new respiratory	13
epithelial damage	13
frequent detection	13
chart review	13
resequencing microarray	13
tract viral	13
relative risk	13
intervention group	13
viral exacerbations	13
asymptomatic infection	13
fi nding	13
sequence identity	13
commercially available	13
cases per	13
iii ifns	13
using conventional	13
one hundred	13
linked immunosorbent	13
whole genome	13
average temperature	13
airway resistance	13
frequent cause	13
including respiratory	13
among hrv	13
iga memory	13
randomised controlled	13
illness severity	13
diverse group	13
cytokine production	13
asthma among	13
cigarette smoking	13
viruses among	13
unrecognized human	13
longitudinal study	13
base calls	13
hrv activity	13
specific viral	13
requiring hospitalization	13
time nasba	13
three times	13
health organization	13
negative controls	13
virus families	13
pcr primer	12
children respiratory	12
antiviral responses	12
undetected hrv	12
dis doi	12
arg gly	12
starting material	12
cause severe	12
viral clearance	12
positive predictive	12
high degree	12
virus negative	12
cluster analysis	12
infect dis	12
developing asthma	12
younger children	12
hrv genotypes	12
young infants	12
nasopharyngeal swabs	12
accurate diagnosis	12
significantly greater	12
major risk	12
significantly reduced	12
treatment strategies	12
studies will	12
immune function	12
results also	12
international committee	12
average daily	12
mycoplasma pneumoniae	12
maternal smoking	12
gene polymorphisms	12
neutralizing antibodies	12
disease associated	12
east respiratory	12
increasing number	12
incubation period	12
infection rate	12
dependent manner	12
end probe	12
community respiratory	12
commonly detected	12
early detection	12
hrv genome	12
mrna levels	12
probably representing	12
atopic characteristics	12
infection occurred	12
asthma compared	12
causes asthma	12
studies showed	12
reported asthma	12
binding compounds	12
initial infection	12
patients treated	12
viral gastroenteritis	12
heart score	12
corticosteroid therapy	12
rapid diagnosis	12
viral illness	12
demographic characteristics	12
frequently associated	12
rna infectivity	12
influenza infection	12
subsequent development	12
cell line	12
kg day	12
infections due	12
elderly persons	12
th responses	12
allergen avoidance	12
hrv viral	12
patients died	12
study conducted	12
severe rsv	12
meteorological factors	12
picornavirus infections	12
care workers	12
variable selection	12
differentially expressed	12
monoclonal antibodies	12
based cohort	12
may affect	12
human epithelial	12
day care	12
negative results	12
analysis using	12
mouse models	12
randomized trial	12
human tracheal	12
associated hospitalizations	12
nasopharyngeal aspirate	12
longer duration	12
control groups	12
phase ii	12
hrv serotype	12
dynamic range	12
hrv single	12
like particles	12
suffi cient	12
novel coronavirus	12
respiratory epithelium	12
per cent	12
occupational asthma	12
genome characterization	12
asthma risk	12
lactiflora root	12
novel rhinovirus	12
wheezy bronchitis	12
children without	12
multiple viral	12
previously published	12
also reduced	12
antigen detection	12
two hundred	12
time point	12
lung injury	12
clinical use	12
viral agents	12
blood cultures	12
based methods	12
central role	12
aged less	12
uenza virus	12
natural infection	12
two different	12
cell numbers	11
genetic variability	11
mild asthma	11
positive correlation	11
rhinovirus transmission	11
antibody production	11
cell types	11
two doses	11
randomly selected	11
hospitalized wheezing	11
enteric viruses	11
lbw infants	11
single infection	11
viral shedding	11
cultures treated	11
coronavirus infections	11
early treatment	11
patients presented	11
subsequent asthma	11
nasopharyngeal washings	11
authors declare	11
within days	11
increased expression	11
within families	11
allergic asthma	11
viral protein	11
rhinovirus outbreak	11
asthma therapy	11
molecular evolution	11
chronic bronchitis	11
following infection	11
steroid resistance	11
wheezing rhinovirus	11
influenza vaccination	11
iga antibody	11
generation sequencing	11
immune activation	11
asthma education	11
two patients	11
tertiary care	11
inflammatory cytokines	11
fold higher	11
chronic pulmonary	11
without respiratory	11
molecular evolutionary	11
confounding factors	11
antibody levels	11
different serotypes	11
statistical significance	11
active smoking	11
may represent	11
asthmatic individuals	11
samples using	11
common viral	11
tracheal epithelial	11
syncytial viruses	11
increasingly recognized	11
seeplex rv	11
three hrv	11
adult asthma	11
reduction algorithms	11
older adults	11
first time	11
school children	11
atopic disease	11
hrv lrti	11
phylogenetic trees	11
illness episode	11
care units	11
induced allergic	11
mean numbers	11
experimental animals	11
infection induces	11
stepwise variable	11
time period	11
induced il	11
copies reaction	11
molecular diagnosis	11
ar arg	11
previous work	11
severe complications	11
mixed viral	11
hrv detections	11
acute upper	11
picornavirus infection	11
patient population	11
breast feeding	11
daily activities	11
also shown	11
tested negative	11
per day	11
acute expiratory	11
diagnostic criteria	11
common chronic	11
children enrolled	11
systemic lymphoid	11
least two	11
receptor binding	11
complete nucleotide	11
iii interferon	11
gel electrophoresis	11
human parvovirus	11
genetic analysis	11
intestinal lamina	11
clinical assessment	11
greater severity	11
clinical studies	11
genomic dna	11
dna viruses	11
negative samples	11
random hexamer	11
virol doi	11
investigated whether	11
excessive airway	11
additional studies	11
detect respiratory	11
communityacquired pneumonia	11
strains may	11
signaling pathways	11
supplemental material	11
fi nd	11
human studies	11
health effects	11
molecular level	11
mainly due	11
peer review	11
incidence rate	11
coronavirus nl	11
molecular mechanisms	11
multivariable model	10
ng ml	10
clinical management	10
negative control	10
disease exacerbations	10
pulmonary exacerbations	10
different types	10
new england	10
vp coding	10
tested using	10
calculated using	10
naturally acquired	10
antibody response	10
confi rm	10
cells per	10
neutrophilic airway	10
whose mothers	10
advisory committee	10
virus load	10
breaths min	10
hospital serdang	10
protein synthesis	10
surveillance system	10
epidemiological data	10
cells expressing	10
nasal secretion	10
phase three	10
epidemiological study	10
muscle cells	10
clinical significance	10
induced ari	10
recurrent exacerbations	10
respiratory complications	10
one third	10
cell memory	10
host defense	10
experimental studies	10
preterm infants	10
heart disease	10
cant association	10
moderately severe	10
infections often	10
bacterial colonization	10
different virus	10
previously known	10
usually associated	10
iii interferons	10
children clinical	10
environmental tobacco	10
infections caused	10
defi nition	10
diagnosed viral	10
total rna	10
infection among	10
tissue damage	10
molecular features	10
supplemental oxygen	10
sensitive molecular	10
known human	10
major pathogen	10
among patients	10
human immunodeficiency	10
serum antibody	10
induced lrtis	10
either rsv	10
growth factor	10
culture techniques	10
relative odds	10
high number	10
selective pressure	10
despite extensive	10
bronchial lavage	10
higher risk	10
less often	10
biopsy samples	10
affected children	10
viral induced	10
gastrointestinal tract	10
will provide	10
eosinophil count	10
patients required	10
hrv transmission	10
larger sample	10
human meta	10
bootstrap values	10
clinical care	10
novel target	10
diagnostic accuracy	10
categorical variables	10
common viruses	10
nasal spray	10
daily life	10
collaborative report	10
study demonstrates	10
asthma outcomes	10
familial predisposition	10
cell activity	10
induced airway	10
like strains	10
gastrointestinal symptoms	10
late stage	10
infants born	10
young adult	10
reaction detection	10
immunocompetent patients	10
single hrv	10
infections cause	10
best hit	10
household transmission	10
matrix metalloproteinase	10
cellular senescence	10
winter season	10
nhanes iii	10
human adenovirus	10
prick test	10
nasal mucosa	10
phylogenetic analyses	10
influenza season	10
enterovirus infection	10
animal studies	10
based assays	10
intestinal lymphoid	10
cohort followed	10
rhinovirus genus	10
outcome variable	10
chest radiograph	10
viral proteins	10
weeks gestation	10
bocavirus infection	10
vp sequencing	10
viral life	10
cytokine levels	10
drug treatment	10
healthy individuals	10
methacholine challenge	10
specific antibody	10
also used	10
small airway	10
structural features	10
time course	10
studies indicated	10
previously well	10
case report	10
mean optical	10
masstag polymerase	10
remains unknown	10
th cells	10
recombination events	10
reference laboratory	10
tropical areas	10
viral types	10
participants reported	10
per patient	10
effi cacious	10
paediatric respiratory	10
viral cause	10
expiratory flow	10
lavage samples	10
sole hrv	10
days prior	10
statistical analyses	10
distress syndrome	10
children presenting	10
additional respiratory	10
transmission events	10
different respiratory	10
among young	10
inoculated onto	10
genetically diverse	10
immunodeficiency virus	10
masstag pcr	10
joining method	10
longitudinal cohort	10
peak expiratory	10
bacterial culture	10
genus enterovirus	10
major site	10
severe ari	10
mortality associated	10
reference strain	10
airway hyperreactivity	10
lrti events	10
may protect	10
biological evaluation	10
newly discovered	10
predict subsequent	10
host innate	10
identify viruses	10
serum albumin	10
picornaviridae family	10
ohio hela	10
well plates	10
temperate climates	10
stool samples	10
children rhinovirus	10
outbreak orphanage	10
pandemic influenza	10
different time	9
van der	9
data including	9
culture medium	9
incidence rates	9
seasonal pattern	9
mice infected	9
patient management	9
protective role	9
infants suffering	9
reference sequences	9
thai children	9
hrv disease	9
little data	9
study using	9
sequence diversity	9
known hrv	9
symptomatic infection	9
skin prick	9
time polymerase	9
related morbidity	9
sars patients	9
asthma prevention	9
infection severity	9
reduced cell	9
pyrrolidine dithiocarbamate	9
children using	9
viral antigen	9
combination therapy	9
culture negative	9
american ginseng	9
inactivated vaccine	9
never smoked	9
fl uids	9
hrv antigen	9
bacterial respiratory	9
function abnormalities	9
limited value	9
using human	9
infant respiratory	9
patient characteristics	9
symptoms indicating	9
hrv may	9
rotavirus vaccine	9
retrospective analysis	9
ammatory markers	9
results compared	9
induced lung	9
using nasal	9
year prospective	9
ca subspecies	9
specific antibodies	9
infectious material	9
investigated using	9
strong association	9
amplicon sequencing	9
term effects	9
interbeat interval	9
new human	9
hrv illness	9
predict asthma	9
targeted therapy	9
airway epithelia	9
low incidence	9
low concentrations	9
respiratory outbreaks	9
autonomic nervous	9
growing body	9
mitochondrial function	9
one child	9
normal range	9
systematic reviews	9
host immunity	9
regulatory mechanisms	9
binding site	9
recently published	9
tight junction	9
single viral	9
often used	9
median number	9
protective mechanism	9
accession numbers	9
primary diagnosis	9
asthmatic bronchial	9
industrial population	9
patients without	9
putative new	9
samples obtained	9
possible lrti	9
expired volume	9
viruses identified	9
severe exacerbations	9
consecutive days	9
including patients	9
management program	9
function data	9
low rate	9
needle aspiration	9
infected cell	9
geographic distribution	9
acid sequences	9
vp regions	9
pathways involved	9
standard hrv	9
wide variety	9
sirt activator	9
based design	9
small intestinal	9
low density	9
healthy adults	9
gender differences	9
underlying conditions	9
validated using	9
grant number	9
one day	9
higher threshold	9
global initiative	9
pneumonia caused	9
nested multiplex	9
possible role	9
health services	9
highest levels	9
cultures without	9
tree reconstruction	9
early morning	9
clinical decision	9
many people	9
also reported	9
ethidium bromide	9
rotavirus infections	9
greater increase	9
routine use	9
severe clinical	9
data suggests	9
rank test	9
virus interference	9
using rt	9
nk cell	9
new species	9
flu infections	9
surrounding areas	9
less frequent	9
studies demonstrated	9
sars coronavirus	9
hrv strain	9
table i	9
genetics analysis	9
refl ects	9
symptoms associated	9
additional file	9
prototype sequence	9
molecular screening	9
remain poorly	9
health outcomes	9
influenza immunization	9
custom software	9
generally mild	9
acute myocardial	9
protein vp	9
two decades	9
response slope	9
diagnostic methods	9
geographic region	9
within week	9
required hospital	9
antiviral signalling	9
developed countries	9
dual infection	9
transcriptional activity	9
evolutionary genetics	9
infancy predict	9
one virus	9
standard pcr	9
sputum induction	9
coding sequences	9
gastrointestinal viruses	9
south wales	9
coronavirus infection	9
rna extracted	9
proinflammatory cytokines	9
life technologies	9
specimens obtained	9
contributing factor	9
matched control	9
low dose	9
signifi cance	9
infection rates	9
lockdown period	9
qiaamp viral	9
hand washing	9
foster city	9
relatively low	9
hrv genomes	9
new south	9
offi ce	9
lambda subtypes	9
direct elisa	9
conclusion hrv	9
increased rate	9
positively correlated	9
ned using	9
conserved among	9
scoring system	9
differential diagnosis	9
fold dilutions	9
patients diagnosed	9
coding sequence	9
incidence curves	9
group patients	9
time nucleic	9
living within	9
southern hemisphere	9
investigate whether	9
genetic predisposition	9
transport medium	9
bronchial washings	9
asthma remains	9
molecular beacon	9
remained stable	9
hyperimmune serum	9
medical attention	9
single infections	9
enterovirus rna	9
high morbidity	9
study carried	9
respiratory rate	9
outpatient clinics	9
emergency room	9
transcription factors	9
specifi cally	9
hrv induced	9
lambda levels	9
viral stocks	9
positive subjects	9
therapeutic approaches	9
cardiac events	9
adrenergic receptor	9
clinical context	9
oral pleconaril	9
study design	9
health service	9
clinical testing	9
viral pneumonia	9
analysis algorithm	9
close contact	9
random sample	9
human bronchial	9
antiviral immunity	9
increased use	9
within hrv	9
subsequent childhood	9
three multiplex	9
regular exercise	9
new approach	9
without affecting	9
following challenge	9
illness caused	9
classifi cation	9
ari cases	9
decreased risk	9
negative groups	9
streptococcus pyogenes	9
samples taken	9
mrc cells	9
human disease	9
related severe	9
hrv groups	9
less frequently	9
ct scans	9
critical importance	9
antimicrobial therapy	9
adaptive immune	9
cell protein	9
cold viruses	9
bronchial biopsies	9
routine diagnostic	9
autonomic function	9
human metapneumoviruses	9
twofold increase	9
human volunteers	9
negatively associated	9
control program	9
sequence divergence	9
university hospital	9
recent evidence	9
life predict	9
secreting cell	9
data sets	9
commonly found	9
volatile organic	8
participants received	8
additive effect	8
using mouse	8
often co	8
body weight	8
normal fl	8
rcv compared	8
study reports	8
hajj pilgrims	8
buffered saline	8
irreversible human	8
different species	8
japanese children	8
mean pressure	8
considered mostly	8
findings suggest	8
will improve	8
undergoing diagnostic	8
adults aged	8
become available	8
mucus hypersecretion	8
homing receptor	8
retrospectively reviewed	8
commonly affected	8
viral species	8
crystal structures	8
induced rhinovirus	8
variable among	8
molecular surveillance	8
either hrv	8
studies provide	8
improved outcomes	8
normal group	8
pcr kit	8
specific igg	8
infants hospitalized	8
viral titers	8
requiring hospital	8
hierarchical cluster	8
presenting symptoms	8
sputum eosinophils	8
hunter hospital	8
major symptoms	8
care system	8
position statement	8
aged days	8
whether changes	8