bigram

This is a table of type bigram and their frequencies. Use it to search & browse the list to learn more about your study carrel.

bigram	frequency
stem cell	2441
cell transplantation	1721
bone marrow	1290
class i	1275
blood donors	1149
peripheral blood	1039
blood transfusion	844
hematopoietic stem	838
mg kg	838
median age	803
overall survival	744
cd cells	743
whole blood	736
immune response	736
mhc class	716
class ii	705
acute gvhd	686
stem cells	679
patients received	679
conditioning regimen	668
cd cd	661
chronic gvhd	648
red blood	627
host disease	618
blood components	609
blood donation	598
median follow	588
cord blood	581
cell epitopes	559
study design	555
blood group	550
flow cytometry	538
red cell	537
blood products	506
summary conclusions	495
case studies	492
immune responses	489
median time	482
background case	481
free survival	479
nk cells	478
cell responses	474
hla class	473
one patient	459
blood cells	449
blood bank	444
immune system	437
high risk	426
risk factors	419
allogeneic hematopoietic	409
amino acid	408
significantly higher	405
gvhd prophylaxis	391
design method	387
allogeneic stem	385
results finding	375
transfusion medicine	368
ng ml	366
cumulative incidence	354
unrelated donor	349
blood cell	349
adverse events	335
red cells	335
significant difference	325
complete remission	325
blood donor	323
graft failure	321
blood stem	320
statistically significant	296
control group	296
allogeneic hsct	293
two patients	292
performed using	289
specific cd	288
patients receiving	282
dendritic cells	280
multivariate analysis	279
cell lines	279
blood samples	278
cell receptor	277
graft versus	274
patients undergoing	273
multiple myeloma	267
marrow transplantation	267
platelet concentrates	265
ex vivo	265
cd cell	264
i molecules	264
amino acids	258
cell activation	257
two groups	256
transfusion reactions	254
cell surface	254
platelet count	254
grade ii	253
intensity conditioning	252
reduced intensity	248
cell response	248
versus host	248
related mortality	245
acute rejection	244
myeloablative conditioning	240
cell epitope	237
autologous stem	234
significant differences	231
matched unrelated	228
transplant recipients	228
university hospital	227
myeloid leukemia	226
blood banks	225
acute myeloid	224
side effects	224
severe acute	222
unrelated donors	222
blood units	215
transfusion service	215
relapse mortality	214
major histocompatibility	214
cmv reactivation	214
gene expression	210
mononuclear cells	207
acute respiratory	203
conditioning regimens	203
significantly lower	203
years old	201
cell transplant	201
mg dl	201
risk factor	200
nk cell	200
clinical trials	198
acute leukemia	197
blood collection	196
infected cells	195
retrospective study	195
healthy donors	194
patients treated	194
lung transplantation	193
blood donations	192
respiratory syndrome	190
histocompatibility complex	189
blood supply	187
least one	187
blood center	187
adult patients	186
donor chimerism	186
grade iii	185
cell source	185
influenza virus	183
data suggest	181
cell line	180
antigen presentation	180
hla alleles	180
months post	178
binding affinity	177
viral load	175
first time	175
acute graft	174
high dose	174
iu ml	174
cell clones	173
kg day	172
umbilical cord	172
three patients	170
pg ml	169
immune reconstitution	168
increased risk	166
monoclonal antibodies	166
cell dose	166
hematopoietic cell	165
important role	165
present study	164
long term	164
monoclonal antibody	164
infectious diseases	164
type i	163
year os	163
pregnant women	162
quality control	161
clinical trial	161
results suggest	161
pediatric patients	160
vaccine design	159
viral infections	158
blood product	157
patients died	156
cell proliferation	156
disease status	156
vaccine development	155
patients without	155
patients transplanted	154
one year	154
aplastic anemia	153
days post	153
natural killer	152
human leukocyte	152
epithelial cells	151
four patients	151
retrospective analysis	150
disease progression	150
peptide binding	149
medical center	149
median number	146
transgenic mice	146
clinically significant	145
results findings	144
cell depletion	144
patients developed	144
total number	144
ii molecules	143
virus infection	143
matched sibling	143
bacterial contamination	143
blood services	142
graft survival	142
cd ra	141
cell lymphoma	141
blood safety	141
mean age	141
dose chemotherapy	139
haematopoietic stem	139
sibling donor	138
design methods	138
cmv infection	138
high levels	137
acute lymphoblastic	137
donor selection	137
transfusion services	137
five patients	137
leukocyte antigen	135
blood component	135
rheumatoid arthritis	134
rbc units	134
spike protein	134
body weight	134
sickle cell	134
cells kg	133
room temperature	133
significantly increased	133
autologous blood	132
presenting cells	132
autoimmune diseases	132
cell count	131
hematological malignancies	131
neutrophil engraftment	130
adverse reactions	130
mhc i	130
mhc molecules	129
specific antibodies	129
mycophenolate mofetil	129
adaptive immune	129
target cells	128
specific ctl	128
well tolerated	128
matched related	126
aml patients	126
platelet engraftment	125
lymphoblastic leukemia	125
lymph nodes	125
severe covid	124
humanized mice	124
pts received	123
may also	123
national blood	123
significantly reduced	123
red cross	123
platelet transfusion	123
cd expression	123
univariate analysis	122
innate immune	122
previously described	122
antigen processing	121
consecutive patients	121
among patients	121
post transplant	120
previous studies	120
statistical analysis	120
blood service	120
significantly associated	119
identical sibling	119
antiglobulin test	118
cell therapy	118
blood centers	118
cord uid	117
doc id	117
cell subsets	117
single center	117
time points	117
antibody screening	116
allogeneic sct	116
infectious complications	116
renal function	116
united states	115
significantly different	115
immunodeficiency virus	114
results show	114
informed consent	114
hla antibodies	113
viral infection	113
mouse model	113
response rate	112
year overall	112
results indicate	112
blood volume	111
body irradiation	111
cell types	111
iv acute	111
cell immunity	111
mixed chimerism	111
progressive disease	110
year old	110
total body	110
blood loss	110
hbv dna	110
six patients	110
surface expression	110
hodgkin lymphoma	110
fi rst	109
ctl epitopes	109
graft rejection	108
memory cd	108
risk patients	108
hla molecules	108
immune cells	107
intensive care	107
blood pressure	107
significant increase	107
copies ml	107
hsct recipients	106
rbc transfusion	106
positive cells	106
blood groups	106
donor type	106
human immunodeficiency	106
higher risk	106
clinical practice	106
retrospectively analyzed	105
nucleic acid	105
transplant related	105
two different	105
relapse rate	104
nkt cells	104
frozen plasma	104
chronic graft	104
ctl response	104
effector cells	103
positive results	103
spike glycoprotein	102
cells expressing	102
related donor	102
determine whether	101
autoimmune disease	101
cell disease	101
cytokine production	101
positive samples	101
ml min	101
last years	101
cell population	100
one case	100
haploidentical donor	100
residual disease	99
cell populations	99
patient died	99
graft function	99
patients underwent	98
per year	98
factor viii	98
dr expression	98
myelodysplastic syndrome	98
gene therapy	98
study period	98
tumor cells	97
kidney transplant	97
previously reported	97
relapse incidence	97
mg ml	97
wild type	97
mer peptides	96
hematologic malignancies	96
antigen presenting	96
health care	96
prospective study	96
renal failure	96
mm patients	96
spleen cells	96
general population	96
grade i	95
see table	95
patient received	95
analysis showed	95
allogeneic transplantation	95
time pcr	95
nervous system	95
adverse effects	95
lung transplant	95
clinical outcome	95
lupus erythematosus	94
transplant patients	94
partial response	94
blood mononuclear	94
within days	94
blood banking	94
progenitor cells	94
fresh frozen	94
antigen expression	93
healthy controls	93
gvhd grade	93
day post	93
blood transfusions	92
disease relapse	92
mortality rate	92
age years	91
full donor	91
cardiac surgery	91
complete response	91
cell depleted	91
patients showed	91
median duration	90
case report	90
inkt cells	90
transfusion therapy	90
eight patients	90
multiple sclerosis	90
hcv rna	90
seven patients	90
human cd	90
systemic lupus	89
hla matched	89
type ii	89
buffy coat	89
stimulating factor	89
transfusion practice	89
recent years	89
hiv infection	89
marrow transplant	89
data indicate	89
clinical outcomes	89
novel coronavirus	88
transfusion reaction	88
female donors	88
patient developed	88
first days	88
partial remission	87
related complications	87
neutralizing antibodies	87
based conditioning	87
allogeneic hct	86
lymph node	86
i ii	86
barr virus	86
celiac disease	85
line therapy	85
high level	85
endothelial cells	85
also observed	85
th cells	85
antibody screen	85
liver transplantation	85
active disease	85
significant reduction	84
central nervous	84
statistical significance	84
group system	84
first year	84
autologous hsct	83
population coverage	83
survival rate	83
logistic regression	83
i alleles	83
large number	83
age group	83
i binding	83
high frequency	83
time donors	82
low dose	82
regression analysis	82
toxic epidermal	82
hiv infected	82
massive transfusion	82
antibody responses	82
transplanted patients	82
cell function	81
results showed	81
induction therapy	81
epidermal necrolysis	81
critically ill	81
respiratory tract	81
ferritin levels	81
antibody response	81
plasma samples	81
may lead	81
infectious disease	81
last follow	81
platelet recovery	81
transcription factor	81
first line	80
flow cytometric	80
false positive	80
safe blood	80
neutrophil recovery	80
allograft rejection	80
immunosuppressive therapy	80
severe combined	79
signifi cant	79
growth factor	79
epitope prediction	79
lung injury	79
ctl responses	79
poor prognosis	79
disease free	79
results obtained	79
hbv infection	79
treatment option	79
animal models	79
hemolytic transfusion	79
cell death	78
pathogen inactivation	78
within hours	78
results demonstrate	78
median cd	78
none declared	78
deficient mice	78
prophylaxis consisted	78
donate blood	77
platelet transfusions	77
may contribute	77
effective treatment	77
analyzed using	77
donor lymphocyte	77
syndrome coronavirus	77
phase i	77
may occur	77
patients suffering	77
higher incidence	77
hla identical	77
cell repertoire	76
inflammatory response	76
phase ii	76
included patients	75
blood transplantation	75
voluntary blood	75
cell development	75
antigenic peptides	75
two years	75
transplant cyclophosphamide	75
positive control	75
molecular weight	75
signifi cantly	75
direct antiglobulin	75
complex class	74
donor age	74
cellular immune	74
nine patients	74
relapsed refractory	74
white blood	74
preliminary results	74
sjs ten	74
clinical symptoms	74
antibody identification	74
abstract withdrawn	74
survival rates	74
related donors	74
pathogen reduction	73
patients achieved	73
low risk	73
antithymocyte globulin	73
disease control	73
even though	73
study group	73
human papillomavirus	73
high incidence	73
term survival	73
minimal residual	73
died due	72
line treatment	72
serum ferritin	72
donor cells	72
infected patients	72
cell recognition	72
kidney transplantation	72
immune complexes	72
myeloma patients	72
iron deficiency	72
care unit	71
genomic dna	71
donor screening	71
severe disease	71
clinical data	71
patients presented	71
cd count	71
analysis revealed	71
low levels	71
heavy chain	71
mismatched unrelated	71
graft loss	70
data show	70
platelet counts	70
autologous hematopoietic	70
haploidentical transplantation	70
also found	70
sibling donors	70
sos vod	70
necrosis factor	70
liver disease	70
hemolytic anemia	70
rhd gene	69
recent studies	69
based vaccine	69
ill patients	69
mass spectrometry	69
declare background	69
underlying disease	69
like receptor	69
abo blood	69
protein expression	69
monoclonal anti	69
patients aged	69
cd positive	69
primary endpoint	69
first months	68
western blot	68
year period	68
inflammatory cytokines	68
serious adverse	68
growth factors	68
solid tumors	68
malignant disease	67
public health	67
cell counts	67
per patient	67
transfusion safety	67
mast cells	67
cells showed	67
vaccinia virus	67
lymphoma patients	67
host immune	67
severe aplastic	67
factors associated	67
bacterial infections	66
highly conserved	66
curative treatment	66
combined immunodeficiency	66
organ transplantation	66
platelet products	66
salvage therapy	66
term follow	66
widely used	66
buffy coats	66
chain reaction	66
clinical course	66
transfused patients	65
expressing cells	65
cd foxp	65
protective immunity	65
underwent allogeneic	65
polymerase chain	65
chronic rejection	65
autologous transplantation	65
medical records	65
high affinity	65
additive solution	64
clinically relevant	64
kcal mol	64
extensive chronic	64
disease activity	64
acute lung	64
graft source	64
within months	64
cfu ml	64
immune cell	64
organ failure	64
patients experienced	64
adoptive transfer	64
may provide	64
post hsct	63
male donors	63
undergoing allogeneic	63
per unit	63
mhc binding	63
taken together	63
hematopoietic cells	63
thymocyte globulin	63
mesenchymal stem	63
sle patients	63
median os	63
patients engrafted	63
patient population	63
healthy individuals	62
serum levels	62
fold increase	62
marrow failure	62
salt bridge	62
virus type	62
renal transplant	62
three months	62
mediated rejection	62
cell recovery	62
risk group	62
apheresis platelets	62
viral replication	62
first step	62
ii alleles	62
influenza viruses	62
hla typing	62
predictive value	62
indirect antiglobulin	62
cell receptors	62
signal transduction	62
rhce ce	61
per day	61
atg group	61
major cause	61
influenza vaccine	61
significantly better	61
predicted epitopes	61
viral proteins	61
innate immunity	61
herpes simplex	61
bact alert	61
mg day	61
sars coronavirus	61
significantly decreased	61
matched donor	61
one month	61
tumor necrosis	60
confidence interval	60
storage time	60
blood type	60
molecular mimicry	60
high prevalence	60
small number	60
peptide vaccine	60
study included	60
may play	60
plasma cells	59
prognostic factors	59
allogeneic haematopoietic	59
donor population	59
adverse event	59
years ago	59
solid organ	59
structural proteins	59
cytokine release	59
like receptors	59
time point	59
ebv reactivation	59
cell differentiation	59
commonly used	59
author funder	59
cd lymphocytes	59
granted medrxiv	59
family members	59
hydrogen bonds	59
mhc ii	58
three different	58
dependent manner	58
hemorrhagic cystitis	58
cd ro	58
neutrophil count	58
cobe spectra	58
prospective studies	58
thalassemia major	58
infected mice	58
refractory disease	58
binding peptides	58
underwent hsct	58
cells may	58
transfusion transmitted	58
hb level	58
blood management	58
plasma units	58
clinical features	58
quality management	58
specific immune	58
patients affected	57
mediated immunity	57
cd low	57
kir dl	57
treatment related	57
cox regression	57
treated cells	57
septic shock	57
three times	57
cell transfusion	57
primary immunodeficiency	57
occlusive disease	57
fludarabine mg	57
allogeneic blood	57
unrelated cord	57
based vaccines	57
mononuclear cell	57
plasma exchange	57
advanced disease	57
rbc transfusions	57
specific cytotoxic	57
dendritic cell	56
regional blood	56
two cases	56
haploidentical hsct	56
ii binding	56
donor samples	56
nucleated cells	56
real time	56
binding groove	56
donated blood	56
bl mice	56
host cells	56
supplementary table	56
column agglutination	56
serum creatinine	56
platelets stored	56
i molecule	56
malignant diseases	55
five years	55
cell cycle	55
quality assurance	55
mycobacterium tuberculosis	55
hospital transfusion	55
months later	55
cohort study	55
johnson syndrome	55
negative blood	55
hcv infection	55
invasive fungal	55
findings suggest	55
repeat donors	55
copyright holder	55
mrna expression	55
reference laboratory	55
developed acute	55
older patients	55
recombinant human	55
complement activation	54
packed red	54
median days	54
cyclophosphamide mg	54
world health	54
adaptive immunity	54
derived peptides	54
rare blood	54
six months	54
year cumulative	54
negative control	54
haploidentical donors	54
scansystem tm	54
preliminary data	54
elderly patients	54
alternative donor	54
cell mobilization	54
may result	54
patient blood	54
vaccine candidates	54
fungal infection	54
general hospital	54
donor blood	54
ml kg	53
patient samples	53
higher levels	53
human immune	53
cells per	53
positive dat	53
transplant centers	53
dress dihs	53
cell viability	53
may cause	53
inflammatory bowel	53
significant decrease	53
previously shown	53
two weeks	53
center experience	53
progression free	53
abo rh	53
working party	53
information system	53
remaining patients	53
blood centre	53
may help	53
adverse reaction	53
trend towards	53
iron overload	53
clinical use	53
ric allo	53
peptides derived	53
escherichia coli	53
melphalan mg	53
cd kg	53
regimen consisted	53
transplant outcomes	53
single nucleotide	53
old male	53
tested using	53
expression levels	53
commercially available	52
limited number	52
allele frequency	52
group antigens	52
study shows	52
allogeneic bone	52
cell separator	52
cell numbers	52
stromal cells	52
iv agvhd	52
version posted	52
developed grade	52
respiratory distress	52
time period	52
clinical characteristics	52
viral reactivation	52
underwent allo	52
old female	52
second transplant	52
well established	52
elispot assay	52
blood system	52
family donor	52
inclusion criteria	52
generation sequencing	52
mds patients	52
respiratory failure	52
term outcome	52
trima accel	51
also performed	51
human mhc	51
treated patients	51
trauma patients	51
storage period	51
serum samples	51
severe chronic	51
cell concentrates	51
host cell	51
hla allele	51
binding site	51
month period	51
hemolytic disease	51
antibody titers	51
th day	51
single donor	51
following allogeneic	51
cells specific	51
target cell	51
cervical cancer	51
drug reactions	50
family donors	50
primary graft	50
synthetic peptides	50
cell antigens	50
severe gvhd	50
response rates	50
median day	50
allergic reactions	50
treated rbcs	50
classical monocytes	50
kg bw	50
apheresis platelet	50
cmv disease	50
terumo bct	50
virus replication	50
pts died	50
three years	50
made available	50
cells ml	50
trial registry	50
dna vaccine	50
current study	50
measured using	50
year post	50
age groups	50
patients diagnosed	50
plt count	50
clinical significance	50
vg vd	50
fetal dna	50
mechanical ventilation	50
critical role	50
cd high	49
low hb	49
increased expression	49
helper cells	49
cell collection	49
agvhd grade	49
well known	49
blood sample	49
tyrosine kinase	49
cell units	49
kg cd	49
similar results	49
autologous peripheral	49
several studies	49
positive donors	49
humoral immune	48
diagnostic criteria	48
severe cgvhd	48
standard deviation	48
united kingdom	48
study showed	48
second line	48
myeloid leukaemia	48
units per	48
effector memory	48
patient age	48
platelet antigens	48
allograft survival	48
overall response	48
antigen receptor	48
blood establishments	48
platelet units	48
undergoing hsct	48
refractory acute	48
spectra optia	48
mediated immune	48
patient safety	48
window period	48
quantitative pcr	48
defi ned	48
fully automated	47
risk score	47
post transfusion	47
cell mediated	47
bu cy	47
positive patients	47
may represent	47
autologous sct	47
progenitor cell	47
differential diagnosis	47
haploidentical transplant	47
reactive arthritis	47
hazard ratio	47
rhd negative	47
test results	47
key role	47
year survival	47
systematic review	47
colony stimulating	47
different hla	47
disease severity	47
low cd	47
male patients	47
positive correlation	47
gel test	47
peripheral stem	47
apheresis procedures	47
achieved cr	47
chronic myeloid	47
liver transplant	47
cellular immunity	47
leukemia patients	47
molecular mechanisms	47
ten patients	47
patients relapsed	47
molecular docking	47
cik cells	47
analysis using	47
haploidentical stem	47
significant impact	46
positive donations	46
infected individuals	46
patients may	46
clinical studies	46
rank test	46
platelet storage	46
consecutive days	46
ifitm ifitm	46
using flow	46
connective tissue	46
bk virus	46
center background	46
antigen specific	46
significant antibodies	46
simplex virus	46
rhd genotyping	46
mer peptide	46
proinflammatory cytokines	46
protein sequences	46
high mortality	46
acid sequence	46
high rate	46
relatively high	46
apoptotic cells	46
positive result	46
chronic granulomatous	46
study aimed	46
granulomatous disease	46
specific antibody	46
calcineurin inhibitors	46
replacement therapy	46
i hla	45
diffuse large	45
binding affinities	45
evaluated using	45
retrospective review	45
salvage treatment	45
high expression	45
significant risk	45
transmitted infections	45
done using	45
cancer patients	45
one patients	45
therapeutic plasma	45
life threatening	45
secondary graft	45
therapeutic option	45
birth weight	45
solid phase	45
clinical manifestations	45
hsct patients	45
listeria monocytogenes	45
cell memory	45
pilot study	45
high resolution	45
endoplasmic reticulum	45
single cell	45
newly diagnosed	45
university medical	45
years post	45
cell culture	44
patient care	44
high density	44
lymphocyte responses	44
platelet function	44
epitope discovery	44
platelet pools	44
low level	44
will help	44
many patients	44
uric acid	44
severe thrombocytopenia	44
supportive care	44
renal transplantation	44
higher number	44
extracorporeal photopheresis	44
least two	44
related toxicity	44
abdominal pain	44
blood grouping	44
i mhc	44
blood screening	44
bacterial growth	44
zika virus	44
breast cancer	44
cell number	44
double null	44
naturally processed	44
hbc positive	44
hct recipients	44
cell reconstitution	44
intravenous immunoglobulin	44
fungal infections	44
patient survival	44
data demonstrate	44
cell type	44
will also	44
immune dysregulation	44
flow cytometer	44
peptide sequences	44
one hundred	44
wide range	44
per kg	44
cd antibody	44
prognostic factor	43
positive antibody	43
iron depletion	43
plasma membrane	43
risk cytogenetics	43
sequence analysis	43
university school	43
assessed using	43
weight loss	43
high throughput	43
ko mice	43
molecular basis	43
clinical response	43
cd depleted	43
sample size	43
increased susceptibility	43
transcription factors	43
high sensitivity	43
adverse drug	43
immunogenic epitopes	43
female patients	43
facs analysis	43
virus infections	43
iron stores	43
broad spectrum	43
received myeloablative	43
platelet concentrate	43
high titer	43
cells within	43
kg body	43
data analysis	43
among blood	43
bowel disease	43
normal range	43
independently associated	43
donor source	43
grade iv	43
molecular biology	43
determined using	42
performance status	42
safety profile	42
immune suppression	42
disclosure background	42
female donor	42
molecular dynamics	42
allele frequencies	42
older age	42
significant correlation	42
underwent asct	42
lymphocyte count	42
crucial role	42
bronchiolitis obliterans	42
authors declare	42
immune deficiency	42
cd deficiency	42
epitope mapping	42
younger patients	42
gastrointestinal tract	42
vast majority	42
highly immunogenic	42
alloimmune thrombocytopenia	42
patient characteristics	42
research funding	42
successfully treated	42
stable disease	42
common cause	42
macrophage activation	42
ifitm double	42
preparative regimen	42
restricted epitopes	42
specific ctls	42
health organization	42
resident memory	42
human platelet	42
cell products	42
severe patients	42
transplant period	42
coronavirus disease	42
null cells	42
late effects	42
lymphocyte infusion	42
cryopreserved grafts	41
received allogeneic	41
human populations	41
killer cells	41
i antigens	41
effi cacy	41
chronic phase	41
risk acute	41
synovial fluid	41
risk aml	41
autoimmune hemolytic	41
table shows	41
investigated whether	41
drb alleles	41
vod sos	41
closely related	41
may affect	41
calculated using	41
maintenance therapy	41
rich plasma	41
platelet yield	41
inflammatory cytokine	41
routine use	41
negative results	41
cell antigen	41
better understanding	41
potential risk	41
plasma levels	41
received hsct	41
curative option	41
selection criteria	41
cells infused	41
i antigen	41
quality system	40
animal model	40
coagulation factors	40
viral loads	40
antifungal prophylaxis	40
treated mice	40
median dose	40
significant improvement	40
three groups	40
donor cell	40
healthy volunteers	40
hla binding	40
group compared	40
sanger sequencing	40
following hsct	40
allogeneic transplant	40
eleven patients	40
recipient age	40
renal disease	40
restricted cd	40
days later	40
lung allograft	40
different time	40
producing cells	40
gvhd occurred	40
transfusion center	40
main cause	40
igg antibodies	40
reverse vaccinology	40
transfusion related	40
two distinct	40
myeloid cells	40
patients compared	40
donor recruitment	40
binding prediction	40
relapse risk	40
immunosuppressive treatment	40
mhc molecule	40
killer cell	40
better understand	40
epitope vaccine	40
compatible blood	40
cell infusion	39
blood cultures	39
early post	39
overall mortality	39
donor recipient	39
medical record	39
clinical signs	39
peptide epitopes	39
mouse models	39
iron supplementation	39
plasma cell	39
ucb units	39
health status	39
human peripheral	39
transfusion practices	39
blood count	39
observational study	39
future studies	39
cells express	39
seasonal influenza	39
neutropenic fever	39
selected patients	39
tested positive	39
treg cells	39
statistical difference	39
htlv i	39
restriction elements	39
management system	39
drug hypersensitivity	39
showed significant	39
anti hpa	39
marrow cells	39
post transplantation	39
drug reaction	39
antibody mediated	39
significant proportion	39
cellular rejection	39
hb levels	39
reactive protein	39
peptide pools	39
mainly due	39
activated cd	39
past years	39
treatment options	39
group systems	39
recipient pairs	39
induction chemotherapy	39
studies showed	38
also used	38
mice immunized	38
lymphocyte infusions	38
platelet quality	38
large numbers	38
one week	38
american red	38
central venous	38
immune escape	38
retrospectively reviewed	38
gamma globulin	38
acid sequences	38
primary immunodeficiencies	38
recurrent infections	38
control groups	38
nkt cell	38
data collected	38
significantly improved	38
czech republic	38
tumor cell	38
density multiepitope	38
epitopes derived	38
surface markers	38
european countries	38
surface antigen	38
neonatal alloimmune	38
scd patients	38
mean number	38
type diabetes	38
study demonstrates	38
mast cell	38
probably due	38
bacterial infection	38
also known	38
study population	38
therapeutic approach	38
hospital blood	38
protective immune	38
regression model	37
disease risk	37
time blood	37
aldrich syndrome	37
candidate peptides	37
cancer cells	37
ctl escape	37
mobilized peripheral	37
per month	37
recent study	37
new york	37
healthy subjects	37
enzyme treated	37
vitro studies	37
bacterial screening	37
normal levels	37
converting enzyme	37
infectious agents	37
febrile neutropenia	37
salt bridges	37
centre experience	37
lg ml	37
specific anti	37
high quality	37
standard treatment	37
specific hla	37
patient groups	37
hla antigens	37
low frequency	37
patients required	37
using two	37
next generation	37
published data	37
entire cohort	37
nd allo	37
haemolytic disease	37
medical university	37
tm platelet	36
human cells	36
fully matched	36
cellular therapy	36
international license	36
first complete	36
igg levels	36
ethnic groups	36
platelet refractoriness	36
ctl epitope	36
haematological malignancies	36
infectious virus	36
also significantly	36
median survival	36
compared using	36
better os	36
mixed lymphocyte	36
mean time	36
transfusion associated	36
remained stable	36
patient group	36
higher cd	36
infl uence	36
also tested	36
potentially curative	36
virus release	36
performed according	36
acid residues	36
received allo	36
lymphoproliferative disease	36
steroid refractory	36
transfusion recipients	36
platelet concentration	36
vaccine candidate	36
viral variants	36
positive selection	36
hospital stay	36
transplant outcome	36
vs days	36
phase iii	36
two types	36
binding domain	36
platelet kit	36
skin lesions	36
jazz pharmaceuticals	36
cell replete	36
allowed us	36
high degree	36
lower incidence	36
human genome	36
information security	36
tcr repertoire	36
retrospectively evaluated	36
randomly selected	36
randomized trial	36
research center	36
avian influenza	36
rheumatic diseases	35
liver failure	35
two days	35
immune epitope	35
prospective randomized	35
antibody detection	35
first day	35
scoring system	35
viral inactivation	35
curative therapy	35
chemotherapy followed	35
cell yield	35
improved survival	35
viral antigens	35
reperfusion injury	35
west nile	35
risk assessment	35
autologous transplant	35
central role	35
gene polymorphisms	35
significant association	35
potential vaccine	35
patients included	35
also analyzed	35
protein synthesis	35
final concentration	35
rhd positive	35
systemic symptoms	35
linear regression	35
therapeutic strategies	35
term survivors	35
patients will	35
bacterial detection	35
icu admission	35
adoptively transferred	35
donor base	35
inhibitory effect	35
control samples	35
ii expression	35
side effect	35
one unit	35
year follow	34
single centre	34
relapse rates	34
basic protein	34
leukemic cells	34
hydrogen bond	34
i expression	34
antibody production	34
hospitalized patients	34
times higher	34
cell compartment	34
term outcomes	34
comorbidity index	34
experimental data	34
working group	34
vitro quality	34
cd mab	34
cell immune	34
multicenter study	34
chimeric antigen	34
poorly understood	34
immunized mice	34
binding sites	34
neutralizing antibody	34
new donors	34
signaling pathways	34
average number	34
previously demonstrated	34
influenza vaccines	34
male patient	34
mean hb	34
cross blood	34
low incidence	34
laboratory testing	34
engraftment occurred	34
per week	34
significant changes	34
corrective actions	34
different blood	34
abstract already	34
donor group	34
significantly correlated	34
developed chronic	34
nk receptors	34
blood cd	34
already published	34
multiepitope protein	34
last two	34
multivariate cox	34
protective effect	34
cgvhd patients	34
staphylococcus aureus	34
serum albumin	34
peptides presented	34
renal allograft	34
collected data	34
pts receiving	34
plasma fractionation	34
serological testing	34
patient cohort	34
except one	34
epitope database	34
severe sepsis	34
granulocyte colony	34
cell migration	33
organ transplant	33
allogeneic donors	33
different cell	33
total blood	33
papillomavirus type	33
cd bright	33
memory cells	33
regression models	33
independent risk	33
cumulative incidences	33
blood lymphocytes	33
showed significantly	33
rabbit anti	33
reagent lots	33
results indicated	33
vivo expansion	33
receptor binding	33
confirmed positive	33
young children	33
higher frequency	33
cytometric analysis	33
extremely rare	33
blot analysis	33
median interval	33
synthetic peptide	33
negative impact	33
electronic medical	33
presentation pathway	33
also associated	33
randomized controlled	33
scid mice	33
lactate dehydrogenase	33
yellow fever	33
intermediate risk	33
human population	33
aged years	33
antiviral therapy	33
following transplantation	33
donor transplants	33
days vs	33
severe cases	33
total nucleated	33
specific primers	33
complete donor	33
regulatory cells	33
normal rhd	33
promising results	33
tissue damage	33
viral rna	33
spike proteins	33
national institute	33
residual risk	33
mean platelet	33
salvage chemotherapy	33
high doses	33
total dose	33
platelet activation	33
emerging infectious	33
release syndrome	33
last decade	33
wbc count	33
donor center	33
hiv positive	33
thrombotic microangiopathy	33
clinical relevance	33
negative patients	33
samples collected	33
humanized mouse	33
ric regimen	33
event free	33
relatively low	33
volume reduction	33
antibiotic therapy	33
regular blood	33
group i	33
russian federation	32
still alive	32
liposomal peptides	32
escape mutations	32
protein antigens	32
different types	32
activation markers	32
viral clearance	32
myelin basic	32
may explain	32
major role	32
cells transplantation	32
lower levels	32
large scale	32
total cd	32
expressing cd	32
analyzed patients	32
freshly isolated	32
increased incidence	32
patients requiring	32
remains unclear	32
one study	32
normal controls	32
matched donors	32
patient showed	32
samples tested	32
group received	32
will allow	32
donating blood	32
high grade	32
chronic inflammation	32
clinical background	32
blood flow	32
crystal structure	32
increased significantly	32
standard operating	32
single amino	32
cells derived	32
expression level	32
cell free	32
previously published	32
abo incompatibility	32
molecular methods	32
serum igg	32
conditioning therapy	32
absolute number	32
web server	32
mm tris	32
middle east	32
short course	32
antibody tests	32
inflammatory responses	32
conventional chemotherapy	32
ferritin level	32
based regimen	32
shelf life	32
primary refractory	32
chronic inflammatory	32
endothelial cell	32
controlled trial	32
lymphocyte subsets	32
dengue virus	32
cancer immunotherapy	32
currently available	32
also showed	32
obstruction syndrome	32
weeks post	32
early phase	32
units transfused	32
hla system	32
hpa antibodies	32
culture system	32
platelet components	32
analysis demonstrated	32
normal mice	32
cells obtained	32
live attenuated	32
standard methods	31
acute cellular	31
antifungal therapy	31
three days	31
nkg dl	31
patient underwent	31
new blood	31
light chain	31
ligand incompatibility	31
cd monoclonal	31
data collection	31
laboratory tests	31
gold standard	31
studies suggest	31
nucleotide polymorphisms	31
days prior	31
restricted ctl	31
cd dose	31
study aims	31
first two	31
received one	31
membrane protein	31
using different	31
two pts	31
highly effective	31
tube method	31
apheresis procedure	31
blood bags	31
dna samples	31
also included	31
hemoglobin levels	31
reported cases	31
treatment failure	31
peptide sequence	31
peer review	31
surviving patients	31
clinical presentation	31
may induce	31
healthy donor	31
mortality rates	31
blood derived	31
deferred donors	31
data support	31
human serum	31
cell infiltration	31
nod card	31
adoptive immunotherapy	31
hemoglobin level	31
positive blood	31
ctl clones	31
poor outcome	31
short term	31
ii hla	31
nile virus	31
risk groups	31
nitric oxide	31
cd cytotoxic	31
nonrelapse mortality	31
infused cd	31
female patient	31
survival benefit	31
cd antibodies	31
fold higher	31
surface area	31
proliferative response	30
monocytes macrophages	30
igm antibodies	30
donor specific	30
nat screening	30
nucleic acids	30
obliterans syndrome	30
irradiated blood	30
cytogenetic risk	30
tertiary care	30
cytokine secretion	30
likely due	30
operating procedures	30
reagent red	30
humoral immunity	30
wt mice	30
serious complication	30
clinical improvement	30
cd monocytes	30
human hla	30
differ significantly	30
chronic hepatitis	30
adhesion molecules	30
myelogenous leukemia	30
lamina propria	30
acute phase	30
cells play	30
cold storage	30
control study	30
antibodies directed	30
aml mds	30
surface antigens	30
lymphoproliferative disorders	30
cd memory	30
mean value	30
orf ab	30
received peripheral	30
cell growth	30
agglutination technology	30
specific memory	30
leading cause	30
binding energy	30
exact test	30
young people	30
highly variable	30
ebv infection	30
cells stimulated	30
transfusion protocol	30
fusion protein	30
kir ligand	30
group antigen	30
research institute	30
overlapping peptides	30
viral epitopes	30
increased levels	30
myocardial infarction	30
reactive cd	30
normal human	30
antibody levels	30
may serve	30
viral peptides	30
chronic lymphocytic	30
white cell	30
peptide complexes	30
refractory patients	30
calcineurin inhibitor	30
diabetes mellitus	30
many countries	30
cytotoxic activity	30
may reduce	30
severe infections	30
clinical setting	30
san diego	30
longer follow	30
sinusoidal obstruction	30
immunodominant epitopes	30
fluorescence intensity	30
immune recovery	30
pulmonary edema	30
single unit	30
one day	30
invasive aspergillosis	30
gvl effect	30
study suggests	30
patient identification	30
ct scan	30
identifi ed	30
surgical procedures	30
protein structure	29
ankylosing spondylitis	29
increased mortality	29
mayo clinic	29
novel approach	29
heart failure	29
rbc antigens	29
cell expansion	29
one donor	29
third party	29
stage iii	29
effective therapy	29
received dli	29
derived cells	29
fl udarabine	29
every months	29
immune status	29
cov spike	29
data bank	29
cell product	29
histocompatibility antigens	29
hot spots	29
multiorgan failure	29
group vs	29
poor graft	29
human lung	29
new therapeutic	29
next step	29
multivariate analyses	29
cell alloreactivity	29
ii peptides	29
described previously	29
subunit vaccines	29
mcg kg	29
high rates	29
also evaluated	29
previous study	29
immune evasion	29
interferon gamma	29
haematopoietic cell	29
induced arthritis	29
cell grafts	29
ms patients	29
useful tool	29
old woman	29
negative controls	29
acute leukaemia	29
peptide complex	29
data obtained	29
cell separators	29
post sct	29
epithelial cell	29
intestinal gvhd	29
related acute	29
plasma products	29
liquid nitrogen	29
posted october	29
positive rate	29
day mortality	29
early diagnosis	29
pivotal role	29
threatening complication	29
retrospectively analysed	29
major challenge	29
less frequent	29
multivariable analysis	29
studied patients	29
mice showed	29
treated group	29
elevated levels	29
limiting dilution	29
transplant characteristics	29
developed agvhd	29
inventory management	29
high cd	29
transfusion vol	29
severe complications	29
significantly less	29
achieved complete	29
recent data	29
clinical impact	29
male female	29
samples obtained	29
vasovagal reactions	29
cells increased	29
proliferative responses	29
cytokine storm	29
automated blood	29
higher prevalence	29
common hla	29
international society	29
cox proportional	29
cell antibodies	29
compatibility testing	29
cytokine levels	29
liver toxicity	29
circulatory overload	29
important cause	29
two units	29
donor deferral	29
national health	29
abo typing	29
risk reduction	29
blood culture	29
screening test	29
hla haplotype	29
regular donors	29
wound healing	29
pregnant woman	29
rare donor	29
cmv viremia	28
short period	28
lymphocytic leukemia	28
poor mobilizers	28
ml per	28
transfusion policy	28
hematological diseases	28
receptor expression	28
blood collected	28
eligible patients	28
copy number	28
investigate whether	28
genes encoding	28
genetic polymorphisms	28
hong kong	28
ebola virus	28
hev rna	28
liquid chromatography	28
mild covid	28
i heavy	28
per rbc	28
post irradiation	28
pretransfusion testing	28
may reflect	28
good partial	28
different mhc	28
may improve	28
patient experienced	28
kidney recipients	28
myelodysplastic syndromes	28
cytometry analysis	28
th response	28
risk mds	28
beta thalassemia	28
surgery patients	28
anchor residues	28
pdb id	28
transplant center	28
elispot assays	28
transfusion chain	28
storage lesion	28
low rate	28
routinely used	28
final product	28
eligibility criteria	28
acute infection	28
three pts	28
deceased donor	28
rhd typing	28
immunocompromised patients	28
drug delivery	28
coronavirus infection	28
cancer center	28
will provide	28
blood progenitor	28
bleeding patients	28
well defined	28
aplastic anaemia	28
myeloablative allogeneic	28
thalassemic patients	28
increased frequency	28
western blotting	28
acute renal	28
statistical analyses	28
ii antigen	28
drug eruptions	28
ebmt registry	28
related adverse	28
single dose	28
manual tube	28
malignant cells	28
case reports	28
children aged	28
medical staff	28
living donor	28
high number	28
mhc complex	28
electron microscopy	28
human blood	28
developed countries	28
two months	28
naturally occurring	28
medrxiv preprint	28
fibrin glue	28
viral particles	28
autoimmune disorders	28
two major	28
potential therapeutic	28
hematopoietic recovery	28
preemptive therapy	28
may require	28
treatment modality	28
least months	28
organ dysfunction	28
results confirm	28
nucleated cell	28
post allo	28
successful treatment	28
first report	28
one single	28
ms ms	28
platelet additive	27
donor safety	27
therapeutic potential	27
large volume	27
major complication	27
second hsct	27
median overall	27
haemolytic anaemia	27
cells using	27
two samples	27
studies show	27
overall incidence	27
developed cmv	27
possible role	27
peptide pool	27
developed severe	27
different stages	27
lymphoid organs	27
renal impairment	27
molecular typing	27
cell sorting	27
study will	27
adhesion molecule	27
cell cross	27
phase study	27
two independent	27
findings indicate	27
consecutive adult	27
hla matching	27
single institution	27
control mice	27
control patients	27
ischemia reperfusion	27
gag processing	27
lower risk	27
human plasma	27
blood unit	27
donor lymphocytes	27
without significant	27
different countries	27
distress syndrome	27
group ab	27
group patients	27
plasma derivates	27
clinical condition	27
plt transfusions	27
hours post	27
draining lymph	27
negative selection	27
cost effective	27
reverse transcriptase	27
th cytokines	27
conserved epitopes	27
islet allograft	27
center study	27
remission status	27
vaccine construct	27
dc leu	27
cell subset	27
binding assays	27
acid testing	27
pcr amplification	27
rabbit atg	27
detection limit	27
using standard	27
less severe	27
mesenchymal stromal	27
rhd exons	27
cell donors	27
paediatric patients	27
predicted binding	27
clinical settings	27
identical siblings	27
data suggests	27
recipient mice	27
confidence intervals	27
absolute neutrophil	27
repeat blood	27
en el	27
effective vaccine	27
post asct	27
odds ratio	27
mhc complexes	27
binding predictions	27
dose tbi	27
cell clone	27
antigenic determinants	27
hla genes	27
specific immunity	27
decreased significantly	27
plasma transfusion	27
plasma volume	27
may influence	27
healthy blood	27
specific antigens	27
cell level	27
cd ratio	27
breast milk	27
also examined	27
sct group	27
internal medicine	27
i restricted	27
automated system	27
surface molecules	27
predicted peptides	27
still remains	27
beam group	27
meier method	27
goat anti	27
high titers	27
inhibitory receptor	26
genes involved	26
developing countries	26
mhc alleles	26
cell carcinoma	26
tested negative	26
decision making	26
graft dysfunction	26
provide evidence	26
overlapping peptide	26
based gvhd	26
risk disease	26
fatality rates	26
among different	26
first case	26
patients responded	26
frequently used	26
gene products	26
invariant chain	26
hla supertypes	26
transfusion testing	26
many studies	26
autosomal recessive	26
immunosuppressive regimen	26
beneficial effect	26
oral mucositis	26
cd selected	26
cell membrane	26
clinical efficacy	26
statistically different	26
polyclonal anti	26
component therapy	26
retrospective cohort	26
immunosuppressive agents	26
blood establishment	26
recently reported	26
binding motifs	26
generated using	26
laboratory parameters	26
fluorescence microscopy	26
disease recurrence	26
systemic involvement	26
protein data	26
mechanisms involved	26
hematopoetic stem	26
based regimens	26
antigen recognition	26
limited data	26
physical examination	26
mice treated	26
intercept blood	26
strongly associated	26
highly active	26
genetic factors	26
also shown	26
early detection	26
wide variety	26
one hla	26
structural basis	26
chemokine receptor	26
transfusion support	26
molecular analysis	26
heart transplantation	26
kinase inhibitors	26
complete blood	26
national university	26
relapsed disease	26
dose therapy	26
cardiovascular disease	26
hla types	26
mice infected	26
cov infection	26
intracellular cytokine	26
seroconversion panels	26
bronchoalveolar lavage	26
immune regulation	26
years overall	26
new automated	26
two consecutive	26
lung function	26
protein sequence	26
epitopes using	26
using spss	26
mg daily	26
antigenic peptide	26
bd biosciences	26
liver function	26
severe neutropenia	26
molecules per	26
venous catheter	26
studies using	26
pandemic influenza	26
disease susceptibility	26
potential donors	26
protein levels	26
early relapse	26
dose melphalan	26
gag retention	26
identify patients	26
weeks gestation	26
treatment strategies	26
might also	26
many cases	26
igg subclass	26
whereas patients	26
cell cultures	26
within weeks	26
protein kinase	26
abo group	26
two methods	26
medical treatment	26
cell doses	26
side chain	25
clinical conditions	25
maternal plasma	25
multiple hla	25
exclusion criteria	25
end point	25
tbi gy	25
gamma irradiation	25
cytokine profile	25
binding protein	25
therapeutic strategy	25
core protein	25
marrow derived	25
better outcome	25
linked immunosorbent	25
quantitative real	25
severe adverse	25
ecp treatment	25
autologous donors	25
high binding	25
using anti	25
dna sequencing	25
heavily pretreated	25
biopsy specimens	25
cd depletion	25
general practitioners	25
tract infections	25
patients years	25
years period	25
genetic variants	25
increasing number	25
different methods	25
cell transfusions	25
least three	25
patients following	25
institutional review	25
therapeutic options	25
control cells	25
medical history	25
gene mutations	25
cell lysis	25
lps stimulation	25
cardiac allografts	25
compatible platelets	25
epitopes may	25
complete resolution	25
predicted epitope	25
density gradient	25
severe complication	25
chemotherapy alone	25
corticosteroid therapy	25
recombinant protein	25
undergoing allo	25
cell transplants	25
mouse strains	25
cd antigen	25
cmv igg	25
natural history	25
individual patient	25
nod scid	25
much lower	25
influenza infection	25
hematological recovery	25
mediated cytotoxicity	25
male donor	25
considered significant	25
marrow donor	25
th percentile	25
specific antigen	25
cytometry using	25
chart review	25
evaluable patients	25
gel cards	25
kidney disease	25
autologous hct	25
genetic diversity	25
following transfusion	25
gene transfer	25
standard therapy	25
exchange transfusion	25
patients infected	25
chronic allograft	25
cells isolated	25
identical donor	25
severe agvhd	25
recently described	25
obliterative bronchiolitis	25
large amounts	25
upper respiratory	25
plasmodium falciparum	25
significant effect	25
erythema multiforme	25
caucasian population	25
lung tissue	25
using cd	25
molecular remission	25
vaccine constructs	25
immunosorbent assay	25
inflammatory processes	25
primary immune	25
alternative donors	25
artificial neural	25
volunteer donors	25
langerhans cells	25
donor pool	25
steroid treatment	25
transfusion centers	25
apheresis donors	25
will lead	25
available data	25
reduced toxicity	25
active celiac	25
platelet content	25
ii clinical	25
every weeks	25
delayed hemolytic	25
longer time	25
hyperacute rejection	25
urgent need	25
analysed using	25
spike peptide	25
donor transplant	25
causative agent	25
restricted epitope	25
increased cd	25
becton dickinson	25
closed system	25
adherent cells	25
oxidative stress	25
alkaline phosphatase	25
health sciences	25
way anova	24
first month	24
two children	24
predictive factors	24
molecular testing	24
remains unknown	24
systemic sclerosis	24
allogenic hematopoietic	24
much higher	24
organ damage	24
significant morbidity	24
transfusion process	24
national haemovigilance	24
without compromising	24
significantly elevated	24
method using	24
several years	24
ctl activity	24
murine model	24
epitope predictions	24
cells expressed	24
hla antibody	24
first study	24
analytical sensitivity	24
epitopes identified	24
abo incompatible	24
fi eld	24
cell help	24
pooled platelet	24
second patient	24
ultrio assay	24
murine models	24
protein structures	24