bigram

This is a table of type bigram and their frequencies. Use it to search & browse the list to learn more about your study carrel.

bigram frequency
golgi apparatus763
plasma membrane590
endoplasmic reticulum507
golgi complex484
cell surface430
secretory pathway410
membrane proteins349
golgi network291
membrane protein279
amino acid246
amino acids218
secretory proteins218
infected cells211
golgi membranes203
transmembrane domain186
cytoplasmic domain183
golgi cisternae152
golgi localization151
secretory granules144
cytoplasmic tail141
linked oligosaccharides139
golgi stack138
newly synthesized133
mouse hepatitis131
golgi retention130
hepatitis virus123
intermediate compartment121
golgi transport120
membrane traffic113
mammalian cells112
golgi compartment111
golgi membrane109
hela cells108
epithelial cells106
integral membrane105
golgi stacks102
vesicular stomatitis101
vaccinia virus100
sialic acid99
intracellular transport98
protein transport97
coated vesicles95
fusion proteins91
stomatitis virus90
spanning domain89
guanine nucleotide89
rna replication89
nucleotide exchange88
mdck cells88
viral proteins87
lysosomal enzymes86
transport vesicles85
cells expressing84
golgi compartments84
regulated secretory83
virus replication83
electron microscopy83
linked oligosaccharide83
protein sorting82
treated cells81
viral replication80
cell types80
vesicular transport79
fusion protein79
type i78
cells infected78
sorting signals77
saccharomyces cerevisiae76
man ii75
influenza virus74
golgi enzymes73
host cell73
type ii73
herpes simplex73
retention signal72
golgi proteins72
mannose residues71
ribosylation factor71
transmembrane domains70
secretory granule69
mannosidase ii69
rat liver69
simplex virus69
golgi structure68
er membrane68
binding protein68
cell line68
golgi intermediate67
table i67
secretory vesicles66
doc id65
cord uid65
structural proteins65
arf gefs64
vesicle formation63
ribophorin i63
viral rna62
rough endoplasmic62
respiratory syndrome62
may also62
acid residues61
golgi region61
secretory protein61
surface expression61
gene product61
arf proteins60
lumenal domain60
acute respiratory59
replication complex59
severe acute57
indirect immunofluorescence57
cos cells57
golgi fragmentation57
er proteins57
lipid bilayer57
cell lines55
exchange factor55
membrane fusion55
att cells55
golgi ribbon54
class i54
molecular weight54
bfa treatment54
retrograde transport54
man glcnac53
virus assembly53
envelope protein53
mg ml53
early secretory52
trans golgi52
golgi protein52
forest virus52
animal cells51
protein kinase51
semliki forest50
binding proteins50
exchange factors50
mm tris50
transmembrane proteins50
budding compartment50
elementary unit50
golgl apparatus50
oligosaccharide chains49
highly conserved49
complex formation48
resident proteins48
growth factor48
membrane vesicles48
gbf gea48
monoclonal antibody48
rna viruses48
endocytic pathway47
protein synthesis47
transfected cells46
polarized epithelial46
yeast golgi46
class ii46
signal peptide46
described previously46
transmembrane region46
cell biology46
glucosidase i46
linked glycosylation45
rough er45
vacuolar membrane45
african swine45
cell type45
swine fever45
coat proteins45
late golgi45
chimeric proteins44
cytoplasmic domains44
membrane association44
mm caffeine44
syndrome coronavirus44
big sec44
cell culture43
chimeric protein43
replication complexes43
membrane glycoproteins43
takes place43
glycoprotein processing43
spike protein43
sorting signal43
determine whether42
vesicle budding42
targeting signal42
signal sequence42
fever virus42
cis golgi42
viral glycoproteins42
terminal domain41
infectious bronchitis41
viral tubes41
acid sequence41
protein interactions41
two distinct41
protein secretion41
progeny virions41
glc man40
bronchitis virus40
viral envelope40
hybrid proteins40
oligosaccharide chain40
medial golgi40
murine coronavirus40
sialic acids39
mannosidase i39
control cells39
nuclear envelope39
membrane trafficking39
immunofluorescence microscopy39
epithelial cell38
quality control38
molecular mass38
mhv infection38
replication sites38
dna replication38
results suggest38
transition vesicles37
wild type37
viral dna37
ion channel37
signal peptidase37
exocytic pathway37
export complexes36
crystal structure36
leu leu36
proteins may36
living cells36
sec ml36
er buds36
er retention36
tr chimeras35
high mannose35
room temperature35
eukaryotic cells35
rna polymerase35
cell fusion35
activator protein35
ganglioside gm34
envelope proteins34
virus particles34
mouth disease34
catalytic domain34
goat anti34
viral membrane34
similar results34
gold particles34
mhv replication34
mhc class34
copi coats34
membrane glycoprotein34
coronavirus spike34
virus infection34
electron microscope34
golgi matrix33
two proteins33
viral genome33
er stress33
binding sites33
virus factories33
cell adhesion33
alkaline phosphatase33
soluble proteins33
immature vesicles33
env gene33
golgi trafficking33
endothelial cells33
cell cycle32
three times32
cultured cells32
disease virus32
staining pattern32
enveloped viruses32
proteolytic processing32
even though32
gene expression32
cytosolic domain32
intact cells32
glucosidase ii32
cell periphery32
golgi vesicles31
virus type31
kidney cells31
mutant cells31
protein trafficking31
host cells31
important role31
arf family30
cells treated30
structural protein30
liquid crystalline30
viral protein30
genomic rna30
amino terminus30
subcellular localization30
monoclonal antibodies30
transferrin receptor30
cargo proteins30
sars coronavirus30
lipid rafts29
arf activation29
transmembrane segment29
copi vesicles29
i molecules29
high levels29
previously described29
recent studies29
viral particles29
early golgi29
nervous system29
time point29
immunoelectron microscopy29
exit sites29
min chase29
phosphate receptor29
sequence similarity29
cellular membranes29
carboxy terminus28
proteins involved28
retention signals28
protein complex28
lipid composition28
lysosomal membrane28
gtp binding28
coronavirus envelope28
intracellular localization28
stranded rna28
bound form28
stem region28
lipid bilayers28
protein ic28
per cell27
late endosomes27
vacuolar protein27
membrane associated27
type tr27
sec domain27
reduced temperature27
fatty acyl27
wpb size27
membrane spanning27
constitutive secretory27
coat protein27
gene products27
cytoplasmic face27
viral infection27
immune response27
also known27
secretory vesicle27
replicase proteins27
open reading26
rab proteins26
linked glycans26
rat hepatocytes26
terminal region26
nucleocapsid protein26
conjugated goat26
review see26
viral glycoprotein26
yeast cells26
anchored proteins26
virus glycoprotein26
membrane domains26
ergic golgi26
nonstructural protein26
transmissible gastroenteritis26
serial sections26
table ii26
immature secretory26
localization signals26
ic elements26
retention mechanism26
kda protein25
final concentration25
pc cells25
ganglioside biosynthesis25
virus hemagglutinin25
regulated pathway25
protein targeting25
golgi glycosyltransferases25
subcellular fractionation25
linked mannose25
kd protein25
lysosomal enzyme25
hydrophobic thickness25
life cycle25
killer toxin25
terminal amino25
coronavirus replication25
small gtpase25
take place25
avian coronavirus25
sorting machinery25
bulk flow25
st gal25
vps mutant25
basolateral sorting25
rna synthesis25
bag cell25
mm edta24
secreted proteins24
synthesized proteins24
rabbit anti24
ph domain24
family proteins24
luminal domain24
cisternal maturation24
tissue culture24
envelope glycoproteins24
hydrophobic domain24
cell cultures24
conformational change24
arf gef24
intracellular membranes24
directed mutagenesis24
may play24
copi coat24
results indicate24
polarized cells24
protein complexes24
associated protein24
spanning domains24
membrane transport24
protein folding24
different cell24
yeast vacuolar24
binding site24
fatty acid23
low levels23
kd form23
cell biol23
carboxyesterase sec23
ras wt23
plasma membranes23
transitional elements23
coronavirus mhv23
sucrose gradients23
cellular proteins23
hybrid protein23
i astrocytes23
residue sequence23
membrane anchor23
cell death23
membrane dynamics23
cells incubated23
dependent manner23
thin sections23
ribosylation factors23
acid phosphatase23
protein associated23
breast cancer23
er exit23
cell lysates23
targeting signals23
dcg proteins23
transmembrane protein23
default pathway22
terminal signal22
reading frame22
human disease22
envelope glycoprotein22
factor receptor22
cytoplasmic tails22
linked glycoproteins22
two different22
ras proteins22
protein may22
transmembrane ot22
arf protein22
lr cells22
positive cells22
packaging signal22
secretory pathways22
culture medium22
copii vesicles22
taken together22
linked sugars22
medium containing22
cleavage site22
enzymatic activity22
golgi mannosidase22
heavy chain22
nlrp inflammasome22
von willebrand22
peripheral membrane21
strand rna21
protein glycosylation21
transcription factor21
yeast secretory21
vitro translation21
previous studies21
intracellular membrane21
adaptor protein21
ii membrane21
proteins destined21
luminal er21
invariant chain21
rca agarose21
like protein21
membrane rearrangements21
sucrose gradient21
molecular cloning21
fatty acids21
infected cell21
dense core21
golgi targeting21
liver golgi21
er membranes21
mediated endocytosis21
essential role21
polyacrylamide gels21
condensed secretory21
posttranslational modifications21
one possibility20
time points20
signal transduction20
punctate structures20
biol doi20
free medium20
previously shown20
mitotic golgi20
least one20
proteins accumulate20
apical membrane20
kindly provided20
gm activator20
constitutive pathway20
cell division20
reporter protein20
cona sepharose20
golgi function20
bhk cells20
assembly sites20
unpublished data20
membrane topology20
electron microscopic20
disulfide bonds20
sorting receptor20
proteins within20
cells using20
also found20
conformational changes20
basolateral surface20
molecular dynamics20
localization signal20
density lipoprotein20
endocytic compartment20
host immune20
matrix protein19
phosphatidic acid19
polyclonal antibodies19
willebrand factor19
uninfected cells19
family members19
processing enzymes19
proteins containing19
small gtpases19
poliovirus replication19
wt vol19
actin cytoskeleton19
hydrophobic length19
bag cells19
ii cytoplasmic19
glycoprotein biosynthesis19
acetylglucosaminyltransferase i19
cell wall19
also observed19
gtp hydrolysis19
membrane structures19
pro teins19
virus strain19
gene encoding19
capsid protein19
sindbis virus19
arf gap19
washed three19
structural features19
condensing secretory19
oligosaccharide processing19
legionella pneumophila19
progeny particles19
glycosyltransferase complexes19
glcnac transferase19
matrix proteins19
total number19
arf gaps19
ion channels19
acyl chains19
epithelial polarity19
pbs containing19
large number19
vesicular traffic18
nh terminus18
escherichia coli18
enzymes involved18
coronavirus mouse18
membrane compartments18
also involved18
cell proliferation18
molecular mechanisms18
golgi elements18
cells grown18
along microtubules18
synaptic vesicle18
ribbon formation18
rat brain18
mutational analysis18
see materials18
cells showed18
luciferase expression18
also showed18
golgi marker18
nan sha18
oligomer formation18
small immature18
cho cells18
posttranslational modification18
contains two18
bovine coronavirus18
low ph18
extracellular matrix18
single transmembrane18
may occur18
permeabilized cells18
recent study18
regulated secretion18
catalytic domains18
er protein18
derived vesicles18
signal anchor18
data indicate18
membrane surface18
targeting information18
gastroenteritis coronavirus18
surface area18
kdel receptor18
virus glycoproteins18
structural basis18
unfolded protein17
organelle structure17
spike glycoprotein17
peptidase cleavage17
van der17
aromatic residues17
unpublished results17
mass spectrometry17
coronavirus assembly17
ic activity17
protein interaction17
speci city17
biosynthetic protein17
basolateral membrane17
secondary antibody17
specific antibodies17
wide range17
low density17
er extract17
recent evidence17
outer chain17
heparan sulfate17
glucose residues17
nuclear membrane17
virus maturation17
cov infection17
least three17
based sorting17
er export17
western blotting17
potent inhibitor17
carbohydrate structures17
vesicular trafficking17
coronavirus infection17
basolateral targeting17
high molecular17
chondroitin sulfate17
see section17
ii transmembrane17
golgi markers17
min pulse17
hybrid molecules17
close proximity17
containing vesicles17
host proteins17
gtpase activity17
lysosomal storage17
cell extracts17
critical role17
lipoprotein receptor17
glycosylation site17
mutant proteins17
virus membrane17
lysosomal proteins17
early endosome17
resident golgi17
budding profiles16
gm gangliosidosis16
rsv env16
coated pits16
closely related16
retrieval signal16
membrane lipids16
protein translocation16
tgn membrane16
external domain16
regulated exocytosis16
golgi traffic16
functional analysis16
arf gtpase16
many cases16
sequence homology16
hepatitis coronavirus16
pancreatic acinar16
uranyl acetate16
granule formation16
ribophorin ii16
nucleotide sequence16
rab gtpases16
cystic fibrosis16
lysine motif16
snare proteins16
associated proteins16
negatively charged16
present study16
see also16
golgi interface16
di erent16
multidrug resistance16
rich region16
recycling pathway16
membrane lipid16
first amino16
galactose oxidase16
containing mm16
two types16
protein response16
state distribution16
virus budding16
anterograde traffic16
translocation across16
virus rna16
vacuolar targeting16
nan title16
activating protein16
cell migration16
wheat germ16
restrictive temperature16
deletion mutants16
terminal residues16
may provide16
first step16
oligosaccharide structure16
lipid droplets16
secondary antibodies16
dna polymerase16
buds per15
also contain15
modifying enzymes15
snare complex15
carbohydrate structure15
hamster kidney15
cell growth15
sachs disease15
hydrophobic mismatch15
sarcoma virus15
primary structure15
uukuniemi virus15
early endosomes15
storage diseases15
surface staining15
functional role15
constitutive secretion15
epidermal growth15
data suggest15
injected intravitreally15
canine kidney15
different types15
acid residue15
protein forms15
ldl receptor15
cytoplasmic side15
rous sarcoma15
gene encodes15
ot helices15
endocytic recycling15
terminal cytoplasmic15
clear vesicles15
apical sorting15
induced apoptosis15
studies indicate15
sseg mutant15
protein aggregates15
type inclusions15
dense bodies15
tumor cells15
mannose oligosaccharides15
capsid proteins15
mutant forms15
insulin receptor15
rod outer15
proteolytic cleavage15
active site15
residues within15
cancer cells15
sec proteins15
gene therapy15
naturally occurring15
recycling endosomes15
adaptor complex15
positively charged15
er resident15
proteins also15
short cytoplasmic15
small vesicles15
bombyx mori15
acid sequences15
substrate specificity15
galactose residues15
may function15
manuscript submitted15
protein aggregation15
membrane curvature15
amphipathic helix15
polyhydroxy alkaloids15
subcellular location15
coated vesicle15
large immature15
give rise15
factor gbf15
different mechanisms15
transfer protein15
viral components15
core protein15
side chains15
membrane binding15
yeast tgn14
transport pathway14
coding region14
kin recognition14
vesicles containing14
membrane compartment14
sorting information14
pulse labeled14
striated muscle14
sec gtd14
channel activity14
bilayer thickness14
er compartment14
el protein14
endosomal membrane14
kex gene14
distributed throughout14
acyl chain14
coat complexes14
vesicular egress14
small amount14
baby hamster14
darby canine14
recombinant protein14
hepatoma cells14
perinuclear region14
central nervous14
phosphate receptors14
iicr chimera14
cdna encoding14
neuroendocrine cells14
small gtp14
inhibited guanine14
intracellular distribution14
effector proteins14
binding constants14
cellular autophagy14
mature virions14
chimeric cdnas14
virus release14
brain gangliosides14
dipeptidyl aminopeptidase14
transport carriers14
table iii14
also present14
coronavirus el14
granule membrane14
autophagic vacuoles14
anchor sequence14
membrane domain14
endocrine cells14
protein localization14
nonstructural proteins14
neuraminic acid14
positive feedback14
syncytia formation14
higher order14
exit site14
prototype serum14
biosynthetic pathway14
class iii14
hydrophobic residues14
secreted protein14
inhibitory activity14
cell lysis14
expression vector14
marker proteins14
cell sections14
virus factory14
possible role14
molecular biology14
apical surface14
glycosylation sites14
cell surfaces14
much less14
hydrophobic amino14
arf guanine14
sugar chains14
may represent14
soluble er14
tubular elements14
astrocytic processes14
resistant oligomer14
cellular protein14
membrane permeability14
antibodies specific14
detected using14
linked carbohydrate14
associated membrane13
ii arfs13
golgi vacuoles13
mediated golgi13
free system13
medial cisternae13
cellular components13
recombinant proteins13
en route13
terminal intermediate13
isolation membrane13
series gangliosides13
membrane traycking13
seems likely13
crystalline phase13
germ agglutinin13
membrane recruitment13
accessory proteins13
nascent secretory13
protein also13
anchor domain13
distinct compartments13
golgi residents13
per se13
chain length13
buffer containing13
chase period13
dna damage13
poliovirus rna13
sphingolipid synthesis13
direct interaction13
retention motif13
transmembrane anchor13
like structures13
terminal glycosylation13
dictyostelium discoideum13
studies showed13
point mutations13
like particles13
also shown13
cytohesin arno13
mutant protein13
virus envelope13
texas red13
ph domains13
enzyme activity13
nonpermissive temperature13
trp residues13
mannosidase inhibitors13
contained within13
surface proteins13
poliovirus infection13
protein ion13
polar residues13
rab gtpase13
coronavirus rna13
labeled cells13
acidic compartments13
processing events13
rabbit antiserum13
gives rise13
specify golgi13
agarose columns13
cholera toxin13
cells transfected13
resistance protein13
intracellular replication13
endosomal compartments13
human diseases13
proteolytically processed13
replication compartments13
revised form13
large arf13
structural maturation13
protein containing13
rabbit igg13
type cells13
protein exit13
dna fragment13
oligosaccharide structures13
cell membrane13
rabbit serum13
luminal domains13
sequences within13
washed twice13
golgi lumen13
high level13
mm hepes13
sequence analysis13
cell recognition13
viral assembly13
lipid molecules13
acinar cells13
sample buffer13
family member13
vesicle trafficking13
human cells13
flanking sequences13
endosomal system13
viral particle13
direct evidence13
rapidly degraded13
ot helix13
resident protein13
ii molecules13
primary antibodies13
terminal sugar13
cis side13
enzyme complexes12
ser ser12
rab effector12
sfv glycoproteins12
headgroup region12
intracellular organelles12
murine hepatitis12
may involve12
transition vesicle12
hydroxyl groups12
exclusion zone12
copii vesicle12
el glycoprotein12
genome replication12
cargo molecules12
major histocompatibility12
er lumen12
using anti12
golgi exclusion12
membrane receptors12
golgi stacking12
molar ratio12
like activity12
glucose starvation12
processing glucosidases12
membrane tethering12
protein required12
outer segments12
active sites12
chemical co12
affinity chromatography12
transmission electron12
hr postinfection12
may vary12
coa reductase12
tubular structures12
ul gene12
human brain12
virus nonstructural12
form complexes12
remains unclear12
maturation model12
progeny virus12
pc jr12
fluorescence microscopy12
hydrophobic transmembrane12
processing inhibitors12
charged amino12
hamster ovary12
metabolic labeling12
major role12
see table12
plant cells12
test whether12
golgi staining12
isg budding12
protein composition12
tgn membranes12
pancreatic exocrine12
direct role12
gel electrophoresis12
motor proteins12
secretory organelles12
sandhoff disease12
static retention12
electrophoretic mobility12
expression levels12
partially purified12
stacked cisternae12
golgi reassembly12
structure formation12
truncated ribophorin12
rabbit antibodies12
average number12
griscelli syndrome12
target cells12
also inhibited12
membrane fractions12
nuclear inclusions12
terminal amphipathic12
primary sequence12
coronavirus infectious12
allowed us12
expressed alone12
apparatus cisternae12
free dme12
chinese hamster12
mannose type12
also occurs12
er mannosidase12
histocompatibility complex12
neu gc12
secondary structure12
golgi morphology12
binding domain12
early times12
residue transmembrane12
gef activity12
immunodeficiency virus12
results obtained12
virus proteins12
golgi components12
perinuclear localization12
transport vesicle12
correct golgi12
binding constant12
smooth er12
er markers12
leucine zipper12
human immunodeficiency12
muscle cells12
different membrane11
membrane recycling11
polarized sorting11
intermediate filaments11
also occur11
silk fibroin11
well known11
vesicular carriers11
proteins associated11
protein encoded11
ca concentration11
resident er11
dcg protein11
also detected11
disulfide bond11
cell section11
alp fusion11
membrane vesicle11
also called11
cultured rat11
sugar residues11
surface protein11
golgi fragments11
glycan synthesis11
truncated forms11
intermediate form11
terminal transmembrane11
enriched fraction11
ribophorins i11
immune complexes11
art cells11
fxfxd motif11
dcg synthesis11
surface receptors11
cell fractionation11
polyclonal antibody11
apparatus clsternae11
newly made11
chorionic gonadotropin11
sigma chemical11
mediated arf11
exchange protein11
molecular interactions11
crucial role11
phosphate buffer11
multivesicular bodies11
first site11
major capsid11
marker protein11
found within11
mouse igg11
immunocytochemical localization11
phase transition11
mhv rna11
within cells11
studies suggest11
new england11
reporter gene11
results demonstrate11
may serve11
polyclonal anti11
coronavirus particles11
granule biogenesis11
glcnac structures11
tubular network11
ultrastructural analysis11
least two11
transfer proteins11
golgi biogenesis11
frog virus11
bfa effect11
cytoplasmic tall11
pathway may11
homotypic fusion11
eukaryotic supergroups11
activated protein11
cd hybrid11
linked glucose11
golgi intermediates11
many proteins11
ii astrocytes11
two major11
central role11
transferase i11
higher levels11
signal recognition11
yeast saccharomyces11
mice lacking11
protein structure11
mannosyltransferase activity11
cop i11
polypeptide chain11
virus dna11
dna synthesis11
terminal domains11
exocrine cells11
poorly understood11
human cytomegalovirus11
er surface11
trans cisternae11
consensus motif11
subcellular distribution11
immunological synapse11
gly leu11
transitional endoplasmic11
host membrane11
actin filaments11
related proteins11
might also11
targeting motif11
intracellular trafficking11
live cells11
specific membrane11
jack bean11
immune system11
gm synthase11
neuronal cells11
coil proteins11
forward transport11
chase experiments11
type iii11
reticulum membrane11
liver slices11
linked saccharides11
pathogenicity island11
charged residues11
human chorionic11
transport step11
calf serum11
carbohydrate chains11
microscopic studies11
using antibodies11
specific protein11
different proteins11
also inhibits11
processing pathway11
lower molecular11
complex oligosaccharides11
intracellular protein11
sars cov11
secretory cells11
tumor cell11
cathd ml11
deletion mutant11
membrane targeting11
vacuolar proteases11
terminal half11
large vesicles11
copi vesicle11
rna interference11
complex type11
morphological changes11
eukaryotic cell10
membrane composition10
surface glycoproteins10
eastman kodak10
low temperature10
early stages10
transforming activity10
gm gangliosidoses10
biological membranes10
untreated cells10
storage disease10
protein contains10
lysosomal sorting10
single amino10
core vesicles10
intracellular compartments10
gtp exchange10
evidence suggests10
national institutes10
terminal hydrophobic10
chimeric constructs10
viral factories10
fibrosis transmembrane10
fixed cells10
clathrin coats10
resistant form10
leu val10
glycosidase inhibitors10
one another10
firefly luciferase10
later stages10
tegument proteins10
cell receptor10
endocytic compartments10
progeny coronavirus10
potential role10
purified rhodopsin10
golgi cisterna10
gap activity10
lectin affinity10
media containing10
two models10
protein sequence10
highly expressed10
coronavirus replicase10
results show10
soluble protein10
golgi disassembly10
transport routes10
influenza hemagglutinin10
human serum10
may facilitate10
expression system10
receptor molecules10
novel golgi10
cultured human10
lysosomal targeting10
mannosidase inhibitor10
little effect10
average diameter10
rapid redistribution10
cells containing10
vesicles may10
human coronavirus10
membranespanning domain10
best characterized10
first transmembrane10
mosaic virus10
cells also10
may interact10
intestinal epithelial10
plasmid dna10
poliovirus proteins10
translational modifications10
terminal sialic10
mouse models10
virus gene10
affinity purified10
golgi enzyme10
i transmembrane10
important roles10
dppiv cdna10
specific interaction10
cells may10
gal promoter10
cvt pathway10
cell walls10
interacting protein10
membrane source10
unglycosylated form10
cell organelles10
golgi subcompartment10
antibody specific10
lumenal domains10
golgi subcompartments10
i membrane10
cytoplasmic sequences10
mm mgcl10
protein traffic10
keratan sulfate10
vesicle fusion10
confocal microscopy10
unclear whether10
arf exchange10
additional studies10
components involved10
prohormone processing10
growth hormone10
cytoplasmic signal10
intact ribophorin10
stem domain10
vacuolar proteins10
polymerase ii10
sugar transferases10
linked saccharide10
three domains10
golgi localized10
xenopus oocytes10
genes encoding10
highly dynamic10
membrane cycling10
synthesized membrane10
final destination10
may explain10
culture supernatants10
hydrophobic region10
copii coats10
target membrane10
one side10
enzymatically active10
signalling pathways10
oligosaccha rides10
initial cleavage10
protein retention10
vacuoles operate10
consecutive sections10
group coronaviruses10
membrane anchorage10
stacking gel10
protein sequences10
unpublished observations10
coding sequence10
blood group10
immunoprecipitated using10
vesicle docking10
extracellular domain10
signal sequences10
cytosolic tail10
host cellular10
transiently transfected10
selective inhibition10
membrane bound10
chimeric cdna10
recombinant dna10
golgi boundary10
chlamydia trachomatis10
vesicles called10
bfa inhibits10
membrane structure10
pancreatic cells10
core structure10
steady state10
corona virus10
membrane components10
psg cells10
arf recruits10
high degree10
may reflect10
dna sequencing10
specific lipid10
mm nacl10
carrier vesicles10
technical assistance10
recombinant vaccinia10
observations suggest10
containing vacuoles10
sorting events10
sialyltransferase specify10
point mutation10
mm sodium10
densely packed10
linear density10
detergent solution10
nrk cells10
stress response10
ri molecules10
factory formation10
kinase ii10
export complex10
many different10
inclusion bodies10
glycosylation enzymes10
glycoprotein synthesis10
bunyamwera virus10
coated vesicular10
indicated times10
arl proteins10
fractions containing10
fluorescence quenching10
vero cells10
wga binding10
one face10
spike proteins10
immature dcvs10
intracellular sorting10
organizing center10
golgi structural10
neutralizing antibodies9
host factors9
indolizidine alkaloid9
hydrophobic matching9
mutant viruses9
aldrich syndrome9
synthesized viral9
asked whether9
targeting pathway9
lesser extent9
cardiac glycosides9
dendritic cells9
prevents secretion9
syndrome patients9
large oligomer9
side chain9
signal peptides9
ultrastructural level9
rat kidney9
sensitive mutants9
purified anti9
closely associated9
early studies9
vesicles budding9
kda form9
structural organization9
secretory glycoproteins9
sirnas targeting9
mannose residue9
mature virus9
late stage9
posttranslational processing9
drug development9
transport route9
dependent retrograde9
coated buds9
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ceramide accumulation9
tertiary structure9
active arf9
functionally relevant9
hmg coa9
sodium carbonate9
intermediate filament9
glucosidase inhibitors9
axonal transport9
pv particles9
inflammasome activation9
motor protein9
lipid droplet9
structures may9
will also9
conductance regulator9
translation product9
lumenal proteins9
tg ml9
intracellular retention9
enzymes responsible9
viral membranes9
intracellular targeting9
transmembrane helices9
bone marrow9
viral propagation9
cytohesin gefs9
containing either9
cellular machinery9
vacuole targeting9
intermediate elements9
palmitic acid9
translocation apparatus9
vesicle targeting9
basic amino9
three proteins9
several studies9
rough surface9
limiting membrane9
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new insights9
ovary cells9
adp ribosylation9
signal prevents9
tyr residues9
pfu cell9
mechanisms involved9
low molecular9
known whether9
major site9
defective mutants9
anterior pituitary9
activating proteins9
infection induces9
rubella virus9
expression vectors9
relocated golgi9
bound state9
catalytic sec9
may contribute9
sorting within9
vesicle tethering9
carbohydrate binding9
protein involved9
cells harboring9
membrane insertion9
host membranes9
ring structure9
leukemia virus9
specifies trans9
threonine residues9
virus replicase9
kind gift9
gibco brl9
replication occurs9
regulatory protein9
proteins might9
constitutive exocytic9
synthesized chemically9
conjugated secondary9
basolateral domains9
boundary lipids9
golgi dispersal9
cerebral cortex9
golgi system9
cysteine residues9
blunt ended9
endoproteolytic cleavage9
elh prohormone9
also binds9
terminal portion9
mediated apoptosis9
protein interacts9
glass coverslips9
immunofluorescence using9
membrane anchoring9
via interaction9
protein expressed9
tetrahymena thermophila9
density gradient9
cellular function9
basolateral plasma9
er recycling9
outer segment9
dna viruses9
life technologies9
myosin va9
vp protein9
section ii9
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golgi organization9
reverse genetics9
critical reading9
er plus9
hds domain9
transmembrane conductance9
kbp bamhi9
scv membrane9
type dpap9
amersham corp9
nuclear localization9
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biological function9
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network localization9
particular protein9
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plasma vwf9
membrane trayc9
dimensional structure9
plus golgi9
compare lanes9
nd bodies9
cruz biotechnologies9
gaussia luciferase9
two membrane9
cef expressing9
intracellular location9
protein oligomerization9
well characterized9
proper localization9
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mung bean9
observations indicate9
human tr9
three glucose9
normal breed9
immunogold labelling9
membered ring9
protein function9
core oligosaccharide9
melanoma cells9
autosomal recessive9
studies demonstrated9
osmium tetroxide9
viral structural9
granule proteins9
default compartment9
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boehringer mannheim9
intracellular mature9
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virion assembly9
animal cell9
clathrin adaptor9
vacuolar localization9
efficient sorting9
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sepharose beads9
structural characterization9
viral inclusions9
bovine rhodopsin9
mannose units9
trafficking pathways9
salmonella pathogenicity9
protein binds9
bean seedlings9
clathrin coated9
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gradient centrifugation9
small number9
pituitary tumor8
protein export8
hyaluronic acid8
also requires8
vol vol8
vesicles associated8
hydrocarbon core8
mutations affecting8
resistant oligomers8
sodium borohydride8
proteins appear8
progeny pv8
cellular secretory8
lipid membrane8
syndrome protein8
may result8
periventricular heterotopia8
dipeptidyl peptidase8
presumably due8
pulse plus8
two independent8
conserved among8
animal viruses8
extracellular space8
microtubule motor8
cell membranes8
lipid components8
regulated exocytic8
mr kkk8
puri ed8
membranes via8
dependent kinase8
constitutively secreted8
dependent rna8
pro tein8
sds resistance8
muscular dystrophy8
gtpase rab8
genetically engineered8
assembly process8
substrate arf8
proteins required8
complex requires8
asparagine residues8
mixed extracts8
limited number8
widely used8
two bands8
pudlak syndrome8
actin dynamics8
also required8
early stage8
novel coronavirus8
precursor protein8
tubular clusters8
cdnas encoding8
two enzymes8
endocytic pathways8
cleavage sites8
located within8
one cisterna8
lipid metabolism8
golgi movement8
particle formation8
findings suggest8
stem cells8
three distinct8
containing motif8
soluble secretory8
apparent molecular8
ga staining8
polarized cell8
protein quality8
experiments showed8
second signal8
transduction pathways8
specific receptors8
terminal side8
cargo receptor8
linked glycoprotein8
mammalian golgi8
associated virus8
monensin block8
protease inhibitor8
ribophorin molecules8
retrograde traffic8
trypanosoma brucei8
rbl cells8
linked oligosaccha8
virus genome8
acceptor golgi8
time retinas8
von heijne8
may form8
late ic8
first time8
particles per8
retrieval mechanism8
ionic strength8
individual proteins8
sucrose density8
terminal regions8
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electron micrographs8
bacterial replication8
cancer cell8
high ph8
experimental evidence8
ubiquitin ligase8
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probably due8
gel phase8
host range8
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bound forms8
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rain pulse8
exocrine pancreatic8
two golgi8
immunofluorescence staining8
yeast kex8
cellular membrane8
boundary lipid8
light chain8
tethering protein8
clathrin heavy8
gel filtration8
rabbit antisera8
complex types8
sorting receptors8
perinuclearly located8
membrane origin8
transitional element8
biotechnologies sc8
permissive temperature8
labeled proteins8
concentration gradient8
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vesicle transport8
gave rise8
ii activity8
protein requires8
dna sequence8
lipid modifications8
vsv antibody8
cultured animal8
mhv serum8
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activity towards8
pig liver8
enveloped virus8
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isolated tubes8
future studies8
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glycosphingolipid synthesis8
functionally distinct8
cellular factors8
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clear whether8
mm cac8
distinct functions8
structures containing8
biological functions8
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human fibroblasts8
ras derivatives8
total er8
transgenic lines8
late endosome8
mutually exclusive8
structural studies8
vitro studies8
small interfering8
proteins contain8
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fetal calf8
consensus sequence8
protein assembly8
functional interface8
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gene required8
interact directly8
different stages8
may depend8
immune responses8
bc protein8
proteins associate8
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secre tory8
retrograde movement8
data presented8
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poliovirus protein8
acid long8
casein kinase8
related protein8
reporter molecules8
mature forms8
trans side8
metabolically labeled8
encephalomyocarditis virus8
limiting step8
acidic residues8
counting method8
therapeutic intervention8
infectious virus8
complex chains8
rabbit polyclonal8
intracellular movement8
ss methionine8
labeled tf8
signi cant8
mm na8
hindlii sites8
soluble forms8
activity may8
cell polarity8
structural components8
cellular pathways8
inhibi tors8
exocrine pancreas8
retained within8
expressing gml8
cellular response8
hydroxytryptamine receptor8
microscopy showed8
without affecting8
mm dishes8
ultrastructural studies8
cultured fibroblasts8
budding site8
immature virions8
specific functions8
molecular basis8
tubular extensions8
nagt i8
natural sources8
cellular origin8
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yeast vacuole8
thiamine pyrophosphatase8
transgenic line8
infected cultures8
vesicles present8
complex carbohydrates8
transport process8
complex localization8
retrieval motif8
reticulum retention8
gene family8
apical proteins8
surface transport8
endosomal membranes8
full length8
small amounts8
glutamic acid8
chimeric construct8
protein family8
primary cultures8
acidic ph8
primary antibody8
cis face8
atg proteins8
protein disulfide8
inhibitory properties8
vesicle coat8
immunoblot analysis8
interfering rnas8
elongation factor8
gef gbf8
specific binding8
protein correlates8
recombinant virus8
calcium ions8
photoreceptor cells8
tested whether8
golgi mixed8
terminal sequence8
arno cytohesin8
autophagosome formation8
ph optimum8
structural requirements8
erm family8
investigated whether8
rc formation8
multiple sequence8
sec subfamily8
sites within8
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arf gtpases8
hybrid structures8
knockout mice8
protein domains8
culture cells8
model membranes7
iicr li7
enzyme activities7
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western blot7
viral mrnas7
thank dr7
expressing either7
cd edna7
binding activity7
shuttle vesicles7
sec subfamilies7
amyotrophic lateral7
biosynthetic transport7
like vesicles7
mouse brain7
capsid assembly7
upper band7
mouse model7
like enzyme7
correct localization7
functional roles7
cytoplasmic surface7
sorting pathway7
stained cells7
within golgi7
mature granules7
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terminal galactose7
large numbers7
vacuolar hydrolases7
outer surface7
proteins lacking7
arlington heights7
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cytoplasmic structures7
planar projection7
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membraned vesicles7
prevacuolar compartment7
nm gold7
saturation buffer7
dense cores7
genetic approaches7
ic cis7
cellular localization7
may therefore7
now known7
free energy7
leukemia protein7
subcellular organization7
whole cell7
protein movement7
biological activity7
layer chromatography7
budding yeast7
stranded dna7
vacuolar membranes7
receptor tyrosine7
specific sorting7
secretory compartments7
mammalian cell7
viroporin activity7
dmem containing7
trans cisterna7
much smaller7
still unclear7
horseradish peroxidase7
infection cycle7
apical targeting7
domain contains7
mutations within7
membranes derived7
virus protein7
ypt rab7
secretion pathway7
chase medium7
carbohydrate residues7
deficient mice7
dipeptidylpeptidase iv7
using affinity7
golgi integrity7
possible explanation7
experiments using7
lipid synthesis7
adenovirus type7
virulence protein7
normal rat7
golgi tgn7
intracellular accumulation7
individual golgi7
restriction sites7
monkey kidney7
ciliary targeting7
interestingly enough7
human herpesvirus7
data show7
molecular dissection7
mm naci7
lysis buffer7
polyacrylamide gel7
mdck cell7
caspase cleavage7
avian infectious7
containing vacuole7
gm ganglioside7
membrane orientation7
carboxyl terminus7
slow secretion7
i arfs7
membrane organization7
immunoperoxidase labeling7
tyrosine kinase7
endosomal trafficking7
sec gene7
biological activities7
may help7
punctiform fluorescence7
stably expressed7
downstream effectors7
golgi resident7
cells coexpressing7
tyrosine kinases7
vascular endothelial7
viral entry7
antibodies directed7
labeling experiments7
bovine brain7
three amino7
transmembrane segments7
fragment containing7
originally identified7
distinct mechanisms7
fusion events7
subcellular organelles7
reticulum exit7
tris acetate7
biological systems7
cytoplasmically exposed7
serial thin7
acetylneuraminic acid7
yeast vps7
autophagosome biogenesis7
acceptor compartment7
yeast sec7
cdna clone7
kda fhx7
ultrathin frozen7
psg cell7
binding studies7
another study7
peptidase iv7
maturation process7
colloidal gold7
anionic phospholipid7
five times7
core structures7
outer membrane7
functional characterization7
virion budding7
processing inhibitor7
chase experiment7
rabbits immunized7
glycosylation pathway7
internalization signals7
must occur7
microscopy studies7
reaction product7
dcg cargo7
golgi sorting7
peripheral sites7
type strain7
electron tomography7
protein appeared7
low concentrations7
chain elongation7
small molecule7
specific activity7
exocytic vesicles7
xhol site7
egf receptor7
fractionation studies7
er cisternae7
glcnac transferases7
translation products7
molecular mechanism7
interacting proteins7
membrane fraction7
early endosomal7
serial section7
cell phenotype7
retrieval system7
coronavirus glycoprotein7
vitro veritas7
research council7
discoidin i7
head groups7
golgi complexes7
kex protease7
relatively large7
protein samples7
specific cell7
clinical trials7
also reported7
several viruses7
signalling pathway7
result suggests7
mediated sorting7
soluble form7
first identified7
acid glycoprotein7
stem regions7
weight gtp7
laying hormone7
mutant strain7
foster city7
dilated rims7
large aggregates7
different regions7
chapter will7
independent mannose7
galactosyltransferase specifies7
adenovirus infection7
virion dna7
small percentage7
random distribution7
studies indicated7
coat components7
occurs within7
contact sites7
immunoglobulin receptor7
protein grasp7
processing steps7
different golgi7
provide evidence7
kd proteins7
arg lys7
great interest7
sequences serve7
major structural7
condensing vacuoles7
induced retrograde7
surface via7
menkes disease7
cell imaging7
facs analysis7
fusion peptide7
acid composition7
family arf7
gml oligomer7
distal cisternae7
also seen7
type kre7
recognition particle7
second bud7
helper virus7
glycan portion7
new class7
golgi functions7
histone deacetylase7
molecular modeling7
structural gene7
bilayer normal7
subcellular compartments7
plant cell7
granule cargo7
propylene oxide7
plasma cells7
chase periods7
processing intermediates7
pharmacological classes7
recent work7
human transferrin7
molecular masses7
protein phosphorylation7
growth medium7
polyclonal antiserum7
contained galactose7
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i mm7
virus production7
induced structures7
cdna fragment7
human intestinal7
gastroenteritis virus7
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sec product7
neu ac7
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protein might7
culture dishes7
domain may7
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lateral sclerosis7
randomly distributed7
sfv ts7
regulated pathways7
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nucleotide sugar7
specific proteins7
mm cacl7
hydrogen bonds7
specific targeting7
structural similarity7
complex gangliosides7
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gea subfamily7
leader sequence7
endogenous golgi7
killing zone7
proteins localized7
default destination7
cell biological7
rotavirus vp7
transport steps7
st sequence7
gene transfer7
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krijnse locker7
one study7
transport intermediates7
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homology domains7
first membrane7
light microscopy7
tr constructs7
mental retardation7
recent advances7
single gene7
attachment protein7
lysosomal acid7
growth factors7
rer membrane7
cacodylate buffer7
cytoplasmic nh7
smooth muscle7
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san diego7
core oligosaccharides7
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iii secretion7
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acetate buffer7
transport within7
nerve terminals7
high resolution7
purified fhx7
pro cessing7
cytosolic proteins7
mutant cell7
exocytic pathways7
acid linker7
virus intracellular7
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viral titers7
terminal lipid7
protein accumulation7
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export sites7
secretion system7
kunjin virus7
mannose oligosaccharide7
transmembrane glycoprotein7
expressing wild7
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sequence alignment7
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carbohydrate may7
arabidopsis thaliana7
cell differentiation7
restricted mutant7
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useful insight7
retinitis pigmentosa7
molecular species7
phase separation7
different domains7
intestinal cells7
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silk gland7
signals within7
domain structure7
lipid domains7
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actin polymerization7
polarized distribution7
bona fide7
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dependent fashion7
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cell cytoplasm7
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england biolabs7
plasmids encoding7
vitro translated7
scale bar7
internalization signal7
clathrin coat7
coated pit7
fresh media7
cdna library7
calcium concentration7
lys met7
complex class7
frozen sections7
active gtp7
whole cells7
kexlp activity7
pick disease7
transferrin receptors7
early compartments7
likely due7
gene fusion7
yeast strains7
smooth tubular6
fusion machinery6
processing mannosidase6
specific interactions6
glucuronic acid6
vesicular model6
different secretory6
lipid interactions6
significant amount6
containing fcs6
induced membranes6
plaque assays6
fluorescent protein6
expression level6
vesicular structures6
acid linkers6
targeting sequence6
dolichol cycle6
transport model6
basolateral membranes6
chase labeling6
actively transported6
proteins exit6
small membrane6
structurally related6
mem brane6
tail contains6
potential anti6
cen plasmid6
also localized6
cells identification6