trigram

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trigram	frequency
as well as	457
the presence of	427
results suggest that	359
we found that	295
the effect of	289
in this study	279
in order to	279
these results suggest	267
the role of	262
the number of	254
in the presence	237
the expression of	232
the present study	218
the effects of	202
one of the	192
in the present	182
graduate school of	173
in the brain	170
involved in the	166
the development of	166
the formation of	162
cells in the	154
suggest that the	150
to investigate the	141
in response to	140
central nervous system	140
results indicate that	136
to determine the	135
school of medicine	131
we show that	131
role in the	129
of this study	128
was used to	124
neurons in the	123
the use of	122
been shown to	117
in cf patients	116
it has been	116
this study was	114
the absence of	114
based on the	114
we investigated the	113
compared to the	112
an important role	111
in patients with	110
the regulation of	110
we examined the	109
study was to	108
to study the	108
changes in the	106
an increase in	105
angelica tenuissima nakai	104
due to the	104
the plasma membrane	102
in vitro and	102
data suggest that	101
the level of	99
has been shown	98
in the absence	98
have shown that	97
observed in the	96
these results indicate	95
in addition to	94
was observed in	93
the central nervous	93
on the other	93
the aim of	93
found that the	92
important role in	92
were used to	90
can be used	90
the other hand	90
in the hippocampus	89
part of the	89
in cystic fibrosis	87
is involved in	87
with cystic fibrosis	86
green fluorescent protein	85
as compared to	85
a number of	85
be involved in	85
and in vivo	85
a role in	85
expressed in the	83
patients with cf	82
showed that the	81
a variety of	81
and in the	81
the amount of	80
the activation of	78
expression of the	78
analysis of the	78
we conclude that	78
has not been	77
increase in the	77
vitro and in	77
airway epithelial cells	76
is associated with	76
in contrast to	75
well as the	74
show that the	73
we have previously	73
our results suggest	71
in the regulation	71
nsp and nsp	71
be used to	71
the cells were	71
the rate of	71
the activity of	70
the function of	70
of cf patients	70
the treatment of	70
results show that	69
contribute to the	69
to determine whether	69
dorsal accessory calyx	68
the importance of	68
hek t cells	68
a total of	68
aim of this	67
to understand the	67
found to be	67
of the brain	67
university of tokyo	67
is one of	67
according to the	66
related to the	66
the control of	66
the mechanism of	65
as a result	65
the end of	65
department of physiology	65
is known to	65
associated with the	65
in terms of	64
children with cf	64
the dorsal accessory	64
known to be	64
these data suggest	64
findings suggest that	64
there was no	64
the cell surface	64
of the protein	64
we hypothesized that	63
the majority of	63
region of the	62
a decrease in	62
in the rat	61
effect on the	61
used as a	61
the influence of	61
indicate that the	60
the ability of	60
structure of the	59
are involved in	59
there is a	59
black flying fox	59
the most common	59
activation of the	59
the cystic fibrosis	59
were treated with	58
to examine the	58
a bp kenyon	58
in the adult	58
play a role	58
in the central	58
expression in the	58
to elucidate the	58
may contribute to	57
neural stem cells	57
is characterized by	57
most of the	57
bp kenyon cells	56
the study of	56
but not in	56
in which the	56
found in the	56
is known about	56
to evaluate the	56
in the cns	56
is required for	55
to identify the	55
were infected with	55
properties of the	55
end of the	55
role of the	55
in the cf	55
the impact of	54
of angelica tenuissima	54
little is known	54
the replication of	54
a combination of	54
the induction of	54
the spinal cord	54
is essential for	53
to be a	53
data not shown	53
we showed that	53
function of the	52
the interaction of	52
was found to	52
in the control	52
we have shown	51
we analyzed the	51
by means of	51
such as the	51
compared with the	51
had no effect	51
no effect on	51
significant increase in	51
shown to be	51
of the virus	50
the onset of	50
as shown in	50
play an important	50
the course of	50
of the disease	50
consistent with the	50
was associated with	50
are associated with	50
activity of the	50
cells of the	49
in the same	49
and found that	49
activity in the	49
was used as	49
the relationship between	49
we have developed	49
the basis of	49
respiratory syncytial virus	49
resulted in a	49
the levels of	49
of the gfp	49
a significant increase	48
were able to	48
for h at	48
the identification of	48
decrease in the	48
supported by the	48
suggesting that the	48
of the cell	48
the kinetics of	48
these findings suggest	48
for min at	48
for the treatment	48
the pathogenesis of	47
the percentage of	47
understanding of the	47
to assess the	47
university graduate school	47
to that of	47
the involvement of	47
in the developing	46
science and technology	46
the structure of	46
the surface of	46
with respect to	46
of the most	46
this study we	46
the existence of	46
for the first	46
at room temperature	46
was determined by	45
respiratory syndrome coronavirus	45
patients with cystic	45
the release of	45
member of the	45
institute of technology	45
the frequency of	45
has been reported	45
of the two	45
we used a	45
there were no	45
we studied the	45
present in the	44
the purpose of	44
of the membrane	44
demonstrated that the	44
plays an important	44
were observed in	44
is able to	44
the process of	44
to analyze the	43
the production of	43
cells were infected	43
we observed that	43
is thought to	43
national institute of	43
in the ca	43
have been shown	43
to determine if	43
the fact that	43
the increase in	43
may be a	42
compared to control	42
the distribution of	42
responsible for the	42
presence of a	42
the ability to	42
the molecular mechanisms	42
is an important	42
are known to	42
the analysis of	42
there was a	42
in situ hybridization	41
a member of	41
was supported by	41
a series of	41
the results of	41
at the end	41
cf patients with	41
we developed a	41
in combination with	41
university school of	41
our results indicate	40
mutations in the	40
quality of life	40
the case of	40
when compared to	40
severe acute respiratory	40
cystic fibrosis foundation	40
brain science institute	40
in the hippocampal	40
to characterize the	40
acute respiratory syndrome	40
the interaction between	39
here we show	39
before and after	39
this work was	39
is regulated by	39
will be discussed	39
were found in	39
data show that	39
a result of	39
well as in	39
the lack of	39
of cystic fibrosis	39
it is possible	39
associated with a	39
on the basis	39
formation of the	39
the generation of	39
in the development	39
the hypothesis that	38
were incubated with	38
with cf and	38
of the same	38
we propose that	38
a and b	38
the inhibition of	38
difference in the	38
in the spinal	38
thought to be	38
suggests that the	38
the mechanisms of	38
the extent of	38
for this purpose	38
in this work	38
did not affect	38
used to determine	38
of the human	38
is mediated by	38
the first time	38
appears to be	37
depending on the	37
in the cell	37
of the viral	37
a range of	37
results showed that	37
in comparison to	37
the binding of	37
all of the	37
western blot analysis	37
two types of	37
we hypothesize that	37
in the first	37
of the patients	37
in the dorsal	37
in living cells	37
effect of the	37
between the two	36
of the central	36
in the mouse	36
were found to	36
our results show	36
we observed a	36
gene expression in	36
characterization of the	36
were obtained from	36
to test the	36
the accumulation of	36
the time of	36
the contribution of	36
control of the	36
shown that the	36
we also found	36
is expressed in	36
as part of	35
than in the	35
in the number	35
have been reported	35
hepatitis b virus	35
differences in the	35
of the cells	35
atomic force microscopy	35
have demonstrated that	35
transmembrane conductance regulator	35
results demonstrate that	35
was detected in	35
the proportion of	35
flying fox cells	35
the addition of	35
the application of	35
the endoplasmic reticulum	35
be related to	35
change in the	34
this study is	34
presence of the	34
the concentration of	34
we found a	34
in the case	34
here we report	34
of patients with	34
was used for	34
revealed that the	34
members of the	34
the changes in	34
as described above	34
added to the	34
is important for	34
cells transfected with	34
bronchial epithelial cells	34
to explore the	34
were transfected with	33
years of age	33
astrocytes in the	33
were performed in	33
a role for	33
located in the	33
is based on	33
was performed using	33
purpose of this	33
was added to	33
the results suggest	33
studies have shown	33
cf lung disease	33
the university of	33
indicating that the	33
in the nucleolus	33
examined the effects	33
live cell imaging	33
of the cf	33
that of the	33
we demonstrate that	33
on the cell	33
detected in the	33
effects on the	32
adult cf patients	32
large number of	32
the a bp	32
of the cftr	32
the change in	32
were carried out	32
components of the	32
have been used	32
been reported to	32
each of the	32
the apical membrane	32
and that the	32
at the time	32
present study was	32
wide range of	32
to be involved	32
on the surface	32
effects of the	32
than that of	32
dependent on the	32
some of the	32
only in the	32
the loss of	32
a function of	32
to clarify the	32
did not show	32
which is a	32
in the expression	32
is consistent with	32
have previously shown	32
we used the	32
were analyzed by	32
herpes simplex virus	32
cystic fibrosis transmembrane	32
similar to the	31
to test this	31
correlated with the	31
we report that	31
are consistent with	31
h k me	31
at the same	31
national institute for	31
that can be	31
sod g a	31
the cerebral cortex	31
previously shown that	31
has been proposed	31
spinal cord injury	31
we have found	31
their ability to	31
we find that	31
increase of the	31
expression levels of	31
was applied to	31
proteins in the	31
to play a	31
was carried out	31
in relation to	31
data indicate that	31
fibrosis transmembrane conductance	31
regulation of the	31
we have recently	30
analysis revealed that	30
the efficacy of	30
we measured the	30
in vivo and	30
be due to	30
applied to the	30
acts as a	30
at least one	30
increased in the	30
a wide range	30
adults with cf	30
the age of	30
due to a	30
our data suggest	30
we demonstrated that	30
under the control	30
as a function	30
size of the	30
cells were transfected	30
been used to	30
we have used	30
the efficiency of	30
obtained from the	30
the size of	30
were used as	30
for the development	30
a large number	30
we present a	30
in lung function	29
surface of the	29
leads to a	29
key role in	29
significant difference in	29
were cultured in	29
in the membrane	29
we sought to	29
indicated that the	29
in comparison with	29
that in the	29
molecular dynamics simulations	29
we suggest that	29
a crucial role	29
influenza a virus	29
regions of the	29
was confirmed by	29
we tested the	29
in mammalian cells	29
of these cells	29
significant decrease in	29
t cells were	29
derived from the	29
we have identified	29
results indicated that	29
the dentate gyrus	29
airway surface liquid	29
has been used	29
the magnitude of	29
also found that	29
mechanism of action	29
we evaluated the	29
shown in figure	29
better understanding of	29
we have investigated	29
we are currently	29
study of the	29
a key role	29
p and p	28
c bl j	28
of neurons in	28
to the cell	28
different types of	28
is responsible for	28
japan we have	28
were used for	28
astrocytes and microglia	28
gaba a receptors	28
demonstrate that the	28
to measure the	28
a significant decrease	28
component of the	28
study is to	28
it is not	28
the dynamics of	28
was performed in	28
to better understand	28
as measured by	28
as a potential	28
results in a	28
mechanism by which	28
have developed a	28
we have studied	28
was found in	28
the possibility that	28
cells were incubated	28
identified in the	28
high levels of	28
morbidity and mortality	28
as described previously	28
will be presented	28
previously reported that	27
the gfp gene	27
in children with	27
an increase of	27
cd t cells	27
development of the	27
riken brain science	27
by western blot	27
which can be	27
was expressed in	27
japan in the	27
depends on the	27
the need for	27
the apical surface	27
the nervous system	27
thermo fisher scientific	27
receptors in the	27
used for the	27
department of anatomy	27
prior to the	27
the ratio of	27
known about the	27
could not be	27
have not been	27
was assessed by	27
the cell membrane	27
is the most	27
important roles in	27
form of the	27
total number of	27
not affect the	27
a model of	27
that there is	27
by flow cytometry	27
to be the	26
levels in the	26
an in vitro	26
these results demonstrate	26
as a model	26
the total number	26
insight into the	26
the localization of	26
to compare the	26
to the cells	26
led to the	26
inhibition of the	26
g a mice	26
the amplitude of	26
seen in the	26
in the study	26
vesicular stomatitis virus	26
the stability of	26
in the nucleus	26
of the p	26
work was supported	26
allowed us to	26
is crucial for	26
in the cerebellum	26
in agreement with	26
to interact with	26
similar to that	26
the ca region	26
in the pathogenesis	26
as previously described	26
are expressed in	26
vaccinated with chadox	26
no significant difference	26
we have demonstrated	26
activation in the	26
we were able	26
were exposed to	26
results suggested that	26
mechanism of the	26
but not the	26
in the lung	26
required for the	26
characterized by a	26
the properties of	25
crucial role in	25
the substantia nigra	25
has been suggested	25
to test whether	25
corresponding to the	25
to investigate whether	25
investigated the effects	25
cells infected with	25
was shown to	25
of the a	25
are able to	25
been shown that	25
the combination of	25
in the plasma	25
may play a	25
examined the effect	25
we have been	25
the hippocampus of	25
we examined whether	25
of the n	25
included in the	25
addition to the	25
to this end	25
to address this	25
stimulation of the	25
were measured by	25
relative to the	25
learning and memory	25
investigated the effect	25
cells treated with	25
recent studies have	25
it was shown	25
insights into the	25
of cftr in	25
this effect was	25
cells were then	25
none of the	25
supported by nih	25
the degree of	25
in the primary	25
in cf cells	25
and the other	25
side of the	25
we did not	25
department of physics	24
of the three	24
to the plasma	24
time course of	24
compared to wt	24
the gfp substrate	24
previous studies have	24
cystic fibrosis patients	24
in a single	24
roles in the	24
compared to those	24
cf patients and	24
the inflammatory response	24
we will discuss	24
cells were washed	24
neuronal activity in	24
reported to be	24
used to study	24
induced by the	24
of more than	24
are thought to	24
in presence of	24
it is well	24
of action of	24
department of molecular	24
of the study	24
of the host	24
expression of a	24
a group of	24
is critical for	24
of glial cells	24
appear to be	24
is due to	24
followed by a	24
a critical role	24
leads to the	24
this suggests that	24
based on a	24
use of the	24
the control group	24
is caused by	24
reactive oxygen species	24
contrast to the	24
molecular mechanisms of	24
the prevalence of	24
necessary for the	24
is necessary for	24
mediated by the	24
by the presence	24
due to its	24
cell death in	23
fold increase in	23
was inhibited by	23
we investigated whether	23
based on these	23
the lungs of	23
was to investigate	23
no significant differences	23
was also observed	23
we performed a	23
the detection of	23
highly expressed in	23
the culture medium	23
response in the	23
out of the	23
did not change	23
in the striatum	23
the study period	23
have found that	23
experiments were performed	23
cells were seeded	23
human bronchial epithelial	23
hela cells were	23
cells were fixed	23
analysis was performed	23
the r domain	23
and may be	23
by using a	23
were detected in	23
of a single	23
of purkinje cells	23
it is important	23
shown in fig	23
hepatitis c virus	23
was to determine	23
organization of the	23
in the human	23
the olfactory bulb	23
in the treatment	23
the duration of	23
a better understanding	23
development of a	23
there is no	23
focused on the	23
suggested that the	23
an inhibitor of	23
c bl mice	23
used in the	23
a set of	23
cells were treated	23
is dependent on	23
cloned into the	23
was able to	23
the green fluorescent	23
basis of the	23
is a key	23
no difference in	23
of astrocytes in	23
a reduction in	23
the wild type	23
of microglia in	23
may lead to	23
the sequence of	22
in our study	22
and inflammatory monocytes	22
and function of	22
the appearance of	22
analysis showed that	22
middle east respiratory	22
been reported in	22
of the s	22
in line with	22
these results suggested	22
modulation of the	22
has also been	22
the density of	22
type i interferon	22
supported by cff	22
the interaction with	22
correlation between the	22
the maintenance of	22
the brain of	22
more than one	22
the rat brain	22
gaba a receptor	22
we compared the	22
under these conditions	22
findings indicate that	22
in the auditory	22
during the first	22
type i ifn	22
of a novel	22
leading to the	22
allow us to	22
the possibility of	22
we determined the	22
or in the	22
the risk of	22
of the dna	22
is important to	22
were performed using	22
a significant difference	22
was shown that	22
in the airway	22
we have also	22
of the cellular	22
of infected cells	22
the cut site	22
human airway epithelial	22
half of the	22
in the olfactory	22
were prepared from	22
we focused on	22
as described in	22
department of chemistry	22
in the two	22
to the cf	22
be used as	22
the roles of	22
the innate immune	22
of the airway	22
in real time	22
the modulation of	22
remains to be	22
east respiratory syndrome	22
the molecular mechanism	22
distribution of the	22
plays a role	22
to the development	22
h ak ub	22
was performed to	22
of the hippocampus	21
rnai suppressor activity	21
for at least	21
with or without	21
the range of	21
this work is	21
porcine epidemic diarrhea	21
did not differ	21
cells were cultured	21
to the nucleus	21
glial cells in	21
cells compared to	21
is used to	21
information on the	21
led to a	21
neurons of the	21
in hek t	21
to improve the	21
sox cut sites	21
be able to	21
department of biophysics	21
is supported by	21
a mouse model	21
in the early	21
critical role in	21
at the cell	21
and on the	21
is not clear	21
on the contrary	21
contributes to the	21
to reveal the	21
and analyzed by	21
in the mammalian	21
its ability to	21
innate immune response	21
of cf lung	21
the design of	21
sequence of the	21
the potential of	21
the mushroom body	21
to the control	21
in cell culture	21
it was found	21
kindly provided by	21
of neural stem	21
in hela cells	21
formation of a	21
we have examined	21
are responsible for	21
of the pro	21
in regulation of	21
academy of sciences	21
not affected by	21
that has been	21
of the enzyme	21
our understanding of	21
in the cortex	21
is a member	21
the prefrontal cortex	21
has been demonstrated	21
in the visual	21
is a potent	21
spinal cord of	21
of type i	21
be associated with	21
the in vivo	21
with chadox mers	21
and it is	21
was no significant	21
in astrocytes and	21
response to the	21
animals vaccinated with	21
by measuring the	21
institute of neuroscience	21
of the rat	21
primary cultures of	21
in the lungs	21
of the main	21
is well known	20
this work we	20
the orf gene	20
position of the	20
as determined by	20
bound to the	20
dynamics of the	20
of the present	20
was found that	20
also known as	20
of the cns	20
number of reads	20
microglia in the	20
increased expression of	20
in the formation	20
in the substantia	20
cleavage of the	20
may be involved	20
of the lipid	20
we report the	20
was replaced with	20
be used for	20
to changes in	20
the molecular basis	20
the basal ganglia	20
to have a	20
cells were grown	20
conclude that the	20
was induced by	20
in the literature	20
to those of	20
in the cells	20
confocal laser scanning	20
this type of	20
to increase the	20
in the second	20
of the target	20
as assessed by	20
the pathophysiology of	20
was observed at	20
stem progenitor cells	20
act as a	20
state of the	20
expression of cftr	20
we speculate that	20
the progression of	20
we aimed to	20
not well understood	20
was measured by	20
to the apical	20
considered to be	20
the results showed	20
in the left	20
in cf and	20
the increase of	20
the administration of	20
were divided into	20
data demonstrate that	20
interaction with the	20
compared to controls	20
was increased in	20
neutrophils and inflammatory	20
as a control	20
found that a	20
play important roles	20
in the right	20
the potential to	20
of the first	20
bv or mlt	20
we previously reported	20
were expressed in	20
protein in the	20
increased the number	20
the characterization of	20
close to the	20
is possible to	20
of gaba a	20
resulting in the	20
nucleus of the	20
aim of the	20
by confocal microscopy	20
posterior lateral protocerebrum	20
the same time	20
responses in the	20
molecular mechanism of	19
institute for physiological	19
to estimate the	19
extract of angelica	19
function in the	19
mrna and protein	19
cf and non	19
the intensity of	19
even in the	19
the posterior lateral	19
a l p	19
part of a	19
u r n	19
lead to the	19
have been identified	19
to the same	19
level of the	19
o u r	19
the occurrence of	19
genes involved in	19
small number of	19
and incubated at	19
to confirm the	19
increased levels of	19
have reported that	19
with a high	19
vero e cells	19
washed with pbs	19
formation in the	19
at least in	19
o o f	19
dynamic light scattering	19
l p r	19
we generated a	19
we confirmed that	19
in this process	19
the action of	19
and of the	19
compared to wild	19
and stained with	19
p x r	19
neural progenitor cells	19
better understand the	19
r o o	19
is capable of	19
project to the	19
to the membrane	19
might be involved	19
significantly reduced in	19
the present work	19
red fluorescent protein	19
tokyo metropolitan institute	19
n a l	19
of chikungunya virus	19
p r o	19
and at the	19
patients with a	19
is the first	19
functions in the	19
the decrease in	19
and activation of	19
the location of	19
short circuit current	19
result suggests that	19
belongs to the	19
p r e	19
were collected from	19
department of pharmacology	19
serve as a	19
are essential for	19
course of the	19
our results demonstrate	19
antiviral activities of	19
binding to the	19
of the er	19
intensity of the	19
of the major	19
determine whether the	19
of membrane proteins	19
these results show	19
area of the	19
sites in the	19
also observed in	19
were included in	19
terminal domain of	19
influence of the	19
that activation of	19
in the protein	19
with and without	19
the activities of	19
in the er	19
in black flying	19
seems to be	19
j o u	19
significant changes in	19
have investigated the	19
r n a	19
was significantly higher	19
the synthetic viruses	19
respiratory epithelial cells	19
due to their	19
is related to	19
a subset of	19
have been developed	19
mouse model of	19
u os cells	19
for the study	19
in the lateral	19
epithelial cells and	19
could be detected	19
oligodendrocyte precursor cells	19
within the first	18
at the level	18
a change in	18
associated with an	18
respect to the	18
not only in	18
in the future	18
were associated with	18
which may be	18
mean age of	18
h after the	18
the context of	18
but also in	18
the interactions between	18
derived neurotrophic factor	18
a part of	18
of chadox mers	18
basis for the	18
was blocked by	18
did not significantly	18
together with the	18
similar to those	18
cftr in the	18
present study we	18
binds to the	18
investigate the effect	18
school of life	18
of these two	18
localization of the	18
in the past	18
are shown in	18
and characterization of	18
significant differences in	18
at the plasma	18
we report here	18
of the orf	18
the initiation of	18
the time course	18
of the c	18
bovine serum albumin	18
the establishment of	18
participate in the	18
the nature of	18
evidence suggests that	18
microglia and astrocytes	18
be explained by	18
results of the	18
to develop a	18
different time points	18
we are now	18
the site of	18
in the anterior	18
information about the	18
mechanisms underlying the	18
the current study	18
important for the	18
the cftr gene	18
was measured using	18
reduction in the	18
was no difference	18
location of the	18
inserted into the	18
used to assess	18
relationship between the	18
studies showed that	18
experiments showed that	18
test this hypothesis	18
localized in the	18
the objective of	18
crystal structure of	18
antiviral activity of	18
are present in	18
which has been	18
the proliferation of	18
balb c mice	18
regardless of the	18
cells from the	18
in accordance with	18
need to be	18
fetal bovine serum	18
in these cells	18
we have reported	18
interact with the	18
of the peptide	18
to the dorsal	18
that it is	18
reported that the	18
and suggest that	18
were stained with	18
cells and the	18
of these proteins	18
interaction of the	18
of the r	18
the viral genome	18
were seen in	18
decreased in the	18
is the major	18
b and c	18
cellular and molecular	18
of microglia and	18
stability of the	18
human immunodeficiency virus	17
affected by the	17
localized to the	17
agreement with the	17
more than of	17
patients in the	17
is observed in	17
of spinal cord	17
treatment of cf	17
that had been	17
both in vitro	17
previously demonstrated that	17
disruption of the	17
a role of	17
of the dentate	17
as compared with	17
as a consequence	17
of this work	17
and secretion of	17
evidence that the	17
presence or absence	17
were added to	17
time of the	17
spinal cord and	17
likely to be	17
molecular mechanisms underlying	17
the type of	17
cf patients who	17
essential for the	17
the host cell	17
with pseudomonas aeruginosa	17
of vitamin d	17
have been proposed	17
mechanisms by which	17
is a major	17
of viral rna	17
in the cerebral	17
determined by the	17
these results indicated	17
was designed to	17
lung function in	17
to infection by	17
loss of the	17
at different time	17
for physiological sciences	17
functional significance of	17
epidemic diarrhea virus	17
at the c	17
cells in a	17
carried out in	17
been implicated in	17
is possible that	17
infection of the	17
in the n	17
faculty of medicine	17
serves as a	17
the severity of	17
reduction of the	17
mechanism for the	17
from the same	17
that did not	17
of pulmonary exacerbations	17
in spite of	17
portion of the	17
of rna viruses	17
the pattern of	17
transiently transfected with	17
synaptic transmission in	17
for use in	17
from cf patients	17
a small number	17
could be a	17
patients who were	17
inhibitory effect of	17
that the expression	17
but did not	17
studies on the	17
for cystic fibrosis	17
at the beginning	17
were subjected to	17
was a significant	17
impact on the	17
involvement of the	17
wild type and	17
of science and	17
studies indicate that	17
to generate a	17
is required to	17
been associated with	17
resonance energy transfer	17
min at room	17
investigation of the	17
excitatory and inhibitory	17
was induced in	17
the response to	17
for more than	17
injected into the	17
performed in the	17
not observed in	17
in the hypothalamus	17
because of the	17
for in vivo	17
were identified as	17
metropolitan institute for	17
difference between the	17
the type i	17
in human cells	17
interfere with the	17
in the context	17
was evaluated by	17
referred to as	17
expression levels were	17
significantly higher in	17
institute for neuroscience	17
p y receptor	17
or absence of	17
is known that	16
cat k m	16
ca pyramidal neurons	16
these findings indicate	16
at uc for	16
of anatomy and	16
k cat k	16
the hippocampal ca	16
are not well	16
at our center	16
the expression levels	16
levels of the	16
of the sars	16
of the mouse	16
positive cells were	16
a model system	16
the cleavage site	16
oxidative stress and	16
the main calyx	16
this is a	16
lower than that	16
data from the	16
because of its	16
of lipid droplets	16
is believed to	16
it is unclear	16
the expression level	16
an moi of	16
well as to	16
caused by the	16
cf patients in	16
institute of biophysics	16
was increased by	16
the specificity of	16
equine encephalitis virus	16
recently reported that	16
at the n	16
japan science and	16
significantly reduced the	16
shows that the	16
the maturation of	16
was not affected	16
signals in the	16
viruses such as	16
in the ob	16
the nucleolus after	16
japan we examined	16
to the formation	16
objective of this	16
and incubated for	16
independent of the	16
was performed on	16
caused by a	16
we have now	16
the behavior of	16
advantage of the	16
were collected at	16
allows us to	16
be expressed in	16
of a new	16
of cell surface	16
with the same	16
during the study	16
which is the	16
were unable to	16
determination of the	16
venezuelan equine encephalitis	16
but it is	16
is sufficient to	16
the antiviral activity	16
rna binding motifs	16
peripheral nervous system	16
as early as	16
of lung disease	16
during the course	16
responses to the	16
goal of this	16
is poorly understood	16
the visual cortex	16
it is likely	16
of these patients	16
the growth cone	16
as a marker	16
proteins involved in	16
oligodendrocyte progenitor cells	16
also show that	16
activated protein kinase	16
fluorescence correlation spectroscopy	16
in this case	16
a powerful tool	16
is a highly	16
structure and function	16
the cf lung	16
results demonstrated that	16
were performed on	16
mutation in the	16
the genome of	16
used in this	16
infected cells were	16
the migration of	16
consistent with a	16
be found in	16
the translocation of	16
of the respiratory	16
incubated with the	16
is not known	16
the order of	16
mice treated with	16
with a mean	16
investigate the role	16
the sox cut	16
in the ventral	16
transfected with the	16
factors such as	16
have previously reported	16
the s protein	16
and the effect	16
patients and families	16
are used to	16
significantly increased the	16
used to measure	16
and end of	16
by using the	16
needs to be	16
the position of	16
of cells expressing	16
appeared to be	16
a consequence of	16
we concluded that	16
expression level of	16
supported by grants	16
gene expression of	16
levels were measured	16
were identified in	16
a loss of	16
and spinal cord	16
the morphology of	16
diseases such as	16
as one of	16
plasma membrane of	16
decline in lung	16
innate immune responses	16
and can be	16
with changes in	16
were maintained in	16
have studied the	16
be responsible for	16
it is known	16
with regard to	16
a marker for	16
that there are	16
in the current	16
in both the	16
compared with those	16
studies of the	16
in the table	15
of this protein	15
bl j mice	15
no change in	15
molecular basis of	15
model of the	15
the incidence of	15
semliki forest virus	15
is an essential	15
of expression of	15
and cells were	15
and compared to	15
when compared with	15
we investigate the	15
this is the	15
to be more	15
number of cells	15
of the mature	15
nucleolus after hs	15
in the peripheral	15
is increased in	15
in rat hippocampal	15
for h in	15
study suggests that	15
are required for	15
and did not	15
the population of	15
accordance with the	15
the presence and	15
more likely to	15
piglets in the	15
and treated with	15
rate of decline	15
kyushu institute of	15
of pharmaceutical sciences	15
cystic fibrosis is	15
strand rna viruses	15
important role of	15
have been found	15
these cells were	15
is likely to	15
an essential role	15
lead to a	15
the hippocampus and	15
the identity of	15
the introduction of	15
and mortality in	15
is not well	15
production of il	15
expression was observed	15
higher in the	15
in the range	15
a population of	15
primary motor cortex	15
the survival of	15
indicates that the	15
these results provide	15
the secretion of	15
but not by	15
of pseudomonas aeruginosa	15
the results show	15
enriched in the	15
broad spectrum of	15
of our study	15
gfp fusion protein	15
middle cerebral artery	15
been proposed to	15
of children with	15
inflammatory response in	15
magnetic resonance imaging	15
school of medical	15
site of the	15
to wild type	15
of up to	15
the cells with	15
be important for	15
the corpus callosum	15
input from the	15
assumed to be	15
neurons and astrocytes	15
to provide a	15
individuals with cf	15
the brain and	15
in vitro transcription	15
kinetics of the	15
this process is	15
significant reduction in	15
of the green	15
a panel of	15
suggest that a	15
will discuss the	15
functional role of	15
the presence or	15
cf patients were	15
linked to the	15
vitamin d deficiency	15
is likely that	15
are poorly understood	15
implicated in the	15
areas of the	15
a useful tool	15
was accompanied by	15
that have been	15
early stages of	15
the effectiveness of	15
and incubated with	15
nature of the	15
on the membrane	15
patients were included	15
in the dentate	15
of neurons and	15
were seeded in	15
school of science	15
incubated for h	15
is expected to	15
days in vitro	15
human and mouse	15
was seen in	15
we carried out	15
of the f	15
an animal model	15
have to be	15
did not have	15
department of neurology	15
of cell biology	15
cultured cortical neurons	15
in gene expression	15
cells that were	15
the correlation between	15
a pulmonary exacerbation	15
of both the	15
a reduction of	15
those in the	15
the results obtained	15
in all the	15
length of the	15
change in fev	15
result in a	15
in pc cells	15
these data indicate	15
of the channel	15
a recent study	15
morris water maze	15
well known that	15
mechanisms of the	15
using the same	15
resulting in a	15
of severe acute	15
quantitative analysis of	15
fused to the	15
followed by the	15
in airway epithelial	15
of the left	15
a central role	15
in t cells	15
in both cell	15
is still unclear	15
cells with the	15
supplemented with fetal	15
have also been	15
also in the	15
terminal processing site	15
were stimulated with	15
has been previously	15
for treatment of	15
were determined by	15
positive cells in	15
to contribute to	15
specificity of the	15
in the process	15
protein expression in	15
cells with a	15
identified as a	15
can also be	15
total rna was	15
the beginning of	15
the most frequent	15
in glial cells	15
of gene expression	15
their role in	15
involved in this	15
expression pattern of	15
significant increase of	15
the mature form	15
magnitude of the	15
in the airways	15
each of these	15
interactions between the	14
in live cells	14
in human and	14
to be expressed	14
it is a	14
physiological role of	14
transmission in the	14
we have generated	14
mice in which	14
has recently been	14
the quality of	14
in cfbe o	14
was present in	14
patients who had	14
reporter gene expression	14
the uptake of	14
features of the	14
in vivo studies	14
the degradation of	14
lower in the	14
has been known	14
adolescents with cf	14
activity and the	14
as a novel	14
the goal of	14
and expression of	14
and differentiation of	14
dorsal root ganglion	14
the brains of	14
significantly increased in	14
higher levels of	14
in the last	14
of cl pro	14
the insertion of	14
a mutation in	14
school of pharmaceutical	14
with chadox gfp	14
the reduction of	14
not in the	14
functions of the	14
in transgenic mice	14
account for the	14
of the total	14
a measure of	14
department of neurophysiology	14
hypothesized that the	14
the fraction of	14
to the presence	14
in cf sputum	14
be one of	14
and in vitro	14
the determination of	14
of the sox	14
parts of the	14
pyramidal neurons in	14
have examined the	14
pediatric and adult	14
by increasing the	14
of the other	14
was observed between	14
the airway epithelial	14
the relevance of	14
was defined as	14
mechanical properties of	14
activation of microglia	14
away from the	14
italian institute of	14
a final concentration	14
in a dose	14
surface expression of	14
and examined the	14
sites of the	14
in the tgev	14
the auditory cortex	14
identification of the	14
channels in the	14
of changes in	14
presented in the	14
with an increase	14
different brain regions	14
has been developed	14
in the non	14
considered as a	14
in the culture	14
of the cleavage	14
detection of the	14
amino acid residues	14
and the number	14
the two groups	14
the removal of	14
open reading frame	14
in cf airways	14
a period of	14
with those of	14
days of age	14
which leads to	14
the direction of	14
to an increase	14
by the cf	14
suggest that these	14
maintenance of the	14
of the proteins	14
decline in fev	14
laser scanning microscopy	14
different from that	14
of the adult	14
were generated by	14
there is an	14
processes in the	14
we found the	14
were no significant	14
the structure and	14
to form a	14
has been described	14
in epithelial cells	14
well as a	14
of chikv ls	14
interactions with the	14
with pbs and	14
ca region of	14
in wt mice	14
of inflammatory monocytes	14
with cf were	14
the idea that	14
studies were performed	14
rat hippocampal slices	14
of the four	14
consistent with previous	14
a significant reduction	14
we propose a	14
at the surface	14
importance of the	14
for cf patients	14
characteristics of the	14
our data show	14
in vivo imaging	14
play a key	14
to be associated	14
the primary visual	14
this result suggests	14
to detect the	14
reduced in the	14
male and female	14
from the lungs	14
here we investigated	14
in recent years	14
is essential to	14
we aim to	14
for patients with	14
as in the	14
of life science	14
the expression and	14
under physiological conditions	14
influenced by the	14
results suggest the	14
as an important	14
kenyon cells receive	14
m and m	14
as a positive	14
and molecular mechanisms	14
is accompanied by	14
absence of the	14
was detected with	14
primary visual cortex	14
dependence of the	14
manipulation of the	14
min at uc	14
left and right	14
activities of the	14
study aimed to	14
of influenza a	14
soluble form of	14
was identified as	14
brain research institute	14
not involved in	14
of the cd	14
as shown by	14
to the nucleolus	14
any of the	14
in a cell	14
the sensitivity of	14
final concentration of	14
cells were also	14
the mechanism by	14
was monitored by	14
results in the	14
in this population	14
is a useful	14
was significantly increased	14
which have been	14
the recovery of	14
was bound to	14
mice compared to	14
to reduce the	14
been reported that	14
fraction of the	14
and western blot	14
in the apical	14
b and d	14
of the gene	14
of the dorsal	14
of these neurons	14
between these two	14
in figure a	14
the adult brain	14
functions as a	14
activities in the	14
were grown in	14
aqueous extract of	14
the first step	14
was not observed	14
we report a	13
can be a	13
is similar to	13
h at uc	13
three independent experiments	13
in conjunction with	13
cell adhesion molecules	13
both in the	13
in vitro studies	13
it is still	13
the mechanisms underlying	13
to investigate how	13
it may be	13
of the tgev	13
as indicated by	13
been linked to	13
caused by mutations	13
was analyzed by	13
have suggested that	13
by western blotting	13
induced by a	13
of age and	13
department of cell	13
for minutes at	13
when exposed to	13
subjects with cf	13
was significantly reduced	13
compared to that	13
leading to a	13
in the mutant	13
the synthesis of	13
of the cut	13
and technology agency	13
is necessary to	13
to the c	13
the inner ear	13
of the different	13
were transiently transfected	13
our cf center	13
in our laboratory	13
step in the	13
were classified as	13
the fate of	13
with that of	13
was related to	13
be a useful	13
are required to	13
a previous study	13
for the detection	13
activated cell sorting	13
not significantly different	13
funded by the	13
at the start	13
medial prefrontal cortex	13
one of these	13
we attempted to	13
proteins such as	13
in expression of	13
the ventral accessory	13
of biophysics and	13
the cf team	13
in well plates	13
expression patterns of	13
the functional role	13
were collected and	13
of the mutant	13
different from the	13
has shown that	13
amyotrophic lateral sclerosis	13
the amino acid	13
at an moi	13
the processing of	13
many of the	13
western blot and	13
the authors declare	13
to address the	13
may be due	13
was identified in	13
structures of the	13
which could be	13
egfp reporter gene	13
of the reporter	13
those of the	13
changes of the	13
to visualize the	13
give rise to	13
to define the	13
than that in	13
the volume of	13
a decrease of	13
virus infection in	13
cell patch clamp	13
order to determine	13
there have been	13
of a small	13
and changes in	13
not fully understood	13
was removed and	13
of p x	13
and s b	13
supernatants were collected	13
of such a	13
our findings suggest	13
rna was extracted	13
membrane expression of	13
in this model	13
onset of the	13
c and d	13
role of these	13
to establish the	13
japan we investigated	13
we identified a	13
central role in	13
recovery of the	13
by grants from	13
was injected into	13
significant difference between	13
of the mammalian	13
in the pathophysiology	13
recovery after photobleaching	13
in pulmonary function	13
of the interaction	13
its role in	13
ventral accessory calyx	13
the most important	13
especially in the	13
used to monitor	13
damage in the	13
not yet been	13
of viral replication	13
by addition of	13
myelin basic protein	13
is the main	13
of the ca	13
washed three times	13
using the r	13
the length of	13
to examine whether	13
concentration of the	13
in a wide	13
are likely to	13
resulted in the	13
by rna interference	13
the airway epithelium	13
has to be	13
cf bronchial epithelial	13
aspects of the	13
are the most	13
the present results	13
representation of the	13
different cell types	13
the optic lobe	13
of the genome	13
was performed with	13
due to an	13
that inhibition of	13
depend on the	13
a major role	13
was similar to	13
coding region of	13
transmission electron microscopy	13
of microglial cells	13
studies suggest that	13
cell lines were	13
of neutralizing antibodies	13
fos expression in	13
tokyo university of	13
the phosphorylation of	13
the p y	13
the components of	13
did not observe	13
to further investigate	13
formed by the	13
domain of the	13
gene in the	13
in a large	13
hippocampal ca region	13
as evidenced by	13
were incubated for	13
to obtain a	13
and some of	13
our data indicate	13
layer of the	13
virus replication in	13
here we present	13
in cf is	13
been used for	13
consistent with this	13
cerebral cortex and	13
specifically in the	13
that most of	13
is needed to	13
alterations in the	13
removal of the	13
in the basal	13
of patients were	13
the same as	13
to the surface	13
of the non	13
isolated from the	13
been suggested that	13
resulted in an	13
of hepatitis b	13
and has been	13
the immune response	13
whether or not	13
pcr products were	13
by the cystic	13
the cf patients	13
could contribute to	13
may be useful	13
we found no	13
the subventricular zone	13
stages of the	13
the left and	13
to monitor the	13
with fetal bovine	13
the na k	13
increased risk of	13
some of them	13
infants with cf	13
comparison of the	13
of the signal	13
a mixture of	13
higher than the	13
by mass spectrometry	13
were compared with	13
and distribution of	13
on the same	13
the molecular level	13
apical surface of	13
test the hypothesis	13
provide evidence that	13
the emergence of	12
in wild type	12
provided by the	12
is a powerful	12
in the other	12
of the complex	12
cd and cd	12
plays a key	12
cells were observed	12
studies have demonstrated	12
which in turn	12
we also examined	12
expression of p	12
structure and dynamics	12
the results indicate	12
p y receptors	12
recorded from the	12
caused a significant	12
was quantified by	12
to a significant	12
associated with increased	12
was significantly lower	12
lung disease in	12
and loss of	12
adult patients with	12
superior lateral protocerebrum	12
may not be	12
of pcg proteins	12
in cells infected	12
for studying the	12
these data show	12
characterization of a	12
consists of a	12
consists of two	12
might contribute to	12
upstream of the	12
is a novel	12
was to evaluate	12
study we have	12
trafficking to the	12
time in the	12
into the brain	12
were performed to	12
were measured in	12
a cells were	12
aid for scientific	12
mg kg day	12
is composed of	12
have previously demonstrated	12
the evolution of	12
the deletion of	12
of the binding	12
nuclear translocation of	12
induction of the	12
of the chromophore	12
showed a significant	12
plasma membrane expression	12
animal model of	12
was obtained from	12
a positive control	12
based on our	12
of at least	12
the fusion of	12
of the second	12
institutes of health	12
lung function and	12
the mechanism underlying	12
inhibitory effects of	12
bv and mlt	12
was detected by	12
and glial cells	12
cleavage sites in	12
the stimulation of	12
of the peripheral	12
the gene encoding	12
this study aimed	12
the mean fev	12
pyramidal cells in	12
lc and lamp	12
was abolished by	12
males and females	12
times with pbs	12
the assembly of	12
under the same	12
of neuronal activity	12
pattern of the	12
a family of	12
a model for	12
may have a	12
p and ndp	12
in more detail	12
t rna polymerase	12
of lung function	12
transgenic chicken embryos	12
a new method	12
some of these	12
that could be	12
it would be	12
rat spinal cord	12
glial cells and	12
of wild type	12
that they have	12
the expression pattern	12
of the sample	12
been suggested to	12
excitation and emission	12
to the central	12
yellow fluorescent protein	12
is affected by	12
the f del	12
understand the role	12
with a significant	12
free protein synthesis	12
patients compared to	12
and the expression	12
proportional to the	12
that expression of	12
a potential therapeutic	12
we constructed a	12
the active site	12
in a significant	12
of the infection	12
changes induced by	12
mainly due to	12
the actin cytoskeleton	12
to the a	12
the autophagy pathway	12
gfp expression was	12
at least three	12
in the cftr	12
protein quality control	12
and dynamics of	12
the crystal structure	12
site in the	12
and protein expression	12
to control the	12
of virus replication	12
is widely used	12
were processed for	12
programmed cell death	12
a hallmark of	12
after h of	12
the fluorescence intensity	12
hek t and	12
roles of the	12
both cell types	12
in ng cells	12
of the glial	12
in our cf	12
of the receptor	12
by activation of	12
the most effective	12
the superior lateral	12
the construction of	12
using a combination	12
care and use	12
the utility of	12
has previously been	12
zone of the	12
binding of the	12
from that of	12
of decline in	12
for scientific research	12
the transcription factor	12
they do not	12
be required for	12
in this region	12
restricted to the	12
bronchial epithelial cell	12
phosphorylation of the	12
used to identify	12
vitamin d levels	12
information from the	12
of the visual	12
in clinical trials	12
the respiratory tract	12
in the cytoplasm	12
in vero cells	12
was cloned into	12
tenuissima nakai extracts	12
would like to	12
cerebral artery occlusion	12
the in vitro	12
in astrocytes in	12
we have established	12
in a mouse	12
in subjects with	12
attributed to the	12
the elp tag	12
were detected by	12
lung epithelial cells	12
predicted to be	12
with the use	12
induced cell death	12
that the protein	12
were purchased from	12
were isolated from	12
an in vivo	12
the mode of	12
not appear to	12
genes in the	12
in the medial	12
s and s	12
of the genes	12
processing in the	12
in this paper	12
were inoculated with	12
a and a	12
but also the	12
the nmda receptor	12
in case of	12
was assessed in	12
cultured hippocampal neurons	12
of the molecular	12
interacts with the	12
the vicinity of	12
and inhibition of	12
has been identified	12
of a large	12
cf patients are	12
nippon medical school	12
cell biology and	12
least in part	12
who did not	12
role for the	12
comparison with the	12
different concentrations of	12
was determined using	12
it is also	12
from those of	12
from the cell	12
use of a	12
the other two	12
of the fluorescence	12
plays a crucial	12
in both groups	12
events in the	12
mouse models of	12
medium supplemented with	12
deletion of the	12
our preliminary results	12
not been well	12
the growth of	12
low levels of	12
is present in	12
has been observed	12
transfection efficiency of	12
result of the	12
accumulate in the	12
reported in the	12
could be involved	12
the phenotype of	12
weeks of age	12
may be important	12
different from those	12
the start of	12
through the activation	12
were incubated at	12
adjacent to the	12
ability of the	12
the lipid bilayer	12
was measured in	12
was reported to	12
essential role in	12
model for the	12
we use a	12
in activated microglia	12
and to the	11
was to examine	11
several types of	11
the r h	11
of synaptic plasticity	11
u and u	11
and an increase	11
differentiated respiratory epithelial	11
the cf center	11
is not a	11
months of age	11
results suggest a	11
epithelial cells were	11
to play an	11
to follow the	11
cut site in	11
in animal models	11
cortex and hippocampus	11
work was to	11
university of tsukuba	11
were fixed and	11
for h and	11
present on the	11
could lead to	11
we do not	11
could be found	11
in the supernatant	11
targeted rna recombination	11
goal is to	11
was significantly decreased	11
of cells with	11
bronchoalveolar lavage fluid	11
presence of two	11
frequency of the	11
to be important	11
lapse imaging of	11