Questions

This is a list of all the questions and their associated study carrel identifiers. One can learn a lot of the "aboutness" of a text simply by reading the questions.

identifier question
cord-263165-bv4dh9eum klinischen Verlauf der Coronavirusinfektion der Schweine Lactogenic immunity to transmissible gastroenteritis of swine Relationship among transmissible gastroenteritis virus antibody titers in serum, colostrum, and milk from vaccinated sows, and protection in their suckling pigs Isolation of a porcine respiratory, non- enteric, coronavirus related to transmissible gastroenteritis New porcine coronavirus?
cord-271831-vekok62kI feline coronavirus infection Natural history of a recurrent feline coronavirus infection and the role of cellular immunity in survival and disease Effects of origin and state of differentiation of monocytes/ macrophages on their susceptibility to porcine reproductive and respiratory syndrome virus( PRRSV) FIP, easy to diagnose?
cord-291858-e0s3o2r4The prevalence of types I and II feline coronavirus infections in cats Differences in virus receptor for type I and type II feline infectious peritonitis virus Identification and genotyping of feline infectious peritonitisassociated single nucleotide polymorphisms in the feline interferon- gamma gene 3C protein of feline coronavirus inhibits viral replication independently of the autophagy pathway Deletions in the 7a ORF of feline coronavirus associated with an epidemic of feline infectious peritonitis Detection of feline coronavirus in captive Felidae in the USA Evaluation of antibodies against feline coronavirus 7b protein for diagnosis of feline infectious peritonitis in cats Topology of microvillar membrance hydrolases of kidney and intestine Feline infectious peritonitis: still an enigma?
cord-329642-5t8yuq4verythematosus Human coronavirus EMC does not require the SARScoronavirus receptor and maintains broad replicative capability in mammalian cell lines Reduction of immune activation with chloroquine therapy during chronic HIV infection Monoclonal antibodies to the spike protein of feline infectious peritonitis virus mediate antibody- dependent enhancement of infection of feline macrophages Chloroquine administration does not prevent Nipah virus infection and disease in ferrets A review of feline infectious peritonitis virus infection: 1963- 2008 Immunologic phenomena in the effusive form of feline infectious peritonitis Activation of p38 MAPK by feline infectious peritonitis virus regulates pro- inflammatory cytokine production in primary blood- derived feline mononuclear cells Effect of feline interferon- omega on the survival time and quality of life of cats with feline infectious peritonitis Effects of chloroquine on viral infections: an old drug against today's diseases?
cord-309205-l8vjtrjqThe prevalence of types I and II feline coronavirus infections in cats Protease- mediated entry via the endosome of human coronavirus 229E Deletions in the 7a ORF of feline coronavirus associated with an epidemic of feline infectious peritonitis Feline infectious peritonitis: still an enigma?
cord-311625-d7iycdyhAntibody- dependent enhancement occurs upon re- infection with the identical serotype virus in feline infectious peritonitis virus infection Feline infectious peritonitis viruses arise by mutation from endemic feline enteric coronaviruses Intrahost diversity of feline coronavirus: a consensus between the circulating virulent/ avirulent strains and the internal mutation hypotheses?
cord-345863-j01l71dhIt is, however, likely that host immune responses play a significant, but not sufficiently elucidated, role in the pathogenesis, and the question remains: What are the responses by the macrophages when infected with FCoV?
cord-299976-36r794owThe prevalence of types I and II feline coronavirus infections in cats Characterization of monoclonal antibodies against feline infectious peritonitis virus type II and antigenic relationship between feline, porcine, and canine coronaviruses Expression of feline infectious peritonitis coronavirus antigens on the surface of feline macrophage- like cells Detection of feline coronavirus in captive Felidae in the USA Reversal of the progression of fatal coronavirus infection in cats by a broad- spectrum coronavirus protease inhibitor Broad- spectrum antivirals against 3C or 3C- like proteases of picornaviruses, noroviruses, and coronaviruses Potent inhibition of feline coronaviruses with peptidyl compounds targeting coronavirus 3C- like protease Broad- spectrum inhibitors against 3C- like proteases of feline coronaviruses and feline caliciviruses Feline infectious peritonitis: still an enigma?
cord-336639-jaue41mvA study of naturally occurring feline coronavirus infections in kittens Using direct immunofluorescence to detect coronavirus in peritoneal and pleural effusions Sequence analysis of the 3-end of the feline coronavirus FIPV 79- 1146 genome: comparison with the genome of porcine coronavirus TGEV reveals large insertions FIP, easy to diagnose?
cord-323805-9n63ms3cwhat's in the genes?
cord-330554-xg49fochMultiple cyclophilins involved in different cellular pathways mediate HCV replication Immunophilins: switched on protein binding domains?
cord-351955-9l4786lbHowever, what are the alternatives?
cord-276617-chgjpg0vCD21?
cord-276617-chgjpg0vIn contrast, the ratio of sIg?
cord-276617-chgjpg0vThe ratio of sIg?
cord-276617-chgjpg0vWe reported previously that when the FIPV antigen was detected by the fluorescent antibody method, 10- 20% of cells were positive when SPF cat- derived alveolar macrophages were inoculated with FIPV?
cord-311982-wkg56xeqAre all coronavirus positive cats within a household infected with the same viral strain and are some cats co- infected with several FCoV strains simultaneously?
cord-311982-wkg56xeqFor example, does the FCoV strain within a defined multi- cat population remain conserved over time or are new strains constantly emerging?
cord-311982-wkg56xeqIf new strains do emerge, are they the result of original strain mutation or'de novo'infections from external sources?
cord-311982-wkg56xeqIs the FCoV strain present in the gut always a reflection of the predominant systemic strain, and similarly, do cats with FIP excrete pathogenic FIPV or only FECV?
cord-311982-wkg56xeqIs there a consistent mutation associated with pathogenicity?
cord-356112-c32icxirOn PCD 0,7,14, 21 and 28 the kittens were mildly sedated with ketamine HCl( VetalarTM, Parke, Davis& Co, Detroit, MI) given intramuscularly( 10 mg/ kg) and blood samples were collected from the external jugular vein into vacuum- evacuated blood collection tubes( Vacutaine?, Becton Dickinson& Co, Columbus, NB).
cord-356112-c32icxirOther investigators have r&c?
cord-346321-drhiqch0It has also been shown that Fc 7 R I and II are present on human macrophages and that mouse IgG 2a and IgG 1 bind well to the Fc?
cord-346321-drhiqch0MAb 3G8 is a mouse IgG 1 antibody that reacts with human Fc?
cord-346321-drhiqch0Therefore we assumed that mouse IgG 2a antibodies can bind Fc?
cord-346321-drhiqch0These results suggest that U937 cells of human origin have no virus receptor for FIPV, but Fc?
cord-290540-r0d6oaezHow do FIP- inducing coronaviruses arise?
cord-290540-r0d6oaezOne important question is: do we really want to protect against the FIPV infection?
cord-290540-r0d6oaezSo who is the enemy?
cord-290540-r0d6oaezWhat are the correlates of protection?
cord-290540-r0d6oaezWhat is the origin of the coronaviruses causing FIP?
cord-290540-r0d6oaezWhat is the origin of the serotype II, what is the molecular basis for the serotypes?
cord-283132-rfw8njpoA second question is what are the specific viral components which mediate ADE of infectivity for each virus?
cord-283132-rfw8njpoDoes the subclass of a given Ab determine whether it is able to mediate both neutralization and ADE of virus infectivity?
cord-283132-rfw8njpoFor instance, which receptors mediate ADE of virus infectivity?
cord-283132-rfw8njpoGiven the immune- mediated pathogenesis of FIP, what is the basis for protective immunity to FIPV infection?
cord-283132-rfw8njpoIBV Do antibodies enhance the infection of cells by HIV?
cord-283132-rfw8njpoMechanistically, how does the binding of enhancing Ab to a particular epitope on a virus induce an increase in virus infectivity?
cord-283132-rfw8njpoWill antibody- dependent enhancement of HIV-1 infection be a problem with AIDS vaccines Complement- mediated antibody- dependent enhancement of HIV-1 infection requires CD4 and complement receptors Antibody- dependent enhancement of human immunodeficiency virus type 1( HIV-1) infection in vitro by serum from HIV- l- infected and passively immunized chimpanzees Disease exacerbation caused by sequential dengue infections: myth or reality?
cord-292570-618bt2vh( TFAR19): an early signal for apoptosis?
cord-292570-618bt2vhA mRNA PCR for the diagnosis of feline infectious peritonitis Feline infectious peritonitis viruses arise by mutation from endemic feline enteric coronaviruses Feline infectious peritonitis: still an enigma?
cord-292570-618bt2vhOn the other hand, decreased of TNF- a along with high amount of IFN- c and IL-1b resulted in the augmentation of these CD8?
cord-292570-618bt2vhPrevious studies have highlighted that the augmentation of TNF- a production by FIPV and the possible role of adipokine in apoptosis induction and depletion of CD8?
cord-292570-618bt2vhStudies have reported that apoptosis of mononuclear cells and particularly CD8?
cord-292570-618bt2vhStudy has shown that TNF- a released from macrophages of FIP cats, induced apoptosis in lymphocytes, particularly CD8?
cord-023053-j061ywrlCan an infected queen infect her kittens in utero?
cord-023053-j061ywrlFor how long do infected cats harbour the virus?
cord-023053-j061ywrlFor how long do they excrete the virus, and by what route(s)?
cord-023053-j061ywrlHow, then, does the virus maintain itself in these animals?
cord-023053-j061ywrlIf so, does in utero infection result in disease?
cord-023053-j061ywrlIs excretion continuous or intermittent?
cord-023053-j061ywrlIs it possibly stress- related?
cord-023053-j061ywrlTo what extent is a coronavirus antibody- positive cat a potential disease threat to other cats with which it may come into contact?
cord-023053-j061ywrlWhat percentage of cats infected with FIPV actually become chronic carriers?
cord-023053-j061ywrlWhat route is most important for effective virus transmission to other cats?
cord-312006-c08u4t16How can a ubiquitous and largely non- pathogenic enteric coronavirus transform into a highly lethal pathogen?
cord-312006-c08u4t16Potent inhibition of feline coronaviruses with peptidyl compounds targeting coronavirus 3C- like protease Feline infectious peritonitis: Still an enigma?
cord-312006-c08u4t16What are the interactions between host and virus that determine both disease form( wet or dry) and outcome( death or resistance)?
cord-312006-c08u4t16What role do genetics play in disease susceptibility?
cord-312006-c08u4t16Why is it so difficult, and perhaps impossible, to develop a vaccine for FIP?
cord-312006-c08u4t16inhibit apoptosis of infected macrophages?