bigram

This is a table of type bigram and their frequencies. Use it to search & browse the list to learn more about your study carrel.

bigram frequency
ebola virus1510
ebov gp464
marburg virus258
virus infection257
virus disease252
hemorrhagic fever242
ebov infection237
virus glycoprotein174
nonhuman primates134
type i128
respiratory syndrome118
vesicular stomatitis113
dendritic cells110
ebola hemorrhagic107
sierra leone105
host cell99
stomatitis virus97
virus entry95
amino acid92
public health91
west africa88
cell surface88
antiviral activity85
democratic republic85
infected cells84
like particles83
immune responses83
plasma membrane81
viral replication80
rna viruses80
cell lines80
viral load79
syndrome coronavirus79
immune response78
target cells76
guinea pigs76
pseudotyped virus76
viral entry75
haemorrhagic fever75
cell entry74
acute respiratory73
marburg viruses72
zaire ebolavirus71
infectious diseases70
monoclonal antibodies68
neutralizing antibodies68
influenza virus68
middle east67
viral rna66
immunodeficiency virus66
severe acute65
neutralizing antibody63
filovirus infection61
virus vp60
evd patients59
cord uid58
doc id58
filovirus entry58
east respiratory57
fruit bats55
rhesus macaques55
human immunodeficiency54
west african54
rna polymerase53
binding site53
cell types52
previously described52
ebov vp52
membrane fusion52
viral infection52
i ifn52
marburg hemorrhagic52
matrix protein51
ebov entry51
fever virus51
cell culture50
virus replication49
mg kg48
cell fusion48
virus infections48
gp pseudotyped47
low ph46
room temperature46
endothelial cells46
ebola viruses46
clinical trials46
enveloped viruses45
gp cl45
cynomolgus macaques45
effector cells45
ebola outbreak45
world health45
health organization45
host cells43
approved drugs43
fruit bat42
infectious disease41
mg ml41
ebola haemorrhagic41
infected patients41
marv gp40
united states39
vp protein39
monoclonal antibody39
class i38
cell line38
viral proteins38
thermo fisher38
tetherin antagonism37
based vaccine37
western africa37
animal models36
evd outbreak36
small molecule35
positive cells35
mouse model35
virus particles35
cellular entry35
amino acids35
colored fruit35
live ebov34
african straw34
envelope glycoprotein34
fisher scientific34
described previously34
fusion protein34
avian influenza34
lethal ebola33
gene expression33
virus transmission33
phase i33
case fatality33
biosafety level32
ebov genome32
zaire ebola32
virus type32
pseudotyped hiv32
fecal samples32
health care32
fatality rate32
antibody titers32
glycan cap32
antibody responses32
viral envelope32
dendritic cell31
nipah virus31
genome sequences31
stranded rna31
ifn signaling31
viral fusion31
recombinant vesicular31
dependent rna31
clinical trial31
huh cells31
viral particles31
respiratory tract31
rna virus30
cell epitope30
viral genome30
lethal challenge30
highly pathogenic30
host immune30
purifying selection30
fusion loop30
immune system30
pfu ml30
equine antisera30
may also30
receptor binding30
i interferon29
innate immune29
virus gp29
viral infections29
blood samples29
life cycle29
hela cells29
ebov replication29
human infection29
npc domain29
pseudotyped viruses29
data sets29
sars coronavirus29
vaccine candidates28
hendra virus28
filovirus disease28
like particle28
gp i28
nonhuman primate28
ebov glycoprotein27
based vaccines27
bat cells27
viral protein27
guinea pig27
cell responses27
host range27
human primates26
cell epitopes26
virus challenge26
influenza viruses26
sexual transmission26
mucin domain26
reporter gene26
tnc mutations26
dna conjugates26
ebolavirus glycoprotein25
antibody response25
linked immunosorbent25
vaccine development25
glycoprotein gp25
human cases25
population coverage25
virus glycoproteins25
cholesterol transporter25
rna synthesis24
ebov infected24
animal model24
complete protection24
nucleic acid24
highly conserved24
vaccine design24
statistically significant24
negative control24
rhesus monkeys24
viral glycoprotein24
ebov outbreak24
incubation period24
proteolytic processing24
infected animals24
dengue virus24
ifn system23
fusion proteins23
rousettus aegyptiacus23
emerging pathogens23
viral spread23
electron microscopy23
vlp entry23
marv vp23
binding domain23
reverse transcription23
cov infection23
minigenome rna23
soluble non23
ng ml23
important role23
zaire ebov22
protein vp22
innate immunity22
virus outbreak22
human cells22
ebov infections22
ifitm proteins22
lethal ebov22
wide range22
ebola vaccine22
like domain22
peptide vaccine22
viral hemorrhagic22
high levels22
western blot22
previous studies22
protects nonhuman22
virus neutralization22
toremifene citrate21
performed using21
exporting country21
i ifns21
ebola viral21
african green21
mediated cell21
blood ebov21
trvlp infection21
human transmission21
vaccine protects21
lassa virus21
protein expression21
marv infection21
virus input21
present study21
well plates21
spectrum antiviral21
mediated fusion21
experimentally infected21
therapeutic agents21
flow cytometry21
entry requires21
human travel21
disease outbreaks21
immunosorbent assay21
prime boost20
zika virus20
drnpc domain20
entry mediated20
replication cycle20
heptad repeat20
tetherin expression20
cells via20
molecular dynamics20
fatality rates20
clinical signs20
time point20
yellow fever20
sequence alignment20
weight loss20
endoplasmic reticulum20
peripheral blood20
myeloid cells20
transporter niemann20
competing interests20
disease control20
time points20
risk factors20
protective efficacy20
cathepsin activity20
bovine serum20
per well20
creative commons20
evd survivors20
transmembrane domain20
small molecules20
directional changes19
immune evasion19
dependent manner19
transfected cells19
helix bundle19
late endosomes19
samples collected19
inflammatory responses19
cleavage site19
ebov mak19
proinflammatory cytokines19
encephalitis virus19
primary human19
emerging infectious19
molecule inhibitors19
based assay19
furin cleavage19
supplementary material19
life technologies19
cell viability19
emerging viral19
gp expression19
luciferase reporter19
days post19
adaptive immune19
family filoviridae19
specific antibodies19
plate reader19
crystal structure19
supportive care19
branch lengths18
infected mice18
human ebov18
host factors18
natural reservoir18
single dose18
postexposure protection18
plasmids encoding18
based assays18
passive transfer18
cytokine dysregulation18
results suggest18
commonly used18
tissue culture18
log tcid18
endosomal membrane18
necrosis factor18
type lectin18
viral membrane18
kcal mol18
viral pathogens18
tissue factor18
rna interference18
infection ebola18
vaccinia virus18
clinical features18
fda approved18
envelope glycoproteins18
three times18
like receptor18
immune activation18
ebov vlps18
protein kinase18
central africa18
south korea17
signaling pathways17
neutralisation assay17
gp subunit17
severe disease17
com scientificreports17
reverse genetics17
ebov challenge17
pseudotyped vsv17
nile virus17
adverse events17
rhesus macaque17
secondary structure17
significant difference17
cleaved gp17
structural proteins17
ebov activity17
positive selection17
ebov genomes17
human infections17
final concentration17
microfluidic cartridge17
gp furin17
cell lysates17
ri rna17
elevated levels17
virus vaccine17
plasma samples17
west nile17
mpxv infection17
human survivor17
conformational changes17
respiratory syncytial16
reservoir hosts16
exposure treatment16
ebola infection16
virus neutralisation16
data set16
lassa fever16
syncytial virus16
cell activation16
target cell16
type lectins16
gxxxg motif16
least one16
ebov neutralisation16
information regarding16
tumor necrosis16
hemorrhagic fevers16
reston virus16
fusion pore16
human macrophages16
ic values16
emerging viruses16
reston ebolavirus16
hspa motif16
family members16
ebov rna16
filovirus glycoproteins16
recombinant vsv16
viral loads16
cell cultures16
envelope protein16
lake victoria16
human ebola16
three areas16
kinase inhibitors16
mediated protection16
green monkey16
molecular mechanisms15
lymphoid tissues15
humoral immunity15
intravascular coagulation15
folate receptor15
nucleocapsid proteins15
march proteins15
gp gene15
rna editing15
antigen presentation15
restriction factor15
extracellular vesicles15
african outbreak15
ebov disease15
virus strains15
control group15
small animal15
lethal infection15
expression plasmid15
single particle15
equine encephalitis15
rna genome15
cell signaling15
substitution rates15
endothelial cell15
filoviridae family15
isg induction15
secondary antibody15
recent years15
authors declare15
binding affinity15
virus envelope15
plaque assay15
previously reported15
cells expressing15
bodily fluids15
neutralization assay15
african ebola15
ebolavirus infection15
cysteine proteases15
significantly higher15
filovirus infections15
fatal cases15
virus vaccines15
vero cells15
african countries15
neutralisation assays15
survival rate15
single amino15
legal trade15
lethal dose15
insect cells15
disease onset15
entry inhibitors15
spike protein15
ebola treatment14
surface protein14
vaccine vectors14
recombinant human14
length gp14
side effects14
fetal bovine14
ebola zaire14
valley fever14
inhibitors reveal14
ebov makona14
high degree14
specific antibody14
gp mrna14
rift valley14
goat anti14
transcriptional editing14
disease outbreak14
ebov negative14
great ape14
saharan africa14
glycoprotein bound14
vectors expressing14
internal branches14
jui government14
ebola epidemic14
protective immunity14
copies ml14
filovirus gp14
sudan ebola14
infected nhps14
even though14
ebov igg14
animal studies14
reveal niemann14
virus detection14
serum panel14
npc binding14
may provide14
virus ebola14
mhc class14
clinical manifestations14
generation sequencing14
dna vaccine14
min ph14
recent studies14
fused scfv14
tcid ml14
vp proteins14
recent outbreak14
forming units14
infection control14
gp contains14
buffered saline14
body fluids14
control antigen13
i interferons13
protective equipment13
virus isolation13
lymph nodes13
ng pcaggs13
host responses13
substitution models13
pathogenic avian13
new world13
acid residues13
sequence analysis13
experimental infection13
three different13
internal fusion13
different cell13
victoria marburgvirus13
swab samples13
wild type13
whole blood13
mammalian cells13
rna secondary13
multiorgan failure13
directional change13
human disease13
expressing ebola13
saudi arabia13
entry receptor13
evd survivor13
causative agent13
theraflex mb13
inhibit ebov13
human tetherin13
taken together13
determine whether13
image analysis13
currently available13
endosomal proteolysis13
culture medium13
neutralizing activity13
disseminated intravascular13
inhibit ebola13
gp proteins13
multiple sequence13
congo basin13
government hospital13
lymphocyte apoptosis13
experimental ebola13
secondary structures13
human evd13
increased risk13
cov outbreak13
sense rna13
transcription factor13
including ebov13
expression vector13
response curves13
convalescent plasma13
cellular responses13
without vlps13
clinical management13
higher levels13
epithelial cells13
cell immunoglobulin13
ebov virus13
humoral immune13
great apes13
host proteins13
infected individuals12
genbank accession12
cleaved ebov12
nucleoside analogues12
late endosomal12
dromedary camels12
particle release12
current study12
raw product12
three independent12
ph pulse12
web server12
virus shedding12
abdominal pain12
ah conditions12
mers coronavirus12
mortality rates12
vaccine expressing12
viral dissemination12
positive control12
human dendritic12
serial dilutions12
detected using12
exposure protection12
large number12
virus nucleoprotein12
egyptian fruit12
cell membrane12
polymerase chain12
branch length12
authentic ebov12
intracellular receptor12
healthy adults12
thermofisher scientific12
gfp minigenome12
dna sequences12
may result12
nh cl12
hong kong12
measured using12
high viral12
confirmed cases12
ebolavirus vp12
dna vaccines12
years ago12
eu mss12
chain reaction12
ebola vaccines12
surface hspa12
mva ebov12
plasmacytoid dendritic12
data indicate12
commons license12
common marmoset12
simian immunodeficiency12
conformational change12
cell immunity12
viral glycoproteins12
primate models12
pick type12
drug administration12
also showed12
endosomal cathepsins12
low levels12
post infection12
clomiphene citrate12
mortality rate12
vsv pseudotypes12
drug target12
personal protective12
negative serum12
nucleic acids12
controlled trial12
genome replication12
graphpad prism12
evd outbreaks12
venezuelan equine12
virus nucleocapsid12
virus titers12
log reduction12
i clinical12
national institutes12
bearing ebov12
central african12
fatal disease12
cell cytoplasm12
disease ebola12
ebov vaccine12
terminal heptad12
thermolysin treatment11
quantified using11
recombinant adenovirus11
post transfection11
entry driven11
sodium dodecyl11
throughput screening11
dependent enhancement11
ebov strains11
zaire strain11
adapted ebov11
clinical data11
regulatory factor11
one study11
gel electrophoresis11
mononuclear cells11
disease progression11
virus enters11
coagulation abnormalities11
surviving patients11
phylogenetic analysis11
broad range11
protein interactions11
ebov lifecycle11
likely due11
day post11
cohort study11
healthcare workers11
enveloped virus11
eidolon helvum11
patients infected11
different ebov11
decreasing trend11
pseudotypes bearing11
within days11
animal species11
nhp model11
transferrin receptor11
host response11
ebov np11
cell layer11
binding protein11
disease surveillance11
late endosome11
polymerase cofactor11
rate variation11
presenting cells11
vaccinated mice11
hydrogen bond11
pbs group11
day postexposure11
nucleoside analogs11
convalescent patients11
neutral ph11
strand rna11
protein sequences11
antiviral activities11
therapeutic antisera11
postexposure prophylaxis11
human antibody11
using pseudotyped11
electron tomography11
mb light11
iav ha11
introduction event11
ebov fusion11
preliminary report11
proposed epitope11
virus specific11
existing immunity11
based ebola11
bat species11
virus genomes11
sudan virus11
cell tropism11
advanced ebola11
infectious virus11
specific igg11
expression levels11
tnc substitutions11
ebolavirus species11
ebov particles11
influenza vaccine11
respiratory disease11
associated proteins11
fusion events11
substitution model11
encoding ebov11
first time11
direct contact11
virion glycoproteins11
error bars11
imported case11
national institute11
correlation coefficients11
nonendemic countries11
inflammatory cytokines11
successful treatment11
heavily glycosylated11
fusion pores11
np i11
tetherin counteraction11
inflammatory response11
two different11
laboratory studies11
adaptive immunity11
soluble gp11
viral life11
lectins dc10
serum panels10
inhibition assay10
igg antibody10
host endosomal10
recent study10
also used10
mev rpv10
viral genomes10
mouse igg10
confirmed evd10
binding free10
novel coronavirus10
kinome analysis10
peptide arrays10
infection resulted10
nucleotide substitution10
different viruses10
strains isolated10
acute infection10
clinical presentation10
high mortality10
cytoplasmic tail10
software package10
independent experiments10
molecular basis10
expression vectors10
functional analysis10
egyptian rousettes10
regression analysis10
infected cynomolgus10
marv entry10
open reading10
treated animals10
via macropinocytosis10
total antibody10
also found10
statistical analysis10
specific cd10
cellular immunity10
ebov epidemic10
cleaved form10
contact tracing10
viral transcription10
rpv pprv10
sigma adjuvant10
medium containing10
tetherin antagonist10
vaccine platforms10
ebov spread10
luciferase signal10
genome sequencing10
inhibitory activity10
sustained targets10
cellular membranes10
initial viral10
cell response10
fused scfvs10
potential therapeutic10
leukemia virus10
well plate10
inhibit filovirus10
estrogen receptor10
ebola outbreaks10
acid residue10
open access10
repeat region10
cell type10
clinical observations10
receptor niemann10
reading frame10
genomic surveillance10
ctl vaccine10
way anova10
fusion induced10
bundibugyo ebolavirus10
human papillomavirus10
confocal microscopy10
evd cases10
epitope prediction10
alpha beta10
makona variant10
vp may10
culture supernatant10
virus fusion10
global health10
cell death10
dce sum10
platelet concentrates10
patients treated10
fever viruses10
antiviral effects10
therapeutic targets10
wt mice10
interferon response10
reproductive tract10
free energy10
cellular membrane10
vaccine efficacy10
monkey kidney10
infected cell10
reading frames10
acidic ph10
structural basis10
particles produced10
ebov isolate10
eu ms10
genomic rna10
treatment group10
decay rates10
humoral responses10
tyrosine kinase10
antiviral response10
expressing ebov10
also shown10
significant differences10
common features10
gp sequences10
standard error10
cationic amphiphiles10
direct effect10
viral diseases10
serum samples10
statistical significance10
virus density10
endemic areas10
cell receptor10
primate model10
cathepsin cleavage10
antibodies directed10
virus persistence10
substitutions site10
expressing cells10
ebov proteins10
endosomal membranes10
host protein10
functional characterization9
plasma concentrations9
activated protein9
united kingdom9
proteolytic cleavage9
respiratory distress9
horseradish peroxidase9
ebov minigenome9
shock protein9
stably expressing9
endocytic pathway9
average number9
converting enzyme9
human fatal9
early stages9
aberrant innate9
asymptomatic ebola9
first months9
virus particle9
virus prevalence9
mediate cellular9
flag antibody9
fibrin deposition9
shed gp9
blood transfusions9
ebov trailer9
mm tris9
human macrophage9
rapid diagnosis9
boost vaccination9
whether ebov9
wild great9
significantly reduced9
virus matrix9
virus origin9
high dose9
european union9
total number9
geometric mean9
surveillance elucidates9
dynamics simulation9
human monocytes9
ring vaccination9
distinct mechanisms9
factor viia9
ebola patients9
rna binding9
ebola glycoprotein9
natural host9
cells treated9
macaque model9
chimpanzee adenovirus9
pandemic influenza9
ebov viral9
ifn induction9
disease severity9
situation report9
big data9
mediated immune9
selective estrogen9
supplementary data9
recombinant nematode9
fusion mediated9
passive immunization9
complex formation9
endosomal acidification9
lineage dual9
discovery studio9
massive lymphocyte9
ebov vlp9
expression plasmids9
ebola response9
derived dendritic9
symptom onset9
viral titers9
penicillin streptomycin9
membrane protein9
closely related9
within endosomes9
md simulations9
filovirus family9
aegyptiacus bats9
may play9
channel blocker9
ad vaccine9
virus proteins9
plasmid encoding9
gp gp9
viral vectors9
elisa plates9
pbs containing9
data analysis9
mediated endocytosis9
blood mononuclear9
mayinga strain9
therapeutic efficacy9
important factor9
virus infectivity9
chikungunya virus9
inhibitory concentration9
filoviral entry9
filoviral hemorrhagic9
affected countries9
using recombinant9
plasma levels9
international scientific9
molecular weight9
infectious agents9
substitution rate9
ebov trvlp9
using different9
takes place9
commercially available9
modified vaccinia9
current outbreak9
nucleocapsid protein9
proinflammatory cytokine9
recombinant ebov9
transfection reagent9
i fusion9
morpholino oligomers9
south africa9
external solution9
elucidates ebola9
disease epidemiology9
mechanical ventilation9
antiviral immunity9
early stage9
vsv vectors9
van der9
cellular proteins9
safety profile9
calcium channel9
three subtypes9
total rna9
fold higher9
binding pocket9
cellular receptors9
mediated restriction9
cleave ebov9
endosomal proteases9
cells infected9
weeks post9
common feature9
metagenomic sequencing9
deficient mice9
binding sites9
virus spread9
dependent protein9
total gp9
receptor modulators9
der waals9
mpxv infections9
critical role9
results indicate9
turned negative9
ct values9
virus genome9
post disease9
gp processing9
like structures9
poorly understood9
viral disease9
attenuated recombinant9
passive microfluidic9
emerging infections9
neutralizing monoclonal9
sucrose cushion9
fever ebola9
phage display9
dodecyl sulfate9
human antibodies9
theraflex uv9
virus load9
live virus9
vascular permeability9
care workers9
may reflect8
virus polymerase8
length ebov8
tested positive8
antibody kz8
drug targets8
i studies8
virus rna8
drug resistance8
dependent inhibition8
replication promoter8
two weeks8
needle stick8
npc orthologs8
ec values8
functional antibody8
described elsewhere8
ebov may8
data suggest8
lesser extent8
human march8
postexposure antibody8
antibody immobilization8
protein sequence8
antigenic protein8
marburg haemorrhagic8
regulatory approval8
health response8
acid changes8
commons attribution8
multiple cell8
dynamics simulations8
crystal structures8
receptor alpha8
ready form8
molecular docking8
drug discovery8
vivo studies8
bars indicate8
outbreak setting8
suspected cases8
greatly reduced8
ribonucleoprotein complex8
content imaging8
readily available8
supplementary table8
ill patients8
filoviral gp8
cell lysate8
determined using8
severe covid8
log day8
filovirus cell8
anticoagulant protein8
neutralizing human8
endo lysosomal8
selective pressure8
therapeutic approaches8
igy antibodies8
one outbreak8
monocytes macrophages8
phase iii8
expression system8
acute phase8
recovery process8
viruses ebola8
dcs may8
eahy cells8
africa ebola8
clinical studies8
findings suggest8
gp protein8
bat populations8
treatment center8
ebov antibody8
experimental inoculation8
fluorescent protein8
cells transfected8
sudv gp8
bat npc8
also observed8
neutralising antibodies8
graphpad software8
viral data8
fps sum8
host membrane8
renilla luciferase8
mouse models8
cell system8
pathogenic viruses8
murine leukemia8
western african8
heat shock8
cellular targets8
culture supernatants8
african evd8
ebov species8
previous work8
gp cleavage8
technical committee8
human monoclonal8
protect nonhuman8
viral haemorrhagic8
different species8
growth factor8
genome sequence8
sequence data8
mechanisms underlying8
kindly provided8
nns rna8
live animal8
human igg8
nitric oxide8
antibody titres8
similar results8
virus surface8
will require8
also demonstrated8
type calcium8
previous study8
molecular events8
fatal outcome8
chain termination8
acid sequences8
congo hemorrhagic8
molecular dating8
antibody prophylaxis8
endosomal lysosomal8
gene inhibition8
gp alone8
dimensional structure8
provide protection8
polyacrylamide gel8
us department8
clinical presentations8
vaccine candidate8
fatal zaire8
given ip8
normal distribution8
one year8
bats may8
full text8
nematode anticoagulant8
gb virus8
infected marmosets8
green monkeys8
endosomal cysteine8
ge healthcare8
cos cells8
reduced ebov8
medical countermeasures8
animals infected8
mem medium8
inhibitory effect8
highly immunogenic8
single nucleotide8
increasing amounts8
green fluorescent8
supplemental table8
molecular mechanism8
disease virus8
block ebov8
common among8
pregnant women8
clinical symptoms8
seven genes8
least two8
iris chip8
lymph node8
kinome peptide8
ebolavirus disease8
also detected8
higher doses8
ebov transmission8
forward projections8
viia tissue8
data presented8
north america8
endosomal receptor8
npc gene8
provides protection8
nucleoside analogue8
lassa viruses8
distress syndrome8
cells using8
cellular cholesterol8
another important8
viral antigens8
monkeypox virus8
human populations8
antibody prevalence8
gp fusion8
interferon signaling8
interferon regulatory8
cells stably8
high sensitivity8
firefly luciferase8
genetically diverse8
acid amplification8
human asymptomatic8
viral gp8
measles virus8
mouse anti8
evidence suggests8
previous reports8
human population7
antigen capture7
passive immunotherapy7
borne viruses7
hiv gag7
positive patients7
ammonium sulfate7
cho cells7
clinically approved7
mutation rate7
lethal disease7
seasonal pulses7
potent neutralizing7
fold serial7
respiratory symptoms7
response team7
environmental conditions7
gp residues7
remains neutral7
directly immobilized7
igg responses7
via siglec7
two groups7
current epidemic7
respiratory failure7
protein gp7
different strategies7
calcium channels7
virus nonstructural7
first immunization7
mutant lxxxl7
np protein7
surface accessibility7
host species7
point mutations7
recombinant vp7
marburg agent7
another study7
vp interaction7
scfv format7
vsv particles7
short stretches7
cell binding7
stomatitis viruses7
sialic acid7
clinical illness7
sequencing data7
severe sepsis7
body weight7
hospitalized patients7
neutralization assays7
proprotein convertase7
patient viral7
ebov infects7
small interfering7
test whether7
quality control7
protective effect7
recombinant protein7
important step7
outbreak response7
igg ebov7
virus binding7
enters host7
pcr primers7
gilead sciences7
beta turn7
also inhibited7
tyro family7
cellular immune7
common directional7
oral swab7
control measures7
ongoing outbreak7
reactive oxygen7
twice daily7
dye spread7
conserved region7
mediated immunity7
recently shown7
secondary lymphoid7
fei company7
jurisdictional claims7
analyses showed7
word count7
infectious dose7
thank dr7
coronavirus infection7
directed mutagenesis7
antiviral host7
mm nacl7
transmission events7
silico docking7
basin mpxv7
binding energy7
inhibitors targeting7
mice vaccinated7
peptide binding7
respiratory viruses7
rabies virus7
vp binding7
kda gp7
flow cartridge7
aids reagent7
past outbreaks7
supplementary file7
inner leaflet7
higher ah7
features pharmacophore7
human patients7
interferon responses7
standard deviations7
human activated7
co incubator7
viral mutation7
golgi apparatus7
detection limit7
coding regions7
standard deviation7
died within7
assay using7
cytopathic effect7
terminal domain7
infect cells7
treatment regimen7
vsv spread7
study demonstrated7
mice treated7
current ebola7
recombinant vaccine7
acid change7
phase trial7
entry inhibitor7
positive serum7
clinical research7
infection results7
counteract tetherin7
case scenario7
specific activity7
previously shown7
forest virus7
using lipofectamine7
receiver operating7
fatal human7
np antibodies7
published maps7
go soluble7
sign mediate7
studies using7
dpi survived7
ocular fluid7
antibody levels7
helvum npc7
transmission dynamics7
may occur7
per milliliter7
fatal evd7
kj mol7
virus life7
rabbit sera7
purification process7
cd cells7
severe ebola7
much lower7
cynomolgus monkeys7
clinical development7
virus circulation7
active metabolite7
lipid bilayer7
therapeutic strategies7
human influenza7
lower respiratory7
human cell7
fresh medium7
dose vaccination7
dependent entry7
scoring function7
molecular biology7
serological assays7
polymerase complex7
prophylaxis protects7
bombali virus7
viruses using7
broad antiviral7
viper npc7
filoviral infection7
current knowledge7
fps es7
persistent infection7
fusion peptide7
macaques infected7
metabolite deaq7
visualized using7
sl reference7
reduced fusion7
hsnpc domain7
ebolavirus antibodies7
increased vascular7
intracellular compartments7
ligand pharmacophores7
two reading7
five different7
secondary cases7
nature remains7
ifn response7
membrane proteins7
three viral7
vlp release7
disease patients7
use authorization7
entry via7
infectious ebov7
fold dilutions7
infection may7
absolute humidity7
viral shedding7
results demonstrate7
antiviral strategies7
vectored vaccine7
viruses doi7
filovirus vaccine7
callithrix jacchus7
diverse marburg7
inhibit viral7
ifn antagonism7
proinflammatory responses7
vp scfvs7
different strains7
series changes7
i binding7
post onset7
nucleoside analog7
based vectors7
zoonotic rna7
viral antigen7
infected nonhuman7
antibody cocktail7
chronic diseases7
zoonotic viruses7
molecular evidence7
institutional affiliations7
signal intensity7
study team7
past years7
factor tetherin7
human serum7
previous outbreaks7
docking simulation7
marv replication7
permissive cells7
ifn responses7
investigate whether7
blocks ebov7
several different7
ebov using7
vaccine platform7
intensive care7
gold standard7
nhp models7
wild animal7
antiviral responses7
will discuss7
methylene blue7
viral clearance7
serological survey7
gp subunits7
virus growth7
vp forms7
acid sequence7
based substitution7
spillover events7
ebov outbreaks7
surface gp7
deficient cell7
ebola vp7
expressing phage7
control mice7
recombinant inhibitor7
molecule inhibitor7
direct antiviral7
conservancy analysis7
accession number7
african mpxv7
igg antibodies7
fatal outcomes7
specific monoclonal7
ebola situation7
travel history7
loading dose7
genetic material7
transmission chains7
negative regulatory7
soluble mediators7
barrier function7
world arenavirus7
restriction sites7
reagent program7
sense single7
candidate vaccines7
humans infected7
calculated using7
septic shock7
lung pathogenesis7
vaccines based7
significantly different7
erk mapk7
pediatric patients7
antiviral agents7
induced transmembrane7
ebov patients7
polymerase inhibitor7
experimental testing7
dna spots7
clustered together7
virus genomic7
viral nucleoprotein7
gp structure7
dsrna binding7
transmembrane proteins7
rnp complex7
cells well7
egyptian rousette7
nucleocapsid formation7
frequently used7
surface proteins7
drug screen7
springer nature7
specific binding7
severe hemorrhagic7
coiled coil7
retinoic acid6
force field6
health measures6
hypsignathus monstrosus6
vectors encoding6
may affect6
luciferase assay6
tai forest6
interferon antagonism6
clinical samples6
jsrv env6
long oligonucleotides6
mm mgcl6
efficient entry6
induced cytolysis6
bats coincide6
evolutionary dynamics6
genome length6
nuclear import6
effectively neutralized6
either ebov6
ebov attachment6
mediated tetherin6
cathepsin inhibitors6
three human6
phase ii6
virus antigen6
natural hosts6
available data6
also known6
glycoprotein sgp6
calcium phosphate6
ebov nucleocapsid6
mrna stability6
chest pain6
viral receptor6
vlp treatment6
small soluble6
mutations within6
pcr products6
adjuvanted ebov6
macaque models6
wt gp6
fluorescent assay6
antibody produced6
cell pairs6
infectious pathogens6
adjuvanted microsphere6
bat genomes6
human embryonic6
male reproductive6
expressing hafl6
much higher6
isothermal amplification6
culture media6
cholesterol clearance6
sequence similarity6
data collected6
weeks later6
adult patients6
ebov detection6
intramuscular injection6
dual model6
median age6
virus assays6
solved structure6
gp binding6
viral elements6
stimulated genes6
fresh growth6
libdock scores6
th century6
patients may6
expressing marv6
one introduction6
viral genes6
randomized controlled6
junin virus6
decay rate6
histocompatibility complex6
mice without6
infectious ebola6
high level6
homogeneous assay6
tetherin inhibits6
natural history6
plasmodium falciparum6
hla molecule6
gp antibodies6
expressing phages6
antibody binding6
epitope identification6
may contribute6
hydrophobic residues6
live attenuated6
natural human6
combination therapy6
human outbreaks6
march inhibits6
adenovirus serotype6
prolongs survival6
plos one6
protect mice6
liver enzymes6
small glycoprotein6
africa outbreak6
data obtained6
animal origin6
two distinct6
direct exposure6
pore formation6
care worker6
phosphorodiamidate morpholino6
macropinocytic pathway6
human pathogens6
glycosylated mucin6
virus strain6
therapy prolongs6
multiple cationic6
positive results6
syndrome virus6
nonstructural small6
promising candidates6
nonporous surfaces6
march expression6
virus families6
hiv gp6
virus densities6
vaccine effectiveness6
evolutionary rate6
induce fusion6
sequence changes6
cancer therapy6
kind gift6
laboratory diagnosis6
covalent modifications6
tested negative6
human clinical6
virus vector6
experimental infections6
mediated entry6
chemokine expression6
modulators inhibit6
fps vdw6
coomassie blue6
viral persistence6
new insights6
primary antibody6
ebov antibodies6
viral genomic6
received vlps6
available therapeutic6
highly divergent6
virus sample6
causes lethal6
treatment options6
infected humans6
close contact6
ebov persistence6
ebov survivors6
structural integrity6
conjugated secondary6
obtained using6
ravv ravn6
nk cells6
transmembrane protein6
bacterial translocation6
major histocompatibility6
minigenome assay6
ebolavirus challenge6
peer review6
type virus6
potential threat6
similar dose6
genomic replication6
virus makona6
precursor gp6
first reported6
surface glycoprotein6
clinical efficacy6
enhance infection6
entry pathway6
potential targets6
associated coronavirus6
basic amino6
immunosorbent assays6
grand island6
infection status6
virus reduction6
diagnostic tests6
active form6
genus ebolavirus6
exporting countries6
antigen expression6
pig model6
completely protects6
ic value6
high case6
phylogenetic tree6
embryonic kidney6
bacteriophage phi6
phase clinical6
deleted ebov6
ucsf chimera6
hemorrhagic manifestations6
recombinant ad6
filovirus receptor6
virus outbreaks6
march blocks6
akt mtor6
fever outbreak6
mtor signaling6
outbreak scenarios6
virus variants6
interferon system6
virus assembly6
interim analysis6
protect guinea6
two independent6
multivariate analyses6
infection prevention6
previously identified6
vp inhibits6
image processing6
fda drugs6
fresh culture6
assay conditions6
hyperimmune sera6
viruses may6
relative importance6
research facility6
blot analysis6
filovirus species6
clomiphene blocks6
lectin specific6
ml rvsv6
genetic diversity6
average virus6
purified igg6
cytopathic effects6
systematic review6
virus vectors6
study showed6
mediated viral6
log pfu6
effective antiviral6
additional days6
analyzed using6
affinity chromatography6
rnp formation6
series word6
infected pigs6
also tested6
also contribute6
ring domain6
molecular characterization6
large outbreaks6
directed expression6
short stretch6
epitope conservancy6
different assays6
luminal domain6
approved selective6
extracellular vesicle6
worst case6
specific parameters6
pcr confirmed6
lethal experimental6
virus structure6
infected guinea6
key residues6
endemic countries6
total protein6
phi may6
convertase furin6
fusion form6
peptide sequence6
postexposure treatment6
pathogen reduction6
among patients6
healthcare life6
cell targeting6
ebov rt6
filovirus host6
serum levels6
entry factor6
risk analysis6
mediated isothermal6
per group6
protein data6
biological weapons6
animal care6
data bank6
pump inhibitors6
convalescent sera6
ifn antagonist6
biochemical analysis6
leone ebola6
pick disease6
highly lethal6
currently circulating6
proteases cathepsin6
conjugated goat6
person transmission6
serum dilution6
kidney cells6
relatively high6
conditions tested6
life sciences6
remains unclear6
ebov exposure6
antiviral drug6
potently neutralizing6
fold greater6
haemorrhagic fevers6
small nonhuman6
mononucleotide composition6
natural infection6
gabonese bat6
oxygen species6
survival rates6
arms races6
pseudotype viruses6
targeting gp6
mean time6
ebov variant6
leader panhandle6
least three6
outbreak strain6
protects guinea6
newly discovered6
endosomal pathway6
adenovirus vectors6
done using6
scientificreports www6
inducible gene6
human survivors6
strong inflammatory6
screening assay6
helical nucleocapsid6
disease outcome6
ph dependence6
recent report6
axl enhances6
productively infected6
lipid raft6
coronavirus disease6
infection via6
ns protein6
significantly lower6
mutational analysis6
sensor surface6
posttranslational modification6
inhibit hiv6
activated dcs6
protein interaction6
vp expression6
human npc6
integrated research6
bundibugyo virus6
rna silencing6
risk assessment6
human mpxv6
molecule entry6
mediated phosphorylation6
visible light6
available online6
tetherin bst6
stabilized matrix6
oligonucleotide composition6
phase trials6
verapamil inhibit6
mediate viral6
viruses causing6
highest probability6
another approach6
accidental exposure6
cocktail antibodies6
particle formation6
ebov igy6
human filovirus6
alexa fluor6
favorable interactions6
african fruit6
infected rhesus6
juvenile rousettus6
go scfv6
average weight6
second luminal6
mature dendritic6
kinome data6
reduce viral6
protective monotherapy6
vsv infection6
laboratory animal6
endogenous viral6
gp shedding6
computational analysis6
using two6
rna interactions6
immunized intramuscularly6
serum albumin6
breast cancer6
liver function6
particles containing6
immune mediators6
virus polymerases6
viral release6
novel therapeutic6
minigenome system6
strain mayinga6
vp blocks6
genomic analysis6
online version6
infected monocytes6
rinderpest virus6
matrix proteins6
breast milk6
nucleotide variations6
productive infection6
convalescent blood6
animal mortality6
diagnostic performance6
chronic hepatitis6
surface glycoproteins6
approved drug6
employ different6
disease symptoms6
like phenotype6
may lead6
new ebola6
pathogen inactivation6
relative humidity6
antibody titer5
rna polymerases5
shown previously5
novel broad5
based analyses5
genomic sequencing5
observational study5
luciferase activity5
interferon production5
broad spectrum5
diagnostic assays5
dc subsets5
vaccines protect5
purified equine5
protect nhps5
antiviral factor5
glycosylated gp5
sera collected5
cellular factors5
significance level5
ebola rna5
evolutionary history5
receptor activity5
buffered formalin5
hepatic lesions5
antibody fails5
efficient growth5
coding region5
transfection medium5
relatively short5
viruses replicate5
cytotoxic effects5
analogue bcx5
endosomal ph5
visit http5
santa cruz5
two major5
tmrca estimates5
ape populations5
nucleotide changes5
amphiphiles induce5
multiple ebola5
extensive intravascular5
human anti5
reverse transcriptase5
tetherin restriction5
highly glycosylated5
lung tissue5
sporadic outbreaks5
many viruses5
threshold values5
analysis using5
three mabs5
cell factors5
antigen presenting5
may influence5
hydrophobic interactions5
ebov dissemination5
asialoglycoprotein receptor5
reservoir host5
glycoprotein expressed5
test sera5
virus marburg5
ebov pathogenesis5
early treatment5
immune globulin5
underlying coagulation5
derived macrophages5
adenovirus vector5
cells might5
vlp injection5
greater fusion5
cells may5
pathogen recognition5
without inducing5
envelope proteins5
dna microarrays5
high yield5
epitope database5
solid substrates5
emerging diseases5
thermal stability5
neutralising activity5
pandemic potential5
sudv outbreak5
antiviral effectors5
gorilla fecal5
limited number5
viral infectivity5
block ebola5
antibody capture5
virus protein5
suspected evd5
derived monoclonal5
recent west5
kinase axl5
cover slips5
jac online5
pseudoparticles bearing5
old world5
human primate5
relatively small5
particles bearing5
ebov sample5
highly accurate5
virion incorporation5
four compounds5
clinical syndromes5
inhibits viral5
ddi technique5
wild apes5
arise independently5
unless otherwise5
drug development5
leader interaction5
stick injury5
significant inhibition5
ion channel5
indicated drug5
confidence interval5
key event5
different times5
san diego5
research institute5
one virus5
note springer5
linked glycosylation5
surface expression5
may contain5
relative ranking5
mediated cleavage5
preliminary data5
evd pathogenesis5
accessibility prediction5
promote fusion5
patient care5
human cytomegalovirus5
different time5
immune epitope5
particle image5
health issues5
dimethyl sulfoxide5
np oligomerization5
virus membrane5
interferon alpha5
growth medium5
candidate vaccine5
comparative analysis5
clinical care5
primarily via5
four hours5
randomly assigned5
pdb id5
viral sensing5
gp mediates5
viruses battle5
interfering rna5
phosphatidylserine receptors5
subunit vaccines5
northern blot5
contains supplementary5
agent disease5
tissue samples5
acceptable safety5
gp spikes5
assays used5
virus stocks5
beta interferon5
antiviral therapy5
loop structure5
ebola glycoproteins5
scientific reports5
tm domains5
sl ebov5
beta therapy5
well established5
washed three5
first step5
hydrophobic features5
recombinant antigen5
wag i5
potential vaccine5
fasman beta5
cells per5
protease inhibitors5
index case5
integrated density5
marv particles5
newly synthesized5
trvlp system5
core structure5
experimentally validated5
borne zoonotic5
fatal ebola5
secondary infections5
vectored vaccines5
thermo scientific5
four fda5
complete genome5
proton pump5
biological processes5
blood viral5
reduce ebov5
enhances macropinocytosis5
different steps5
shed active5
risk estimate5
mediated neutralization5
npc ortholog5
pcr assay5
class ii5
day course5
regression lines5
new cases5
high concentrations5
therapeutic oligonucleotides5
efficacy studies5
mva boost5
rvsv ebola5
fusion kinetics5
negative septicemia5
relative risk5
biological samples5
aerosol transmission5
convalescent ebola5
seven structural5
baseline model5
passage number5
lsectin interacts5
pv assays5
inflammatory mediators5
virus involves5
without vlp5
ebola gp5
based ebov5
several viruses5
largest outbreak5
mean hospitalization5
ongoing evd5
control serum5
concentrations used5
immune defense5
vp matrix5
will need5
viral growth5
secretory pathway5
antibody spots5
protein structures5
direct evidence5
later stages5
emini surface5
upregulates siglec5
virus survival5
intravascular apoptosis5
inhibitory domain5
additional file5
viral budding5
ebov zaire5
adenine analogues5
gp interaction5
days prior5
multiple comparison5
structure prediction5
linear epitope5
mouse antibody5
primate monocytes5
vsv expressing5
filoviral gps5
six animals5
promotes filovirus5
rate estimates5
atcc crl5
two years5
smaller form5
phi persisted5
persisted longer5
important factors5
washed times5
mathematical modeling5
sudan ebov5
studies indicate5
side chains5
suitable surrogate5
nipah viruses5
china friendship5
subunits gp5
fusion experiments5
nhps survived5
nuclear factor5
positive correlation5
induced disease5
ravn virus5
ebov trvlps5
test values5
antibody treatment5
filovirus pathogenesis5
per dose5
asymptomatic infection5
atcc ccl5
health emergency5
vlp preparations5
based pseudotyped5
immobilization step5
vp virus5
glycoproteins enhances5
high prevalence5
binding assays5
concept study5
elisa using5
glycoprotein counteracts5
viral nucleocapsid5
emerging viraly5
defective recombinant5
disease treatment5
ebov transduction5
may shed5
may indicate5
electronic supplementary5
tumor virus5
egg yolk5
arabian peninsula5
human respiratory5
may represent5
safety data5
case management5
virtual screening5
blood urea5
virus decay5
conserved among5
naturally infected5
reporter vlps5
receptor npc5
footprint similarity5
safety concerns5
binding buffer5
gene assay5
fever associated5
rapid detection5
final volume5
ebov itu5
female mice5
hamster model5
authorized users5
tmprss expression5
type mice5
comprehensive analysis5
absorbent pad5
natural killer5
randomized trials5
collected blood5
inactivated ebov5
stainless steel5
vp structure5
complementary dna5
liver pathology5
experiments performed5
work suggests5
persistent ebov5
feature pharmacophore5
survival time5
disease epidemic5
virus amplification5
particle vaccine5
mobile laboratory5
serum proteins5
evd vaccine5
offered protection5
host adaptation5
newcastle disease5
different viral5
virus dissemination5
household contacts5
ccd camera5
test serum5
background level5
propensity score5
compassionate use5
linear regression5
using artificial5
may include5
proteins inhibit5
highly effective5
elapsed months5
effective treatment5
filovirus budding5
future work5
unpublished essential5
marv ci5
ebov via5
three species5
vp impairs5
geographic areas5