bigram

This is a table of type bigram and their frequencies. Use it to search & browse the list to learn more about your study carrel.

bigram	frequency
drug delivery	1014
drug discovery	576
clinical trials	571
side effects	445
drug repurposing	430
health care	396
mg kg	385
breast cancer	362
cancer cells	352
acute respiratory	336
respiratory syndrome	332
case report	325
kcal mol	305
amino acid	292
novel coronavirus	292
virtual screening	286
infectious diseases	284
outcome measures	283
main outcome	281
antiviral activity	277
adverse effects	266
public health	259
clinical trial	256
please specify	254
abstract type	254
severe acute	249
main protease	249
drug administration	248
drug development	244
lung cancer	239
drug repositioning	234
drug design	233
delivery systems	231
coronavirus disease	214
drug interactions	214
may also	210
immune response	209
drug release	205
drug resistance	204
approved drugs	204
growth factor	203
syndrome coronavirus	199
intravenous drip	198
cord uid	196
antiviral drugs	196
gene expression	196
doc id	196
epithelial cells	195
cell lines	191
virus infection	184
united states	181
delivery system	180
methods materials	168
molecular docking	168
viral infections	166
based drug	166
combination therapy	161
viral replication	160
respiratory tract	159
widely used	159
molecular weight	156
drug therapy	152
research abstract	151
abstract background	150
drug targets	149
natural products	149
activated charcoal	147
systematic review	139
rheumatoid arthritis	138
antiviral drug	135
adverse drug	135
clinical studies	134
active site	134
lymph nodes	134
risk factors	131
antimicrobial drugs	129
adverse events	129
drug candidates	128
carbon nanotubes	127
adsorption energy	127
protease inhibitors	127
cancer therapy	126
therapeutic agents	124
molecular dynamics	123
blood pressure	123
world health	122
anticancer drug	122
important role	122
drug reactions	121
animal models	121
lopinavir ritonavir	121
binding site	120
amino acids	120
cell culture	119
stem cells	119
antiviral agents	118
small molecules	118
drug use	117
virus replication	117
lung disease	116
commonly used	116
new drug	115
immune system	114
cell death	114
magnetic resonance	114
rna polymerase	114
intensive care	113
health organization	113
severe covid	112
clinical practice	112
acquired pneumonia	112
small intestine	110
patients treated	110
endothelial cells	110
clinical pharmacy	109
epidermal necrolysis	108
toxic epidermal	107
small molecule	107
crystal structure	106
immunodeficiency virus	106
binding affinity	105
converting enzyme	105
anticancer drugs	104
ebola virus	104
targeted delivery	104
laboratory animals	104
descriptive abstract	103
antimicrobial drug	103
influenza virus	103
potential drug	102
least one	102
nervous system	102
gene delivery	100
gastrointestinal tract	100
tumor cells	100
infected patients	100
drug binding	99
free energy	99
wide range	98
may occur	98
lung injury	98
cell line	98
middle east	98
imaging findings	98
viral infection	98
human immunodeficiency	97
medication reconciliation	97
east respiratory	97
drug combinations	97
pharmaceutical care	97
phase i	96
cystic fibrosis	96
clinical pharmacist	95
mg ml	95
matrix completion	94
new drugs	94
nmr spectroscopy	93
fda approved	92
heart failure	92
acid composition	92
respiratory distress	92
hydrogen bonds	92
protein binding	92
infectious disease	92
pulmonary fibrosis	91
phase ii	91
host cell	91
protein kinase	91
cell proliferation	91
drug molecules	90
cancer cell	90
renal failure	90
spike protein	90
gene therapy	90
binding sites	89
mean age	89
binding energy	88
energy gap	88
surface area	88
drug treatment	88
critically ill	87
protease inhibitor	87
dry powder	87
oxidative stress	87
resistant bacteria	87
oral administration	86
causative microorganisms	86
mouse model	86
hepatocellular carcinoma	86
monoclonal antibodies	85
present study	85
years old	84
control group	84
acid glycoprotein	84
leading edge	84
existing drugs	84
bone marrow	83
pediatric patients	82
hydrogen bond	82
central nervous	82
machine learning	82
sars coronavirus	81
cancer patients	80
mental health	80
serum albumin	80
broad spectrum	80
new york	80
patients receiving	79
particle size	79
epidermal growth	79
sjs ten	79
pulmonary disease	78
increased risk	78
cancer treatment	78
immune responses	78
therapeutic efficacy	78
spectrum antiviral	78
responsive systems	77
hiv aids	77
synthetic biology	77
electron microscopy	77
retrospective study	77
controlled trial	76
nucleic acids	76
mass spectrometry	76
ion channel	75
like protease	74
mg twice	74
may lead	74
university hospital	74
host cells	74
adverse reactions	74
mg day	73
lipid nanoparticles	73
associated pneumonia	73
plasma concentrations	73
outsourcing facilities	73
high doses	73
nucleic acid	73
cancer stem	73
distress syndrome	72
biomedical applications	72
pharmaceutical industry	72
recent years	72
infected cells	71
targeted drug	71
dependent rna	70
drug target	70
body weight	70
johnson syndrome	70
ill patients	70
drug interaction	69
author funder	69
pseudo amino	69
large number	69
herpes simplex	69
prostate cancer	69
granted medrxiv	69
hospitalized patients	68
medication adherence	68
commercially available	68
lupus erythematosus	68
zika virus	68
personalized medicine	68
blood vessels	68
may result	68
ng ml	68
cell types	68
even though	68
another study	67
solid lipid	67
sodium bicarbonate	67
per patient	67
cohort study	67
two different	67
aspiration pneumonia	67
recent advances	67
may cause	67
clinical use	67
human lung	66
care unit	66
health services	66
viral rna	66
deep learning	66
hiv infection	66
throughput screening	66
blood flow	66
primary care	65
emergency department	65
nitric oxide	65
dna damage	65
protein interaction	65
antimicrobial activity	65
controlled release	65
dendritic cells	64
viral load	64
lymph node	64
effective treatment	64
high risk	64
target cells	64
brain barrier	64
approved drug	64
observational study	64
type ii	64
treatment options	64
therapeutic options	64
renal function	63
factor receptor	63
recent study	63
type i	63
necrosis factor	63
respiratory diseases	62
related problems	62
computational methods	62
community pharmacies	62
copyright holder	62
protein expression	62
cell surface	62
medical devices	62
peer review	62
ion channels	62
chronic hepatitis	62
molecular mechanisms	62
peritoneal dialysis	61
type diabetes	61
salivary glands	61
drug courts	61
pediatric radiology	61
treat covid	61
lung diseases	61
healthy volunteers	61
case reports	61
drugs may	61
will also	61
also known	61
protein interactions	61
hybrid nanoparticles	61
randomized clinical	60
cell membrane	60
performed using	60
elderly patients	60
monoclonal antibody	60
binding free	60
mechanical ventilation	60
study group	59
computed tomography	59
liver disease	59
many cases	59
ncov sars	59
literature review	59
receptor antagonist	59
inflammatory drugs	59
total number	59
md simulation	59
recent studies	58
also reported	58
also used	58
drug screening	58
drug metabolism	58
heart disease	58
like particles	58
repurposable drugs	58
drugs used	58
potential drugs	58
different types	58
clinical pharmacists	58
differential diagnosis	58
statistically significant	58
pilot study	58
harm reduction	57
clinical outcomes	57
drug users	57
pregnant women	57
mortality rate	57
drug sales	57
phase iii	57
coronavirus infection	57
staphylococcus aureus	57
study showed	57
antiviral therapy	57
lung tissue	57
excess proton	57
oral delivery	57
animal model	56
pseudomonas aeruginosa	56
controlled drug	56
escherichia coli	56
fold higher	56
chemical structure	56
respiratory disease	56
cell lung	56
pulmonary drug	56
stem cell	56
ethylene glycol	56
tumor growth	56
binding pocket	56
polymeric nanoparticles	56
severe cases	56
new coronavirus	55
candidate drugs	55
drug reaction	55
plasma proteins	55
boron nitride	55
dengue virus	55
one patient	55
liver injury	55
also found	55
alveolar macrophages	54
disease progression	54
free drug	54
cov infection	54
intravenous injection	54
computational approaches	54
high throughput	54
community pharmacy	54
significant differences	54
prospective study	54
simplex virus	54
patient care	54
knowledge graph	54
mycobacterium tuberculosis	54
randomized controlled	54
patient safety	54
cellular uptake	54
colorectal cancer	53
drug products	53
gold nanoparticles	53
health professionals	53
dress dihs	53
rights reserved	53
resonance imaging	53
data sets	53
plasma membrane	53
kg times	52
high dose	52
long term	52
significantly higher	52
antibacterial activity	52
cancer drugs	52
several studies	52
substance use	52
potential therapeutic	52
antiretroviral therapy	52
reactive oxygen	52
potential inhibitors	52
solid tumors	52
drug absorption	52
two groups	52
host proteins	52
target interaction	51
previous studies	51
gastric cancer	51
pulmonary hypertension	51
uv light	51
virus type	51
therapeutic targets	51
two drugs	51
significant difference	51
ligand binding	51
medical device	51
innate immune	51
high affinity	51
hiv protease	51
clinical pharmacology	51
cell cultures	51
structural proteins	50
folic acid	50
active compounds	50
data analysis	50
human coronavirus	50
chronic obstructive	50
vivo studies	50
viral diseases	50
heart rate	50
antimicrobial agents	50
adverse effect	50
oral bioavailability	50
enzyme activity	50
md simulations	50
spinal cord	49
high levels	49
kidney disease	49
drug concentration	49
reverse transcriptase	49
crucial role	49
well known	49
traditional chinese	49
tumor necrosis	49
compassionate use	49
per day	49
metabolic acidosis	49
soft tissue	49
plasma protein	49
peripheral blood	49
signaling pathways	49
many drugs	49
calcium channel	49
cancer drug	49
lactic acid	48
tyrosine kinase	48
ray crystallography	48
drug shortages	48
systemic lupus	48
new therapeutic	48
patients received	48
viral proteins	48
cell cycle	48
inflammatory response	48
clinical characteristics	48
inhibitory activity	48
kinase inhibitor	48
results suggest	48
chloroquine phosphate	47
statistical analysis	47
among patients	47
human protein	47
clinical features	47
drug concentrations	47
human body	47
single dose	47
myocardial infarction	47
human serum	47
also observed	47
safety profile	47
human plasma	47
rats treated	47
wide variety	47
vitro studies	47
lymphatic system	47
qt prolongation	46
will discuss	46
medical center	46
gastric mucosa	46
iron oxide	46
molecular targets	46
adverse event	46
atrial fibrillation	46
sustained release	46
diabetes mellitus	46
drug hypersensitivity	46
inflammatory bowel	46
human health	46
significantly increased	46
also shown	46
kg day	46
antiviral agent	46
pulmonary delivery	46
cl pro	45
last years	45
care units	45
smooth muscle	45
endoplasmic reticulum	45
toxic effects	45
results showed	45
cell viability	45
pdb id	45
medical records	45
clinical symptoms	45
alkaline phosphatase	45
therapeutic drug	45
respiratory syncytial	45
data set	45
per year	45
chloroquine hydroxychloroquine	45
specific drug	45
human cell	45
higher risk	45
significantly reduced	45
valproic acid	44
target interactions	44
immune cells	44
transplant recipients	44
inhibitory effect	44
neural networks	44
syncytial virus	44
high concentrations	44
drug susceptibility	44
inflammatory cytokines	44
based approach	44
risk factor	44
oxygen species	44
plasmodium falciparum	44
van der	44
community pharmacists	43
three different	43
results obtained	43
relatively low	43
blood glucose	43
clinically relevant	43
health promotion	43
high level	43
effi cacy	43
cytokine storm	43
among others	43
ml min	43
radiation dose	43
authors declare	43
first time	43
physicochemical properties	43
neural network	43
obstructive pulmonary	43
ovarian cancer	43
findings suggest	43
well tolerated	43
antiviral effects	43
therapeutic effect	43
hydrogen bonding	42
cardiovascular disease	42
charge transfer	42
drug combination	42
steroidal anti	42
angiotensin ii	42
force field	42
many years	42
respiratory infectious	42
clinical data	42
antibiotic resistance	42
chronic diseases	42
fusion protein	42
drug loading	42
bowel disease	42
metastatic breast	42
kinase inhibitors	42
ex vivo	42
target proteins	42
binding protein	42
edge pseudopod	42
wound healing	42
data collection	42
medicinal chemistry	42
drug related	41
plasma concentration	41
study reported	41
intravenous administration	41
silver nanoparticles	41
vitro antiviral	41
toxicity studies	41
antimalarial drugs	41
room temperature	41
clinical efficacy	41
silico drug	41
upper respiratory	41
critical role	41
repurposed drugs	41
image quality	41
interstitial lung	41
million people	41
life cycle	41
significantly lower	41
antiviral activities	41
will provide	41
renal impairment	41
patients infected	41
acute lung	41
drug carrier	41
pulmonary tuberculosis	41
lymphoid tissue	40
drug effects	40
medrxiv preprint	40
interstitial pneumonia	40
anticancer activity	40
mg dl	40
viral entry	40
autoimmune diseases	40
low ph	40
naturally occurring	40
human disease	40
tract infections	40
lamina propria	40
past years	40
may provide	40
first step	40
one study	40
human cells	40
new insights	40
last decade	40
drug carriers	40
der waals	40
dose activated	40
pediatric population	40
fatty acid	40
pharmacy services	40
tumor cell	39
plant extracts	39
epithelial cell	39
pharmaceutical interventions	39
key role	39
allowed without	39
adult patients	39
sbt abpc	39
mr imaging	39
drug safety	39
flow cytometry	39
white matter	39
mechanical properties	39
without permission	39
estrogen receptor	39
small cell	39
better understanding	39
matrix factorization	39
pharmaceutical companies	39
mast cells	39
dynamics simulation	39
reuse allowed	39
alveolar damage	39
care providers	39
results indicate	39
natural product	39
polymeric nanocarriers	39
critical care	38
taken together	38
oral drug	38
dose adjustment	38
intestinal metaplasia	38
gene transfer	38
disease control	38
gi tract	38
currently available	38
low dose	38
goblet cells	38
urinary tract	38
corona virus	38
blood cells	38
signal transduction	38
low molecular	38
patients may	38
patients undergoing	38
transgenic mice	38
biological activity	38
protein structures	38
results show	38
diffuse alveolar	38
poster sessions	38
target protein	38
significant increase	37
controlled trials	37
based virtual	37
oral anticoagulants	37
animal studies	37
therapeutic potential	37
hiv drugs	37
contrast agents	37
york city	37
drug may	37
magnetic nanoparticles	37
drug supply	37
urgent need	37
antimicrobial peptides	37
may help	37
inflammatory diseases	37
pancreatic cancer	37
fold increase	37
small intestinal	37
sales data	37
angiotensin converting	37
negative bacteria	37
oxide nanoparticles	37
receptor blockers	37
general population	37
respiratory system	37
may require	37
binding domain	37
therapeutic drugs	37
pleural effusion	37
therapeutic strategies	36
potential targets	36
clinical development	36
tract infection	36
platelet aggregation	36
network pharmacology	36
treated patients	36
often used	36
puerto rico	36
nuclear magnetic	36
drug overdose	36
medicinal plants	36
two types	36
cardiovascular diseases	36
inhibitory effects	36
median age	36
functional groups	36
identify potential	36
helicobacter pylori	36
rna viruses	36
interstitial fibrosis	36
hypersensitivity reactions	36
acetylsalicylic acid	36
inclusion criteria	36
therapeutic target	35
coupled receptor	35
silico pharmacology	35
data suggest	35
drug monitoring	35
human primates	35
risk assessment	35
computational drug	35
structural basis	35
congenital heart	35
emergency use	35
virus entry	35
disulfide bond	35
twice daily	35
side effect	35
liver failure	35
protein synthesis	35
effective drug	35
high resolution	35
drug efficacy	35
drug resistant	35
inflammatory cells	35
early stages	35
plasma levels	35
rna virus	35
tumor microenvironment	35
drug response	35
salivary gland	35
nuclear receptors	35
chemotherapeutic agents	35
target site	35
wild type	35
weight loss	35
novel drug	35
responsive system	35
dependent manner	35
two main	35
potential treatment	34
clinical management	34
acid residues	34
discovery process	34
antitumor activity	34
systemic circulation	34
liver function	34
genetic variants	34
global health	34
rna synthesis	34
negatively charged	34
dose reduction	34
imaging features	34
based screening	34
natural compounds	34
chemical shift	34
transcription factor	34
respiratory failure	34
clinical applications	34
signaling pathway	34
made available	34
clinically approved	34
single cell	34
walled carbon	34
red blood	34
developing countries	34
hospital pharmacy	34
three times	34
use drugs	34
induced lung	34
previously described	34
inject drugs	34
care system	34
nursing home	34
supportive care	34
traditional medicine	34
clinically significant	33
molecular mechanism	33
human interactome	33
retrospective review	33
cell type	33
selected drugs	33
adrenergic receptor	33
chinese medicine	33
underlying disease	33
triple helix	33
polyethylene glycol	33
infl uence	33
supply chain	33
healthcare professionals	33
chemical structures	33
like proteinase	33
may increase	33
pharmacy department	33
human proteins	33
ace inhibitors	33
clinical presentation	33
crystal structures	33
drugs targeting	33
antiviral effect	33
two decades	33
graph regularized	33
drug sharing	33
potential antiviral	33
convalescent plasma	33
cell entry	33
health status	33
treating covid	32
drug allergy	32
hydrophobic interactions	32
membrane protein	32
artificial intelligence	32
biologically active	32
small bowel	32
potent inhibitor	32
protein data	32
american college	32
molecule inhibitors	32
respiratory infections	32
mrna expression	32
drug candidate	32
innate immunity	32
health insurance	32
coupled receptors	32
gastric lavage	32
synergistic effect	32
mouse models	32
disulfide bonds	32
successful treatment	32
internal medicine	32
transplant patients	32
also showed	32
ms ms	32
cutaneous adverse	32
many patients	32
clinical research	32
pharmacophore model	32
receptor binding	32
vascular endothelial	32
significant reduction	32
mesoporous silica	31
patients taking	31
loading dose	31
see table	31
current status	31
viral genome	31
membrane proteins	31
nir light	31
systemic symptoms	31
drug court	31
encapsulation efficiency	31
aag levels	31
healthy subjects	31
multidisciplinary team	31
angiotensin receptor	31
multidrug resistance	31
intestinal mucosa	31
posterior fossa	31
molecular structure	31
pulmonary toxicity	31
orally administered	31
light light	31
chronic inflammatory	31
chronic kidney	31
therapeutic effects	31
electrostatic interactions	31
mortality rates	31
data bank	31
antiretroviral drugs	31
protein structure	31
clinical impact	31
clinical course	31
induced pulmonary	31
care professionals	31
gastric acid	31
study period	31
early stage	31
fetal mri	31
intended use	30
year period	30
bacterial infection	30
medication review	30
preclinical studies	30
cell hyperplasia	30
multiple myeloma	30
publicly available	30
severe cutaneous	30
human genome	30
pharmacist intervention	30
frequently used	30
mediterranean fever	30
investigational drugs	30
patients using	30
enzyme inhibitors	30
may become	30
data mining	30
magnetic field	30
recently published	30
antibiotic therapy	30
recently emerged	30
retrospective cohort	30
qt interval	30
several drugs	30
fatty acids	30
delivery applications	30
also cause	30
metabolizing enzymes	30
contrast agent	30
cytokine release	30
may produce	30
young children	30
septic shock	30
familial mediterranean	30
network proximity	30
studies using	30
virus infections	30
lower respiratory	30
clinical study	30
health problems	30
drug exposure	30
growth hormone	30
bovine serum	30
growth factors	30
times higher	30
mononuclear cells	30
active metabolite	30
acid secretion	30
also provide	30
experimental data	30
docking study	29
diseased tissues	29
treatment strategies	29
aerosol therapy	29
fda approval	29
fi rst	29
factors associated	29
electron microscopic	29
future studies	29
viral protein	29
patients admitted	29
patients without	29
connective tissue	29
binding affinities	29
left ventricular	29
cell growth	29
sequence identity	29
recently reported	29
chemotherapeutic drugs	29
coronary artery	29
tissue engineering	29
ongoing clinical	29
real time	29
imaging modalities	29
total drug	29
oral cavity	29
urban health	29
imaging studies	29
enrichment analysis	29
two patients	29
colon cancer	29
lactic acidosis	29
effectively inhibit	29
inflammatory responses	29
blood samples	29
next generation	29
expression levels	29
quality control	29
therapeutic intervention	29
size distribution	29
better understand	29
pharmacokinetic parameters	29
liver transplant	29
western blot	29
serine protease	29
std nmr	29
dft theory	29
active targeting	29
liposomal doxorubicin	29
rna replication	29
cell populations	29
average age	28
biological activities	28
disease caused	28
idiopathic pulmonary	28
systems biology	28
genetic polymorphisms	28
currently used	28
injection drug	28
developing new	28
bacterial infections	28
multiple sclerosis	28
physical examination	28
biological systems	28
activity relationship	28
silica nanoparticles	28
clinical benefit	28
computational approach	28
nasal cavity	28
three main	28
using different	28
quantum dots	28
flexible endoscopes	28
potential use	28
neurodegenerative diseases	28
rational design	28
pulmonary oedema	28
predictive value	28
marine natural	28
essential role	28
like cells	28
carbon nanotube	28
years ago	28
transcription factors	28
dipole moment	28
antisense oligonucleotides	28
molecular modeling	28
urban areas	28
drug eruptions	28
training set	28
viral vectors	28
cell membranes	28
substance abuse	28
biological processes	28
label use	27
nonsteroidal anti	27
cns disorders	27
cell migration	27
previously reported	27
logistic regression	27
may induce	27
will focus	27
injection site	27
endothelial growth	27
drug companies	27
two major	27
therapeutic response	27
epr effect	27
interactome network	27
virus disease	27
test drug	27
target cell	27
gram staining	27
drug targeting	27
higher concentrations	27
adsorption energies	27
possible drug	27
rapid development	27
replication cycle	27
receptor activation	27
health system	27
early diagnosis	27
teaching hospital	27
viral dna	27
interaction prediction	27
various types	27
individual patients	27
san francisco	27
study shows	27
human diseases	27
first line	27
relatively high	27
educational content	27
ellagic acid	27
one drug	27
pl pro	27
limited number	27
health centre	27
molecular basis	27
studies showed	27
less likely	27
resistance mutations	27
pediatric radiologists	27
national institute	27
may contribute	27
effective drugs	27
near future	27
coronavirus infections	27
experimental study	27
clinical relevance	27
test set	27
among people	27
new approach	27
patients hospitalized	27
dna synthesis	27
current study	27
protein sequence	27
two weeks	27
passive targeting	27
exanthematous pustulosis	26
avian influenza	26
clinical outcome	26
body temperature	26
living cells	26
structural information	26
line treatment	26
research groups	26
endothelial cell	26
inner city	26
antimalarial drug	26
income countries	26
drug used	26
drug abuse	26
rat model	26
health service	26
action potential	26
dna polymerase	26
silico screening	26
drugs using	26
primary health	26
significantly associated	26
will help	26
normal cells	26
recent developments	26
several years	26
presentation will	26
negative individuals	26
cancer chemotherapy	26
skeletal muscle	26
rapid identification	26
administration period	26
vaccine delivery	26
acute phase	26
initial treatment	26
national health	26
scanning electron	26
proton pump	26
physical properties	26
opioid use	26
also occur	26
network analysis	26
nmr spectra	26
graphene oxide	26
antiviral research	26
water molecules	26
street youth	26
mammalian cells	26
many different	26
chronic bronchitis	26
state nmr	26
drug addition	26
dna repair	26
states food	26
data collected	26
see section	26
medication errors	26
brain mri	26
emerged novel	26
aerosol delivery	26
large scale	26
study conducted	26
major role	26
comparative study	26
use disorder	26
primary human	26
less toxic	26
lung deposition	26
ammonium group	26
chloroquine effectively	26
vast majority	26
high quality	26
aqueous solution	26
rna interference	26
therapeutic index	26
pharmacy service	26
human skin	25
disease prevention	25
inflammatory agents	25
multiple drugs	25
may act	25
economic impact	25
knockout mice	25
severe pneumonia	25
protein subcellular	25
interferon beta	25
clinical effects	25
transforming growth	25
dft study	25
already approved	25
social media	25
significantly different	25
alveolar epithelial	25
higher doses	25
targeted therapy	25
therapeutic agent	25
cells via	25
hospital stay	25
clinical findings	25
plga nanoparticles	25
less common	25
patient compliance	25
illicit drug	25
receptor antagonists	25
clinical response	25
free fraction	25
information regarding	25
reactive protein	25
promising results	25
drug information	25
different drugs	25
graph neural	25
health authorities	25
cytotoxic effects	25
new uses	25
cell signaling	25
one week	25
proton channel	25
among pwid	25
cells using	25
analysis showed	25
positively charged	25
clostridium difficile	25
image gently	25
another example	25
ic values	25
clinical manifestations	25
drug molecule	25
clinical implications	25
therapeutic strategy	25
coronavirus pneumonia	25
ml kg	25
drugs like	25
early detection	25
use authorization	25
leading cause	25
treatment period	25
base balance	25
feature set	25
chitosan nanoparticles	25
protective effect	25
target sites	25
lung cells	25
literature search	25
chest ct	25
residence time	25
drug usage	25
antiretroviral drug	25
available data	25
standard deviation	25
atypical pneumonia	25
children aged	25
fischer rats	25
case series	25
improve drug	25
different cell	25
dynamics simulations	25
time points	25
cervical cancer	25
responsive drug	25
us food	25
viral drugs	25
influenza viruses	25
repurposing approach	25
muscle cells	25
response rate	25
acute renal	25
japanese respiratory	24
acute generalized	24
poorly understood	24
repurposing drugs	24
based methods	24
age group	24
based nanoparticles	24
much higher	24
prescribed drugs	24
novel antiviral	24
oral dose	24
african trypanosomiasis	24
side chain	24
erythema multiforme	24
community health	24
novel therapeutic	24
significant decrease	24
fungal infections	24
significant association	24
squamous metaplasia	24
hydrogen peroxide	24
escape mutants	24
health problem	24
broad range	24
provide information	24
case study	24
daily dose	24
squamous epithelium	24
recovery time	24
control study	24
web server	24
systemic involvement	24
executive summary	24
therapeutic option	24
fever virus	24
vitro evaluation	24
ii trial	24
venom peptides	24
pictorial review	24
plasmid dna	24
supplementary table	24
old drugs	24
liver cancer	24
stimulus responsive	24
may affect	24
available drugs	24
normal tissues	24
building blocks	24
ace receptor	24
diseases like	24
functional genomics	24
older adults	24
based design	24
respiratory society	24
signal intensity	24
one year	24
adaptive immune	24
pharmacophore models	24
social services	24
study using	24
care services	24
molecule drugs	24
hospital pharmacists	24
hydroxychloroquine sulfate	24
infections caused	24
mechanically ventilated	24
marketing authorization	24
parietal cells	24
docking scores	24
gold standard	24
channel blockers	24
clinical experience	24
structural biology	24
version posted	24
bioactive delivery	24
bioactive compounds	24
inhalation therapy	24
generalized exanthematous	24
resistant strains	24
included patients	24
manual cleaning	24
extracellular matrix	24
secondary metabolites	24
using high	24
therapeutic use	24
novel approach	24
various diseases	24
subcellular localization	24
new chemical	24
se bond	24
two cases	24
resistant mutants	24
healthy individuals	24
renal disease	24
imaging techniques	24
overdose deaths	24
vaccine development	24
drosophila melanogaster	24
low cost	24
antiviral properties	23
use disorders	23
potential target	23
cell count	23
confirmed cases	23
burst release	23
myeloid leukemia	23
docking score	23
also demonstrated	23
serious adverse	23
positive bacteria	23
will allow	23
preliminary results	23
vivo evaluation	23
long half	23
liquid chromatography	23
clinical evidence	23
novo drug	23
disease severity	23
spike glycoprotein	23
analysed using	23
steady state	23
infected pneumonia	23
past decade	23
deficient mice	23
precision medicine	23
drug sensor	23
people living	23
enzymatic activity	23
proton transport	23
adverse reaction	23
mitotic activity	23
ct scans	23
dry cough	23
human liver	23
renal insufficiency	23
conducted using	23
targeting ligands	23
i clinical	23
health outcomes	23
success rate	23
inflammatory drug	23
proteins involved	23
cutaneous adrs	23
predicting drug	23
learning methods	23
may include	23
bowel obstruction	23
north america	23
within days	23
cell carcinoma	23
bronchiolitis obliterans	23
following administration	23
pulmonary edema	23
laboratory tests	23
molecular biology	23
secondary structure	23
activated protein	23
inhaled protein	23
connectivity map	23
new indication	23
sore throat	23
drug levels	23
social justice	23
graph completion	23
nanostructured lipid	23
intervention group	23
antiviral compounds	23
different mechanisms	23
cell division	23
tumor tissues	23
ligand interactions	23
induced liver	23
analysis using	23
tertiary care	23
clinical improvement	23
based approaches	23
poisoned patients	23
lymphatic vessels	23
sensing ion	23
excess charge	23
health needs	23
orphan drug	23
drug policy	23
comprehensive review	23
ph values	23
mediated endocytosis	23
membrane fusion	23
inhibit sars	23
unique properties	23
subcellular location	22
large amounts	22
three drugs	22
tissue distribution	22
wistar rats	22
endoscope reprocessing	22
assessed using	22
big data	22
hcv treatment	22
colonic mucosa	22
transcriptomic data	22
first choices	22
social distancing	22
cells treated	22
first choice	22
bile acid	22
mri findings	22
injecting drug	22
bronchoalveolar lavage	22
disease states	22
molecular descriptors	22
genome sequence	22
drug transporters	22
medical applications	22
based discovery	22
metered dose	22
virus association	22
pump inhibitors	22
acting antiviral	22
animal testing	22
hospital treatment	22
aged years	22
binding ligands	22
induced hepatotoxicity	22
lymphatic targeting	22
drug research	22
chikungunya virus	22
air pollution	22
rapid addition	22
tyrosine kinases	22
highly conserved	22
also called	22
drugs will	22
focus group	22
resistant tuberculosis	22
butylated hydroxyanisole	22
take advantage	22
murine model	22
genetic engineering	22
international license	22
asbestos fibres	22
hek cells	22
france please	22
prescription drugs	22
cardiac arrest	22
inhibiting viral	22
vitro activity	22
great potential	22
within min	22
united kingdom	22
second choices	22
conformational changes	22
medication use	22
bowel irrigation	22
will continue	22
associated lymphoid	22
molecular imaging	22
loaded plga	22
iii clinical	22
treatment response	22
service providers	22
patients suffering	22
social support	22
much lower	22
social capital	22
patients showed	22
gla loaded	22
host interactome	22
energy calculations	22
related mortality	22
carbonic anhydrase	22
photothermal therapy	22
lipid bilayer	22
carcinoma cells	22
veterinary medicine	22
one hand	22
chronic inflammation	22
drug toxicity	22
study will	22
developing world	21
basic research	21
may show	21
based materials	21
mg every	21
may vary	21
see chapter	21
binding mode	21
tumor volume	21
body surface	21
cutaneous drug	21
lead compounds	21
polymer hybrid	21
medicinal products	21
asbestos bodies	21
cell imaging	21
release rate	21
low toxicity	21
nmr experiments	21
six months	21
chest wall	21
protein nanoparticles	21
syndromic surveillance	21
general practitioners	21
studies indicate	21
genetic factors	21
protein interactome	21
enteric bacteria	21
medical care	21
human african	21
experimental studies	21
paediatric patients	21
guar gum	21
useful tool	21
medicines agency	21
support vector	21
descriptive study	21
quasispecies dynamics	21
water solubility	21
controlled delivery	21
differentially expressed	21
determine whether	21
surface charge	21
vitro model	21
single drug	21
new antibiotics	21
drug eruption	21
ventilated patients	21
delivery vehicles	21
vitro study	21
blood circulation	21
free radicals	21
vitro assays	21
liver transplantation	21
results demonstrate	21
quantitative structure	21
cancer treatments	21
brain injury	21
interaction network	21
one example	21
therapeutic approaches	21
cholinesterase inhibitors	21
ct imaging	21
class i	21
new antiviral	21
adsorption properties	21
readily available	21
already known	21
often associated	21
cardiac output	21
may develop	21
liver toxicity	21
based pharmacophore	21
potential candidates	21
known drug	21
mucous membranes	21
give rise	21
patients included	21
cardiac hypertrophy	21
basis set	21
species differences	21
cell activation	21
using dft	21
polymeric micelles	21
highly expressed	21
tumor vasculature	21
qsar models	21
compounding errors	21
infection control	21
gene silencing	21
tissue damage	21
maximum adsorption	21
oral doses	21
least two	21
four patients	21
including sars	21
acute bronchitis	21
coronavirus sars	21
signifi cantly	21
paneth cells	21
environmental factors	21
chemical compounds	21
electronic properties	21
antiviral treatment	20
empiric therapy	20
causative agent	20
health emergency	20
also seen	20
treatment duration	20
sectional study	20
st century	20
low doses	20
drug selection	20
cutaneous leishmaniasis	20
viral hepatitis	20
potential role	20
competing interests	20
neuraminidase inhibitors	20
mucociliary clearance	20
french addictovigilance	20
safety profiles	20
guinea pigs	20
cmax ec	20
developed countries	20
new treatments	20
two years	20
kg per	20
narrow therapeutic	20
therapeutic approach	20
cell lymphoma	20
autodock vina	20
old drug	20
photodynamic therapy	20
induced apoptosis	20
gastrointestinal endoscopes	20
pharmacokinetic data	20
mental status	20
cancer therapies	20
homology model	20
drug compounds	20
medication reviews	20
genetic testing	20
classification system	20
glandular mucosa	20
dosage adjustment	20
creatinine clearance	20
gene set	20
highly specific	20
acid sequence	20
educational exhibit	20
silk fibroin	20
cardiac function	20
anticholinergic drugs	20
urban poor	20
recent progress	20
set enrichment	20
specific protein	20
carbon atoms	20
pharmaceutical services	20
side chains	20
strand breaks	20
glomerular filtration	20
systemic toxicity	20
cardiac glycosides	20
small size	20
safety concerns	20
fi eld	20
solvation energy	20
first case	20
without affecting	20
cell wall	20
acid load	20
elimination half	20
development process	20
influenza infections	20
allergic reactions	20
also important	20
global pandemic	20
adipose tissue	20
least three	20
studied using	20
flow rate	20
taz pipc	20
repurposed drug	20
metabolic pathways	20
resistance mechanisms	20
new generation	20
various forms	20
descriptor set	20
future drug	20
nuclear receptor	20
hospital admission	20
dose inhalers	20
reference drugs	20
stranded rna	20
preliminary report	20
antineoplastic agents	20
effects like	20
like peptide	20
sensitive systems	20
study demonstrates	20
mental illness	20
potential benefits	20
pharmacological treatment	20
hemolytic anemia	20
silico methods	20
identified using	20
otitis media	20
compounding pharmacies	20
lessons learned	20
powder inhalers	20
psychotropic drugs	20
target genes	20
treatment option	20
immunosuppressive drugs	20
calculated using	20
protein complex	20
density functional	20
european medicines	20
hypersensitivity syndrome	20
site residues	20
model drug	20
parenteral nutrition	20
working group	20
carrier systems	20
fight covid	20
mechanisms underlying	20
ulcerative colitis	20
protein drug	20
free binding	20
controlled clinical	20
mean square	20
us fda	20
sars infection	20
potential application	20
approach using	20
every hours	20
silico studies	20
toxicity profile	19
sars cov	19
chemical stability	19
hiv treatment	19
predicting protein	19
combination therapies	19
although many	19
offending drug	19
stratum corneum	19
nucleocapsid protein	19
activity relationships	19
cardiac remodeling	19
renal tubular	19
presenting cells	19
treatment guidelines	19
data available	19
cancer risk	19
promising candidate	19
pass metabolism	19
high drug	19
compounding pharmacy	19
natural killer	19
serum concentration	19
lung function	19
must also	19
several days	19
oral activated	19
medical treatment	19
large intestine	19
develop new	19
bacterial resistance	19
potentially inappropriate	19
severe adverse	19
plga nps	19
regression analysis	19
medication discrepancies	19
associated protein	19
one case	19
past two	19
cardiac fibroblasts	19
chronic pain	19
kidney injury	19
treatment failure	19
within hours	19
clinical signs	19
specific targeting	19
treated group	19
phase clinical	19
renal excretion	19
less frequently	19
protein bound	19
mycoplasma pneumoniae	19
th century	19
agonist therapy	19
sleeping sickness	19
may serve	19
metabolic activity	19
disease management	19
vitro data	19
well established	19
gastrointestinal endoscopy	19
mass index	19
tissue sections	19
patients affected	19
chronic disease	19
maintenance treatment	19
lung damage	19
lung parenchyma	19
may involve	19
based systems	19
glycogen synthase	19
protein targets	19
docking studies	19
antibody fragments	19
pulmonary arteries	19
showed significant	19
also performed	19
analysis revealed	19
urine samples	19
takes place	19
diagnostic imaging	19
pivotal role	19
take place	19
release kinetics	19
novel drugs	19
pediatric patient	19
principal component	19
covalent inhibitors	19
rhesus monkeys	19
nasogastric tube	19
test results	19
histological features	19
new class	19
delivery devices	19
drug therapies	19
intellectual property	19
kg twice	19
ii study	19
rational drug	19
patient population	19
therapeutic proteins	19
histological examination	19
biofilm formation	19
investigate whether	19
studies revealed	19
depressive symptoms	19
clinical significance	19
systemic exposure	19
physical activity	19
following oral	19
potential candidate	19
active ingredient	19
cell population	19
practice guidelines	19
known drugs	19
patients presented	19
histone deacetylase	19
acid sequences	19
iontophoretic drug	19
protein therapeutics	19
qualitative study	19
randomized trial	19
protective effects	19
interaction networks	19
therapeutic applications	19
arachidonic acid	19
gastric emptying	19
potent inhibitors	19
subcutaneous injection	19
month period	19
pharmacy practice	19
will review	19
day second	19
drugbank database	19
theragnostic tests	19
five patients	18
snake venom	18
healthy adults	18
mitochondrial dysfunction	18
aided drug	18
retrospective analysis	18
transgenic mouse	18
calcium phosphate	18
inflammatory disease	18
release syndrome	18
nitride nanotubes	18
concomitant use	18
physiological conditions	18
proinflammatory cytokines	18
psychiatric disorders	18
cyp enzymes	18
body mass	18
tuberculosis treatment	18
gastric glands	18
kinase activity	18
statistical significance	18
enzymes involved	18
ribose methyltransferase	18
protein structural	18
high sensitivity	18
initial phase	18
inhibitory concentration	18
deep matrix	18
dna viruses	18
powder inhaler	18
previous work	18
data obtained	18
quercetin slms	18
alveolar epithelium	18
clinical setting	18
inflammatory mediators	18
safety issues	18
mg per	18
liver dysfunction	18
antiviral efficacy	18
mucous cells	18
nasal mucosa	18
goblet cell	18
term treatment	18
human breast	18
high molecular	18
covalent bond	18
coronavirus spike	18
circulation time	18
age years	18
pharmacological properties	18
morphological changes	18
associated proteins	18
therapeutic doses	18
serum concentrations	18
exhibit will	18
absorptive cells	18
drugs approved	18
dendritic cell	18
dawley rats	18
pulmonary function	18
drug dosage	18
higher sensitivity	18
cell nmr	18
hepatic metabolism	18
whole blood	18
eye drops	18
beneficial effects	18
liver enzymes	18
transcriptase inhibitors	18
ionizing radiation	18
hepatic failure	18
specific drugs	18
may reduce	18
viral disease	18
hela cells	18
several factors	18
highly effective	18
used drugs	18
apparent efficacy	18
also evaluated	18
plasma half	18
significant effect	18
bioactive molecules	18
culture medium	18
lipid carriers	18
genetically engineered	18
many studies	18
imaging modality	18
local drug	18
acetic acid	18
recombinant human	18
among different	18
mean number	18
binding energies	18
starting point	18
thermal stability	18
chemical modifications	18
clinically proven	18
mg daily	18
generated using	18
sexually transmitted	18
small amounts	18
induced hypersensitivity	18
one month	18
related deaths	18
continuous infusion	18
nuclear factor	18
mice treated	18
small number	18
fold greater	18
pain management	18
may offer	18
abdominal pain	18
drug solution	18
evidence suggests	18
diabetic rats	18
human studies	18
varying degrees	18
low income	18
visceral leishmaniasis	18
label non	18
may explain	18
acute myeloid	18
transdermal drug	18
total cholesterol	18
first reported	18
three patients	18
outpatient treatment	18
significant impact	18
molecular level	18
drug sensitivity	18
intravenous immunoglobulin	18
filtration rate	18
west nile	18
expression data	18
zeta potential	18
measured using	18
molecular modelling	18
bipolar disorder	18
using nmr	18
binding proteins	18
medical record	18
diagnostic tests	18
specific disease	18
study demonstrated	18
inflammatory process	18
focus groups	18
one third	18
membrane transporters	18
cell survival	18
protein folding	18
polymers based	18
may need	18
healthcare system	18
potential anti	18
covalent bonds	18
dietary phytochemicals	18
viral particles	18
also reduced	18
certain drugs	18
massive fibrosis	18
clinical pharmacokinetics	17
identifi cation	17
mol respectively	17
treatment regimen	17
rats fed	17
pulmonary artery	17
similar changes	17
proposed method	17
stimulating factor	17
cells showed	17
effl ux	17
patient education	17
vascular anomalies	17
antimicrobial peptide	17
pharmaceutical analysis	17
confidence interval	17
study design	17
acute inflammatory	17
first two	17
degradation rate	17
highly active	17
galactosidase enzyme	17
aerosolized drug	17
antiviral action	17
positive results	17
identify drug	17
pharmacy students	17
particular drug	17
shown apparent	17
lipid metabolism	17
regulatory agencies	17
bond energy	17
emerging viral	17
studies performed	17
authors also	17
potential clinical	17
european union	17
interfering rna	17
liver damage	17
treatment outcomes	17
total amount	17
nucleotide sequence	17
extensively studied	17
protein complexes	17
global hardness	17
acinar cells	17
another type	17
liver cirrhosis	17
ii clinical	17
positive control	17
risk management	17
ct findings	17
rat lung	17
ten years	17
residence times	17
nitrobenzyl group	17
common cause	17
clinical application	17
day course	17
animal species	17
endoscope channels	17
urban settings	17
also show	17
drug deposition	17
retrospective observational	17
different levels	17
old male	17
glycyrrhizic acid	17
receptor mediated	17
pulmonary arterial	17
alcian blue	17
tissue culture	17
differ significantly	17
neutralizing antibodies	17
immunodeficiency syndrome	17
pulse sequence	17
compounds may	17
study aimed	17
coated tablets	17
odds ratio	17
another drug	17
previous study	17
linear regression	17
acquired immunodeficiency	17
akt mtor	17
herpes virus	17
receptor agonist	17
identifi ed	17
progressive massive	17
another important	17
human blood	17
become available	17
heat shock	17
acid substitutions	17
identify new	17
chemical properties	17
might also	17
outpatient clinic	17
also shows	17
tricyclic antidepressant	17
collected data	17
high prevalence	17
improved drug	17
high mortality	17
population size	17
outbreak associated	17
class ii	17
cell transformation	17
ii receptor	17
drug leads	17
new therapies	17
pol ii	17
patients diagnosed	17
fitness cost	17
kidney function	17
model using	17
pharmacophore modeling	17
cardiovascular system	17
control drugs	17
release profile	17
transmission electron	17
herbal products	17
informed consent	17
general practitioner	17
promising drug	17
clara cells	17
blood cell	17
renal dysfunction	17
schematic representation	17
vitro methods	17
first day	17
also associated	17
taking advantage	17
kg body	17
randomly selected	17
human respiratory	17
predicted drugs	17
studies will	17
service delivery	17
evaluated using	17
high binding	17
computational studies	17
care facilities	17
data sources	17
cationic liposomes	17
particularly important	17
nude mice	17
sensory neurons	17
respiratory depression	17
five years	17
reduced toxicity	17
finding new	17
cleavage site	17
potential risk	17
virus rna	17
mental disorders	17
results indicated	17
pediatric radiologist	17
direct effect	17
mm gbsa	17
advanced breast	17
human ace	17
line therapy	17
positive impact	17
dose group	17
blood plasma	17
severe disease	17
specific antibody	17
synergistic effects	17
clin pharm	17
polymeric nanocapsules	17
animal experiments	17
laboratory data	17
different studies	17
experimental drugs	17
inflammatory activity	17
nucleotide polymorphisms	17
coumarin derivatives	17
manuscript www	17
future perspectives	17
cancer types	16
biological properties	16
large amount	16
time consuming	16
thymidine kinase	16
also play	16
common adverse	16
basic drugs	16
triblock copolymers	16
coronavirus replication	16
cancer therapeutics	16
binding modes	16
skin lesions	16
type drug	16
grapefruit juice	16
single nucleotide	16
homeless people	16
enterochromaffin cells	16
resistance genes	16
cancer agents	16
hyaluronic acid	16
acoh redox	16
studies show	16
particularly useful	16
biological barriers	16
also considered	16
zn acoh	16
sialic acid	16
ductus arteriosus	16
thoracic society	16
poor prognosis	16
nucleoside reverse	16
adjacency matrix	16
originally developed	16
commonly found	16
inflammatory conditions	16
among plhcv	16
inhaled drug	16
similar results	16
congestive heart	16
best practices	16
vibrating mesh	16
arterial hypertension	16
low level	16
dithiothreitol redox	16
cellular targets	16
virtual hits	16
viral spike	16
list prices	16
light nir	16
serum sickness	16
medical imaging	16
pneumonia outbreak	16
lead monitoring	16
energy metabolism	16
ph responsive	16
portal vein	16
capping group	16
medicinal plant	16
antiinflammatory drugs	16
approved medicines	16
systemic absorption	16
mg bd	16
transferrin receptor	16
multicenter study	16
interacting proteins	16
gastric glandular	16
retinoic acid	16
graph convolutional	16
safe use	16
release drug	16
catalytic site	16
protease enzyme	16
signifi cant	16
knowledge base	16
light microscopy	16
air activity	16
therapeutic protein	16
structural changes	16
image noise	16
adults hospitalized	16
beagle dogs	16
envelope protein	16
squamous cell	16
hiv disease	16
alzheimer disease	16
cycle arrest	16
short period	16
thiols redox	16
positive patients	16
receptor tyrosine	16
biological evaluation	16
old man	16
mg micromotors	16
phosphatase enzyme	16
new quinolones	16
dust pneumoconiosis	16
glucuronidase enzyme	16
intestinal epithelial	16
pegylated liposomal	16
resistant staphylococcus	16
diseases society	16
cytokine production	16
previously published	16
cytotoxic drugs	16
scoring functions	16
preclinical models	16
indirect sharing	16
will include	16
null mice	16
ang ii	16
diagnostic accuracy	16
human papillomavirus	16
electrostatic interaction	16
klebsiella pneumoniae	16
median time	16
target effects	16
determined using	16
patients reported	16
lung delivery	16
dual stimuli	16
life threatening	16
single oral	16
low micromolar	16
related coronavirus	16
ec value	16
rapid drug	16
new approaches	16
adverse side	16
poorly water	16
adsorption process	16
low concentrations	16
marketed drugs	16
alveolar walls	16
drugs including	16
age range	16
common among	16
fat diet	16
novo design	16
host response	16
plasmin enzyme	16
related diseases	16
acute kidney	16
digestive system	16
studies demonstrated	16
multiple drug	16
ester carbamate	16
severe symptoms	16
like receptor	16
serum creatinine	16
tumor targeting	16
drug pairs	16
dna double	16
different diseases	16
agents may	16
worth noting	16
cl protease	16
scale production	16
three types	16
care service	16
root mean	16
bsa enzyme	16
coumaric acid	16
silico analysis	16
ejection fraction	16
feature selection	16
observation period	16