bigram

This is a table of type bigram and their frequencies. Use it to search & browse the list to learn more about your study carrel.

bigram	frequency
stem cell	1831
cell transplantation	1234
bone marrow	931
mg kg	747
peripheral blood	740
median age	623
hematopoietic stem	608
extracellular vesicles	584
summary conclusion	561
patients received	547
stem cells	528
overall survival	524
conditioning regimen	511
cd cells	472
chronic gvhd	464
acute gvhd	463
host disease	452
one patient	424
median time	378
median follow	375
nervous system	374
brain injury	357
cerebrospinal fluid	345
spinal cord	336
flow cytometry	329
allogeneic hematopoietic	309
gvhd prophylaxis	305
multiple sclerosis	303
high risk	298
free survival	296
risk factors	293
cd cd	291
two patients	283
central nervous	265
nk cells	256
complete remission	250
allogeneic stem	250
ng ml	250
significantly higher	244
immune response	243
cord blood	241
care unit	241
blood stem	240
stimulating factor	240
cell lines	224
unrelated donor	221
subarachnoid hemorrhage	220
multiple myeloma	219
pg ml	216
neurocritical care	216
allogeneic hsct	212
statistically significant	210
intensive care	210
graft versus	209
patients undergoing	208
patients receiving	207
mean age	204
cmv reactivation	195
control group	194
two groups	193
graft failure	193
autologous stem	192
versus host	191
traumatic brain	189
ischemic stroke	186
status epilepticus	186
cumulative incidence	183
mg dl	182
myeloablative conditioning	181
myeloid cells	181
significant difference	181
cd cell	180
endothelial cells	178
high dose	176
retrospective study	176
multivariate analysis	175
patients treated	173
blood pressure	173
kg day	171
septic shock	170
white matter	170
clinical trials	170
inflammatory response	169
cell count	168
mechanical ventilation	167
myeloid leukemia	167
acute myeloid	165
acute respiratory	164
patients admitted	163
side effects	161
three patients	160
adult patients	159
related mortality	158
ms patients	158
cell transplant	157
grade ii	156
electron microscopy	156
university hospital	155
clinical signs	155
donor chimerism	154
reduced intensity	153
mononuclear cells	152
growth factor	152
data suggest	150
conditioning regimens	150
patients died	148
marrow transplantation	147
five patients	146
within hours	146
derived evs	146
bacterial meningitis	145
four patients	145
case report	145
poor outcome	144
may also	144
patients without	144
intensity conditioning	143
consecutive patients	142
dendritic cells	142
matched unrelated	142
nanoparticle tracking	140
respiratory failure	139
cardiac arrest	138
adverse events	138
grade iii	137
tracking analysis	136
clinical trial	135
patients developed	134
logistic regression	134
virus infection	133
significant differences	133
years old	132
intracranial pressure	132
critically ill	130
immune reconstitution	129
cancer cells	128
western blot	128
acute graft	127
necrosis factor	127
long term	127
relapse mortality	126
organ failure	126
disease progression	125
days post	125
cell source	124
breast cancer	124
unrelated donors	124
increased risk	123
acute leukemia	123
dose chemotherapy	122
gene expression	122
severe acute	121
blood samples	120
cell lymphoma	120
hematopoietic cell	119
significantly associated	119
pediatric patients	118
cell line	118
ex vivo	118
risk factor	117
blood flow	116
growth factors	116
cell types	115
median number	115
lung injury	114
immune system	113
magnetic resonance	113
months post	112
year os	112
year old	112
neopterin levels	111
platelet engraftment	110
disease status	110
significantly reduced	110
intracerebral hemorrhage	110
well tolerated	109
univariate analysis	109
viral infections	109
neutrophil engraftment	108
single center	108
epithelial cells	107
present study	106
tumor necrosis	106
performed using	106
healthy donors	106
immune cells	105
patients underwent	105
retrospective analysis	104
cell dose	104
progenitor cells	104
among patients	104
acute lymphoblastic	104
cerebral edema	104
cancer patients	103
mortality rate	102
infectious complications	101
resonance imaging	101
hematological malignancies	100
important role	99
significantly lower	99
medical center	99
brain barrier	98
lymphoblastic leukemia	98
patient developed	98
viral infection	98
body weight	97
results suggest	96
mesenchymal stem	95
respiratory distress	95
cd ra	95
monoclonal antibody	95
whole blood	94
matched sibling	94
significantly increased	94
patient died	94
critical care	93
cmv infection	92
brain tissue	92
cell proliferation	92
brain death	91
retrospectively analyzed	91
protein concentration	91
aplastic anemia	91
six patients	91
mass spectrometry	90
poor prognosis	90
haematopoietic stem	90
case series	90
matched related	89
sibling donor	89
immune responses	88
seven patients	88
acute phase	88
mixed chimerism	88
cell surface	87
granulocyte colony	87
nitric oxide	87
trem variants	87
infectious peritonitis	87
first days	87
cell depletion	87
clinical features	87
respiratory syndrome	87
ill patients	87
viral load	87
colony stimulating	86
transmission electron	86
macrophage colony	86
high levels	86
patients transplanted	86
hsct recipients	86
feline infectious	86
prostate cancer	85
blood cell	85
total body	85
acute ischemic	85
median duration	85
age years	85
hodgkin lymphoma	85
healthy controls	84
chronic graft	84
year overall	84
alveolar macrophages	84
trem expression	84
clinical course	83
haploidentical donor	83
usa introduction	83
cohort study	83
united states	83
within days	83
cells kg	83
blood cells	83
cancer cell	83
survival rate	82
doc id	82
informed consent	82
pts received	82
cord uid	82
nk cell	82
mycophenolate mofetil	82
cell death	82
cytokine production	82
ct scan	82
renal failure	81
extracellular vesicle	81
relapse rate	81
csf samples	81
animal models	81
recipient cells	80
time points	80
partial response	80
progressive disease	80
lumbar puncture	80
least one	79
umbilical cord	79
plasma levels	79
grade i	79
cell culture	79
serum levels	79
icu admission	79
inflammatory cytokines	79
exclusion chromatography	79
eight patients	79
chain reaction	78
septic patients	78
low dose	77
prospective study	77
regression analysis	76
one year	76
complete response	76
polymerase chain	76
analysis showed	76
response rate	75
myelodysplastic syndrome	75
aml patients	75
old male	75
may lead	75
reactive protein	75
findings suggest	75
cell therapy	75
cell counts	74
patients showed	74
patient received	74
adhesion molecules	74
lymph nodes	74
risk patients	74
significantly different	73
statistical analysis	73
derived exosomes	73
mouse model	73
mm hg	73
intracranial hemorrhage	73
coronavirus disease	73
copies ml	72
post transplant	72
wound healing	72
nine patients	72
distress syndrome	72
monoclonal antibodies	72
white blood	71
clinical outcome	71
blood mononuclear	71
medical records	71
cryptococcal meningitis	71
alveolar proteinosis	71
mental status	71
western blotting	71
basic protein	71
multiple organ	70
partial remission	70
chart review	70
patients suffering	70
functional outcome	70
total protein	70
statistical significance	70
body irradiation	70
infected patients	70
line therapy	69
hospital mortality	69
mm patients	69
may occur	69
csf analysis	69
full donor	69
derived extracellular	69
mast cells	69
based conditioning	69
sah patients	68
autoimmune diseases	68
recent studies	68
blood cultures	68
median cd	68
significant increase	68
residual disease	68
two cases	68
related donor	67
respiratory tract	67
identical sibling	67
computed tomography	67
previous studies	67
transplant related	67
platelet count	67
plasma samples	67
adverse effects	67
patients presented	67
may contribute	66
head ct	66
one case	66
hematologic malignancies	66
glasgow coma	66
healthy volunteers	66
modified rankin	65
nasal polyps	65
type i	65
previously described	65
stromal cells	65
aneurysmal subarachnoid	65
also found	65
clinical characteristics	64
study period	64
iv acute	64
increased levels	64
higher risk	64
size exclusion	64
old female	63
disease relapse	63
clinical data	63
clinical outcomes	63
treatment option	63
declare background	63
good outcome	63
determine whether	63
donor lymphocyte	63
inclusion criteria	63
red blood	62
brain mri	62
cerebral blood	62
phase ii	62
allogeneic transplantation	62
patient population	62
significant reduction	62
day post	62
cell activation	62
neurological complications	62
specific antibodies	62
intracranial hypertension	62
died due	62
commonly used	62
brain edema	62
bacterial infections	61
allogeneic sct	61
influenza virus	61
patients may	61
results indicate	61
retrospectively reviewed	61
mri brain	61
pilot study	61
cytokine release	61
organ dysfunction	61
analysis revealed	61
gvhd grade	61
case reports	61
natural killer	61
cell depleted	61
disease free	61
relapsed refractory	61
prospective studies	60
transplant cyclophosphamide	60
may result	60
higher incidence	60
active disease	60
may help	60
patients aged	60
old woman	60
host defense	60
donor type	60
adhesion molecule	59
immunosuppressive therapy	59
ev isolation	59
transplant recipients	59
disease severity	59
clinical practice	59
prophylaxis consisted	59
head injury	59
cytokine storm	59
mg ml	59
tumor cells	58
phase i	58
days later	58
treated patients	58
myeloma patients	58
graft rejection	58
cerebral perfusion	58
neurological symptoms	58
stroke patients	58
density gradient	58
future studies	58
cerebral ischemia	58
endothelial cell	57
cells ml	57
patients achieved	57
autologous hsct	57
viral meningitis	57
tumour cells	57
rheumatoid arthritis	57
previously reported	57
first hours	57
last follow	57
surface markers	57
salvage therapy	56
neurological manifestations	56
ten patients	56
included patients	56
old man	56
myeloid cell	56
first time	56
pulmonary alveolar	56
observational study	56
neurological examination	56
lung cancer	56
cell viability	56
early diagnosis	56
major cause	55
differential diagnosis	55
patients presenting	55
smooth muscle	55
may play	55
significantly decreased	55
lymphoma patients	55
weight loss	55
csf protein	55
cd count	55
differentially expressed	55
transplanted patients	55
immune cell	55
autologous hematopoietic	55
induction therapy	54
infectious diseases	54
amino acid	54
cerebral artery	54
emergency department	54
per cent	54
independently associated	54
primary outcome	54
coma scale	54
severe sepsis	54
widely used	54
csf levels	54
tbi patients	54
first line	54
elevated levels	54
fungal infections	53
marrow transplant	53
nucleated cells	53
patients experienced	53
occlusive disease	53
target cells	53
regression model	53
hemorrhagic cystitis	53
supportive care	53
first year	53
measured using	53
underlying disease	53
renal function	53
clinical presentation	53
retrospective review	52
retrospective chart	52
sample size	52
platelet recovery	52
acute lung	52
inflammatory responses	52
protein levels	52
per day	52
factors associated	52
tissue damage	52
mg day	52
small rna	52
year period	52
generation sequencing	52
common cause	52
elderly patients	51
clinical symptoms	51
critical illness	51
size distribution	51
may provide	51
conditioned media	51
deficient mice	51
underwent allogeneic	51
one cat	51
herpes simplex	51
studies suggest	51
ebv reactivation	51
skeletal muscle	51
class ii	50
diagnostic criteria	50
physical examination	50
systematic review	50
median days	50
escherichia coli	50
cell subsets	50
significant improvement	50
type ii	50
higher levels	50
patients engrafted	50
study group	50
developed acute	49
trend towards	49
neutrophil recovery	49
fungal infection	49
predictive value	49
minimal residual	49
tyrosine kinase	49
high mortality	49
risk group	49
data indicate	49
recombinant human	49
apache ii	49
hospital stay	49
antifungal therapy	48
receptor expressed	48
triggering receptor	48
sos vod	48
neurological signs	48
elevated protein	48
malignant disease	48
cd kg	48
acute brain	48
clinical studies	48
weighted images	48
neurological deficits	48
controlled trial	48
class i	48
hypertonic saline	48
haploidentical transplantation	48
relapse incidence	48
undergoing allogeneic	48
small extracellular	47
invasive fungal	47
results demonstrate	47
poorly understood	47
hla matched	47
haploidentical donors	47
immunodeficiency virus	47
differential ultracentrifugation	47
therapeutic hypothermia	46
median day	46
oxidative stress	46
haploidentical hsct	46
underwent allo	46
time point	46
positive cells	46
identified patients	46
poor outcomes	46
kg bw	46
underwent hsct	46
severe tbi	46
solid tumors	46
novel coronavirus	46
median os	46
key role	46
significantly better	46
curative treatment	46
related complications	45
barr virus	45
day mortality	45
retrospective cohort	45
innate immune	45
remaining patients	45
extracellular matrix	45
inflammatory diseases	45
nucleic acids	45
proinflammatory cytokines	45
also observed	45
rankin scale	45
results show	45
abdominal pain	45
regimen consisted	45
neutropenia recovery	45
iv agvhd	45
three groups	45
ct scans	45
prognostic factors	45
conditioned medium	45
confidence interval	45
ev markers	44
elevated icp	44
disease control	44
paediatric patients	44
term follow	44
effective treatment	44
cell population	44
isolated evs	44
nucleated cell	44
kg cd	44
antithymocyte globulin	44
cell function	44
serum samples	44
injured patients	44
mri showed	44
term outcome	44
evs derived	44
urinary tract	44
symptom onset	44
consecutive days	44
mouse models	44
animal model	44
monocytes macrophages	44
ad patients	44
cryptococcus neoformans	44
melphalan mg	43
peripheral stem	43
cell type	43
liquid biopsy	43
refractory disease	43
cognitive impairment	43
progression free	43
antibiotic therapy	43
autologous transplantation	43
respiratory symptoms	43
intercellular communication	43
graft source	43
myocardial infarction	43
total number	43
undergoing hsct	43
sibling donors	43
marrow failure	43
months later	43
allogeneic hct	43
patients diagnosed	43
cell mobilization	43
atg group	43
developed grade	43
ev cargo	43
post hsct	43
bacterial infection	43
normal range	43
gastrointestinal tract	43
infected cats	43
transcription factor	42
first case	42
external ventricular	42
effector cells	42
significant correlation	42
amino acids	42
mrna expression	42
recent study	42
extensive chronic	42
altered mental	42
line treatment	42
one study	42
two cats	42
severe chronic	42
cd expression	42
cns infection	42
twice daily	42
fl ammatory	42
release syndrome	42
hours post	42
body temperature	42
fludarabine mg	41
center experience	41
autologous peripheral	41
thymocyte globulin	41
sickle cell	41
wild type	41
culture media	41
patients compared	41
ev release	41
assessed using	41
blood volume	41
mass effect	41
refractory status	41
medical history	41
patient care	41
syndrome coronavirus	41
eosinophilic esophagitis	41
mcg kg	41
central venous	41
therapeutic approach	41
maintenance therapy	41
mismatched unrelated	41
preliminary results	40
inflammatory mediators	40
bronchoalveolar lavage	40
dendritic cell	40
natural history	40
significantly improved	40
studies showed	40
heart rate	40
may cause	40
lyme disease	40
systemic inflammatory	40
surgical intervention	40
six months	40
received myeloablative	40
mortality rates	40
one patients	40
intraventricular hemorrhage	40
protein content	40
old girl	40
hospital discharge	40
stable disease	40
extracorporeal photopheresis	40
cell adhesion	40
even though	40
patients will	40
preliminary data	39
leading cause	39
results showed	39
immune activation	39
respiratory syncytial	39
data show	39
two different	39
neurologic complications	39
patient characteristics	39
myelin basic	39
one hundred	39
immunocompromised patients	39
allogeneic haematopoietic	39
basal ganglia	39
culture medium	39
arterial blood	39
gold standard	39
evs isolated	39
lung function	39
old boy	39
gram negative	39
agvhd grade	39
cerebral vasospasm	39
neutropenic fever	39
integrin expression	39
cell populations	38
antifungal prophylaxis	38
time pcr	38
matched donor	38
analyzed using	38
granulocyte macrophage	38
recent years	38
healthy subjects	38
gray matter	38
patient age	38
treatment related	38
safety profile	38
clinical manifestations	38
term survival	38
factor receptor	38
ich patients	38
cord injury	38
second line	38
progenitor cell	38
significantly elevated	38
glasgow outcome	38
family donor	38
mhc class	38
differential centrifugation	38
haploidentical transplant	38
overall response	38
csf treatment	38
survival rates	38
protein expression	38
hemorrhagic shock	38
severe aplastic	38
three times	38
less likely	38
may represent	38
baseline characteristics	38
middle cerebral	38
evs released	37
csf neopterin	37
newly diagnosed	37
younger patients	37
brain parenchyma	37
syncytial virus	37
blood culture	37
disease activity	37
tract infection	37
neutrophil count	37
fold increase	37
animal studies	37
th cells	37
per patient	37
wide range	37
grade iv	37
isolation methods	37
arterial pressure	37
cells infused	37
clinical improvement	37
mean arterial	37
autologous sct	37
hiv infection	37
ich score	37
within months	37
human eosinophils	37
brain stem	37
protective effect	37
icu los	37
tnf production	36
organ damage	36
reactive oxygen	36
potential role	36
transplant patients	36
patients relapsed	36
older patients	36
cell disease	36
subarachnoid space	36
fold higher	36
two weeks	36
hospital admission	36
achieved cr	36
blood count	36
aged years	36
isolated using	36
exact test	36
family members	36
primary endpoint	36
hematoma expansion	36
definitive diagnosis	36
underwent asct	36
odds ratio	36
hsct patients	36
hypereosinophilic syndrome	36
lymphocyte infusion	36
vs days	36
diffuse large	36
measles virus	36
significant association	36
cd positive	36
visual acuity	36
iav infection	36
related toxicity	36
therapeutic option	36
study aimed	36
literature review	36
high doses	36
infectious disease	36
main cause	36
neurological disease	36
receptor antagonist	36
still alive	36
severe cgvhd	36
cns disease	36
remains unclear	36
liver failure	36
febrile neutropenia	36
study included	36
significant risk	35
one week	35
commercially available	35
secondary graft	35
severe traumatic	35
pcr testing	35
low levels	35
tissue injury	35
median dose	35
disclosure background	35
taken together	35
plasma evs	35
first day	35
significantly correlated	35
surface area	35
three months	35
mesenchymal stromal	35
lung tissue	35
viral reactivation	35
hla identical	35
new york	35
related donors	35
ovarian cancer	35
primary graft	35
autoimmune encephalomyelitis	35
chemotherapy followed	35
three different	35
human brain	35
cytokine levels	35
heart failure	35
csf administration	35
therapeutic potential	35
well known	35
see chapter	35
determined using	35
thalassemia major	35
developed severe	35
vod sos	34
induction chemotherapy	34
ml min	34
early detection	34
older age	34
curative option	34
large number	34
human herpesvirus	34
clinically significant	34
real time	34
cell collection	34
simplex virus	34
inflammatory cells	34
three days	34
received hsct	34
motor neuron	34
per kg	34
also showed	34
limited data	34
patient outcomes	34
low risk	34
clinical diagnosis	34
west nile	34
trauma patients	34
significant decrease	34
cells showed	34
molecular mechanisms	34
ev subpopulations	34
surface expression	34
colorectal cancer	34
clinical response	34
host cells	34
leukemia patients	34
infected mice	34
cmv disease	34
small number	34
different types	34
severe covid	34
graft function	34
amyotrophic lateral	34
nd allo	34
haploidentical stem	34
well established	34
group compared	34
lateral sclerosis	34
data suggests	34
chronic myeloid	33
cd depleted	33
study showed	33
immune suppression	33
high incidence	33
continuous infusion	33
rna sequencing	33
human immunodeficiency	33
independent predictor	33
also significantly	33
multivariable analysis	33
health care	33
innate immunity	33
viral encephalitis	33
study shows	33
plasma membrane	33
plasma exchange	33
malignant diseases	33
prospectively collected	33
collected data	33
expression levels	33
wbc count	33
calculated using	33
myeloid leukaemia	33
cns involvement	33
cyclophosphamide mg	33
increased expression	33
medical university	33
control subjects	33
therapeutic strategies	33
replacement therapy	33
icu patients	33
cgvhd patients	33
two days	32
randomized trial	32
blood glucose	32
toxoplasma gondii	32
serum neopterin	32
cryptococcal infection	32
presenting cells	32
vascular endothelial	32
csf pleocytosis	32
trem deficient	32
beneficial effects	32
positive results	32
bal fluid	32
combination therapy	32
clinical significance	32
relapse free	32
second transplant	32
three cats	32
liver function	32
significant impact	32
last years	32
normal csf	32
bk virus	32
cns infections	32
experimental autoimmune	32
acute renal	32
phase iii	32
one month	32
pts died	32
eleven patients	32
outcome scale	32
spf cats	32
showed significant	32
outcome measures	32
disease risk	32
elevated serum	32
patients included	32
pulmonary toxicity	32
may serve	32
csf may	32
transplant outcomes	32
tumour microenvironment	32
dependent manner	32
like receptor	32
life threatening	32
national university	32
autoimmune disease	32
mononuclear cell	31
csf receptor	31
successfully treated	31
general population	31
exclusion criteria	31
multicenter study	31
similar results	31
icu stay	31
enrolled patients	31
central role	31
subdural hematoma	31
salvage treatment	31
achieved complete	31
canine distemper	31
gvhd occurred	31
patients required	31
lymphocyte infusions	31
fi rst	31
refractory acute	31
acute disseminated	31
signal transduction	31
cranial nerve	31
neurological outcome	31
clinical study	31
authors declare	31
broad spectrum	31
next generation	31
cd ro	31
serum glucose	31
delayed cerebral	31
steroid treatment	31
disease course	31
body surface	31
small evs	31
cell communication	31
total nucleated	31
rank test	31
acute encephalitis	31
cell responses	31
following allogeneic	31
allogeneic bone	31
first study	31
clinically relevant	31
patients affected	31
pd patients	31
protein cargo	31
perfusion pressure	31
infected cells	31
cells may	31
stage iii	31
nasal polyposis	30
risk acute	30
blot analysis	30
immunosuppressive treatment	30
transplant period	30
current study	30
fever without	30
donor cells	30
asah patients	30
also known	30
care units	30
another study	30
ab mbp	30
human monocytes	30
pseudomonas aeruginosa	30
tract infections	30
abdominal sepsis	30
analysed using	30
functional outcomes	30
lymph node	30
received allo	30
may reflect	30
protein concentrations	30
studies will	30
tumour growth	30
negative bacteria	30
vitro studies	30
several studies	30
term outcomes	30
steroid refractory	30
better os	30
without fip	30
corpus callosum	30
financial support	30
human granulocyte	30
high morbidity	30
inflammatory monocytes	30
cells per	30
year cumulative	30
mg daily	30
patient presented	30
thermal injury	30
crucial role	30
therapeutic strategy	30
healthy individuals	30
binding protein	30
oxygen saturation	30
trial registry	30
family history	30
surface marker	30
neurological disorders	30
median survival	30
favorable outcome	30
barrier function	29
complete resolution	29
autoimmune encephalitis	29
ml kg	29
female patients	29
hct recipients	29
response rates	29
significant morbidity	29
complete blood	29
cell numbers	29
total rna	29
kg body	29
nucleic acid	29
time course	29
developmental delay	29
linked immunosorbent	29
immune deficiency	29
carotid artery	29
quantitative pcr	29
adaptive immune	29
may present	29
patient showed	29
cell carcinoma	29
exosomes derived	29
lavage fluid	29
early post	29
increased mortality	29
red cell	29
hess grade	29
ev production	29
study population	29
dose therapy	29
nile virus	29
short course	29
quality control	29
salvage chemotherapy	29
using flow	29
per week	29
mobilized peripheral	29
within weeks	29
cerebrovascular disease	29
critical role	29
cardiac output	29
including patients	29
ev numbers	29
antibiotic treatment	29
response syndrome	29
cats without	29
specific antibody	29
gram stain	29
cerebral infarction	28
received allogeneic	28
bacterial translocation	28
developed chronic	28
previously shown	28
elevated csf	28
solid organ	28
following hsct	28
one child	28
disseminated encephalomyelitis	28
treatment options	28
care patients	28
decision making	28
within minutes	28
cell growth	28
inflammatory process	28
beneficial effect	28
significant changes	28
many patients	28
curative therapy	28
performance status	28
age group	28
mri findings	28
infused cd	28
therapy may	28
kidney injury	28
circulating evs	28
major basic	28
university medical	28
intravenous immunoglobulin	28
one third	28
brain imaging	28
high resolution	28
intestinal gvhd	28
cord compression	28
patient cohort	28
patients following	28
biological activity	28
without source	28
eosinophilic myositis	28
fully matched	28
studies using	28
previously published	28
every hours	28
single centre	28
protein markers	28
flow cytometric	28
discharged home	28
mcg ml	28
ii score	28
mds patients	28
different cell	28
study suggests	28
cells transplantation	28
study aims	28
complement activation	28
preparative regimen	28
aneurysmal sah	28
allogeneic transplant	28
jazz pharmaceuticals	28
liver disease	28
aseptic meningitis	28
may benefit	27
late effects	27
conditioning therapy	27
month period	27
donor cell	27
particle size	27
inflammatory processes	27
retrospectively evaluated	27
axonal injury	27
per ml	27
transcranial doppler	27
neutrophilic pleocytosis	27
standard deviation	27
blood transplantation	27
days vs	27
proteomic analysis	27
median interval	27
comatose patients	27
muscle biopsy	27
oligoclonal bands	27
compared using	27
obstruction syndrome	27
palliative care	27
patients infected	27
beam group	27
data regarding	27
engraftment occurred	27
antibody titers	27
two years	27
allograft rejection	27
mechanically ventilated	27
mean time	27
newborn babies	27
burst suppression	27
increased intracranial	27
wistar rats	27
mast cell	27
treated group	27
dc leu	27
male patients	27
research funding	27
positive patients	27
reperfusion injury	27
severe gvhd	27
trauma center	27
showed significantly	27
without significant	27
ethics committee	27
treatment group	27
severe brain	27
advanced disease	27
second patient	27
better outcome	27
cell receptor	27
evidence suggests	27
early stage	27
gi tract	27
new therapeutic	27
improve outcomes	27
transforming growth	27
tumour progression	27
seasonal influenza	27
pathway analysis	27
positive correlation	27
month follow	27
olfactory sensory	27
i ii	27
side effect	27
peripheral nervous	27
multiorgan failure	27
acute encephalopathy	27
identify patients	27
data collection	27
cryptococcal antigen	26
tertiary care	26
post asct	26
oxygen species	26
lymphocyte count	26
patients whose	26
venous blood	26
blood transfusion	26
trend toward	26
entire cohort	26
midline shift	26
chemokine receptor	26
patient underwent	26
epithelial cell	26
neurodegenerative diseases	26
multivariable logistic	26
th day	26
progressive ms	26
adipose tissue	26
severe neutropenia	26
cell recovery	26
centre experience	26
upper respiratory	26
analyzed patients	26
immunosorbent assay	26
strongly associated	26
dnase activity	26
vasogenic edema	26
arterial hypertension	26
prognostic factor	26
may show	26
staphylococcus aureus	26
ich volume	26
hypoxic respiratory	26
total dose	26
evoked potentials	26
differential expression	26
inflammatory cytokine	26
times higher	26
potential therapeutic	26
high rate	26
inflammatory disease	26
single dose	26
potentially curative	26
ventricular drain	26
matter lesions	26
less common	26
cells expressing	26
patient group	26
patients suffered	26
age groups	26
data support	26
scoring system	25
alternative donor	25
randomized controlled	25
chimeric antigen	25
cd dose	25
cellular uptake	25
renal disease	25
acute stroke	25
severe cases	25
cells treated	25
sinusoidal obstruction	25
producing cells	25
small sample	25
family donors	25
laboratory tests	25
clinical deterioration	25
poor graft	25
biological activities	25
autosomal recessive	25
alveolar epithelial	25
mechanisms underlying	25
placebo group	25
national institutes	25
time period	25
flow cytometer	25
national institute	25
intervertebral disc	25
electronic medical	25
year survival	25
mri scans	25
may explain	25
neutrophil counts	25
short term	25
acute necrotizing	25
regression models	25
significantly greater	25
steroid therapy	25
longer follow	25
hospital day	25
virus infections	25
fatty acids	25
studied patients	25
urinary neopterin	25
eosinophil infiltration	25
granule proteins	25
first dose	25
monocyte differentiation	25
post sct	25
complete donor	25
eosinophils may	25
overall mortality	25
eosinophil recruitment	25
optic nerve	25
antiviral therapy	25
absolute neutrophil	25
medical management	25
novel therapeutic	25
parenteral nutrition	25
blood vessels	25
weight gain	25
post transplantation	25
first complete	25
like receptors	25
cell lung	25
likely due	25
lymphocytic leukemia	25
sensory neurons	25
improved survival	25
survival time	25
immune function	25
rat model	24
well understood	24
induced neutropenia	24
average age	24
dose melphalan	24
neurological diseases	24
hematological recovery	24
wide variety	24
twelve patients	24
neutrophil extracellular	24
neuro icu	24
major complication	24
early stages	24
times per	24
common complication	24
reconstitution inflammatory	24
vivo studies	24
interquartile range	24
blood monocytes	24
acute onset	24
systolic blood	24
unknown origin	24
second hsct	24
oral mucositis	24
least two	24
hazard ratio	24
comorbidity index	24
system involvement	24
drug resistance	24
imaging findings	24
one hour	24
mainly due	24
human peripheral	24
membrane vesicles	24
haematological malignancies	24
poor mobilizers	24
leukemic cells	24
spontaneous ich	24
pivotal role	24
demyelinating disease	24
paediatric neurology	24
cox regression	24
years ago	24
hospitalized patients	24
also increased	24
first month	24
intermediate risk	24
macrophage activation	24
ecp treatment	24
donor source	24
male female	24
first months	24
analysis using	24
liposomal amphotericin	24
age range	24
standard therapy	24
major role	24
cell number	24
published data	24
outcome measure	24
inflammatory syndrome	24
trem deficiency	24
often associated	24
examination showed	24
eligible patients	24
chronic lymphocytic	24
brain showed	24
feline coronavirus	24
opening pressure	24
therapeutic approaches	24
csf group	24
adverse event	24
linear regression	24
steady state	24
assess whether	24
influenza infection	24
transverse myelitis	24
samples collected	24
viral replication	24
muscle cells	24
per year	24
unrelated cord	24
host response	24
organ injury	24
cell replete	24
serum albumin	24
kinase inhibitors	24
patients requiring	24
may improve	24
remains unknown	24
lymphocyte subsets	24
days prior	24
body fluids	24
patient groups	24
average time	24
selected patients	24
clinical background	23
better understanding	23
young patients	23
protein level	23
disease caused	23
center study	23
skin lesions	23
may manifest	23
nerve conduction	23
mildly elevated	23
antigen presentation	23
several days	23
cell differentiation	23
cik cells	23
uric acid	23
successful treatment	23
eosinophilic inflammation	23
received peripheral	23
results obtained	23
coronavirus infection	23
patients also	23
abstract already	23
lower incidence	23
young children	23
serum il	23
group vs	23
better understand	23
adoptive transfer	23
conventional chemotherapy	23
currently available	23
group patients	23
calcineurin inhibitors	23
higher rate	23
molecular weight	23
days following	23
engraftment failure	23
fluid analysis	23
associated encephalopathy	23
increased incidence	23
lower extremity	23
cell reconstitution	23
hunt hess	23
following treatment	23
randomized clinical	23
nasopharyngeal swab	23
organ donation	23
human plasma	23
heat shock	23
outcome data	23
years post	23
cytotoxic activity	23
colonystimulating factor	23
treatment strategies	23
ad mouse	23
active infection	23
high grade	23
independent risk	23
relapsed disease	23
choroid plexus	23
better outcomes	23
cerebral venous	23
previous study	23
chronic inflammatory	23
chronic rhinosinusitis	23
levels increased	23
therapeutic effect	23
highly sensitive	23
investigate whether	23
peritoneal macrophages	23
disease process	23
outer membrane	23
gene therapy	23
iu ml	23
melanoma cells	23
provide evidence	23
data demonstrate	23
clinical findings	23
exosomes isolated	23
barre syndrome	23
particles ml	23
multivariate logistic	23
clinical information	23
respiratory viruses	23
lymphocytic pleocytosis	23
already published	23
control patients	23
good partial	23
culture system	23
tumour cell	23
higher rates	23
donor age	23
acute liver	23
room temperature	23
algan gan	23
hematopoetic stem	23
first patient	23
burn injury	23
nasal polyp	23
three cases	23
early phase	23
three pts	22
temporal lobe	22
acute kidney	22
ev preparations	22
treatment modality	22
groups according	22
protein synthesis	22
limited number	22
aplastic anaemia	22
gcs score	22
standard treatment	22
different time	22
year follow	22
associated pneumonia	22
cell products	22
normal saline	22
thrombotic microangiopathy	22
using standard	22
year post	22
times daily	22
tumor cell	22
retrospectively analysed	22
based regimen	22
female patient	22
interim analysis	22
extracellular traps	22
atrial fibrillation	22
seven days	22
lps challenge	22
mg twice	22
neurological exam	22
neurointensive care	22
received dli	22
controlled study	22
mesenteric lymph	22
posterior reversible	22
analysis identified	22
sodium chloride	22
results confirm	22
allogenic hematopoietic	22
diagnostic yield	22
negative sepsis	22
cell survival	22
sepsis syndrome	22
also shown	22
higher cd	22
treated animals	22
glial cells	22
cox proportional	22
expression level	22
post allo	22
consecutive adult	22
ev protein	22
cells mm	22
chemotherapy alone	22
may act	22
least days	22
two pts	22
remained stable	22
control groups	22
evs may	22
acute hypoxic	22
clinical setting	22
quality improvement	22
diagnostic tests	22
liver toxicity	22
treated mice	22
oxygen tension	22
tissue repair	22
encephalitis associated	22
event free	22
single ev	22
kg iv	22
free radicals	22
male patient	22
agvhd patients	22
undergoing allo	22
primary immunodeficiency	22
hydrogen peroxide	22
cell infusion	22
ct head	22
suspected meningitis	22
normal human	22
brain biopsy	22
liver enzymes	22
research center	22
blood loss	22
genetic testing	22
adult respiratory	22
independent predictors	22
gel electrophoresis	22
derived ev	22
inflammatory bowel	21
molecular remission	21
iii iv	21
serum sodium	21
effector functions	21
hematologic diseases	21
acute pancreatitis	21
adaptive immunity	21
developed cmv	21
apnea test	21
fip cats	21
invasive mechanical	21
relapse rates	21
th percentile	21
well described	21
genomic dna	21
phase study	21
five days	21
rating scale	21
higher mortality	21
phase proteins	21
body mass	21
one day	21
plasma concentrations	21
diffusion restriction	21
venous catheter	21
study will	21
olfactory bulb	21
frontal lobe	21
encephalitis virus	21
brain ct	21
macrophage polarization	21
allergen challenge	21
reduced toxicity	21
apnea testing	21
expression analysis	21
tumor growth	21
based regimens	21
drug delivery	21
viral rna	21
serious adverse	21
human metapneumovirus	21
cell cultures	21
specific immune	21
associated acute	21
blood eosinophilia	21
low incidence	21
icp monitoring	21
mrd group	21
new onset	21
cmv viremia	21
blood contamination	21
also used	21
pet ct	21
heavily pretreated	21
neurologic symptoms	21
longer time	21
cancer center	21
white cell	21
invasive aspergillosis	21
platelet counts	21
higher doses	21
systemic lupus	21
lower gi	21
ev proteins	21
heart disease	21
neurologic manifestations	21
received either	21
cells compared	21
final concentration	21
endothelial damage	21
showed increased	21
positive csf	21
investigated whether	21
review board	21
institutional review	21
continuous eeg	21
intensive chemotherapy	21
stimulating factors	21
early mortality	21
induced lung	21
cells using	21
nhl patients	21
frequently used	21
endovascular treatment	21
control animals	21
evs showed	21
normal controls	21
cd ratio	21
hours prior	21
blood brain	21
group will	21
polysaccharide antigen	21
systemic inflammation	21
transgenic mice	21
pao fio	21
protective effects	21
head trauma	21
risk cytogenetics	21
risk aml	21
cumulative incidences	21
ev populations	21
guinea pigs	21
culture conditions	21
also demonstrated	21
ev surface	21
without evidence	21
hematopoietic recovery	21
lactate dehydrogenase	21
lupus erythematosus	21
serious complication	21
conditioned patients	21
neurological dysfunction	21
additional studies	21
clinical applications	21
absolute number	21
randomized study	21
past medical	20
also associated	20
immune recovery	20
transplant characteristics	20
end point	20
exosome secretion	20
signaling pathway	20
induction treatment	20
increased il	20
syndrome associated	20
coronary artery	20
high level	20
airway inflammation	20
worse outcomes	20
written informed	20
sputum eosinophils	20
small cell	20
severe infections	20
seizure frequency	20
probably due	20
receptor expression	20
whole lung	20
csf mrna	20
lower respiratory	20
transplant complications	20
dr expression	20
severe complication	20
movement disorders	20
brain lesions	20
syphilitic gumma	20
johns hopkins	20
markers cd	20
antigen receptor	20
naturally occurring	20
patients enrolled	20
preemptive therapy	20
early death	20
hsct setting	20
may develop	20
displaying pep	20
prospective cohort	20
years overall	20
arterial verapamil	20
transplant outcome	20
positively correlated	20
received chemotherapy	20
severe disease	20
small rnas	20
specific cd	20
years later	20
control mice	20
spinal trauma	20
larger studies	20
converting enzyme	20
alveolar macrophage	20
tested positive	20
vital signs	20
cancer institute	20
optic neuritis	20
possible role	20
myelogenous leukemia	20
rabbit atg	20
primary refractory	20
patients responded	20
increased numbers	20
retrospective case	20
human disease	20
relapse risk	20
autologous transplant	20
pts receiving	20
clinical condition	20
neutrophil elastase	20
hospital los	20
every weeks	20
signalling pathways	20
reversible encephalopathy	20
eosinophilic infiltration	20
underwent autologous	20
spinal fluid	20
pulse sensing	20
inflammatory csf	20
severe combined	20
early intervention	20
soft tissue	20
cmv dna	20
higher number	20
cytogenetic risk	20
hemorrhagic stroke	20
autologous blood	20
asthmatic subjects	20
clinical use	20
prospective randomized	20
glucose levels	20
thirteen patients	20
will help	20
cell migration	20
secondary progressive	20
killer cells	20
study demonstrates	20
increasingly used	20
evd placement	20
gvhd patients	20
analysis included	20
patients submitted	20
tissue oxygen	20
using anti	20
last decade	20
organ transplant	20
differ significantly	20
temperature management	20
rabbit anti	20
group received	20
spectrum antibiotics	20
promising results	20
injury severity	20
icu length	20
data collected	20
human coronavirus	20
cns inflammation	20
significant change	20
tissue samples	20
high affinity	20
mean number	20
studies demonstrated	20
blood levels	20
oxide synthase	20
exome sequencing	20
evaluated using	20
cd selected	20
immunosuppressive agents	20
confocal microscopy	20
refractory gvhd	20
csf overexpression	20
inflammatory demyelinating	20
size range	20
tumour necrosis	20
ab tmev	20
kinase inhibitor	20
blood sample	20
donor recipient	20
fluorescence microscopy	19
ev secretion	19
posterior circulation	19
transcription levels	19
ev samples	19
bu cy	19
antigen presenting	19
colony forming	19
primary diagnosis	19
neurological association	19
great ormond	19
related toxicities	19
large evs	19
allo hsct	19
muscle weakness	19
normal values	19
csf strem	19
developed agvhd	19
based gvhd	19
inflammatory reaction	19
enterovirus pcr	19
data showed	19
therapeutic efficacy	19
observational cohort	19
necrotizing encephalopathy	19
may affect	19
complete recovery	19
relapsed aml	19
hi monocytes	19
positive control	19
remission status	19
young people	19
csf alone	19
often used	19
surviving patients	19
studies show	19
primary objective	19
frequent complication	19
neurologic disease	19
dose dependent	19
threatening complication	19
useful tool	19
affected cats	19
except one	19
relatively high	19
pulmonary disease	19
infection may	19
may influence	19
ormond street	19
high prevalence	19
may produce	19
transcription factors	19
severe respiratory	19
patient experienced	19
gvhd incidence	19
treatment failure	19
high expression	19
fully understood	19
associated proteins	19
plerixafor group	19
early relapse	19
motor function	19
blood stream	19
dose cyclophosphamide	19
csf showed	19
infectious agents	19
cd evs	19
highly variable	19
fourteen patients	19
lumbar csf	19
cell sources	19
muscular dystrophy	19
autologous hct	19
blood donors	19
alkaline phosphatase	19
major histocompatibility	19
one pt	19
hematological diseases	19
matrix metalloproteinase	19
kidney disease	19
control study	19
post hct	19
human patients	19
will also	19
chest radiograph	19
brain injured	19
severe agvhd	19
evaluable patients	19
biopsy specimens	19
haploidentical hematopoietic	19
lower limbs	19
circulating neutrophils	19
care society	19
plasma cells	19
blood eosinophils	19
single cell	19
every months	19
ev size	19
factors may	19
function tests	19
american neurological	19
host immune	19
contrast enhancement	19
high sensitivity	19
spot sign	19
many studies	19
healthy donor	19
restricted diffusion	19
ventilated patients	19
eosinophil numbers	19
weeks post	19
statistical difference	19
also reported	19
mud mmud	19
recently published	19
hematopoietic cells	19
increased icp	19
treatment groups	19
younger age	19
refractory aml	19
patients years	19
treated cells	19
identified using	19
neutrophil survival	19
wt mice	19
hemophagocytic lymphohistiocytosis	19
target temperature	19
systemic treatment	19
better survival	19
complications associated	19
graft vs	19
cardiovascular disease	19
median overall	19
consolidation therapy	19
blood group	19
resistive pulse	19
biological fluids	19
correlation coefficient	19
scan showed	19
imaging studies	19
plga nanoparticles	19
cell membrane	19
culture supernatant	19
csf culture	19
observation period	19
kg i	19
blood products	18
respiratory virus	18
liquid chromatography	18
plasma cell	18
significant predictors	18
two decades	18
medical record	18
young adults	18
received mg	18
total evs	18
internal carotid	18
hepatocellular carcinoma	18
may offer	18
gi gvhd	18
prospective observational	18
borrelia burgdorferi	18
lesser extent	18
reactivation occurred	18
national cancer	18
neuronal cells	18
signalling pathway	18
therapeutic target	18
will receive	18
blood transfusions	18
ko mice	18
treatment strategy	18
situ hybridization	18
cecal ligation	18
among others	18
highly expressed	18
prospectively enrolled	18
stroke center	18
clinical evaluation	18
results will	18
may require	18
patient relapsed	18
ventricular system	18
significant effect	18
internal medicine	18
sinus thrombosis	18
significant proportion	18
bovine serum	18
treatment response	18
purified evs	18
multiple trauma	18
sars coronavirus	18
virus type	18
platelet activation	18
risk score	18
auto hsct	18
eosinophil cationic	18
arrest patients	18
msc evs	18
vascular smooth	18
bowel disease	18
cell cycle	18
rights reserved	18
three weeks	18
allogenic hsct	18
results support	18
surgical decompression	18
effective therapy	18
diabetes mellitus	18
platelet transfusions	18
different ev	18
csf serum	18
different levels	18
adverse reactions	18
ev biogenesis	18
endotracheal tube	18
vascular endothelium	18
cell activity	18
lung disease	18
risk features	18
good response	18
decompressive hemicraniectomy	18
four cats	18
respiratory insufficiency	18
mortality due	18
mediated immunity	18
ms ms	18
initial presentation	18
los angeles	18
may indicate	18
data analysis	18
rare complication	18
without atg	18
decreased expression	18
clinical management	18
largely unknown	18
encephalopathy syndrome	18
least months	18
much less	18
plasminogen activator	18
group i	18
idiopathic eosinophilic	18
many different	18
significant clinical	18
recent data	18
low level	18
oxygen delivery	18
pulmonary edema	18
pb cd	18
late onset	18
high concentrations	18
corticosteroid therapy	18
may increase	18
first week	18
increased significantly	18
dna damage	18
public health	18
detection limit	18
eosinophil counts	18
unclear whether	18
lewis rats	18
septic complications	18
will provide	18
refractory patients	18
venous access	18
patients met	18
high index	18
four weeks	18
weighted imaging	18
drug interactions	18
improve survival	18
previous reports	18
homing peptide	18
multicenter trial	18
primary infection	18
progressive multiple	18
last dose	18
organ involvement	17
intraparenchymal hemorrhage	17
expression profile	17
hours following	17
signaling pathways	17
clinical samples	17
patients survived	17
previously healthy	17
grade sah	17
hepatic encephalopathy	17
ev uptake	17
cationic protein	17
inhibitory effect	17
nonrelapse mortality	17
skin involvement	17
ct angiogram	17
two months	17
lesions may	17
specific markers	17
commonly seen	17
treatment may	17
cd antibody	17
hematological disorders	17
blood progenitor	17
daily dose	17
electrographic seizures	17
signal intensity	17
weeks later	17
markedly increased	17
per month	17
ccr expression	17
autologous pbsct	17
significant cause	17
csf antibodies	17
nmda receptor	17
therapeutic options	17
rare cases	17
induced asthma	17
matched controls	17
visual loss	17
phagocytic cells	17
examination revealed	17
infected animals	17
venous thrombosis	17
may induce	17
poor quality	17
cell mediated	17
peripheral neuropathy	17
risk stratification	17
pts developed	17
specific igg	17
systemic signs	17
children undergoing	17
received bone	17
receptor signaling	17
three years	17
meier method	17
refractory agvhd	17
group consisted	17
days respectively	17
comparative analysis	17
malignant lymphoma	17
crp levels	17
acute myelogenous	17
neoplastic cells	17
obstructive hydrocephalus	17
mechanical thrombectomy	17
genetic material	17
csf cultures	17
primary disease	17
potential biomarkers	17
pediatric hsct	17
mrna levels	17
kg hr	17
major surgery	17
miltenyi biotec	17
csf igg	17
brentuximab vedotin	17
blood counts	17
japanese encephalitis	17
trem variant	17
placebo controlled	17
free radical	17
ric regimen	17
rankin score	17
elevated neopterin	17
medical treatment	17
baseline values	17
pbsc collection	17
patients developing	17
showed higher	17
day period	17
cognitive function	17
central line	17
disc disease	17
good outcomes	17
log rank	17
cancer progression	17
early recognition	17
clinical variables	17
sct group	17
hsct using	17
clinical picture	17
immune modulation	17
cell response	17
admission gcs	17
donor lymphocytes	17
microglial cells	17
categorical variables	17
evs secreted	17
whole cohort	17
therapeutic intervention	17
mumps virus	17
cells within	17
retrospectively collected	17
gradient centrifugation	17
negative patients	17
increased serum	17
urine samples	17
demographic data	17
report two	17
neuromyelitis optica	17
antiretroviral therapy	17
related death	17
brain damage	17
machine learning	17
cell evs	17
derived macrophages	17
may reduce	17
oxygen radicals	17
novel approach	17
triple negative	17
highly effective	17
medical school	17
decreased significantly	17
soluble trem	17
radiation therapy	17
peripheral eosinophilia	17
ewing sarcoma	17
patients due	17
myeloid malignancies	17
human blood	17
health status	17
analyzed data	17
renal cell	17
transplantation cyclophosphamide	17
severe head	17
cd lymphocytes	17
vascular resistance	17
expression patterns	17
eeg patterns	17
hospital course	17
aml mds	17
donor transplant	16
important cause	16
chronic renal	16
significant role	16
gradient ultracentrifugation	16
negative control	16
cell grafts	16
cellular immune	16
adv infection	16
prospective trials	16
surgical procedures	16
cytometry using	16
closely related	16
leukemia cells	16
pulmonary complications	16
brain cells	16
whereas patients	16
neutropenic patients	16
flow filtration	16
previous treatment	16
using two	16
ejection fraction	16
motif chemokine	16
mortality associated	16
see table	16
renal insufficiency	16
thiamine deficiency	16
vast majority	16