Questions

This is a list of all the questions and their associated study carrel identifiers. One can learn a lot of the "aboutness" of a text simply by reading the questions.

identifier question
cord-016292-o4cw5ufya challenge for the veterinary profession Is that a rodent in your luggage?
cord-002957-gw2cow0dThe Veterinary clinics of North America Food animal practice Comparison of cytokine measurements using ELISA, ELISPOT and semi- quantitative RT- PCR Differentiation of C- strain"Riems"or CP7_E2alf vaccinated animals from animals infected by classical swine fever virus field strains using real- time RT- PCR Escape of classical swine fever Cstrain vaccine virus from detection by C- strain specific real- time RT- PCR caused by a point mutation in the primer- binding site Laboratory test descriptions for bovine respiratory disease diagnosis and their strengths and weaknesses: Gold standards for diagnosis, do they exist?
cord-009381-q9s38fkhWhich BVD vaccine should I use?
cord-017955-oipail5lWorking Group criteria for codifying the site of inflammation appropriate for all uveitis problems?
cord-018566-dd5gw66tThe landscape of antibiotic resistance Prepared for United States Department of Health and Human Services, Public Health Service, Food and Drug Administration, Bureau of Veterinary Medicine Prudent use and regulatory guidelines for veterinary antibiotics- politics or science?
cord-018145-kssjdn8yIntracellular immunization: a new strategy for producing diseaseresistant transgenic livestock?
cord-254559-3kgfwjzdWhy do farmers and veterinarians not report all bovine abortions, as requested by the clinical brucellosis surveillance system in France?
cord-285628-36gyix12National Association of State Public Health Veterinarians Veterinary Infection Control Committee Infection control practices and zoonotic disease risks among veterinarians in the United States Evaluation of specific infection control practices used by companion animal veterinarians in community veterinary practices in southern Ontario Evaluation of an educational campaign to increase hand hygiene at a small animal veterinary teaching hospital Does improving surface cleaning and disinfection reduce health care- associated infections?
cord-254264-jkug3jpzOf interest from the point of speculation would be the question that if an early disease detection system, perhaps employing an infrared parameter, were possible, what then would be the optimal way to utilize such data?
cord-022383-pz0htccpExcre tion and transmission of virus occurs via the respiratory tract( Jacoby
cord-021453-vf8xbaugDirofilaria immitis: Do filarial cyclooxygenase products depress endothelium- dependent relaxation in the in vitro rat aorta?
cord-018404-jdu4h00eQuestions and answers on monoclonal antibodies for veterinary use European Medicines Agency Allergic disorders and IgE- mediated immune responses: where do we stand?
cord-018404-jdu4h00eWhy do we need IgM memory B cells?
cord-023367-ujflw19bin goats farmed under resource- poor conditions in South Africa using an eye colour chart developed for sheep Validation of the FAMA- CHA eye color chart for detecting clinical anemia in sheep and goats on farms in the southern United States Validation of the FAMACHA © eye colour chart using sensitivity/ specificity analysis on two South African sheep farms Is the FAMACHA chart suitable for every breed?
cord-022219-y7vsc6r7Is there a specific immunologie reaction by these cells toward uveal antigens that is important in the production of human endogenous uveitis, or is the reactivity observed merely as an epiphenomenon?
cord-022219-y7vsc6r7JC polyoma virus was injected into the eyes of newborn hamsters by Ohashi and his associates( 1978); 20% of the animals developed retinoblastoma- or ependymoblastoma- like intraocular tumors 7 Vi-\?
cord-275959-mat7ul7cPerspectives for the future in Italy: animal science higher education, employment and research Animal science program accreditation?
cord-266746-c0urbl6lcan we feed the world and sustain the planet?
cord-265299-oovkoiyjThe long view: a bright past, a brighter future?
cord-293079-z7dx6ey9The epidemiology of bovine respiratory disease: What is the evidence for predisposing factors?
cord-009729-69swjzicScientific Opinion on the public health hazards to be covered by inspection of meat( poultry) Reducing the future threat from( liver) fluke: realistic prospect or quixotic fantasy?
cord-009729-69swjzicWHO/ JECFA monographs 8, WHO Determination of colchicine residues in sheep serum and milk using high- performance liquid chromatography combined with electrospray ionization ion trap tandem mass spectrometry Depletion of protein- bound furazolidone metabolites containing the 3-amino-2-oxazolidinone side- chain from liver, kidney and muscle tissues from pigs Formation of semicarbazide( SEM) in food by hypochlorite treatment: is SEM a specific marker for nitrofurazone abuse?
cord-009583-ldkjqco6I asked,"Why the funny look?"
cord-009583-ldkjqco6Should there be more scanning and identification of futureproofing policies?
cord-009583-ldkjqco6While you're taking care of an emergency, who's taking care of you?
cord-001427-qw1e5cofMethicillin- resistant Staphylococcus aureus in animals Does broad- spectrum β- lactam resistance due to NDM-1 herald the end of the antibiotic era for treatment of infections caused by Gram- negative bacteria?
cord-001427-qw1e5cofThe European Union summary report on trends and sources of zoonoses, zoonotic agents and food- borne outbreaks in 2011 Fecal carriage and shedding density of CTX- M extended- spectrum ß- lactamaseproducing Escherichia coli in cattle, chickens, and pigs: implications for environmental contamination and food production Emergence of methicillin- resistant Staphylococcus aureus( MRSA) in different animal species Methicillin- resistant Staphylococcus aureus in food products: cause for concern or case for complacency?
cord-001427-qw1e5cofThe components of'One World-One Health'approach Animal associated opportunistic infections among persons infected with the human immunodeficiency virus Biofilms in oral cavity of dogs and implication in zoonotic infections Sensitive populations: who is at the greatest risk?
cord-001427-qw1e5cofThe emergence of Lyme disease Vector transmission of Bartonella species with emphasis on the potential for tick transmission Concurrent infection of the central nervous system by Borrelia burgdorferi and Bartonella henselae: evidence for a novel tick- borne disease complex Cat scratch disease and arthropod vectors: more to it than a scratch?
cord-022393-s26d54ewA new zoonosis?
cord-022393-s26d54ewIn Principles and practices of infectious diseases Laboratory animal allergy in a pharmaceutical company Important animal allergens are lipocalin proteins: why are they allergenic?
cord-286050-l7868xqiWe ask why does it persist if it's so easy to control?
cord-267671-ys43n672Veterinary Microbiology and Microbial Disease Uteroovarian infection in aged B6C3F1 mice Breast cancer: should gastrointestinal bacteria be on our radar screen?
cord-009694-e59kuwf1A field trial evaluating the influence of prophylactic and therapeutic antibiotic administration on antibiotic resistance in fecal Escherichia coli in dairy calves Cryptosporidium parvum, Giardia intestinalis and other enteric pathogens in Swedish dairy calves Role of oxytocin in glucose homeostasis and weight gain Iron- deficiency anaemia in calves Endocrine and metabolic aspects in milk- fed calves Nutritional physiology of neonatal calves Grouping and social preferences in calves, heifers and cows Emotional reactivity affected by chronic stress: an experimental approach in calves submitted to environmental instability Is gentling by people rewarding for beef calves?
cord-009694-e59kuwf1The Effects of Feeding Method, Milk Allowance and Social Factors on Milk Feeding Behaviour and Cross- Sucking in Group Housed Dairy Calves Computer- controlled milk feeding of dairy calves: the effects of number of calves per feeder and number of milk portions on use of feeder and social behaviour Who needs'behavioural needs'?
cord-009694-e59kuwf1key to assessment of animal well- being?
cord-311260-eyvaazfj( mean?
cord-273993-rkqijcxnHow would the future of farm animals be with novel production traits, with resistance to transmissible diseases, or even with the eradication of pests that have harmed livestock throughout the history?
cord-273993-rkqijcxnIs gene editing an acceptable alternative to castration in pigs?
cord-268142-lmkfxme5: what is it, why is it important, and how can we detect it?
cord-268142-lmkfxme5Should we follow the White Rabbit?
cord-277265-p8pns7r9Novel single gold nanowire- based electrochemical immunosensor for rapid detection of bovine viral diarrhoea antibodies in serum Development of a recombinase polymerase amplification assay for detection of epidemic human noroviruses Comparison of the oral microbiomes of canines and their owners using next- generation sequencing Identification of gastroenteric viruses by electron microscopy using higher order spectral features Aptasensors À the future of biosensing?
cord-277265-p8pns7r9The pet connection: pets as a conduit for social capital?
cord-281512-79g22dk6Are Bats Special?
cord-281512-79g22dk6As the world continues to struggle with the unprecedented ramifications of COVID-19, two central questions are being asked: Where did this novel virus come from and how can we prevent future pandemics?
cord-307067-cpc1yefjA phase I trial evaluating the safety and immunogenicity of a candidate tuberculosis vaccination regimen, ChAdOx1 85A prime-MVA85A boost in healthy UK adults Safety and immunogenicity of a heterologous prime- boost ebola virus vaccine regimen in healthy adults in the united kingdom and senegal Middle East respiratory syndrome coronavirus( MERS- CoV) causes transient lower respiratory tract infection in rhesus macaques MERS- CoV spillover at the camel- human interface Recovery from the Middle East respiratory syndrome is associated with antibody and T- cell responses Bactrian camels shed large quantities of Middle East respiratory syndrome coronavirus( MERS- CoV) after experimental infection Absence of MERS- CoV antibodies in feral camels in Australia: Implications for the pathogen's origin and spread Middle East respiratory syndrome coronavirus antibodies in Dromedary Camels Serologic evidence for MERS- CoV infection in Dromedary Camels Molecular evolution of MERS coronavirus: Dromedaries as a recent intermediate host or long- time animal reservoir?
cord-337028-8fh4pe3iUreaplasma urealyticumharmless commensal or underestimated enemy of human reproduction?
cord-262336-onghrm7yIs the animal part of a zoologic collection, is it from a commercial operation, or will it be released back to the wild?
cord-262336-onghrm7yOne of the most common questions a veterinarian may encounter regarding reptiles is"What is the difference between alligators and crocodiles?"
cord-320283-nkb9nzytEscaping Pandora's box: another novel coronavirus Johns Hopkins Coronavirus Resource Center Are we facing a crashing wave of neuropsychiatric sequelae of COVID-19?
cord-282101-2usqpy2j: what's in it for us?
cord-282101-2usqpy2jIn vitro and in vivo antifungal activity of amphotericin B lipid complex: are phospholipases important?
cord-326873-11jgusovInfluenza Other Respir Viruses Pandemic influenza planning: should n't swine and poultry workers be included?
cord-349392-r71g2e9yLaboratory diagnosis of four recent sporadic cases of community- acquired SARS Pathology of guinea pigs experimentally infected with a novel reovirus and coronavirus isolated from SARS patients Animal- to- human SARS- associated coronavirus transmission?
cord-345717-ktajrf7dEmerging Infectious Disease Bushmeat Hunting, Deforestation, and Prediction of Zoonotic Disease Wet markets- a continuing source of severe acute respiratory syndrome and influenza?
cord-312807-8v4r9jijA comparison of bats and rodents as reservoirs of zoonotic viruses: Are bats special?
cord-312807-8v4r9jijWhy has zoonotic tuberculosis not received much attention?
cord-319044-5otz2w9vWhence the next pandemic?
cord-017154-h8hxroosA one health framework for estimating the economic costs of zoonotic diseases on society Risk of importing zoonotic diseases through wildlife trade, United States Does the use of antibiotics in food animals pose a risk to human health?
cord-017154-h8hxroosSustainable farming: get pigs off antibiotics Changes in the use of antimicrobials and the effects on productivity of swine farms in Denmark Integrating genomebased informatics to modernize global disease monitoring, information sharing, and response Vancomycin- resistant enterococci: why are they here, and where do they come from?
cord-017154-h8hxroosThe same prion strain causes vCJD and BSE Decline in the incidence of BSE in cattle born after the introduction of the'feed ban'Analyses of livestock production, waste storage, and pathogen levels and prevalences in farm manures Comment on: does the use of antibiotics in food animals pose a risk to human health?
cord-017154-h8hxrooswhere do we stand?
cord-277573-g3z3gq1mThe ecology of naked mole rat colonies: burrowing, food, and limiting factors Is the naked mole rat Heterocephalus glaber an endothermic yet poikilothermic mammal?
cord-277573-g3z3gq1mWhy do naked mole rats lack pain from chemical irritants?
cord-277573-g3z3gq1mbreaking the one- half rule Is vitamin D 3 essential for mineral metabolism in the damara mole rat( Cryptomys damarensis)?
cord-277573-g3z3gq1mexhibit spontaneous or induced ovulation?
cord-325273-w79fnkq1The Harderian gland, its secretory duct and porphyrin content in the Mongolian gerbil( Meriones unguiculatus) Does the gerbil model mimic human iron overload?
cord-325273-w79fnkq1What's your diagnosis?
cord-352123-0bflqj1cPotential role for zoonotic spread of COVID-19 in older adults?
cord-352123-0bflqj1ce w Y o rk Dogs caught coronavirus from their owners, genetic analysis suggests Infection of dogs with SARS- CoV-2 Vertebral heart scores in eight dog breeds Ferret models of viral pathogenesis SARS- CoV-2 is transmitted via contact and via the air between ferrets Infection and rapid transmission of SARS- CoV-2 in ferrets Coronavirus rips through Dutch mink farms, triggering culls Minipigs and potbellied pigs as pets in the veterinary practice- a retrospective study Comparison of severe acute respiratory syndrome coronavirus 2 spike protein binding to ACE2 receptors from human, pets, farm animals, and putative intermediate hosts Coronavirus disease 2019( COVID-19) outbreak: could pigs be vectors for human infections?
cord-305501-srq1bo2vFurther evidence that deltamethrin- impregnated collars protect domestic dogs from sandfly bites Protection of dogs from bites of phlebotomine sandflies by deltamethrin collars for control of canine leishmaniasis Are insecticide- impregnated dog collars a feasible alternative to dog culling as a strategy for controlling canine visceral leishmaniasis in Brazil?
cord-305501-srq1bo2vLeishmaniasis become endemic in the US?
cord-305501-srq1bo2vSensitivity of malaria, schistosomiasis and dengue to global warming Is heartworm disease really spreading in Europe?
cord-289605-gvc673ijOKAY?].
cord-289605-gvc673ijOptical imaging devices, which allow the user to monitor gene expression[ AUTHOR: EDIT OKAY?]
cord-289605-gvc673ijWhat imaging modalities do they have?
cord-289605-gvc673ijWhat problems have they encountered, and how did they solve them?
cord-293151-g3758oes: what is the correct value for the calculation of metabolic body weight in dogs?
cord-293151-g3758oesAn emerging pulmonary haemorrhagic syndrome in dogs: similar to the human leptospiral pulmonary haemorrhagic syndrome?
cord-293151-g3758oesWhat's your diagnosis?
cord-293151-g3758oesa retrospective study Canine cutaneous epitheliotropic T- cell lymphoma: a review Canine infectious respiratory disease Helicobacter- associated gastric disease in ferrets, dogs, and cats Enteric bacterial infections Hemorrhagic streptococcal pneumonia in newly procured research dogs Association between canine malignant lymphoma, living in industrial areas, and use of chemicals by dog owners Reproductive patterns in the domestic dog- a retrospective study of the Drever breed The dog as a research subject A review of canine pseudocyesis Leptospirosis Surgical treatment of an elbow hygroma utilizing microvascular free muscle transfer in a newfoundland Bacterial diseases Immunoprophylaxis Leptospirosis Gastric helicobacters in domestic animals and nonhuman primates and their significance for human health Non- Helicobacter pylori Helicobacter species in the human gastric mucosa: a proposal to introduce the terms H. heilmannii sensu lato and sensu stricto Diseases of the small intestine Histotripsy of the prostate: dose effects in a chronic canine model Flea control failure?
cord-293151-g3758oeswhich chemotherapy protocol and why?
cord-275171-uokqn2u8Current situation of wildlife consumption in the market''Should wild animal consumption be allowed?''''
cord-275171-uokqn2u8How do the Chinese regard the relationship between wild animals and human beings?
cord-275171-uokqn2u8What drove respondents to start wild animal consumption?
cord-275171-uokqn2u8What kind of wild animals can be used for consumption?''
cord-341434-2xrdv92mIs there a difference between hare syphilis and rabbit syphilis?
cord-341434-2xrdv92mThe rabbit: a diurnal or nocturnal animal?
cord-341434-2xrdv92mWhat is your diagnosis?
cord-281819-2roflnanA smartphone- based portable diagnostic reader for the rapid detection of progesterone in milk Vocal contagion of emotions in non- human animals Does farm animals experience emotions and feelings?
cord-281819-2roflnanLiterature review and conclusions for future research Is continuous heart rate monitoring of livestock a dream or is it realistic?
cord-281819-2roflnanPositive and negative emotions in dairy cows: Can ear postures be used as a measure?
cord-281819-2roflnanThe use of infrared thermography for detecting digital dermatitis in dairy cattle: What is the best measure of temperature and foot location to use?
cord-319933-yp9ofhi8* Viral shedding patterns of coronavirus in patients with probable severe acute respiratory syndrome SARS vaccines: where are we?
cord-319933-yp9ofhi8An unusual hantavirus outbreak in southern Argentina: person- to- person transmission?
cord-319933-yp9ofhi8Efficacy assessment of a cell- mediated immunity HIV-1 vaccine( the step study): a double- blind, randomised, placebo- controlled, test- of- concept trial Human papillomavirus in cervical cancer Human papillomavirus research: do we still need animal models?
cord-319933-yp9ofhi8Phenotypic changes in Langerhans'cells after infection with arboviruses: a role in the immune response to epidermally acquired viral infection?
cord-263667-5g51n27eAfter a few inquiries about my wife's health, Dr. Mountin came to the point:''What are you veterinarians going to do for the public health now that the war is over?''
cord-263667-5g51n27eAre wild birds the true reservoir?
cord-263667-5g51n27eCould this be another form of distemper?
cord-263667-5g51n27eIs it possible the prion of the diseased brain can be secreted through nerve fibers that innervate the salivary gland?
cord-263667-5g51n27eShould I get an MD?
cord-263667-5g51n27eWhat are the 21st century challenges?
cord-264408-vk4lt83x( l- sIGN) is a receptor for severe acute respiratory syndrome coronavirus Glycomic characterization of respiratory tract tissues of ferrets: implications for its use in influenza virus infection studies Comparative analysis of monkeypox virus infection of cynomolgus macaques by the intravenous or intrabronchial inoculation route Phenotypic changes in langerhans'cells after infection with arboviruses: a role in the immune response to epidermally acquired viral infection?
cord-264408-vk4lt83xA novel model of lethal Hendra virus infection in African green monkeys and the effectiveness of ribavirin treatment Clinical outcome of henipavirus infection in hamsters is determined by the route and dose of infection recent progress in henipavirus research: molecular biology, genetic diversity, animal models Mucosal arenavirus infection of primates can protect them from lethal hemorrhagic fever sArs vaccines: where are we?
cord-264408-vk4lt83xA simple technique for infection of mosquitoes with viruses; transmission of Zika virus Human papillomavirus research: do we still need animal models?
cord-264408-vk4lt83xAn unusual hantavirus outbreak in southern Argentina: person- to- person transmission?
cord-264408-vk4lt83xemerg sArs: what have we learned?
cord-018151-5su98uanToward an Anthropology of Viral Hemorrhagic Fevers'Human Extinction and the Pandemic Imaginary Seeing Cellular Debris, Remembering a Soviet Method'Blaming the Rat?
cord-018151-5su98uanUnderstanding Multiple and Contradictory Human- Rat Relations as Situated Practices Blaming the Rat?
cord-018151-5su98uanWhat Is an Epidemic?
cord-018151-5su98uanWhat if infected rats moved from the rural hotspots of the epidemic into urban areas, transforming them into the equivalents of plague- ravaged Bombay on English soil?
cord-018151-5su98uann't We Got Right to the Tree of Life?','constrast[ed] with images of women afraid of rats; the woman's grip on the rat suggests determination, courage and fury'.
cord-018151-5su98uanthe Balance Blaming the Rat?
cord-287839-cslrz4yp, Hamburg ex Morocco Is it just another worble?
cord-287839-cslrz4ypShould a valid international health certificate be required?
cord-287839-cslrz4ypShould imported animals have a unique identifier( microchip, tattoo)?
cord-287839-cslrz4ypShould the importation of dogs, cats and ferrets be restricted to ports staffed by CDC quarantine personnel?
cord-287839-cslrz4ypStakeholders were asked questions such as Should the CDC establish a minimum age for importation of dogs, cats and ferrets?
cord-287839-cslrz4ypWho's Guarding the Gate?
cord-256615-gvq8uyfkHow can we be better prepared to identify emerging pathogens early?
cord-256615-gvq8uyfkHow many pathogenic viruses remain to be discovered?
cord-256615-gvq8uyfkIs it feasible to predict which animal viruses have the potential to cause disease in humans?
cord-256615-gvq8uyfkThe global distribution and burden of dengue Airborne transmission of influenza A/ H5N1 virus between ferrets Role of receptor binding specificity in influenza A virus transmission and pathogenesis Venezuelan equine encephalitis emergence: enhanced vector infection from a single amino acid substitution in the envelope glycoprotein Chikungunya virus adapts to tiger mosquito via evolutionary convergence: a sign of things to come?
cord-256615-gvq8uyfkThe human virome: new tools and concepts Human polyomaviruses in disease and cancer Bats and their virome: an important source of emerging viruses capable of infecting humans Overviews of pathogen emergence: which pathogens emerge, when and why?
cord-256615-gvq8uyfkWhat is the best strategy for identifying and limiting the menace from novel, zoonotic viruses?
cord-280427-smqc23vrAre other species such as mosquitoes, houseflies responsible for the transmission of virus to humans?
cord-280427-smqc23vrAre there any precautions to be taken with live animals or animal products?
cord-280427-smqc23vrCan companion animals become infected with Covid-19?
cord-280427-smqc23vrCan your pet get COVID-19?
cord-280427-smqc23vrHow to protect pets if you are sick?
cord-280427-smqc23vrThe role of environmental factors to transmission of SARS- CoV-2( COVID-19) Is COVID-19 the first pandemic that evolves into a panzootic?
cord-267188-1ldynibmHow do national policies regarding universal primary education and their implementation at the local level affect community and family expectations, their socialization of children and different family members'relation with domestic and wild animals?
cord-267188-1ldynibmOne exercise uses probes focused around senses( e.g., What about animals you smelled?
cord-267188-1ldynibmOr animals you heard?) to improve recall.
cord-267188-1ldynibmSome of the questions to be explored might include: how does urbanization and exposure to"international"norms affect attitudes and patterns of consumption of different types of wildlife meat?
cord-267188-1ldynibmThus"rice field rat"is not a response obtained when"What do you hunt?"is asked.
cord-267188-1ldynibmWhat effects do various approaches to communitybased natural resource management in different types of communities have on the frequency and type of interaction with domestic and wild animals?
cord-267188-1ldynibmWhat links bats to emerging infectious diseases?
cord-318407-uy0f7f2oHow must academic veterinary medicine adapt to prepare veterinarians to respond to these new needs?
cord-318407-uy0f7f2oHow will these changes alter the needs of society?
cord-318407-uy0f7f2oMisleading media reporting?
cord-318407-uy0f7f2oThe general epidemiologist: is there a place in today's epidemiology?
cord-318407-uy0f7f2oor do we?
cord-347872-naz24vctInstitute of Medicine Host phylogeny constrains cross- species emergence and establishment of rabies virus in bats Ecotourism and conservation: two cases from Brazil and Peru Status and trends of amphibian declines and extinctions worldwide Are ducks contributing to the endemicity of highly pathogenic H5N1 influenza virus in Asia?
cord-347872-naz24vctIs community- based ecotourism a good use of biodiversity conservation funds?
cord-347872-naz24vctLoss of fish populations from unexploited remote lakes in Ontario, Canada as a consequence of atmospheric fallout of acid Produce handling and processing practices Bat white- nose syndrome: an emerging fungal pathogen?
cord-347872-naz24vctPerfluorinated chemicals infiltrate ocean waters: link between exposure levels and stable isotope ratios in marine mammals Increasing the value of wildlife through non- consumptive use?
cord-347872-naz24vctSummary of avian influenza activity in Europe Population- dynamics of fox rabies in Europe Sustainable control of zoonotic pathogens in wildlife: how to be fair to wild animals?
cord-347872-naz24vctUsing mathematical models in a unified approach to predicting the next emerging infectious disease Economic importance of bats in agriculture Could localized warm areas inside cold caves reduce mortality of hibernating bats affected by white- nose syndrome?
cord-294956-9o3utlfx: A response to the legal challenge Great Ormond Street Hospital for Children NHS Foundation Trust EWCA Civ 410 Children's NHS Foundation Trust and Evans Supreme Court Animal Welfare: A cool Eye towards Eden A history of animal welfare science Death is a welfare issue How should death be taken into account in welfare assessments?
cord-294956-9o3utlfxA cross- sectional observational study How happy is your pet?
cord-294956-9o3utlfxHow can we decide what is right and what is wrong in the treatment of farm animals?
cord-294956-9o3utlfxMy Family and Other Animals: Pets as Kin The Best Interests of the Child: A Gateway to Children's Rights?
cord-294956-9o3utlfxNot all dogs are equal: Perception of canine welfare varies with context Mapping discussion of canine obesity between veterinary surgeons and dog owners: A provisional study Do dog owners perceive the clinical signs related to conformational inherited disorders as'normal'for the breed?
cord-294956-9o3utlfxTaking seriously the best interests of the animal Deciding together?
cord-294956-9o3utlfxThe use and abuse of Aesculapian authority in veterinary medicine Informed consent in veterinary medicine: Ethical implications for the profession and the animal Critical anthropomorphism, animal suffering, and the ecological perspective Post- human families?
cord-294956-9o3utlfxWhat do animals want?
cord-352832-uih7alibA comparison of bats and rodents as reservoirs of zoonotic viruses: are bats special?
cord-352832-uih7alibBats'fierce immune systems drive viruses to higher virulence, making them deadlier in humans Tip of the iceberg': is our destruction of nature responsible for Covid-19?
cord-352832-uih7alibIt is clear that human actions, such as the hunting of wild animals and mindless destruction of biodiversity, create the underlying favorable conditions for new viruses and diseases such as Covid-19, which threaten the existence of humanity itself, so how come humans still engage in destructive behaviors that threaten their own existence?
cord-352832-uih7alibThe Guardian Bats as a continuing source of emerging infections in humans Rolling updates on coronavirus disease( COVID-19) Bats and viruses: friend or foe?
cord-352832-uih7alibThe emerging role of Buddhism in clinical psychology: toward effective integration Coronavirus outbreak raises question: why are bat viruses so deadly?
cord-028275-szb45jm2Describe the significance of animal modeling in biotechnology?
cord-028275-szb45jm2Discuss about different types of animal model to study the pathogenesis of rheumatoid arthritis?
cord-028275-szb45jm2Explain the various methods for evaluation of experimental models of Multiple sclerosis?
cord-028275-szb45jm2Give an example which shows the impact of the epigenetics in the initiation of RA?
cord-028275-szb45jm2How CIA is induced and how the ability of medications is evaluated in mice?
cord-028275-szb45jm2The relevance of animal models in multiple sclerosis research Current and emerging treatment of multiple sclerosis HLA and rheumatoid arthritis: how do they connect?
cord-028275-szb45jm2What is the reason of reportedly experiencing different animal models for studying the pathogenesis of Rheumatoid arthritis?
cord-028275-szb45jm2Which types of evaluation should be performed after"collagen- induced arthritis"aroused?
cord-028275-szb45jm2Why the presence of inflammation in the CNS is considered as a hallmark of Multiple Sclerosis?
cord-031482-atltc10d: Is there a connection?
cord-031482-atltc10dAn incident in DeLand, Fla. in 2018, when a woman being held captive at gunpoint by her abusive boyfriend was able to alert veterinary staff who in turn called the police( Robbins, 2018), brought to national attention what was just beginning to be discussed in professional journals: how should veterinarians and their staffs, the majority of whom now are women( Kelly, 2017), respond to suspected domestic violence in their clientele?
cord-031482-atltc10dAre there animals at home?
cord-031482-atltc10dAre you worried about their welfare?
cord-031482-atltc10dHow are they cared for?
cord-031482-atltc10dSocial Work in Health Care Arrest and prosecution of animal sex abuse( bestiality) offenders in the United States Cute and cuddly and a whole lot more?
cord-031482-atltc10dThe Link between interpersonal violence and animal abuse A study on the relationship of child abuse and pet abuse Animal cruelty and bullying: Behavioral markers of delinquency risk or causal antecedents of delinquent behavior?
cord-031482-atltc10dThe pet connection: Pets as a conduit for social capital?
cord-031482-atltc10dThey burn brightly, but only for a short time": The role of social workers in companion animal grief and loss Is counseling going to the dogs?
cord-031482-atltc10dWhen domestic violence arrives at the clinic door: How veterinary staff can respond to abused clients and patients The community context of animal and human maltreatment: Is there a relationship between animal maltreatment and human maltreatment: Does neighborhood context matter?
cord-009594-0rfbmi0qVery soon after arrival, Joe arrived on my doorstep, announced who he was, checked who I was and asked why the[ expletive] was I sitting up reading a book when there was vet work to be done?
cord-009594-0rfbmi0qCan we better articulate a more robust and satisfying basis for the AVA's policy and advocacy work on animal welfare issues?
cord-009594-0rfbmi0qCan you join the leadership crew and help to steer the profession?
cord-009594-0rfbmi0qHow do we reflect your views and represent you to stakeholders and politicians?
cord-009594-0rfbmi0qIs there a common thread or philosophy on animal welfare across all members?
cord-009594-0rfbmi0qNot involved with cows, horses, small animals or practice management?
cord-009594-0rfbmi0qPerhaps all of these?
cord-009594-0rfbmi0qShould AVA hold a conversation- type event?
cord-009594-0rfbmi0qShould we have a stand- alone strategy?
cord-009594-0rfbmi0qShould we have a welfare committee?
cord-009594-0rfbmi0qWhat are the most important ones for our members and the long- term benefits for animals?
cord-009594-0rfbmi0qWhere to on welfare?
cord-329206-xsxkn5myA review Human- cat interactions: Relationships with, and breed differences between, non- pedigree, Persian and Siamese cats Factors influencing the temporal patterns of dyadic behaviours and interactions between domestic cats and their owners Are cats( Felis catus) from multi- cat households more stressed?
cord-329206-xsxkn5myA simple, reliable tool for owners to assess the body condition of their dog or cat Usefulness of muscle condition score and ultrasonographic measurements for assessment of muscle mass in cats with cachexia and sarcopenia How often do veterinarians assess the bodyweight and body condition of dogs?
cord-329206-xsxkn5myAnimal well- being I. General considerations Indicators of poor welfare Family quality of life: Moving from measurement to application Is quality of life a useful concept for companion animals?
cord-329206-xsxkn5myCan human contact reduce stress for shelter dogs?
cord-329206-xsxkn5myCan we really measure animal quality of life?
cord-329206-xsxkn5myExploration of the hypothalamic- pituitary- adrenal function as a tool to evaluate animal welfare Why is there no simple way of measuring animal welfare?
cord-329206-xsxkn5myIn The Welfare of Cats Stress, security, and scent: The influence of chemical signals on the social lives of domestic cats and implications for applied settings A case- controlled comparison of behavioural arousal levels in urine spraying and latrining cats Vertical or horizontal?
cord-329206-xsxkn5myIs there a relationship between attitudes of shelter staff to cats and the cats'approach behaviour?
cord-329206-xsxkn5myMethodologies for measuring quality of life in people and other animals Development of a discriminative questionnaire to assess nonphysical aspects of quality of life of dogs Enhancing quality of life for dogs and cats in confined situations Stress and adaptation of cats( Felis silvestris catus) housed singly, in pairs and in groups in boarding catteries Animal- based measures for the assessment of welfare state of dairy cattle, pigs and laying hens: Consensus of expert opinion Too cute to kill?
cord-329206-xsxkn5myThe effect of hiding enrichment on stress levels and behaviour of domestic cats( Felis sylvestris catus) in a shelter setting and the implications for adoption potential Will a hiding box provide stress reduction for shelter cats?
cord-329206-xsxkn5mythe study of facial expressions in non- human animals, using the domestic cat as an exemplar Development and application of CatFACS: Are human cat adopters influenced by cat facial expressions?
cord-302222-9ad0fw6zAn interesting question is: who will pay for vaccination of feedlot cattle?
cord-302222-9ad0fw6zIs the economic benefit there for the meat industry, and will vaccination reduce the cost of other preventive measures and testing or will vaccine costs simply be on top of other costs?
cord-302222-9ad0fw6zOne health: the importance of companion animal vector- borne diseases Arthropod- borne infectious diseases of the dog and cat Zoonoses Control in dogs How to eradicate canine rabies: a perspective of historical efforts Mass vaccination campaign against rabies: are dogs correctly protected?
cord-302222-9ad0fw6zSince ground beef only contributes about one- third of human infections, how could vaccines be used as a means of reducing other sources of food contamination?
cord-302222-9ad0fw6zThe use of veterinary vaccines for prevention and control of Rift Valley fever: memorandum from a WHO/ FAO meeting ZH501-VSVRI: Is it still the best choice for vaccination against Rift Valley fever in Egypt?
cord-302222-9ad0fw6zWill government agencies concerned with human health subsidize the cost, without empirical demonstration of a human health benefit?
cord-302222-9ad0fw6zunderstanding the dual- host lifestyle of Lyme disease spirochaetes The emergence of Lyme disease Vaccines against Lyme disease: what happened and what lessons can we learn?
cord-302222-9ad0fw6zwhat happens on the ground?
cord-299315-s43gw24kBut what are the objects, goods, or benefits(and harms) that enable states of heath?
cord-299315-s43gw24kCatastrophic ape decline in western equatorial Africa Potential for Ebola transmission between gorilla and chimpanzee social groups Vaccinating captive chimpanzees to save wild chimpanzees Should protections for research with humans who can not consent apply to research with nonhuman primates?
cord-299315-s43gw24kFirst, a significant question is'why now?'
cord-299315-s43gw24kHow AIDS emerged from an African forest Toward proof of concept of a One Health approach to disease prediction and control From''Us vs. Them''to''Shared Risk'': Can animals help link environmental factors to human health?
cord-299315-s43gw24kNeglected tropical diseases?
cord-299315-s43gw24kSpeculations and directions for future research Emerging infections: Condemned to repeat?
cord-299315-s43gw24kThe Lancet Can a chimp say''No''?
cord-299315-s43gw24kThe duration of the effects of repeated widespread badger culling on cattle tuberculosis following the cessation of culling Has culling been properly assessed as a valid and justified control intervention measure for zoonotic diseases?
cord-299315-s43gw24kWhy are clinicians still empty- handed, with no vaccines and no cure?
cord-299315-s43gw24kWhy only now has the Ebola virus, which has previously emerged in isolated regions, become a regional endemic( Olival and Hayman 2014; Olson et al. 2012)?
cord-022506-fkddo12nCan appropriate care realistically be delivered?
cord-022506-fkddo12nCan the facility afford the cost and time for care?
cord-022506-fkddo12nHow will it impact resources available for other cats?
cord-022506-fkddo12nIf the cat is not adopted, do humane long- term care options exist in the shelter?
cord-022506-fkddo12nIn the case of animal shelters, additional considerations should include Will the cat be adoptable?
cord-022506-fkddo12nScaredy cat or feral cat?
cord-022506-fkddo12nWhat is the cause of its illness, and how can I prevent this from affecting others?"
cord-022506-fkddo12nWhat steps can be taken to minimize the holding time required for treatment?
cord-022506-fkddo12nWhat welfare assessment will be used to measure quality of life in the shelter?
cord-022506-fkddo12nWhen determining if cats with special needs can be humanely cared for in a population setting, the following goals and considerations should be addressed: What measures must be implemented to prevent transmission of disease to other cats or people?
cord-022506-fkddo12nWhen individuals are ill, their health and well- being is always a priority; however, it should also immediately trigger the clinician to ask,"Why is this individual sick?
cord-022506-fkddo12nWill the care provided result in a cure or adequate management of the disease or problem behavior?
cord-258389-1u05w7r4Are cells obtained directly from organs and tissues in primary cell culture?
cord-258389-1u05w7r4Do stem cells can not differentiate into other kinds of cells?
cord-258389-1u05w7r4Does passage effect leads to an increase in the virulence of cultured viruses?
cord-258389-1u05w7r4Drugs must be tested, manufactured?
cord-258389-1u05w7r4Is Bevacizumab approved for the treatment of colorectal cancer?
cord-258389-1u05w7r4Is IFN- α used for the treatment of multiple sclerosis?
cord-258389-1u05w7r4Is identity testing a way to determine purity of culture?
cord-258389-1u05w7r4Is secondary culture used for studying transformed cells?
cord-258389-1u05w7r4Is the VLP- based HPV vaccine approved by the FDA?
cord-258389-1u05w7r4Living cells are used in organ- on- a- chip microfluidic cell culture Can embryonic cells be cultured without any feeder layer?
cord-258389-1u05w7r4Serum is one of the basic components of cell culture media( true/ false)?
cord-258389-1u05w7r4What are the different phases of the growth curve?
cord-258389-1u05w7r4What is the Hayflick effect?
cord-258389-1u05w7r4What is the source of cells for primary monolayer cell culture?
cord-258389-1u05w7r4What was the first recombinant human protein?
cord-294312-ju6vuywmAre there places in the world where one might travel without worrying about rabies?
cord-294312-ju6vuywmAre there special government laboratories that conduct specialized rabies testing?
cord-294312-ju6vuywmAtypical rabies encephalitis in a six- year old boy: clinical, radiological, and laboratory findings Rabies: still a uniformly fatal disease?
cord-294312-ju6vuywmCan I get rabies if I handle blood, feces, or urine?
cord-294312-ju6vuywmCan international public health teams actually halt and remove a moving viral epizootic outbreak in a geographical area?
cord-294312-ju6vuywmCan scientists actually determine the origin of a rabies virus variant by way of genetic testing and methodologies?
cord-294312-ju6vuywmDo coldblooded animals, insects, or birds have a risk for acquiring this deadly disease?
cord-294312-ju6vuywmIs there a relationship between rabies and zombies?
cord-294312-ju6vuywmIs there a way to vaccinate wildlife using a recombinant vaccine dropped from aircraft?
cord-294312-ju6vuywmThe first question that comes to mind is"where did the United Kingdom homeopathic pharmacy obtain rabid dog saliva?"
cord-294312-ju6vuywmWhere exactly do most cases of rabies occur in the world?
cord-294312-ju6vuywmWhich type of animals are often more"at risk"for contracting rabies virus, otherwise known as highrisk animals?
cord-278195-1sle0d1jChildren and adults rapidly detect snakes based on their simple features Last Child in the Woods: Saving our Children from Nature- Deficit Disorder Who Cares About Wildlife?
cord-278195-1sle0d1jFor How many species of mammals are there?
cord-278195-1sle0d1jRather Conspicuous than Endangered?
cord-278195-1sle0d1jRenovables Knowledge and perceptions of Macedonian hunters and herders: the influence of species- specific ecology of bears, wolves, and lynx Human preferences for colorful birds: vivid color or pattern?
cord-278195-1sle0d1jScary and nasty beasts: self- reported fear and disgust of common phobic animals Which emotions are basic?
cord-278195-1sle0d1jThe live bird trade in Brazil and its conservation implications: an overview Toward a psychology of human- animal relations Overcoming Animal and Insect Phobias: How to Conquer Fear of Dogs, Snakes, Rodents, Bees, Spiders and More Consensus on criteria for potential areas for wolf reintroduction in Mexico Prevalence and factors associated with phobias among women Schoolchildren and one of the most unpopular animals: Are they ready to protect snakes?
cord-278195-1sle0d1jWhat makes some species of milk snakes more attractive to humans than others?
cord-278195-1sle0d1jWhat's so especial about slithering serpents?
cord-278195-1sle0d1jWhat's social about social emotions?
cord-278195-1sle0d1ja comparasion of pond owners and non- owners Does colour matter?
cord-278195-1sle0d1jdoes beauty of animals increase the respondents willingness to protect them?
cord-278195-1sle0d1jwill it Take to Put the Action into the Amphibian Conservation Plan?
cord-279146-8d3dym7gDo wetland conditions in the Mississippi Delta hardwoods influence mallard recruitment?
cord-279146-8d3dym7gEffect of dietary fatty acid composition on depot fat and exercise performance in a migrating songbird, the red- eyed vireo Rapid changes in the size of different functional organ and muscle groups during refuelling in a long- distance migrant shorebird Fuel storage rates before northward flights in red knots worldwide: facing the severest ecological constraint in tropical intertidal environments?
cord-279146-8d3dym7gExtreme endurance flights by landbirds crossing the Pacific Ocean: ecological corridor rather than barrier?
cord-279146-8d3dym7gHow and why do insects migrate?
cord-279146-8d3dym7gHow fast can birds migrate?
cord-279146-8d3dym7gIntegrating meteorological conditions into migration research Stochastic atmospheric assistance and the use of emergency staging sites by migrants American white pelican soaring flight times and altitudes relative to changes in thermal depth and intensity Measurements of thermal updraft intensity over complex terrain using American white pelicans and a simple boundary- layer forecast model Impacts of a global climate cycle on the population dynamics of a migratory songbird Arrival timing and seasonal reproductive performance in a long- distance migratory landbird Wind drift compensation, flyways, and conservation of diurnal, migrant neotropical lepidoptera Migration of the painted lady butterfly, Vanessa cardui, to north- eastern Spain is aided by African wind currents Weather in the breeding area and during migration affects the demography of a small long- distance passerine migrant How hazardous is the Sahara Desert crossing for migratory birds?
cord-279146-8d3dym7gIs animal migration disappearing?
cord-279146-8d3dym7gMorphological response of songbirds to 100 years of landscape change in North America Spring migration of the Siberian knots Calidris canutus canutus: results of a co- operative Wader Study Group project Red knots give up flight capacity and defend food processing capacity during winter starvation Intraspecific variation in avian pectoral muscle mass: constraints on maintaining manoeuvrability with increasing body mass Migration: the biology of life on the move What is migration?
cord-279146-8d3dym7gNorthward migration of Afro- Siberian knots Calidris canutus canutus: high variability in red knots numbers visiting stopover sites on French Atlantic coast Bats are natural reservoirs of SARS- like coronaviruses Birds: blowin'by the wind?
cord-279146-8d3dym7gOptimal departure decisions of songbirds from an experimental stopover site and the significance of weather Are female monarch butterflies declining in eastern North America?
cord-279146-8d3dym7gPolarized light cues underlie compass calibration in migratory songbirds Magnetic compass of migratory savannah sparrows is calibrated by skylight polarization at sunrise and sunset Whitethroated sparrows calibrate their magnetic compass by polarized light cues during both autumn and spring migration Nocturnal life of young songbirds well before migration Long- distance biological transport processes through the air: Can nature's complexity be unfolded in- silico?
cord-279146-8d3dym7gThe effect of wind, season and latitude on the migration speed of white storks Ciconia ciconia, along the eastern migration route Is there a connection between weather at departure sites, onset of migration and timing of soaring- bird autumn migration in Israel?
cord-279146-8d3dym7gThe migration ecology of birds Effects of horseshoe crab harvest in Delaware Bay on red knots: are harvest restrictions working?
cord-279146-8d3dym7gWest Nile virus, Lyme disease, influenza A and enteropathogens Thermal windows on Brazilian free- tailed bats facilitate thermoregulation during prolonged flight Non- breeding season events influence sexual selection in a long- distance migratory bird Does a'turbophoretic'effect account for layer concentrations of insects migrating in the stable night- time atmosphere?
cord-318061-xe8lljz0: How Can Companion Animals Help in Connection with Coronary Heart Disease, Obesity, Diabetes and Depression?
cord-318061-xe8lljz0: Is there risk with breed ownership?
cord-318061-xe8lljz0: What are the risks?
cord-318061-xe8lljz0A One Health perspective European dog owner perceptions of obesity and factors associated with human and canine obesity The impact of pets on human health and psychological well- being fact, fiction, or hypothesis?
cord-318061-xe8lljz0A review with consideration of comparative aspects Neurophysiological correlates of affiliative behaviour between humans and dogs Human interaction and cortisol: Can human contact reduce stress for shelter dogs?
cord-318061-xe8lljz0An epidemiologic study Celebrating International Mud Day Dogs and transmission of infection to man, respected member of the family?
cord-318061-xe8lljz0Being licked by a dog can be fatal: Capnocytophaga canimorsus sepsis with purpura fulminans in an immunocompetent man How many people have been bitten by dogs?
cord-318061-xe8lljz0Do the stereotypies of pigs, chickens and mink reflect adaptive species differences in the control of foraging?
cord-318061-xe8lljz0Dominance in domestic dogs revisited: Useful habit and useful construct?
cord-318061-xe8lljz0How much of the potential pathogen is needed to become a health risk?
cord-318061-xe8lljz0How serious is the disease, what is the chance of complications, and what economic consequences may be expected( e.g., labor hours lost)?
cord-318061-xe8lljz0Intern Overweight in adult cats: A cross- sectional study Raw diets for dogs and cats: A review, with particular reference to microbiological hazards Evaluation of raw food diets for dogs Alternative& raw food diets: What do we know?
cord-318061-xe8lljz0Is that a problem?
cord-318061-xe8lljz0NDM-5 ST167 and CTX- M-9 ST69 Escherichia coli between dogs and humans in a family Zooanthroponotic transmission of drug- resistant Pseudomonas aeruginosa Is your dog empathic?
cord-318061-xe8lljz0New allergies but the same allergens Does pet ownership in infancy lead to asthma or allergy at school age?
cord-318061-xe8lljz0Stress and adaptation in cats( Felis sylvestris catus) housed singly, in pairs and in groups in boarding catteries Effects of density and cage size on stress in domestic cats( Felis sylvestris catus) housed in animal shelters and boarding catteries Stereotypies in carnivores: Does pacing stem from hunting, ranging or frustrated escape?
cord-318061-xe8lljz0Who is exposed to the potential hazard and for how long or how often?
cord-021158-075vh5jg( …) We had developed well in 84- 85, so how could we consolidate our system, how could we really sell it, how could we duplicate it?
cord-021158-075vh5jg, Thèse pour le doctorat vétérinaire Challenges facing the farm animal veterinary profession in England: a qualitative study of veterinarians'perceptions and responses Annoying owners: routine interactions with problematic clients in a general veterinary practice Broken biosecurity?
cord-021158-075vh5jgAnd I thought"but this is not the feed from the co- op?".
cord-021158-075vh5jgAnd in this example, what happened in the end?
cord-021158-075vh5jgBritain Is prevention better than cure?
cord-021158-075vh5jgBut are n't you stealing work from the technicians?
cord-021158-075vh5jgBut what about the economic model on which this kind of expertise is based and how it is actually related to the use of antimicrobials?
cord-021158-075vh5jgCould we look beyond the symbols and images of professional and political discourses and see whether these preventive approaches that might change the way veterinary medicine is practiced, and how antibiotics are used, rely on actual knowledge and practices and, if so, where and since when?
cord-021158-075vh5jgI even went to Cuba for X. Trying to sell products?
cord-021158-075vh5jgOr might you impose sanctions at some point?
cord-021158-075vh5jgSo at vet school, you did n't think about working with dogs?
cord-021158-075vh5jgSo the mother was a carrier, so we thought:"what if we use an antiseptic powder?"
cord-021158-075vh5jgWhat does he want?
cord-021158-075vh5jgWhat is the place of animals in the social sciences?
cord-021158-075vh5jgWho were you doing this with?
cord-021158-075vh5jgWhy do veterinarians ask for antimicrobial susceptibility testing?
cord-021158-075vh5jgYet were the farmers prepared to pay for their visits, as they would have done with rural vets at the time?
cord-021158-075vh5jgYou have suppliers for these products or you manufacture them yourselves?
cord-021158-075vh5jgYou just let him know, asked him to be careful, and let it go?
cord-021158-075vh5jgcord-021158- 075vh5jg authors: Fortané, Nicolas title: Antimicrobial resistance: preventive approaches to the rescue?
cord-021158-075vh5jgoder berufener Schützer des Tieres?
cord-257597-jy4a8al8: What's the problem, who is responsible, and what can be done?
cord-257597-jy4a8al8Can we expect to see a diversification in the sorts of animals commoditised, the destinations offered and array of interactions with animals available?
cord-257597-jy4a8al8Could this technology be used to contribute to animal welfare goals in animal- based tourism or would it perhaps make it worse?
cord-257597-jy4a8al8From a compassionate perspective, are there any activities where the use of animals can never be accepted?
cord-257597-jy4a8al8Given the ostensible incompatibility of these two points of departure, which one ought we to prioritise when there is a conflict?
cord-257597-jy4a8al8If animals are involved, how many animals need to be involved in a given activity?
cord-257597-jy4a8al8In animal- based tourism, which level of being should be ascribed moral priority?
cord-257597-jy4a8al8In light of such profound challenges to animal lives and welfare, what is the future of animal- based tourism?
cord-257597-jy4a8al8Interesting?
cord-257597-jy4a8al8Is the interest for the tourism( and thus society) bigger than the cost of the individual animal?
cord-257597-jy4a8al8Not such smart tourism?
cord-257597-jy4a8al8Parallel to this and as a result of a few notable scandals( such as Cecil the Lion, Blackfish, and exposures of Phajaan, breaking of the will of elephants to get them docile in Thailand), can we also expect increased scrutiny of the industry in terms of its treatment of animal workers?
cord-257597-jy4a8al8Society s view of animals'roles in animal- based tourism- How do the perceptions, values and attitudes of tourists correspond to those of tourism operators and animal welfare organizations?
cord-257597-jy4a8al8The Coronavirus Threat to Wildlife Tourism and Conservation Agri- Tourism: In between Rural Change, Tourism Restructuring and Environmental Imperatives A New Urban Dispositif?
cord-257597-jy4a8al8The Heart of the Movement?
cord-257597-jy4a8al8The initial question is: Is there a need to use animals at all?
cord-257597-jy4a8al8What Do We Know About Wild Boar in Iberia?
cord-257597-jy4a8al8What will be the long- term impact of the so- called flight shame movement on animal- based tourism abroad?
cord-257597-jy4a8al8and, e.g., corporate social responsibility to push through improved standards of animal welfare in tourism?
cord-022708-rr3xua38A new focus in congestive heart failure?
cord-022708-rr3xua38Did it change much for your income?
cord-022708-rr3xua38Do people just find themselves taking over the mantle of head vet/ business owner as a rite of passage?
cord-022708-rr3xua38Do you find your age and experience level makes it harder?
cord-022708-rr3xua38Given my'young grasshopper'status I found myself thinking, what does it take to be an entrepreneur in the veterinary industry?
cord-022708-rr3xua38How do you find being responsible for a team?
cord-022708-rr3xua38How does the AVA systematically review and assess policies for possible unintended consequences, implications, misrepresentation of the profession, or the possibility of setting a precedents that is not in the interest of the profession as whole?
cord-022708-rr3xua38How long did the arrangement last?
cord-022708-rr3xua38Is it a trial?
cord-022708-rr3xua38Is it part of a vocational placement related to a course of study?
cord-022708-rr3xua38Most importantly how could we assist our members in providing better care to ensure happier clients?
cord-022708-rr3xua38Other than student placements-are there any other situations where unpaid work is permissible?
cord-022708-rr3xua38Should the board review the live export policy, will the AVA stand by its recommendations to the Moss review 3 and ensure that relevant people with leadership skills, deep knowledge and understanding of the industry, animal health and welfare, and epidemiology are sought?
cord-022708-rr3xua38What motivated you to start your own business, Zach?
cord-022708-rr3xua38What was the nature of the work?
cord-022708-rr3xua38When the work is not part of a vocational placement, some of the major factors when considering whether work can be unpaid include; • Will the work be for the benefit of the individual, or the business?
cord-022708-rr3xua38an individual wanting to gain experience in the industry( no vocational placement)?
cord-022708-rr3xua38raise the question: is unpaid work permissible?
cord-022708-rr3xua38will power and effort?
cord-022708-rr3xua38… Is the dingo really just another type of dog?
cord-017112-5men6dfkUse of animals in research: a science- society controversy? cord-017112-5men6dfk ( 2) Would it be benefi cial for anyone? cord-017112-5men6dfk Alternatively, who would decide things should be or should not be? cord-017112-5men6dfk Are n't we imparting sufferings for the plants and animals by using these tools and technology on them? cord-017112-5men6dfk Autonomy: If one feels it is right, should things move on? cord-017112-5men6dfk Do those rights need protection? cord-017112-5men6dfk Each living being has evolved to grow in one condition, and if we put human gene or fi sh's gene in a plant or animal, what would be its effects? cord-017112-5men6dfk Fatal Cercopithecine herpesvirus 1( B virus) infection following a mucocutaneous exposure and interim recommendations for worker protection Studies on release and survival of biological substances used in recombinant DNA laboratory procedures Health care rights and responsibilities: a review of the European Charter of Patients'Rights Goodbye Dolly?
cord-017112-5men6dfkHowever, it is important that before we keep on proceeding, we should ask some basic questions to ourselves:( 1) Why am I doing this?
cord-017112-5men6dfkIs inflicting pain in any form, which may be by creating a disease model or studying mutations in animals, ethical or not?
cord-017112-5men6dfkOne big question is"Are we authorized to use animals the way we want?"
cord-017112-5men6dfkOr else someone feels it is wrong, should things stop?
cord-017112-5men6dfkRights and responsibilities: Are we exploiting somebody else's rights?
cord-017112-5men6dfkThe changes which unnatural gene transfer might be doing to the environment and the society?
cord-017112-5men6dfkThe ethics of human cloning After- birth abortion: why should the baby live What exactly is an exact copy?
cord-017112-5men6dfkVirtue ethics: Is this the best thing to do?
cord-017112-5men6dfkWhat about evolution?
cord-017112-5men6dfkWhat are their risks to other animals like birds, insects, and other higher animals( like monarch butterfl y and Bt crops)?
cord-017112-5men6dfkWhat if GM crops breed with other crops, would the biodiversity be lost?
cord-017112-5men6dfkWhat is good about it?
cord-017112-5men6dfkWhat would be effect of this experiment?
cord-017112-5men6dfkWhat would be harms associated with this work?
cord-017112-5men6dfkWhat would happen if the gene can fi nd an escape route to introduce itself in other members of that species or other species?
cord-017112-5men6dfkWhat would happen if the herbicide resistance gene could transfer itself in weeds, generating superweeds?
cord-017112-5men6dfkWho is going to be benefi ted?
cord-017112-5men6dfkWho would protect these?
cord-017112-5men6dfkWould the monogenetic crops, if not able to react appropriately to environmental stress, again face a situation like"Ireland's potato famine"?
cord-017112-5men6dfkwhy?
cord-274052-rjud75izAre we vaccinating too much?
cord-274052-rjud75izDid I ask too much from the client?
cord-274052-rjud75izDid I choose the right place, time, situation, climate?
cord-274052-rjud75izDid I feel pressed for time?
cord-274052-rjud75izDid I ignore( or even induce) worries in the client?
cord-274052-rjud75izDid I practice active listening?
cord-274052-rjud75izDid I properly structure the interview( introduction, aim, course, conclusion)?
cord-274052-rjud75izDid I respect the listener's need for pauses?
cord-274052-rjud75izDid I show empathy?
cord-274052-rjud75izDid I stimulate the client to ask questions?
cord-274052-rjud75izDid I take in all messages?
cord-274052-rjud75izDid I use diversion strategies( stray, digress, evade, deviate, disparage, patronize, condescend)?
cord-274052-rjud75izDid I use killer phrases?
cord-274052-rjud75izDid I use the correct query technique?
cord-274052-rjud75izIn veterinary medicine, overvaccination rather refers to vaccinating with excessive frequency, which has been controversial for more that a decade(''Are we vaccinating too much?''
cord-274052-rjud75izThe proposal is to assess the result of vaccination by asking the question: did the vaccinee's immune system recognise the antigen?
cord-274052-rjud75izWas my client's reality the same as mine?
cord-274052-rjud75izWhat do you suggest as an answer?
cord-274052-rjud75izWhen lecturing about pet vaccination and vaccine use in the last decade, I used to confront veterinary audiences with the following scenario:'A pediatrician client presents her cat to a vet and asks:''Doctor, why do I need to pay you a yearly visit for revaccination of my cat?
cord-274052-rjud75izWhy an interview?
cord-274052-rjud75izWhy has veterinary medicine adopted a practice that causes raised eyebrows in the biomedical environment, e.g. when talking to immunologists?
cord-274052-rjud75izWhy yearly?
cord-018332-893cckyzAre you going to cut down trees just because they are foreign trees?asks Bhonco indignantly( 216).
cord-018332-893cckyzJobs? cord-018332-893cckyz Why does n't he stand up like a man and take the rap?"
cord-018332-893cckyz[ D]o we extend'unconditional hospitality'to anthrax and ebola virus, to SARS?
cord-018332-893cckyzAfter Camagu argues that the village will be paid for this, and that the development will create jobs, she further challenges his thinking: What do villagers know about working in casinos? ….
cord-018332-893cckyzAnd what do they know about keeping those kinds of gardens?
cord-018332-893cckyzAs Talal Asad argues in"What Do Human Rights Do?
cord-018332-893cckyzAs he tells the protagonist of his manipulations, Nick queries:"So even in the capacity of puppet I was not indispensible?"
cord-018332-893cckyzAs in The Reluctant Passenger, the association of big business with the law is revealed as the developers'attempt to intimidate the villagers'opposition with claims of their connections to the government:"How will you stop us?
cord-018332-893cckyzBhonco's desire is reterritorialized, seeing as he has no problem with the development of the casino city, which would break these laws, a project which the developers reveal involves the killing of many of the village's trees:"How can we call it a grove when we're going to cut down all these trees to make way for the rides?"
cord-018332-893cckyzHe becomes a kind of nationalist manager when he threatens Camagu's membership of the community in response to Camagu's anti- development arguments:"Who are you to talk for the people of Qolorha? …
cord-018332-893cckyzHere van der Merwe explains her position after Nick queries:"Is n't breeding natural?"
cord-018332-893cckyzHow Christian is Christian enough?
cord-018332-893cckyzHow do we think outside of dominant thought and beyond its closures?
cord-018332-893cckyzHow human is human enough?
cord-018332-893cckyzHow many men?
cord-018332-893cckyzHow"proper,"to go back to Heidegger, is proper enough?
cord-018332-893cckyzIn contrast, Xoliswa, who adopts Western knowledge as universal, dismisses indigenous knowledge as nonsense:"What can we say about a man who believes in a snake?"
cord-018332-893cckyzMda seems to acknowledge that this approach of ecotourism is not exactly the most radical approach either, as his later novel, The Whale Caller What Do Human Rights Do?
cord-018332-893cckyzMorris attempts to finish Luc's sentence, offering"An ass?", to which Luc replies:"I was thinking of something more useless, like a … a eunuch"( 259).
cord-018332-893cckyzOr do you think that just because you run after daughters of Believers, that gives you the right to think you belong here?"
cord-018332-893cckyzSince when do you belong here?
cord-018332-893cckyzSo eventually, you know, how Aryan is Aryan enough?
cord-018332-893cckyzThe elders reply to Bhonco's argument by noting the difference of life under consideration here:"Shall we now be required to teach revered elders like Bhonco about our taboos?
cord-018332-893cckyzToward the novel's end, the community stops the casino development when Dalton gets a court order declaring Qolorha a"national heritage site"( 269), something Camagu had suggested earlier in response to the developers'"How will you stop us?"
cord-018332-893cckyzWhat Is Sex?
cord-018332-893cckyzWhat do women know about using machines that clean?
cord-015021-pol2qm74( 3) Should future clinical trials be based on new classifications of illness such as MODS, SIRS, APACHE III, SAP II, MRM, etc., or should trials be dedicated to specific diseases-urinary tract infections, pneumonia, trauma patients, cardiac surgery and other specific problems, rather than generalized problems of sepsis, the sepsis syndrome and other classifications?
cord-015021-pol2qm743-Is the ACCP classification of sepsis useful at the bedside to select oatients?
cord-015021-pol2qm74Abnormally high skeletal muscle pO 2 in septic patients and its normalization during recovery: Evidence against tissue hypoxia but for impaired oxygen metabolism of skeletal muscle?
cord-015021-pol2qm74Administration of exogenous IFN?
cord-015021-pol2qm74And, finally, how can the participants be sure that the trial will be stopped at the right time, to ensure that no treatment is given to any patient that might be harmful?
cord-015021-pol2qm74Are all eligible patients being studied, and their results reported?
cord-015021-pol2qm74Are all the participants truly unbiased about the relative merits of the regimens being studied?
cord-015021-pol2qm74Before using the model for risk of death in septic patients, is it mandatory to validate it( by calibration, i.e. goodness of fit, and discrin'dnation, i.e., ROC curves) first on a data base using the same definition for sepsis as in the trial and secondly on the placebo group of the trial?
cord-015021-pol2qm74Can it achives a significant improvement in the septic course, organ dysfunction, and final outcome?
cord-015021-pol2qm74Conversely, administration of anti- IFN?
cord-015021-pol2qm74Correlatively the RNI inhibitor MMLA induces in vitro a decrease in the rate of bacterial killing, fxom 78% to 57%, in macrophages triggered with IFN-?+ LPS.
cord-015021-pol2qm74How can organ dysfunction and/or failure be defined?
cord-015021-pol2qm74How should we decide which of them should be brought to clinical trial?
cord-015021-pol2qm74If there is agreement that thin is an appropriate antibiotic protocol, should it not be used in all seriously ill septic patients in the hospital?
cord-015021-pol2qm74In contrast, GF109203X significantly reduced ICAM-1 expression induced by Interferon- y( IFN-?)
cord-015021-pol2qm74In fact, the IFN-? and IL-1 induced adhesion of PBMC to cytokine treated HUVEC could be downregulated by the PKC- inhibitor, whereas TNFc~-and LPS- mediated adhesion was not influenced.
cord-015021-pol2qm74In other words, should we now begin to have clinical trials on specific diseases with causes that are known and can be attacked?
cord-015021-pol2qm74Interferon-?
cord-015021-pol2qm74Is like being compared with like-are all the end points and the standards for measuring them clearly defined so that they can not be misunderstood?
cord-015021-pol2qm74Is there any role for antioxidative therapy in sepsis?
cord-015021-pol2qm74Is truly informed consent being sought that will satisfy not only the patient's right to choose what happens to him, but also the law of the land?
cord-015021-pol2qm74MIF secretion also was induced by TNFoc( 1 ng/ ml) and IFN?
cord-015021-pol2qm74MIF secretion is induced by LPS, TNFc~ and IFN?.
cord-015021-pol2qm74Macrophages of C57BL/10ScCr mice are incapable of producing interferon-~( IFN~) which we could show to be obligatory for the production of IFN?
cord-015021-pol2qm74On closer investigation the impaired IFN?
cord-015021-pol2qm74The IFN?
cord-015021-pol2qm74The absence of sensitization to LPS in Lps d C57BL/10ScCr mice was identified as being due to their inability to produce interferon-7( IFN?).
cord-015021-pol2qm74The clinical"take"rate o? cultured epithelial autografts( CEA) has been observed to Increase with transplantation to allodermls, but the reasons for the improved clinical performance have not yet been defined.
cord-015021-pol2qm74The inability to produce adequate amounts of IL-2, most likely attributable to alterations in the transmission of signals from the cell membrane to the nucleus, results in incomplete proliferative T- cell responses to antigenic stimuli, while a lack of?
cord-015021-pol2qm74There are reports of nentrophil dysfunction in inflammatory disorders of the skin( 2), Are there dysfunctions concerning the unspecific host defense in SIRS, as well?
cord-015021-pol2qm74This has not happened, however, and the question is"Why not"?
cord-015021-pol2qm74This might be due to a preexisting( genetic?) or more likely to an epiphenomenal receptor defect.
cord-015021-pol2qm74We have investigated the proinflaznmatory oytokine secretion patter~ by PMN in patients following major~hermal or tra~ matic injury and in volunteers fellowinq endotoxemia.?
cord-015021-pol2qm74What are the definitions?
cord-015021-pol2qm74What are the issues, then, in 1994, to be dealt with at this symposium and congress?
cord-015021-pol2qm74What are the mechanisms?
cord-015021-pol2qm74What is the aplpiieability of study results in typical clinical situations?
cord-015021-pol2qm74What is the availability of speciftc antibiotics at a participating hospital?
cord-015021-pol2qm74Will the patient's physicians agree to the protocol choice?
cord-015021-pol2qm74Will they be helpful in the study and esro of patients?
cord-015021-pol2qm74Will this contribute to better clinical trials, information basis and better research?
cord-015021-pol2qm74Will we benefit Oleo from a more precise classification and definition of a non- outjty, a hodgu- podge of human disorders which have charsmeristic.s and manifestations of tissue injury, inflammation and infactian?
cord-015021-pol2qm74and?-IFN and T- helper-2( Th2) acting principally in inducing antibody formation with a secretion of IL-4, IL-5, IL-10 and TNF-[3 has still to be established within the context of major trauma.
cord-015021-pol2qm74anti- IFN-?( p<0.05).
cord-015021-pol2qm74or is it better to use a specific model for each trial?
cord-015021-pol2qm74~is s?.
cord-022404-cz3ruqxx8 Hamsters are prone to periodontal disease and dental caries, and any facial abscess located ventral or cranial to the eye may be a tooth root abscess.'? cord-022404-cz3ruqxx In some rabbits, abscesses continue to recur in the same spot or at some other sites in an apparently healthy individual.'?
cord-022404-cz3ruqxxRabbits are also susceptible to P. ovis( cattle and sheep).'? cord-022404-cz3ruqxx 10, 17 Demodex criceti and D. aurati are both normal residents of hamster skin.!? cord-022404-cz3ruqxx 16 Dermatophytosis in guinea pigs is an important zoonosis.!? cord-022404-cz3ruqxx 17, 33 Most previously diagnosedbasal cell tumors"were probably sebaceous epitheliomas.l?
cord-022404-cz3ruqxx2, 17 Riboflavin deficiency produces alopecia, scaling, and dermatitis, which are most evident on the extremities.s 17 Pyridoxine deficiency results in generalized alopecia and depigmentation of the haircoat.v 17 Niacin deficiency produces a generalized alopecia.v 17 Fatty acid deficiency results in generalized alopecia, scaling, and the production of profuse amounts of cerumen.v 17 Copper deficiency results in alopecia and depigmentation.f Foreign body granulomas associated with bedding consisting of wood shavings and sawdust were reported on the paws and the shoulders of hamsters.!?
cord-022404-cz3ruqxx2, 4, 17 Poxvirus infection has been described in laboratory white rats.!?
cord-022404-cz3ruqxxA modified live T. mentagrophytes vaccine may prove useful in prophylaxis.!?
cord-022404-cz3ruqxxA sparse haircoat and a bald tail were reported in association with an interstitial cell carcinoma of the testicle in one ferret.!?
cord-022404-cz3ruqxxAlopecia areata was reported in DEBR rats and proposed as a useful model of the human disease."?
cord-022404-cz3ruqxxAn exfoliative dermatitis resembling staphylococcal scalded skin syndrome was reported in a guinea pig colony, chiefly among female animals in the late stages of gestation.!?
cord-022404-cz3ruqxxAn outbreak of otitis extema and pinnal necrosis in association with mites( Otodectes?) and yeast( Malassezia?)
cord-022404-cz3ruqxxAn outbreak of otitis extema and pinnal necrosis in association with mites( Otodectes?) and yeast( Malassezia?)
cord-022404-cz3ruqxxDoes in heat and rabbits on low- fiber diets may barber their own hair.'?
cord-022404-cz3ruqxxFerrets can be experimentally infected with Dracunculus insignis and have been used as an animal model for studying dracunculiasis.t?
cord-022404-cz3ruqxxFipronil spray was reported to be effective.?'
cord-022404-cz3ruqxxFleas( especially Ctenocephalides felis felis) are commonly found on ferrets.'?
cord-022404-cz3ruqxxFrequent bathing may strip essential oils from the skin, resulting in keratinization disorders and pruritus.!?
cord-022404-cz3ruqxxHereditary alopecias( Fig. 21-21) are rarely described in rabbits'?
cord-022404-cz3ruqxxHereditary hairlessness has been reported in hamsters.!?
cord-022404-cz3ruqxxHowever, clinical signs recur with increasing severity each spring and eventually persist.l? 17, 43 Most affected males and females have a strong musky odor.
cord-022404-cz3ruqxxI?
cord-022404-cz3ruqxxIn the wild, chinchillas keep their haircoats clean and healthy by bathing in fine volcanic dust.!?
cord-022404-cz3ruqxxIntact females may pull out hair to use as bedding.'?
cord-022404-cz3ruqxxIvermectin may also be effective.'?
cord-022404-cz3ruqxxLice are most commonly found on the dorsum and may produce intense pruritus, Severe infestations in debilitated animals may produce anemia, weakness, emaciation, and death, H. ventricosus is a vector of tularemia, Therapy is the same as that described for cats, Demodex cuniculi mites have been isolated from rabbits with generalized pruritus and scaling, but their pathogenic significance is in doubt.!?
cord-022404-cz3ruqxxMedical treatment has been used, usually unsuccessfully, when surgery could not be performed, or when, after surgical removal of a neoplastic adrenal, the remaining adrenal gland also became neoplastic and clinical signs recurred.!?
cord-022404-cz3ruqxxMyxomatosis appeared in the depilated skin of Angora rabbits.'?
cord-022404-cz3ruqxxOne author reported treating over 50 rabbits with fipronil spray( 3 mllkg) with no adverse effects.??
cord-022404-cz3ruqxxOne author reported treating over 50 rabbits with fipronil spray( 3 mllkg) with no adverse effects.??
cord-022404-cz3ruqxxPoxvirus- like virions were demonstrated during the electron microscopic examination of specimens from two guinea pigs with a chronic, crusting cheilitis."?
cord-022404-cz3ruqxxRats are more resistant to experimental wound infection with S. aureus than are mice or hamsters.!?
cord-022404-cz3ruqxxRats may also rub the hair off the muzzle as they stick their face through slotted feeders or wire bars.!?
cord-022404-cz3ruqxxS. scabiei, T. caviae, and Ornithonyssus bacoti are reported to be rare causes of pruritus and dermatitis in hamsters.'?
cord-022404-cz3ruqxxSelf- inflicted facial excoriations( burrowing) may be seen in ferrets that have inadequate bedding, nesting material, or hiding spots.'?
cord-022404-cz3ruqxxSubmandibular and periorbital granulomas were associated with bacterial pseudomycetuna( botryomycosis) due to S. aureusl?
cord-022404-cz3ruqxxSystemic hair embolism has been reported subsequent to intravenous injections in rats.!?
cord-022404-cz3ruqxxThe barbered rabbit typically has patches of broken- off hairs over the head and back.'?
cord-022404-cz3ruqxxThese two attributes make the use of drainage, drains, and topical and systemic antibiotics unsuccessful in most cases.v-10, 15 The treatment of choice is surgical excision and at least 2 weeks of antibiotic treatment( see Table 21-1).10, 15, 81 If this is impossible, radical debridement, flushing, and antibiotics for several weeks may be effective.?
cord-022404-cz3ruqxxTicks may occasionally be found on ferrets, especially around the head and the ears.!?
cord-022404-cz3ruqxxTotal body alopecia and pruritus were reported in association with a testicular Sertoli's cell neoplasm in another ferret.'?
cord-022404-cz3ruqxxTreatment is accomplished with topical acaricides or topical ivermectin( 500 JLg/ kg divided between the two ears);'?
cord-022404-cz3ruqxxroutine wound care, and occasionally, administration of systemic antibiotics, Prevention and control are aimed at eliminating contact with the warble fly, Flystrike( maggots) is most commonly seen in the perineal region, and may spread dorsally onto the rump.!?
cord-022404-cz3ruqxxthis regard.n, 18 In one report.v?
cord-017208-7oew461e( For replication- selective vectors, what is the molecular basis of the selectivity and the conditions under which the vector would replicate?)
cord-017208-7oew461eAre alternative methods of selection available?
cord-017208-7oew461eAre data available evaluating the genetic stability of the recombinant vector?
cord-017208-7oew461eAre data available evaluating the potential for genetic recombination with other organisms in the patient or in the environment?
cord-017208-7oew461eAre the biological features of the vector, and its transgene when applicable, clearly similar in the animal species used for safety studies and in the human, at least as far as this can be ascertained?
cord-017208-7oew461eAre there any safety issues connected with the production, purification, and/or handling of the product?
cord-017208-7oew461eAre there issues of formulation that must be resolved?
cord-017208-7oew461eAre there reproducible assays for the product?
cord-017208-7oew461eCan successive batches of the material be made reproducibly in the quantity to support clinical development, and how is this known?
cord-017208-7oew461eDo you have any information regarding the estimated costs of this production project?
cord-017208-7oew461eDoes the construct contain an antibiotic resistance gene or other selectable marker?
cord-017208-7oew461eDoes the vector have an altered cell tropism?
cord-017208-7oew461eFor example, are the safety issues primarily related to the vector, the transgene product, the method of administration, the formulation/ excipient, or some combination of the above?
cord-017208-7oew461eFor example, would there be an advantage to performing the studies in rodents when larger numbers of animals might be more practical, or is there a necessity for a large animal model, such as a canine or nonhuman primate?
cord-017208-7oew461eHas a source of funding been identified for performing the clinical trial with this product?
cord-017208-7oew461eHas this construct been sequenced?
cord-017208-7oew461eHas this material been produced in a related or other production system?
cord-017208-7oew461eHas this material ever been produced for laboratory or clinical studies using this production system?
cord-017208-7oew461eHave there been any meetings scheduled with regulatory agencies, such as a pre- IND meeting with the FDA or a presentation to the NIH RAC?
cord-017208-7oew461eHave you identified any possible sources of production with any commercial firms?
cord-017208-7oew461eHow does one know that a lot of product is qualified for use?
cord-017208-7oew461eHow does this scale to anticipated quantities for clinical trial?
cord-017208-7oew461eHow might existing published or unpublished nonclinical or clinical data address the questions mentioned above?
cord-017208-7oew461eHow much material is available as a reference standard?
cord-017208-7oew461eHow will the presence and distribution of the gene therapy agent be followed in the patient?
cord-017208-7oew461eIf nonhuman primate studies are proposed, is it clear that another large animal or rodent model would not provide the same information?
cord-017208-7oew461eIf not, is there a qualified cell line available for propagation of this vector?
cord-017208-7oew461eIf you have had a pre- IND or RAC meeting, were any issues concerning manufacturing, safety, or stability raised that will have an impact on producing your product?
cord-017208-7oew461eIn broad strokes, these involve approaches to answering the following questions: Is the identity of the agent clearly defined?
cord-017208-7oew461eIn what form( lyophilized, formulated product, and so on) and fill size is the desired final product?
cord-017208-7oew461eIs material available as bulk biological substance for preliminary pharmacology and toxicology studies?
cord-017208-7oew461eIs the organism currently grown in a qualified cGMP cell line?
cord-017208-7oew461eIs the vector replication competent or replication defective?
cord-017208-7oew461eIs there a cGMP- qualified virus seed bank?
cord-017208-7oew461eIs there a danger of producing directly( as the therapeutic agent itself) or indirectly( through recombination and/or replication) an infectious agent that acts horizontally in the population or vertically across generations?
cord-017208-7oew461eIs toxicity after repeated doses of agent likely to be attenuated or magnified by immunological response to the agent?
cord-017208-7oew461eSome of the questions that should be answered by preclinical pharmacology/ toxicology studies are the following( 43): What is the relationship of the dose to the biologic activity?
cord-017208-7oew461eWas the cell line genetically modified to support this vector?
cord-017208-7oew461eWhat are the consequences of long- term presence of the therapeutic agent in the recipient?
cord-017208-7oew461eWhat are to be the release criteria for the product?
cord-017208-7oew461eWhat dose is likely to be required for therapeutic effect?
cord-017208-7oew461eWhat is known about the product stability with respect to physical integrity and activity?
cord-017208-7oew461eWhat is the average yield of the production system before and after purification?
cord-017208-7oew461eWhat is the desired final product formulation?
cord-017208-7oew461eWhat is the effect of altered tropism on anticipated host toxicity? 6.
cord-017208-7oew461eWhat is the largest amount of material that you have produced in your laboratory in a single production batch?
cord-017208-7oew461eWhat is the relationship of the dose to the toxicity?
cord-017208-7oew461eWhat is the status of the product(s) regarding intellectual property issues?
cord-017208-7oew461eWhat level of gene expression or replication is necessary to attain a therapeutic effect?
cord-017208-7oew461eWhat risks can be identified for the clinical trial?
cord-017208-7oew461eWhen toxicity occurs because of the agent, what is the evidence the toxicity will be reversible?
cord-017208-7oew461eWho will sponsor the IND for the proposed study?
cord-017208-7oew461eWhy was the proposed selection chosen?
cord-017208-7oew461eWould there be any utility in a genetically deficient model, and would this deficient model be more relevant to the proposed study either because of the potential for adverse immunologic consequences or because of the biological effects in the deficient condition?
cord-017208-7oew461eand/or rates of reversion to either wild- type or alternate viral genomes?
cord-017208-7oew461eand/or toxicity?
cord-026031-hnf5vaydAny cleaning products used inside or outside the house within the last 48 hours?
cord-026031-hnf5vaydAny construction work or renovation recently?
cord-026031-hnf5vaydAny fertilizers or weed killer used in the last week?
cord-026031-hnf5vaydAny mouse or rat poison in your house, yard, or garage?
cord-026031-hnf5vaydAre there any abnormal postures?
cord-026031-hnf5vaydAre there any characteristic odors on the breath?
cord-026031-hnf5vaydAre there any other abnormal signs that you have seen?
cord-026031-hnf5vaydAre there any pulse deficits or dysrhythmias auscultated?
cord-026031-hnf5vaydAre there any traces of foreign material on the tongue or in the crevices of the teeth or gums?
cord-026031-hnf5vaydAre there petechiae or ecchymosis on the gums or bleeding from the gumline?
cord-026031-hnf5vaydDid the owner attempt any irrigation or medical techniques prior to presentation?
cord-026031-hnf5vaydDid you give any medications to your animal?
cord-026031-hnf5vaydDid you witness the ingestion or exposure?
cord-026031-hnf5vaydDid your pet eat this morning or last night?
cord-026031-hnf5vaydDo the intestinal loops feel normal, or are they fluid- filled or gas- filled?
cord-026031-hnf5vaydDo you have any over- the- counter or prescription medications that your animal may have had access to?
cord-026031-hnf5vaydDo you have the container with you today?
cord-026031-hnf5vaydDo you hear harsh airway sounds or pulmonary crackles?
cord-026031-hnf5vaydDo you observe any ptyalism or attempts to vomit?
cord-026031-hnf5vaydDo you think that the signs have been the same, better, or getting worse?
cord-026031-hnf5vaydDoes it appear lethargic or hyperactive?
cord-026031-hnf5vaydDoes the animal have access to any poisonous substances?
cord-026031-hnf5vaydDoes your animal have access to any known toxins, or does he or she run loose unattended?
cord-026031-hnf5vaydDoes your animal have any ongoing or past medical problems?
cord-026031-hnf5vaydDoes your animal run loose outdoors unattended?
cord-026031-hnf5vaydDoes your pet have access to a compost pile?
cord-026031-hnf5vaydDoes your pet have access to neighboring properties( even for a short time)?
cord-026031-hnf5vaydDoes your pet run loose unattended?
cord-026031-hnf5vaydFor example, is the patient retaining bicarbonate( metabolic alkalosis) because of carbon dioxide retention( respiratory acidosis)?
cord-026031-hnf5vaydHas it changed at all since the owner noticed the problem?
cord-026031-hnf5vaydHas there been any gardening work recently?
cord-026031-hnf5vaydHas there been any prior incident of ocular disease?
cord-026031-hnf5vaydHas your animal been on any medications recently or currently?
cord-026031-hnf5vaydHas your animal been vaccinated recently?
cord-026031-hnf5vaydHas your animal had any previous or similar episodes?
cord-026031-hnf5vaydHas your pet been off your property in the last 24- 48 hours?
cord-026031-hnf5vaydHas your pet been to rural areas in the last week?
cord-026031-hnf5vaydHas your pet had any antiflea/ tick medication within the last week?Your pet's environment Is your animal kept inside or outside of the house?
cord-026031-hnf5vaydHas your pet traveled outside of your immediate geographic location?
cord-026031-hnf5vaydHave any known relatives of your animal had any bleeding disorders?
cord-026031-hnf5vaydHave similar signs occurred in the past?
cord-026031-hnf5vaydHave the signs become better or worse since you first saw them?
cord-026031-hnf5vaydHave you changed your radiator fluid or does a car leak antifreeze?
cord-026031-hnf5vaydHave you fed table scraps or anything new recently?
cord-026031-hnf5vaydHow fast did the clinical signs develop?
cord-026031-hnf5vaydHow is the patient acting?
cord-026031-hnf5vaydHow long ago do you think that your pet was exposed to the poison?
cord-026031-hnf5vaydHow long ago was the exposure?
cord-026031-hnf5vaydHow long has the animal been acting that way?
cord-026031-hnf5vaydHow much did the animal consume?
cord-026031-hnf5vaydHow soon did other signs develop?
cord-026031-hnf5vaydIf so, what?
cord-026031-hnf5vaydIf so, when and how much did your animal consume?
cord-026031-hnf5vaydIf so, when?
cord-026031-hnf5vaydIf so, which?
cord-026031-hnf5vaydIs abdominal palpation painful?
cord-026031-hnf5vaydIs it a liquid concentrate, dilute spray, or solid?
cord-026031-hnf5vaydIs it fast, normal, or slow?
cord-026031-hnf5vaydIs it moist, dry, bubbling, or frothy, or caked with dirt?
cord-026031-hnf5vaydIs it normal and pink, or dark red( injected), pale, or icteric?
cord-026031-hnf5vaydIs it normal, fast, shallow, or labored?
cord-026031-hnf5vaydIs it synchronous with the heart rate, or are there dropped pulses?
cord-026031-hnf5vaydIs the animal ambulatory, and if so, do you observe any gait abnormalities?
cord-026031-hnf5vaydIs the lens clear and is it in the normal position?
cord-026031-hnf5vaydIs the ocular examination normal?
cord-026031-hnf5vaydIs the pulse bounding, normal, thready, or not palpable?
cord-026031-hnf5vaydIs there a P wave for every QRS, and a QRS for every P wave?
cord-026031-hnf5vaydIs there a chance that your pet may have gotten into the garbage?
cord-026031-hnf5vaydIs there a palpable urinary bladder?
cord-026031-hnf5vaydIs there any history of trauma or known chemical irritant or exposure?
cord-026031-hnf5vaydIs there any possibility of any toxin exposure?
cord-026031-hnf5vaydIs there any possibility of trauma?
cord-026031-hnf5vaydIs there any vomiting, diarrhea, trembling, or seizures?
cord-026031-hnf5vaydIs there evidence of vomiting or diarrhea?
cord-026031-hnf5vaydIs there excessive salivation?
cord-026031-hnf5vaydIs there respiratory distress?
cord-026031-hnf5vaydIs there urine production?
cord-026031-hnf5vaydIs your animal able to walk?
cord-026031-hnf5vaydIs your animal breathing or does it have respiratory difficulty?
cord-026031-hnf5vaydIs your pet kept in a fenced- in yard or allowed to run loose unattended?
cord-026031-hnf5vaydIt is useful to phrase questions in a neutral fashion- for example,"Is such- and- such present on the premises?"
cord-026031-hnf5vaydWas the substance swallowed, or is it on the animal's skin or eyes?
cord-026031-hnf5vaydWhat clinical signs developed?
cord-026031-hnf5vaydWhat do you hear on thoracic auscultation?
cord-026031-hnf5vaydWhat is the animal's activity level?
cord-026031-hnf5vaydWhat is the capillary refill time?
cord-026031-hnf5vaydWhat is the color and consistency of the feces?
cord-026031-hnf5vaydWhat is the color of the gums or tongue?
cord-026031-hnf5vaydWhat is the color of the urine?
cord-026031-hnf5vaydWhat is the mucous membrane color?
cord-026031-hnf5vaydWhat is the name of the product?
cord-026031-hnf5vaydWhat is the nature of the bleeding?
cord-026031-hnf5vaydWhat is the patient's blood pressure?
cord-026031-hnf5vaydWhat is the patient's electrocardiogram?
cord-026031-hnf5vaydWhat is the patient's heart rate?
cord-026031-hnf5vaydWhat is the patient's rectal temperature?
cord-026031-hnf5vaydWhat is the patient's respiratory character?
cord-026031-hnf5vaydWhat is the patient's respiratory rate?
cord-026031-hnf5vaydWhat is the pupil reactivity to light?
cord-026031-hnf5vaydWhat is the pupil size?
cord-026031-hnf5vaydWhat is the quality of the femoral pulse?
cord-026031-hnf5vaydWhat is the sensitivity to light or sound?
cord-026031-hnf5vaydWhat is the substance that your animal ingested( was exposed to)?
cord-026031-hnf5vaydWhat is your chief complaint or reason that you brought your animal in on emergency?
cord-026031-hnf5vaydWhat other conditions have developed and what are they?
cord-026031-hnf5vaydWhat sites are affected?
cord-026031-hnf5vaydWhat was the first abnormal sign noticed?
cord-026031-hnf5vaydWhen did the signs first start, or when was your animal last normal?
cord-026031-hnf5vaydWhen did you first notice that something was wrong with your pet?
cord-026031-hnf5vaydWhen was the animal last seen as normal?
cord-026031-hnf5vaydWhen was the last time you noticed your pet act normally?
cord-026031-hnf5vaydWhen was the onset of clinical signs?
cord-026031-hnf5vaydWhen was the problem first noticed?
cord-026031-hnf5vaydWhere do you think it happened?
cord-026031-hnf5vaydWhere has your pet been in the last 24 hours?
cord-026031-hnf5vaydif so, where?
cord-026031-hnf5vaydor When was the last time you saw your animal act normally?
cord-026031-hnf5vaydrather than"Could the dog have eaten such- and- such?"
cord-026031-hnf5vaydshe normally fed?
cord-026031-hnf5vayd• How long has the bleeding been going on?