bigram

This is a table of type bigram and their frequencies. Use it to search & browse the list to learn more about your study carrel.

bigram	frequency
acute respiratory	204
respiratory syndrome	133
severe acute	131
novel coronavirus	131
coronavirus disease	126
immune response	122
lung injury	106
immune system	105
respiratory distress	97
converting enzyme	97
severe covid	95
cytokine storm	93
spike protein	93
med hypotheses	91
doc id	87
hypotheses doi	87
cord uid	87
oxidative stress	82
distress syndrome	80
syndrome coronavirus	79
endothelial cells	75
epithelial cells	61
inflammatory cytokines	60
immune cells	58
innate immune	54
nitric oxide	46
viral infection	46
inflammatory response	45
immune responses	44
viral infections	42
acute lung	42
clinical characteristics	42
virus infection	41
risk factors	41
hydrogen peroxide	40
host cells	40
influenza virus	39
ace receptor	38
critically ill	38
clinical trials	38
may also	37
respiratory tract	36
endothelial dysfunction	35
systematic review	33
cardiovascular disease	32
viral load	32
angiotensin ii	32
endothelial cell	31
blood group	30
air pollution	30
intensive care	30
ang ii	30
patients infected	30
ill patients	29
host cell	29
public health	29
angiotensin system	29
inflammatory cytokine	29
vascular endothelial	28
angiotensin converting	28
innate immunity	28
sars coronavirus	28
east asia	28
type diabetes	27
infected patients	26
important role	26
clinical course	26
necrosis factor	26
severe cases	26
viral replication	26
diabetes mellitus	25
lung inflammation	25
cell entry	25
binding protein	25
abo blood	25
coronavirus pneumonia	24
new coronavirus	24
hospitalized patients	24
nlrp inflammasome	24
authors declare	24
tumor necrosis	24
blood vessels	23
human coronavirus	23
alveolar epithelial	23
bcg vaccination	23
inflammatory responses	22
side effects	22
nuclear factor	22
type i	22
infectious diseases	22
corona virus	22
vascular thrombosis	21
surface tension	21
valproic acid	21
cell surface	21
adaptive immune	21
world health	21
ocular surface	21
health organization	21
proinflammatory cytokines	20
oxygen species	20
reactive oxygen	20
viral entry	20
cell signaling	20
adipose tissue	20
clinical features	19
vascular endothelium	19
type ii	19
nervous system	19
inflammatory mediators	19
serine protease	19
induced lung	19
pulmonary surfactant	18
dendritic cells	18
potential therapeutic	18
increased risk	18
mortality rate	18
high risk	18
pulmonary surfactants	18
liquid crystalline	18
million people	18
disease severity	18
cell death	18
severe disease	18
control measures	18
mechanical ventilation	17
clinical trial	17
high levels	17
may lead	17
stem cells	17
alveolar cells	17
mesenchymal stem	17
ace ace	17
cytokine production	17
pulmonary disease	17
united states	17
growth factor	17
systemic inflammation	17
coronavirus infection	17
protein kinase	17
sars cov	17
may cause	17
respiratory failure	16
ace expression	16
male reproductive	16
male patients	16
cov infection	16
hong kong	16
rheumatoid arthritis	16
receptor binding	16
cytokine release	16
crystalline phase	16
blood cells	16
risk factor	16
receptor ace	15
heart failure	15
blood pressure	15
rna viruses	15
human ace	15
upper respiratory	15
liver injury	15
singlet oxygen	15
infected cells	15
sialic acid	15
blood coagulation	15
also known	15
health care	15
infected people	15
cell proliferation	15
respiratory system	15
phase transition	15
central nervous	15
cell types	15
cell lines	15
mount etna	15
surface viscosity	15
hpa axis	15
night shift	15
respiratory infections	14
organ failure	14
suppressor cells	14
peripheral blood	14
heavy metals	14
adaptive immunity	14
observational study	14
neutrophil extracellular	14
medical staff	14
endothelial damage	14
respiratory diseases	14
endothelial function	14
coronavirus infections	14
extracellular traps	14
metabolic syndrome	14
expressing cells	14
protease inhibitor	14
clinical studies	14
randomized controlled	14
spike glycoprotein	13
icu patients	13
middle east	13
viral spike	13
microvascular thrombosis	13
signaling pathway	13
binding domain	13
drug interactions	13
laden macrophages	13
septic shock	13
shift work	13
severe forms	13
lipid metabolism	13
organ dysfunction	13
neutrophil elastase	13
peroxisome proliferator	13
lung damage	13
cohort study	13
blood clots	13
cd mdsc	13
infectious disease	13
protective effect	13
respiratory disease	13
pulmonary edema	13
activated receptor	13
personal relationships	13
care unit	13
animal models	13
thrombin generation	13
inflammatory effects	13
macrophage activation	13
high mortality	13
global health	13
new york	13
allium sativum	13
crucial role	13
relative humidity	13
burnout syndrome	13
central europe	12
chronic obstructive	12
infectious agents	12
infected pneumonia	12
th cells	12
antiviral activity	12
host immune	12
mobility group	12
bone marrow	12
drug delivery	12
highly expressed	12
murine models	12
case series	12
known competing	12
several studies	12
coagulation cascade	12
older adults	12
receptor expression	12
coronavirus spike	12
thrombotic complications	12
competing financial	12
cytokine secretion	12
social distancing	12
fine pm	12
well known	12
pathological findings	12
may play	12
ace receptors	12
poor prognosis	12
severe sars	12
recent study	12
key role	12
associated lung	12
ace deficiency	12
elevated levels	12
syncytial virus	11
immunodeficiency virus	11
carbohydrate interactions	11
kidney disease	11
china clinical	11
higher risk	11
viral rna	11
high mobility	11
systemic inflammatory	11
alveolar type	11
respiratory droplets	11
tobacco mosaic	11
also reported	11
east respiratory	11
hyperinflammatory response	11
consumptive coagulopathy	11
lung tissue	11
higher mortality	11
preterm labor	11
fatality rate	11
early stage	11
activated charcoal	11
financial interests	11
venous thromboembolism	11
gc protein	11
qt interval	11
ace expressing	11
lymphatic vessels	11
protease tmprss	11
willebrand factor	11
severe respiratory	11
ebola virus	11
human immunodeficiency	11
simplex virus	11
cell exhaustion	11
testosterone levels	11
herpes simplex	11
tissue factor	11
icu admission	11
ill covid	11
inhibitory effect	11
particulate matter	11
lung disease	11
inflammatory state	11
higher levels	11
platelet aggregation	11
obstructive pulmonary	11
entry receptor	11
mosaic virus	11
reproductive function	11
pulmonary vascular	11
respiratory syncytial	11
oral mucosa	10
european countries	10
alveolar damage	10
smooth muscle	10
mortality rates	10
lymphatic system	10
alveolar macrophages	10
factors associated	10
case fatality	10
wide range	10
entry depends	10
knockout mice	10
blood flow	10
plasma membrane	10
staphylococcus aureus	10
free dna	10
severe stages	10
target cells	10
derived suppressor	10
membrane fusion	10
multiple organ	10
work reported	10
activating factor	10
intraalveolar lipid	10
von willebrand	10
may result	10
medical residents	10
exhaled breath	10
pregnant women	10
adverse effects	10
transcription factor	10
clinically proven	10
convalescent plasma	10
tissue damage	10
cell infection	10
reductase inhibitors	10
tissue injury	10
tlr activation	9
clinical outcomes	9
squamous cell	9
currently available	9
exogenous surfactant	9
small intestine	9
line tension	9
cell culture	9
release syndrome	9
hmgb antibodies	9
activated protein	9
randomized clinical	9
east asian	9
proven protease	9
gene expression	9
extracellular matrix	9
liver disease	9
respiratory viral	9
group box	9
high expression	9
main protease	9
clinical symptoms	9
receptor antagonist	9
may contribute	9
cystic fibrosis	9
safety profile	9
cd cells	9
inflammatory effect	9
respiratory symptoms	9
deleterious effects	9
phase separation	9
clinical data	9
stranded rna	9
ace activity	9
renal function	9
pulmonary fibrosis	9
cell membrane	9
infection may	9
diabetic patients	9
trained immunity	9
fine particulate	9
therapeutic strategies	9
shift workers	9
lithium chloride	9
lower respiratory	9
mild symptoms	9
garlic extract	9
viral components	9
reactive protein	9
oral cancer	9
plasminogen activator	9
controlled trials	9
ncov infection	9
mevalonate pathway	9
rna virus	9
retrospective cohort	9
reproductive system	9
extrahepatic vitamin	9
increased mortality	9
angiotensin i	9
face masks	9
chinese herbal	9
specific antibodies	9
immune fitness	8
functional receptor	8
coronavirus nl	8
like receptor	8
previous studies	8
severely ill	8
severe symptoms	8
also found	8
family history	8
protective equipment	8
east asians	8
mesentery fat	8
inflammatory storm	8
metabolizing enzymes	8
signaling pathways	8
taurine chloramine	8
care workers	8
transmembrane protease	8
traditional chinese	8
may explain	8
influenza viruses	8
serum albumin	8
potential role	8
natural killer	8
diabetic nephropathy	8
enzyme activity	8
infected individuals	8
chronic exposure	8
regulating autophagy	8
inflammatory properties	8
observational studies	8
serum levels	8
case report	8
myocardial infarction	8
cell apoptosis	8
inflammasome pathway	8
blood clotting	8
covid virus	8
cell carcinoma	8
protein fragment	8
relatively high	8
fatty acid	8
tract infections	8
york city	8
air quality	8
hemorrhagic consumptive	8
new cases	8
dry cough	8
associated molecular	8
retrospective study	8
significant increase	8
therapeutic agent	8
invasive ventilation	8
aat inhibits	8
asian countries	8
surfactant protein	8
lung epithelial	8
oxide synthase	8
hospitalized covid	8
pulmonary system	8
amino acid	8
high concentration	8
protease enzyme	8
cov spike	8
chronic kidney	8
adult inpatients	8
sars patients	8
cytokines il	8
serum testosterone	8
lung pathology	8
healthy subjects	8
free area	8
death rate	8
muscle cells	8
skeletal muscle	8
respiratory virus	8
virus particles	8
fatty acids	8
circadian rhythms	8
long term	8
nk cells	8
signalling pathways	8
oral squamous	7
aldosterone system	7
human vascular	7
injury induced	7
endothelial injury	7
coronavirus sars	7
glutathione levels	7
treg th	7
red blood	7
lung function	7
glucose metabolism	7
cardiac injury	7
severe lung	7
high concentrations	7
gases emitted	7
study showed	7
years old	7
may affect	7
droplet size	7
redox status	7
high level	7
inflammatory cells	7
mediated cell	7
older people	7
cell cultures	7
high prevalence	7
intestinal permeability	7
bat origin	7
patients may	7
pneumonia outbreak	7
dendritic cell	7
monoclonal antibody	7
drug interaction	7
new therapeutic	7
storm syndromes	7
male reproduction	7
probable bat	7
product use	7
structural basis	7
induced oxidative	7
interferon response	7
cells may	7
enveloped virus	7
pivotal role	7
like receptors	7
visceral adipose	7
lateral phase	7
gastrointestinal tract	7
clinical manifestations	7
diffuse alveolar	7
herbal remedies	7
ace inhibitors	7
physical activity	7
respiratory infection	7
inflammation induced	7
glioma cells	7
virus disease	7
disease progression	7
ii receptor	7
taken together	7
immune dysregulation	7
blood type	7
people infected	7
immune function	7
airborne transmission	7
coronary artery	7
cu ions	7
cell injury	7
free cholesterol	7
abnormal coagulation	7
outbreak associated	7
progenitor cells	7
macrophage activating	7
poor outcomes	7
pathological conditions	7
cell line	7
lung cancer	7
descriptive study	7
endothelial growth	7
cell membranes	7
consider cytokine	7
endothelial nitric	7
south east	7
direct correlation	7
molecular mechanisms	7
inflammatory markers	7
immune defence	7
rapid spread	7
human transmission	7
virus rna	7
global pandemic	7
cell damage	7
risk individuals	7
leydig cells	7
ventilated patients	7
heart disease	7
controlled trial	7
first case	6
circulating levels	6
null allele	6
first step	6
hypothesis suggests	6
viral particles	6
active property	6
worse prognosis	6
another study	6
cov virus	6
therapeutic effect	6
chronic diseases	6
viral protein	6
receptor blockers	6
clinical study	6
reproduction number	6
health emergency	6
disease model	6
phase boundaries	6
ace signaling	6
mycobacterium tuberculosis	6
disease caused	6
human airway	6
immune cell	6
virus origins	6
treg cells	6
beneficial effects	6
pathogenic role	6
evans blue	6
large number	6
system activation	6
nad levels	6
elderly patients	6
contact rate	6
interstitial lung	6
oral activated	6
risk group	6
significant role	6
trace elements	6
endoplasmic reticulum	6
damage caused	6
ii pneumocytes	6
binding affinity	6
may induce	6
second outbreak	6
infected persons	6
highly contagious	6
immunomodulatory effects	6
stimulating factor	6
might also	6
chronic inflammatory	6
cholesterol levels	6
clinical evidence	6
breath condensate	6
affects male	6
early endothelial	6
nh cl	6
reproductive ability	6
standing potential	6
although sars	6
findings suggest	6
neonatal respiratory	6
vitro studies	6
possible mechanism	6
epidemic curve	6
including il	6
enveloped viruses	6
tobacco smoking	6
pulmonary inflammation	6
monoclonal antibodies	6
vitamin derivative	6
gattii species	6
unmodified vitamin	6
central role	6
type alveolar	6
prostate cancer	6
bone destruction	6
widely available	6
leukotriene receptor	6
may provide	6
infection due	6
ace protein	6
new drugs	6
cardiovascular diseases	6
cellular immune	6
cryptococcus neoformans	6
binding site	6
induced apoptosis	6
lung diseases	6
hepatic cytochrome	6
inducible factor	6
clinical presentation	6
factors related	6
rat hepatocytes	6
angiotensin receptor	6
patients hospitalized	6
superoxide dismutase	6
viral respiratory	6
gas exchange	6
also showed	6
ii cells	6
airway epithelia	6
general population	6
high affinity	6
cellular entry	6
inflammasome activation	6
cu deficiency	6
rna polymerase	6
vascular endothelialitis	6
therapeutic agents	6
nerve stimulation	6
molecular patterns	6
literature review	6
financial support	6
ace mediated	6
coronavirus outbreak	6
human cells	6
essential role	6
biological system	6
virus infections	6
benign prostatic	6
cell receptor	6
acetate may	6
blood cell	6
high altitude	6
rna synthesis	6
blood groups	6
organ damage	6
antiviral effect	6
therapeutic effects	6
amino acids	6
coagulation parameters	6
male fertility	6
recent studies	6
neurodegenerative diseases	6
much higher	6
perinasal lymphatic	6
cell activation	6
related coronavirus	6
factor receptors	6
higher prevalence	6
lung fibrosis	6
type interferon	6
bacterial infection	6
glycogen synthase	6
viral clearance	6
human alveolar	6
also called	6
low testosterone	6
control group	6
many studies	6
mouse model	6
response may	6
adverse reactions	6
virus replication	6
excessive inflammation	6
plasma levels	6
relatively low	6
allergic rhinitis	6
high incidence	6
inflammatory reaction	6
hyperimmune anti	6
virus binding	6
human immune	6
reaction product	6
aat inhibition	6
white blood	6
i interferon	6
antiviral drugs	6
statin therapy	6
increasing evidence	5
chloroquine phosphate	5
drug administration	5
novel drug	5
host defense	5
incubation period	5
driving force	5
cells will	5
cardiovascular cells	5
covert infection	5
among patients	5
neutrophil infiltration	5
stem cell	5
early treatment	5
group antibodies	5
cytokine levels	5
sialyl tn	5
glutathione synthesis	5
may facilitate	5
vascular function	5
higher level	5
climatic conditions	5
viral diseases	5
neutralizing antibodies	5
inflammatory protein	5
antioxidative property	5
receptor recognition	5
study covid	5
also inhibit	5
severe illness	5
dependent manner	5
cultured human	5
emmprin expression	5
early stages	5
greater risk	5
bone resorption	5
intestinal inflammation	5
heightened cytokine	5
critical role	5
effective treatment	5
respiratory disorders	5
cell receptors	5
may occur	5
novel angiotensin	5
critical care	5
oral nac	5
endothelial progenitor	5
macrophage inflammatory	5
ar signaling	5
new virus	5
rodent models	5
ill icu	5
aat deficiency	5
expansion cycling	5
killer cells	5
renin angiotensin	5
lopinavir ritonavir	5
microbial components	5
treatment protocols	5
viral sgp	5
meningeal lymphatic	5
approved drugs	5
major risk	5
study using	5
rna sequencing	5
th cell	5
hcq cq	5
cerebral immune	5
important lessons	5
barrier disruption	5
tobacco smoke	5
clinical outcome	5
surfactant administration	5
virucidal activity	5
tocopherol transfer	5
respiratory illness	5
ace ratio	5
well tolerated	5
lung compliance	5
lipid bilayer	5
theta defensins	5
cells decreased	5
glass opacity	5
surfactant function	5
viral genome	5
take place	5
nicotinamide adenine	5
respiratory burst	5
residency training	5
fusion protein	5
hypertonic ibuprofen	5
called cytokine	5
low serum	5
respiratory epithelium	5
close contact	5
outcomes among	5
proinflammatory mediators	5
virus type	5
reduced covid	5
vascular wall	5
cell recognition	5
immune modulation	5
human body	5
personal protective	5
targeted treatment	5
storm syndrome	5
pay attention	5
viral upper	5
right ventricular	5
proliferator activated	5
basic reproduction	5
infected subjects	5
administered prophylactically	5
epithelial cell	5
emergency unit	5
central obesity	5
second wave	5
lung epithelium	5
renal failure	5
oral cavity	5
length human	5
several factors	5
adenine dinucleotide	5
blood system	5
surface receptor	5
early phase	5
tb infections	5
respiratory compression	5
therapeutic potential	5
even though	5
lung infection	5
protein priming	5
human lung	5
animal studies	5
understanding sars	5
significantly increased	5
tubule cells	5
surface glycoprotein	5
hemorrhagic shock	5
experimental studies	5
medical errors	5
electrical charge	5
may prevent	5
activation syndrome	5
angiotensinconverting enzyme	5
asymptomatic infection	5
cascade thrombin	5
transfer protein	5
lower level	5
influenza pandemic	5
cell dysfunction	5
central european	5
free radicals	5
maillard reaction	5
cell function	5
cell rna	5
recycling rates	5
temporal evolution	5
contact parameter	5
genomic characterisation	5
promising therapeutic	5
hpa system	5
ii alveolar	5
antiviral effects	5
renal injury	5
sectional study	5
tmprss expression	5
underlying mechanisms	5
human respiratory	5
transmission dynamics	5
viral interference	5
even renal	5
factor ii	5
sars epidemic	5
activated platelets	5
mdsc populations	5
takes place	5
vascular cells	5
aerodynamic diameter	5
fatal disease	5
hypothesis date	5
related deaths	5
protease serine	5
poorer prognosis	5
care units	5
terminal domain	5
procoagulant activity	5
preventive measures	5
confirmed cases	5
covid patients	5
aerosol spray	5
temperate environments	5
cd rs	5
oxidant stress	5
epidemiological studies	5
protein interaction	5
among hospitalized	5
receptor antagonists	5
ptx dip	5
data show	5
mdsc cells	5
zika virus	5
cytokine storms	5
vascular damage	5
personal accomplishment	5
south korea	5
antiviral activities	5
influenza vaccine	5
herbal formulations	5
bronchitis virus	5
author declares	5
dimensional phase	5
late mediator	5
better understand	5
bone metabolism	5
disease states	5
edged sword	5
surgical masks	5
initial phase	5
abh antigens	5
increased severity	5
arterial hypertension	5
much lower	5
higher viral	5
viral loads	5
smaller particles	5
healthy adults	5
rna genome	5
also demonstrated	5
matrix metalloproteinase	5
innate response	5
gastroenteritis virus	5
covid pandemic	5
damaged cells	5
well documented	5
psychological effects	5
cell responses	5
factor xii	5
treat asthma	5
immune memory	5
per million	5
tissue distribution	5
increased levels	5
activator inhibitor	5
drinking water	5
infectious conjunctivitis	5
airway epithelial	5
related siglecs	5
renal transplant	5
mesenteric fat	5
insulin resistance	5
cd expression	5
prostatic hyperplasia	5
reference sequence	5
delivery systems	5
antigen presentation	5
worse outcomes	5
inflammatory drugs	5
human plasma	5
current outbreak	5
bacterial translocation	5
inflammatory bowel	5
expression may	5
epigallocatechin gallate	5
associated mortality	5
metabolic diseases	5
transplant recipients	5
exponentially increases	5
antioxidant activity	5
cyps activity	5
several clinical	5
induced interstitial	5
mortality due	5
commonly used	5
human endothelial	5
allele frequency	5
transmissible gastroenteritis	5
aged garlic	5
current pandemic	5
pulmonary hypertension	5
may increase	5
synthase kinase	5
controlled hypothermia	4
statistically significant	4
hypothesis will	4
pulmonary inflammatory	4
improves survival	4
antibody production	4
systemic oxidant	4
metalloproteinase inducer	4
specific adaptive	4
may drive	4
protective role	4
camp levels	4
emergency department	4
recombinant human	4
potential treatment	4
superoxide production	4
drug metabolism	4
thereby decreasing	4
termed coronavirus	4
bcg vaccine	4
short term	4
aat administered	4
natural origin	4
patients develop	4
physiological mechanisms	4
different phenotypes	4
new idea	4
infection via	4
coronavirus pandemic	4
grape seed	4
iv method	4
activity may	4
membrane biophysics	4
associated acute	4
induced obesity	4
malaria infection	4
people living	4
different cell	4
virus spread	4
rs cc	4
structural deviance	4
case reports	4
receptor alpha	4
lymph nodes	4
sore throat	4
analysis based	4
first two	4
inflammatory process	4
oxidative damage	4
treatment options	4
generation gcmaf	4
oral epithelial	4
human cyp	4
receptor molecules	4
coronavirus strain	4
disease progresses	4
potential targeted	4
potential conflict	4
ex vivo	4
error term	4
disease control	4
genetic variation	4
dependent rna	4
promising results	4
strenuous exercise	4
body weight	4
copper deficiency	4
cardiac disease	4
term infants	4
relatively lower	4
significantly higher	4
mechanisms involved	4
online ahead	4
superoxide anion	4
particle size	4
less susceptible	4
antiviral state	4
projection models	4
coronavirus receptor	4
icu stay	4
coagulation abnormalities	4
infections compared	4
cellular level	4
hepatic cyp	4
entry via	4
oxidant chloramine	4
close contacts	4
healthy controls	4
sirt activity	4
male sex	4
prone posturing	4
humoral immunity	4
coagulation factors	4
multiple viral	4
key molecule	4
primary factor	4
molecular mechanism	4
helper cells	4
human pulmonary	4
severe endothelial	4
zinc supplementation	4
hospital death	4
support corticosteroid	4
vascular injury	4
disseminated intravascular	4
enhanced thrombosis	4
vagal nerve	4
reduced numbers	4
inflammatory immune	4
inanimate surfaces	4
tissue eosinophilia	4
blood cholesterol	4
infections per	4
may predispose	4
human coronaviruses	4
risk assessment	4
creatine kinase	4
genomic sequence	4
risk groups	4
cell interaction	4
controlled clinical	4
proinflammatory cytokine	4
th century	4
hypoxia inducible	4
reducing sugars	4
induced activation	4
metabolic disorders	4
possible role	4
similar results	4
health measures	4
antitrypsin deficiency	4
health consequences	4
protein levels	4
glioma tumorogenesis	4
protease activity	4
various countries	4
asymptomatic infections	4
visceral fat	4
preliminary results	4
ang i	4
hepatic cyps	4
coronavirus oc	4
probably due	4
eastern flank	4
key step	4
atopic dermatitis	4
artery disease	4
cd hla	4
vascular disease	4
current literature	4
camp signalling	4
may worsen	4
times higher	4
cyps expression	4
poorly understood	4
ace shedding	4
transforming growth	4
natural course	4
aberrant ras	4
emergency response	4
also expressed	4
anticoagulant protein	4
model predicts	4
local inflammation	4
positive rate	4
inflammatory diseases	4
treating covid	4
older age	4
diarrhea virus	4
adenosine receptor	4
local innate	4
portal vein	4
without affecting	4
epoxide reductase	4
lipid droplet	4
march th	4
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ace inhibition	4
nalp inflammasome	4
resident doctors	4
tb infection	4
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cysteinyl leukotriene	4
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adenosine monophosphate	4
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hyaline membrane	4
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like syndrome	4
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birds eye	4
rat model	4
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cell count	4
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nm diameter	4
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current covid	4
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load per	4
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hiv infection	4
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epidemiological characteristics	4
small droplets	4
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th responses	4
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promising agent	4
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eliciting cell	4
important risk	4
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intracellular viral	4
positive patients	4
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many people	4
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human hepatocytes	4
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macrophage colony	4
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direct antiviral	4
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factor kappa	4
feedback cycle	4
also play	4
low density	4
therapeutic drug	4
cell response	4
many patients	4
i suggest	4
large amounts	4
human serum	4
soluble ace	4
displayed ps	4
via ace	4
leading cause	4
glucose levels	4
pulmonary sarcoidosis	4
secreted glycoprotein	4
health workers	4
aat may	4
antibody response	4
also reduced	4
therapeutic use	4
latin america	4
inhaled vitamin	4
three times	4
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scientific community	4
surgical mask	4
transcutaneous non	4
surfactant phospholipid	4
administered dose	4
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chromosomal protein	4
four hypotheses	4
cultured rat	4
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drug metabolizing	4
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tumor growth	4
clinically relevant	4
iv nac	4
future studies	4
phosphatidylcholine bilayers	4
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viral pathogens	4
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model saturated	4
bowel disease	4
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spike proteins	4
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normal human	4
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recombinant hdef	4
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may improve	4
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transcription factors	4
fragment theory	4
well understood	4
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cns infections	4
including sars	4
box chromosomal	4
intratracheal administration	4
via activation	4
different cyps	4
initial alarm	4
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salivary glands	4
allow us	4
critical patients	4
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antiviral agent	4
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bacillus calmette	4
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inflammatory lung	4
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molecular dynamics	4
activated macrophages	4
reduced morbidity	4
sunless tanning	4
leptin receptor	4
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health authorities	4
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esterified derivative	4
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ionic strength	4
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infection depend	4
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critical illness	4
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bridge adaptive	4
immunomodulatory properties	4
per droplet	4
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healthy volunteers	4
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lymphocyte ratio	4
lower levels	4
expression levels	4
contributable variable	4
named covid	4
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fulminant acute	4
atherosclerotic plaques	4
polymerase chain	4
inflammatory action	4
nutritional deficiencies	4
stromal cells	4
factor xa	4
repeated infections	4
ethyl pyruvate	4
related morbidity	4
invasive vagal	4
low occurrence	4
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chain reaction	4
known anti	4
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membrane formation	4
nadph oxidase	4
antitrypsin inhibits	4
nac may	4
inflammasome inhibition	4
based pharmacokinetic	4
organ specific	4
size distribution	4
universal bcg	4
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pulmonary embolism	4
surfactant preparations	4
sars pathogenesis	4
mrna levels	4
plasmodium falciparum	4
factor ixa	4
corticosteroid treatment	4
replacement therapy	4
surfactant dysfunction	4
long time	4
hypoxic pulmonary	4
young patients	4
siglec binding	4
proposed mechanism	4
multiorgan failure	4
plasma concentrations	4
two subunits	4
pathophysiologic processes	4
secretory phospholipase	4
respiratory pathogens	4
also associated	4
epidemiological study	3
safety data	3
active metabolite	3
one study	3
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pooled analysis	3
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intervention protocols	3
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superoxide anions	3
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markedly diminish	3
study endothelial	3
tenase complex	3
covid infection	3
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epidermal growth	3
state oxygen	3
cumulative number	3
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community control	3
reported worldwide	3
highly pathogenic	3
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seminiferous tubule	3
aii receptor	3
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scientific research	3
aged years	3
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age related	3
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enzyme gene	3
traditional formulation	3
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prospective cohort	3
adverse remodelling	3
using pseudomona	3
signalling pathway	3
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least two	3
clock genes	3
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known facts	3
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pao fio	3
solution reduces	3
lung surfactant	3
antibodies may	3
one possible	3
male covid	3
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viral capsid	3
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ace may	3
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lymphocytic choriomeningitis	3
virus transmission	3
soluble siglec	3
supplemental oxygen	3
promote th	3
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cd cd	3
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avian influenza	3
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creactive protein	3
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induced production	3
pulmonary alveolar	3
complement system	3
dose must	3
inflammatory activity	3
fatal covid	3
current coronavirus	3
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care providers	3
aat response	3
sodium channels	3
vascular breach	3
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lowering drugs	3
lung tissues	3
tumour necrosis	3
lung lesion	3
grade fever	3
specific igg	3
reported cases	3
sound biochemical	3
life cycle	3
sports medicine	3
preventive measure	3
infection ranges	3
antiinflammatory effects	3
vitro study	3
clinically available	3
sulfur dioxide	3
human umbilical	3
improving lung	3
excellent safety	3
oxidant amplification	3
induced myopathy	3
cresyl sulfate	3
available evidence	3
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medical conditions	3
inpatient pregnant	3
higher numbers	3
species complex	3
photodynamic therapy	3
second messenger	3
increases expression	3
yellow fever	3
strongly correlated	3
might result	3
cancer immunotherapy	3
three minutes	3
pg inhibits	3
causal agents	3
application form	3
bl mice	3
chinese center	3
warmer weather	3
capillary leak	3
also pay	3
journal pertain	3
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i herein	3
reduce inflammation	3
ion channel	3
leukocyte recruitment	3
spread across	3
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stat pathway	3
infection covid	3
large scale	3
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like symptoms	3
nih lays	3
mers epidemic	3
carry oxygen	3
potent inhibitor	3
viral conjunctivitis	3
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emerging infection	3
partially responsible	3
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definitive version	3
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primary care	3
stage disease	3
high rate	3
preliminary report	3
via bradykinin	3
primary cultures	3
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lymphocyte proliferation	3
southern italy	3
risk stratification	3
za zhi	3
diminish pulmonary	3
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protected volume	3
microbes infect	3
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lacking amount	3
colleagues reported	3
version will	3
earth pneumoconiosis	3
cover page	3
actin filaments	3
aecii cells	3
previously reported	3
larger droplets	3
support choices	3
old male	3
pm exposure	3
therapeutic regimen	3
clinical implications	3
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medical teams	3
patient care	3
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male germ	3
specific effects	3
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dr low	3
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protein fragments	3
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type iii	3
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important hypothesis	3
ventilatory support	3
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th phenotype	3
microbiome derived	3
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ace based	3
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induced acute	3
radon measurements	3
i interferonopathies	3
foam cells	3
thrombus formation	3
hold potential	3
metabolic rate	3
phosphodiesterase inhibitor	3
inflammatory factors	3
adhesion molecule	3
null women	3
valid hypothesis	3
cd cell	3
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rat liver	3
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essential compounds	3
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dose vka	3
inhibit viral	3
repurpose existing	3
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oral application	3
depleted state	3
factor va	3
hyaline membranes	3
infected person	3
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via molecular	3
national natural	3
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will allow	3
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patients showed	3
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cloak ps	3
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rat stomachs	3
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type diabetics	3
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modern inhalation	3
proteinase inhibitor	3
conditions associated	3
chloramine inhibits	3
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essential component	3
adam also	3
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signaling cascade	3
radon concentration	3
activated factor	3
secondary antibody	3
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errors may	3
cytokinic storm	3
potential usage	3
direct endothelial	3
pseudomonas aeruginosa	3
multifunctional protein	3
drug induced	3
advanced age	3
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nucleic acid	3
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dd genotype	3
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new viral	3
monocytes macrophages	3
monocytic mdsc	3
novel coronaviruses	3
different studies	3
ps cells	3
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inflammatory mediator	3
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receptor cd	3
easily available	3
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long structural	3
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two groups	3
bph treatment	3
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mediated cytokine	3
enzyme inhibition	3
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protein molecule	3
fluidodynamical resistance	3
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care professionals	3
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inflammatory disease	3
conditions described	3
severe pneumonia	3
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significant protection	3
serum vitamin	3
rapidly spreading	3
wakeup call	3
pituitary lymphatic	3
therapeutic application	3
abnormal renal	3
genetic analysis	3
double ring	3
will lead	3
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lower risk	3
containing receptors	3
resistant staphylococcus	3
may serve	3
oral administration	3
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protein encoded	3
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age distribution	3
organ pathology	3
symptomatic relief	3
treatment strategies	3
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glass slide	3
prothrombotic cascade	3
renal dysfunction	3
molecular biology	3
reducing sars	3
patients died	3
regulated androgen	3
inflammatory pathways	3
mast cells	3
airborne particles	3
blood circulation	3
infect dis	3
elderly age	3
studies suggest	3
disrupted activation	3
hypothesis provides	3
respiratory capacity	3
observed following	3
particularly relevant	3
inflammatory monocyte	3
molecular weight	3
cancer cells	3
wuhan city	3
ace imbalance	3
relevant characteristics	3
mechanism underlying	3
pathogenic human	3
surfactant activity	3
ace gene	3
human exposure	3
neutrophil granulocytes	3
response epidemiology	3
moderate level	3
limiting effects	3
gastric mucosal	3
inhibit tmprss	3
studies also	3
saturated phosphatidylcholine	3
clinical practice	3
patients diagnosed	3
skin inflammation	3
antagonist licensed	3
specific funding	3
circulating angiotensin	3
turn activate	3
possible association	3
cause progression	3
coronavirus entry	3
reduces times	3
target drug	3
even better	3
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infections may	3
symptomatic infection	3
pseudomona aeruginosa	3
excessive immune	3
potential benefits	3
redox potential	3
study clinical	3
literature suggests	3
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system enter	3
novel hypothesis	3
related infections	3
peripheral lymphocyte	3
aerosol transmission	3
system cells	3
chinese medicine	3
coronavirus infected	3
fibroblast proliferation	3
ras status	3
potential vaccines	3
cellular protease	3
nucleic acids	3
hla types	3
factor ix	3
acid co	3
spike receptor	3
different respiratory	3
pathways involved	3
consciously check	3
associated pneumonia	3
please note	3
using clinical	3
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devastating infection	3
basic diseases	3
inner leaflets	3
disease spectrum	3
independent risk	3
colostrum maf	3
angiotensin peptides	3
image analysis	3
trials investigating	3
high bioavailability	3
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neuroblastoma cells	3
biological action	3
disease outcome	3
cytokine responses	3
epithelial barrier	3
coronavirus family	3
peroxisome proliferatoractivated	3
remains unclear	3
microvascular injury	3
high frequency	3
might suppress	3
com locate	3
i hypothesized	3
three chinese	3
work proposes	3
may bind	3
virological studies	3
nutritional support	3
microvascular endothelial	3
poor outcome	3
cell counts	3
high potential	3
lung edema	3
actively kept	3
pilot study	3
molecule may	3
atmospheric particles	3
montelukast molecule	3
bone homeostasis	3
different viruses	3
oxidative species	3
exact underlying	3
human health	3
binding pocket	3
lungs will	3
human subjects	3
chest ct	3
basigin cd	3
found online	3
lung alveolar	3
vein endothelial	3
prothrombinase complex	3
derived toxins	3
fully understood	3
relative ace	3
using ptx	3
production via	3
multiple associated	3
vascular pathology	3
ps exposure	3
atpase oxidant	3
immune exhaustion	3
rheum palmatum	3
administered orally	3
deficiency leads	3
tissue regeneration	3
studies investigating	3
gastrointestinal symptoms	3
surface expression	3
terminal glycosylation	3
cardiogenic pulmonary	3
tanning products	3
association study	3
testicular leydig	3
infection control	3
also due	3
reduce mortality	3
years ago	3
significantly lower	3
wuhan province	3
renal disease	3
increased tissue	3
dysfunctional bridge	3
selective review	3
including several	3
virus infectivity	3
current global	3
cardiac pathology	3
considerations suggest	3
human defensin	3
significant attention	3
defa gene	3
system inhibitors	3
vessel exposure	3
hypothesis buried	3
low personal	3
surfactant phospholipids	3
global threat	3
global spread	3
absolute number	3
altitude areas	3
future treatment	3
brain barrier	3
novel sars	3
diminish reactive	3
factor related	3
acetylcysteine treatment	3
allele may	3
potential utility	3
cc allele	3
cytokine profile	3
cultured cells	3
genomewide association	3
asymptomatic stage	3
early identification	3
sars outbreak	3
umbilical vein	3
ground state	3
positive effect	3
significant association	3
patients receiving	3
overactive immune	3
multiple organs	3
enhanced thrombogenicity	3
ps molecules	3
interferon gamma	3
therapeutic implications	3
severe side	3
innate defense	3
disrupted hpa	3
cytokine generation	3
situ evidence	3
natural compounds	3
profound loss	3
active volcanoes	3
urgent need	3
directly related	3
larger particles	3
widely used	3
intracerebral lymphatic	3
hubei province	3
adenosine triphosphate	3
lethal cytokine	3
streptococcus pneumoniae	3
following infection	3
negative conversion	3
initial infection	3
clinical management	3
innate molecule	3
locate mehy	3
hypothesis also	3
erythropoietin resistance	3
infectious respiratory	3
intracranial infections	3
analysis sars	3
wt mice	3
final manuscript	3
respiratory collapse	3
hydroxychloroquine sulfate	3
human peripheral	3
rna interference	3
therapy may	3
severe coronavirus	3
observed using	3
infections caused	3
strong interferon	3
drug clearance	3
vivo experiments	3
cause severe	3
health system	3
deletion polymorphism	3
causative agent	3
bal fluids	3
type diabetic	3
immune evasion	3
help manage	3
oxygen flow	3
mortality following	3
factor activity	3
repurposing strategy	3
storm associated	3
wuhan clinical	3
often associated	3
cancer progression	3
also present	3
sickle cell	3
typical acute	3
virus display	3
hospital mortality	3
critical event	3
confers significant	3
administering nih	3
affect male	3
respiratory epithelial	3
pdf file	3
phospholipid bilayers	3
induced cytokine	3
prone positioning	3
environmental factors	3
dead people	3
harmful effects	3
ards associated	3
phase response	3
hypothesis may	3
healthy individuals	3
experimental model	3
hepatoma cells	3
therapeutic strategy	3
cells within	3
hyperinflammatory stage	3
immune effects	3
strong differences	3
human cell	3
connective tissue	3
biologically active	3
virtual screening	3
paper discusses	3
toxic side	3
drag force	3
pragmatic solution	3
inhibit neutrophil	3
stage covid	3
lining fluid	3
undergo additional	3
specific cd	3
fecal calprotectin	3
inflammatory injury	3
confirmed covid	3
therapeutic targets	3
beetroot juice	3
early anticoagulation	3
soluble form	3
endothelial protein	3
clinical efficacy	3
plasma vitamin	3
inflammatory states	3
potentially induce	3
liver cell	3
activity seen	3
cellular redox	3
nucleocapsid protein	3
nasal spray	3
uk patients	3
also shown	3
room temperature	3
three cases	3
multiple factors	3
major cause	3
potentially enhance	3
human intestinal	3
serum cholesterol	3
extrapulmonary manifestations	3
control study	3
hybrid lipids	3
dimer levels	3
envelope glycoproteins	3
dose required	3
mesenteric lymphatics	3
viruses like	3
front line	3
neutrophil adhesion	3
especially respiratory	3
pathophysiologic mechanisms	3
genome replication	3
acute kidney	3
like protease	3
lower absorption	3
pulmonary perfusion	3
clinical significance	3
current understanding	3
falciparum malaria	3
supplementary data	3
ace function	3
important contribution	3
already approved	3
variable severity	3
increase endothelial	3
least seven	3
times greater	3
plant virus	3
determine whether	3
tissue repair	3
suppress overactive	3
adrenal axis	3
markedly reduced	3
genomic characterization	3
different types	3
side effect	3
study characteristics	3
national institutes	3
cell type	3
like endothelial	3
pulmonary compliance	3
smoking might	3
protein mediates	3
different viral	3
whole blood	3
asymptomatic patients	3
pathogen causing	3
final form	3
viral envelope	3
different mechanisms	3
pulmonary ossification	3
cascade generated	3
three active	3
patients often	3
accelerated hydrogen	3
published studies	3
hereby declare	3
microthrombi formation	3
barr virus	3
naive cd	3
immune dysfunction	3
associate sars	3
peaked epidemic	3
human blood	3
legal disclaimers	3
disease susceptibility	3
factor alpha	3
liver involvement	3
inflammatory angiotensin	3
deadly virus	3
patients affected	3
existent depleted	3
treating physicians	3
nonsynonymous mutations	3
inflammatory conditions	3
th response	3
ibuprofen necessary	3
channel activity	3
great relevant	3
cardiovascular system	3
dengue virus	3
regional topography	3
normal hepatic	3
placebo controlled	3
multiple sclerosis	3
enzyme protects	3
coronavirus attachment	3
antiviral responses	3
several mechanisms	3
reduced local	3
leukocyte function	3
osteoclast differentiation	3
longitudinal characteristics	3
subclinical nutritional	3
significantly associated	3
molecular level	3
includes coronavirus	3
neonatal outcomes	3
low molecular	3
possible mechanisms	3
potential mechanisms	3
prevention strategies	3
advanced covid	3
food may	3
drainage differences	3
multiorgan damage	3
mouth disease	3
high ace	3
ibuprofen demonstrated	3
injury leading	3
inhaled hydroxychloroquine	3
drug design	3
causing respiratory	3
mathematical model	3
therapeutic interventions	3
developing severe	3
antiviral agents	3
known whether	3
lung imaging	3
genes may	3
cryptococcus gattii	3
glycation products	3
zinc intake	3
results suggest	3