trigram

This is a table of type trigram and their frequencies. Use it to search & browse the list to learn more about your study carrel.

trigram	frequency
as well as	1070
severe acute respiratory	1055
acute respiratory syndrome	1040
respiratory syndrome coronavirus	895
of the sars	862
the number of	858
the presence of	750
based on the	599
in order to	588
in this study	560
due to the	504
we found that	500
structure of the	461
was used to	445
of the virus	433
one of the	425
analysis of the	404
cd t cells	393
the spike protein	371
in addition to	355
compared to the	350
the expression of	346
the s protein	341
the development of	339
of the s	320
at room temperature	304
the use of	304
according to the	303
the role of	300
the effect of	299
a total of	284
in patients with	280
to determine the	274
the absence of	271
c t s	269
shown in figure	263
in the presence	261
each of the	256
in terms of	253
of severe acute	252
of the viral	250
was performed using	248
as shown in	246
can be used	245
ace and tmprss	243
of the spike	239
was added to	234
s and s	232
associated with the	229
consistent with the	229
of the human	227
be used to	225
vero e cells	223
it has been	223
found to be	221
with respect to	217
extended data fig	216
a new coronavirus	215
well as the	212
east respiratory syndrome	211
the novel coronavirus	210
been shown to	210
of novel coronavirus	210
in response to	208
middle east respiratory	208
the treatment of	207
a novel coronavirus	207
the case of	207
the impact of	205
the context of	202
in the absence	201
in the same	201
the effects of	200
most of the	200
in the case	200
cells in the	200
the majority of	199
patients with covid	198
in the context	195
was used for	193
on the other	192
the structure of	192
that can be	192
the severe acute	191
part of the	190
a number of	188
in the lungs	188
protein of sars	186
such as the	184
of the protein	183
in the sars	182
associated with a	182
were used to	180
as previously described	179
the fact that	179
a set of	178
changes in the	178
in the human	177
are shown in	177
added to the	176
there is a	175
in the s	174
has been shown	174
the binding of	171
similar to the	170
the other hand	170
observed in the	167
n s p	167
the s subunit	167
a and b	167
cov and sars	166
the results of	166
as a result	165
the host cell	164
of the covid	163
is consistent with	162
present in the	162
used in the	161
a variety of	160
receptor binding domain	160
in the lung	160
end of the	158
the importance of	158
influenza a virus	157
is associated with	157
as compared to	155
we used the	154
binding to the	153
the detection of	152
the level of	152
found that the	152
for min at	152
were able to	152
t cells in	151
the analysis of	151
the sars coronavirus	150
were used for	150
used as a	149
total number of	149
was carried out	149
we did not	149
large number of	149
we show that	149
to the sars	148
for the treatment	148
expression of ace	147
crystal structure of	147
in contrast to	147
shown in fig	146
the ace receptor	144
the present study	143
infected with sars	143
between the two	142
of the novel	142
was used as	142
results suggest that	141
the addition of	141
a range of	141
it is possible	140
role in the	140
suggest that the	140
showed that the	140
to investigate the	140
coronavirus spike protein	140
the emergence of	140
of the two	140
involved in the	139
we observed that	139
the ability of	139
the end of	138
related to the	137
to assess the	137
at the same	136
the active site	136
the ability to	136
at least one	136
novel coronavirus from	136
the d g	135
to identify the	134
was found to	134
the formation of	133
analysis was performed	133
the surface of	132
region of the	132
found in the	132
the s s	132
of a novel	132
structural basis for	132
of the same	131
suggests that the	131
the evolution of	131
the distribution of	130
the viral genome	130
as described above	130
detection of sars	130
likely to be	129
em structure of	129
insights into the	129
of the rbd	129
expression of the	129
in complex with	128
the production of	128
with a new	128
the performance of	128
were found to	127
is shown in	127
that of the	127
some of the	127
in this work	126
type i interferon	126
of coronavirus disease	125
the receptor binding	125
in which the	125
the amount of	125
were obtained from	124
has been reported	123
to be a	123
was observed in	123
of sars coronavirus	123
to understand the	123
the total number	123
were performed using	123
all of the	123
is required for	123
we used a	122
the amino acid	122
mutations in the	122
acute respiratory distress	122
to evaluate the	122
the authors declare	121
for the sars	121
the identification of	121
in agreement with	121
respiratory distress syndrome	121
used for the	121
hepatitis c virus	120
a subset of	120
obtained from the	120
figure s a	120
the lack of	120
relative to the	119
spike protein of	119
cd t cell	119
of the genome	118
to be the	118
shown to be	118
probable bat origin	118
were treated with	117
responsible for the	117
activation of the	117
results indicate that	117
data not shown	117
the need for	116
regions of the	115
a pneumonia outbreak	115
thermo fisher scientific	115
of the three	115
multiple sequence alignment	115
world health organization	115
new coronavirus of	114
pneumonia outbreak associated	114
coronavirus of probable	114
outbreak associated with	114
of probable bat	114
were carried out	114
disease in china	113
of the most	113
supported by the	113
an increase in	113
understanding of the	112
there is no	112
to determine whether	112
d g mutation	112
coronavirus associated with	112
differences in the	112
contribute to the	111
for each of	111
in line with	111
high levels of	111
were added to	110
on ace and	110
to that of	110
the mechanism of	110
response to sars	109
a result of	109
is blocked by	109
need to be	109
used in this	109
a series of	109
the cells were	108
depends on ace	108
t t t	108
as described in	108
cell entry depends	108
in this case	108
entry depends on	108
a large number	107
antigenicity of the	107
in figure a	107
there was a	106
tmprss and is	106
blocked by a	106
the time of	106
the proportion of	106
the interaction between	106
and tmprss and	106
treatment of covid	106
are associated with	106
in the first	106
there was no	105
a clinically proven	105
to reduce the	105
characterization of the	105
by a clinically	105
and is blocked	105
referred to as	105
from patients with	105
respect to the	105
and in the	104
to the ace	104
due to its	104
show that the	104
the course of	104
have been reported	103
clinically proven protease	103
detected in the	103
corresponding to the	103
respiratory disease in	103
the frequency of	102
the crystal structure	102
t a t	102
than that of	102
the pathogenesis of	102
of the first	102
derived from the	102
structure of sars	101
in the prefusion	101
is essential for	101
resulted in a	101
proven protease inhibitor	101
included in the	100
revealed that the	100
performed using the	99
origin of sars	99
figure s b	99
the percentage of	99
it is not	99
was supported by	99
based on a	98
this suggests that	98
with the same	98
are known to	98
we compared the	97
patients with severe	97
dependent rna polymerase	97
the prefusion conformation	97
structural and functional	97
located in the	97
bound to the	97
have shown that	97
cov and mers	97
the rate of	96
and antigenicity of	96
the range of	95
and characterization of	95
in the present	95
transmission of sars	95
differentially expressed genes	95
caused by the	94
model of the	94
were incubated with	94
in severe covid	94
patients infected with	94
that could be	94
it can be	94
nsp and nsp	94
depending on the	94
to have a	94
we performed a	93
be found in	93
on the surface	93
amino acid residues	93
in comparison to	93
known to be	93
we find that	93
cd and cd	93
which is a	92
amino acid sequence	92
we observed a	92
addition to the	92
the s domain	92
more likely to	92
a systematic review	92
it is also	92
which can be	92
basis for the	92
for the first	92
be able to	92
were infected with	91
t cell responses	91
a role in	91
a function of	91
followed by a	91
of viral rna	91
is able to	90
human respiratory disease	90
the activity of	90
associated with human	90
binding of the	90
were used as	90
can be found	90
is important to	90
ace expression in	90
development of a	89
a combination of	89
function of the	89
for minutes at	89
with pneumonia in	89
clinical characteristics of	89
in combination with	89
these results suggest	89
is known to	89
are consistent with	89
with novel coronavirus	89
we were able	89
is responsible for	89
t cells were	89
predicted to be	89
angiotensin converting enzyme	88
the university of	88
and incubated for	88
the generation of	88
suggesting that the	88
is based on	88
but not in	88
of the rna	88
of the disease	88
the same time	87
the spread of	87
of the n	87
new coronavirus associated	87
spike in the	87
of the host	87
for the development	87
as described previously	87
innate immune response	87
is possible that	87
novel coronavirus in	87
with human respiratory	87
in table s	87
when compared to	86
authors declare no	86
to predict the	86
the rbd of	86
from the same	86
bind to the	86
b and c	86
the size of	86
to the human	85
of ace in	85
evolution of the	85
activity of the	85
of this study	85
molecular dynamics simulations	85
any of the	85
was performed on	85
at the time	84
an important role	84
of the coronavirus	84
to estimate the	84
limit of detection	84
in the spike	84
responses to sars	84
to the s	84
members of the	84
proteins of sars	84
more than one	84
for the detection	84
use of the	84
figure a and	83
wang et al	83
is supported by	83
structures of the	83
surface of the	83
increase in the	83
to the same	82
to study the	82
would like to	82
data suggest that	82
it is important	82
the rest of	82
and bat cov	82
has also been	82
we hypothesized that	82
has not been	82
is one of	82
human immunodeficiency virus	82
can also be	82
a wide range	82
ncov spike in	82
of the data	81
wide range of	81
in the viral	81
the activation of	81
in the brain	80
the united states	80
shows that the	80
the immune response	80
of type i	80
the possibility of	80
analysis of sars	80
was applied to	80
at the s	80
in this paper	80
were detected in	80
distribution of the	79
because of the	79
in vitro and	79
be due to	79
and evolution of	79
effect of the	79
allowed us to	79
the length of	79
response to the	79
of the ace	79
to this end	78
important role in	78
sars and mers	78
in the current	78
appear to be	78
no competing interests	78
be used for	78
a recent study	78
the levels of	78
difference between the	78
in at least	77
the set of	77
the potential to	77
to explore the	77
the basis of	77
in our study	77
identified in the	77
the dynamics of	76
as a function	76
due to a	76
properties of the	76
c and d	76
the possibility that	76
in a single	76
the innate immune	76
the risk of	76
many of the	76
the human genome	76
g t t	76
domain of the	76
we sought to	76
indicate that the	75
the function of	75
and stored at	75
orf a and	75
been reported to	75
of patients infected	75
are able to	75
airway epithelial cells	75
that have been	75
using the same	75
in the future	75
to the rbd	75
we analyzed the	75
final concentration of	75
of patients with	74
of the sequences	74
and it is	74
the ratio of	74
nature of the	74
and in vivo	74
in rhesus macaques	74
the copyright holder	74
was performed with	74
clinical features of	74
type i ifn	74
of the total	74
added to each	74
the existence of	74
to interact with	74
li et al	74
of ace and	73
and can be	73
for this preprint	73
which was not	73
holder for this	73
with the highest	73
receptor recognition by	73
closely related to	73
rest of the	73
this study was	73
in accordance with	73
evolution of sars	73
as in the	73
copyright holder for	73
for the analysis	72
antiviral activity of	72
with the exception	72
the beginning of	72
to the host	72
was determined by	72
a concentration of	72
of cd t	72
comparison of the	72
sequence of the	72
the loss of	72
in vero cells	72
side of the	72
carried out using	72
residues in the	72
as a potential	72
could be used	72
due to their	72
none of the	72
hospitalized patients with	71
t t a	71
size of the	71
respiratory syncytial virus	71
the influence of	71
the immune system	71
version of the	71
together with the	71
length of the	71
the regulation of	71
with severe acute	71
t g t	71
out of the	71
their ability to	71
patients with pneumonia	71
immune response to	71
could not be	71
stability of the	71
for h at	71
structural basis of	71
there is an	70
we note that	70
of amino acid	70
parts of the	70
to test the	70
reported to be	70
to compare the	70
in the rbd	70
the stability of	70
the supernatant was	70
is critical for	70
the severity of	70
and incubated at	70
were performed in	70
with or without	69
the efficacy of	69
is used to	69
have been shown	69
sequences of the	69
is involved in	69
and analysis of	69
the probability of	69
of neutralizing antibodies	69
the control of	69
this work was	69
each of these	69
is likely to	69
results show that	69
be used as	68
dorsal accessory calyx	68
like to thank	68
may be a	68
mechanism of action	68
was set to	68
the current study	68
appears to be	68
we demonstrate that	68
cell rna sequencing	68
s protein of	68
cells were treated	68
be involved in	68
be explained by	68
the relationship between	68
syndrome coronavirus spike	67
memory cd t	67
a review of	67
in figure b	67
expression in the	67
cells of the	67
defined as the	67
results showed that	67
around the world	67
of the cell	67
sars coronavirus spike	67
of a single	67
results of the	67
the limit of	67
at a concentration	67
can be seen	67
indicating that the	67
the release of	67
the potential for	67
interact with the	67
the study of	67
protein data bank	66
described in the	66
these results indicate	66
at the end	66
cells were incubated	66
a list of	66
into host cells	66
pneumonia in china	66
our understanding of	66
presence of the	66
of the samples	66
in vero e	66
was performed in	66
is that the	66
serve as a	66
this is the	66
the concentration of	66
of s protein	65
cell types in	65
close to the	65
functional receptor for	65
to better understand	65
that it is	65
can lead to	65
suggested that the	65
considered to be	65
gene expression in	65
different types of	65
in the following	65
was associated with	65
expressed in the	65
the design of	65
shown in table	65
the extent of	64
identification of a	64
the dorsal accessory	64
and cd t	64
coronavirus from patients	64
the author funder	64
interactions between the	64
role of the	64
agreement with the	64
genes involved in	64
to calculate the	64
amino acid sequences	64
transcranial magnetic stimulation	64
mapped to the	64
were observed in	64
is the author	64
and the number	64
presence of a	64
the degree of	64
p and p	64
of the severe	63
at least two	63
are likely to	63
the combination of	63
was shown to	63
was performed by	63
the form of	63
the respiratory tract	63
the onset of	63
effect on the	63
resulting in a	63
approved by the	63
the discovery of	63
single cell rna	63
is the most	63
interactions with the	63
to examine the	63
the most common	63
based on their	63
antibodies against sars	63
in relation to	63
were collected from	62
it should be	62
the viral spike	62
effects of the	62
specific cd t	62
cells were washed	62
of the full	62
change in the	62
the hypothesis that	62
the exception of	62
the center of	62
we calculated the	62
highly expressed in	62
zhou et al	62
in the second	62
was able to	62
were found in	62
for detection of	62
the lungs of	62
the origin of	62
may not be	62
it is a	62
mouse hepatitis virus	62
used as the	61
h n influenza	61
position of the	61
to confirm the	61
are involved in	61
the nature of	61
to determine if	61
features of patients	61
s s cleavage	61
the recognition of	61
mediated by the	61
were determined by	61
is mediated by	61
determined by the	61
of t cell	61
to increase the	61
declare no competing	61
vitro and in	61
were generated using	61
the plasma membrane	61
s protein is	61
is due to	61
state of the	61
spike protein and	61
to improve the	61
similar to that	61
inhibition of the	60
that of sars	60
prior to the	60
binds to the	60
characterization of a	60
to the reference	60
remains to be	60
on the same	60
we examined the	60
that the sars	60
to bind to	60
of the complex	60
followed by the	60
components of the	60
a final concentration	60
provided by the	59
the middle east	59
by flow cytometry	59
along with the	59
memory b cells	59
entry into host	59
c t t	59
and receptor binding	59
binding free energy	59
at o c	59
the s and	59
in the form	59
in case of	59
supplementary figure s	59
focused on the	59
removed from the	59
as part of	59
listed in table	59
analysis revealed that	59
portion of the	59
the fraction of	59
the process of	59
majority of the	59
for hours at	59
be associated with	59
it is likely	58
we propose that	58
indicates that the	58
of the immune	58
the interaction of	58
human monoclonal antibody	58
lead to a	58
of the other	58
a panel of	58
by severe acute	58
were incubated at	58
to analyze the	58
compared to other	58
the value of	58
and found that	58
we showed that	58
dynamics of the	58
with and without	58
study of the	58
fetal bovine serum	58
the virus to	58
with a high	58
which may be	58
materials and methods	58
the world health	58
hek t cells	58
proteins in the	58
the result of	58
room temperature for	58
the spike glycoprotein	58
a bp kenyon	58
was detected in	58
sequences in the	58
there are no	58
by using the	58
which has been	58
viral replication and	57
is defined as	57
was obtained from	57
is the first	57
of infected cells	57
as measured by	57
that may be	57
note that the	57
away from the	57
for further analysis	57
the first time	57
were subjected to	57
corresponds to the	57
on the basis	57
domain bound to	57
compared with the	57
virus infection in	57
differences between the	57
of influenza a	57
of the study	57
of the proteins	57
of severe covid	57
well as in	57
infected with novel	57
caused by sars	57
that there is	56
neutralizing antibodies against	56
interaction with the	56
the human ace	56
of the system	56
were identified in	56
spread of sars	56
the induction of	56
features of the	56
may contribute to	56
the coronavirus disease	56
which is the	56
the n protein	56
to ensure that	56
calculated using the	56
infection with sars	56
receptor for sars	56
were purchased from	56
we use the	56
the genome of	56
the prediction of	56
cells were infected	56
we do not	56
human airway epithelial	56
of which are	56
the binding affinity	56
to our knowledge	56
bp kenyon cells	56
a lack of	56
activity against sars	56
human monoclonal antibodies	56
performance of the	55
in the treatment	55
aligned to the	55
performed using a	55
a t a	55
inhibition of sars	55
and orf b	55
in the study	55
with the sars	55
the accuracy of	55
in the population	55
based on our	55
were selected for	55
has been used	55
seems to be	55
acute lung injury	55
spread of the	55
of the d	55
to be more	55
play a role	55
be noted that	55
impact on the	55
was performed to	55
to account for	55
in the genome	55
is made available	55
and epidemiology of	55
conflict of interest	55
an urgent need	55
binding affinity to	55
to the virus	55
of the pandemic	55
of ace expression	54
in all three	54
applied to the	54
that has been	54
cells were seeded	54
made available under	54
that in the	54
and the s	54
required for the	54
of all the	54
is similar to	54
epidemiology of novel	54
demonstrated that the	54
the virus in	54
we investigated the	54
the quality of	54
likely due to	54
are listed in	54
of the receptor	54
differential gene expression	54
observed that the	54
implications for virus	54
immune response in	54
cells were fixed	54
a a t	54
needs to be	54
open reading frame	54
context of the	54
available under a	54
to obtain the	54
in infected cells	54
used to identify	54
in the last	54
cases of covid	54
is an important	53
for each sample	53
of the mean	53
genomic characterisation and	53
component of the	53
the synthesis of	53
these data suggest	53
is expected to	53
to address this	53
a and s	53
the cell surface	53
allows us to	53
that do not	53
the abundance of	53
in both the	53
have not been	53
coronavirus in wuhan	53
data indicate that	53
emergence of sars	53
to obtain a	53
zhang et al	53
mutation in the	53
consistent with a	53
in the range	53
characterisation and epidemiology	53
gene set enrichment	53
the wild type	53
we tested the	53
to the other	53
the replication of	53
the potential of	53
for binding to	53
of the nsp	53
depends on the	53
of hospitalized patients	53
human sars cov	53
higher than the	52
genes in the	52
a t t	52
of spike protein	52
have also been	52
the reference genome	52
a measure of	52
protein in the	52
and function of	52
immune responses to	52
the difference between	52
were incubated for	52
c g t	52
of gene expression	52
with an average	52
a and orf	52
in the field	52
experiments were performed	52
infection of human	52
of the model	52
that they are	52
the plate was	52
the virus and	52
at the beginning	52
the virus was	52
interaction between the	52
the sensitivity of	52
of the main	52
in the number	52
gene expression data	52
value of the	52
higher levels of	52
protein is a	52
viral spike protein	52
in cd t	52
high level of	52
on vero e	52
data from the	52
for the recognition	52
binding domain bound	51
were analyzed by	51
type i and	51
is expressed in	51
was measured by	51
for hour at	51
similar to those	51
with a single	51
under a the	51
t cd c	51
also known as	51
site of the	51
a the copyright	51
origins and receptor	51
for virus origins	51
during the covid	51
to each well	51
of the current	51
t c t	51
cells were then	51
the rbd and	51
with coronavirus disease	51
virus origins and	51
impact of the	51
in the two	51
expression levels of	51
in the cell	51
a c t	51
results in a	51
structure of a	50
half of the	50
cell types and	50
dependent on the	50
host immune response	50
in this region	50
lung epithelial cells	50
is characterized by	50
of the four	50
by the viral	50
polymerase chain reaction	50
of orf a	50
t cell epitopes	50
we report the	50
the other two	50
we evaluated the	50
and has been	50
is likely that	50
in figure s	50
walls et al	50
used to generate	50
values of the	50
were used in	50
to characterize the	50
n and n	50
did not show	50
in the united	50
length human ace	49
shown in the	49
analysis based on	49
entry into the	49
to test this	49
of the sequence	49
binding to ace	49
the inhibition of	49
in the host	49
no effect on	49
in clinical trials	49
set enrichment analysis	49
virus in the	49
anp high pmn	49
for at least	49
to detect the	49
s cleavage site	49
in the respiratory	49
of the infection	49
in the early	49
susceptible to sars	49
have been developed	49
spike protein is	49
sequences of sars	49
were downloaded from	49
wrapp et al	49
and of the	49
the accumulation of	49
our results suggest	49
fact that the	49
difference in the	49
a comparison of	49
in the past	49
of a protein	48
to measure the	48
based on these	48
work was supported	48
s p g	48
of dot l	48
according to their	48
to form a	48
with the s	48
composition of the	48
with that of	48
contrast to the	48
wu et al	48
an overview of	48
to the viral	48
were excluded from	48
for the s	48
to those of	48
consistent with previous	48
for all the	48
the causative agent	48
the interaction with	48
in the protein	48
genes associated with	48
belongs to the	48
memory t cells	48
chen et al	48
coronavirus spike glycoprotein	48
the entry of	48
receptor for the	48
studies have shown	48
a group of	48
in the pathogenesis	48
to be used	48
the availability of	48
by the sars	48
the viral rna	48
that there are	48
were stained with	48
a consequence of	48
were calculated using	48
representation of the	48
well as a	48
interacts with the	48
into the host	48
and table s	47
no significant differences	47
did not observe	47
of the original	47
the difference in	47
recognition of sars	47
in the nasal	47
analyses were performed	47
it may be	47
binding domain of	47
in the cytoplasm	47
the occurrence of	47
at the level	47
in the low	47
to each other	47
the significance of	47
as a control	47
to validate the	47
in figure c	47
d and e	47
an in vitro	47
was removed and	47
from a single	47
an average of	47
the cytokine storm	47
of the cells	47
a model of	47
of viral replication	47
coronavirus spike proteins	47
new england biolabs	47
beginning of the	47
was found in	47
orders of magnitude	47
the magnitude of	47
cleavage of the	47
t t g	47
of viral proteins	47
so that the	47
of influenza virus	47
differential expression analysis	47
we developed a	47
the most potent	47
is not a	47
is composed of	47
the efficiency of	47
leading to a	47
leading to the	47
rbd of sars	47
of the world	46
the observation that	46
neutralization of sars	46
found to have	46
by the novel	46
t cells and	46
a study of	46
hoffmann et al	46
host cell receptor	46
studies of the	46
the phylogenetic tree	46
significant increase in	46
in the analysis	46
except for the	46
in this context	46
as it is	46
we identified a	46
more than of	46
for a given	46
a negative control	46
structure and function	46
figure s c	46
are shown as	46
in the n	46
figure c and	46
could be a	46
we conclude that	46
was calculated using	46
on the first	46
rna secondary structure	46
transferred to a	46
b cell epitopes	46
and that the	46
sharing all influenza	46
the in vitro	46
those of the	46
basis of sars	46
been used to	46
samples were collected	46
the origin and	46
of infectious diseases	46
were analyzed using	46
alveolar epithelial cells	46
in the literature	46
we focused on	46
to provide a	46
total rna was	45
the involvement of	45
be applied to	45
its ability to	45
associated with severe	45
peripheral blood mononuclear	45
with at least	45
has been suggested	45
evaluation of the	45
with more than	45
in the development	45
the samples were	45
high expression of	45
the utility of	45
morbidity and mortality	45
in human airway	45
studies of sars	45
within the same	45
do not have	45
spike glycoprotein of	45
of middle east	45
the need to	45
mhc class i	45
as a reference	45
to generate the	45
a positive control	45
the same as	45
t cell receptor	45
conformation of the	45
amino acid substitutions	45
extended data figure	45
this is in	45
and development of	45
is a key	45
cell responses to	45
on the sars	45
are required for	45
of mutations in	45
serial dilutions of	45
fraction of the	45
we have previously	45
the mice were	45
this is a	45
in more than	45
central nervous system	45
the viral replication	45
were collected at	45
of the target	45
rna was extracted	45
detection of novel	45
one or more	45
as determined by	45
may also be	45
figure b and	45
in the covid	45
of the antibody	45
rbd and the	44
comparative analysis of	44
to human ace	44
for the presence	44
leads to a	44
are predicted to	44
we also found	44
s p c	44
a highly conserved	44
are present in	44
that the s	44
is an urgent	44
this is consistent	44
g c t	44
the protein data	44
is in the	44
in the olfactory	44
risk factors for	44
we have used	44
and subjected to	44
was observed for	44
have been identified	44
all of these	44
all influenza data	44
epithelial cells and	44
we determined the	44
indicated that the	44
a functional receptor	44
results demonstrate that	44
than in the	44
error bars represent	44
an analysis of	44
was performed as	44
resulted in the	44
we believe that	44
the cost of	44
to generate a	44
this study are	44
were identified as	44
for the covid	44
the contribution of	44
isolated from a	44
and the other	44
have been used	44
are used to	44
a c a	44
t t c	44
to note that	44
antibody responses to	44
higher than that	44
and t cell	44
to quantify the	44
c a t	44
to be an	44
the specificity of	44
immune repertoire classification	44
account for the	44
global initiative on	43
initiative on sharing	43
in some cases	43
g for min	43
and s subunits	43
of the genes	43
a reduction in	43
of these two	43
we have developed	43
with the ace	43
to define the	43
we would like	43
is a functional	43
and orf a	43
is caused by	43
downloaded from the	43
this indicates that	43
the effectiveness of	43
causative agent of	43
this study were	43
is important for	43
before and after	43
in human cells	43
the distance between	43
the prevalence of	43
in the sample	43
of s and	43
with severe covid	43
performed on the	43
carried out in	43
to a final	43
the human population	43
insight into the	43
the plates were	43
course of the	43
presence or absence	43
better understanding of	43
are needed to	43
a a a	43
a key role	43
the differences in	43
is a major	43
increased expression of	43
expression of genes	43
to the cell	43
to find the	43
did not have	43
s protein and	43
cov spike protein	43
s a and	43
modern hopfield networks	43
it was found	43
extracted from the	43
in the original	43
the reference sequence	43
infectivity of the	43
ability of the	43
for treatment of	43
terms of the	43
are presented as	43
antiviral activity against	43
innate immune responses	43
detection of the	43
harmonic and inharmonic	42
a decrease in	42
of the number	42
that are not	42
replication of sars	42
proximal origin of	42
in the middle	42
standard error of	42
t c g	42
for min and	42
viral entry into	42
viral load in	42
of amino acids	42
may lead to	42
binding site of	42
in all cases	42
these data indicate	42
is thought to	42
pneumonia in wuhan	42
we present a	42
that the virus	42
for the virus	42
lower than the	42
the secondary site	42
the proximal origin	42
binding of sars	42
mechanisms of sars	42
a previous study	42
the position of	42
there were no	42
did not affect	42
the amino acids	42
h n virus	42
were transferred to	42
the current pandemic	42
immunodeficiency virus type	42
rna was isolated	42
figure s d	42
were associated with	42
been shown that	42
has been previously	41
it is worth	41
h n pdm	41
we have also	41
is predicted to	41
of the lung	41
the changes in	41
and s a	41
used to calculate	41
on the viral	41
the current covid	41
and does not	41
the whole genome	41
the order of	41
essential for the	41
blood mononuclear cells	41
on sharing all	41
of h n	41
the first and	41
s subunit of	41
in the supplementary	41
structural studies of	41
of the active	41
a global pandemic	41
binding affinity of	41
specific t cells	41
by using a	41
use of a	41
was isolated from	41
for use in	41
expression level of	41
led to the	41
entry of sars	41
types in the	41
in the virus	41
systematic review and	41
vesicular stomatitis virus	41
the virus is	41
error of the	41
c a a	41
the sequence of	41
determine whether the	41
and figure s	41
structural analysis of	41
of the experiment	41
we speculate that	41
is the number	41
belonging to the	41
are presented in	41
positive and negative	41
of spike glycoprotein	41
the outbreak of	41
sequences from the	40
the sum of	40
that had been	40
available at https	40
innate immune system	40
in the main	40
available in the	40
is necessary to	40
of viral infection	40
web server for	40
it is made	40
human pluripotent stem	40
of coronavirus spike	40
led to a	40
observed for the	40
play an important	40
for the same	40
the host cells	40
d and s	40
the cause of	40
is possible to	40
levels in the	40
belong to the	40
disease control and	40
review of the	40
should be noted	40
mice infected with	40
domain complexed with	40
of these genes	40
c c t	40
glycoprotein of sars	40
but did not	40
the first step	40
be related to	40
correlated with the	40
the start of	40
or absence of	40
and treatment of	40
using the following	40
expected to be	40
the presence or	40
was incubated with	40
explained by the	40
our results indicate	40
in cell culture	40
a t c	40
member of the	40
seen in the	40
with the following	40
authors declare that	40
findings suggest that	40
as indicated by	40
in other words	40
small number of	40
based on this	40
balb c mice	39
to create a	39
in the receptor	39
has the potential	39
two of the	39
proteins of the	39
recognition by sars	39
urgent need for	39
by the addition	39
low levels of	39
of each of	39
has been proposed	39
have been proposed	39
we also observed	39
for this study	39
furin cleavage site	39
are provided in	39
of more than	39
line with the	39
control and prevention	39
of a sars	39
in the data	39
principal component analysis	39
origin of the	39
no conflict of	39
to develop a	39
of ace protein	39
activity in the	39
mouse model of	39
is sufficient to	39
to facilitate the	39
sb and sb	39
secondary structure of	39
of the binding	39
linked to the	39
in the nucleus	39
in the world	39
incubated for min	39
of the mutations	39
sites in the	39
the free energy	39
significant differences in	39
from the first	39
for the two	39
are given in	39
was done using	39
the composition of	39
the ace microbody	39
was extracted from	39
minutes at room	39
information about the	39
of the amino	39
smith et al	39
recognition by the	39
host response to	39
rbd of the	39
appeared to be	39
presence of sars	39
of tcf l	39
known as the	39
quality of the	39
cell entry and	39
the feasibility of	38
protein interaction map	38
better understand the	38
protein of the	38
liu et al	38
at least in	38
the viral envelope	38
free energy of	38
national institutes of	38
levels of the	38
in the regulation	38
are susceptible to	38
d and d	38
hydrogen bonds with	38
in the previous	38
and the resulting	38
the infectivity of	38
with the host	38
of ebola virus	38
and stained with	38
for disease control	38
as opposed to	38
prediction of the	38
s s site	38
its role in	38
that they have	38
were present in	38
was not certified	38
not certified by	38
for both the	38
cells infected with	38
high degree of	38
certified by peer	38
we demonstrated that	38
of s a	38
of the variants	38
olfactory sensory neurons	38
emerging infectious diseases	38
review and meta	38
using human ace	38
model of sars	38
was confirmed by	38
the endoplasmic reticulum	38
decrease in the	38
the s trimer	38
thought to be	38
shown that the	38
it would be	38
used as an	38
basis of receptor	38
each cell type	38
can be applied	38
for viral replication	38
residues of the	38
of at least	38
the strength of	38
c and c	38
with acute respiratory	38
false discovery rate	38
of a given	38
be used in	38
by peer review	38
this version posted	38
novel coronavirus sars	38
different cell types	38
severity of covid	38
the orf ab	38
yang et al	38
to the corresponding	38
which have been	38
view of the	38
the purpose of	38
caused by a	38
male and female	38
of receptor recognition	38
are responsible for	37
of the orf	37
was mixed with	37
ace and the	37
and the human	37
of the corresponding	37
energy of the	37
national center for	37
for vaccine development	37
used to determine	37
supported by a	37
and for the	37
seem to be	37
is present in	37
a pair of	37
was defined as	37
were performed on	37
not yet been	37
are found in	37
demonstrate that the	37
infected by sars	37
the most important	37
entry by using	37
could also be	37
of the innate	37
specificity of the	37
the location of	37
in the reference	37
characteristics of the	37
infection in the	37
and functional basis	37
herpes simplex virus	37
not in the	37
not able to	37
g t c	37
as a consequence	37
presented as mean	37
were aligned to	37
ranging from to	37
the genomes of	37
school health services	37
epitopes in the	37
viral rna was	37
patients with coronavirus	37
a target for	37
were resuspended in	37
to the development	37
of the brain	37
the sequences of	37
which in turn	37
bonds with the	37
functional basis of	37
crystal structures of	37
against the sars	37
the infection of	37
infection of the	37
a better understanding	37
of human sars	37
of the predicted	37
that did not	37
of a large	37
s a a	37
converting enzyme is	37
acts as a	37
viral infection and	37
in the orf	37
of the entire	37
factors such as	37
the selection of	37
open reading frames	37
in the next	37
the choice of	37
of the drug	37
regulation of the	37
variation in the	37
of action of	37
the sample was	37
has been demonstrated	37
authors would like	36
its spike protein	36
to a single	36
and s d	36
as for the	36
in humans and	36
coronavirus from wuhan	36
were exposed to	36
in a dose	36
and the results	36
than of the	36
protein secondary structure	36
effects on the	36
we propose a	36
to be able	36
calculated based on	36
us to identify	36
number of reads	36
outside of the	36
were retrieved from	36
broad range of	36
are based on	36
human and mouse	36
min at room	36
lead to the	36
interacting with the	36
of thousands of	36
assays were performed	36
located at the	36
we assessed the	36
is located in	36
syndrome coronavirus infection	36
resulting in the	36
leads to the	36
different from the	36
is difficult to	36
a role for	36
a tool for	36
in saudi arabia	36
at least of	36
site in the	36
advantage of the	36
this study we	36
is the only	36
lower respiratory tract	36
of t cells	36
and in vitro	36
performed as described	36
and the sars	36
is required to	36
g mutation in	36
was calculated as	36
figure d and	36
gene expression and	36
a member of	36
was determined using	36
and pathogenesis of	36
human ace receptor	36
by using human	36
spike protein for	36
were predicted to	36
indicated by the	36
to test whether	36
it does not	36
to the presence	36
inflammatory bowel disease	36
associated with increased	36
a broad range	36
to viral infection	36
pluripotent stem cells	36
the lung and	36
were washed with	36
were mapped to	35
phase of the	35
of the time	35
without the need	35
to a lesser	35
the increase in	35
these results are	35
a first step	35
its interaction with	35
antibody response to	35
are more likely	35
details of the	35
mouse and human	35
the goal of	35
an analysis based	35
analyses of the	35
the n gene	35
to be involved	35
at the university	35
the incorporation of	35
can be explained	35
predicted to have	35
to be highly	35
is crucial for	35
reduction in the	35
to the spike	35
of the interaction	35
washed three times	35
were included in	35
the n k	35
em structure determination	35
case of the	35
to inhibit the	35
by a single	35
to elucidate the	35
hour at room	35
spike protein to	35
this can be	35
were shown to	35
to perform the	35
the application of	35
previous studies have	35
were seeded in	35
in real time	35
th and th	35
neutralizing antibody response	35
was not peer	35
incubated with the	35
from the sars	35
we have shown	35
the average of	35
of these mutations	35
the top of	35
some of these	35
control of the	35
the primary site	35
genome sequences of	35
in a similar	35
the roles of	35
defined by the	35
with the novel	35
immune response and	35
the response to	35
top of the	35
an in silico	35
in mammalian cells	35
been reported that	35
has shown that	35
s c t	35
van der waals	35
i and ii	35
from clinical samples	35
viral and host	35
next generation sequencing	35
of the lungs	35
h k me	35
for the study	35
which is consistent	35
tumor necrosis factor	35
s p a	35
of human coronavirus	35
disease caused by	35
is given by	35
in the supernatant	35
mediated isothermal amplification	35
test was used	35
of minor variants	35
institutes of health	35
set out to	35
of the c	35
were placed in	35
it is therefore	35
performed in the	35
which could be	35
in figure d	35
a mixture of	35
multiple comparisons test	35
were maintained in	35
protein and the	35
plates were incubated	34
given that the	34
there are two	34
from the ncbi	34
clinical course and	34
atcf l ko	34
used to predict	34
a critical role	34
a human monoclonal	34
washed twice with	34
results in the	34
for statistical computing	34
as a positive	34
this is not	34
in our analysis	34
and allowed to	34
were collected and	34
identification of the	34
the affinity of	34
a minimum of	34
in health and	34
these findings suggest	34
can be a	34
even though the	34
was found that	34
analysis on the	34
for this purpose	34
and to the	34
cells treated with	34
important to note	34
as a novel	34
as can be	34
of vero e	34
spike protein in	34
we hypothesize that	34
of less than	34
fast and accurate	34
potent neutralizing antibodies	34
the host immune	34
the in vivo	34
by comparing the	34
s protein in	34
the change in	34
been used in	34
viral replication in	34
induced by the	34
as the mean	34
the construction of	34
supernatant was collected	34
reported in the	34
of the reference	34
it will be	34
well as to	34
ace in the	34
rst d i	34
t cell response	34
using graphpad prism	34
nm and nm	34
viruses such as	34
across the globe	34
emergence of a	34
has resulted in	34
rbd in the	34
absence of the	34
of protein structures	34
t a a	34
no significant difference	34
were removed from	34
given by the	34
can serve as	34
of the individual	34
to the number	34
r and r	34
in the blood	34
calculated as the	34
of the major	34
with default parameters	34
based on decade	34
in hek t	34
a basis for	34
compared to those	34
three times with	34
spike protein by	34
to control the	34
em structures of	34
for minutes and	34
supplementary table s	34
generated using the	34
rather than the	34
two types of	34
the s gene	34
have been observed	34
the vast majority	34
depend on the	34
the case for	34
accordance with the	34
has led to	34
the binding free	33
at the interface	33
and other coronaviruses	33
on the spike	33
been implicated in	33
the type i	33
we found a	33
by the fact	33
is needed to	33
of the different	33
been observed in	33
the supplementary material	33
contributes to the	33
long structural studies	33
infected with the	33
figure shows the	33
was generated using	33
caused by severe	33
consistent with our	33
that is not	33
was calculated by	33
development of covid	33
was also observed	33
of the read	33
of a new	33
here we report	33
proteins involved in	33
interaction map reveals	33
and activation of	33
average number of	33
the aim of	33
number of cells	33
after the first	33
for analysis of	33
s s c	33
viral rna in	33
smooth muscle cells	33
aspects of the	33
been reported in	33
vaccine against sars	33
on the origin	33
may be more	33
levels of ace	33
one of these	33
specific t cell	33
the likelihood of	33
of which were	33
should be considered	33
during the early	33
binding domain complexed	33
comparison to the	33
is not clear	33
in the control	33
of the sample	33
for drug repurposing	33
the first two	33
calculated for each	33
a mouse model	33
a change in	33
cloned into the	33
but not the	33
focus on the	33
mhc class ii	33
were tested for	33
possible that the	33
limited number of	33
in the sequence	33
to the covid	33
for the viral	33
in each of	33
to the primary	33
we report that	33
when compared with	33
in the structure	33
early in the	33
the binding interface	33
the antiviral activity	33
that all the	33
was used in	33
all of which	33
regardless of the	33
was present in	33
to global health	33
the rbd domain	33
upstream of the	33
serves as a	33
human lung cells	33
there have been	33
in the other	33
a web server	33
that interact with	33
to have the	33
of the membrane	33
we measured the	33
at g for	33
been found to	33
a small number	33
of the manuscript	33
primers and probes	33
the interactions between	33
available from the	33
changes in sars	32
find that the	32
the a bp	32
map of the	32
reactive oxygen species	32
overview of the	32
the region of	32
not due to	32
divided by the	32
of the structure	32
as a negative	32
in a cells	32
in which a	32
level of the	32
expression profiling of	32
that the majority	32
virus replication and	32
first step in	32
number of mutations	32
implications for the	32
wild type and	32
in human lung	32
the recovery of	32
data are presented	32
had no effect	32
wide variety of	32
ferraro et al	32
genome of sars	32
infected cells and	32
are expected to	32
in mice and	32
this type of	32
is capable of	32
during the first	32
receptor binding and	32
we reasoned that	32
urgent need to	32
whole genome sequencing	32
of the new	32
fold increase in	32
induced lung injury	32
complexity of the	32
is dependent on	32
of hepatitis c	32
of the results	32
and could be	32
interaction of the	32
we assume that	32
inspection of the	32
to describe the	32
been associated with	32
novel coronavirus disease	32
to make the	32
the first syllable	32
as a model	32
is not known	32
of the genomes	32
enabled us to	32
images were acquired	32
the correlation between	32
were incubated in	32
data with implanted	32
at the highest	32
fig s a	32
as shown by	32
can be easily	32
receptor binding domains	32
be expected to	32
information on the	32
performed with the	32
concentration of the	32
with the rbd	32
in both cases	32
for a total	32
for more than	32
in of the	32
that d g	32
dynamics of sars	32
i and type	32
rate of the	32
we decided to	32
host cell entry	32
lu et al	32
to test for	32
cell epitopes in	32
in a small	32
taq dna polymerase	32
analyzed using the	32
cells per well	32
natural language processing	32
single nucleotide polymorphisms	32
incubated for h	32
of the observed	32
of b cell	32
only a few	32
by the presence	32
we describe the	32
of the mutation	32
of these viruses	32
s p t	32
by the virus	32
in the mouse	32
the current sars	32
the t cell	32
pathogenesis of covid	32
formation of the	31
they can be	31
epitope in the	31
the type of	31
not included in	31
the mechanisms of	31
for the human	31
is driven by	31
distribution of ace	31
for each cell	31
pl pro cov	31
carried out with	31
all three viruses	31
this may be	31
they have no	31
of cells with	31
this study is	31
stability of sars	31
are in the	31
excluded from the	31
uptake in the	31
the authors would	31
were defined as	31
regulatory t cells	31
to use the	31
may have been	31
were cultured in	31
with ml of	31
also observed in	31
of the epidemic	31
here we show	31
targets for drug	31
associated with sars	31
in a mouse	31
on the s	31
on the right	31
and h n	31
t cells with	31
the susceptibility of	31
correlation between the	31
not present in	31
the central nervous	31
a fraction of	31
c t a	31
as the number	31
was subjected to	31
of the mouse	31
pathogenesis of sars	31
viral life cycle	31
g for minutes	31
and b cell	31
over the course	31
the results showed	31
was assessed by	31
that most of	31
a volume of	31
to assess whether	31
a wide variety	31
a and a	31
the secondary structure	31
the negative control	31
and immunogenicity of	31
it is well	31
according to a	31
the complexity of	31
in any of	31
also found that	31
of the gene	31
could lead to	31
and gene expression	31
patients with sars	31
in the ace	31
area under the	31
evidence that the	31
in the binding	31
of the positive	31
we show the	31
tissue distribution of	31
pandemic caused by	31
in the model	31
the idea that	31
even in the	31
of positive selection	31
of cell types	31
bronchial epithelial cells	31
of the input	31
a model for	31
in one of	31
at a time	31
from the analysis	31
responses to the	31
and centrifuged at	31
a maximum of	31
is also a	31
to the control	31
that might be	31
associated with acute	31
the reaction was	31
only a single	31
more than million	31
machine learning methods	31
protein and its	31
membrane fusion and	31
a significant increase	31
was predicted to	31
to the most	31
were performed as	31
in the dataset	31
taken into account	31
we chose to	31
coronavirus disease in	31
in comparison with	31
by plaque assay	31
been reported for	31
be caused by	31
african green monkey	31
enriched in the	31
one or two	31
of the genus	31
enzyme is a	31
center of the	30
the establishment of	30
percentage of the	30
during the course	30
d structure of	30
t cell immunity	30
of the clinical	30
be attributed to	30
estimates of the	30
were performed with	30
for the prevention	30
dna and rna	30
replication of the	30
influenza a viruses	30
the understanding of	30
here we present	30
were generated by	30
analysis showed that	30
given in table	30
s d and	30
of human coronaviruses	30
upper respiratory tract	30
the intensity of	30
complexed with receptor	30
compared to a	30
viral genomic rna	30
can bind to	30
of the global	30
e and f	30
the way for	30
to understand how	30
in the nsp	30
contact with the	30
and have been	30
in clinical samples	30
to compute the	30
in the whole	30
depicted in figure	30
the human host	30
the viral infection	30
in the top	30