1 a (yL^^'iJ^.Zuy^yn^i^^^ji^ THE LIBRARY OF THE UNIVERSITY OF CALIFORNIA PRESENTED BY PROF. CHARLES A. KOFOID AND MRS. PRUDENCE W. KOFOID 4 Digitized by tine Internet Arciiive in 2008 witii funding from IVIicrosoft Corporation littp://www.arcliive.org/details/bodymindinquiryiOOmaudricli BODY AND MIND: AN INQUIRY INTO THEIR CONNECTION AND MUTUAL INFLUENCE, SPECIALLY IN REFERENCE TO MENTAL DISORDERS. GTJLSTONIAN LECTURES FOR 18T0, DELIVERED BEFORE THE BOTAL COLLEGE OF PHTSICIANS. WITH APPENDIX. HENRY MAUDSLEY, M. D., Lond., FELLOW OF THE ROYAL COLLEGE OF PHYSICIANS ; PKOFESSOR OF MEDICAL JURISPRUDENCE IN UNIVERSITY COLLEGE, LONDON ; PRESIDENT-ELECT OF THE MEDICO-PSYCHOLOGICAL ASSOCIATION ; HONORARY MEMBER OF THE MEDICO-PSYCHOLOGICAL SOCIETY OF PARIS, OF THE IMPERIAL SOCIETY OF PHYSICIANS OF VIENNA, AND OF THE SOCIETY FOR THK PROMOTION OF PSYCHIATRY AND FORENSIC PSYCHOLOGY OF VIENNA, FORMERLY RESIDENT PHYSICIAN OF THK MANCHESTER ROYAL LUNATIC HOSPITAL, ETC. NEW YORK : r>. APPLETON AND COMPANY, 90, 92 & 94 GEAND STREET. 1871. N-- IJ> T ' o I PKEFACE The three lectures forming the first part of this volume were delivered before the Royal College of Physicians of London, to which I had the honor of being appointed Gulstonian Lecturer for this year; the latter part consists of two articles which, having appeared elsewhere, are reprinted here as presenting a completer view of some points that are only touched upon in the lectures ; and the general plan of the whole, as thus constituted, may be described as being to bring man, both in his physical and mental rela- tions, as much as possible within the scope of scientific inquiry. The first lecture is devoted to a general survey of the Physiology of Mind — to an exposition of the phys- ical conditions of mental function in health. In the second lecture are sketched the features of some forms of degeneracy of mind, as exhibited in morbid varieties of the human kind, with the purpose of bringing prominently into notice the operation of physical M31S904 iv PREFACE. causes from generation to generation, and the rela- tionship of mental to other disorders of the nervous system. In the third lecture, which contains a gen- eral survey of the pathology of mind, are displayed the relations of morbid states of the body to disor- dered mental function. I would fain believe the gen- eral result to be a well-warranted conclusion that, whatever theories may be held concerning mind and the best method of its study, it is vain to expect, and a folly to attempt, to rear a stable fabric of mental science, without taking faithful account of physiologi- cal and pathological inquiries into its phenomena. In the criticism of the " Limits of Philosophical Inquiry," which follows the lectures, will be found reasons why no attempt has been made to discuss the bearing of the views broaclied in them on any system of philosophy. Neither materialism nor spiritualism are scientific terms, and one need have no concern with them in a scientific inquiry, which, if it be true to its spirit, is bound to have regard only to what lies within its powers and to the truth of its results. It would seem to be full time that vao^ue and barren disputations concerning materialism and spiritualism should end, and that, instead of continuing such fruit- less and unprofitable discussion, men should apply themselves diligently to discover, by direct interroga- tion of Nature, how much matter can do without spir- itual help. Let each investigator pursue the method PREFACE. V of research which most suits the bent of his genius, and here, as in other departments of science, let each system be judged by its fruits, which cannot fail in the end to be the best G23onsors and sureties for its truth. But the physiological inquirer into mind may, if he care to do so, justly protest against the easy con- fidence with which some metaphysical psychologists disdain physiological inquiry, and ignore its results, without ever having been at the pains to make them- selves acquainted with what these results are, and with the steps by which they have been reached. Let theory be what it may, there can be no just question of the duty of observing faithfully all the instances which mental phenomena offer for inductive inquiry, and of striving to realize the entirely new aspect which an exact study of the physiology of the nervous system gives to many problems of mental science. One reflection cannot fail to occur forcibly to those who have pursued this study, namely, that it would have been well could the physiological inquirer, after rising step by step from the investigation of life in its lowest forms to that of its highest and most complex manifestations, have entered upon his investigations of mind without being hampered by any philosophi- cal theories concerning it. The very terms of met- aphysical psychology have, instead of helping, op- pressed and hindered him to an extent which it is im- possible to measure: they have been hobgoblins to vi PREFACE. frighten him from entering on his path of inquiry, phantoms to lead him astray at every turn after he has entered upon it, deceivers lurking to betray him under the guise of seeming friends tendering help. Let him take all the pains in the world, he cannot ex- press adequately and exactly what he would — neither more nor less — ^for he must use words which have al- ready meanings of a metaphysical kind attached to them, and which, when used, are therefore for him more or less a misinterpretation. He is thus forced into an apparent encroachment on questions which he does not in the least degree wish to meddle with, and provokes an antagonism without ever designing it; and so one cannot but think it would have been well if he could have had his own words exactly fitting his facts, and free from the vagueness and ambiguity of a former metaphysical use. The article on the " Theory of Vitality," which ap- peared in 1863, is now reprinted, with a few, mainly verbal, alterations. The aspect of some of the ques- tions discussed in it has been somewhat changed by the progress of inquiry and thought since that time, but it appears to the Author that, great as discussion has been, there are yet considerations respecting vitali- ty that have not been duly weighed. Whether living matter was formed originally, or is now being formed, from non-living matter, by the operation of physical causes and natural laws, are questions which, notwith- PREFACE. vii Standing the lively and vigorous handling which they have had, are far from being settled. Exact experi- ment can alone put an end to this dispute : the one conclusive experiment, indeed, in proof of the origin of living from dead matter, will be to make life. Meanwhile, as the subject is still in the region of dis- cussion, it is permissible to set forth the reflections which the facts seem to warrant, and to endeavor to indicate the direction of scientific development which seems to be foretokened by, or to exist potentially in, the knowledge which we have thus far acquired. This much may be said : that those who oppose the doc- trine of so-called spontaneous generation, not on the ground of the absence of conclusive evidence of its occurrence, which they might justly do, but on the ground of what they consider special characteristics of living matter, would do well to look with more in- sight into the phenomena of non-living Nature, and to consider more deeply what they see, in order to dis- cover whether the characteristic properties of life are quite so special and exclusive as they imagine them to be. Having done that, they might go on to consider whether, even if their premises were grant- ed, any conclusion regarding the mode of origin of life would legitimately follow; whether in fact it would not be entirely gratuitous and unwarrantable to con- clude thence the impossibility of the origin of living matter from non-living matter. The etymological im- viii PREFACE. port of the words physics and physiology is notably the same ; and it may be that, as has been suggested, in the difference of their application lies a hidden irony at the assumption on which the division is grounded. 9, Hanover Square, W. November 5, 1870. CONTENTS. LECTURES. PAGE I. — On the Physical Condition of Mental Function in • Health . . . . . .11 II._On Certain Forms of Degeneracy of Mind, their Causation, and their Relations to other Dis- orders of the Nervous System . . . 41 III. — On the Relations of Morbid Bodily States to Dis- ordered Mental Functions . . . .10 APPENDIX. I. — The Limits of Philosophical Inquiry . . 98 II. — The Theory of Vitality . . . . .120 BODY AND MIND: AN INQUIKY INTO THEIR CONNECTION AND MUTUAL INFLUENCE, SPECIALLY IN EEFERENCE TO MENTAL DISOEDEES. LECTURE I. Gentlemex: The relations of mind and body in health and in disease I have chosen as the subject of these lectures, not with the hope of doing full justice to so complex and difficult an inquiry, but because it has for some time been my special work, and there was no other subject on -which I should have felt myself equally justified in addressing you. No one can be more deeply sensible than I am how little exact our knowledge is of the bodily conditions of mental functions, and how much of that which we think we know is vague, uncertain, and fluctuating. But the time has como when the immediate business which lies before any one who would advance our know^ledge of mind unquestionably is a close and searching scrutiny of the bodily conditions of its manifestations -in health and disease. It is most necessary now to make use of the results of the study of mind in health to light and guide our researches into its morbid phe- nomena, and in like manner to bring the instructive in- stances presented by unsound mind to bear upon the inter- pretation of its healthy functions. The physiology and the pathology of mind are two branches of one science ; and he 12 BODY AXD MIXD. who studies the one must, if he would work wisely and wel], studj the other also. My aim will he to promote the recon- ciliation hetween them, and in doing so I shall embrace the occasion, whenever it offers itself, to indicate the principles which should guide our efforts for what must always be the highest object of medical science and art — the production and preservation of a sound mind in a sound body. Act- ually to accomplish much of this purpose will not lie in my power, but I may bring together fragmentary observa- tions, point out the bearing of them on one another and on received opinions, thus unfold their meaning, and mark broadly the lines which future research must take. "Within the memory of men now living insanity was such a spet-ial study, and its treatment such a special art, that it stood quite aloof from general medicine in a mysterious and mischievous isolation ; owing little or nothing to the results of progress in other branches of medicine, and contributing nothing to their progress. The reason of this it is not hard to discover. The habit of viewing mind as an intangible entity or incorporeal essence, which science inherited from theology, prevented men from subjecting its phenomena to the same method of investigation as other natural phenom- ena; its disorders were thought to be an incomprehensible affliction and, in accordance with the theological notion, due to the presence of an evil spirit in the sufferer, or to the en- slavement of the soul by sin, or to any thing but their true cause — bodily disease. Consequently, the treatment of the insane was not in the hands of intelligent physicians, who aimed to apply the resources of medicine to the alleviation or cure of bodily illness, but was given up to' coarse and ig- norant jailers, whose savage cruelties will for all time to come be a great and ugly blot upon the enlightenment of the age which tolerated them. Matters are happily changed now. On all hands it is ad- mitted that the manifestations of mind take place through the nervous system; and'that its derangements arc the result ORGAN AND FUNCTION. 13 of nervous disease, amenable to the same method of investi- gation as other nervous diseases. Insanity has accordingly become a strictly medical study, and its treatment a branch of medical practice. Still, it is all too true that, notwith- standing we know much, and are day by day learning more, of the physiology of the nervous system, we are only on the threshold of the study of it as an instrument subserving men- tal function. We know little more positively than that it has such function ; we know nothing whatever of the physics and of the chemistry of thought. The conception of mind as a mysterious entity, diiferent essentially from, and vastly supe- rior to, the body which it inhabits and uses as its earthly tene- ment, but from which its noblest aspirations are thought to be to get free, still works openly or in a latent way to ob- struct the study of its functions by the methods of physical research. Without speculating at all concerning the nature of mind — v»^hich, let me distinctly declare at the outset, is a question which science cannot touch, and I do not dream of attempting to touch — I do not shrink from saying that we shall make no progress toward a mental science if we begin by depreciating the body : not by disdaining it, as metaphy- sicians, religious ascetics, and maniacs have done, but by laboring in an earnest and inquiring spirit to understand it, shall we make any step forward; and when we have fully comprehended its functions, when we know how to estimate fitly this highest, most complex, and wonderful achievement of organized skill, it will be quite time, if there be then the inclination, to look down upon it with contempt. The truth is, that in inquiries concerning mind, as was once the case in speculations concerning other natural phe- nomena of forces, it has been the practice to begin where the inquiry should have ended. Just as the laws of physical ac- tions were evoked out of the depths of human consciousness, and the relations of bodies to one another attributed to sym- pathies and antipathies, attractions and abhorrences, instead 14 BODY AND MIND. of being acquired by patient observation and careful generaliza- tion, so has a fabric of mental philosophy been reared on the doubtful revelations of self-consciousness, in entire disregard of the more tedious and less attractive duty of observation of facts, and induction from them. Surely it is time we put seriously to ourselves the question whether the inductive method, which has proved its worth by its abundant fruit- fulness wherever it has been faithfully applied, should not be as rigidly used in the investigation of mind as in the investigation of other natural phenomena. If so, we ought certainly to begin our inquiry with the observation of the simplest instances — with its physiological manifestations in animals, in children, in idiots, in savages, mounting by de- grees to the highest and most recondite facts of consciousness, the interpretation or the misinterpretation of which consti- tutes what has hitherto claimed to be mental philosophy. The inductions which we get by observing the simple may be used with success to disentangle the phenomena of the complex ; but the endeavor to apply the complex and obscure to the interpretation of the simple is sure to end in confusion and error. The higher mental faculties are formed by evolution from the more simple and elementary, just as the more spe- cial and complex structure proceeds from the more simple and general ; and in the one case as in the other we must, if we would truly learn, follow the order of development. Not that it is within my present purpose to trace the plan of development of our mental faculties, but the facts and argu- ments which I shall bring forward will prove how vain and futile it is to strive to rear a sound fabric of mental sci- ence on any other foundation. To begin the study of mind, then, with the observation of its humblest bodily manifestations is a strictly scientific method. When we come to inquire what these are, it is far from easy to fix the point at which mental function begins. Without doubt most of the actions of man, and many of those of the higher animals, do evince the operation of mind, REFLEX ACTION. 15 but whereabouts in the animal kingdom it first appears, and what part it has in the lower nerve-functions of man, arc questions not easily answered. The more closely the matter is looked into, the more clearly it appears that we habitually embrace in our conception of mind different nervous func- tions, some of which proceed from different nerve-centres, and the more necessary it becomes to analyze these functions, to separate tlie more simple and elementary, and to discover in the concrete as much as possible of the meaning of the abstraction. Is the brain the exclusive organ of mind? If it be so, to what category of functions shall we refer the re- flex acts of the spinal cord, which take place independently of the brain, and which often achieve as definite an end, and seem to display as intelligent an aim, as any conscious act of volition? It needs not to illustrate in detail the nature and extent of reflex action, which is familiar enough, but I may select a striking example in order to serve as a text for the reflections which I wish to bring forward. One simple fact, rightly understood and truly interpreted, will teach as much as a thousand facts of the same kind, but the thousand must have been previously observed in order to understand truly the one ; for it is certainly true that, to apprehend the fidl meaning of common things, it is necessary to study a great many uncommon things. This, however, has been done in this instance by the distinguished physiologists whose labors have fixed on a tolerably firm basis the doctrine of reflex action ; we may, therefore, take, as our starting-point, the accepted results of their labors. It is well known that, if the hind-foot of a frog that has had its head cut off be pinched, it is withdrawn from the ir- ritation. The stimulus to the afferent nerve reaches the gray matter of the spinal cord, and sets free a force which excites to action the corresponding motor nerves of the same side. When the foot is pinched more strongly, the force liberated by the stimulus passes across the cord to the motor nerves of the opposite side, and there is a simultaneous withdrawal 16 BODY AND MIXD. of both limbs; and, if tbe excitation be stronger still, there is a wider irradiation of the effects of the stimulus in the gray matter, and a movement of all four limbs follows, the frog jumping away. These movements of the decapitated frog, which it is plain effect the definite purpose of getting it out of the way of harm, we believe to be analogous to the violent coughing by which food that has gone the wrong way is expelled from the human larynx, or to the vomiting by which offending matter is ejected from the stomach. Inde- pendently of consciousness and of will, an organism plainly has the power — call it intelligent or call it Avhat we will — of feeling and eschewing what is hurtful to it, as well as of feel- ing and ensuing what is beneficial to it. But the experiment on the frog may be made more striking and instructive. Touch with acetic acid the thigh of a de- capitated frog over the internal condyle, and the animal rubs it off with the dorsal surface of the foot of the same side ; cut off the foot, and apply the acid to the same spot, and the animal tries to get at it again with its foot, but, of course, having lost it, cannot. After some fruitless efforts, therefore, it gives up trying in that way, seems restless, as though, says Pfltiger, it was seeking some other way; and at last it makes use of the foot of the other leg, and succeeds in rubbing off the acid. ITotably we have here not merely contractions of muscles, but combined and harmonized contractions in due sequence for a special purpose. There are actions that have all the appearance of being guided by intelligence and insti- gated by will in an animal the recognized organ of whose in- telligence and will has been removed. What are we to say in explanation of movements that have such a look of adaptation? Are they mental, or are they only physical? If they are mental, it is plain that we must much enlarge and modify our conception of mind, and of the seat of mind ; if physical, it is plain that we must subtract from mind functions that are essential to its full function, and properties that are the very foundations of its development PURPOSIVE ACTS. 17 in the higher centres. Some eminent pliysiologists now maintain, on tlife strength of these experiments, that tlie ac- ceptod doctrine of reflex action is quite untenable, and that the spinal cord is really endowed with sensation and volition; and certainly these adapted actions seem to give us all the signs of being felt and willed, except telling us that they are so. Before accepting, however, this explanation of the ob- scure by something more obscure still, it were well to I'ealize distinctly how dangerous a practice it usually is to apply de- ductively to the interpretation of simple phenomena ideas pertaining to the more complex, and how essential a princi- ple of the method of induction it is to follow the order of evolution, and to ascend from the interpretation of the sim- ple to that of the complex. The explanation savors of the old and evil tendency which has done so much harm in phi- losophy, the tendency to explain the facts of ISTature by what we feel to go on in our minds ; because we know that most of our actions take place consciously and voluntarily,we can hard- ly help thinking that it must be the same in the frog. Might we not, however, as well suppose and hold that positive at- tracts negative and repels positive electricity consciously and voluntarily, or that in the double decomposition of chemical salts one acid chooses voluntarily the other base? It is most necessary to be on our guard against the danger of misapply- ing ideas derived from internal observation of the functions of mind-centres to the interpretation of the functions of lower nerve-centres, and so of misinterpreting them. As- suredly we have sad experience enough to warn us against involving the latter in the metaphysical haze Avhich still hangs over the functions of the supreme centres. All the conclusion w^hich the facts warrant is that actions for a definite end, having indeed the semblance of predesign- ing consciousness and will, may be quite unconscious and auto- matic ; that the movements of the decapitated frog, adapted as they are to secure its well-being, are no more evidence of intelligence and will than are the movements of coughing, 18 BODY AND MIND. sneezing, and swallowing in man. In the constitution of the animal's spinal cord are implanted the faculties of such move- ments for self-preservation, which it has inherited as a part of its nature, and without which it could hardly live a day ; accordingly it acts necessarily and blindly ; though it has lost its foot, it endeavors vainly to act as if its foot was still there, and only when the irritation continues unaffected by its futile efforts makes, in answer to it, those further reflex movements which are the physiological sequences of the unsuccessful movements: it supplements one series of reflex actions by another.* But, although these purposive movements are not evidence of intelligence and volition in the spinal cord, it is another question whether they do not evince the same physi- ological properties and the operation of the same laws of evolution as govern the development of intelligence and will in the higher centres. I have taken the experiment on the frog to exemplify the proposition that designed actions may be unconscious and automatic, because the phenomena are more simple in it than in man, and more easy therefore to be understood ; but the proposition is equally true of his spinal cord. In its case, however, we have to bear in mind that faculties are not in- nate to the same degree and extent as in the lower animals, but have to be acquired by education — to be organized, in fact, after birth. It must be taught, just as the brain must, before it can perform its functions as an organ of animal life ; and, being much more under the control of the more highly- developed brain, feeling and volition commonly mingle largely in its functions, and its independent action cannot be so plainly exhibited. But, when its motor centres have been taught, when they have gained by education the power of executing what are called secondary automatic acts, it is cer- * Wisely or unwisely, as the case may be ; for reflex movements which commonly effect a useful end may, under the changed circumstances of dis- ease, do great mischief, becoming even the occasion of violent suffering and of a most painful death. SECONDARY AUTOMATIC ACTS. 19 tain that it can and does habitually execute them indepen- dently of consciousness and of will. They become as purely automatic as are the primitive reflex acts of the frog. To the statement, then, that actions bearing the semblance of design may be unconscious and automatic we have now to add a second and most weighty proposition — namely, that acts con- sciously designed at first may, by repetition, become uncon- scious and automatic, the faculties of them being organized in the constitution of the nerve-centres, and they being then performed as reflex effects of an external stimulus. This law, by which the education of the spinal cord takes place, is, as we shall hereafter see, a most important law in the develop- ment of the higher nerve-centres. Let us now go a step further. The automatic acts, whether primary or secondary, in the frog or in the man, which are excited by tlie suitable external stimulus, may also be excited by an act of will, by an impulse coming downward from the brain. "When this happens, it should be clearly apprehended that the immediate agency of the movements is the same ; it is in the motor centres of the spinal cord; the Avill does not and cannot act upon the nerve-fibres of each muscle individu- ally, but simply gives the order which sets in motion the or- ganized machinery of the movements in the proper motor centres. This is a consideration of the utmost importance, for it exhibits how great a part of our voluntary acts is really the automatic action of the spinal cord. The same move- ments are effected by the same agency in answer to dififerent stimuli — in the one case to an external stimulus, in the other case to an impulse of will ; and in both cases the mind is alike ignorant of the immediate agency by which they are done. But while the automatic acts take place independently of will, the will is absolutely dependent on the organized expe- rience in the cord for the accomplishment of its acts ; with- out this it would be impotent to do a voluntary act. TThen, therefore, we have taken out of a voluntary act the large part which is due to the automatic agency of the motor cen- 20 BODY AND MIXD. tres, it clearly appears that we have subtracted no small proportion from what we are in the habit of comprising vaguely under mind. We perceive, indeed, how indispensa- ble an exact and faithful observation of the functions of the spinal cord is to a true physiological inquiry into mind, and what an important means of analysis a knowledge of them yields us. Carrying the knowledge so gained into our exami- nation of the functions of the higher nerve-centres, we ob- serve how much of them it will serve to interpret. The re- sult is, that we find a great part of the habitual functions of the higher centres to be similarly automatic, and to admit of a similar physiological interpretation. There can be no doubt that the ganglionic nuclei of the senses — the sensorial nuclei — are connected with motor nu- clei ; and that we have in such anatomical arrangement the agency of a number of reflex movements. Most of the in- stinctive acts of animals are of this kind, the faculties being innate in them. In man, however, who is actually the most helpless, though potentially the most powerful, of all living creatures when he comes into the world, the sensory and associated motor nuclei must be educated, just as the spinal centres must. To illustrate this sensori-motor or instinctive action, we may take the results of Flourens's well-known experiment of removing the cerebral hemispheres of a pigeon. What happens ? The pigeon seemingly loses at once all in- telligence and all power of spontaneous action. It appears as if it were asleep ; yet, if thrown into the air, it will fly. If laid on its back, it struggles on to its legs again ; the pupil of the eye contracts to light, and, if the light be very bright, the eyes are shut. It will dress its feathers if they are ruffled, and will sometimes follow with a movement of its head the movement of a candle before it ; and, when a pistol is fired off, it will open its eyes, stretch its neck, raise its head, and then fall back into its former attitude. It is quite evident from this experiment that general sensibility and special sensations are possible after the removal of the hemispheres ; but they SEXSORI-MOTOR ACTS. 21 are not then transformed into ideas. The impressions of sense reach and affect the sensory centres, but they are not intel- lectually ^C7'm2;'ith Nature and ends with himself; he is the complex to which his in- vestigations ascend step by step through progressively in- creasing complications of the simple. Not only so, but the necessity of studying himself objectively is fully recognized ; it is not the subjective feeling of heat or cold in a feverish patient, but the figure at which the thermometer stands, that is now appealed to as the trustworthy index of the real tem- perature. The development of the senses, or, in other words, the increased specialty of human adaptation to external Na- ture, has been, as the progress of science proves, the founda- tion of intellectual advance ; the understanding has been de- veloped through the senses, and has in turn constructed in- struments for extending the action of the senses.* The tele- scope has merely been a means for enabling the eye to pene- trate into distant space, and to observe the motions of worlds which the unaided vision Vv^ould never have revealed ; by the microscope the minute structure of tissues and the history of * A great desideratum is a history of such development of the Benses : " Wir besitzen gar treffliche Werke uber die Geschichte von Schlachten und Staatsformen, genaue Tagebucher von KOnigen und flcissige Verzeich- iiisse von den SchOpfungen der Dichter. Aber den wichtigsten Beitrag zu einer Bildungsgeschichte des Menschen in der eingreifendsten Bedeutung des Wovtes hat noch Niemand geliefert. Una fehlt eine Entwickelungs- ge?chii;hte der Sinne."— ^Moleschott, Kreislmif des Lebens. 124 THE THEORY the little world of the organic cell have been made known ; the balance has demonstrated the indestructibility of matter, and has supplied to science the exactness of the numerical method ; and, in the electric stream, there has been found a means of investigating nerve-action, like that which there is in polarized light for ascertaining the internal condition of crystallized bodies. Who would have ventured to predict some time since that it would ever be possible to measure the speed at which an impulse of the will travels along the nerves ? * And who will venture to say that it will not at a future time be possible to measure the velocity with which one idea calls up another in the brain ? Biology must plainly of necessity be the last and most difficult study, for it pre- supposes the other sciences as vital force supposes inferior forces ; but it is the evident tendency of advancing knowl- edge to bring life more and more within the compass of sci- entific investigation. And if it be sometimes made a reproach to science, as it was by Comte, that it has not discovered the laws of life, it may well rest calm under the censure, point- * Such an eminent physiologist as Miiller could venture to predict the impossibility thereof. In his Physiology he says : " Wir werden auch wohl nie die Mittel gewinnen die Geschwindigkeit der Nervenwirkung zu ermit- teln da uns die Vergleich ungeheurer Entfernung felht aus der die Schnel- ligkeit einer dem Nerven in dieser Hinsicht analogen Wirkung des Licht berechnet werden kann," With which compare Helmboltz: " Ueber die Methoden kleinste Zeittheilchen zu messen," etc. 1850. As long as physiologists considered it necessary to refer the operations of the nerves to the extension of an imponderable or psychical principle, it might well appear incredible that the rapidity of the stream should be measurable within the limits of the animal body. At present we know, from the investigations of Du Bois-Reymond on the electro-motor proper- ties of nerves, that the activity by which the propagation of a stimulus is accomplished is closely connected Avith an altered arrangement of their ma- terial molecules— perhaps even essentially determined by them. Accord- ingly, the process of conduction in nerves may belong to the series of con- tinuous molecular operations of ponderable bodies, in which, for example, the conduction of sound in the air, or the combustion in a tube filled with an explosive mixture, is to be reckoned. It is not surprising therefore," he adds, " that the speed of conduction should be very moderate." (XJcber die Methoden, etc.) OF VITALITY. 125 ing to the history of the earth to show that Nature, having done all else, required a long period before it accomplished the evolution of life. In spite, then, of a desire on the part of some persons to separate biology from the other sciences, and, notwithstand- ing the alarm occasionally displayed with regard to the dig- nity of vitality, it is the certain tendency of advancing knowledge to bring a science of life into close and indissolu- ble relations with other sciences, and thus to establish in cognition, or to reflect in consciousness, the unity which exists in Nature. AYhen, in ancient times, life Avas assigned to the stars, the air, the water, a sort of unity Avas recog- nized, but recognized only by explaining Nature from a very imperfect knowledge of man ; now the task is to explain man on the basis of an increasing knowledge of Nature, and in that way to demonstrate the unity of the whole. "What must be the result ? Nothing less, indeed, than the reconciliation of the ideal and the real, the identification of subjective and objective. As life is a condition in Avhich an intimate corre- lation exists between the individual and Nature, it is CA^ident that, while Plato dealt only with ideas of the mind, his sys- tem must remain comparatively unprofitable ; but it is evi- dent also that, since Ave have learned to discover the Imcs or ideas in Nature of which ideas in the mind are correlates, it becomes possible to find in Nature an interpretation of Plato's true ideas.* Once for all, it may perhaps be taken for granted that the ideas of genius never can be meaningless ; for its mental life is a reflection in consciousness of the un- conscious life of Nature. How excellently has this been ex- emplified in him who embodied in poetical form the scientific spirit of this age ! It was the great characteristic of Goethe, * "But it is manifest that Plato, in his opinion of ideas as one that had a wit of elevation situate as upon a clilf, did descry 'that forms were the true object of knowledge,' but lost the real fruit of his opinion by consider- ing of forms as absolutely abstracted from matter, and not confined and de- termined by matter ; and so turning his opinion on theology, wherewith all his natural philosophy is infected."— Z)3 Aug. Sclent. 126 THE THEORY as Lavater justly said of him, to give a poetical form to tlic real ; he proved, in fact, that science, in place of rendering poetry impossible, opened a field for the highest poetry. His romance of the Elective Affinities {Wahlverwandschaften) starts from the chemical affinities of elements, and applies such affinities to human beings, therein exactly reversing the old method, which, starting from the phenomena of self-con- sciousness, applied the passions of the human mind to the phenomena of external Nature. Of Goethe it may be justly said, that in him the ideal and the real were happily blended; that he embodied the scientific spirit of the age, and yet was in some respects an advance upon it ; that he was a prophecy of that which must be a course of development of the human mind if it be destined to develop. The foregoing general sketch of the course and tendency of knowledge is fully justified by the present aspect of sci- ence. When ISTature was first examined objectively the dif- ferences in matter appeared manifold, and its modes of energy or activity — that is, its forces — appeared many also. On a more careful use of the senses, however — in fact, by the ap- plication of the delicate balance to the products of combus- tion — it became evident that one form of matter only disap- peared to reappear in another form ; that it never perished, but only changed. Elementary matter tlms passes upward into chemical and organic compounds, and then downward from organic to chemical, and from chemical compounds to its elementary condition. Out of dust man is formed by an upward transformation of matter, and to dust he returns by a retrograde metamorphosis thereof. Corresponding with the changes in the form of matter are changes in its modes of energy or its forces ; to different combinations and ar- rangements of molecules correspond diff'erent modes of en- ergy. Eorce therefore is eternal, like matter, and passes through a corresponding cycle of transformations. The cor- relation and conservation of forces, which have always been more or less clearly recognized as necessities of human OF VITALITY. 127 thought, are now accepted as scientific axioms, and are daily receiving experimental demonstration.* Though it may seem difficult to avoid the conclusion that there is fundamentally but one natural force which manifests itself under different modes, yet such a supposition at present transcends the domain of science. As a matter of fact we are compelled, in order to form a satisfactory conception of mat- ter and its forces, to regard it under a twofold aspect. In all our conceptions we imply a sort of dualism of power in every body, though we are very apt to forget it in our gen- eralizations.* The hinges of gravitation, for example, keep worlds in their orbits by opposing a centrifugal force which would otherwise drive them afloat into space. The smaller hinges of molecular cohesion hold together the infinitely smaller bodies which we call molecules of matter, in opposi- tion to a repulsive force, which, on the application of a little heat, may drive them off into space, and in volatile sub- stances does so drive them off without heat. It is the same with liquids ; their diffusion power is similar in character to the volatility of solids; while " colloids " are volatile, "crys- talloids " are comparatively "fixed." There is a relation of molecules to one another which we are compelled to repre- sent in conception as the result of a force of repulsion or tension. And as some sensible image is necessary for the mind in order to the clearness of a conception of the invisi- ble, physics assumes between the ponderable molecules of a body certain ethereal particles which are in a state of sta- * Epicurns, Democritus, Aristotle, all upheld the eternity of matter; the quotations from Lucretius and Persius on that subject are well knowu, hut the following passage from the Be Angmentis Is not so common : " All things change, but nothing is lost. This is an axiom in physics, and holds in natural theology; for as the sum of matter neither diminishes nor in- creases, so it is equally the work of Omnipotence to create or to annihilate." Other passages of like import occur in Bacon's writings. And the Bra- minical doctrine is as follows : "The ignorant assert that the universe iu the beginning did not exist in its author, and that it was created out of nothing. O ye, whose hearts are pure, how could something come out of nothing?'' 128 THE THEORY tionary oscillation, the degree of temperature of the body being supposed to depend upon the intensity of the active force of these imponderable intermolecular particles. If the body be suddenly and greatly compressed, these motions are communicated to the imponderable ether outside the body, and tension force thus becomes free force in manifest radia- tion of heat. " What is heat in us," very justly said Locke, " is in the heated body nothing but motion." When heat is withdrawn from matter — that is, when the tension force be- comes free, its molecules get nearer to one another — their cohesion is greater ; thus vapors become liquids* and liquids become solids. It seems probable that the necessity of regarding matter under this twofold aspect of attraction and repulsion is owing to man's inability, as being himself a part of Nature, to form a conception of Nature as a whole. He must necessarily re- gard things in relation to himself; for as he exists only in relation to Nature, and as every phase of consciousness is an expression of this relation, it is plain that one of the elements of the relation cannot free itself, and from an independent point of view watch unconcernedly things as they really are. Thus, though we speak of passivity and activity, they are really not different kinds of action, but different relations of the same kind of action. Whatever be the cause, and how- ever doubtful the philosophical validity of the distinction, we are compelled to regard matter in this twofold relation. One aspect of the relation we describe as passive, statical, cohesion, or, to use the generic term, attraction; the other is active, dynamical, tension, or, to use the generic term, re- pulsion. Attraction plus repulsion of molecules constitutes our conception of matter ; and, in observation of its modes of energy, attraction is recognized in gravitation, cohesion, magnetism, affinity, love, while repulsion is found in the cen- trifugal force, in heat, in electricity, in antipathy, and hate. It is in rising to the department of chemical compounds that attraction is found under a new and special phase as OF VITALITY. 129 cliemical affinity. But, when the chemical union of two mol- ecules into a single one takes place, a diminution of the ten- sion force surrounding each molecule must occur, and, accord- ing to the law of the conservation of force, an equivalent of another force must be set free. This happens in tlie produc- tion of heat and electricity ; for, as Faraday has shown, chemical action cannot take place without the development of electricity. The amount of force liberated in a simple chemical combination will be the equivalent of the tension force lost. When one atom of carbon combines with one atom of oxygen, a definite quantity of tension force surrounding each molecule disappears, and a definite quantity of heat is accord- ingly produced. When two molecules separate in chemical de- composition, they necessarily make passive or latent so much active force ; so much heat becomes so much tension force. But furthermore, in a chemical decomposition we have the resolution of that very intense and special force, chemical aflSnity itself; so that the force set free will, one would sup- pose, far exceed that which becomes latent as tension force around the molecules. We know not why two molecules should chemically combine ; we accept as a fundamental law of their nature this high, special, and powerful form of at- traction ; but we do know that, when chemical decomposition takes place, a little chemical force must be resolved into a large display of* inferior force. It is a fact authenticated by Faraday, that one drop of water contains, and may be made to evolve, as much electricity as under different modes of display would suffice to produce a lightning-flash. The decomposition of matter is the resolution of force, and in such resolution one equivalent of chemical force will corre- spond to several equivalents of inferior force. Thus chemical force, though correlated with the physical forces, may be said to be of a much higher order than they are. In the still higher stage of matter in a state of vitality, we meet with chemical combination of a much more complex character than occurs in inorganic matter ; attraction appears 130 THE THEORY under its most special and complex form. Matter, which in its elementary condition might occupy some space, is so blended or combined as to occupy a minimum ot space ; and force, which, under a lower mode, might suffice perhaps to illuminate the heavens, is here confined within the smaU compass of an organic cell or of a speck K)f protoplasm. "We have to do, however, with organic matter under two forms — as dead and as living matter, as displaying energy of its own, or as displaying no energy. Dead organic matter has ceased to act, and it is now acted upon ; it is at the mercy of the forces which surround it, and immediately begin to effect its dissolution. Heat hastens decomposition, because in the separation of the constituents of organic matter into the ultimate inorganic products — carbonic acid, ammonia, and water — a certain amount of active force must become latent as the tension force of these molecules ; and this force the heat supplies. There is also the force of the chemical affinity of the oxygen of the air for the oxidizable elements of the substance ; and the combination is necessarily attended with the production of heat. The heating value of organic matter will accordingly increase with the quantity of oxidizable ele- ments; but the matter is by no means so simple as it might at first sight appear to be. Suppose the atom of carbon, with which an atom of oxygen combines was previously in com- bination with, for example, an atom of hydrogen ; and the question is, whether the amount of heat produced will be the same as though the atom of carbon had been free ? In reality it will not ; it must be less, because in the separation of the carbon atom and the hydrogen atom so much active force must become tension force — that is, so much heat must dis- appear or become latent; and that loss of heat will neces- sarily counterbalance a part of the heat produced, or the decrease of tension force which occurs, through the combi- nation of the atom of carbon with the atom of oxygen. It is this consideration which appears to invalidate some experi- ments made and conclusions come to with regard to animal heat. OF VITALITY. 131 But there is another consideration. In this mere burning or decomposition of organic matter, or that wliich represents tlie passive, statical, or attractive phase of vitality, the active force which results is due partly to force from -without, and not solely to the liberation of force latent in the matter. Ex- ternal forces have, as it vt-ere, been pulling it to pieces. What, then, on the principle of the conservation of force, becomes of that intense chemical force which is implied in the organic nature of the material, that power which holds it together as a specific material diftering in properties from all kinds of inorganic matter ? Though dead, the chemical composition of organic substance is the same as when alive ; and its future destiny is entirely dependent on the circum- stances in which it may be placed. In the air, it is true, it will undergo decomposition into inorganic products ; but, if it be surrounded with the conditions of life, if it be exposed to the influence of higher forces, by being given as food to some animal, it does not go downward, but upward, and somehow takes on life again. It is plain what becomes of the statical force under the latter circumstances. But, in the decomposition of organic matter in the air and the correlative resolution of force, it is not so evident what becomes of all the force which must be liberated. That it returns to general Nature can admit of no doubt; but does it all appear as heat? A part of it must necessarily do so, becoming latent as the tension force of the molecules of the ultimate products of its decomposition, and the rest is liberated under some form or other, if not entirely as heat. There is some reason to believe, however, that dead organic substance does not always un- dergo the extreme retrograde metamorphosis of material and of force before being used up again in vital compounds, even by the vegetable kingdom. It has been shown that not only do pale plants, such as fungi, feed on organic matter, but that soluble humus is regularly taken up by the roots of al- most all plants. Prof. Le Conte has shown it to be probable that the decomposition of the organic matter supplies the 132 THE THEORY force necessary for raising other matter from a lower to a higher stage.* The force necessary, for organization is thus furnished bj the force which results from disorganization ; death and destruction are the conditions of life and devel- opment. When organic matter displays energy — that is, when it has life — its relations with its surroundings are diiferent. As chemical aflSnity seems to hold the place of attraction in it, and to correspond to gravitation among celestial bodies, cohesive force among molecules, and magnetic force among polar molecules, so its dynamical or vital action seems to cor- respond to the force of repulsion, to the centrifugal force of heavenly bodies, the tension force of molecules, and electrical repulsion. The display of energy coincides with a molecular change in the statical element. With the function of a gan- glionic nerve-cell, for example, a correlative molecular change, or "waste," as it is called, necessarily takes place either in the nerve-element itself or in what is supplied to it from the blood. The substances which are met with in the so-called extractives of nerve-tissue afford abundant evidence of a ma- terial waste ; for as products of the retrograde metamorphosis are found lactic acid in considerable quantities, kreatin, uric acid, probably also hypoxanthin, and, representing the fatty acids, formic and acetic acid.t And what Du Bois-Eeymond proved to happen in muscle, Funke has observed to happen also with nerve : while the contents of nerve-tubes are neutral during rest in the living state, they become acid after death, and also after great activity during life. After excessive mental exercise, it is well known that phosphates appear in * The Correlation of Physical, Chemical, and Vital Force, and the Con- servation of Force in Vital Phenomena. By J. Le Conte, Professor of Ge- olo^ and Chemistry in South Carolina College. (American [Journal of Science and Arts, No. 28, 1859.) t It is interesting to remark how the products of chemical transformation resulting from nerve-action agree with the products of decomposition after muscular activity, and how the results coincide with what, a priori, might have been expected from the great vital activity of nerve-structure. OF VITALITY. 133 the urine in considerable quantities ; and it is only by sup- posing an idea to be accompanied by a correlative change in the nerve-cells that we can explain the bodily exhaustion which is produced by mental labor, and the breaking down of the brain under prolonged intellectual efforts. There is even at times a sensation of something going on in the brain ; and, in insanity, such anomalous feelings are sometimes per- sistently complained of. But the change or waste which accompanies energy is restored by nutrition during rest, and the conditions of future energy are thus established ; nutritive attraction steadily repairing the waste of centrifugal function. The cell thus, for a time at least, preserves its individuality ; and definiteness of energy, with the maintenance of individ- uality, is what is connoted by vitality. Is the energy displayed by living matter something quite special? In attempting to answer that question, two consid- erations should be kept in view. In the first place, an effect need not at all resemble in properties its cause ; the qualities of a chemical compound are quite different from those of its constituents. Such a complex compound as organic matter really is may be expected, therefore, to exhibit peculiar prop- erties in no way resembling those of its constituent elements or those of simple compounds. In the second place, the ar- rangement or grouping of the molecules in a substance, inde- pendently of its chemical composition, may greatly alter its properties : there is a molecular as well as a chemical consti- tution of matter. In that condition of bodies which is de- scribed as Isomerism, there are atoms alike in number, nature, and relative proportion, so grouped as somehow to produce compounds having very different chemical properties. Again, it has been found that the same matter may exist under two very different conditions, and with very different properties — as colloidal and as crystalloidal, in a gelatinous or in a crys- talline state. And what is the chief difference? It is that the colloidal is a dynamical state of matter, the crystalloidal a statical state. The colloid exhibits energy ; its existence is 134 THE THEORY a continued metastasis ; and it may be looked upon, says Graham, " as the probable primary source of the force ap- pearing in the phenomena of yitality." The distinction be- tween the two kinds of matter is, in fact, " that subsisting between the material of a mineral and the material of an organized mass." And yet minerals may exist in the colloidal state ; the hydrated peroxides of the aluminous class, for ex- ample, are colloids. Furthermore, the mineral forms of silicic acid deposited from water, such as flint, are found to have passed during the geological ages from the colloidal into the crystalline condition ; and, on the other hand, in the so-called blood-crystals of Funke, a soft and gelatinous albuminoid is seen to assume a crystalline contour. " Can any facts," asks Graham, " more strikingly illustrate the maxim, that in Na- ture there are no abrupt transitions, and that distinctions of class are never absolute ? " * The foregoing considerations render it evident that the manifestation of organic energy by matter is not a contrast to the kind of energy which is displayed by inorganic matter, and so far justify the supposition that it may be a question of chemical composition and intimate molecular constitution. Vitality would not then be a special principle, but a result, and would be explained ultimately by the operation of the so-called molecular forces. Coleridge's assertion, that the division of substances into living and dead, though psychologically ne- cessary, Avas of doubtful philosophical validity, would receive a support which its author could scarce have expected for it. Before granting any conclusion, it is desirable to examine into that which is generally deemed to constitute the spe- * A farther characteristic of colloids is their singular inertness in all ordinary chemical relations, though they have a compensating activity of their own in their penetrability ; they are permeable vrhen in mass, as water is, by the more highly diffusive class of substances, but they cut off entirely other colloidal substances that may be in solution. It is evident that our conception of solid matter must soon undergo considerable modification. (On Liquid Diffusion applied to Analysis. By T. Graham, F. R. S. Philo- sophical Transactions, 1862.) OF VITALITY. 135 cialty of life. Now, it is certain, when we consider the vast range of vitality from the simple life of a molecule or cell to the complex life of man, that valid objections may be made to any definition of life. If it be v/ide enough to comprise all forms, it will be too vague to have any value ; if narroAv enough to be exact, it will exclude the most lowly forms. The problem is to investigate the conditions of the manifesta- tion of life. A great fault in many attempted definitions has been the description of life as a resistance or complete con- trast to the rest of Nature, which was supposed to be con- tinually striving to destroy it. But the elements of organic matter arc not different from those of inorganic, whence they are derived, and to which they return ; and the chemical and mechanical forces of these elements cannot be suspended or removed within the organism. What is special is the manner of composition of the elements : there is a concurrence of manifold substances, and they are combined or grouped to- gether in a very complex way. Such union or grouping is, however, only a further advance upon, and by no means a contrast to, the kind of combination which is met with in in- organic bodies. Life is not a contrast to non-living Nature, but a further development of it. The more knowledge ad- vances, the more plainly is it shown that there are physical and chemical processes upon which life depends. Heat is produced by combustion in the organism as it is in the fire ; starch is converted into sugar there, as it is in the chemical laboratory ; urea, which is so constant a product of the body's chemistry, can be formed artificially by the chemist; and the process of excitation in a nerve, on the closure of a con- stant stream, appears to be analogous to the process of elec- trolysis in which hydrogen is given off' at the negative pole.* The peculiarity of life is the complexity of combination in so small a space, the intimate operation of many simultaneously- acting forces in the microcosm of the organic cell. Knowl- * A. von Bozold : Untersuchnnfreu ilber die electrischo Errcgung dcr Ncrvcn imd Muskeln. Leipzig, ISGl. 136 THE THEORY edge cannot pass the life-boundary, because there are not at present any means of follo^Ying the intimate changes which take place beyond it ; there is a world there into which the senses of man cannot yet enter. But, as each great advance of science has followed some invention by which the opera- tion of the senses has been extended, there can be little doubt that the important step toward a true science of life will be made with the discovery of a means of tracing the delicate processes of protoplasmic activity. Microscopic phys- ics and microscopic chemistry, nay, physics and chemistry of a delicacy beyond the reach of the powers of the highest microscope, are needed. So that it may well be that this gen- eration and generations to come will have passed to their everlasting rest before a discovery of the secret of vital ac- tivity is made. Before dealing with that which is considered to mark a second and great peculiarity of life, namely, its aim or plan, it will be well to illustrate the foregoing remarks from the phenomena of conscious vitality. It is, in truth, with the low- est form of vitality as it is with the lowest form of conscious vitality — with the human mind in the earliest stages of its evo- lution. A self-conservative impulse moves the most barbarous people to regard the operation of the external forces of Nature, and to adopt rude means to preserve life and to obtain comfort ; the savage avoids the current which would drive his frail ca- noe on the hungry breakers, and shelters his hut from the over- whelming fury of the storm ; he may be said to war with ]^a- ture for the maintenance of individual power, as the vital force of a cell may be said to war with the nature that imme- diately surrounds it. But it is obvious that man only struggles successfully with the physical forces by recognizing the laws of their action, and by accommodating his individual forces to physical laws ; it is victory by obedience. By conscious obedi- ence to the physical law, he appropriates, as it were, the force thereof, in the increase of his own power ; the idea is devel- oped in his mind as the correlate of the law or idea in ISTa- OF VITALITY. 137 ture ; in liis mental progress ISTature is undergoing develop- ment through him. By keeping in mind this analogy of the mental force the difficulty will be obviated, which there might seem to be in conceiving the organic cell as a result of physi- cal and chemical forces, and yet as resisting the action of these forces. Every act of so-called resistance on the part of the cell to the natural forces is really a phenomenon indi- cating the development of them; its life is not a contrast to non-living Nature, but a further complication of it. The fun- damental law of life is the same for its conscious and uncon- scious manifestations ; it is individuation by appropriation. And, however necessary it may seem to the individual, as a part of a whole looking at the rest, to represent the vital as in constant antagonism to the physical, such a conception does not faithfully express the condition of the whole regard- ed as a whole. A just conception of Nature as one harmoni- ous whole is plainly not antagonistic to the spirit of any in- vestigations which may tend to prove the dependence of life on physical and chemical processes. That which is commonly said to constitute the specialty of life is the maintenance of a certain definite plan ; and accord- ingly Coleridge, following Schelling, defined life as "the principle of individuation." Given the difi*erent kinds of force and of matter, and how, it is asked, is the pattern de- termined and worked out? As every individual is in life weaving out some pattern "on the roaring loom of time," though " what he weaves no weaver knows," so the lowest form of vitality manifests a definite energy, and is said to accomplish a definite plan. A crystal would go on increasing if suitable materials and the conditions of its growth were present, " but it has been provided that trees do not grow up into heaven." Life works according to an aim, said Aristotle. Admitting all this, we are not therefore called upon to admit a special contrast to the rest of Nature. Liebig compares the living body to a building which is constructed after a definite, preordained plan; but it is obvious that exactly in the same 138 THE THEORY. sense might the positive biologist say of the chemical atom, that it is constructed and displays energy according to a pre- ordained plan; or even of the crystal, that it works out a certain pattern, seeing that it cannot overstep the laws of its form. The plan is the law of the matter, and the law is not something outside the matter, but it is inherent in it. Organic matter, like the chemical element, has an activity given to it- self which it must display ; the law of causality is true of it as of inorganic matter ; and the organic effect, the so-called accomplishment of the plan, is the necessary result of a cer- tain molecular constitution and certain intimate combinations which exist in the organic molecule or cell or monad, or whatever else we choose to name the ultimate unit of life. The direct denial of a special vital force has been the natural reaction against that dogmatism which assumed a vital principle that Avas self-generating, did any thing it liked, and was not amenable to investigation. That any force should be self-generating in inexhaustible quantity is really an in- conceivable supposition. If the axiom, that force, like matter, is not capable of annihilation, be accepted, and we find, as we do, that organic bodies incorporate, or somehow cause to disappear, inorganic matter and force, and thereby themselves increas-e, it is an unavoidable conclusion that the organic matter and force must represent the converted inorganic matter and force. To suppose that the vital force was self- produced would be to suppose a disturbance of the equilib- rium of Nature, and it might not then be unreasonable to fear lest the earth, by the increase of its repulsion force, should break througli the hinges of gravitation and float off into space, or burst into fragments, as a planet between Mars and Jupiter is supposed at one time to have done.* * Science, in its view of life, seems to be following the course of develop- ment in Humboldfs mind. In his earlier writings he defined vital force as the unknown cause which prevents the elements from following their origi- nal attractive forces. (Aphorism, ex doct. Phys. Chem.Plant.) " Reflection and prolonged study," he says, in his "Aspects of Nature," "in the depart- ments of physiology and chemistry, liave deeply shaken my earlier belief in OF VITALITY. 139 TMien, however, it is said that a minute i)ortion of living matter converts inorganic matter into its own nature, and thus develops new organic matter which has the power of doing likewise, it is evident that a great and peculiar poten- tiality is assumed in the living molecule. AVhat power is it which transforms the matter and force ? Some who have ad- vocated the correlation of the vital force with the physical forces seem not to have given due attention to this question ; they have laid such great stress on the external force as to have fallen into an error almost as great as, though the oppo- site of, that of the advocates of a self-generating vital force. External circumstances are the necessary conditions of in- vrard activity, but the inward fact is the important condition — it is the determining condition, and, so far as we know yet, it can only he derived from a like living mother struct- ure. Nevertheless, even in that inherited potentiality there is not a contrast to that Avhich happens in the rest of Nature. When heat is converted into electricity, or any force into another, the change is not self-determined; the determining force lies in the molecules of the matter, in the so-called statical force, that which Aristotle in his division of causes names the material cause. And if it be objected that a little life is able to do such a great deal, the answer is that a like thing happens in fermentation. When a certain organic sub- stance makes the inorganic matter in contact with it become organic, it may be that it does so by a kind of infection or fermentation by which the molecular relations of its smallest particles are transferred to the particles of the inorganic just as in the inorganic world forces pass from matter to matter. But there are further considerations. Admitting that tlie vital transforming matter is at first derived from vital struct- peculiar so-called vital force." And again : " The difficulty of satisfactorily referring the vital phenomena of organism to physical and chemical laws depends chiefly (and almost in the same manner as the prediction of mete- orological processes in the atmosphere) on the complication of the phenom- ena, and on the great number of the simultaneously-acting forces, as well as the conditions of their activity." 140 THE THEORY nre, it is evident that tlie external force and matter trans- formed does in turn become transforming force — that is, vital. And if that takes place after the vital process lias once com- menced^ is it, it may be asked, extravagant to suppose that a similar transformation might at some period have commenced the process, and may even now be doing so ? The fact that in growth and development life is continually increasing, from a transformation of physical and chemical forces, is after all in favor of the presumption that it may at first have so origi- nated. And the advocate of this view may turn upon his opponent, and demand of him how he, with a due regard to the axiom that force is not self-generating, and to the fact that living matter does increase from the size of a little cell to the magnitude of a human body, accounts for the continual production of transforming power? A definite quantity only could have been derived from the mother structure, and that must have been exhausted at an early period of growth. The obvious refage of the vitalist is to the facts that it is impossi- ble now to evolve life artificially out of any combination of pliysical and chemical forces, and that such a transformation is never witnessed save under the conditions of vitality. Thus the argument stands. Meanwhile, those who do believe in the origination of life from non-living matter hope to succeed in artificially producing the upward transforma- tion, and may say reasonably enough that it is not to be ex- pected that such transformation should now take place as a regular process in Nature, except under conditions of vitality. Such a supposition is as unnecessary as it would be to assume that the savage must continue to rub together his sticks, after he has obtained the spark, in order to make the fire burn. What only is necessary is that the spark of fire, or the spark of life, once evolved, should be placed under suitable condi- tions, and it will then go on increasing. The minutest portion of living matter really now contains implicitly, as it were in a microcosm, the complexity of chemical and physical combina- tions and the conditions which were necessary for the first OF VITALITY. 141 production of life in the macrocosm, and it supplies these as the conditions of further vital transformations. In fact, Na- ture, having accomplished a result, does not need on each fu- ture occasion to go through the preliminary steps by which the result was first arrived at. And in this relation it is very interesting to observe how much use is made of the force supjdied by the destruction of certain organic matter in rais- ing other matter to a higher stage. It is supposed, for ex- ample, that urea is partly produced by the oxidation of an excess of so-called albuminous matters in the blood, without these having entered into the formation of tissue ; and the force thus supplied in the retrograde metamorphosis will be available, and probably is used, for the exaltation of other elements. It needs but little consideration to see that the living cell cannot supply all the force which is used in increasing and advancing life — in the multiplication and transformation of cells; heat and other external conditions are necessary, as being, so to speak, material for transformation. It is a mis- take, however, to say, as some have said, that heat and ex- ternal conditions determine the rate of growth. The rate of germination, for example, certainly varies according to exter- nal conditions, but the limits of variation are fixed by the inherent properties of the structure. The seeds of a begonia taken from the same pod will, as Mr. Paget has pointed out, germinate, some in a day, some at the end of- a year, and some at various intermediate times, even when they are all placed under the same external conditions. And the same author has pointed out other indications of self-dependent time-rates in the lower organisms. There are, in fact, inter- nal as w^ell as external conditions of growth, and the former are the more important, for they are really the determining conditions. It is with the organic cell and its conditions as it is with the individual and his circumstances ; the latter may greatly modify character, and are necessary for development, but the essential fact, which determines the limit of the modi- 142 THE THEORY fjing power of circumstances, is the nature implanted in the individual. It is easy to perceive how impossible it is, in the present state of science, to come to any positive conclusion with re- gard to the nature of the vital force. . All that can be said is, that advancing knowledge more and more clearly proves the dependence of life on physical and chemical processes, and tends to show that vital action does not contrast with the kind of action exhibited by inorganic Nature. Living matter displays, in fact, the energy of colloidal and the plan of crys- talloidal matter. When vital force undergoes resolution into inferior force, simultaneously with the decomposition of sub- stance, it is into heat, chemical force, and electricity, that we find it, as it were, unfolded; it is a natural conjecture, there- fore, that the conditions of the artificial production of vitality must be a high and complex chemistry to represent the stat- ical correlative, and some mode of repulsion force, as heat or electricity, or both, to represent the dj-namical correla- tive. It is certainly extremely unphilosophical in the present condition of knowledge to refuse to accept vitality as a si^ecial mode of manifestation of force ; the special character of its phenomena demand that, whatever its real nature may be, vital force should for the present be received as a distinct force on the same terms as chemical force or electrical force. The facts of observation, as well as a priori considerations, unquestionably demand also that it should be regarded as subject to the laws of the correlation and conservation of force. As, then, vital force is plainly by far the highest force in dignity, a small quantity of it will correspond in value to a much greater quantity of an inferior force ; one equivalent of vital force, in fact, will correspond to many equivalents of the lower forces. An immense amount of force is re- quired to raise matter from its elementary state to that con- dition in which it is described as organic ; and the upward transformation evidently only takes place through the inter- OF VITALITY. 143 mediate action of cliemical force. But vital force surpasses chemical force apparently in as great a degree as chemical force surpasses physical force. How great, then, must be its mechanical equivalent! Who can measure the power of a great idea? Armies fight in vain against it, and nations yield to its sway. What wonder that life was the last and highest development of Nature, and that it was produced only after the inferior forces had been long in existence ! "What ground, furthermore, it might be asked, have we for supposing that it is destined to be the last development of force ? Is it not possible that a still higher manifestation of force than that which we call vital may ultimately result from the complexity of forces and conditions which are now present on earth? The hypothesis of Laplace was, that in primeval times a large quantity of nebulous matter was spread through space. This nebulous matter was through gravitation aggregated into solid masses. Immense heat must have been thus produced, and this heat might then produce light, and develop electricity as it does now when acting on the thermo-electric plates. Electricity might appear again as heat or as light, or as chemical force, as it does in the de- composing cell of a voltaic battery. The correlation of these forces we are able to trace now, and it is not difficult to con- ceive how they mutually excited and affected one another in the primeval times when the earth was, as vre are told, without form and void. But there was a time when no life existed on the earth. So that as we can now obtain one force from another up to the point where life begins, when we are at fault, similarly considerable time elapsed in I^ature before vital force followed on the physical and chemical forces. Science may, then, claim that in its difficulty and delay it only reflects a corresponding difficulty in ]^ature. But there are other important considerations with regard to vitality. It does not follow, because we recognize a special vital manifestation, that there is but one kind thereof; it is in reality necessary to admit different degrees, if not different 144 THE THEORY kinds, of vitality. As with organic matter so with organic force, we trace an advance from the most simple and general to the most complex and special. The tissue of the simple protozoon is uniform and exhibits no trace of structure ; its active relations are equally simple. In the ascending scale of life continuous differentiation of tissue corresponds with increasing specialty and complexity of relation with the ex- ternal, until in man we observe the highest example of a unity of organism proceeding from manifold varieties of ele- ments, and of unity of action from the coordination of many forces. And as it is with the animal kingdom, so it is with the elementary structures which form it ; there is a scale of dignity, a hierarchy of tissues ; the lowest appear first, and are neces- sary steps for the evolution of the highest. All the force of ISTature could not develop a nerve-cell directly out of inor- ganic matter; and the cell of the Protococcus nivaUs, or the molecules of the Amoeba, could not, under any possible cir- cumstances, energize as nerve-force. Between the vitality of thought and the vitality of the fungus there is scarcely a comparison possible ; the former is dependent upon the widest and most complex, and at the same time the most intense and special relations with external Nature, while the latter exhibits only a few general and comparatively simple relations there- with. Between the relations of a nerve-cell and an epidermic cell with their surroundings, there is as much difference as there is between the relations of a Ehizopod and those of a Cephalopod with external Nature. And the relations of a nerve-cell with its surroundings are, it must be remembered, dependent on the maintenance of the relations of all the in- ferior elements of the body which intervene in the descending scale between it and the inorganic. Whatever, then, may be the fact in animal development, it is certain that transformation of species takes place in the structural elements. "When a tissue takes material from the blood, it does not merely aggregate, but it assimilates it — that is, it makes it of tlie same Hnd with itself. In develop- OF VITALITY. 145 iiicnt, a higher tissue constantly proceeds from a lower one, and demands the lower one as a necessary antecedent to its production ; it has thus, as external conditions, not only those which are general, but the intimate and special influ- ences of the tissue which is before it in the order of existence. In the latter are supplied the special and essential conditions for the exaltation and transpeciation of force and material. But all exaltation of force is, as it were, a concentration of it ; one equivalent of the higher force corresponds to many equivalents of the inferior force which has been transformed. Hence it is that the power of reproducing tissues or parts in animals is diminished much more by development than by growth ; and the law which describes the reparative power in each species of animal as being in an inverse ratio to its position in the scale of life, though not strictly proved, is yet true as a general proposition. If, now, the degree of dignity of an element represents a corresponding degree of vitality, it is obviously right to speak of the life of the blood, without any design of placing its life on the same level with that of nerve. In the decomposition of material and the correlative resolution of force which take place when the blood-cell returns to the inorganic state, there will be much less force liberated than when a nerve-cell un- dergoes the retrograde metamorphosis. As a great expendi- ture of force is needed to raise matter from the inorganic to the organic state, so a further greater expenditure is required to raise matter from a low organic to its highest organic con- dition. The nerve-cell is, so to say, the highest parasite which thus sucks up the life of the blood ; and, if the process of its decomposition were accurately observed, it would be found that all the force w^hich had been consumed by it in its upward transformation was given back to Nature in its down- ward metamorphosis. The retrograde metamorphosis of organic elements is con- stantly taking place as a part of the history of life. In the function of nerve-cell, a nerve-force is liberated which excites 146 THE THEORY muscular force, and is ultimately given back to external liga- ture as motion ; the coincident " waste " of substance is re- ceived into the blood, and ultimately also passes back to I^ature. It is probable, however, that this " waste " does not pass always directly out of the body, but that it may be first used as the nutriment of some lower element. Thus, as there seemed reason to believe that, in the economy of Na- ture, animal matter did not undergo the extreme retrograde metamorphosis into inorganic matter before being used as food by vegetables, so in the animal body the higher elements do not appear at once to undergo the extreme retrograde metamor- phosis, but are first used as the nutriment of lower organic element. How admirably does Nature thus economize in the body! Just as on a larger scale the carbonic acid exhaled by animals is taken up by vegetables, and a poison thus re- moved from the atmosphere in which the animal lives, so by one organic element of the body the blood is purified from the waste matter of a higher element which would be poison- ous to it. The parts impaired by activity, as all parts mast be, are repaired during rest in a condition of health. And it is very interesting to observe, as Mr. Paget has pointed out, that the organic processes of repair in each tissue are ad- justed to a certain time-rate, which is variable according to, but is not determined by, external conditions. The time-rate is determined by the implanted properties, and "for each unit of nutrition might be reckoned a unit of time." The periodicities of organic life appear to be prominent instances of the law ; and the rhythmic motions of the heart, or the motions of cilia, are, Mr. Paget supposes, due "to a method of nutrition in which the acting parts are, at certain peri- ods, raised with time-regulated progress to a state of instabil- ity of composition from which they then decline, and in their decline may change their shape and move with a definite velo- city, or (as nervous centres) may discharge nerve-force." * In * On the Chronometry of Life. By J. Pa^et, F. R. S. (Croonlan Lec- ture bcforo the Royal Society, 1857.) OF VITALITY. 147 this recognition of the chronomctry of organic processes, there is iinquestionahly great promise for tlic future ; for it is plain that the observance of time in tlio motions of organic molecules is as certain and universal, if not as exact, as that in the motions of heavenly bodies. Each organic process has its definite time-rate ; and each cell has its appointed pe- riod of life different for different kinds of cells. The exer- cise of its energy is the accomplishment of the life-task of the gland-cell of the stomach, and its existence ends therewith — it discharges its duty with its life ; but it is not so with other cells. It is not known, for example, how soon the blood-cell and other cells die. The blood-cell may be ephemeral, and after the manufacture of its material straightway perish, supplying in the products of its decomposition material for the coloring matters of the bile; or it may accomplish its function more than once, and live therefore for some time. Certain facts do, indeed, point to a short duration, as, for example, the de- struction of the nucleus in the blood-cell, the analogy of the cells of the stomach and milk-glands, and of the sebaceous and spermatic cells, and the great production of blood-cells ; but nothing positive is known, and the subject is one which awaits, and ought to receive, careful attention. Such, then, is the general process of life physiologically regarded. But there is nothing special in disease. Although the destructive cancerous mass seems at first sight to admit of no sort of comparison with the beneficial formation of a developing organ, yet the production is governed by laws of organic growth and activity. No new forces nor new laws appear in the organism under the circumstances which are de- scribed as disease. " 'Tis as natural to die as to be born,'' says Sir T. Browne ; and, if we choose to ac 3ept the doctrine of final cause, we must acknowledge that the disease w^hich leads to death is as natural, as much in the purpose of Nature, as the physiological processes which constitute health. An indi- vidual exists in certain relations with the external, and the harmonv which results from the maintenance of these rela- 148 THE THEORY tions is health, while a disturbance of them, whether from a cause in the organism or in the external circumstances, or partly in one and partly in the other, is discord or disease. The phenomena of morbid action may therefore, when prop- erly regarded, be serviceable as experiments illustrating the character and relations of vital action. As each cell has its appointed period of life, and each species of cell its natural degree of life, and as there are many cells and many kinds of cells in the human body, it is evident that disease will be more easily initiated in it than in an organism with less differentiation of tissue, and less com- plexity of structure. For the life of the organism is the sum of the life of its individual parts, and superiority of vitality signifies more numerous, special, and complex relations with the external. In the lowest organisms, where there is a similarity of structure, one part is independent of another, and dependent only on the maintenance of certain general and simple relations with the external ; there is, therefore, comparatively little liability to disturbance.* "When the parts are, however, unlike, and there is a definite subordination of them, so that the well-being of the highest structure is de- pendent on the well-being of all the structures which inter- vene in the descending scale between it and inorganic Nature, there is plainly abundant room for disturbance. As in the state, 80 in the organism, the vitality of the government flows from, and rests upon, the well-being of individuals. "When, from some of the many disturbing causes which initiate disease, a particular elementary constituent of the body is prevented from rising to the dignity of its specific constitution and energy, there will, if the disturbing cause * Goethe, after saying that every thing living is a collection of living, self-dependent beings, adds: "Je unvolkommner das GeschOpf ist, depto mehr sind diese Theile einander gleich oder ahnlich, und desto mehr gleichen sie dem Ganzen. Je volkommner das GeschOpf wird, desto nnShnlicher werden die Theile einander. Je ahnlicher die Theile einander sind, desto weniger sind sie einander suhordinirt. Die Subordination der Theile deutct aaf ein volkoaunncros GeschOpf." OF VITALITY. 149 has not been so serious as to destroy the life of the part, be a production of an element of a lower kind with a lower en- ergy ; and that is a diseased product. It is as if the substance of a polype were produced among the higher physiological elements of the human body, and went on increasing there without regard to relations with surrounding elements of tissue. There may be a production of foreign substance in larger quantity than that which should rightly be formed of the natural tissue, and a greater display of force, but both structure and energy are of a lower order. "What is gained in quantity is lost in quality, and the vitality is intrinsically less. Inflammation in a part is really the result of a degenera- tion of its vitality. "When a wound heals by the " first inten- tion," there is direct adhesion of its surfaces, and no inflam- mation, for the natural vitality of the part is maintained, and effects the repair. When slight inflammation occurs, the vi- tality of the part has undergone a certain dj.'ceneration, and material of an inferior order to the proper element of the part is produced ; this substiCnce binds the surfaces together, and it may in process of time, on the complete subsidence of in- flammation, and under the favorable conditions of surround- ing healthy tissue life, even rise to the condition of the proper structure. But the lymph does not appear to be thrown out with any special beneficial design ; it is the simple result of a deterioration of energy, is only a less degree of a positive evil. When greater inflammation takes place, or when the natural vitality of the part is feeble, there is a greater degen- eration, and material of a still lower kind, wbich is not even organizable under any circumstances, is produced. Pus is poured out, and ceases to appear with the restoration of the proper vitality of the tissue. If the inflammation is still greater, the degeneration passes into actual destruction of life, and mortification ensues. "When John Hunter, therefore, speaks, as he does, of Nature calling up the vital powers to produce suppuration, his words convey a false notion of what 150 THE THEORY really happens. The injury has so damaged the parts that the vital action cannot rise to its specific elevation ; an in- ferior kind of action is alone possible, which is really disease, and only so far beneficial as it proves that the life of the part has not been killed outright. As might be expected, there- fore, it is in exhausting diseases that inflammation most com- monly and easily occurs. How incorrect, then, is it to speak of inflammation as if it were a process specially provided for restoring the healthy life of parts ! When adhesive inflamma- tion is said to limit the suppuration of an abscess, its occur- rence is a result of diminishing mischief, and testifies to a less serious degeneration of vital force. How hard it is not to be blind when theories or wishes lead us ! "When adhesive in- flammation fixes a piece of strangulated gut to the side of the belly, so as happily to prevent the passage of fecal matter into the peritoneal cavity, it is sometimes said to be a wise and kindly provision of IsTature. What, then, shall be said of inflammation when it glues the gut to a hernial cavity, or manufactures a fibrous band which strangles the gut ? Is this also a wise and beneficial design ? That which is true of the material products of inflamma- tion is necessarily true of its force ; the heat, and pain, and rigors, the forces as well as the material, testify to a degenera- tion of vital force. The sort of stormy rage and demonstra- tive activity which characterize inflammation, though unques- tionably an exhibition of force, are not really an increased display of the proper vital force. Tlie latter has undergone a transformation from the quiet, self-contained activity of development into the unrestrained dissipation of a lower ac- tivity ; and, as regards the latter, it might be said that sev- eral monads of its matter, or volumes of its force, are equiva- lent only to one monad of matter or one volume of force of the former. Rigors, as the involuntary action of voluntary muscle, are a degradation of action witnessing to a molecular deterioration of vital conditions. Heat is a physical force which mnst have resulted from the retrograde metamorphosis OF VITALITY. 151 of vital force. The existence of pain, where rightly there should bo no sensation, testifies to a molecular deterioration of statical element and a correlative exhibition offeree. The increased action of inflammation in a part is, therefore, di- minished vital action. Perhaps it might once for all be stated, as a law of vital action, that the dignity of the force is in an inverse ratio to its volumetrical display. It is indeed with organic action as it is with mental action. The emo- tional man displays considerable force, and often produces great effects in the way of destruction, but his power is vast- ly inferior to that of the man who has developed cmotiona. force into the higher form of will-force, who has coordinated the passions into the calm, self-contained activity of definite productive aim. Surely creation always testifies to a much higher energy than destruction. The foregoing considerations unavoidably flow from a conception of vitality as correlate with other natural forces, and as subject to the law of the conservation of force. They obtain additional weight, however, from being in some ac- cordance with the important generalizations which one of the most philosophical physiologists of the present time has made with regard to morbid products. Yirchow has, as is well known, referred all morbid structures to physiological types, and maintains that there is no new structure produced in the organism by disease. The cancer-cell, the pus-cell, and all other disease-produced cells, have their patterns in the cells of healthy structure. The cells of tubercle corre- spond with the corpuscles of the lymphatic glands ; pus and colorless blood-corpuscles cannot be distinguished except by looking at the place whence they come ; the cells of cancer in bone " are the immediate descendants of the cells in bone ; " and certain colloid tumors have the structure of the umbilical cord. ""Where a new formation takes place, certain histolo- gical elements of the body must generally also cease to exist ; " and every kind of new formation is really, therefore, destruc- tive, and destroys something of what previously existed. The 152 THE THEORY connective tissue, with its equivalents, he describes as the common stock of germs of the body; from them morbid structures proceed by continuous development. " Heterolo- gous tissues have physiological types ; and there is no other kind of heterology in morbid structures than the abnormal manner in -which they arise as to place (heterotopia), timo (heterochronia), and quantity (heterometria)." * The conclusions with regard to vital force, which a con- sistent conception of it as a natural force seems to necessi- tate, will find extensive application in the various phenomena of disease. We have seen that if the resolution of the vital- ity of a single nerve-cell into a vitality of a lower kind be supposed — into that, for example, of polype substance — it would necessarily sufiice for the production of a whole polype, or perhaps of a multitude of polypes. In other words, one nervous unit, monad, or molecule, is the vital equivalent of many units, monads, or molecules of polype substance. How idle it is, then, to dispute, as some have done, as to whether epilepsy is increased vital action or diminished vital action, when there exists no clear conception of what is meant by the words ! l^o one can deny that there is great display of force in the convulsions of epilepsy, but is it increased vital force ? Is a man in convulsions a strong man ? for that is the real question. Does convulsion in a paralyzed limb indicate increased vital action of it ? When tetanus of a muscle is produced, as Weber showed it might be, by putting a loop of thread round its nerve and slowly and gradually tightening it, does the violent action of the muscle testify to increased vitality ? If it really does, then the mechanical tetanomotor of Heidenhain might, properly used, suflSce for the cure of every paralysis, and eflfect a com- plete renewal of life. In speaking of vital action, we may either consider the whole organism as individual, or we may consider the cell or organic monad as the individual. If we regard the organism * Cellular Pnthology. OF VITALITY. 153 D3 individiuil, then when general convulsions take place in it — that is, violent and aimless movements completely withdrawn from the control of the will, which should rightly coordinate them into definite action — it is simply to use words without meaning to say that the vital action of the individual is in- creased. There is not, then, individual action ; and the defi- nition of vitality is not applicable to the organism as a whole. The highest manifestation of individuality is in the conscious- ness of man, the so-called unity of the ego ; but, when the coordination of forces for a definite end is replaced by the convulsions of epilepsy, there is neither subjective nor ob- jective unity of action. Instead of that quiet will-force which expresses conscious unity, or that unconscious unity of or- ganic action which is manifest in sleep, there is the violent and incoherent exhibition of inferior force. Increased action is the result of a degeneration of the proper vital action. " A man in convulsions is not strong, though six men cannot hold him." Like considerations apply when the single cell is regarded as individual. In virtue of a certain chemical constitution and a certain definite arrangement of molecules, a cell ex- hibits energy as nerve-force. That special mode of energy is the definite result of a certain coordination of chemical com- binations and molecular relations ; and these are connoted in the individuality of the cell. "VYhen, however, in place of the definite process of statical attraction (nutrition) and dy- namical repulsion (energy), there takes place a largo demon- strative display of force — as general epileptic convulsions, being the sum of the action of the individual cells, prove there must — it is impossible to pronounce such force as of tlie same rank or kind as the proper energy of the cell. It is an inferior kind of power, and the certain indication of a de- generation of the statical correlative. It is the duty of a cell, 50 to speak, as of an individual, to live in certain relations with its surroundings — it is, indeed, its essence as an individ- ual cell of specific character ; and, when it is not so living, it 154 THE THEORY is really degenerating, losing its nature or kind, passing more or less quickly toward death. Its action is certainly not in- creased functional action. In truth, it would be as just to call the extravagant action of madness in an individual occu- pying a certain position in a system of government increased functional action, and to say that the government was stronger for his degenerate action. A state, again, would not be pow- erful, would not even exist, if each individual did as his pas- sions prompted, altogether regardless of his relations to others ; and it would certainly be a strange use of language to say then that the functional action of that individual was increased. The phenomena of conscious vitality might be used to illustrate the same principles. A passionate man is not strong-minded, nor do the ravings of insanity reveal mental vigor. A completely-fashioned will is the true mark of a strong mind. " A character," said JSTovalis, " is a completely- fashioned will." As in the order of natural development there has been an ascent from the physical and chemical forces to the aim- working vital force, and thence from the lowest vitality to the highest manifestation thereof, so in the course of mental development there is a progress through sensation, passion, emotion, reason, to the highest phase of mental force, a well-fashioned will. The rightly-developed mind, like the healthy cell, recognizes its relations to others ; self-feeling gives place to or expands into moral feeling, and in the will all the phases of consciousness are coordinated into calm, just, definite action. N'oise and fury surely indi- cate weakness ; they are the manifestation of inferior force — the tale of an idiot signifying nothing. The strongest force is quiet force, and the ravings of insanity, which might not unjustly be compared to the convulsions of epilepsy, do not evince mental power. May we not, then, already perceive, what advancing knowledge must ever render more clear, how the conscious mind of man blends in unity of development with the un- OF VITALITY. 155 conscious life of Nature ? As the revelation of Nature pro- ceeds in the progress of science, the idealism of Plato and the realism of Bacon will be found to harmonize as expres- sions of the same truths ; the generalizations of Humboldt and the poetical intuitions of Goethe may be looked upon as but difterent descriptions of the same facts. Idealism and real- ism blend and are extinguished in the intimate harmony be- tween the individual and Nature. How great, then, the igno- rance which fancies that poetry demands a rude age for its successful development ! How little, again, the insight which would make of science an ugly anatomy only ! After analysis comes synthesis ; and, beyond the practical realization of sci- ence in works which add to human comfort, there remains the ajsthetical embodiment of science. Art has now opening before it a field so wide that imagination cannot dare to limit it, for science must plainly attain to its highest development in the work of the future poet, who shall give to its reality a beautiful form. Goethe indicated the path, but he Avho shall accomplish it will be a greater than Goethe.* * Perhaps the tniest estimate of science, and the most remarkable prophecy with regard to it, is to be foand in that wonderful tale by Goethe, "Das Mahrchen," a tale which has been described, by one who has done most toward making Goethe known and understood in England, ''as the deepest poem of its sort in existence— ai? the only true prophecy emitted I'or who knows how many centuries.'" THE PHYSIOLOGY AND PATHOLOGY OF THE MIMB. By HENRY MAUDSLEY, M. i:>. rrice, cloth, $3.00, This is one of those works which mark the beginning of a new era in the study of mental science, and at the same time it is. conceded on all sides to be, in its practical portions, a most reliable guide for the diagnosis, descrip- tion, and treatment of insanity. "To effect a reconciliation between the Psycholoiry and the Pathology of the mind, or rather to construct a basis for both in a common science, is the aim of Dr. Maudsley's hook.'"— Lo?idan Saturday Heviezv, May 25, 1867. " The first chapter is devoted to the consideration of the causes of insanity. It would be well, we think, if this chapter were published in a separate form and scat- tered broadcast throughout the land. It is so full of sensible reflections and sound truths, that their wide dissemination could not but be of benefit to all thinking per- sons. In taking leave of Dr. Maudsley's volume, we desire again to express our gratification with the result of his labors, and to express the hope that he has not yet ceased his studies in the important field which he has selected. Our thanks are also due to the American publishers for the very handsome manner in which they have reprinted a work which is certain to do credit to a house already noted for its valu- able publications."— ^warier/y Journal of Psychological Medicine and Medical Juris- prudence. " Then follow chapters on the diagnosis, prognosis, and treatment of insanity, each characterized by the same bold and brilliant thought, the same charming style of composition, and the same sterling sense, that we have found all through. We lay down the book with admiration, and we commend it most earnestly to our readers, as a work of extraordinary merit and originality— one of those productions that are evolved only occasionally in the lapse ol years, and that serve to mark actual and very decided advances in knowledge and Bc\ence."—J!feiv York Medical Journal, January, 1868. " This work of Dr. Maudsley's is unquestionably one of the ablest and most im- portant, on the subjects of which it treats, that has ever appeared, and does infinite credit to his philosophical acumen and accurate observation. No one has more suc- cessfully exhibited the discordant results of metaphysical, physiological, and patho- logical studies of the mind, or demonstrated more satisfactorily the usclessness of ari exclusive method, or the pressing need of combined action, and of a more philo- Bophical mode of proceeding."— J/ec?ica/ Record, Xovember 15, 1867. "In the recital of the causes of insanity, as found in peculiarities of civilization, of religion, sex, condition, and particularly in the engrossing pursuit of wealth, this calm scientific work has the solemnity of a hundred sermons ; and, after going tiown into this exploration of the mysteries of our being, we shall come up into active life again chastened, thoughtful, and feeling, perhaps, as we never felt before, how fear- fully and wonderfully we are v[12i.^q.— Evening Gazette. " It is long since we read a scientific work of any kind, of which the raison d'etre was 80 thoroughly good and important, or which accomplished eo much toward the fulfilment of a most arduous and laborious task.'''— Lancet. "Dr. Maudsley's work, which has already become standard, we most urgently x'ocommend to the careful study of all those who are interested In the physiology and pathology of the hraln.''— Anthropological Revietc. THE ORIGIN OP CIVILIZATION; OR, THE PRIMITIVE CONDITION OF MAN By SIR JOHN LUBBOCK, Bart., M. P., F. E. S. 3SO rages. Illiastrated.. This interesting work is the fruit of many years' research by an accomplished naturalist, and one well trained in mod- ern scientific methods, into the mental, moral, and social con- dition of the lowest savage races. The want of a work of this kind had long been felt, and, as scientific methods are being more and more applied to questions of humanity, there has been increasing need of a careful and authentic work de- scribinor the conditions of those tribes of men who are lowest o in the scale of development. *' This interesting work — for it is intensely so in its aim, scope, and the ability of its author — treats of what the scientists denominate anthropology^ or the natural history of the human species ; the complete science of man, body and soul, including sex, temperament, race, civilization, etc." — Provi- dence Press. "A work which is most comprehensive in its aim, and most admirable in its execution. The patience and judgment bestowed on the book are every- where apparent ; the mere list of authorities quoted giving evidence of wide and impartial reading. The work, indeed, is not only a valuable one on ac- count of the opinions it expresses, but it is also most serviceable as a book of reference. It offers an able and exhaustive table of a vast array of facts, which no single student could well obtain for himself, and it has not been made the vehicle for any special pleading on the part of the author." — London AihencBum. " The book is no cursory and superficial review ; it goes to the very heart of the subject, and embodies the results of all the later investigations. It is replete with curious and quaint information presented in a compact, luminous, and entertaining form." — Albany Evening Journal. *' The treatment of the subject is eminently practical, dealing more with fact than theory, or perhaps it will be more just to say, dealing only with theory amply sustained by fact." — Detroit Free Press. " This interesting and valuable volume illustrates, to some extent, the way in which the modern scientific spirit manages to extract a considerable treasure from the chaff and refuse neglected or thrown aside by former in- quirers." — London Saturday Review. B. APPLETON & CO., Publishers. THE ORIGIN OF SPECIES, By CHARLES DARWIN. A new Americau edition of "The Origin of Species," later than the latest English edition, has just been published, with the author's most recent cor- rections and additions. In the whole history of the progress of knowledge there is no case so re- markable of a system of doctrines, at first generally condemned as false and absurd, coming into general acceptance in the scientific world in a single decade. From the following statements, the reader will infer tlic estimate that is now placed upon the man and his works by the highest authorities. "Pei'sonally and practically exercised in zoology, in minute anatomy, in geology ; a student of geographical distribution, not on maps and in museums only, but by long voyages and laborious collection ; having largely advanced each of these branches of science, and having spent many years in gathering and sifting materials for his present work, the store of accurately-registered facts upon which the author of the ' Origin of Species' is able to draw at will is prodigious." — Prof. T. H. IIuxley. " Far abler men than myself may confess that they have not that untiring patience in accumuhiting, and that wonderful skill in using, large masses of facts of the most varied kind — that wide and accurate physiological knowl- edge — that acuteness in devising, that skill in carrying out experiments, and that .admirable style of composition, at once clear, persuasive, and judicial, qualities which, in their harmonious combination, mark out Mr. Darwin as the man, perhaps of all men now living, best fitted for the great work he has undertaken and accomplished." — Alfred Kussell Wallace. In Germany these views are rapidly extending. Prof. Giekie, a distin- guished British geologist, attended the recent Congress of German Natural- ists and Physicians, at Innspruck, in which some eight hundred savants were present, and thus writes : "What specially struck me was the universal sway which the writings of Darwin now exercise over the German mind. You see it on every side, in private conversation, in printed papers, in all the many sections into which such a meeting as that at Innspruck divides. Darwin's name is often men- tioned, and always with the profoundest veneration. But even where no al- lusion is specially made to him, nay, even more markedly, where such allusion is absent, we see how thoroughly his doctrines have permeated the scientific mind, even in those departments of knowledge which might seem at firc>t sight to be farthest from natural history. 'You are still discussing in Eng- land,' said a German friend to me, ' whether or not the theory of Darwin can be true. We have got a long way beyond that here. His theory is now our common starting-point.' And, so far as my experience went, I found it to be so." 33. ^X>I>lL.ICXON & CO.. Fvi-blisliers. D. Appleton & Company''8 Pvhlications. LAY seemoj:^^, ADDEESSES, AND EEYIEWS, By THOMAS HEXRY HUXLEY. Cloth, 12mo. 390 pages. Price, $1.75 This is the latest and most popular of tlie works of this in- trepid and accomplished English thinker. The American edition of the work is the latest, and contains, in addition to the English edition, Professor Huxley's recent masterly address on " Spon- taneous Generation," delivered before the British Association for the Advancement of Science, of which he was president. The following is from an able article in the Independent : The " Lay Sermons, Addresses, and Reviews " is a book to be read by every one who Avould keep up with the advance of truth — as well by those who are hostile as those who are friendly to his conclusions. In it, scientific and philosophical topics are handled with consummate abil- ity. It is remarkable for purity of style and power of expression. No- where, in any modern work, is the advancement of the pursuit of that natural knowledge, which is of vital importance to bodily and mental well-being, so ably handled. Professor Huxley is undoubtedly the representative scientific man of the age. His reverence for the right and devotion to truth have estab- lished his leadership of modern scientific thought. He leads the beliefs and aspirations of the increasingly powerful body of the younger men of science. His ability for research is marvellous. There is possible no more equipoise of judgment than that to which he brings the phenomena of Nature. Besides, he is not a mere scientist. His is a popularized phi- losophy ; social questions have been treated by his pen in a manner most masterly. In his popular addresses, embracing the widest range of top- ics, he treads on ground with which he seems thoroughly familiar. There are those who hold the name of Professor Huxley as synony- mous with irreverence and atheism. Plato's was so held, and Gahleo's, and Descartes's, and Newton's, and Faraday's. There can be no greater mistake. No man has greater reverence for the Bible than Huxley. No one more acquaintance with the text of Scripture. He believes there is definite government of the universe ; that pleasures and pains are distrib- uted in accordance with law ; and that the certain proportion of evil woven up in the life even of worms will help the man who thinks to bear his own share with courage. In the estimate of Professor Huxley's future influence upon science, his youth and health form a large element. He has just passed his forty- fifth year. If God spare his life, truth can hardly fail to be the gainer from a mind that is stored with knowledge of the laws of the Creator's operations, and that has learned to love all beauty and hate all vileness of Nature and art. SFE^''GER8 SYSTEM OF PHILOSOPHY, THE PHILOSOPHY OF EVOLUTION. By HERBERT SPENCER. This great system of scientiflc thou.i^ht, the most ori^'inal and important men- tal undertaking of the age, to which Mr. Spencer has devoted his life, is now well advanced, the published volumes being: First Principles, The Principles of Bi- ology^ two volumes, and Tlie Principles of Psyclwlogy, vol. i., which will be shortly printed. This philosophical system differs from all its predecessors in being solidly based on the sciences of observation and induction ; in representing the order and course of Nature ; in bringing Nature and man, life, mind, and society, under one great law of action ; and in developing a method of thought which may serve for practical guidance in dealing with the affairs of life. That Mr. Spencer is the man for this great work will be evident from the following statements : " The only complete and systematic statement of the doctrine of Evolution with which I am acquainted is that contained in Mr. Herbert Spencer's ' System of Philosophy ; ' a work which should be carefully studied by all who desire to know whither scientific thought is tending."— T. n. Huxlet. " Of all our thinkers, he is the one who has formed to himself the largest new scheme of a systematic philosophy."— Prof. Masson. " If any individual influence is visibly encroaching on Mills in this country, it is bis." — Ibid. " Mr. Spencer is one of the most vigorous as well as boldest thinkers that English speculation has yet produced." — John Sttjart Mill. '' One of the acutest metaphysicians of modern times." — Ibid. " One of our deepest thinkers."— Dr. Joseph D. Hooker. It is questionable if any thinker of fi.ner calibre has appeared in our coun- try."— George Henry Lewes. "He alone, of all British thinkers, has organized a philosophy."— TJ/cZ. " He is as keen an analyst as is known in the history of philosophy ; I do not except either Aristotle or Kant."— George Kiplet. "If we were to give our own judgment, we should say that, since Newton, there has not in England been a philosopher of more remarkable speculative and systematizing talent than (in spite of some errors and some narrowness) Mr. Her- bert Spencer."— Zoftc?on Saturday Review. " We cannot refrain from offering our tribute of respect to one who, whether for the extent of his positive knowledge, or for the profundity of his speculative Insight, has already achieved a name second to none in the whole range of Eng- lish philosophy, and whose works will worthily sustain the credit of English thought in the present generation,"— Fes^/nzn^^^r Revieic. Works of Herbert Sjoencer published by D. Appleton <& Co. The JPMJosoj)hy of Herbert Spencer, FIRST PRINCIPLES; IN TWO FAMTS: l THE UNKNOWABLE. II LAWS OF THE KNOWABLE, In one Volume. 518 pages. "Mr. Spencer has earned an eminent and commanding position as a metaphysioian, ftui his ability, earnestness, and profundity, are in none of his former volimies so oon- Bp««uous as in this. There is not a crude thought, a flippant fling, or an irreverent in- 6in.iation in this book, notwithstanding that it has something of the character of a daring and determined raid upon the old philosophies." — Chicago Journal. " This volume, treating of First Principles, like all Mr. Spencer''s •writings that have fallen imder our observation, is distinguished for clearness, earnestness, candor, and that originality and fearlessness which ever mark the true philosophical spirit. Hia treatment of theological opinions is reverent and respectful, and his suggestions and arguments are such as to deserve, as they will compel, the earnest attention of all thoughtful students of first truths. Agreeing with Hamilton and Mansel in the gene- ral, on the unknowableness of the unconditioned, he nevertheless holds that their being ia in a form asserted by consciousness." — Christian Advocate. '• The literary world has seen but few such authors as Kerbert Spencer. There hava been metaphysical writers in the same exalted sphere who before him have attempted to reduce the laws of nature to a rational system. But in the highest realm of philo- Bophical investigation he stands head and shoulders above his predecessors ; not perhaps purely by force of superior intellect, but partly owing to the greater aid which the light of modern science has afi'orded him in the prosecution of his difficult task."— Boston Bulletin. "Mr. Spencer is achieving an enviable distinction by his contributions to the coun- try's literature ; bis system of philosophy is destined to become a work of no small renown. Its appearance at this time is an evidence that oiu* people are not all absorbed la war and its tragic events."— <97a'o State Journal. " Mr. Spencer's works will undoubtedly receive in this country the attention thoy nimt. There is a broad liberality of tone throughout which will recommend them to ihlnking, mquiring Americans. Whether, as is asserted, he has established a new sya- tsm of philosoBhy, and if so, whether that system is better than all other systems, ia 70t to bo decided ; but that his bold and vigorous thought will add something valuabl* fad permanent to human knowledge is undeniable." — Utica Herald. "Herbert Spencer is the foremost among living thinkers. If lees erudite thai Hamilton, ho is quite as original, and Is mora comprehens'vo and catholic than Mas BcL"— rniversalul). Works publkJied bu R Applcton « Interest of a romance, so startlins are the descriptions and elucidations. " One of the most accomplished Writers of the Age." HISTORY OF THE EISE AKD INFLUENCE OF THE SPIRIT OF RATIONALISM IN EUROPE. By -W. E. H. LECIvY. IVI. A. 2 Vols, small 8vo. Cloth, $4. [From the Eclinlurgh Eecieic] " "We open&d these volumes, never having heard the name of their author, and entirely Ignorant of his pretensions to a place in English literature. "Wo closed them with the conviction that Mr. Lecky is one of the most accomplished writers and one of the most ingenious thinkers of the time, and that his book deserves the highest commendation we can bestow upon it. Indeed, it has seldom been our good fortune to take up an essay by an unknown, and we presume, a young author, so remarkable for the purity and elegance of its style, so replete -with varied erudition, appropriately introduced to enliven argument, or so distinguished for broad and dispassionate views. ****** This book well deserves to be universally read and carefully studied, for if the eye is dazzled at first by the bril- liancy of the fervor, the mind is interested and occupied by the subtlety and per- Bpicuity of a thousand observations which escape notice on a first perusal. In a word, we hope to see this work take its place among the best literary productions of the age, and we doubt not that it will powerfully conduce to the ultimate tri- umph of that cause to which it is devoted." D. APPLETON & CO., Publishers, 80, 82 & 94 Gbakd Street, New Youk. D. APPLET ON et CO:S PUBLICATIONS THE PHYSIOLOGY OF MAN; DESIGNED TO EEPEESENT THE EXISTING STATE OF PHYSIOLOGICAL SCIENOB, AS APPLIED TO THE FUNCTIONS OF THE HUMAN BODY. By ^TJSTIN injL,IN"T, Jr., l^t. 33. Alimentation; Digestion; Absorption; Lympli and Ohyl©. 1 volume, 8vo. Cloth. Price, $4.50. THE FIRST VOLUME OF THE SERIES BY CONTAINING Introduction; The Blood; The Circnlation; Eespiration. 1 volume, 8vo. Cloth. Price, S4.50. " Profcsf5or Flint is engaged in the preparation of an extended work on liuman physiology, in which he professes to consider all the subjects usually regarded as belonging to that department of phys- ical science. The work will be divided into separate and distinct parts, but the several volumes in which it is to be published will form a connected series." — Providence Journal. It is free from technicalities and purely professional terms, and instead of only being adapted to the use of the medical faculty, will be found of interest to the general reader who desires clear and concise information on the subject of man physical." — Eoenmg Post. " Digestion is too little understood, indigestion too extensively suffered, to render this a work of supererogation. Stomachs will have their revenge, sooner or later, if Nature's laws are infringed upon through ignorance or stubbornness, and it is well that all should un- derstand how the penalty for 'high living' is assessed." — Chicago Evening Journal. "A year has elapsed since Dr. Flint published the first part of bis great work upon human physiology. It was an admirable treatise —distinct in itself — exhausting the special subjects upon which it vr ca tod . ' ' — Ph iladelph i^ Inq uirer. *'A BOOK WHICH IS A3 READABLE AS A NOVEL: HISTORY OF EUEOPEAN MORALS, Fro^n Atigustus to Charlemagne, By W. E. n. LECXY, M. A. 2 vols., 8vo. 500 pages each. Price, $0.00. CONTENTS : The Utilitarian School— Objections to the School— Consequence of actini' on Utilitarian Principles— Utilitarian Sanctions— Intuitive School— Alleged Diversities of Moral Judgment— Each of the Two Schools of Morals relared to the General Condition of Society— The Order in which Moral Feelings are developed. THE PAGAN EMPIRE. Stoicism— Growth of a Gentler and more Cosmopolitan Spirit In Rome- Rise of Eclectic Moralists— The People still very corrupt— Causes of the Corruption— Effects of Stoicism on the Corruption of Society— Passion for Oriental Religiona—Neoplatonism. THE CONVERSION OP ROME. Examination of the Theory which ascribes part of the Teaching of the Hated Pagan Moralists to Christian Influence— Theory whicli attributes the Conversion of the Empire to the Evidence of Miracles— The Persecution the Church underwent not of a Nature to crush it— History of the Persecutions. FROM CONSTANTINE TO CHARLEMAGNE. First Consequence of Christianity, a New Sense of the Sanctity of Hu- man Life— The Second Consequence of Christianity, to teach Lniverpal Brotherhood— Two Qualifications of our Admiration of the Charity of the Church— The Growth of Asceticism— The Saints of the Desert— Decline ol the Civic Virtues— General Moral Condition of the Byzantine Empire— Dis- tinctive Excellences of the Ascetic Period— Monachism— Relation of Mona- chism to the Intellectual Virtues- The Monasteries the Receptacles of Learn in 2;— Moral Condition of Western Europe— Growth of a Military and Aristocratic Spirit— Consecration of Secular Rank. THE POSITION OF WOMEN. The Courtesans— Roman Public Opinion much purer— Christian Influ- ence—Relation of Christianity to the Female Virtues. D. APPLETCN & CO., Publishers, 90, 92 & 94 Grand St., New York. Bent free by mail to any address In th^ United States on receipt of tJu pnc4 THE N"KTV AMERICAN CYCLOFiEOIA D. APPLETON & CO., 90, 92 & 94 GKAND ST., HEW YOEK. HATE NOW UEADT THE NEW AMERICAN CYCLOPAEDIA, A POPULAR DICTIONARY OF GMERAL KNOWLEDGE. EDITED BY GEORGE RIPLEY and CHARLES A. DANA, AIDED BY A ICiimcrous Select Corps of Writers In all Bruuchcs of Solenee^ Art* and Literature, TN 16 L^Ti&E VOLXJiMES, 8vo, ToO double-column Pa^es in each Yolume. From the New York Times. ** It ia a work written by Americana for Americans. It proffers them tho knowledge they most require, selected and arranged by those who are compe tent to the task, because they themselves had experienced the want they now endeavor to supply. It is minute on points of general interest, and condensed in those of more partial application. Its information is the latest extant, and In advance of any other book of reference in the world. Tho best talent in tha country has been engaged in its production." PRICE OE THE WORK : In Extra Cloth, per vol., $5 00 In Library Leather, per vol., 6 00 In Half Turkey Morocco, black, per vol., 6 50 In Half Eussla, extra gilt, per vol., 7 50 In Full Morocco, antique, gilt edges, per vol., 9 00 (n Full Kussia, 9 00 Tho price of the work will, for the present, remain as above, but if them shall be any great advance in paper and material tho price must be increased To preve.it disappointment, orders should be at once forwarded to the publish- ers or to the agents of the work in different parts of the country. To those who have not already Subscribed for the Work Many persons have omitted to subscribe for the "Work during its progresi through the Press, owing to an unwillingness to subscribe for an incomplew *rorlt. They may now obtain complete sets in any of the above Stylos. D. APPLETON & CO., Publishers, 90, 92 k 94 Grand Street, New York. 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