V LIBRARY UNIVERSITY OF CALIFORNIA SAN DIEGO Date Due f^.i':/ 1 ft 1Q71 ly/ ! W AK 1 1 APR 2 91971 MAY fi if iw/ f RFC'D iNAP ^ 8 RtC'D \\\hi 1 ^ iQ7n Ml iW SEP 7 1988 SEP 13 RHTO .•\ ' , "• >o 3985* Scr ] REC'D Qf- 2 . -i992 Hr- , ! ^K'O « CAT. NO. 23 2 33 PRINT E^^ IN U.S.A. 1 DATE DUE COfiTIOUfD mSkhMH % lirrawer «ilir DEMCO NO. 38 -298 DIFFERENCES - IN THE NERVOUS ORGANISATION OF MAN AND WOMAN PHYSIOLOGICAL AND PATHOLOGICAL BY HARRY CAMPBELL M.D., B.S. (LOND.) MEMBER OF THE KOYAL COLLEGE OF PHYSICIANS ; SENIOR ASSISTANT PHYSICIAN AND PATHOLOGIST TO THE NORTH-WEST LONDON HOSPITAL. LONDON H. K. LEWIS, 136 GOWER STREET 1891 PREFACE. I HAVE attempted in this work to set forth the main differences — physiological and pathological — between the nervous organisations of man and woman. The patholo- gical differences have been the chief subject of my inquiry, but to the better understanding of these it has been necessary to consider also the physiological differences, and this has led me somewhat far afield. I have had to go back to the very beginnings of organic evolution — to seek to discover how and why the sexes became separate, and to trace their subsequent deviation from one another ; to examine, in short, into the whole question of the origin of sexual reproduction. And if it be objected that, follow- ing these lines, I have introduced much that is apparently foreign to my subject, I would urge that it is impossible to study any question from too many points of view, and that the wider our survey, the more thorough our know- ledge and the deeper our insight are likely to be in the end. The " Evolution of Sex " occupies Part I., and as this involved a critical exposition of Weismann's theory of Heredity, with particular reference to the inheritability of acquired characters, it is necessarily long. Apart, how- vi PREFACE. ever, from the fact tliat a clear understanding on this head is essential to accurate conclusions as to the way in which man and woman came to differ in the past, and are likely to diverge still further from, or approach nearer to one another, in the future, the question of the inheritability of acquired characters is the most important pathological question of the day, and one that has not yet received from the pathologist the attention it demands. I have therefore felt justified in discussing it at some length, and I may here state that while I have regarded the question as still open, I yet, on the whole, decidedly incline to the view that characters acquired by the soma — the body — are not inherited. Part II. is chiefly occupied with the pathological applica- tion of the conclusions arrived at in Part I., though a considerable space is devoted to the subject of the menstrual rhythm, which must ever remain one of absorbing interest to the physician. Part III. treats of Psycho-physiology, some knowledge of which is necessary to the inquiry I have undertaken. The chief portion of this section is concerned with the will and its disorders, from the psycho-physiological point of view, a subject of much practical importance, inasmuch as the will plays a large part in the phenomena of disease. And at this point I feel I owe some apology to the professed psychologist for having ventured into those obscure regions which are peculiarly his own. Here, however, as elsewhere throughout the work, I have thought proper to advance my own views on doubtful questions. In dealing with matters of certainty a writer has only one course open to him — to PREFACE. vii state the ascertained facts ; but where all or much is specu- lation, he should obtain sufficient mastery of the questions in dispute to be able to criticise the opinions of others regarding them, and to advance, it may be, views of his own ; for even though these be wrong, they may stimulate thought and let in some unexpected light by which others may profit. In short, I conceive the duty of a writer on a subject such as the present is to be as little as possible a mere compiler, and as much as possible an independent thinker : to merely repeat, and blindly accept the opinions of others can do nothing to further knowledge, and is, moreover, a task dreary alike to author and to reader, I have not considered the element of Eace. Certain nervous differences between the sexes are probably more accentuated in some races than in others. While, for instance, women are, as a class, more emotional than men, it is possible that the men of primitive peoples are more emotional than the women of civilised communities. My remarks, in so far as they apply to people of the present age, must be taken to refer to those with whom I have been brought into personal contact, and these are chiefly the inhabitants of the British Isles. But while race must modify the differences of the sexes as regards nervous organisation, its influence is confined chiefly, I believe, to superficial characters, the fundamental points of distinction obtaining all over the world. Every woman, of whatsoever colour or nationality, has probably a greater immunity than tlie man from gross lesions of the nervous system, and a greater tendency to recover from nervous diseases. Again, it is almost certain that all the viii PREFACE. world over, the woman is apt to suffer from certain nervous symptoms at the climacteric: and so, too, in regard to many other particulars. I do not by any means claim to have exhausted my subject in this work. While writing I have found it broaden out in all directions — new lines of inquiry have continually suggested themselves, many of which have had to be abandoned owing to the bulk to which the work had already attained. My purpose has been rather to point the way — to indicate a method of investigating a subject than which there is nothing more interesting in all the wide field of medicine. H. C. London, July 1891. CONTENTS. PART I. THE EVOLUTION OF SEX. CHAP. PAGE I. THE PHILOSOPHY OF SEXUAL KEPRODUCTION ... 3 II. .THE , EVENTS IMMEDIATELY PRECEDING AND FOLLOWING UPON THE UNION OF THE SEX CELLS — EXPLANATION OF HEREDITY 18 III. SEPARATION OF THE SEXES 28 IV. SECONDARY SEXUAL CHARACTERS 32 V. THE EVOLUTION OP THE SEXUAL INSTINCT . . . -35. VI. THE BEARING OP SEXUAL SELECTION ON THE EVOLUTION OF THE SECONDARY SEXUAL CHARACTERS . . . 40 VII. THE BEARING OF NATURAL SELECTION ON THE EVOLUTION OP SECONDARY SEXUAL CHARACTERS . . . . 50 VIII. INFLUENCE OF THE ENVIRONMENT ON STRUCTURE— ENVI- RONMENTAL MOULDINGS 57 IX. THE INHERITABILITY OP ENVIRONMENTAL MOULDINGS . 68 X. PART PLAYED BY THE ENVIRONMENT INDEPENDENTLY OF SELECTION IN RENDERING THE SEXES UNLIKE . . 82 XI. THE VIEWS OF GEDDES AND THOMSON .... 97 PART II. CHIEFLY CONCERNED WITH THE PATHOLOGICAL APPLICATION OF CONCLUSIONS ARRIVED AT IN PART I. I. GEDDES AND THOMSON'S VIEWS APPLIED TO MAN . -US II. GEDDES AND THOMSON'S VIEWS PATHOLOGICALLY APPLIED II9 III. THE COMPARATIVE LIABILITY OF MAN AND WOMAN TO GROSS LESIONS OF THE NERVOUS SYSTEM . . . n2 X CONTENTS. CHAP. PAGE IV. THE RELATIVE FREQUENCY OP THE MORE IMPORTANT FUNCTIONAL NERVOUS DISORDERS IN THE TWO SEXES . I4I V. THE INFLUENCE OP SEX ON PROGNOSIS IN. INSANITY . . I46 VI. WOMAN AN UNDEVELOPED MAN— NERVOUS DIFFERENCES BETWEEN THE BOY AND THE GIRL— MENTAL CHARAC- TERISTICS OF THE CHILD — MENTAL RESEMBLANCES BETWEEN THE CHILD AND THE SAVAGE . . . - I S3 VII. WOMAN AN UNDEVELOPED MAN (continued) — MENTAL RE- SEMBLANCES BETWEEN THE WOMAN AND THE CHILD . 16I VIII. WOMAN AN UNDEVELOPED MAN {continued) — PATHOLOGICAL APPLICATION OF FOREGOING CONCLUSIONS . . . 165 IX. WOMAN AN UNDEVELOPED MAN (continued) — INTELLECTUAL CAPACITY OF MAN AND WOMAN COMPARED — RATE OF MENTAL EVOLUTION IN THE TWO SEXES — MENTAL CON- DITION OF THE WOMAN AFTER THE CLIMACTERIC . . 171 X. EGOISM OF THE MAN AND ITS PATHOLOGICAL EFFECTS . 177 XI, FURTHER PATHOLOGICAL EFFECTS OF THE EGOISM OP THE MAN 185 XII. THE FACULTY OP PERCEPTION IN MAN AND WOMAN COM- PARED — OTHER CONSIDERATIONS . . .' . . . I9I XIII. SEXUAL INSTINCT IN MAN AND WOMAN COMPARED . . I99 XIV. INFLUENCE OF SEX ON SUICIDE — STATISTICS, CAUSES, MEANS 216 XV. THE COMPARATIVE NERVOUS PLASTICITY OF THE SEXES . 222 XVI. THE RELATIVE CLANNISHNESS OP MEN AND WOMEN . . 236 XVII. THE MONTHLY RHYTHM 24I XVIII. THE MONTHLY RHYTHM (continued) — PUBERTY — THE CLIMAC- TERIC—PREGNANCY — LACTATION 251 XIX. THE ANTE-PUBERTAL AND POST-CLIMACTERIC MENSTRUAL RHYTHMS 257 XX. IS THE MENSTRUAL RHYTHM PECULIAR TO THE FEMALE SEX ? 270 PART III. PSYCHO-PHYSIOLOGICAL. I. THE FEELINGS — THE INTELLECT 277 II. THE PRIMORDIAL UNIT OF CONSCIOUSNESS— THE COMPOUND- ING OF THIS INTO SENSATIONS — AND OP SENSATIONS INTO PERCEPTIONS AND CONCEPTIONS— THE COMPARATIVE INTELLECTUALITY OF THE VARIOUS SENSATIONS . . 286 ,Jv CONTENTS. xi CHAP. PAGE ; III. THE EMOTIONS 295 } IV. INFLUENCE OF THE FEELINGS ON THE THOUGHTS — PLEA- i SURABLE AND PAINFUL FEELINGS 304 V. THE FEELINGS CONSIDERED AS ACTIVE FORCES— THE PHYSICAL SUBSTRATUM OF CONSCIOUSNESS . . . 309 VI. THE FEELINGS AS ACTIVE FORCES (conthi lied)— SIMPLE MENTO-MOTOR ACTIONS 316 i> VII. THE INFLUENCE OF THE PEELINGS UPON Till'; BODY {C0»- i tinned) — COMPOUND MENTO-MOTOR ACTION . . . 326 VIII. THE FEELINGS AS ACTIVE FORCES (continued) — COMVOVSB MENTO-MOTOR ACTION 339 IX. VARIETIES OF WEAK WILL — THAT FORM IN WHICH COM- POUND MENTO-MOTOR ACTION APPROXIMATES TO SIMPLE MENTO-MOTOR ACTION 349 X. VARIETIES OP WEAK WILL (continued) — VACILLATION . 359 XI. VARIETIES OP WEAK WILL {continued) — FASCINATION . 363 XII. THE STRENGTHENING OP TH I-: WILL- -THE WILL AS A THERAPEUTIC AGENT 36S PAET I. THE EVOLUTION OF SEX. CHAPTEE I. THE PHILOSOPHY OF SEXUAL REPRODUCTION. General Rcmarhs on Sexual Reproduction. — Among cer- tain vegetable organisms almost every cell in the body is capable of reproducing the entire individual, and there are not wanting those who believe {e.g. Spencer, Niigeli) that in all multicellular organisms, animal as well as vegetable, every cell possesses this power in a greater or less degree. Be this as it may, in animal organisms only a limited number of cells is endowed with the full reproductive potentiality, certain cells being specially set apart for repro- ductive purposes. It occasionally happens that a single such cell is sufticient for reproduction (parthenogenesis), but, as a rule, two of them must co-operate : a cell derived from one organism unites with a cell derived from another, and from the blended mass the young embryo is developed. This is called " sexual " reproduction. There are, as we shall presently see, good reasons for concluding that the main purpose of sexual reproduction (in the metazoa) is this union of cells derived from different organisms. Even in the case of hermaphrodites, where both the uniting reproductive cells are derived from the same organism, cross fertilisation seems to be tlie rule. Sexual reproduction occurs among both ( i ) unicellular and (2) multicellular organisms. Among the latter the reproduc- tive cells may be formed, a, independently of any specialised organ ; or, h, from a tissue specialised for the purpose. 4 THE EYOLUTION OF SEX. [part i. 1. Sexual reproduction in unicellular organisms. — This may be dismissed witli a word. Sexual reproduction is at any rate pre-shadowed by the occasional behaviour of uni- cellular organisms. Thus among the ciliated infusoria two individuals frequently unite, and such union, or ' conjuga- tion,' has been shown by E. Maupas,' to be necessary to the continuation of the species. Without the occasional con- jugation of individuals not closely related, reproduction, which for the most part takes place by simple division, comes to a standstill, the cells dwindle and degenerate, "until at last we get shapeless abortions incapable of living and reproducing themselves." But after conjugation there is renewed protoplasmic activity, and among many of the protozoa at least, the blended mass may be observed to break up into a number of new beings, reminding one of the segmentation of the ovum. In the one case the cells re- suiting from the conjugation separate, and form independent individuals ; in the other, they remain together, and form the component cells of a single individual. The multicellular organism doubtless originated from the unicellular organism, by the cells resulting from the conjugation of individuals of the latter class remaining together instead of separating. The multicellularity thus attained probably conferred some benefit upon the individual, and was fixed by natural selec- tion. Even at the present day the link between protozoa and metazoa may be recognised in the form of loose colonies of cells. 2. Sexual reproduction in multicellular organisms. — a. The reproductive cells derived from non-specialised tissues. In the loose colonies of cells just alluded to as bridging over the gulf between the unicellular and the mul- ticellular organism, there are indications of special repro- ductive cells, but they are manifestly not formed from any specialised tissue. We have the first indication of distinct tissues in the sponges, the body in these consisting of an outer, middle, and inner layer, and the reproductive cells 1 Comptes Rendus, i886, 1887. "Archives de Zoologie Experimentale," 1888. PART I.] THE EVOLUTION OF SEX. being formed from any portion of the middle layer indiffe- rently : that is, there is no specialised reproductive organ, I. The reproductive cells derived from specialised tissues. In the common fresh-water hydra, and in practically all the higher organisms, the reprodvictive cells are similarly formed from the middle layer of the body. Here, however, for the first time as we ascend the scale, we find them no longer formed indifferently from any part of this layer, but from special reproductive organs, termed ovaries and testes, de- veloped in it. Fig. I. The Two Kinds of Sex Cells and their Evolution. — Among unicellular organisms the conjugating cells are, to all appearances, alike ; but among the multicellular, they are dimorphic. One class of cells, called ova, are compara- tively large, sluggish, and well nourished ; the other are smaller and more active, and are called spermatozoa. A distinct difference between the two cells which unite sexually may be detected even in the most primitive multicellular organisms — e.g., the sponges, and this differ- ence increases as the scale is ascended. The gradually increasing dimorphism of the reproduc- tive cells is illustrated in the accompanying figure. Starting with the simple am^-.:::::..- germ plasm. This constitutes the es '^ sential act of fertilisation : the first segmentation nucleus contains the potentialities of the new being. The Initial IStxujc of Development. — With each division of the impregnated ovum, the first segmentation nucleuf divides, and hence every cell of the embryo is derived from it. It is true that the body-protoplasm shares in the segmentation ; but the fact that in many animals only a small part does so, the greater portion fulfilling the more or less mechanical function of providing nourishment for the new being, and the further fact that the more specialised a definite part of the body becomes towards this end the less is the tendency of that part to segment,^ point to the con- ^ When the yolk material is small in quantity, as in mammals, it is dis- tributed equally throughout the entire body-plasm, and in such cases the ovum undergoes complete segmentation. When, however, the yolk is THE EVOLUTION OF SEX. [part I. Fig. 6. a elusion that the young embryo is essentially developed from the first segmentation nucleus. It is important to note that the first segmentation nucleus divides in such wise that each half contains plasm derived from both parents. Thus Fig. 6 a represents a segmentation nucleus before, and Fig. 6 h after, its primary division. In a the shaded part, /, is that portion of the nucleus which is derived from the father ; the unshaded part, m, that which is derived from the mother. In h the nucleus has so divided that each half is made up of a paternal and maternal portion, and each subsequent division takes place in a similar way. Every cell in the body may thus in a measure be regarded as a conjugated cell, and as, therefore, a mixture of differing tendencies. Hoio the Reproductive Mements come ly their Structure. — •• The two great problems of heredity are involved in the questions we have now to consider : ( i ) How do the repro- ductive elements come by their structure? (2) How, possess- accumulated in some parts more than in others, such parts show a diminished tendency to segment. Thus, in the eggs of birds (Fig. I.), the Fig. I. Fig. II.. Fig. III. bulk of the body-plasm is laden with yolk granules, only a small part round the nucleus being devoid of them, and it is this alone which shares in segmentation. When the yolk is diffused throughout the entire body, but accumu- lated more in one half than the other, as in the ovum of the frog (Fig. II. ) then that half in which it is most densely packed undergoes least segmentation. When, as in the crustaceans and insects, the yolk is concentrated round the centre of the egg (Fig. III.), this part takes no share in segmentation, which is confined to the peripheral portions. PART 1.] THE EVOLUTION OF SEX. 21 ing such a structure, are they able to develop into the mean likeness of the parent organisms ? ( i ) In regard to the former question there are two chief theories. The one assumes that the reproductive cells are formed from gemmules which are given off from all the different parts of the body, so that each part is individually represented in the reproductive cell. This is Darwin's doctrine of pangenesis, and has been variously modified since his time. The other is the theory of the continuity of germ-plasm, and its chief and most philosophical exponent is Weismann. This must now be considered. Hitherto the assumption has been that the soma^ possesses the power of generating the reproductive cells de novo. Weismann contends, however, that the reproductive cells (or more accurately the essentially reproductive portions of them) are derived — not from the soma, but from a portion of the original fertilised ovum which has remained undeveloped. He holds that only a part of the fertilised ovum develops into the new being or soma, the rest remaining in static quo, and constituting so much ' germ-plasm ' to form the essential material of future ova and spermatozoa. In each develop- ment a portion of the specific germ-plasm which the parental ovum contains, is not used up in the formation of the offspring, but is reserved unchanged to form the germ cells of the following generation. In some organisms the cells forming the reproductive organs are differentiated at the very beginning of segmentation, and there may then be said to be a direct continuity of reproductive cells ; but in the vast majority of cases they are not set aside until a comparatively late period in development, sometimes not till the very end ; and although in such cases a continuous chain of cells unites them with the original ovum-cell, yet there cannot strictly be said to be a continuity of repro- ductive cells, for each cell in the line of ancestry is not purely reproductive, since every time it divides it gives 1 Soma = body, or the developed individual, as distinguished from the un- developed reproductive material, or 'germ-plasm,' which, in Weismann's view, is handed on from generation to generation.. 22 THE EVOLUTION OF SEX. [part i. off a somatic cell also.^ Weismann, therefore, prefers to speak of the continuity of germ-plasm rather than of germ- cells. Part of the formative plasm is transmitted in an un- developed form along the chain of cells uniting the repro- ductive cells with the parent ovum-cell, each such cell bearing its little load of germ plasm, while the remainder spends its formative energies in buildiug up the new being. In those organisms in which all, or nearly all, the cells of the soma are capable of reproducing the entire organism, Weismann assumes that the germ-plasm is present in all the cells so endowed, but in the higher organisms, in which only a limited \iumber of cells subserve the reproductive function, the germ-plasm is confined to those. One merit of this hypothesis is, in Weismann's view, that " heredity becomes a question of growth and assimilation — the most fundamental of all vital phenomena " (p. i68). The germ-plasm increases, that is to say, in the same manner as all other living matter : it assimilates and grows, so that he who can explain such assimilation and growth can explain the coming into being of the substance whence new organisms arise. The explanation of the increase of germ-plasm by growth and assimilation is, however, somewhat misleading, as is also the use of the term ' germ-plasm ' itself. They both suggest that this hypothetical plasm is more or less homogeneous in nature. Weismann, it is true, assumes that it possesses an infinitely complex composition, but, while postulating such complexity, he would appear to hold that, taking the entire mass, each portion of the whole has very much the same structure — that it is, for example, very much like sulphuric acid, which, while possessing a distinct molecular structure, is yet in mass homogeneous in a certain sense. The employment of the term 'germ-plasm,' and the statement that it increases by the ordinary laws of assimilation, suggest that (in the case of dioecious organisms) any portion of germ-plasm selected ^ A cell, the offspring of which become partly somatic and partly germ- cells, cannot itself be a germ-cell pure and simple. (Weismann, IhiJ. p. 197.) o PART I.] THE EVOLUTION" OF SEX. 23 indifferently from the male organism, united with any portion of germ-plasm similarly selected from the female organism, is competent to produce a new being, just as any portion of a mass of sulphuric acid united with any portion of a mass of calcium yields gypsum. The only proviso that Weismann makes is that the plasm shall be sufficient in bulk. My conception of the hypothetical germ-plasm is, however, very different from this. I con- tend that, if there be such a thing, it must consist of a number of independent units, each of which is complete in itself — i.e., capable, when united with a similar unit derived from an individual of the opposite sex, of developing into a new being. In order to show that Weismann does not hold this view, I proceed to quote two or three passages from him. " Even a very minute trace of specific germ-plasm," he writes, " possesses the definite tendency to build up a certain organism " (p. i 79). Again he observes tliat the germ-plasm contained in the repro- ductive cells " can only be present in minute quantity at first, but it must undergo considerable increase during the growth of the cell " (p. 213).^ These passages seem to make it ' The following passage similarly tends to show that Weismann does not regard the germ-plasm as constituting so many individual units, complete — in a certain sense — in themselves. Speaking of parthenogenesis he remarks : "We know that force is always bound up with matter," and he maintains that cases in which the ovum only partially develops " are best explained by the supposition that too small an amount of [