PRESS NOTICES OF THE FIRST EDITION. " While written in .1 concise way, it is excccdin;;ly full, and covers the whole ground of gynecology." — Boston Medical and Surgical Journal. " The chapter on the Anatomy of the Female I'clvic C)rgaiis cannot be too highly commended. . . . The author shows a wide knowledge of therapeutics and a com- mendable wealth of resource. . . . The author's descriptions of operations are particu- larly lucid." — Annals of Surgery. " We think it one of the few really good books on gynecology for the general practitioner." — New York Medical Journal. " A useful work. A capital index makes consultation easy." — Edinburgh Medi- cal Journal. " Tiie chapter on Diseases of the FalIo])ian Tube> is up to date, complete, and instructive, as are also the chapters on Uterine Fibroids, Diseases of the Ovaries, and Peri-uterine Inflammation." — American Medico-Surgical Bulletin. "The surgeon will find much to interest him, and he will turn to its ]")ages for hurried consultation niucli oftener tlian to some of the more elaborate ' text-books ' and ' sys- tems.' " — ^Journal of the American Medical Association. "This work is in our opinion the most practical text-book on gynecology (from the standpoint of the general practitioner) thus far published." — Hahnemannian Monthly. " We do not know of any work which is so complete with technique and fairly detailed instructions." — Chicago Clinical Review. PRESS NOTICES OF THE SECOND EDITION. " It has, by the sheer force of its intrinsic merit, shouldered its way through a crowd of more ambitious works, up to the front rank." — Medical Record, New York. " The book has already taken its place among the best works of its kind. ... It is one of the most complete treatises on gynecology which we have." — American Journal of the Medical Sciences. " It is in every respect a good guide for the physician and a first-class book of refer- ence for the gynecologist." — Annals of Gynecology and Pediatrics. "Eminently jjractical and susceptible of practical ajiplication by him who is in need of just such information as it furnishes." — St. Louis Medical and Surgical Journal. " It is in every way a good and safe boolc for both students and practitioners." — Canadian Practitioner. PROFESSIONAL COMMENTS. •'One of the best text-books for students and practitioners which has been published in tlie English language; it is condensed, clear, and comjMehensive. The jirofound learning and great clinical experience of the distinguished author find expression in this book in a most attractive and instructive form. Young ]:>ractitioners, to whom exj)e- rienced consultants may not be available, will find in this book invaluable counsel and help." — Thad. A. Re.\my, M.D., LL.D., Professor of Clinical Gynecology, Medical College of Ohio; Gynecologist to the Good Samaritan and Cincinnati Hospitals. "I can heartily recommend it to students and practitioners. It is concise, compre- hensive, and consistent. I have in my library almost every recent author on tliis sub- ject, and among them all I find none better fitte<l for a text-book than the volume you have just published. I do not see how it can fail of being very popular." — John W. Streetkr, Professor of Gynecology, Chicago Homeopathic Medical College. A TEXT-BOOK DISEASES OF WOMEN BY HENRY J. GARRIGUES, A.M., M.D. GYNECOLOGIST TO ST. MARk's HOSPITAL IN NEW YORK CITY; GYNECOLOGIST TO THE GERMAN DISPENSARY IN THE CITY OF NEW YORK; CONSULTING OBSTETRIC SURGEON TO THE NEW YORK MATERNITY' HOS- PITAL: CONSULTING PHY'SICIAN TO THE NEW YORK MOTHERS' HOME AND MATERNITY HOSPITAL ; EX-PRESIDENT OF THE GERMAN MEDICAL SOCIETY OF THE CITY' OF NEW Y'ORK ; FELLOW OF V THE AMERICAN GYNECOLOGICAL SOCIETY; FELLOW OP THE NEW YORK ACADEMY OF medicine; MEMBER OF THE SOCIETY FOR MEDICAL PROGRESS, OF THE EASTERN MEDICAL SOCIETY, OF THE NEW YORK COUNTY MEDICAL SOCIETY, ETC. WITH 367 ILLUSTRATIONS THIRD EDITION, THOROUGHLY REVISED I'JIILADELI'IIIA W. B. SAUNDEKH & COMPANY It) (^ p( Copyright, 1900, by W. B. SAUNDERS & COMPANY. PRESS OF \V. B. SAUNDERS k COMPANY. TO ABRAHAM JACOBI, M. D., PaOFESSOB OF DISEASES OF CHILDREN IN THE NEW YORK COLLEGE OF PHYSICIANS AND surgeons; ex -president of the medical society of the state of new YORK; EX-PRESIDENT OF THE NEW YORK ACADEMY OF MEDICINE, ETC., ETC., THIS WORK IS RESPECTFULLY INSCRIBED BY THE AUTHOR. PREFACE TO THE THIRD EDITION. When, after the brief space of two years, I had the pleasure of being informed by the publisher that a third edition of my Text- book of Diseases of Women was called for, I resolved to make it in every respect as perfect as was in my power. The entire work has been carefully and thoroughly revised ; what seemed antiquated or of minor importance in a text-book has been left out ; consider- able new material has been admitted, bringing the work up to date as far as it was deemed safe to do so in a text-book, which, first of all, must aim at soundness of doctrine. Many new illustrations have been added. Instead of making a new index, which is a compara- tively easy matter, that which has gradually been developed by use of the two preceding editions has been retained, improved, and increased, facilitating research in a work containing information upon so many different subjects. By these improvements I have tried to make the book worthy of the kind reception accorded it by the profession and the press, and I trust that this edition will be found a still more reliable guide and handy counsellor than its predecessors. In the preparation of this third edition for tlie press I have been assisted by Drs. Evelyn Garrigue, r^eon F. (Jarrigues, and Harry G. Watson ; and new drawings have been made by Mrs. Editii Ilutchins. 107 East Sixty-Second Street, New York, June, 1900. PREFACE TO THE FIRST EDITION. The term " Diseases of Women " is understood to designate the affections of the genital organs in the female sex other than those connected with pregnancy, childbirth, and the puerperal state. That branch of medical science and art that is devoted to this subject is called Gynecology. In writing this book I have first had in view the large class of physicians who have nut had the advantage of hospital training, and loho go to a 'post-graduate school in order to learn gynecology. They can only stay a short time, and they want a full but concise exposition, up to date, of the nature and treatment of the diseases peculiar to women. Secondly, I have tried to satisfy the requirements of that much larger class who would like to go to such an establishment, but loho find it impossible to leave their practice. They are busy men, who have to keep abreast of recent progress as best they can in all branches of a general practitioner's work. They want information about the present state of gynecology, but cannot find time to study large works. If in large cities it is better for the general practitioner, as well as for his patient, to leave the treatment of most gynecological cases to those wlio have special experience and skill in this line, the same does not always hold good in country practice. The long distances in this immense country make it very difficult, and often impossible, to send patients to places w^here they can be treated by specialists. American physicians are enterprising, and some men practicing in a village have achieved world-wide renown, and become the leaders of their city confreres. Finally, I think the book will be found useful by undergradu- ates studying in medical colleges. They will probably at that stage PREFACE. 9 of their development skip many details about operations, which they will be glad to take up later, when the responsibility of a medical practitioner lies heavy on their shoulders. The division into a gen- eral and a special part will presumably be useful for the beginner, and he will hardly care to pay much attention to what has been placed in notes under the text. This being a book for General Practitioners and Students, I have omitted all reference to the historical development by which gynecology has attained its present stage, as well as all reports of special cases. The limits and the nature of the work have not allowed me to speak of all methods of treating every disease, but I have striven to give a clear and succinct description of the best modes of treat- ment ; and the reader will in this book find many details which he would look for in vain in larger works. My aim has been to write a practical work. The reader's time is not taken up by theoretical discussions, and the pathology has been treated very briefly. On the other hand, I have tried to help the reader to make a diagnosis, and to teach him how to treat the different diseases. In this respect I have gone into minute details affording manifold information about points which practitioners who live in large cities learn from one another or by visits to the shops of the instrument-makers. I have treate<l so discursively of the auatomy of the female geni- tals because this subject, to a great extent, has been worked up by the gynecologists themselves, and is not as yet described satisfactorily in the text-books of anatomy, but only in large Avorks of an encyclo- pedic character or in articles in journals to which many have not access. I exjject to be criticised for having devoted special chapters to Hemorrhage and Leucorrliea. I know well that they are not dis- eases ; but they are symptoms that ])lay so great a j)art in tlie diseases of women, and so often require symptomatic treatment, that I take it to be in the interest of tlie general ])ractitioner to treat them sep- arately ; and besides, by so doing infinite repetitions are avoided. This l)eing a text-book for beginners and a manual foi- general practitioners, names of authors have been omitted as much as possi- ble from the text, except when it was necessary in order to designate 10 PREFACE. different metJiixls of operations. In making use of the work of American authors I have, however, given them credit for it in foot-notes, and I trust that it will be found that a large amount of information of this kind has been embodied in the text. In indicating the treatment of the various affections, I mention always the simpler and innocuous means before the more compli- cated and dangerous, medical and electrical treatment being accorded precedence over surgical. Throughout the work a chief object has been to give modes of treatment as they arc practiced in America, by which I hope that it will be found more useful for American students and practitioners than the works written by or translated from foreign authors. The Illustrations form a complete atlas of the embryology and anatomy of the female genitalia, and represent numerous operations and pathological conditions. Many come from my own operations^ dissections, and microscopical examinations. 155 Lexington Avenue, New York, January, 1894. CONTENTS. GENERAL DIVISION. PART I. PAGE DEVELOPMENT OF THE FEMALE GENITALS 19 PART II. ANATOMY OF THE FEMALE PELVIC ORGANS 35 PART III. PHYSIOLOGY 116 CHAPTER I. Puberty 116 CHAPTER II. Menstruatiox and Ovulation 117 CHAPTER III. Copulation 12.3 CHAPTER IV. Fecundation 123 CHAPTER V. The Climactekic 125 PART IV. ETIOLOGY IN GENERAL 129 PART V. ILXAMLVATION IN GENERAL l.'M Verbal Eraminntion l.'M Physical ICxaminntiou l.'i" I. Positions ];5S 11. Examination of the Pelvis 1 II in. Examination of the Alxlomcn KiO IV. Other .Means of Investigation eommon for Pelvic and Ahdominul Diseases ](!! 11 12 CO^^TENTS. PART YI. PAGE TREATMENT IN GENEEAL 172 CHAPTER I. Preventive Treatment 172 CHAPTER II. External Treatment 174 A. Applications 174 B. Injections 175 C. Curettage 180 D. Tamponade 182 E. Hemostasis 186 F. Dilatation 191 G. Drainage 191 H. Bloodletting 194 I. Heat and Cold 195 J. Counter-irritation 196 K. Tapping and Aspiration 197 L. Abdominal Belt 199 M. Massage 199 N. Gymnastics 200 0. Operations in general 201 1. Time for Operating 202 2. Preparation 202 Disinfection, Asepsis, and Antisepsis 209 3. Anesthesia 218 4. Shock 224 5. Common Instruments and their Use 226 6. After-treatment 239 CHAPTER III. Internal Treatment 240 CHAPTER IV. Electric Treatment 246 PART VII. ABNORMAL MENSTRUATION AND METRORRHAGIA 255 CHAPTER I. Amenokrhka 255 CHAPTER II. Vicarious Menstruation 258 CHAPTER III. Dysmenorrhea 259 CHAPTER IV. Precocious and Tardy Menstruation 261 CONTENTS. 13 CHAPTER V. PAGE Menoeehagia 262 CHAPTEE VI. Meteoeehagia 264 CHAPTEE VII. Geneeal Menstetjal Disoedees 264 PART VIII. LEUCOEEHEA 268 SPECIAL DIVISION. PART I. DISEASES OF THE VULVA 273 CHAPTEE I. Malfoemations 273 CHAPTEE II. EuPTUEES (Heenije) 273 CHAPTEE III. TuMOES Connected with the Extrapelvic Portion of the Eound Lig- ament 280 CHAPTEE IV. Injuries 283 CHAPTEE V. Vulvitis 285 CHAPTER VI. Inflammation of the Urethral Ducts 289 CHAPTER Vn. Gangeexe of the Vulva 289 CHAPTEE VIII. Exanthematous Diseases 290 Herpes Progenitalis 290 CHAPTEE IX. Teichiasis 291 CHAPTER X. Pburitus Vulv^ 291 Burning Sensation in the (ienitjils and the Abdomen 29.'J CHAPTER XI. Hvperestuesia of tup; Vulva 291 14 CONTENTS. CHAPTER XII. PAGE Tumors of the Vulva 294 CHAPTEK XIII. Tuberculosis 306 CHAPTEK XIV. Progressive Atrophy of the Nvmpikk, ok Kraurosis 307 CHAPTEE XV. Diseases of the Vulvovaginal Glands 308 CHAPTEE XVI. Venereal Diseases -. 310 CHAPTEE XVII. Prolapse of the Urethra 315 CHAPTEE XVIII. Masturbation 316 Clitoridectomy 319 PART II. DISEASES OF THE PEEINEUM 320 CHAPTEE I. Injuries 320 CHAPTEE II. Garrulity of the Vulva, ok Flatus Vaginalis 342 CHAPTEE III. COCCYGODYNIA 342 CHAPTEE IV. Hygroma Perin^ei 344 PART III. DISEASES OF THE VAGINA 345 CHAPTEE I. Malformations 345 A. Maltbrmatious of tbe Hymen 345 B. Malformations of the Vagina 347 CHAPTEE II. Vaginal Entekocele 354 CHAPTEE III. Pkolapse of the Anterior Wall of the Vagina ; Cystocele 356 CHAPTEE IV. Prolapse of the Posterior Wall of the Vagina ; Eectocele 359 r^ENERAL PEOLAP.se AND INVERSION 359 CONTENTS. 15 CHAPTEK Y. PAGE Injueies; Thrombus, oe Hematoma 360 CHAPTEE VI. FoEEiGN Bodies 362 CHAPTER VII. Vaginitis 363 CHAPTEE VIII. Gangeene 372 CHAPTEE IX. Eeysipelas 373 CHAPTEE X. CiCATEICES 373 CHAPTEE XI. Vaginismus 375 CHAPTER XII. Neoplasms 378 CHAPTEE XIII. FiSTULiE 383 A. Urinary Fistulse 383 Genital Clcisis 3!)7 Urinals 397 Operations for Incontinence 3i»8 B. Fecal Fistula 3it!» PART IV. DLSEASES OF THE UTERUS 106 CHAPTER I. Malfor.mations 106 A. Exce.s.sive DcvelopineTit and Precocity 106 B. Arrest of Development during tlie First Half of Intra-utcrine Life . . . 406 C. Arrest of Development during the Second Half of Intra-uterine Life . .111 D. Irregular Development 113 rilAPTEU II. Ix.hkiks -Ill rilAPTKR III. FoKKHJN Bodies 122 CII.M'TKR IV. Metritis I-,'.'! CII.M'TKK V. Closukk ok the T'ti;iu« L\(uriuKi) Atuksia) 1 in CHAPTKi: VI. Stk.nosis of iiiK Ckkvix Ill 16 CONTENTS. CHAPTER VII. PAGE Ulceks op the Cervix 444 CHAPTER VIII. Hypertrophy of the Uterus 444 CHAPTER IX. Acquired Atrophy of the Uterus (Superinvolution) 451 CHAPTER X. Gangrene of the Uterus 452 . CHAPTER XI. Hysteralgia 452 CHAPTER XII. Displacements of the Uterus 453 CHAPTER XIII. Neoplasms of the Uterus , 492 PART V. DISEASES OF THE FALLOPIAN TUBES 553 CHAPTER I. Malformations 553 CHAPTER II. Salpingitis 554 CHAPTER III. Displacements 578 CHAPTER IV. Neoplasms 578 PART VI. DISEASES OF THE OVARIES 581 CHAPTER I. Malformations 581 CHAPTER II. Foreign Bodies 582 CHAPTER III. Displacements 582 CHAPTER IV. Hyperemia and Hematoma 586 CHAPTER V. Oophoritis 590 Gvroma and Endothelioma 597 CONTENTS. 17 CHAPTER VI. PAGE Neoplasms 601 A. Ovarian Cysts 601 I. Dropsical Graafian Follicles 602 Rokitanski's Tumor 604 II. Proliferating Cysts 605 a. Glandular 606 b. Papillary 614 c. Mixed 615 III. Dermoid Cysts 615 IV. Tubo-ovarian Cysts, cr Hydrocele of the Ovary 617 B. Solid Ovarian Tumors 671 CHAPTER VII. Oophoralgia 678 PART VII. DISEASES OF THE PELVIS 679 (The Peritoneum, the Connective Tissue, the Vessels of the Pelvis, and the Liga- ments of the Uterus.) CHAPTER I. Malformations 679 CHAPTER II. Aneurysm of the Uterine Artery 679 CHAPTER III. Diseases of the Bkoad Ligament 680 CHAPTER IV. Diseases of the Roind Ligament 684 CHAPTER V. Diseases of the Sacro-uterine Ligament 684 CHAPTER VL Pelvic Hemorrhage 685 CHAPTER VII. Perimetric Inflammation 693 CHAPTER VIII. Sarcoma and Car( i.voma of the Pelvic Peritoneum and Connective Tissue 714 CHAPTER IX. Hydatids (Echinococcii of the Pelvis 715 APPENDIX. L STERILITY 718 II. LACK OF ORGASM 723 IIL INTE.STINAL SURGERY 724 2 DISEASES OF WOMEN OR aYi^ECOLO GY. GENERAL DIVISION. DISEASES OF WOMEN. GENERAL DIVISION. PART I. DEVELOPMENT OF THE FEMALE GENITALS. The history of the development of the female genitals being an indispensable key to the understanding of their malformations, which are of frequent occurrence and often of great im|)()rtancc in regard to life and happiue&s, we give here a resume of the same.* The Wolffian Ducts. The first organs belonging to the genital si)here, whicii appear in the male as well as the female embryo, are the Wolffian ducts. There is one on either side of the body, situated between the proto- FlG. 1. Tniiisverse Section throiiRli the Mcdiiui I'lirt of the Rodv of the Kmhrvo of a Katibil o days and two hours (enlarged 158 times); r/r/. hvpohlast ; i/r, intesiiiial u'roove; rh. chord : no, deseendiiit; aorta; un, protovertelmi ; mr, inednllarv tube : inui, WoKlian (Uu. visceral division of the mesohlast : <i, vessels in the deeper'ijarlsof the visceral blast: h]), parietal mesohlast ; h, epihiast ; ;</>, pleuro-peritoiical cavity (I\'(>llil;eri. vertebral column and the lateral plates (Fig. 1). Originally it * Tliis is an abstract of the author's more ('lal)or;ite articile on tlie siiKjcct Sj/sirm of Gynecolot/i/ by American Authors, edhed hv M. I ). Mann, I'liiladel 1887. f nine . nolo duel; in I pliia, 20 DISEASES OF WOMEN. solid cord, but it is later tunnelled, so as to form a tube. The upper end lies on a level with the fourth or fifth vertebra, and soon conneets with the Wolffian body, forming its outlet. The lower end opens into that part of the alluntois which is situated in the body of the embryo and communicates with the cloaca. After the separation between the urogenital canal and the intestine the Wolf- fian duct ends in the urogenital sinus (Fig. 2). Fig. 2. Sagittal Section through the Posterior Part of tliu P)0(ly of the Embryo of a Rabbit of eleven days and ten liours (enlarged 45 times) : w(/, Wolflian duct: n, ureter; Ji', beginning formation of the kidney ; urj, urogenital sinus ; cl, cloaca ; h</, region in which, in the mesial plane, the hind-gut opens into the cloaca ; erf, post-anal gut ; a, anus, or fissure of the cloaca ; s, tail : r, perineal fold (Kolliker). In the male the Wolffian duct becomes, in the course of time, the tail of the epididymis and the vas deferens. In the female it disap- pears more or less completely. Still, in the cow and the sow it per- sists as Gartner\s canal. In woman remnants of it are found in the broad ligaments. The Wolffiax Bodies. Shortly after the AVolffiian ducts the Wolffian bodies appear. These are two long prismatic bodies, one on either side of the median line (Fig. 3). The upper end is fastened to the dia- phragm, the lower to the inguinal region by a ligament which, in course of time, becomes the round ligament of the uterus, or the gubernaculum testis in the male (Fig. 4). They fill the hollow of the posterior wall of the abdominal cavity, leaving a narrow fissure on either side. In the inner one of these is later developed the gen- ital gland ; in the outer lies the Wolffian duct, and later also the Miillerian duct. DEVELOPMENT OF THE FEMALE GENITALS. 21 These bodies originate from the eudothelium of the peritoneum, and form at first a long row of pear-shaped solid bodies. Later, Fig. 3. Human Kmhryo of thirty-five days (front viowi: 3, Ifft fxtcrnal nasal iiniccss; I, siijiorior maxillary process: z. t<ini.'ue: b. aortic hiilb: b , lirst ju'riiiunt'iit aortic arch ; b", scconii aortic arcli ; '; ". thinl aortic arcli, or <liictns Botalli : //. tlic two tilamciits to the riuht anil the left of tliis letter ate the imlmonary arteries, wliicii jus! betiiii to he <levi>lo])c(l ; r. the trunk of the sn|H-rior vena cava ami ris,'ht azvLros vein ;' <•'. the conuiion venous siiiu> of the lieart : r", the common tiiink of tlie left ve'na cava anil left azy<.,'os vein ; n, left anriele of the lieart; ?'. rij,'ht ventricle : r', left ventricle; (i», liin}.'s ; r, stomach :./. left omiihalo- mesenlcric vein ; x, continuation of tlie >ami- behiml the I)ylonl^, whieli afterward becomes the vena porta; x, vilello intestinal ihict ; u. riL'hl omiihalo-mesenterie artery; //'. W'olllian liody ; /, ^nt : /(, nml)ilie:il artery : n. umliilieal \eiii ; >, tail : .'', anterior limii ; .'' , posterior limb. The liver ha- been reini'>vi(l. 'I be u liiie b.-iml at the inner side of tlie Woltliaii body is tin- genital uland. ,-11111 the two while liaiid- at its niiier >idi' are ilie .Mul- leriaii and the Wolllian duels (Co^tc). tii('.«;(; are .s(,'|)aratcd from the jx'ritoncnin luid hccniiic hollow. Innii- iiio; a row of vesicles called the sci/uii'tildl rcsic/is, each of whii'li soon coiiiiccls with the Wolllian duct by the absorption ol'tlic tissue iuter- veiiiu'' between their cavities and the lumen of the ilnd. The Ioihk r 22 DISEASES OF WOMEN. vesicles appear now as branches of the Wolffian duct (Fig. 5), which grow rapidly and connect at the other end with arterial tufts in the siune way :is the uriniferous ducts and the Malpighiau tufts in the kidneys. In the male the Wolffian body is later transformed into the epidi- didymiH and the organ of Gindd^s (Fig, 0) ; in the female into Rosen- FiG. 4. The Genital and Urinary Organs of the Embryo of Cattle : 1, from a female embryo IJ/^ inches long (double size) : w, WolflBan body : wr/, WolflBan and Miillerian ducts ; i, ineuihal ligament of Wolffian body ; o, ovary with an upper and lower peritoneal fold; n, kidney ;nM, suprarenal body; g, genital cord, composed of the united Wolffian and Miillerian ducts. 2, from a male embryo 2)/, inches long (nearly three times natural size) : one of the testicles has been removed. Letters as in Fig. 1, and, besides, to, Miillerian duct ; m', upper end of the same ; h, testicle ; h', lower ligament of testicle ; h'\ upper ligament of testicle ; d, diaphragmatic ligament of Wolffian body ; a, umbilical artery ; v, bladder. 3, from a female embryo (enlarged nearly three times). Letters as in Figs. 1 and 2, and, be- sides, t. opening of the upper end of Miiller's duct ; o', lower ovarian ligament ; ti, thiclj- eued part of Miillerian duct, which later becomes the uterine horn (Kolliker). rauller's organ, or the parovarium, and stray tubes found between the parovarium and the uterus (Fig. 7). The Ovaries. In the beginning the sexual glands are identical in both sexes. At the end of the second month the ovary and tlie testicle l)egiu to diffiir from each other, the testicle be(;oming broader and sliorter, while the ovary remains long and narrow. The ovary has a much more developed columnar epithelium than the testicle. An early difference is also said to be found in the distribution of the l)l()od vessels. The testicular circulation is peripheral, the main artery DEVELOPMENT OF THE FEMALE GENITALS. 23 coursing ov^er the dorsal aspect of the organ, and giving off rib-like branches, which in turn send penetrating branches into the gland. Between the arteries are situated the collecting veins, which unite at the base of the testicle to form the sperm- atic plexus. In the ovary, on the con- trary, the arteries with their accom- panying veins enter the center of the organ, where they branch tree-like, and terminate as a fine capillary anas- tomosis in the tunica albuginea.' The sexual glands are situated on the inner side of the Wolffian body (Fig. 4), to which tliey are fastened by a fold of the peritoneum called the mesorc'hiiDii in the male and the meso- ariuni in the female. At the upper end is a ligament which unites with the diapliragmatic ligament of the Wolffian body ; at the lower end is another ligament, which is fastened to the Wolffian duct, opposite the starting-])oint of the inguinal liga ment of the Wolffian body, and which Posterior End of tlic Embryo of a Dog, with buddinjr allanloid. Tliemeso- blast and the liypdblast, or the begin- ning of the intestine and the neigh- boring parts of tlie blastodermic vesicle, are thrown back in order to show tlie Wolflian bodies (enlarged 10 times) : o, Wolflian bodies, with the duct and the simple blind canals; b, protovertebrai ; c, spinal marrow; d, entniiice to the pelvic intestinal cavity iBif-ehoff). later becomes tlie permanent li(/(iinciit of the ovary. Tlie sliape of the ovary undergoes threat chano^es. At first it is a lono: flat body. Later it grows, especially at the edges, so that a trans- verse section has the shape of a bean or a mushroom (Fig. 8), and finally the transverse section becomes pear-shaped. The ovary is subject to a c/csw/j^ just as the testicle. At the birth of the child the ovaries are yet situated above the ileo-jx'ctinetd line, and descend into the true pelvis during the first two or tliree months of the child's life. This descent is partly apparent and partly real: it is chiefly due to the greater growth of the jiarts above the ovaries ; l)ut, besides that, a shrinking of the round ligament of the uterus tak(.'s j)Iace, by which the ovaries indirectly are pulled down. At the SJime time there is a (•hang(! in ])osition by whicii the upper end sinks considerably downward and outward, and the whole organ turns around its long axis until the inner edge becomes the lower, where the hiluni is; the outer becomes the upj)er, free edge; the anterior surface becomes the inner, the posterior becomes the outer. The relations to the l^'allopian tube are changed in such a way that the ' J. (i. (lark, .luliiui JL/pkins Jloapilid Bulletin, Nos. 94— IH), Jan., I'd)., Mar., iS'.ti* 24 DISEASES OF WOMEN. ovary, instead of lying inside of the Miillerian duct, as it does at first, finally lies behind and below the tube. Fig. 7. Oabd E Fig. 6. -H U u ■ - Fig. 6.— Internal Genitalia of a Human Fetus, 9 cm. long (enlarged 8 times) : H, testicle : E, epididymis (epididymal part of Wolffian body) ; U, organ of Giraldes (uropoetic part of Wolffian body) ; G, bundle of connective tissue containing vessels : Y, vas deferens (Wolffian duct) (Waldeyer). Fig. 7.— Internal Genitalia of a Human Female Fetus. 9 cm. long 'enlarged 10 times) : 0, ovarv ; T, tube ; abd., abdominal ostium of tube ; E. parovarium ; U, uropoetic part of the Wolff- ian bodv remaining as tubes between parovarium and uterus ; Y. Wolffian duct disap- pearing lower down; Mp., Malpighlan bodies iWaldeyer). The ovarian vessels enter originally at the upper end of the Fig 'rian<:verse Section of Ovary of Human Embryo of three months (enlarged 43 times • a. mesoarium ; a', stroma of the liiluni (medullary substance); b, glandular tissue (cortical substance) (Kolliker). DEVELOPMENT OF THE FEMALE GENITALS. 25 mesoarium from the posterior wall of the abdomen, and are enclosed in a fold of the peritoneum, which in the course of time becomes the infundibulo-pelvic ligament, extending from the fimbriae of the tube to Fig. 9. * mt Transverse Section through the Ovarian Region of a Human Embryo of five months; lower surface seen from above (enlarged 3 times) : oi, os iliura ; s, sacrum ; mo, mesoarium and hilum of ovary, bounded by two lii)s ; o, cut surface of the ovary ; v, free ventral surface, or lateral jmrt of the ventral surface, of the ovary ; 7(i, rectal surface of ovary, or medial part of its ventral surface: t, tube; vd, mesentery of tube (later ala vespertilionisi; r, rectum; «, uterus; vr. ureter; o;(, umbilical artery; ie, external iliac vessels ; nc, ante- rior crural nerve (KoUikei ;. the wall of the pelvis. To the outer side of the mesoarium is attached the mesosaljjinx (Fi^. 9), or mesentery of the tube, which later is called Ovary of a Human Fetus of ten or cli'ven week- : '/, ^uperficial stratum of ci connective tissue: '•, trabeculii: of CDiineclive tissue, the cells having bee mesoarium : e, i)art near surface seen with liigher power, n, naiurul size o (H. Meyer;. ■lis: /<, lay n reiuuve f the siiec i; (/, iiiu'u 26 DISEASES OF WOMEN, ala vespertilionis (the bat's wing), and contains the remnants of the Wolffian body, especially the parovarium, but at this period has no connection with the uterus. The Formation of Ova and Graafian Follicles. — At the earliest stage the ovary is represented by a mass of cells developed from the peritoneal covering of the Wolffian body, and soon a protuberance of connective tissue enters from behind into this cell-mass. These two elements build up the whole ovary, the cells forming the parenchyma, or glandular element, and the connective tissue the stroma. Pro- FlG. 11. Part of Ovary near Surface, from Human Fetus of sixteen weeks, showing formation and separation of ova (H. Meyer). Fig. 12. Part of Ovarv near Surface, from Human Fetus of twenty-eight weeks. In some places appears the permanent epithelium, composed of a single layer (H. Meyer). Fig. 13. Part of Ovary near Surface, from a Human Fetus of thirty-six weeks. The single layer of epithelium is interrupted by a belated primordial ovum with its follicular epithelial cells (H. Meyer). longations from the connective tissue grow in between the cells and separate them, forming groups, and grow together over them; but from this cover new prolongations start, and new cells are constantly formed on the surface (Fig. 10). In this way irregular tubes filled DEVELOPMENT OF THE FEMALE GENITALS. 27 with cells are formed which connect with one another, much like the canals found in a sponge (Figs. 11, 12, 13); but finally the whole surface is only covered by a single layer of cells, the columnar epi- thelium, under which is found a layer of connective tissue, the albu- ginea, and under that we find clusters of cells surrounded by connect- ive tissue (Fig. 14), or sometimes a long row of large cells, each Fig. 14. ,<^^ . ' '' Part of Section from Surfaoc to Hilum of Ovary of (iirl tiireu days old : s, single layer of epi- thelium yet in eoniiection with cluster of primordial ova. All ova have disappeared from the surface. A broad layiT of stroma separates in most ])laces llu- ei>ithelinni from the follicular zone. The far'tlur we go froin the surface toward the hilum. the fewer ova are there in one nest, until, finally, there is only one in its primary follicle ; n, natural size of the wliole ovary ill. Meyeri. surrounded by smaller cells, until liiially all these clu.sters and col- umns are broken up into small compartments, each containing one 28 DISEASES OF WOiMEN. large cell and one or more smaller ones (Fig. 15). The large cells have each a large nucleus and nucleolus, and are the future ova, and Fig. 15. Fig. 16. Perpendicular Section through the Ovary of a Bitch of six months (Hartnack, ?): a, the epi- thelium : b, epithelial pouch opening on the surface ; c, larger group of follicles ; d, ovarian tube filled with ova ; e, oblique and transverse sections of ovarian tubes (Waldeyer). are called primordial ova ; and the small cells multiply and form the epithelium of the j)^'i'>nary follicles, which are the beginning of the Graafian follicles (Fig. 16). The small cells increase in number and form several layers. A fissure is formed between them, and a fluid ac- cumulates in this space, the begrinning of the future liquor j'ollicidi. The outer layers form the epithelium of the Graaf- ian follicle, the so-called viembrana granulosa; the inner continue to sur- round the ovum, forming the discus prolifjerus (Fig. 1 7). The fibrous mem- brane of the follicles is formed by a dif- ferentiation of the surrounding stroma. It will be seen from the above de- scri])tion that the ova, the surface epi- thelium of the ovary, and the epithe- lium of the Graafian follicles have all one common origin, the cellular mass formed on the inner edge of the AVolffian body.' As mother to so many epithelial formations, this is called the r/enn-epithelium. The formation of ova on the surface of the ovary ceases from the time the single layer of epithelium is formed, about the end of the seventh ' According to J'oulis and his followers, the germinal epithelium only forms the ova. while the epithelium of the primary follicles is derived from the connective- tissue stroma. Three Graafian Follicles from the Ovary of a Xew-born Girl (en- larged 350 times) : 1, natural condi- tion ; "2, treated with acetic acid ; a. structureless membrane ; 6, epi- thelimn (memlirana granulosa) ; c, yolk : d. germinal vesicle, with ger- ininal spot ; e. nuclei of the epi- thelial cells ;/, vitelline membrane (Kolliker). DEVELOPMENT OF THE FEMALE GENITALS. 29 month, but it seems that the ova themselves multiply by division (Fig. 18). Their number is enormous: it has been computed that the two ovaries together contain 72,000 ova. The Mullerian Ducts. The Mullerian ducts appear shortly after the Wolffian body as a funnel-shaped invagination from the endothelium of the peritoneum Fig. 17. Graafian Follicle from a Girl seven months old (enlarged 220 times ; natural size, 0.351 mm. longest diameter/ : a. epithelium (membrana granulosa) detached from fibrous membrane : h, discus prfiligerus, situated far away from the surface. It contains the ovum, on which the zona pellucida and the germinal vesicle are visible. The surrounding fibrous mem- brane is not yet separated into two layers, and there is no distinct line of demarkation between it and the surnninding stroma (Kolliker). at the inner side of the upper end of the Wolffian body (Fig. 19). Thence it extends behind this body and comes to lie outside of the Wolffian duct, but turns in a spiral line round the latter, so as to Fig. 18. 1 m Primordial Ova undergoing division, from a Human Kmbryo of si.x months (enlarged I'K) times) : 1, two primordial ova surroiiiideil by a conmion layer of eiiithelium, one of which - has a prolongation by iiuans of which it prolnilily was attached to aiiotlier ovum, as in 2, where two jirimordial ova are linkeil tosrctlier by a band of protoplasm, the whole sur- rounded by one epithelial layer; 3, primordial ovum with two nuclei (germinal vi.'sicles) (KiiUiker). 30 DISEASES OF WOMEN. pass in front of it, and finally lie behind it. The lower part is at firet formed by a solid column of cells, which later is tunnelled so as to form a tube. The JMiillerian duct has a mesentery, by which it is fastened to the Wolffian body. After the disappearance of that body it springs from the posterior abdominal wall ; still later trom the mesoarium (Fig. 9), until, finally, in the fully-developed body we find it as part of the broad ligament of the uterus. In the male the JMiillerian ducts soon disappear, leaving as rem- nants the hydatid of Morgagni on the epididymis and the vesieula Fig. 19. Transverse Section through the upper end of the Wolffian Body of the Ernbryo of a Rabbit of fourteen days (enlarged 114 times): w^r, Wolffian duet; ??!, connection between a tubule of the Wolffian body with a Malpighiari body : t, entrance to the Miillerian duct (later the abdominal ostium of the Fallopian tube) ; gg"', mesentery of the Wolffian body, containing a glandular tubule; I!', surface of the liver; hb, posterio'r abduminal wall; 7)iff, lateral part of the Miillerian duct (KoUiker). prostatica (sinus copularis, or male viern^). In the female they form the Fallopian tubes, the uterus, and the vagina. The Fallopian Tubes. — The Fallopian tubes arc formed of that part of the ^liillerian ducts which lies above the round ligament of the uterus (the inguinal ligament of the Wolffijin body, Fig. 4). The cells of the Mall form the fibrous, muscular, and mucous coat of the fully-developed tube, and fringes grow out around the abdominal opening, forming the fimbrke. The duct follows the ovary in its descent, and comes to lie above and in front of that organ, running from the upper corner of the uterus to the wall of the pelvis. DEVELOPMENT OF THE FEMALE GENITALS. 31 The Uteinis and the Vagina. — The part of the Miillerian ducts below the round ligament forms, together with the lower ends of the Fig. 20. Fig. 21. Transverse Section of the Genital Cord of the Embryo of a Cow, 1]4 inches long (enlarged 14 times) : 1, from the upper end of the cord (the ducts have been cut somewhat obliquely) ; 2, somewhat lower down ; 3 and 4, from the middle of the cord, showing incomplete and complete fusion of Miiller's ducts ; 5, from the lower end, showing the two Miillerian ducts separated ; a, anterior side of genital cord ; p, posterior side ; m, Miiller's ducts ; wg, WolflBan duct (KoUiker;. Wolffian duets, a quadrangular cord with rounded edges, the gcmtal cord (Fig. 20). The tissue that separates the two Miillerian ducts is gradually absorbed until there is one canal instead of two at the end of the second month. Tlie genital cord is developed so as to form the uterus above and the vagina below. While the fusion of the Miillerian ducts is incomplete, they are yet separated above, forming the two horns of the uterus (Fig. 21). About the middle of pregnancy t'ne uterus forms one sac without horns (Fig. 22). The ]Miillerian ducts o])en into the lower part of the uraclius, that ])art of tlie allantois whicli is included in the body, and later forms the bladder (Fig. 23). Tliis lower part, situate below the openings of the Miillerian and Wolffian ducts, is called the urogenWd .sinus (Fig. 2). Originally this sinus opens into tlie cloaca (Fig, 24). Fiater a septum is formed, dividing the cloaca and then^by separating the sinus urogenitalis from the rectum, and the urogenital o])ening from the anus, and forming tlie prr'riieum (Fig. 25). The urogenital sinus grows much less than the other |)arts. The urethra is differentiated as a sj)e('ial organ from the bladder, with which it heretofore formed one sac call Tubes, and of Htnnan Embryo from tlie toiitli weelc, 'it'i mm. long: 1. natural size; 2. enlargeil 4 times; n. round ligament ; 6, reclum(H. Meyer). d tl ic uraclin and the vagina is undergoing a great development. Thus the change 32 DISEASES OF WOMEN. is brought about that the urogenital sinus, which seemed to be a con- tinuation of the bladder, now appears as the continuation of the vagina, and forms the vestibule (Fig. 26). Fig. 22. Abdominal and Pelvic Viscera of Female Fetus of five months (length from vertex to sole, 19 cm.) :<, tube; r, round ligament; v, bladder; u, umbilical artery; ur, urachus; c, cacum; pv, vermiform appendix (Kolliker). In the fifth and sixth months the vagina is separated from the uterus by the formation of a ring (Fig. 26, 3), which finally becomes the vaginal portion. Fig. 23. Fig. 24. Fig, ® Fig. 2S.—al!, allantois. which becomes the bladder : r, rectum : m, Miillcr's duct, which later is transformed into the vagina; a, indentation of the skin, which forms the anus (Schroeder). Fig. 24.— d, cloaca ; all, allantois; m, Miillcr's duct ; r, rectum (Schroeder). Fig. 25.— sm, urogenital sinus ; r. rectum, separated from the former by the perineum ; v, vagina (lower part of Miillcr's duct) ; b, bladder ; u, urethra ^Schroeder). About the same time the cervix is being distinguished from the DEVELOPMENT OF THE FEMALE GENITALS. 33 body of the uterus by the formation of transverse folds on its mucous membrane. In the new-born child the cervix is nearly twice as long as the body of the uterus, and its walls are much thicker. The anterior and posterior surfaces of the body have longitudinal folds, and in either edge is found another longitudinal ridge from which start to both sides fine transverse folds, ending at the longitudinal folds of the surfaces. They are a continuation of the transverse folds of the cervix. Later in life all these folds disappear from the cavity of the body of the uterus, while those in the cervix remain. During the first ten or twelve years of the child's life the uterus changes very little, even in size, but at the approach of menstruation the organ undergoes a great development; this increase in size con- tinues until the rest of the body has attained the limit of its growth.. Fig. 26. 1 "3. Urogenital Sinus and its Appendages, from Human Embryos (life-size) : 1, from a three- months' fetus ; 2, from a four-months' ; 3, from a six-months' ; b, bladder ; h, urethra ; ug, urogenital sinus ; g, genital canal (common rudiment of vagina and uterus) ; s, vagina ; u, uterus (KoUiker). After the differentiation between the uterus and the vagina, about the middle of pregnancy, the vagina becomes much wider, and its columns and rugae make their appearance. The Hymen. — The hymen is formed in the fifth month by a devel- ojHiient of the posterior wall of the vagina.^ ' In tlie above description of the formation of tlie female genitals, I have chiefly followed KoUiker and Waldeyer. According to I). IJerry Hart {Trans. Edinburgh Ohsl. Soc, 1895-'yG), .several points would have to be added or corrected. The ducts of Miiller arise probably from the mesobiast, the Wolffian ducts from the epiblast. JJefore the hymen is developed — i. e., up to the second and third month of fetal life — the vagina is formed by the coalesced ducts of Miiller, but the lf)wer end has no opening. At the beginning of the third month, two bulbs form from the lower ends of the Wolffian ducts, the perij)hery of these bulbs being formed of the more active cells, the center of cells of a more .scpiamous type. Jiy the j)n>lifera- tion and sj)read of these cells the Miillerian vagina has its lumen blocked, the fornices and vaginal portion mapped out. The Wolffian bulbs coalesce, break down in the center, and as the Wolffian cells in the center of the Miillerian vagina do the same, the normal vaginal lumen is formed. Tlie hymenal o|)ening is brought al)(>ut by the epithelial involution of the sinus urogenitalis from below meeting the dis- tending Wolffian bulbs above. The Wolffian ducts thus supply the epithelium of the vagina and develop the hymen. 3 34 DISEASES OF WOMEN. The Vulva. We have seen that originally the urogenital and the digestive tract open into one common cavity called the cloaca. Toward the end of the first month the cloaca opens on the surface of the body by a slit called the cloaca! opening. In front of this opening there appears in the sixth week a protuberance called the f/enif(d tubercle, which soon thereafter is surrounded by two lateral folds called the genital folds. Tiie genital tubercle grows, and toward the end of the second month there is formed a groove on its lower surface which extends to the cloacal opening, and is called the genital furroiv (Fig. 27). So far, the external genitals are identical in both sexes, and they cannot be distinguished before the tenth week. The genital tubercle becomes the clitoris, the genital folds form the labia majora, the edges of the geni- tal furrow are developed into the labia minora, a fold of which later surrounds the clitoris, forming its prepuce. In the tenth week the separation between the rectum and the uro- genital sinus is consummated. The genital folds grow together at their posterior end, forming a perineum, which unites with the partition be- tween the urogenital sinus and the rectum. While at first the two canals are in close contact, in the fourth month there is a well-formed perineal body between them. In the male the genital tubercle forms the penis ; the edges of the genital furrow grow together, form- ing the urethra ; and the genital folds form the scrotum and peri- neum. The line of coalescence is elevated above the surroundings, forming the raphe, which extends from the anus to the meatus urin- arius. In the open condition, which continues until the eleventh or twelfth week, the external genital parts are alike in both sexes, and resemble very much the advanced female organs. Development of the External Sexnal Organs in the Male and the Female from the in- different type : A, the external sexual or- gans in an embryo of about nine weeks, in which external sexiial distinction is not yet established, and the cloaca still exists; B, the same in an embryo some- what more advanced, and in which, with- out marked sexual distinction, the anus is now separated from the urogenital aperture ; C, the same in an embryo of about ten weeks, showing the female type ; D, the same in a male embryo some- what more advanced ; pc, common blas- tema of penis and clitoris or genital tuber- cle (to the right of these letters in Fig. A is seen the umbilical cord); p, penis; c, clitoris ; cl, cloacal opening ; vp. urogenital opening ; a, anus : Is, cutaneous elevation which becomes the labia or the scrotum, genital folds; I, labium; .s, scrotum; co, caudal or coccygeal elevation (Ecker). PART 11. ANATOMY.i Division. — The genitals are divided into two groups : the external genitals, which are organs of copulation ; and the internal, which are organs of reproduction. To the external genitals belong the mons Veneris, the vulva, and the vagina; to the internal, the uterus, the Fallopian tubes, and the ovaries. The Mons Veneris. The mons Veneris (Venus' mount) is the lowest part of the anterior abdominal wall, and the only part of the genitals that is visible when the woman stands erect. It has somewhat the shape of a trapezoid, and is limited above by a transverse sulcus that separates it from the hypogastric region, on the sides by the inguinal folds, and below it is continuous with the labia majora. It lies in front of the pubic bones and the lower end of the abdominal muscles. It has a convex surface, and falls gently off toward the surrounding parts. It consists of skin, adipose tissue, with many interwoven fibrous and elastic bands, and i)art of the common superficial fascia. It is rich in nervous fibrils. The skin is coarse, has many sebaceous glands, and is covered by a growth of coarse hair, which is limited by a straight or convex upper line (Fig. 28), and does not extend up to the umbilicus, as in man. It is in most women curly, and darker than the hair of the head. This growth appears about puberty. Function. — During copulation these hairs come in contact with the corresponding growth of the other sex, and by the irritation thus ' Those who wish further information than tliat warranted by the limits of this work are referred to the excellent articles by Henry C. Coe in the Si/Htrm of (ii/ne- colof/y, and Ambrose L. Kannev, Am. Jour. Ob.'itetrics, March, April, ^lay, June, 1883. My own special investigations on anatomical questions are found incorporated in the following pajiers: " Gastro-elytrotomy," A. Y. Med. Jour., Oct. and Nov., 1S78; "The Obstetric Treatment of the Perineum," ^h). ./owe. O/w/., April, 1880; "Rest 36 DISEASES OF WOMEN. caused in the nerves at their root give a pleasurable sensation. The vessels and nerves come from the same sources as those of the vulva (see below). The Vulva. The vulva (Fig. 28) forms and surrounds the entrance to the genital canal. The following organs compose it : The labia majora, with the four- chette; the labia minora, with the ^^"- ^^- clitoris ; the vestibule, with the bulbs ; ^ ^«=*sssfs^^iiis^'p^^ the fossa navicularis ; and the vulvo- II vaginal glands. ;^|g^ ^jy; The labia majora (larger lips, Fig. **"'^^^^ ^ ^^' '^^ ^^^ ^^^ prominent ridges, one l^y ^^k ^^ either side of the median line. A MIk \im&^ transverse incision shows a triangular ^ "^S^'-' flUm ' ^^^ surface. They are situated in front J '^F , j UmRSjl "^sM : ^f the descending ramus of the pubes ^ ' ''^ "J ^M ^^Ir^ J^B ^^*^ t^i^ ascending ramus of the 6- ^ WW'T^ml^ "^^fc ischium. Theouter surface is convex, ^ M( IILJ^b I ^^^: ^^ darker color than the rest of the ^ ^ ^ ^^B ^Wp ^KH skin, covered with a continuation of 8-- ■' " ■ ^- ^^^^ '' ^Wii the hair on the mons Veneris, and has ft^ZZZ3^r-%g^£^^ ^^"'111: numerous and large sebaceous and - ' ^rm^^^^i ^^ sudoriferous glands. The inner sur- i^tai'llii' *^' ' ■-■■ "^^^ ^'^ rose-colored, and forms a transi- ii iJlllli ii i tion from skin to mucous membrane, tt / ' '''wJMB lr ' having the same glands as the outer Jij/I II^^M^m '1 surface, and even a few downy hairs. ^^^Br ^^W^IN^^-^ "^^^ place where they unite anteriorly ■..,:^^^^ ^^^^^^^: is called the anterior commissure, and Virginal Vulva: 1, labia majora; 2, 4.},p r>lopp wliprp thpv iinitp lipln'nrl i<* fourchette; 3, labia minora; 4, glans '^"^ pjace Wneie luey uniie ueuinu IS ciitoridis ; 5, meatus urinarius ; 6, ves- called the posterior commisswe. Here tibule; 7, entrance to the vagina ; 8, , . -f, ji • i i hymen; 9, orifice of Bartholin's the tlSSUe bcCOmeS VCrv thin by the f;lanci; 10, anterior commissure of j- v j-i r "i \ • 'i £• abia majora; 11, anus; 12, blind re- disappearance of the fat which forms cess; 13, fossa navicularis; 14, body „ (yrpnt r^nrf nf thp Inhin mninrn Thn«5 of clitoris (modified from Tarnier). ^ gieai parr 01 tne laoia majoia. ±nus a thin fold is formed called the four- chette. Exceptionally, the fourchette is a continuation of the labia minora. Its lower surface consists of skin which has a dark color, similar to that of the external surface of the labia, while its u})per surface is pink, and looks like mucous membrane. In the adult nul- liparous woman the lower edges of the labia majora are in contact, cover all the other parts of the vulva, and form a line running in an antero-posterior direction and called rima pudendi. In the new-born child, in whom the labia majora are incompletely developed, the labia ANA TOMY. 37 minora protrude between them ; and when by childbirth or age the labia majora become flaccid and gape, the labia minora, the entrance to the vagina, and even part of that canal itself, become visible. The structure of the labia majora is similar to that of the mons Veneris, but presents some peculiar features. Immediately under the skin forming the outer surface is found a layer of unstriped mus- cular fibres, which has been called woman's dartos. Under the dartos is found a layer of adipose and connective tissue, and under that, again, a pear-shaped sac called Broca's pouch, or the pudendal sac, attached with its mouth to the external inguinal ring, and extending with its broad part to the perineum, with the superficial fascia of which it coalesces. This pouch is composed of elastic fibres, and contains connective tissue and fat. Occasionally the prolongation of the peritoneum called the canal of Nuck, which accompanies the round ligament of the uterus, is found in it. Function. — The labia majora protect the deejier parts, lead the male organ to them, and serve as buffers durino- coition. The Labia Minora (small lips) or Xipnpha'. — These are two small folds of skin (Fig. 28, 3) of the same dark color as the outside of the labia majora and the fourchette. They present a triangular surface when cut at right angles, having an outer and an inner free surface and a lower edge. At the anterior end they separate into two layers, the lower layer fastening itself to the lower surface of the glans cli- toridis, forming its frenulnm, and the upper ]>assing above the clitoris, forming \ts prepuce. The extension backward of the labia minora varies very much. In some women they go back to the middle line, so as to form a complete ring inside of that formed by the labia majora. In others they do not even reach the level of the meatus urinarius. In most women they extend back about halfway between the clitoris and the posterior commissure. At the base of the inside is a more or less well-marked whitish line, which forms the limit between the skin and the mucous membrane. Their length from the base to the free edge varies likewise very much. In all the women of the Bushmen in South Africa and in some of the Hottentot women they hang halfway down to the knees, forming the so-called Hottentot apron. The labia minora are covered with several layers of ej)idermic cells. Ijeneath the epidermis they are composed of connective tissue, elastic fibres, and smooth muscular fibres, and contain large venous plexuses. They have no hairs nor i'at, but numerous sebaceous glands and papillae containing bulb-shaped terminal organs of nerves. Function. — Their physiological significance seems to be to ensure more perfect adaptation and to a(!t as an irritant for the nerves of the male member at the same time that th(;ir own nerves are acited on. During pregnancy they participate in the general softening of the parturient canal, and by becoming to some extent unlolded during the passage of the child, they facilitate labor. 38 DISEASES OF WOMEN. The Clitoris. — This corresponds to the penis in the male, but the urethra and the corpus spongiosum are separated from it. It is a small cylindrical body about an inch long, placed in the median line, below the anterior commissure, and running in an antero-posterior direction. It is divided into the glans, the body, and the crura. The glans (Fig. 28, 4) is a roundish or pointed tubercle which forms the end of the clitoris. It is the only part of it that is visible, and even that in many women only on pulling the prepuce back. It is cov- ered with mucous membrane, and has a prepuce and frenulum formed by the labia minora. The body (Fig. 28, 14) is surrounded by a fibrous sheath, and consists of two corpora cavernosa separated by an incomplete pectlniform septum. These corpora cavernosa consist of fibrous trabecular, elastic fibres, unstriped muscular fibres, and venous plexuses, with numerous anastomoses. The body is attaclied to the anterior surface of the symphysis pubis by the suspensory liga- ment. Arrived at the pubic arch, the body separates into two crura (Fig. 29), small fibrous cylinders attached to the rami of the pubes Fig. 29. Front View of the Perineal Septum, showing entire clitoris : 1, glans ; 2, suspensory ligament ; 3, crura of clitoris; 4, subpubic ligament; o, dorsal vein of clitoris; 6, perineal septum (Savage's name for the deep perineal fascia or triangular ligament) ; 7, superficial trans- verse muscle; u, meatus urinarius ; v, vagina ; P, site of perineal body (Savage). and the ischium. They are covered by the erector clitoridis muscle, which has its origin on the tuberosity of the ischium and is inserted on the crura, where tiiey unite. Blood-vessels. — The clitoris is an erectile organ, with helicine (spi- ral) arteries and numerous anastomosing veins. It receives the two end branches of the internal pudic artery, the dorsal artery, running on the upper surface, and the artery of the corpus cavernosum in the depth of that body. The veins go to the dorsal vein, running in the The Nerves of the Pelvis : A, abdominal aorta ; B, lumbar vertebrae with intervertebral disks ; C, the right portion of the sacrum sawn after removal of os innominatum ; D, ureter; E, pyriformis muscle cut at its exit from the pelvic cavity; F, the curve of the rectum, cor- responding to the anterior surface of the sacrum ; H, virginal uterus feebly developed ; K, right ovary displaced somewhat upward; L, bladder; M, levator ani muscle, cut in part; N, ischio-cavernosus muscle; O, corpus cavernosum clitoridis, joining on the other side the clitoris, covered with nerve-filaments; P, symphysis pubis (the whole body being inclined forward, it has become horizontal) ; T, fimbriated end of Fallopian tube ; 1, Lumbar nerves, passing out of the intervertebral foramina to form the lumbar plexus ; the lower lumbar and the upper sacral nerves joining to form the sacral plexus in front of the pyriformis muscle ; 3, gluteal nerves cut ; the pudic nerve springing by several roots from the plexus formed by the lower sacral nerves ; 5, fine twigs passing from the pudic nerve to the ischio-cavernosus muscle; the main trunk goes under the syniphy^'is, and ends as the dorsal nen'e of the clitoris (21) ; 6, branches of communication which carry sympathetic twigs to the spinal nerves and spinal twigs to the hypogastric plexus of the sympathetic; 7, principal trunk of the sympathetic in front of the lumbar vertebrse ; 8, continuation of the sympathetic in front of the sacrum ; 9, aortic plexus ; 10, hemorrhoidal plexus, following the arteries of the same name ; 11, superior hypogastric plexus, or ilio-hypogastric plejcus, which receives many spinal and sympathetic branches ; 12, inferior hypogastric plexus, com- municating with 13, anterior sacral plexus, made up of spinal and sympathetic branches; 14, from the many ganglia placed in this plexus it has a network appearance ; 15, inferior rectal twigs, which pass down even to the sphincter, where they form a network covered by the levator ani ; 16, vaginal plexus; 17, that part of the inferior hypogastric plexus in the shape of a fine network at the upper end of the vagina gives branches to the bladder, the Fallopian tube, and the clitoris ; 18, nerve-twigs which run on the side wall of the uterus (giving branches to it) upward to the Fallopian tube and ovary, where they join the nerves following the ovarian artery, which correspond to the spermatic plexus in man ; 19, vesical nerves; 20, uterine plexus; 21, dorsal nerve of clitoris, which joins with the cav- ernous plexus of the clitoris from the sympathetic to the glans clitoridis (Rydygier). Fig. 30. ANATOMY. 39 middle line between the two arteries, and ending in the pudic plexus, which surrounds the upper part of the urethra. Those of the glans commui^ioate with the bulbus vaginge. The lymphatics go to the superficial inguinal glands. Nerves. — The clitoris has a rich nerve-supply (Fig. 30) from the dorsal nerve of the clitoris, a branch of the pudic nerve, and from the sympathetic, which form a kind of nervous sheath round the glans, with a peculiar kind of end-bulbs called genital corpuscles. Function. — The clitoris is the chief seat of sexual excitement in women, and therefore often the object of masturbation. During coition it is enlarged, arched, and the glans is pressed against the dorsum penis. The vestibule (Fig. 28, 6) is the triangular space between the clit- oris, the labia minora, and the entrance to the vagina. It corre- sponds to the urogenital sinus of the embryo. In the middle line we have the meatus urinarius, which in most women forms a small isos- celes triangle, with the base turned back toward the vaginal entrance, from which it is about a quarter of an inch distant, while the distance from the clitoris is about three times as long. On either side of this opening, just inside of the labia minora, is a deep blind recess (Fig. 28, 12j. As these recesses are always plainly visible, and the urethral opening sometimes does not appear, the former become valuable land- marks in catheterization. By placing the catheter just midway between the two blind sacs we cannot miss the urethra. In cathe- terization under cover the tip of the forefinger is introduced into the vagina, the bulb toward the urethra ; the catheter is slid along the median line of the finger until it reaches the vestibule, and then raised a quarter of an inch. There are many other smaller depressions, both in the recesses and in other parts of the vestil)ule, which are the oj)enings of compound racemose glands {glandulce vestibulares minores) that secrete a mucous fluid. Sebaceous glands are absent. The vestibulo-vaginal bulbs (Fig. 31) are two leech-shaj)ed organs, one on either side of the vestibule and the entrance to the vagina. Together they are equivalent to the bulb of the urethra in the male. The posterior end is round, and reaches back toward the posterior part of the vaginal orifice, where it is in contact with the vulvo-vaginal gland, and partly covers it. The anterior end is thinner, and nearly reaches the clitoris. It lies under tiie nuicous membrane and tiie superficial fascia of tlie ])erineum, and inside of the sphincter vaginae muscle. It consists of a fibrous sheath, and inside of that numerous veins from the internal pudic, complicated venous plexuses, some nerves, mostly belonging to the sympathetic system, unstriped nuis- cular fibres, and connective tissue. The veins have numerous com- munications with those of tlu; surrounding parts. Near the anterior eiid f)f the bulbs they go from one side to the other, miiting the two 40 DISEASES OF WOMEN. both behind and in front of the meatus urinarius, forming the joars intermedia, and from here they communicate with the corpora cav- ernosa of the clitoris. The fossa tiavicularis is that part of the vulva situated between the vaginal entrance in front and the fourchette behind, and limited on the sides by the labia majora and above by the perineal body. It Fig. 31 . Front View of the External Erectile Organs : a, vestibulo-vaginal bulb ; b, sphincter vaginse muscle; ce, pars intermedia; /, ghxns clitoridis; g. connecting veins; h, dorsal vein of the clitoris; k, veins passing behind the pubes ; I, obturator vein (Kobelt). The bulbs are over-distended with injection-fluid and reach too far back. does not exist as a hollow wlieu the labia majora are in contact. It is first formed, and gets its boat-shape when they are separated from each other. On stretching them from side to side we see the pos- terior commissure advance until it reaches the level of the posterior border of the entrance to the vagina. Thus a fold and a hollow are formed. The fold is the fourchette ; the hollow is the fossa navicularis. In virgins the fourchette projects a little forward, even Avithout stretching, but in women who have had frequent intercourse it becomes so lax that the projection is lost or much diminished. During child- birth it is often torn. The lining membrane of this fossa seems to make a transition from skin to mucous membrane. Function. — The vestibule and fossa navicularis form together one cavity, which, lying deeper {i. e. higher up in the erect posture) than tlie surroundings, and being conifurm, in connection with the larger space formed by the labia majora, lead the entering member of copu- lation to the entrance of the vagina. The vulvo-vaginal glands, or BarthoVui's glands (Fig. 32, b), are two small oval bodies, from the si/.e of a bean to that of an almond, situated one on either side of the entrance to the vagina close up to the posterior end of the vestibulo-vaginal bulb, in front of the superficial ANATOMY. 41 Fig. 32. transversus perinsei muscle, and between the posterior third of the side of the vaginal entrance and the erector clitoridis muscle. They lie between the two layers of the deep perineal fascia, or sometimes under (i. e., above in the erect posture) the deep layer.' They are compound racemose glands, se- creting a mucous fluid, just like the smaller glands of the vestibule, and are sometimes called glandulce vestibulares majores. Their excretory duct opens with a minute aperture just in front and out- side of the hymen, on the inside of the labia majora, or labia minora if these ex- tend so far back. They contribute to the lubrication of the vulva, especially when pressed upon by the surrounding muscles during sexual excitement. In the erect posture the vulva is hidden between the thighs. Wlien not artificially spread out, the two lateral halves are in contact in the normal adult woman. The vulva receives its arteries from the superficial jierineal branch of the internal pudic and the external pudic arteries com- ing from the femoral. The veins accom- pany the arteries. On account of the free communications between themselves and with those of the pelvis even a small wound of the vulva, especially when during pregnancy they swell, may cause dangerous or even fatal venous hemorrhage. The lymphatics open into the superficial inguinal glands, which are in communication with the deep inguinal glands and external iliac glands. The nerves come from the superficial perineal nerve, which is a branch of the pudic, the inferior jiudendal nerve, which is a branch of the small sciatic nerve, and from the pelvic, or inferior hypogastric, plexus of the sympathetic nerve. Special features of the vessels and nerves of the clitoris and the bulbs of the vestibule have been treated under the descriptions of those organs. The Vagina. Until within a few years all descriptions and drawings of the vagina gave a very erroneous idea of this organ. It is a slit in the pelvic floor (Fig. 33, A), having a slanting direction from above and ' Ambrose L. Ranney found in every rase Bartholin's glands lying posterior to triangular ligament ("The Female Perineum," N. Y. Med. Jour., July-August, 1882, vol. xxxvl. p. 45). Vulvo-vaginal Gland. Thelabium majus and minu.s, the sphincter vaginae muscle, and the bulb have been partly removed on the right side in order to expose the gland : AA', section of labium majus and minus; B, gland; C, excretory duct ; C, stylet intro- duced into the duct; D, glandu- lar end of duct ; E, free end of duct ; F, section of bulb ; O, as- cending ramus of ischium (Hu- guier). 42 DISEASES OF WOMEN. behind downward and forwaixl, at an angle of 60° with the horizon, situated between the bladder and the urethra in front and the rectum Fig. 33. Sagittal Section of Pelvis (Waldeyer): a, symphysis pubis; b, bladder; c, small intestine; d, large intestine; e, anus ; /, perineal Dody ; g, vulva ; h, vagina; i, uterus. behind, and extending from the vulva below to the uterus above. It has a slight curve with the concavity forward, correspouding to the shape of the male member when in erection — a curve which is much increased during parturition, when the child rounds the symphysis pubis. When distended it has the shape of a truncated cone with the apex at the vulva and the base at the uterus ; but when not dis- tended it is folded together in such a way that the slit on a cross- section has somewhat the shape of the letter H, the anterior and posterior wall being in contact in the middle, and each side wall being folded against itself at the ends (Fig. 34, vo). At the lower end it dips into the vulva, forming the hymen, in the same way as at the upper end the uterus dips into the vagina, forming the vaginal por- tion. At the upper end it forms a cup, adapting itself closely to the vaginal portion of the uterus, as does the cup to the ball of the toy called "bilboquet" or "cup and ball." The ujiper, broader end is called the roof or fornix, and in its adaj^tation to the vaginal portion it forms a shallow pouch in front and a much deeper behind, united by side pouches, forming an even transition from one to the other. The lower end, when we remove the hymen (which will be considered later), forms a circular opening, surrounded by the constrictor vaginae muscle. ANATOMY. 43 In olden times authors, just as the laity often do yet, comprised the whole parturient canal under the term " womb " or uterus. Now the profession has learned to distinguish the womb from the vagina, but the latter is yet in obstetrical and gynecological language fre- quently confounded with the vulva. We must, therefore, expressly call attention to the limits between these two parts of the parturient canal, and tiie difference between the two openings at its beginning. The entrance to the vulva is formetl by the rima pudendi, a slit in the skin running in a straight line, in an antero-posterior direction ; the en- trance to the vagina lies an inch or two deeper, is circular, surrounded by mu- cous membrane and muscles, and is marked by the hymen or its remnants. The size of the vagina varies enor- mously in different individuals and dif- ferent conditions. In the adult virgin the anterior wall is about 2 inches, the posterior about 2i inches long, and the width near the upper end about Ih inciies. By coition, and especially child- birth, these dimensions are much in- creased. During copulation it has the size of the body that distends it. Dur- ing pregnancy great proliferation of tis- sue, swelling of veins, and serous infil- tration take place, so that at the time of delivery the canal not only is wide enough to let the child pa&s, but be- comes so elongated that it can accom- pany the child far beyond the limits of the outlet of the bony pelvis. The vagina is composed (Figs. 35, 3G) of an outer sheath of con- nective tissue, containing fat, a muscular layer with longitudinal and transverse fibres, and a mucous membrane with flat epithelium. The muscular fibres can be followed to the posterior surface of the pubic bone and the anterior surface of the sacro-iliac articulation (Rouget). In the j)erineal region the muscle-fibres reach the bone between the two layers of the triangular ligament. The mucous membrane forms on the anterior wall a longitudinal ridge in or near the median line, from which folds, so-called rur/ce, go out to the sides, like the teeth of a comb ; a similar but less distinct formation is found on the posterior wall. They are called the (Ulterior and posterior rohdnu.s. The anterior often ends below in a round protuberance, called the tubercle of the vaf/iua, which is situated inunediatcly behind the meatus urinarius. Often the anterior column is divided bv a lon- Horizontal Section of the Soft Parts in the Inferior Strait of the Pelvis (Henle) : I'u, vagina ; Lr. urethra; H, rectum ; L, levator ani. 44 DISEASES OF WOMEN. gitudinal furrow into two halves. The rugae are covered with micro- scopical papillae. The columns and the rugae disappear in the upper part of the vagina. They are organs of sexual excitement, and cou- FiG. 35. Fig. 36. Fig. 35.— Longitudinal Section of the Posterior Wall of the Vagina of a girl twenty-four years old. Fig. 36.— Transverse Section of the Same (Breisky) : a, mucous membrane; b, muscular layer, with a, circular, and p, longitudinal fibres; c, fibrous layer containing adipose tissue. tribute probably to the eulargement of the vagina during pregnancy and childbirth. After the latter they are much less prominent or disappear entirely. Tiie presence o^ glands in the mucous membrane is disputed.' The vagina posses.ses the power of absorption. This faculty is in- creased in pregnant, puerperal, and feverish women. ^ The vagina has a rich vascular su])ply. The arteries (Fig. 37) come from the anterior division of the internal iliac or one of its branches, the vaginal, the uterine, the vesical, the middle hemorrhoidal, and the 1 In a woman in the fifth month of pre<,Miancy I have seen the whole vagina red and full of openings like a tonsil, out of which a solid yellowish discharge could be pressed. I do not see what these openings could have been except entrances to glandular follicles. ^ Coen and Levi : Centralblatt fur Gyndkolorjie, 1894, No. 49, p. 1261. P o :« 3- -^ ►^ £ ^ " ,-f O C ^ ^ S."" 5 tr o ra < s. JQ rs H 2" — 3" ^. ^' c c D- SO -1 a p 3. ^ ZT 5 s 5" re S 2. ra 2 m ^ a — o- 2 P <l: :^ ^ _ O s 3 t3' - o' H> Oi 2, ifT 2 3* S"< D- S S' r-^ «j=i 2 P - "-^ o- o s S '^ t^ - 'i{^ '^ ^ £.-^ c-j ANATOMY. 45 internal pudic. There are two or three vaginal artories on either side, which anastomose with the circular artery of the uterus, and form a perpendicular branch in the median line, back and front, called the azygos artery of the vagina. The veins form a dense network (Fig. 38), and communicate with those of the vulva, the bladder, the rectum, tlic uterus, and the broad ligament. Finally, the blood is carried to the internal iliac veins. The lymphatics from the lower tliird, go to the superficial inguinal glands, as do those from the vulva ; those from the middle third Fig. 38. The Venous Plexuses of the Vaprina and the Vulva, as seen in mesial section (Savage) : B, bladder partially inflated ; h, ureter : V. vagina ; P, section of pubcs ; /?, rectum ; C, clitoris ; 1, bulb; 2, its urethral process; 3, lower efferent veins; 4, dorsal vein of the clitoris; 5, urethral venous plexus: 6. commencement of vaginal venous plexus; 7, 8, 9, 10, sciatic and gluteal veins; il, uterine veins; 12, obturator vein; 13, internal iliac vein; a, pyri- formis muscle; 6, greater sacro-sciatic ligament; c, levator ani and eoccygeus muscles; d, OS eoecygis; e, suspensory ligament of clitoris; i-; vulvo-vaginal gland; ggg roots of sacral plexus of nerves. form two trunks, which follow oue of the vaginal arteries to one or two glands situated between the rectum and the sciatic nerve, near the origin of the vaginal, hypogastric, and internal ptidic arteries, on a level with the middU; part of the great sciatic notch. Tiicy con- stitute the lowest of the internal iliac glands. The lyin])liaties from the upper third of the vagina combine with those from the cervix The nrn^fts (Fig. 30) come from the syinj)athetic, and form a vaginal » Poirier, Progris Medical, 1889, Nof*. 47, 48, 49, ol, and 1890, Nos. .'i, 4. 46 DISEASES OF WOMEN. plexus on either side of tlie vagina, communicating with the inferior hypogastric. Their final fibrillae terminate in end-bulbs. Function. — The vagina has a triple physiological function. Dur- ing copulation it receives the penis, and during parturition it helps move the child forward along tlie curve of Cams. To this must be added the power of the normal vaginal secretion to kill bacteria and thus protect the woman against the numerous cocci and bacilli that in various ways find entrance into the vagina. Even when pyo- genic staphylococci and streptococci are introduced experimentally into the vagina, they disappear within two days. The vagina can become distended independently of the introduction of any distending solid body or air-pressure, which, works when the patient is examined in the knee-chest or Sims's position. This must be due to the con- traction of the muscular fibres that are attached to the pelvic bones. I have often found this ballooning during examinations with a single finger with the patient lying on her back, and in nulliparae with a tight vaginal entrance. The same applies to the rectum. The Hymen. The hymen begins, as we have seen in the history of the develop- ment, as a protuberance from the posterior wall of the vagina. It is a fold of the mucous membrane containing elastic fibres, blood-vessels, lymph- vessels, nerves, and sometimes smooth muscular fibres. It closes the vagina more or less completely, and varies much in shape, but in most ca.ses it is more developed behind than in front. The Fig. 40. Fig. 39. illi |i^'""" pp/" Hymen with Linear Opening (Tardien). Annular Hymen (Tardieu). most common shape, especially in childhood, is that of a strip of tissue bent so as to form two lateral halves touching each other in a ANATOMY. 47 straight middle line (Fig. 39). In other cases it forms a ring with a round opening (Fig. 40). In others, again, it has the shape of a crescent (Fig. 41). Often the border is indented (Fig. 42), a form that is easily distinguished from a lacerated hymen by the softness of the tissues, the absence of cicatrices, the round contour of the tongues, and, above all, by the decided resistance that is felt in trying to pass the finger. Sometimes the hymen is only represented by a low circu- lar or crescentic ridge. The u])per surface shows a continuation of the rugfle of the vagina, of whicii it only forms the lowest, thinned part, somewhat in the manner of the relation between the fourchette and the posterior end of the labia majora. The hymen is, as a rule, torn by the first successful coition, into two or three, rarely a greater number of flajis, but there is no loss of substance. By putting the flaps in contact we can reproduce its Driginal shape. In childbirth, on the contrary, it suffers so much that only three or four roundish prominences are left of it, the so-called carunculoe myiiijorvies. In a strictly intact vulva considerable resistance is felt, and pain is caused by the examining finger, be it at the opening of the hymen or at its base, where it joins the rest of the vagina. An easy accessi- FiG. 4L Fig. 42. Crescent-shaped Hymen (Tardieu). Indented Hymen. bility to the vagina without laceration of the hymen is due to a gradual dilatation l)y a comparatively small body. It must be borne in mind tliat this not always means mastiirbation. It may be the result of carci'ui gynecological treatment, while a careless examination may ru])ture the membrane, producing a result similar to that of coition. 48 DISEASES OF WOMEN. It has been asserted that there is a folding or yielding kind of hymen, which folds back when a specuhim is introduced or during copulation. I think this can only be the effect of gradual dilata- tion. Some pretend that such a pliable hymen goes unscathed even through child-birth — a statement so entirely at variance with the common experience that its accuracy seems doubtful. The Uterus. The items (Fig. 43) is a hollow body with thick muscular walls situated between the vagina below and the small intestines above, the bladder in front, and the rectum behind. It has somewhat the shape of a flattened pear, and may be divided into two parts, called the neck, or cervix, and the body, or coi'piis. A subdivision of the neck is the vaginal po7'tio7i (Fig. 43, A, a), which dips into the vagina; and Virgin Uterus, natural size (Sappey) : A, front view : the appendages and the vagina are cut away ; a, vaginal portion of cervix ; b, isthmus ; c, body. B, the same in vertical mesial section : a, anterior surface ; the letter is placed a little above the bottom of the vesico-uterine pouch. C, the same with cavity exposed by coronal section : e, os externum ; d, os internum ; /, fundus, the letter placed just above uterine opening of Fallopian tube. a subdivision of the body is the fundus (Fig. 43, C,f), whicli lies above the entrance of the Fallopian tubes. The neck is cylindrical or rather barrel-shaped, being thicker in the middle than at the ends, and the line of demarkation between it and the body is marked out- side, on its anterior surface, by the fold formed by the peritoneum when from the uterus it passes to the bladder. ANATOMY. 49 The vaginal portion or infravaginal 'part of the cei'vix forms a rounded cone nearly one-half inch high, on the top of which is found a transverse slit measuring about one-quarter of an inch from side to side, and called the os externum, os tincce (i. e. the mouth of a tench), or simply the os uteri. If we imagine this opening prolonged so as to divide the cervical portion into two halves, the anterior is called the anterior lip, and the posterior the posterior lip — a condi- tion that often is produced by childbirth, but then is pathological. The anterior lip di])S lower down than the posterior, but the pouch formed by the vagina being much deeper behind than in front (Fig. 43, B) the posterior lip goes much higher up, so that it is longer than the anterior, 'i'he vaginal portion is covered with a smooth mucous membrane with flat epithelium, like that of the vagina. The supravaginal part of the neck is about -J inch long, and is bound with rather loose connective tissue to the bladder in front, and on the sides to the mass forming tiie base of the broad ligaments of the uterus, and called the parametrium. Behind, it is free, being separated from the rectum by a ])art of the peritoneal cavity called Douglas's pouch. The body of the uterus, in the more restricted sense of the word, is triangular. It forms a flattened truncated cone, with the end turned down to the cervix and the base up to the fundus. The sides are a little convex (Fig. 43, ^1). The anterior surface is convex from side to side, and straight or slightly concave from above downward. The posterior surface is strongly convex in all directions. The fun- dus is moderately convex from side to side, and much more so from the anterior to the posterior surface (Fig. 43, B and C). The interior of the womb contains a cavity (Fig. 43, B and C), the anterior and posterior walls of which are in contact. It is 2 inches long in the nulliparous woman, and is divided into three parts, the cervical canal., the isthmus, and tiie cavifij of the bodij. The cervical canal is about 1 inch long, is spindle-shaped, and on the anterior and ])osterior wall there is found a longitudinal ridge from which branches go out- ward and upward, se])arated by deep pouches. The whole Ibrmatiou is called arbor vita'., iiahiuv. plicatcc, or plicce pahnatai. The isthmus, or OS interuuui, is the narrowest j)art of the cavity, r.early cylindrical, about \ inch long and ^- inch in diameter. The median ridge of the arbor vitcn extends to its uj)j)er end. The cavity of the body is tri- angular, with curved sides bulging into the cavity and smooth sur- faces. At the two upper angles are fbiuid the uterine apertures of the Fallopian tubes. The wall is about ^ of an in(;h thick in the thickest parts, which are the middle of the edges of the body, the; middle of the fundus, and th(! middle of the cervix. It is thinnest at the entrances to the Fallopian tubes and at the external os. 4 50 DISEASES OF WOMEN. The size of the womb increases somewhat by sexual intercourse, and still more by childbirth. The length measures in virgins 2 to 2^ inches, in nullipane 2 to 2| inches, in multiparae 2^ to 3 inches. The width on the level of the Fallopian tubes, the broadest part, is in virgins 1^ to If, in nulliparae the same, in multiparse 1^ to 2 inches. The thickness is about the same in all three classes, varying from -^ of an inch to 1|^ inches. The cervix is about l^^- inches from side to side in the middle, and a little less at the ends. Fig. 44. Vertical Section through the Mucous Membrane of the Human Uterus (Turner) : e, columnar epithelium ; the cilia are not represented ; g,g, utricular glands ; ct, interglandular con- nective tissue ; v,v, blood-vessels ; mm, muscular layer. The body is only a little longer than the neck in nulliparae ; in those who have borne children it becomes three-fifths or two-thirds of the length of the whole organ. The wall is composed of three layers — a serous, a muscular, and a mucous. The serous coat is formed by the peritoneum, and does not cover the anterior surface and the sides of the cervix. The muscular part of the wall may be divided into three layers, which become distinct during pregnancy : an outer longitudinal layer, which sends prolongations into the round and the ovarian ligaments. ANATOMY. 51 il^lirt the tubes, and the sacro-uterine ligaments ; a middle layer of inter- lacing longitudinal and transverse fibres, which is in connection with the muscular coat of the vagina ; and an internal transverse layer, which is especially developed in what was formerly the two horns, and near the internal os, in which lat- ter place it forms a sphincter. It enters also the folds of the plicae pal- raatse. The middle layer is the thick- est and contains the vessels. The mucous membrane (Fig. 44) lines the whole cavity. In the body it is thin and intimately connected with the muscular layer, bundles of the muscles and connective tissue ex- tending from one to the other. When fresh it is pink. It consists of fine threads of connective tissue and round or oblong cells (Figs. 45 and 46), and is perforated by numerous tubes, com- posed of a basement membrane and a layer of ciliated columnar epithelium, and called the utricular glands. They have a general direction parallel to one another, but are tortuous, and have often two or three branches in the deeper parts of the mucous membrane.* In the" cervix the mucous membrane is thicker, is composed of fibrous connective tissue without adenoid structure, has racemose glands, and is separated from tlie muscular layer by a distinct sub- mucous layer of looser connective tissue. The epithelium is col- umnar and ciliated on the free surface of the body,^ in tlie utricular glands, and on the edges of tlie branches of the arbor vita?. In the ^ According to Dr. Arthur W. .Johnstone of Danville, Ky., the mucous membrane is an adenoid tissue, like that of the tonsils, the tliyroid body, the spleen, the thy- mus, the lymphatic glands, and the lymph-tiss>ies in the wall of the alimentary canal. The cells originate as granules in the fibres. They are only found between the age of puberty and the climacteric {Trans. Brit. Med. Soc, June 23, 1886). * Having stated elsewhere that the epithelium of the body was columnar without cilia — a view shared by such an authority on the microscopical anatomy of the female genitals a-s De Sinety (Manuel pratiijite de Gynerolof/te, Paris, 1879, [). 239) — and having been told that I was wrong, I addressed Dr. .Johnstone on the subject, who recently has made a special study of the mucous membrane of the uterus. He answered: "The cause of the diflerence of opinion is that the ei)ithelium on the free surface of the corporeal endometrium is shed every twenty-eight days, and the difU'r- ent observers have each described a diflerent stage of its regeneration. I have seen it in all conditions, from a simple round cell up to a fully-developed colimniar e])ithelium, and in a few inst'inces have seen what looked like cilia. Hut before they become perfect the menstrual flow strips off the epithelial coat, and the cycle repeats itself." Section of the Mucous Membrane of the Uterus parallel to the surface, enlarged 150 times (Heiile) : 1, 2, 3, glands (the epithelium has fallen out from 2) ; 4, blood-vessel. 5^ DISEASES OF WOMEN. depressions between them it is goblet-shaped, without cilia. In the glands of the cervix it is cuboidal, without cilia. The direction of the ciliary movement is from the fundus to the os.^ Shape and Position. — Opinions as to the normal shape and posi- tion of the womb differ so nuK;h that it has almost become a con- fession of faith to say anything about it ; but, since I have made gynecological examinations for many years, and have paid special attention to what can be seen and felt in regard to the anatomy of the genitals, I think I may be able to express an opinion that is not Fig. 46. Fibre of Endometrium, showing different degrees of corpuscular development. Enlarged 3000 times (Johnstone). altogether without foundation in facts, as are so many descriptions and drawings given of these parts. We have five sources of informa- tion — viz. dissections of dead bodies, sections of frozen bodies, bimanual palpation of living women, laparotomies, and the devel- opment of the fetus, all of which methods have some advantages and some drawbacks ; but by combining them all I think we get a pretty accurate idea of the true relations. After death, the body lying on its back, the whole pelvic floor, especially in multip- ara, is apt to sink, so that the fundus of the uterus comes to lie considerably deeper than in the living woman,^ and at the same time it falls back toward the sacrum. Thus all descriptions based on autopsies and sections of frozen bodies become unreliable. On the 1 Ludwig Mandl, Centralbl. fur GyndL, 1898, No. 13, p. 327. * According to Sappey, it should lie | incii to 1 inch below the superior strnit. ANATOMY. 53 other hand, examinations of the living do not admit of the same degree of accuracy as those of dead bodies. Epithelial Cells from the Uterus of a Womaii sixty years old. From edge of a plica palmata: a, ciliated columnar cell (rare): b, plain columnar cell (the majority); c, large goblet cells. From the deepest part of the valley between two plicfc palmata: d, small goblet cells. From inner surface of body : e, front view ; /, side view, columnar, non-ciliated ; nucleus situated nearer lower or upper end, and containing one or two nucleoli. Fig. 48. Mesial Section of the Pelvis of a Girl seventeen years old, luilf natural size (Kolliker): ur, ureter opening into blud<ier; ii, vesical opening of uretlira; <■/, clitoris; /;, hymen. The canal of the normal uterus is straight or sliglitly curved, with the concavity turned forward (Fig. 4^), or S-shapcd. Tlie ])re.->en(c 64 DISEASES OF WOMEN. of an angle opening anteriorly, or of a considerable curvature forward, is an abnormal condition called anteflexion, and constitutes, even if it does not give rise to other symptoms, a considerable hindrance to conception. Any kind of backward curvature constitutes the abnor- mal condition called retroflexion. The fundus reaches a little above the brim of the pelvis (Fig. 41)), and lies a little nearer to the right side than to the left. When the rectum and bladder are empty, the longitudinal axis of the womb forms a right or obtuse angle with that of the vagina. A full bladder will tilt the womb back and press it up against the sacrum, and a full rectum presses it forward to- ward the symphysis. The small intestine is regularly found in the Fig. 49. IMagram of a Supposed ^Mesial Section of the Pelvis of a living woman (Foster-Ranney) : a, anal canal; r, rectum; v, vagina; c, clitoris; b, bladder wlien collapsed; u, uterus; d, valve of rectum (Houston) ; 8, symphysis pubis ; 6 ', sacrum ; C, coccyx. upper part of the recto-uterine excavation, not in the lowest, narrow part of it, Douglas's pouch ; it is also found in the vesico-uterine excavation if the bladder contracts in such a M'ay as to form a Y (Fig. 33), but not if it contracts by apposition of its anterior and posterior wall, in which case the womb and the bladder lie close up to each other (Fig. 48). During pregnancv the uteras increases enormously in size, which is especially due to the formation of new muscular cells and enormous increase in size of the old ones. After the menopause the organ shrinks, the cervical portion forms a small protuberance or disa])pears altogether, and the mucous mem- brane of the body loses nearly all its cells and consists of common connective tissue (Fig. oOj. ANATOMY. Fig. 50. 55 Endometrium of Woman sixty years old x 800 (Jolinstone). Fig. 51. Diagram of the I,ie:aniciits <if tlie I'tcrns (Ilodge). 56 DISEASES OF WOMEN. The Ligaments of the Uterus. — There are eight ligaments (Fig. 51) which contribute more or less to determine the position and shape of the uterus : the vesico-uterine in front, the sacro-uterine behind, the broad and the round at the sides. The vesico-utei'ine Ugaments are two small semilunar folds, one on either side of the median line formed by the peritoneum, when from the bladder it passes to the uterus, on the level of the internal os. Fig. 52. Superior View of the Pelvis and its Organs (Savage) : B, bladder; U, uterus (drawn down by loopc); j; Fallopian tubes ; O, ovaries; L, round ligaments ; £r, ureter; a, ovarian vessels, often prominent under their peritoneal covering (the infundibulo-pelvic ligament) ; 8 S, sacro-uterine ligaments. The sacro-uterine ligaments are much larger peritoneal folds, extending from the anterior surface of the second sacral vertebra to the uterus on a level with the os internum. Together they form an oval opening, with the narrow part turned toward the uterus. Their concave inner edge is turned inward toward the rectum (Fig. 62), and forms the upper border of Douglas's pouch. They contain unstriped muscle-fibres, a direct continuation of those of the woml), and have been called the retractor muscles of the uterus (Luschka). Besides, they contain loose and fibrous connective tissue. They form, toijether with the anterior vaginal wall, an elastic beam on wiiich the uterus is suspended.^ They prevent the uterus from being pulled down in the normal condition beyond the entrance to the vagina. Working together with the round ligaments, their shortening produces anteflexion. 1 Frank P. Foster, Trans. Am. Gyn. Soc, 1881, vol. vi. p. 434. ANATOMY. 57 The broad ligaments are two quadrangular folds of the peritoneum, one on either side, situated between the uterus and the pelvic wall, and forming a partition in the true pelvis between an anterior and a posterior pouch. The inner edge is attached to the edge of the uterus, the outer edge to the wall of the pelvis in a line extending Fig. 53. The Right Wall of the Pelvis (Polk): .^.internal ilinc artery; 5, uterine artery; f, ovarian artery ; JJ, course of the ureter, projected on pelvic wail ; JC. line of pelvic attachment of the broad ligament of the uterus in a nullipara ; F, line of attachment of the levator ani, marking the level of the base of the broad ligament. from a point midway between the sacro-iliac articulation and the ilio-pectineal eminence, downward and backward, between the great sacro-sciatic notch and the obturator foramen, to the level of the .'^j)ine of the i.schium (Fig. 5;5). The upper edge is formed by the Fallo])ian tube inward and tlu; infundibulo-pclvic! ligament outward. The lower edge is attached to the mass of connective tissue lying to the side of the cervix, and called paramvtriHiii or jxiravufru' connective tit<Hne. The upj)cr edge is free ; the three other edges are continuous with the peritoneal covering oi" the uterus, the sides and the floor of the pelvis. It is composed of an anterior and a posterior layer. The anterior layer covers the round ligament ; the po.sterior layer contains an opening, in which the l)as(' of the ovary is inserted. Px'lween these two layei's lie loose connective ti.ssue, unstrijK'd muscular fibres, bliKxl-ve.s.'^els, lymphatics, and nerv(!S. 'Hie mu.scular fibres are a continuation of the outer layer of tlie uterine muscular coat, and form 58 DISEASES OF WOMEN. a kind of flat muscle {platysma — Savage) between the uterus, the ovaries, and the tubes, from which a bundle goes along the ovarian artery, up to the vertebral column, called the superior round ligament (Fig. 54, LS). This whole muscular expansion is capable of" producing a kind of erection of the internal genitals, and it is probably also instrumental in adapting the fimbriae of the tube to the ovary during ovulation (Fig. OO). During pregnancy the broad ligaments are dragged upward and backward by the uterus, so that at full term their base lies on a level with the ilio-pectineal line, and extends from the ilio-pectineal emi- nence to the sacro-iliac articulation.^ The broad ligaments allow the uterus to be pushed or bent forward or backward to any extent ; they allow also an excursion upward and downward of two inches in either direction, but they check the movement from side to side some- what; and when the utero-sacral ligaments are cut or have lost their elasticity, the broad ligaments, as well as the pelvic connective tissue, are put on the stretch by ])ulling the uterus down. The round ligaments (Fig. 54, LI) are two cords, one on either side, springing from the anterior surface of the uterus immediately beloAV and in front of the Fallopian tube, and going in a curve first upward and outward, then inward and forward, outside of the bladder, to the internal inguinal ring, then through the inguinal canal, following its lowest and outermost angle, and out through the external ring. Here it breaks up into different strands, ending in the mons Veneris, the symphysis pubis, and the upper end of the labium majus. Some strands are given off to the surrounding parts during the passage through the inguinal canal. The ligament consists of fibrous connective tissue, unstriped mus- cular fibres from the uterus, and striated fibres coming from the transversalis muscle and the pubic spine. The funicular artery, a branch of the superior vesical, runs through its centre and anasto- moses at the upper angle of the uterus with the uterine and the ovarian arteries, and in the labium majus with branches of the ex- ternal pudic artery. The artery is accompanied by veins. The genital branch of the genito-crural nerve lies in front of the liga- ment at the external ring. Other veins and nerves join it from below. At first it lies under the anterior layer of the broad liga- ment. When it leaves the broad ligament it has a peritoneal cover- ing of its own, which, as a rule, stops at the internal ring in the adult. During the fetal life the peritoneum forms a pouch which accompanies it through the inguinal canal, and is called the canal of ^ W. M. Polk, " Landmarks in the 0])eration of Gastro-elytrotomy," N. Y. Med. Jour., May, 1882, vol. XXXV. jip. 449-454; as well as his "Observations upon the Anatomy of the Female Pelvis," ibid., Dec., 1882, vol. xxxvi. pp. 561-569. These papers, based upon original investigation on the bodies of pregnant women, contain most valuable information not to be found anywliere else, to my knowledge. ANATOMY. 59 Nuck, and corresponds to the processus vaginalis in the male. This pouch normally grows together, forming a fibrous cord; but abnor- mally it may persist and give rise to female hydrocele, or be found as a sheath of the ligament in Alexander's operation. (See Retro- flexion of Uterus.) Fig. 54. b The vessels of the vagina and the internal genitals in their relation to the superficial muscu- lar structures (Rouget). The specimen i.s seen from behinfl. Vascular system: VP, vaginal plexus ; PC, cervical plexus ; PU, uterine plexus ; JIJ', helicine arteries of uterine bcxiy; h, helicine arteries of hilum of ovary. Muscular system: 17', insertion of the muscle-bundles of the vagina on the pubes ; VS, bundles of the same muscular coat com- ing from the region of the sacro-iliac articulation; L'S, uterine muscle-bundles which accompany the preceding, and constitute to a great extent the posterior layer of the broad ligament; VP, recto-uterine or sacro-uterine ligaments; J J, inguinal or pubic round ligament, spreading over the whole anterior surface of the uterus ; LO, ovarian ligament ; L>, superior or lumbar round ligament, which accompanies and envelops the internal spermatic, or ovarian vessels; a, muscular bundles coming from the ovarian ligament (7,0), spreading and interlacing with the bundles, 6, coming from the superior or lumbar ligament (LS), in tlie interior of the ovary, and beyond in tlie ala vesperlilionis, liefore they insert themselves on the tube and the fimbriae ; a', bundles starting from tlie ovary, which, together with others coming directly from the superior ligament, form tlie fimbria ovarica. During pregnancy the round ligament becomes finger-tliick. It is only found in women and the higher aj)(;s, who occasionally take the erect position. It contracts when stimulated by electricity like other mu.scles. JJoth ligaments being contracted at the same time they tilt the fundus uteri forward, and as they contract simultaneously with the abdominal muscles, they prevent retroversion from being produced by coughing, lifting, straining at stool, etc' ' J. II. Kellogg, of Battle Creek, IMicli., Tran.'^. Am. Assoc. Obshi. and Cijn., 1889, vol. ii. p. *2GG. 60 DISEASES OF W03IEN. During copulation they produce probably a kind of suction, and by their intimate connection with the muscular platysma of the broad ligament, and working together with the superior round ligament, they cause erection of the inner genital organs. During labor they pull the fundus forward and downward, and thus give it the most favor- able direction in relation to the superior strait. srustomosfs Sagittal section of uterus, showing the scheme of the arterial distribution (Clark). The arteries of the uterus come from three chief sources : tlio uterine artery from the internal iliac ; the ovarian from the aorta ; and the small artery of the round ligament from the superior vesi- cal. The uterine artery starts from the internal iliac about |r of an inch below the brim of the pelvis, goes behind the ])critoncum on the posterior wall of the pelvis, down into the parametrium, and forms a loop in front of tiie ureter, a short distance from the an- terior lateral fornix of the vagina (Fig. 56). (Compare Fig. 53.) Hence it goes up between the two layers of the broad ligament, ANATOMY. 61 following the edge of the uterus to the corner of the same, where it anastomoses with the ovarian artery, one being simply a continuation of the other (Fig. 37, p. 45). It sends numerous branches off at right angles to the uterus, where they anastomose with those from the other side. At the level of the internal os such anastomosing branches in front and behind form the circular artery. In the outer layer of the musculature the arteries have a longitudinal direction, running parallel to one another, but freely anastomosing with one another. From the innermost of these branches others go off at riglit angles, penetrate the dee])er layers of the musculature, supply- Fro. 56. The Uterine Artery in its lU'lntion to the Ureter: a pliotographic reprortuetion of a section of the pelvis, extending from the pectineal eminence above to tlie lesser saero-sciatic fora- men below (l'(jlk). On the right .side the broad ligament has been removed : U. nterus, right side freed of peritoneum: O, ovary ; (', base of bladder sliowing urethral orifice, the organ having been cut away on a level with the utero-vesical peritoneal fold : the doited line running acro.ss its iipper edge corresponds to the ntero-vaginal junction; above this, at F, we have the ctircular artery of the cervix; .1, uterine artery : BB. ureter, with a probe passing through it : />, nvariim artery ; E, round ligament, held up to show the ovary and vessels behind it ; li, rectinn. ing them with numerous anastomosing nutrient vessels, and finally terminate in a rich cajiiliarv network in the endometrium (Fig. 5;")).' Tlie trunk has a very tortuous course, and the branches are wound like corkscrews, Jidicine ayirrics (Fig. 54, JIJ^). These branches have so small a lumen and so thick a mu.-^cular coat that in many cases the whole ut(n'us can be cut loose from the broad ligament witliout using ligatures or elamj)s f(»r arresting hemorrhage. During pregnancy the uterine artery remains comj^aratively small, its calii)re equalling that of the ureter, while the ovarian is much thicker. '.]. (i. Clark, JohuK Ihpkim liulldhi, No. 91, Jan., 1S99. 62 DISEASES OF WOMEN. Besides the six arteries of the uterus described above, it receives the anterior and posterior azygos arteries from the vagina. The uterine veins form a network in the muscular coat, and open into a conglomeration of veins lying at the edges of the uterus. From the middle of this plexus the two uterine veins follow the uterine artery, and oiirry the blood to the internal iliac vein. At its upper end this plexus anastomoses with the branches of the ovarian Fig. 57. The Uterine Veins and the Ureter (Luschka). The bladder being considerably distended, it was cut off sufficiently to show the inner surface of its posterior wall where it is in con- tact with the uterus and the vagina. On tlie right side also part of the posterior wall of the bladder was removed in order to show the course of the ureter on the anterior wall of the vagina. Where the uterus and the vagina are concealed by the bladder their con- tours are marked with heavy black lines: a, anterior surface of uterus, showing how far it is covered with peritoneum when tlie bladder is full ; h, portion of supravaginal part of cervix covered by the bladder ; c, vaginal portion of uterus ; d, vault of vagina ; e, ante- rior wall of vagina; ff, cut surface of bladder-wall; (j, trigone; h, vesical opening of urethra ; i, i, i, venous plexus at the side of the uterus and the vagina ; k, right ureter ; I, left ureter. (Two-thirds natural size.) vein, and below with the vaginal and vesical plexuses. The ureter passes right through it (Fig. 57). During pregnancy the uterine veins are enormously enlarged and form the so-called sinuses, large spaces the walls of which only consist of the internal coat of the veins, and are intimately bound to the surrounding muscular tissue. ANATOMY. 63 The Lymphatics. — The uterus is exceedingly rich in lymphatic vessels. They begin in the mucous membrane between the bundles of connective tissue. In the muscular layer are found similar ves- sels, and they all communicate with a superficial network of vessels in the serous membrane. From the uterus the lymphatics go through the edges of the broad ligament. Those from tiie cervix form from two to four large trunks which follow the uterine artery and veins outward, and lie in the lower, and later in the outer edge of the Fig. 58. The lymphatics of the litems (Poirier) : 1, lymphatics from the body and fundus ; 2, ovary ; 3, vagina; 4, Fallopian tube : .">, lymphatics from the cervix; 6, trunks goiiifjr from the cervix to the iliac glands; 7, trunks going from tlie body and fundus to the lumbar glands; 8, anastomosis between cervical and corporeal lymphatics; 9, small lymjih- vessel In the round ligament, going to the inguinal glands; 10, 11, lymphatic vessels from the tube, which empty into the large vessels coming from the body of the uterus ; 12, ovarian ligament. broad ligament. They arc as wide as the uterine artery, and go to the iliac glands. Those from the body and fundus form two trunks on either side, which lie in the upjxn' border of the broad ligament, passing close to the hilum of the ovary. They follow the ovarian artery, going out to the pelvic wall and then turning upward to the lumbar glands, which lie in front of the lMinl)ar vertebne. On the anterior surface of the sacrum are the sacral glands, which (•onncct with the iliac and lumbar. The obturator gland at the inner opening of the obturator canal is rarely found and stands in no relation to 64 DISEASES OF WOMEN. the uterine lymphatics. Some lymphatics go from the uterus through the broad ligament to the inguinal glands. The lymphatics of the cervix and those of the body anastomose, both in the interior of the The nerves of the pelvic organs of woman (Frankenhiiuser) : 1, nerves to fundus of uterus; 2, right Fallopian tube; 3, right round ligament; 4, nerves to Fallopian tube; 5, com- munication between uterine and ovarian nerves ; 6. ovarian plexus of veins ; 7, ovarian vein ; 8, nerve passing to ovarian plexus ; 9, fimbriated extremity of Fallopian tube ; 10, reflected peritoneum ; 11, uterine nerves; 12, superior hypogastric plexus ; 13, branches from hypfigrastic plexus to uterus; 14. inferior hypogastric plexus; 15, vesical nerves; 16, communicating branches to vesical plexus; 17, cervical ganglion: ]<S, branches from hypogastric plexus to cervical ganglion; 19, first sacral nerve; 20, branches passing to bladder; 21, branches passing between bladder and rectum ; 22, communicating branches from second sacral to cervical ganglion ; 23, branch from third sacral nerve to cervical ganglion; 24, second sacral nerve : 25, branches from third sacral nerve to vagina and bladder ; 26, branches passing from fourth sacral to cervical ganglion. uterus and through a large vessel running in the broad ligament, along the edge of the uterus. The Nerves (Fig. 59). — Branches from the second, third, and ANATOMY. 65 fourth sacral (spinal) nerves meet with others from the hypogastric plexus (sympathetic) in a large ganglion on either side of the cervix, from which cervical ganglion branches go the uterus, the vagina, and the bladder. Those of the uterus end in the nucleus of the muscular cells, and in ganglia in the mucous membrane. Function. — The r6le the uterus plays as a copulative organ is not quite settled, but much evidence has been adduced in favor of the theory that it exerts a suction by which the semen is drawn into its cavity.' But it is a well-demonstrated fact that conception may take place independently of such action. The most important physiological destination of the womb is to furnish a place of attachment for the ovum, to shelter the fetus during its development, and to expel the child during parturition.^ The uterus is the seat of the chief portion of the menstrual flow. At the menstrual period its epithelium is thrown off, and a new one is formed in the interval between two menstruations. The Fallopian Tubes. The Fallopian tubes, or oviducts (Fig. 60), are two long, slender, round tubes connected with the upper angles of the uterus. Their Fig. 60. Posterior View of Left Uterine Appendages (Henle): 1, uterus; 2. Fallopian tube; 3, fimbri- ated extremity and opening of the Fallopian tube; 4, parovarium; 5, ovary; 0, broad ligament; 7, ovarian ligament; 8, infundibulo-pelvic ligament. length varies between 3 and 5 inches. Tlio tube starts from tlio ' Joseph R. Beck, Am. Jour. Ohnf., 1H74, vol. vii. p|). 353-391. 'Several oases are on record of women with a fracture of ttip spine, eausinf^ coin- (>lete paralysis of the aMoniinal muscles, in whom the child was expelled hv the mere contractions of the womb. 66 DISEASES OF WOMEN. highest point of tlie corner of the womb, above the round ligament in front and the ovarian ligament behind, whence it goes first out- ward, and then turns backward, lying near the wall of the pelvis, above and in front of the ovary, and finally it curves round the free end of the ovary, the abdominal end being turned against the ovary and the bottom of the pelvis. Sometimes it has even been found surrounding the ovary entirely, with the abdominal end resting on the ovarian ligament. It may be divided into three parts — the isthmus, the ampulla, and the fimbriae. The isthmus comprises about the inner third. It begins Fig. 61. Fallopian Tube laid open (from Playfair, source unknown) : ab, uterine portion of tube ; cd, folds of mucous membrane ; e, tubo-ovarian ligament, or fimbria ovariea ; /, ovary ; g, round ligament ; h, Graafian follicle. in the outermost and uppermost corner of the uterine cavity with an opening called the ostium uterinum, which is so fine that it barely admits a bristle. It goes through the wall of the uterus, and extends as a cord about ^ inch thick outward. The ampulla is the middle part, which is twice as thick or more, curved, and follows a serpentine course. It has also been called the receptaculum seminis, because it seems to be particularly destined to hold and preserve the spermato- zoids until they come in contact with the ovum. Its calibre admits a uterine sound. The fimbriae are the outermost part. They sur- round the outer end of the ampulla like a collar with long flaps. One of these, the fimbria ovariea, is attached to the free end of the ovary, and forms a channel. In the middle of the fimbriae is the ostium abdominale, which again is a very fine opening, leading into the peritoneal cavity. Often a pedunculated hydatid is found at the abdominal end. This was originally the end of the Miillerian duct, of which the tube is a development. As we have seen in the chapter on Development, the tubes have a common origin with the uterus. The point that forms the limit ANATOMY. 67 between the two is the insertion of the round ligament. The tube, like the uterus, is composed of three layers — a serous, a muscular, and a mucous — and each of these is continuous with the corresponding Fig. 62. Transverse section of the Fallopian tube (Ahlfeldt), showing the complicated arrangement of the longitudinal UAds (enlarged about twelve times). layer of the uterus. The serous coat is formed by the uppermost part of the broad ligament. That part of this ligament which is situated immediately below the tube, between it and the ovary, is called the mesosalpinx, or the a(a vcspertiUonh (bat's wing). The mesosalpinx is continued beyond the end of the tube as the so-called {iifundibulo- pelvic ligament, which goes from the fimbria? outward and backward to the iliac fossa, whence it carries the utero-ovarian vessels (internal sj)ermatic) to the tube and ovary. The nmscular coat consists of an outer longitudinal, an inner circu- lar layer, and near the uterus another longitudinal layer.^ It contains most of the blo(xl-vessels. The mucous membrane forms large and small longitudinal folds (Figs. 01, 63). It covers the inner side of tiie fimbriie, while the outer side is covered with peritoneum. It has a single layer of ciliated ' J. Whitridge Williams, Avi. Jour. Med. Sci, Oct., 1891, vol. cii. p. 378. 68 BTSEASES OF WOMEN. columnar epithelium, the cilia of which move in such a way as to push the ovum in the direction of the uterus. With increasing age the ciliated epithelium is, however, partially replaced by non-ciliated columnar and flat epithelium. The mucous membrane has no glands.* The muscular expansion from the outer layer of the uterus extends to the tube, and seems to be able to cause an erection of it. The uterine end moves with the uterus; the remainder is still more freely movable, since the tube is much longer than the straight line between its two ends, and its movements are only checked by the thin, loose, elastic mesosalpinx, the fimbria Ovarica, by which it is Fig. 63. Tube and Ovary of a Woman who died during menstruation, natural size (Farre) : I, broad ligament ; o, ovary ; rr, old corpora lutea ; /, isthmus of tube ; i, fimbriated end spread over ovary. connected with a movable ovary, and the infundibulo-pelvic liga- ment. The arteries of the Fallopian tubes come from the ovarian artery (Fig. 37). The veins go to the pampiniform plexus iu tlie broad ligament. The lymjyhatics unite with those of the ovary and go to the lumbar glands. The nerves come from the inferior hypogastric plexus of the sym- pathetic. Function. — The Fallopian tubes are the canals through which the ova pass from the ovaries to the uterus, and iu which probably, in most cases, impregnation takes place by the union of an ovum and one or more spermatozoids. It seems that during menstruation the fimbriae are spread out and applied with their mucous side to the ^ Otto Cohen, Med. Moiiatsschr., New York, Sept., 1890, vol. ii. p. 413. ANATOMY. 69 ovary, so as to catch the ovum when it leaves the Graafian follicle (Fig. 63). The surface of the ovary being four or five times larger than that of the fimbriae, it seems, however, impossible that these should always cover a bursting follicle. Many ova doubtless fall into the peritoneal cavity. The accompanying blood, if in small quantity, is absorbed. If copious, it forms periuterine hematocele. The ova perish or give rise to abdominal pregnancy. Some may also be sec- ondarily attracted to the Fallopian tubes by the current produced by the movement of the cilia of the latter. The Ovaries. The ovaries (Fig. 64) are two oval bodies situated in the true pelvis, to the sides of the uterus, below, behind, and to the inner side of the Fallopian tubes. They are about 1 J inches long, 1 inch wide, and I inch thick. They are, as it were, inserted in a hole in the posterior layer of the broad ligament, as a diamond is fastened to a ring. They are covered with a single layer of hexagonal columnar Ovary and Tube of a Nineteen-year-old Girl, seen from behind (Waldeyer) : U, uterus ; T, tube; LO, ovarian ligament (of uinisual length); o, ovary; x, limit of peritoneum. (The inner end of the ovary is too high.) epithelial cells,^ such as we find on mucous membranes, and entirely different from the large, flat endothelial cells covering the peritoneum. Their long axis is placed diagonally in the pelvis. They have an inner anterior end, an outer po-sterior end, an anterior outer edge, a posterior inner edge, an upper anterior outer surface, and a lower posterior inner surface.^ The inner end is fastened to the corner of ' As some authors deny tlie fact, first pointed ont by Waldeyer, that the ovary is not covered with peritoneum, I wish to state tliat I have satisfied myself hy numer- ous examinations of ovaries of women of the correctness of the above. * The reader will understand this mudi more readily if he takes an oblong box and gives the surfaces, ends, and edges tlie above indicated directions. 70 DISEASES OF WOMEN. the uterus, behind and below the tube, by means of the Ugammt of the ovary, a round cord, about an inch long, running at the upper edge of the broad ligament, between its two layers, and composed of connective tissue and unstriped muscle-fibres, which are a continu- ation of the outer layer of the uterine muscular tissue. This inner Fig. 65. Ovary and Tube of Girl twenty-four years old, seen from behind (Waldeyer): f7, uterus; T, tube ; LO, ovarian ligament ; o, ovary ; x, limit of peritoneum ; b, cicatrice after ruptured Graafian follicle. end of the ovary is tapering and thinner than the outer. The outer end is broader, fastened above to the fimbria ovarica and below to the infundibulo-pelvic ligament (Fig. 64). The anterior edge is nearly flat, and bound to the posterior layer of the broad ligament. The place where the vessels and nerves entei' is called the hilum. A white line marks the abrupt transition from the peritoneum to the ovarian epithelium, and this is situated on a higher level on the anterior surface than on the posterior. The anterior surface is less convex than the posterior. The posterior edge is strongly convex and free.^ The ovaries lie above the retro-ovarian shelves (which will be described later in speaking of the pelvic peritoneum), are sur- rounded with coils of the small intestine, and lie near the rectum. By introducing one or two fingers into the vagina as high up as pos- sible to the sides of and behind the uterus, and depressing the abdom- inal wall in the region of the iliac fossa, the ovaries can sometimes be felt. * By the data given above it is easy to distinguish the left from the right ovary, but the only way of obtaining a correct idea of the ovary is by remembering that it has a uterine end and a tubal end. an attached border and a free border, a smaller and a larger surface, for the organ is so movable that it is found in very different positions, so that expressions like upper and lower, inner and outer, are taken in the opposite sense by different authors. ANAT03IY. 71 In a young girl the surface of the ovary (Fig. 64) is even, smooth, velvety, of pearl-gray color. Later, each ovulation leaving a little puckered cicatrix, the sur- face becomes harder and shows irregular depressions (Fig. 65), and in old age it becomes nearly cartilaginous and loses part of its epi- thelium. As to its composition, the ovary may even macroscopically be divided into an outer part, called the parenchymatous zone, or coi'ti- FiG. 66. Section of the Ovary of a Cat, enlarged six times (Schron) : 1, outer covering and free border of the ovary (epithelium and albuginea) ; 1', attached border; 2, vascular zone, or medul- lary substance ; 3, parenchymatous zone, or cortical substance; 4, blood-vessels ; 5, Graafian follicles in their earliest stages, lying near the surface; 6, 7, 8, more advanced follicles, imbedded more deeply in the stroma; 9, an almost mature follicle, containing the ovum in its deepest part ; y, a follicle from which the ovum has accidentally escaped ; 10, corpus luteum. cal substance, and an inner, called the vascular zone, or medullary substance. The microscopical examination shows a greater number of layers. Under the columnar epithelium is found a narrow, somewhat harder layer called the albwjinca (Figs. 66 and 67). It is intimately con- nected with the subjacent parenchyma, from which it cannot be dis- sected off. Under the microscope three layers may be distinguished in it. It is composed of fibrous connective tissue with interspersed unstriped muscle-fibres. Under the ali)uginea is found a zone dis- tinguished by the presence of small follicles containing an ovum, the so-called ovisacs, or young Graafian follicles. Inside of this zone is foun<l another with much larger Graafian follicles. The tissne in which tiiese tbllicles are inii)e(l(led consists chieHy of unstri])ed mus- cle-fil>res and connective tissue, which are arrang('<l in circles around each follicle. The centre is formed by the so-caiUid vwdullari/ .sub- stance, or vascular zone. Here the connective tissue is much looser than in the parenchymatous zone, but it is full of uiistrij)e(l muscle- 72 DISEASES OF WOMEN. fibres, as well as the parenchymatous zone. The largest vessels are found most centrally and nearest the hilum. Nearer the surface and Fig. 67. Part of the Same Section as represented in Fig. 66, more highly enlarged (Schron) : 1. the epi- thelium and albuginea; 2, fibrous stroma; 3, 3', less fibrous, more superficial stroma; 4, blood-vessels ; 5, small Graafian follicles near the surface ; 6, one or two more deeply placed ; 7, one further developed, enclosed by a prolongation of the fibrous stroma ; 8, a follicle still further advanced; 8', another, which is irregularly compressed ; 9, part of the largest follicle; a, membrana granulosa; 6, discus proligerus; c, ovum; d, germinal vesicle; e, germinal spot. Fig. J layers Zone ofsmalll follicles Zone oflargi follicU Columnar' mlthdium Zone of ^ne vessels Loose connect- ii/e (issue ivtth large t^essels. ffilmn Diagram of Zones in Human Ovary. the free end they are smaller. A diagram (Fig. 68) may help to realize how these zones are distributed on a transverse section of a human ovary. The whole section appears pear-shaped, the zones ANATOMY. 73 being narrower near the* hilura and increasing in width toward the free border. The small follicles, measuring from 0.02 to 0.08 millimeter in diameter, are the same we have described in the history of the devel- opment (p. 26), but of the enormous number comparatively few are left. The large follicles constitute more properly what is called Graafian follicles, and can be seen with the naked eye as vesicles of the size of French peas. Fig. 69. Graafian Follicle of Adult Woman, 40 : 1 (De Sin6ty) : a, external layer, or tunica fibrosa; b, internal layer, or tunica propria ; c, blood-vessels ; d, membrana granulosa ; e, discus proligerus; I, liquor folliculi (coagulated); o, ovum. There are from six to twenty of these large follicles in an ovary. The ovisacs do not migrate. It is simply by their increased size that the larger follicles seem to form a zone inside of the small ones. In growing they push the surrounding tissue aside and extend deep into the interior of the ovary, and at the same time closer to its sur- face, until finally all tissue between the follicle and the surface is absorbed and the follicle can burst there. The wall of the Graafian follicle (Fig. 69) consists of two layei*s, an outer, denser, called tunica fibrosa, composed of fibres of connective tissue, and an inner, more delicate, softer, called tunica propria, and containing many cells and a fine network of capillary vessels. Al- though there is, microscopically, no line of demarkation between the follicles and the surrounding ti.ssue, they are easily pulled out. Inside of the tunica propria are found several layers of ej)ithelial cells, together called the memhraiia gramihsa. On one side these epithelial cells form a mass protruding into the cavity of the follicle, and called (Hmchh proligerus (Fig. 67, h). The outermost layer of cpitlielial cells of the Gnuitfian follicle has a regular columnar shaj)e ; tlie 74 DISEASES OF WOMEN. inner ones are more irregular and breaking down, except those immediately surrounding the ovum, which again form a regular single layer of columnar cells. The space between this epithelium and the discus proligerus is filled with a clear serous fluid called liquor folUculi, which contains a few cells, albumin, and paralbumin. It is formed by liquefaction of the cells of the membrana granulosa. Fig. 70. r**^ Mature Ovum of Rabbit, Hartnack f (Waldeyer) : a, cells from the discus proligerus (epi- thelium of ovum); 6, zona pellucida; c, vitellus; rf, germinal vesicle; e, germinal spot; /, large globules with dull lustre in the germinal vesicle. In the discus proligerus is imbedded the ovum (Fig. 70). The human ovum is 0.2-0.3 millimeters in diameter, or just about visible with the naked eye. The surrounding cells form a regular epithelial layer of short columnar cells all around it. Inside of that is found a fine membrane with radiating stripe, the zona pellucida, or vitelline membrane} The interior is filled with a semifluid mass called the vitellus. This is composed of larger clear bodies and minute dark ones, and one much larger vesicle called the germinal vesicle. The latter contains a little round body called the germinal spot. In the interior of the latter are found a few small dark granules, and some- times similar bodies are found in the germinal vesicle outside of the germinal spot. After the climacteric age the follicles and ova disappear, the whole organ shrinks, and its surface is very uneven. Corpus Luteum of 3Ienstr nation. — The Graafian follicle undergoes certain changes. As a rule, one attains during the intermenstrual ^ The vitelline membrane is something entirely different from the yolk-sac, although one name might seem to be a translation of the other. Fio. 74. Fkj. Fio. 71.— Ovary nf Woman two days after Menstruation fDalton), showing carlitst sta^e of a ruiitureil ami bloody (inuitlan follirlc into a corpus liitcuni. Fl<j. 72.— Ovary of Woman twenty days after Menstruation < Kalton). JJesides larvre fresli Been two smaller old on»-s. ami (iraafian follicles of ditl'crent size. Kio. 73.— Ovary of Woman nine days after Menstruation ilmlloin. Tlie dark s|iot Is the roundiUK yellow circle is the corj)U» luteum shining throutrli the traiisjiarenl tisstie. Fio. 74.— Ovary of Woman at Term of I'reKiianey iDaltoii), showing corpus luteum with tirm Vui. 75.— False Corpus Luteum (I)alton). transfo corpus ciciitri( white c rmalion of luteuiri arc •e ; the sur- entnil (•l(.t. ANATOMY. 75 period the size of a hazelnut (^ inch or more in diameter), the tissue between it and the surface becomes thinner and thinner, until, finally, it bursts and lets the ovum escape. The follicle is then filled with blood, which coagulates, forming a cherry-colored clot (Fig. 71). A few days later the wall begins to be enlarged and thickened, and this enlargement within a confined space causes it to become folded upon itself in short zigzag reduplications, mainly at the deeper part of the follicle (Fig. 72). These folds grow into the clot, and finally replace it. In this way is formed, during the intermenstrual period, a corpus luteum, occupying the substance of the ovary immediately beneath the superficial cicatrix which marks the site of the ruptured follicle (Fig. 73). Subsequently the whole structure diminishes in size, and becomes more and more intimately connected with the surrounding tissue, so that it can no longer be peeled out in toto. In a regularly menstruating woman it seklom liappens that we do not find three or more corpora lutea in different stages of growth or retrogression. The volume of the menstrual corpora lutea varies between about one- half and one cubic centimeter. By the eleventh week after menstrua- tion it is less than one-twentieth of a cubic centimeter. Corpus Luteum of Pregnancy. — If pregnancy takes place, no new corpora lutea are formed, but the one corresponding to the last men- struation becomes larger and stays longer. After the first month it continues to increase in size, or, at least, does not diminish, and its convoluted wall assumes the strong yellow hue which has given rise to its name. At the same time the central clot becomes fully decolor- ized, growing denser and firmer in proportion as it diminishes in bulk, until a firm white fibrinous clot is found iu the centre of the yellow ring (Fig. 74). Sometimes this clot has itself a central cavity filled witli a serous fluid. Beyond a certain period of pregnancy, the date of which is not precisely known, the corpus luteum diminishes in size, and loses the freslmess of its yellow hue. At the end of pregnancy it is reduced to about one-half of a cubic centimeter. There is up to this date great diversity of opinion among diiferent observers of equally high standing as to the origin of the corpus luteum. According to von Baer, it arises from the internal layer of the wall of the fTniaflian follicle, while, according to liischoff, it arises from the epithelium of the follicle — the membrana granulosa. Dr. J. G. Clark, who has used new methods of investigation, declares himself in favor of the first theory. He says that the lutein cells — those characteristic of the corpus luteum — are specialized connective-tissue cells, which appear in tlu; inner layers of the I'olli- cle-wall at the time when it begins to show a differentiation into two layers — the theca interna and externa. In tlu' mature follicle is found a fine reticulum stretching from the theca externa among the lutein cells, beyond whi(;h it is woven into a more or less fine 76 DISEASES OF WOMEN. line known as the membrana j)ropria — not to be confounded with the above-mentioned tunica propria, which is the same as the theca interna. At the time of the rupture of the follicle, this membrana propria is broken through in several places by the advancing lutein cells and blood-vessels, but quickly a connect- ive-tissue line reforms in front of the lutein cells, which ])ush it toward the centre, where it finally forms a dense core of inter- lacing fibres. The retrogression of the corpus luteum is characterized first by the fatty degeneration of the lutein cells, followed by the shrinking Fig. 76. Fig. 77. Fig. 76.— Ovary of Woman thirty-six years old (natural size) : a, albuglnea ; h, red zone ; c, rf, e. Graafian follicles situated in the red zone, which here broadens;/, all the remainder is taken up by yellow tissue indistinctly divided into several parts, probably corpora lutea of menstruation in retrograde metamorphosis. Fig. 77.— Ovary of Woman forty-seven years old (natural size): a, corpus luteum with cen- tral cavity ; 6, another corpus luteum ; c, a third small one ; besides this thirteen yellow bodies could be counted on the cut surface, and there were perhaps more in the" invis- ible p«rts of the ovary. Fig. 78.— Ovary of Woman twenty-nine years old : a, corpus luteum transformed into cyst; b, numerous yellow masses with remnant of central cavity ; cc, corpora nigra ; d, albu- ginea. of the connective-tissue net into a compact body (corpus jihrosum), after which it is gradually removed through hyaline changes until a very fine scar-tissue is left, which is at last lost in the ovarian stroma. Cessation of ovulation is induced through the densification of the ovarian stroma and a destruction of the peripheral circula- tion, which prevents the development of follicles.^ False Corpora Lutea. — Sometimes Graafian follicles degenerate. The wall becomes thick, opaque, whitish, and assumes a slightly car- tilaginous consistency. The fluid in the interior disappears, and the opposite surfaces come in contact M'ith each other. Tlie ovum dis- appears also. These follicles lie in the deeper parts of the ovary, and do not communicate with the surface (Fig. 75, colored plate, p. 76). ' J. G. Clark, "The Origin, Growth, and Fate of the Corpus Luteum of the Pig and Man," Johna Hopkins Hospital Eeport.% vol. vii, 1898. Several points in this article had already been elucidated by Dr. Mary Dixon Jones in the New York Med. Jour., May 10 and 17, 1890. ANATOMY. 77 They may be called false corpora lutea.^ When the corpus luteum has lost its yellow color and most of its vessels, and is chiefly com- posed of connective tissue, it is called corpus albicans. If such a body contains dark pigment, it is not white, but dark brown or black, and is called corpus nigrum or corpus nigricans.^ Quite frequently large or small extravasations of blood are found in the tissue of the ovary .^ The ovary has a rich supply of blood- and lymph-vessels, which enter at the hilum. The arteries (Fig. 37, colored plate, p. 45) come from the ovarian artery, follow a spiral course, and end in a fine cap- illary network in the tunica propria of the follicles. They have very thick walls and a small calibre. The veins follow the arteries, and go to the pampiniform plexus in the broad ligament. From that the blood is carried through tlie ovarian veins. The right opens into the inferior vena cava, and has a valve ; the left opens into the renal vein at right angles, and has no valve. The latter circumstance is per- haps the explanation of the much greater frequency of pain in the left side of the pelvis than the right in gynecological patients. The ovarian veins anastomose with the uterine (Fig. 57, p. 62). They are imbedded in the tissue in the same manner as those of the uterus. The lymphatics begin around the follicles, follow the veins, and go to the lumbar glands. The nerves come from the inferior hypogastric plexus (Fig. 30, colored plate, p. 39). Function. — The ovary produces and expels the ova by which the species is propagated. The expulsion is probably brought about by contraction of the unstriped muscle-fibres which form so large a portion of the organ, combined with congestion. The ovaries, like other glands, probably have an internal secretion that plays u great role in tiie general economy of the body. (See Results of Salpnigo- oupiiorectoniyj. The Parovarium. The parovarium (Fig. 79) is a remnant of the Wolffian body (see p. 22). It is situated in the connective tissue between the two layers ^ The term " false corpus luteum " is often, but less properly, used in the sense of corpus luteum of menstruation. '^ John C. Dalton, "Report on the Corpus Luteum," Am. Gyn. Trans., 1877, vol. ii. pp. 111-160. ^ In 1879-80, while investigating abdominal fluids, I made numerous sections of apparently normal human ovaries. In so doing I got the ini{)ression that there are many jirocesses going on in the ovaries which are not yet described. Other work has prevented me from following this track, Init it may be permissible here to jioint out the large numljer of yellow masses we find in seemingly normal ovaries of women. Fig. 7(5 is drawn in natural size from tlie ovary of a woman ihirty-six years olil, cut open lengthwise. I'nder tlie albuginea was found a red zone with three Gra-atian follicles, and the whole interior was taken up by yellow tis.-ue indis- tinctly divided into several jiartc. Fig. 77 is likewi.* drawn from nature, in the exact size. It represents the ovary 78 DISEASES OF WOMEN. of tlie broad ligaments, between the outer end of the ovary and the ampulla of the Fallopian tube. It can be seen by holding the broad ligament up against the light. It is a small, flat, triangular organ, the apex of which touches the attached edge of the orary. It is composed of from six to thirty spiral tubules. At the base these tubules open into one transverse tube, which may be followed as a solid cord in the direction of the uterus. This tube and cord correspond to Gartner's canal in certain animals (see p. 20), and are Fig. 79. Adult Ovary, Parovarium, and Fallopian Tube (Kobelt) : aa, parovarium ^or epophoron) ; 6, remains of the uppermost tubes of the Wolffian body ; c, middle set~ of tubes forming parovarium ; d, lower, atrophied tubes ; e, atrophied remains of Wolffian duct (Gartner's canal);/, the terminal bulb or hydatid of the Wolffian duct; ft, the Fallopian tube; i, hydatid of Morgagni ; I, ovary. a remnant of the Wolffian duct. The tubules have a wall com- posed of connective tissue, unstriped muscle-fibres, and a ciliated columnar epithelium. At the outer side there are some tubules which do not reach the ovary, and one of them, the end of the transverse tube, terminates often in a small cyst similar to the hydatid Morgagni (p. 30). At the inner side there are some tubules which have lost their lumen and become fine cords. The parovarium has no function, but is liable to become the seat of cystic degeneration. of a woman forty-seven years old. It shows a corpus luteum, a large yellow mass, and thirteen distinct small yellow masses. Examined under tlie microscope, these masses prove to be follicles with irregular lumps of yellow pigment interspersed in the thin tissue between the follicles, and sometimes in the follicles themselves. 1 am inclined to think that all this yellow pigment is a remnant of old corpora lutea. Fig. 78 is also drawn from nature, in actual size, and shows a corpus luteum transformed into a cyst, numerous yellow masses with remnant of a central cavity. and two corpora nigra. ANAT03IY. 79 The UiiiNARY Organs and the Rectum. The urethra, the bladder, the ureters, and the rectum are so closely connected with the genitals, and the gynecologist is so often called upon to treat diseases in these parts, that a brief rdsum^ of their anatomy would seem indispensable. Fig. 80. > i^f The Urethra. The urethra is a canal leading from the bladder to the vulva. It is from 1 to IJ inches long and ^ inch in diameter, but very dis- tensible. It is usually said to be straight or slightly S-shaped, but these descriptions are based upon post-mortem examinations. The fact that a catheter is best introduced by performing a curve round the lower end of the symphysis pubis, leads me to believe that it follows a curved course, with the concavity forward. It is imbedded in the vaginal wall. It is suspended to the pubic arch by the pubo-vesical ligament, and passes through the triangular ligament, between the layers of wliich it is surrounded by the compressor urethrse muscle, or Guthrie's muscle. An- other sphincter muscle surrounds the urethra and the vagina togctlier as a narrow belt just behind the vestibulo-vaginal bulbs. The urethra has an outer layer of circular unstrij)ed muscle-fibres, an inner longitudinal layer, and a mucous membrane. Tlie meatus urinarhis has already been de- scril)ed in speaking of the vulva (see p. 39). The mucous membrane, when not distend- ed, forms longitudinal folds. It has many dej)ressions and blind canals, so-called J/or- f/fff/ni's lacunce, and racemose glands (IJttrc's^ glands). Near the floor, just inside of the meatus, are found two canals, Skoie's r/Iands,^ or urethral ducts (Fig. HO), one on either side, probe of the French scale, and extend upward, ])arallel to the long axis of the urethra, from ^ to -} of an inch, in tlu^ nuiscular tissue, below the mucous membrane. The mouths of these tubules are ' This name is often erroneously spelt Littr(?, which is that of the author of a dictionary, just as (Jartner almost invariably is called (iiirtner, and Bartholin often Rartholini. Hoth were Danes. 'Skene, "The Anatomy and I*afholop;y of Two Important Glands of the Feninle T'rethni," Am. Jour. Obstet., 1880, vol. xiii. p. 205. Their glandular nature has been contested. The Urethra laid open from behind ; probes introduced into the urethral ducts (Skene). They admit a No. 1 80 DISEASES OF WOMEN. found upon the latter ^ of an inch from the meatus. If the mucous membrane is everted — which it often is in those who have borne children — the openings are exposed to view on either side of the entrance to the urethra. The upper end of these tubes terminates in a number of divisions which branch off into the muscular wall of the urethra. The mucous membrane of the urethra is of pink color, sur- rounded by a rich network of veins, and has a stratified flat epithelium. Vessels and nerves are derived from those of the vagina. Functions. — The function of the urethra is to serve as an outlet from the bladder. Its muscular tissue works probably as a sphinc- ter for the same. The Bladder. The bladder is a hollow muscular organ situated in the median line, between the pubic bones in front and the vagina and uterus behind. When empty, it is in the true pelvis ; when distended, it reaches more or less into the abdominal cavity, lying close against the abdominal wall. When empty, it has been found in two dif- ferent shapes — either so that the upper part falls against the lower, the cavity combined with the canal of the urethra having the shape of a Y, of which the two upper branches represent the bladder, and the lower trunk the urethra, or so that the anterior wall comes in contact with the posterior. In the latter case the combined lumen of the bladder and the urethra form a C or an L.^ The female bladder is shorter than the male in the antero-posterior direction, but more than makes uj) for this by being broader. I have myself drawn three quarts of urine from a woman who had no reten- tion of urine, and I have read that four litres have been evacuated from a female bladder. When distended it has an ovoid shape. We distinguish the base, the summit, the anterior and the posterior surfaces, and two sides. The base or fundus ^ is the lowest part of the organ. It is bound by rather dense connective tissue to the anterior wall of the vagina and the neck of the womb. Three 0])enings are found on it. In front is the internal opening of the urethra, wliich is flat, crescent-shaped. There is no funnel-shaped part here, so that the term " neck " is a misnomer. The urethra opens abruptly on the wall of the bladder. Behind there are two fine, lengthy slits ^ Hart and Barbour {Manual of Gynecology, 4th ed., p. 35) suggest ingeniously that the Y-shape is that of relaxation, and that the oval shape represents systole — i. e. contraction : but if the oval shape were due to muscular contraction, it could hardly be maintained after death. ' The reader will notice that in speaking of the bladder the word " fundus " is taken in an entirely different sense from that applied to the uterus. ANATOMY. 81 where the ureters open into the bladder. The triangle between these three openings is called the trigone (Fig. 81). Each of its sides measures about an inch. The base is formed by the intra- ureteric ligament. The distance from this to the cervix uteri varies. Fig. 81. Uterus, Ureters, and Upper Part of Varina of Woman forty years old, J natural size. All measurements were made in mtu with compasses, and then marked on the paper without regard to foreshortening : a, ureters ; b, uterus ; c, Fallopian tube ; d, ovary ; e, round liga- ment; i*', broad ligament; g, connective tissue; h, bladder (the antero-superior part re- moved to show attachment to cervix and vagina); t, vesical opening of ureters; j', inner aperture of urethra; k, urethra ; I, vagina ; m, incision and rent in the operation called gastro-elytrotomy as originally jKjrformed by I3audelo(;que. I have found it immediately under the os and half an inch below it. AV^hen the bladder is distended the distance increases to 1 inch. The surface on which the bladder is in contact with the vagina is heart-shaped. The boundary-line runs in the lower part parallel to and a little outside of the trigone. In the upper part it follows the outline of the vagina. The bladder extends | inch on the cervix. «2 DISEASES OF WOMEN. From tlie summit the uraclms, one of the false ligaments of the blad- der, goes to the umbilicus. The anterior surface lies against the body of the pubic bones and the anterior abdominal wall. It has no peri- toneal covering. The posterior wall is covered with peritoneum down to the level of the internal os, where it passes to the uterus. Fig. 82. Fig. 83. X 350. X 350. Fig. 82.— Superficial Layer of the Epithelium of the Bladder, front view, composed of poly- hedral cells of various sizes, witn one, two, or three nuclei (Klein and Noble Smith). Fig. 83.— Deep Layers of Epithelium of Bladder, side view, showing large club-shaped cells above and snialler, more spindle-shaped, cells below, each with an oval nucleus (Klein and Noble Smith). Under this fold lies some loose connective tissue. The sides are like- wise covered with peritoneum. The posterior wall is alternately in contact with the uterus or the small intestine, which latter likewise at times touches the sides. The wall varies in thickness, according to the degree of distension, between ^ and J inch. It is composed of a serous, a muscular, and a mucous coat. The serous coat is formed by the peritoneum. During pregnancy the connective tissue that binds it to the underlying tissue becomes so loose that during labor the blad- der becomes entirely stri])ped of its peritoneal coat. The muscular coat has an outer longitudinal and an inner circular layer of unstripetl fibres. When the bladder is much distended, the bundles can be seen to separate so as to present a kind of lattice-work. The muscular tissue is thicker around the o])ening to the urethra, which disposition prob- ably serves to press out the last drops of urine during micturition. The mucous membrane, examined with the galvanic cystoscope, has a bright pink color. In general it is loosely attached to the muscular layer, and forms folds when the bladder is empty. But at the trigone it is attached more solidly. It contains numerous lacuna3 and racemose glands. It is covered with transitional epithelium, in which several layers are discernil)le, an upper of flat and several deeper of large and small pear-shaped cells (Figs. 82, 83). The raucous membrane seems to be able to absorb substances injected into the bladder. Between the mucous membrane and the muscular coat there is, with the exception of the trigone, a well-developed submucous layer composed of connective tissue, elastic fibres, vessels, and nerves. ANATOMY. 83 Ligaments. — The bladder has four true aud five false ligaments. The ti-ue are thickened parts of the pelvic fascia. The anterior true ligaments are two in number, a narrow but strong band on each side, consisting to a great extent of involuntary muscle-fibers, and passing from the lower part of the pubis to the anterior surface of the blad- der, above the urethral opening. On the outer side of the anterior ligament the part of the fascia which descends to the side of the bladder is known as the lateral true ligament. The false vesical ligaments are folds of the peritoneum. There are two posterior, two lateral, and one sujierior. The posterior are the vesico-uterine ligaments (see p. 56); the lateral false ligaments extend from the iliac fossse to the sides of the bladder, each separated from the posterior ligament by the obliterated hypogastric artery. The superior false ligament (ligamentum snspensorium) is the portion of peritoneum between the ascending parts of the hypogastric arteries, and reaches from the summit of the bladder to the umbilicus. It covers the urachus, a fibrous cord which lies between the linea alba and the ligamentum snspensorium. The urachus is a remuant of the allantoid of fetal life, and has pre- served a long cavity, subdivided by partitions and lined with epithe- lium similar to that of the bladder. Sometimes this cavity commu- nicates with the bladder. Very rarely the whole bladder is found in the adult woman extending up to the umbilicus between the aponeuroses of the abdominal muscles and the peritoneum (see Hysterectomy). Vessels and Nerves. — The a/'^mcs come directly from the internal iliac {i\\Q superior, middle, and inferior vesical arteries) or from its branches, the sciatic, internal pudic, middle hemorrhoidal, and uterine arteries. The re/T^.s form large plexuses comnnniicating with those of tlie uterus, vagina, vulva, and rectum, and sending their blood to the internal iliac vein. The lympJiatics follow the veins and open into the in- ternal iliac glands. The nerves come from the hypogastric plexus of the sympathetic and the sacral nerves (cerel)ro-sj)inal). Function. — The bladder serves as a reservoir for the urine, which is intermittently thrown into it from the ureters. It is emptied by the contraction of its own muscle-fibers, while the sphincters are placed in the urethra. 84 DISEASES OF W03IEN. The Ureters.^ There are two ureters, long, slender cylindrical tubes, leading from the kidneys to the bladder. They are 16 to 18 inches long, and thick as a goose-quill in circumference. They are the continuation of the renal pelvis. They lie behind the peritoneum, imbedded in very loose connective tissue, and are much longer than the direct line bcr tween their two ends. At their upper ends the distance between them is 21 inches. From this point they go, with the exception of slight windings, parallel with each other, down to the spot where they cross the iliac vessels at the brim of the pelvis. In this part of their course they lie in front of the psoas muscle. They are crossed about midway by the ovarian vessels in front ; the right lies close to the outer side of the inferior vena cava, behind the ileum. The left lies behind the sigmoid flexure of the colon. They cross the lower end of the common iliac artery or the upper end of one of its two branches, the external and the internal iliac (Fig, 84), which lie behind them, and enter the pelvis. Here they describe a large curve. First they diverge, running downward, backward, and a little outward on the wall of the pelvis to a point near the spine of the ischium ; then they bend downward, forward, and considerably in- ward, so as to converge toward the bladder. They lie outside of the internal iliac artery, behind the broad ligaments, running down to their base, and then under them, and at the brim of the pelvis they lie behind the ovarian vessels where these turn inward through the infundibulo-pelvic ligament. They go right through the large plexus of veins found at the sides of the cervix uteri (Fig. 57, p. 62), behind the loop formed by the uterine artery (Fig. 56, p. 61). They cross the cervix at the distance of about ^ inch, from behind, at an acute angle, so as to come in front of and below it. On reaching the wall of the bladder they turn rather sharply inward, run for J inch in the wall, perforating it gradually, and open with a small longitudinal slit in the interior of the bladder. But their substance is continued from side to side as the interureteric ligament, a ridge that forms the base of the trigone. In crossing the cervix the ureters lie outside and above the anterior part of the side wall of the vagina on a spot as large as the tip of the finger. During pregnancy the course of the ureters undergoes a gi'eat change. Its middle part, that which in the unimpregnated condition ^ The knowledge of the topography of the ureter has acquired special importance in regard to the extirpation of the uterus. The questions involved have been inves- tigated by Polk and myself, separately and conjointly (Polk, N. Y. Med. Jour., May, 1892, vol. XXXV. pp. 451-53 ; Garrigues, on " Gastro-elytrotomy," New York, Apple- ton, 1878, pp. 67-74, also N. Y. Med. Jour., Nov., 1878) ; Garrigues, "Additional Remarks on Gastro-elytrotomy," Amer. Jour. Obstet., 1883, vol. xvi. pp. 45-49). ANATOMY. 85 sinks down to the spine of the ischium, is lifted up, together with the broad ligaments. From the point where the ureter crosses the iliac arteries it goes forward, downward, and outward, lying immediately under the peritoneum, on the wall of the false pelvis. A little behind Fig. 84. The Course of the Ureters, from a woman fifty-seven years of age, with atrophic uterus, J nat- ural size. Specimen drawn in situ. Ureters laid bare from the place where they cross the iliac vessels to the place where they pass under the broad ligaments. Bladder dis- sected from uterine neck and upper part of the vagina and drawn down in order to show the curve of the ureters and the trigone. The oroad ligaments have been removed and the bladder cut in the median line, so as to show the inside of it : a, ureter; b, com- mon iliac artery ; c, external iliac artery ; d, internal iliac artery ; e, uterus (appendages cut off ); /, bladder; g, site of vesical ap'erture of ureter on the inner surface of bladder (not visible) ; h, vesical aperture of urethra ; i, base of trigone (interureteric ligament) ; J, incision in bladder ; k, vagina. the end of the transverse diameter of the pelvis the ureter dips down into the true pelvis, and goes in a curved line inward, forward, and downward till it reaches the bladder. In this way it ])asses under the broad ligaments, and in front of the.se it lies again immediately under the peritoneum. From the point where it opens into the blad- der to the po.stcrior surface of the pubis behind the spine is a dis- tance of 3 inches. It will thus be seen that while the posterior ])art of the course of the ureter through the pelvis is lifted to so high a level, the anterior end retains its position. Structure. — The ureters have a fibrous coat, a muscular coat, M'ltii 86 DISEASES OF WOMEN. Fig. 85. an outer circular and an inner longitudinal layer, and a mucous membrane, with transitional epitliclium composed of an inner short layer, a middle columnar with long processes, and a deep layer of rounder and smaller cells (Fig. 85). The cells of the deeper layers very much resemble those in the deeper layers of the bladder epithelium. When not distended the mucous membrane forms longitudinal folds. It has no glands. Vessels and AWves. — The ureters re- ceive arteries from the renal, ovarian, internal iliac, and vesical arteries. The veins correspond to the arteries. The lymphatics lead to the lumbar glands. The nerves come from the sympathetic. Function. — The ureters lead the urine from the kidneys to the bladder. In cases of extroversion of the bladder or of large vesico-vaginal fistulse, it can be seen how the urine is spurted out wnth pretty regular intermissions. That the ureters may become much distended by accumulated urine may be concluded from the fact that if the bladder has been overfilled and is emptied, fresh de- sire for emptying it recurs soon, and gives issue to a disproportionately large amount of urine. The ureters are kept closed by the elastic tension in the mus- cle-fibres wiiich surround them, while they perforate the bladder, which tension is overcome when the pres- sure reaches a certain point. The Rectum. The rectum is the lowest division of the intestine, extending from the colon to the anus. Although the word " rectum " means straight, the intestine curves and bends so as to form three distinct parts. It enters the pelvis in front of the left illo-sacral articulation (Fig. 52, p. 56), goes first downward, backward, and inward, in front of the third or fourth sacral vertebra, to the median line ; here it turns forward and lies in con- tact with the cervix and the vagina (Fig. 49, ]). 54) ; finally, an inch from its end it turns rather sharply downward and backward at a right angle with the second part. This last part is called the anal canal (Figs. 33, p. 42, and 49, p. 54), and is the narrowest por- tion, while the part situated immediately above it is the widest, and Epithelium of Pelvis of Kidney of man X 350 (Kolhker): A, single cells ; iJ, the same, in situ ; a, small flat cells : 6, large flat cells ; c, simi- lar ones with bodies like nuclei in the interior ; d, cylindrical and cone-shaped cells from the deeper layers ; e, transitional forms. ANAT03IY. 87 is called the rectal ampulla. From here the gut tapers gradually to the upper end (Fig. 86). It is about 8 inches long, and when empty Fig. 86. Rectum inflated with Air (Chadwick) : D, D', anterior and posterior segments of the superior detrus(jr fsecium (so-called third sphincter) ; Ji, rectal ampulla ; t "ud *> the same points 80 marked in Fig. 8U. about 1| inches from c(\<2;q to cdt^c, but capable of such a distention that it sometimes nearly fills tlie pelvic cavity. Tlie way in which it collapses when empty depends probably on the condition of the vagina and the bladder. If those are empty, the rectum collajiscs from side to side (Fig. 34, p. 43), but if the other cavities arc dis- tended, it becomes compressed in an antero-})()stcrior direction. Structure. — The rectum is composed of" a ])eritoneal coat, a muscular coat, and a mucous membrane. In regard to its relation to the peri- toneum, it may be divided into three parts: the upj)er is completely covered, and has even sometimes a mcsorcctuia ; tlie middle is cov- ered with peritoneum in front only (Douglas's pouch); and tlic third 88 DISEASES OF WOMEN. has no peritoneal covering at all. The last part measures 1^ to 2 inches from the anal opening. The muscular coat has an outer longitudinal and an inner circular layer. Tlie longitudinal layer is spread all over, and does not form such bands as on the colon. Besides this, the mucous membrane con- FiG. 87. The Lower End of the Rectum in Vertical Section (Rvdvpier) : ], rectal mucous membrane; 2, line of separation between mucous membrane and skin of buttock ; 3, fat ; 4, levator ani muscle; 5, 6, external sphincter: 7, internal sphincter; 8, 9, longitudinal muscular fibers interlacing with those of sphincter; 10, filiform terminations of longitudinal fibers; 11, circular fibers ; 12, 13, longitudinal fibers of niuscularis mucosae. tains a layer of longitudinal fibers. At the lower end all the longi- tudinal fibers are intimately interlaced with certain other muscles that are attached to the rectum — the levator ani muscle, the external sphincter ani muscle, and the internal sphincter ani muscle — and can be followed down through them to the skin (Fig. 87). ANATOMY. The external sphincter ani muscle (Fig. 88, 13) is an elliptic layer of striped muscular fibres which surround the anal opening and lie directly under the skin. Behind it is attached by a tendon to the tip of the coccyx ; in front it blends with the transversus perinei Fig Muscles of the Perineum (Breisky): 1, glans clitoridis; 2, corpus clitoridis; 3, meatus urln- arius; 4, tendon of ischio-caveruosus muscle; 5, bulb; 0, ischio-cavcrnosus muscle; 7, vaginal entrance ; 8, sr)hincter vagina; or bulbo-cavernosus muscle ; 9, fossa navicularis; 10, Bartholin's gland; 11, superficial transversus perina-i muscle; 12, anus; 13, sphincter ani externus; M, 15, levator ani muscle; 10, coceygeus muscle; 17, great sacro-sciatic ligament; 18, obturator iuternus muscle ; 19, gluta.'us maximus ; 20, os coccygis. and sphincter vaginae muscles. It is the true vohmtary sphincter by which feces and gases are kept back. The internal sphincter ani muscle is only a thicker ])art of the cir- cular layer of the rectum situated inside of the external sphincter, and consi.sts of unstriped muscle-fibres, with a considerable admix- ture of striped fibres. It receives fibres from the deep layer of the 90 . DISEASES OF WOMEN. deep perineal fascia, from the superficial transversus perinei, and from the bulho-cavernosus muscles. It surrounds the anal canal, and is an inch hi(;h. It contracts and relaxes by reflex action, and is not subject to the -will. Tiie levator anl muscle (Figs, 88, 14, 15) forms an important part of the pelvic floor, and will be considered under that heading. The mucous membrane shows numerous folds. In the lower part of the rectum these have a longitudinal direction, and are called the colunms of Morgagni, and the depressions between them are called the sinuses of Morgagni. In the u}>per part transverse folds prepon- derate. Three of these (more rarely only two or one), situated within reach of the examining finger, are particularly developed, and called Houston^s valves. Commonly one of them is placed on the anterior wall, about 2 inches above the anus ; the others an inch higher up, on the posterior wall. They are semicircular, and, the transverse muscles extending from one to the other (Fig. 89), they form together a kind of circular valve, which ordinarily lies below the accumulated feces. This apparatus has been described as a third sphincter, but is, according to Chad wick, a detrusor ; that is, it serves to expel the feces.' The mucous membrane is covered with columnar epithelium and has many glandular pouches. The transition from the skin to the mucous membrane is distinctly marked by a so-called ivhite line. Melatipns. — The rectum lies in contact outside with the left ureter and left internal iliac artery. It has the left ovary in front, and rests on the pyriformis muscle and the sacral plexus. It is bound to the sacrum by the mesorectum in the upper part, and by fibrous connect- ive tissue and fat lower down. It lies in the gap left between the sacro-uterine ligaments. Loops of the small intestine lie between its upper part and the uterus, unless the latter be pushed far back by an overfilled bladder. In the narrow lower part of Douglas's pouch there are, as a rule, no intestines ; the rectum hugs the cervix and lies close up to the vagina. The anal canal forms the posterior wall of the perineal body, which separates it from the entrance to the vagina and the vulva. Vessels and Nei'ves. — The rectum has an abundant blood-supply. The arteries are the superior hemorrhoidcd from the inferior mesen- teric, the middle hemorrhoidal from the internal iliac or one of its branches, a branch of the middle sacral, and the inferior hemorrhoidal from the internal pudic. The veins form a rich plexus, and lead the blood tiiroutrh the inferior and middle hemorrhoidal to the internal iliac, and through the superior hemorrhoidal to the superior mes- enteric, a branch of the vena porta. The lymphatics go to the sacral ^ J. K. Chadwick, "The Functions of the Anal Sphincters, so-called, and the Act of Defecation," Tran-s. Am. Gyn. Soc, ii. pi>. 43-56. I have, however, frequently palpated these folds on patients, and do not find that it causes any expulsive eflbrt ANATOMY. 91 glands. The nerves come partly from the sympathetic nerve (the hypogastric plexus), partly from the cerebro-spiual system (sacral plexus). Function. — The rectum is a receptacle for the feces, and expels Fig. 89. RectiiTti cut open lonKitudinallv, find tlie mucous in(.nitjrane dissected off, so as to show the circular muscular fibres 'Ctiadwick) : J)jy, anteridr aud posterior segment of the superior detrusor (Veciuin (or third sphincter); .S", inferior detrusor fkcium (or internal spliincter); A, aims; + and * correspond to the same points in Fip. 8."). This drawing shows the mus- ctilar fibres passing from the anterior to the posterior segment of tlie superior detrusor, by the action of whicli they may be approximated to eacli other. them by the combined action of its circular and longitudinal fibers, the first contracting above and relaxing below the mass to be removed, and the latter preventing sacculation, straightening the canal, aiul pulling the relaxed part of the intestine up over the fecal mjLss. The internal s[)hiiu;ter can, by its contraction, push the nnicous membrane out through the anus, and thus bctjomes an expulsive muscle, as is very apparent in the horse. Tin; mucous membrane is ca|)able of 92 DISEASES OF WOMEN. absorbing, which explains many bad eifects of constipation, and is utilized for the administration of drugs and artificial alimentation. The Pelvic Peritoneum. The pelvic peritoneum is a continuation of the abdominal perito- neum, and covers the organs in the pelvis more or less completely. Fig. 90. Pelvic Peritoneum with Empty Bladder ; mesial section of frozen body, J (Fiirst). The dotted line indicates the peritoneum ; a, rectum ; b, vagina ; c, bladder ; d, uterus ; e, below pouch of Douglas ; /, symphysis pubis. It has been likened to a cloth which is being lifted up by pushing the organs from below u]) under it, by which they themselves acquire ANAT03IY. 93 a covering and certain folds and pouclies are formed. Thus the reader may imagine that the peritoneum is represented by a sheet of thin muslin, and that an apple representing the bladder, a pear represent- ing the uterus, and a banana representing the rectum are placed under it. Beginning in front, the peritoneum passes from the anterior abdominal wall at the upper end of the symphysis pubis to the top of the bladder (Fig. 90), covers its posterior wall down to the level of the internal os of the uterus, and its sides behind the obliterated hypogastric artery. When the bladder is much distended it rises into the abdominal cavity, and the peritoneum forms a pouch be- Diagram designed to show the antero-posterior outline of the pelvic peritoneum in the mesial pelvic plane, with distended bladder (Ranney): P/', peritoneum ; Ji, rectum; t/, uterus; B, bladder; S, symphysis pubis. The vesico-abdominal, the vesico-uterine, and Douglas's pouch are made very apparent. tween the abdominal wall and the bladder (the vcmcn-ahdomimd pouch), the deepest point of which lies an inch above the symphysis (Fig. 91). From the posterior surface of the bladder the pcvitoiieum ])n.<ses to tiie anterior wall of the uterus, covering it entirely above the cervix, and leaving a ])ouch between the two called the rrs-iro-iiferhie pouch. When the bladder is over-di.'^tended, the bottom of this ])ouch is raised a little, as represented in tiie figure Next, tlu^ peritoneum covers the whole posterior surface of the uterus, and 94 DISEASES OF WOMEN. generally it goes even an inch behind the posterior wall of the vagina, and thence it passes to the rectum, leaving a pouch between the two called Douglas's pouch, or the recto-uterine pouch. This pouch varies very much in depth, sometimes ending at the posterior utero-vaginal junction, and in other cases extending down as far as the entrance to the vagina. Tlic peritoneum covers the anterior surface of the middle portion of the rectum, surrounds the whole upper portion of the same, and passes to the sacrum as the meso-rectum. From the sides of the uterus the peritoneum passes to the wall of the pelvis, forming the broad ligaments, which cover the Fallopian tubes, the round ligaments, the ovarian ligaments, and the attached border of the ovaries. The uterus and the broad ligaments together form a partition which divides the pelvic cavity into an anterior inferior and a posterior superior part (Fig. 51, p. 55). The anterior compartment as a whole is called the utcro-abdominal pouch. In it we notice the utero- vesical ligaments and the round ligaments of the uterus. It is filled by the bladder, and, Avhen this is empty, by loops of the small intestine. Laterally, near the entrance to the obturator canal, it has been designated as the obturator pouch, or paravesical pouch (Fig. 52, p. 56). When the bladder is moderately filled, the loops of the small intestine are found in the upper part of the utero- vesical pouch. The posterior compartment may be subdivided into a central deep portion — i. e. Douglas's pouch — and two shallower lateral portions called para-uterine pouches. The bottom of this para-uterine pouch has been specially designated as the retro-ovarian shelf (Polk). The sacro-uterine ligaments form the boundary -line between these three portions. On tlie side walls of the para-uterine pouch the ureters are seen running under the peritoneum (Fig. 52, p. 56). The ovaries project into the lateral pouches, which also contain loops of the small intestine. Tliese are likewise found in the upper part of Douglas's pouch. In reference to the elevation of the peritoneum during pregnancy, see the description of the broad ligaments and the ureters (pp. 57 and 84). The para-uterine pouch is lifted up to the pelvic brim ; the para-vesical poucli is only lifted in its posterior part; and Douglas's pouch is not interfered with. The parts that have no peritoneal covering are the anterior wall of the bladder, the anterior surface and the sides of the cervix uteri, the whole lower part of the rectum, and the posterior portion of the middle part of the same. Function. — The function of the peritoneum is to allow free, smooth movement between the viscera. It presents a large surface, with great power of absorption. ANATOMY. 95 The Pelvic Connective Tissue. The dense connective tissue forming true ligaments or fasciae has already been considered, or will be considered in describing the pelvic floor. Here we have only in view the loose connective tissue, which is found everywhere underlying the peritoneum in larger or smaller quantity, and forms one continuous layer, which is a continuation of the corresponding layer of tiie adjacent parts. In some places it contains fat. Just above the symphysis pubis, behind the linea alba, is found a considerable layer of adipose tissue, the preperitoneal fat, which constitutes an important landmark in the performance of lapa- FiG. y2. Coronal Section of Pelvis, showing- tlie three cavities of the pelvis: the peritoneal, the sub- peritoneal, and the subcutaneous (I^usehlia). rotomy. It is continued behind the symphysis as rctro-puhh fat (Fig. 89), and lies here in front of the l)ladder. Between the base of the bladder and the vagina the connective tissue is rather tight. On the posterior surface; of the vagina tliere is a very loose layer. A large mass is found on both sides of the cervix uteri (Fig. 92), form- ing under the broad ligaments the parametria, which are united by a thinner portion in front and behind. On the body of the uterus there is only very little connective tissue without fat, but during pregnancy it becomes much looser and increases in bulk. The reetiun and the vagina are again imbedded iu considerable masses of fatty connective 96 DISEASES OF WOMEN. tissue. At the posterior fornix the distance between the vagina and the peritoneal cavity does not exceed one-third of an inch. From the uterus and the parametrium a thin layer extends between the two layers of the peritoneum which form the broad ligaments, and is here mixed with many elastic fibers and unstriped muscle-fibers. From here it is again continued up into the iliac fossae and the lumbar region, and forward and backward along the pelvic wall. The chief bulk of the subperitoneal connective tissue forms a fun- nel-shaped mass around the cervix and downward around the vagina to the insertion of the levator ani nmscle (see Figs. 92 and 97). Function. — The function of the connective tissue is to fill out all free spaces between the organs, to furnish a soft padding around organs of very changeable size, and to be the carrier of vessels and nerves. The Pelvic Floor. The pelvic cavity may be divided into three well-marked subdi- visions : the pelvi-peritoneal cavity, the subperitoneal space, and the subcutaneous space (Fig. 92).^ Of these we have already described the first and the second. The boundary-line between the second and the third is a muscular dia- phragm — the levator ani muscle — which is covered above and below with a fascia, and has openings for the passage of the urethra, the vagina, and the rectum. We shall now consider what remains to be studied under the three headings — the pelvic fascia, the pelvic diaphragm, and the perineal region. I. The pelvic fascia (Fig. 93) is a continuation of the iliac fascia. It is attached to the iliac part of the ilio-pectiueal line and to an oblique line on the posterior surface of the body of the pubic bone, extending from the upper and inner part of the obturator foramen to a point a little below the symphysis. At the upper end of the said foramen it leaves an opening free for the obturator canal. It descends on the inside of the bodies of the ilium and ischium, about halfway down the pelvic wall, where a strong sinewy cord, the so-called tendinous arch, extends from the spine of the ischium to the pubic bone just inside of the obturator canal (Fig. 94). This part of the pelvic fascia covers the obturator intern us muscle, and is also called the obturator fascia. It sends a thinner prolongation backward, covering the pyriformis muscle, and called the pyrifo7'mis fascia. At the tendinous arch the pelvic fascia is split into two layers, an upper layer called the vesico-rectal fascia, which bends inward over the levator ani muscle, and a lower layer, which continues to follow ^ The distinction was made by Luschka, but his names, cavum peritoneale, oavum subperitoneale, and cavum subcutaneum are bewildering, the two latter " cavities " being filled with solid tissue. ANATOMY. 97 the obturator internus muscle down to the inner edge of the ischio- pubic branches, and keeps the name of obturator fascia. Just below the insertion of the levator ani muscle this fascia gives off another investment of this muscle, called the anal fascia. Together with that part of the obturator fascia situated below the tendinous arch it forms the lining of the ischio-rectal fossa. Fig. 93. Fascia of Pelvic Floor (Savaprc): B, bladder: V, vapiiia ; /?, rectum; P. symphysis pubis; S, sacrum ; a. fascia covering psoas muscle; 6, obturator fascia; r, tendinous arch; d, reflection of fascia on to the rectum, vagina, and bladder; e. posterior portion of fascia covering sacral vessels and nerves; f, iliac fascia covering iliac vessels; (7, gluteal ves- sels ; h, sciatic vessels ; i, internal pudic vessels ; k, obturator vessels. From its insertion on the ])elvic wall the vcsico-roetal fa.scia goes inward and downward, covering the upper ,'^urfaco of the levator ani muscle, to the base of the bladder, the; vnginn, and the rectnni. In front, near the middle lino, a thicker, narrow ])art of this fascia forms the anterior true lujaracnh of (he Uaddcr, or the piiho-rc.sical lU/amcnfs (see p. 83). I^tween the two ligaments tlu; fascia is thin and depres.'^ed. Out- side of this ligament lies another, thicker band, the /dfcral tnie Ilf/n- merii of the bladder, which is attached to the side of the bladder. 98 DISEASES OF WOMEN. * From the under surface of the vesico-rectal fascia a prolongation fol- lows down with the vagina, surrounding it with a sheath that lies outside of the venous plexus and forms a strong ring around the vaginal entrance, where it coalesces with the deep perineal fascia. From the ischial spine a band goes to the side of the rectum, which is called tiie ligament of the rectum, and prevents too great lateral movement of the intestine. The fascia follows the rectum down as a sheath which gradually disappears near the anus. From the place Fio. 94. The Levator Ani : appearance when the pelvic outlet is looked at squarely. The cut ends projecting inward are those fibres which run into the recto-vaginal septum (Dickinson). where it strikes the rectum it is continued over on the pyriformis muscle as the pyriformis fascia. In some parts a double layer of fascia, with intervening loose con- nective tissue, serves to allow a sliding movement of one part on the other. Thus the fascia forms a pouch between the base of the blad- der and the neck of the womb, extending an inch lower down than the corresponding vesico-uterine ])ouch of the peritoneum. Between the vagina and the rectum a similar pouch is found which descends nearly to the vaginal entrance. In its totality the ])elvic fascia forms a very irregular fibrous layer under the peritoneal cavity and the underlying loose connective ti.ssue, the function of which is to strengthen the pelvic floor and give sup- port to the organs found in it, especially the bladder, the vagina, and the rectum. ANATOMY. 99 II. The Pelvic Diaphragm (Fig. 94). — Under the pelvic fascia, which forms a fibrous layer of the pelvic floor, is found a horseshoe- shaped muscular expansion, which is open in front, is attached all around to the wall of the pelvis, and forms a double loop behind the vagina and the rectum. It is generally described as two muscles, the levator ani and the coccygeus, but they touch each other with their edges, so that one is a continuation of the other, and sometimes they are even grown together. This diaphragm has also been de- scribed as composed of three muscles : the pubo-coccygeus, the obturato- coccygeus, and the ischio-coccygeus (Savage), but not one of the fibers that start from the pul)es is inserted on tlie coccyx. The levator ani muscle takes its origin from an oblique line on the posterior surface of the body of the pubic bone, running from the upper end of the obturator foramen to the lower end of the symphysis pubis, just above and inside of the insertion of the obturator internus muscle {M. pubo-coccygem). It starts half an inch from the middle line of the symphysis. Its other bony origin is a small circle just in front of the base of the ischial spine. Between these two points it springs from the tendinous arch of the pelvic fascia (71/. obturato- coccygeus). The pubic portion (31. pubo-coccygeus) goes backward and inward, is in connection with the deep layer of the triangular ligament, and is attached to the urethra. It crosses the vagina, and is united to it by strong connective-tissue attachments, besides that the longitudinal fibers of the vagina on its lateral aspects are interwoven with those of the levator. Some loops go from side to side between the vagina and the rectum, but the greater part go behind the rectum, forming loops without intermediate tendon. They hug the concavity of the end-curve of the rectum and sujiport it from below (Fig. 95). The muscle goes in between the external and internal sjihincter, and in- termingles with both of them, as well as with the longitudinal fibers of the rectum. Some of the fibers are inserted on the thin mesial aponeurosis, extending from the coccyx to the anus {raphe ano-coccygea). The fascial ])ortion of the levator ani muscle (M. obfurato-coc- cygeiui) goes with convergent fibers to the rectum and the coccyx. It takes part with the pubi(^ portion in the formation of a looj) behind the rectum, and another i)art of it is inserted on the fourth coccygeal vertebra. The ischio-coccygeal muscle (= the cocof/geus) forms likewise a tri- angle, but the base of this triangle is turned inward. It takes its origin on the spine of the ischium and the lesser sacro-sciatic liga- ment, and is inserted on the side of the upper part of the coccyx and the last two vertebrie of the sacrum. Function. — The jxjlvic diaphragm strengthens the pelvic floor; in 100 DISEASES OF WOMEN. connection with the two fasciae that cover its upper and lower surface (the vesico-rectal and the anal fasciae) it forms a strong sup])ort for the uterus and the bladder. It is the antagonist of the thoracic diapliragni, being relaxed under inspiration and contracting under expiration. By inserting a Sims's speculum it is easy to see the Fig. 95. Anus Side View of the Levator Ani (L) after Removal of the Ischium. The lower bundles are the strong and heavy ones. The sphincter ani is shown surrounding the anus, and the coccygeus (C) is faintly indicated (Luschka-Dickinson) : rhythmical movement synchronous with respiration. The anterior wall of the vagina goes downward and backward during inspiration, and upward and forward during expiration. The pelvic diaphragm lifts the rectum up during the act of defeca- ANATOMY. 101 tion, and draws the anus forward in the direction of the symphysis. It exercises a similar function toward the vagina during childbirth by pulling it upward and pushing the child forward, so as to make it turn round the pubic arch. By means of the loops that go between the vagina and the rectum it becomes a sphincter vagina^, which can produce coarctation of the vaginal entrance. It draws the coccyx forward. III. The Perineal Region. — The perineal region is a somewhat rhomboid space bounded by the symphysis and on either side by the descending ramus of the pubic bone, the ascending ranuis and the tuberosity of the ischium, the lower edge of the gluteus maximus muscle, and the tip of the coccyx. In depth it comprises all the Fig. 96. Diagram of the Fascia of the Pelvic Floor in mesial section, to show how tiie levator anl muscle is backed by strong and dense sheets of fibrous tissue (Dickinson): 1, superficial perineal fascia, outer layer (this we call simplv subcutaneo\is adipose tissue) : '2, super- ficial perineal fascia, inner layer (our superficial perineal fascia); '.i, triauKular liKanient, or deep perineal fascia, outer layer: 4, triangular ligament, or deep perineal fa.scia, inner layer; 5, vesico-rectal (part of pelvic) fascia. ti.ssue lying within these boundary-lines between the surface and the pelvic diaphragm. It is shorter and broader than in man, and con- tains more fat. It may be subdivided by a line drawn just in front of the tuberosity of the ischium on either side into two triangle.^, an anterior or uro-cjenital region, and a posterior, or (imd region. 102 DISEASES OF WOMEN. In the anterior triangle we distinguish the following layers : Skin ; Adipose tissue ; Superficial perineal fascia ; Deep perineal fascia divided into two layers ; Anterior continuation of ischio-rectal fossa ; Levator ani muscle ; Vesico-rectal fascia (i. e. part of pelvic fascia). ' In the posterior triangle are found the following layers : Skin ; Adipose tissue entering and filling ischio-rectal fossa ; Anal fascia inside, lower part of obturator fascia outside ; Levator ani muscle inside, obturator muscle outside ; Vesico-rectal fascia. A. The Perineal Fascia and Ligaments. — The uro-genital region has under the skin a layer of adipose tissue (Fig. 96), which is a continuation of the similar layer on the surrounding parts (Fig. 97). Under that layer is found a sheet of dense connective tissue called the superficial perineal fascia. It is attached in front and on the sides to the edge of the rami of the pubis and ischium, and behind it turns over the superficial trans- versus perinsei muscle, and is here grown together with the deep peri- neal fascia. In its anterior part it is grown together with Broca's pouch (p. 37), and at the ramus of the ischium with the obturator fascia. The deep perineal fascia, also called the triangidar ligament of the urethra, has two layers — an anterior, or superficial layer, and a posterior, or deep layer. The su- perficial layer is at the sides at- tached to the rami of the pubes and ischium, in front to a strong transverse ligament called the transverse ligament of the pekis (Henle), which lies immediately under and behind the subpubic ligament, an opening for the dorsal vein of the clitoris separating the two. Behind it is grown together 2PM4 Transverse Section of Pelvis through Axis of Vagina (Savage) : V, vagina, showing posterior wall; O, ischio-rectal fossa filled, ■with fat; I, ischial tuberosity; B, perito- neal cavity; D, recto- vesical fascia cover- ing ujiper surface of levator ani muscle ; C, anal fascia covering lower surface of levator ani; N, obturator fascia; P, pos- terior aponeurosis of perineal septum, or the deep layer of the triangular ligament; M, anterior aponeurosis of the same, or superficial layer of the triangular liga- ment; S, superficial perineal fascia; 1, cross-section of right crus clitoridis and erector clitoridis muscle ; 2, superficial transvers\is perina'i muscle ; 3, bulb ; 4, deep perineal muscles. ANATOMY. 103 with the superficial perineal fascia and with the deep layer of the deep fascia. The deep layer of the deep fascia is likewise fastened to the rami of the pubes and the ischium, where it joins the obturator fascia (p. 96), and covers the anterior part of the lower surface of the levator ani muscle. At its anterior attachment it is contiguous with the vesico-rectal fascia. Behind it is continued as a dense fascial sheet covering the lower surface of the levator ani muscle (the anal fascia, or levator fascia). The deep perineal fascia is perforated by the urethra and the vagina. Where the superficial perineal fascia and the two layers of the deep perineal fascia come together, at the posterior margin of the super- ficial transversus perinaei muscle, they are fortified by a strong trans- verse fibrous baud, the ischio-perineal ligament, which is inserted on the ramus of the ischium, just in front of the tuberosity, and forms the boundary-line between the uro-genital and the anal regions. It is a strong cross-beam, which by its connection with all the adjacent parts, forms the chief support of the pelvic floor. Together with the pos- terior end of the superficial and deep perineal fascise it forms a parti- tion between the anterior and posterior part of the perineal region, called the transverse perineal septum. In the anal region the skin is darker and has large sebaceous glands. The anus forms an opening at the deepest point of the sulcus between the nates. It is closed from side to side so as to show a line of closure in the antero-posterior direction (Fig. 88, 12). It is surrounded by radiating folds of tiie skin, and often hairs. In women the raphe between the anus and the vulva {perineal raphe) is often effaced, and has sometimes a whitish color, much like a cicatrix, which has to be borne in mind in answering the question whether a subject for examination has given birth to a child or not. Under the skin is found a thick layer of adipose tissue. There is no special superficial fascia, and the deep perineal fascia does not extend so far back. Between tiie rectum and the ischium is found a space on either side which is called the isohio-recial fossa, and has the shape of an irregular triangular pyramid. Its top is at the spine of the iscliium ; the inner wall is formed by the levator ani muscle, covered by the anal fascia, the outer by the obturator intcrnus muscle, covered by the obturator fascia, below the line of dcniarkation between that fascia and the vesico-rectal fascia covering the upper surface of the levator ani muscle (p. 90). Its entrance from below is bounded by the lower edge of the gluteus maximus and the greater sacro-sciatic liga- ment behind, the transversus j)erinaei superficialis muscle in front, and the external sphincter ani on the inner side. Posteriorly thes(> two spaces communicate by means of the loose adipose tissue behind tlu; rectum and pelvic fascia. In front the fossa is limited by the line of junction of the superficial and deep perineal fasciic. I Fere it be- 104 DISEASES OF WOMEN. comes narrow, but may be followed above the deep fascia of the perineum along the origin of the levator ani muscle. It appeal's triangular both on perpendicular and horizontal section (Fig's. 92 and 97). . . The above-mentioned fasciae constitute a frame-work in which lie imbedded muscles, blood-vessels, nerves, and other organs. B. Penneal Muscles. — In the uro-genital triangle we find a super- ficial layer of three pairs of muscles (Fig. 88, p. 89) situated between the Perineal Muscles (Henle) : CL, clitoris turned over to the left side ; CCC, corpus cavernosum clitoridis : CCU, corpus cavernosum urethra, or vestibulo-vaginal bulb; CVA, anterior column of vagina ; CW, vulvo-vaginal gland ; BC, 1, 2, 3, bulbo-cavernosus muscle ; JC, 1, i, ischio-cavernosus muscle : TPS, transversus perinsei superflcialis ; TPP, transversus peri- nsei profundus muscle; S, 1, 2 ,3, sphincter ani externus; XX, layer of smooth muscle- fibers between vagina and rectum; +, limit of pubes and ischium. superficial perineal fascia and the anterior layer of the deep perineal fascia — namely, the ischio-cavernosus, or erector clitoridis muscle ; the hulho-cavernosus, or sphincter vagince muscle; and the superficial transversus pei'inoei muscle. The vichio-cavernosus muscle is a long, slender muscle which arises by two slips on the inside of the tuberosity of the ischium and the ascending ramus of the same (Fig. 98). It covers the corpus cav- ernosum of the clitoris, and is inserted with a tendinous expansion on the free part of the clitoris. Its function in the female is insig- nificant compared with that in the other sex. The bulbo-cavernosus muscle receives some fibers from tlie external sphincter ani and levator ani and the superficial transversus perinsei ANATOMY. 105 muscles, and others originate on the ischio-perineal ligament and neighboring tendinous tissue. The posterior ends are united by organic muscular fibers. It goes forward, outside of the vulvo-vagi- nal bulb, and splits up into three tendons, one inserted on the poste- rior aspect of the bulb, another on the mucous membrane between the clitoris and the urethra, and the third on the lower surface of the clitoris. It compresses the bulb, and thus aids in the erection of the clitoris. It may squeeze out the secretion accumulated in Bartholin's gland. It divides the role of a sphincter with the constrictor vaginae, and, above all, the levator ani muscle. The superjicial transversus pemnoei muscle originates from the inside of the tuberosity of the ischium, behind the ischio-cavernosus muscle, goes across the perineal region, and is inserted in the transverse sep- tum of the })erineum in the angle between the bulbo-cavernosus and the sphincter ani externus, intermingling with both. In many women its course is more forward, so that it does not reach the perineal body, but is fastened to the outer edge of the bulbo-cavernosus muscle. When it has its normal insertion it helps to steady the perineal body and push the presenting part of the child forward toward the pubic arch during parturition. With its abnormal insertion it can only help to open the vaginal entrance. In the anal region we find immediately under the skin surround- ing the anus the external sphincter ani muscle (p. 89). Under the tendon of the sphincter ani muscle, between it and the levator ani muscle, in front of the tip of the coccyx, lies the so-called coccygeal gland, a small body of the size of a pea, wiiicli seems to be a remnant of a more developed middle sacral artery, such as it is in animals with a tail.' It consists of round or tubuliform vesicles formed by a structureless membrane, inside of which are found cells. The whole is surrounded by a capsule of connective tissue, and re- ceives numerous branches from the middle sacral artery and the sym- pathetic nerve, especially the coccygeal ganglion. The deep muscles in the uro-genital region are not well develoj^ed or clearly soparaterl from one another. They are, therefore, enu- merated and described ditterently by different anatomists. Most commonly the following three are recognized : the constrictor urethra', the de^'p transversius ]>erin<ri, and the constrictor vagince muscles.^ They are all situated between the two layei-s of the deep perineal fascia. The constrictor urct}ir(v, or compressor urctJira', or Guthrie's muscle, ' An interesting article on tliis subject, illiistnited witli fipures, was piil)lislu(l liy Anpustus ('. IJernays of St. Louis in the u^fcdirnl liriij, Nov., ISST, vol. xv. j). ll'.i. '■'Some descrilte a dfjireKmr nrethnr (or J(irj(ir(ii/'!< muscle), a transver.H' muscle join- ing the constrictor from helf)w and going from side to side over tlu' urethra, ;uiil ;i tnuii'irrsm nrrlhrn- mimrli; coming from a})ove and inserted on the upjjer surface of the same. Tliev are probably only parts of tiie onMriclor urcthnr. 106 DISEASES OF WOMEN. consists of transverse fibers arising from the ischio-pubic rami and both layers of the deep perineal fascia, and crossing from side to side above and below the urethra, for which thev form an upper sphincter (p. 79). The deep transversus perincei muscle arises from the ramus of the ischium just behind the constrictor urethrae, and goes horizontally to the side of the vagina. By some it is merely regarded as the poste- rior fibers of the constrictor. It helps to steady the vagina. The consi7'ictor vagince muscle consists of a few fibers which arise from the transverse septum of the perineum, and encircle the vaginal entrance as a sphincter. Thus the deep transversus and the con- strictor vaginae correspond to the superficial transversus and the bulbo-caveruosus of the superficial layer. In the anal region we have the internal sphincter ani (p. 89) and the levator ani, inclusive of the ischio-coccygeus (p. 99). The ante- rior part of tiie levator ani lies immediately on the deep layer of the deep perineal fascia. C The Perineal Body. — The name of perineal body has been given to the tissue comprised between the rectum and the genital canal, below the point where the former turns backward (p. 86). Much diversity obtains among authors about its shape — a divergence of opinion easily accounted for when we notice how different its shape appears on sagittal section (Figs. 34, 49, 89). Sometimes the whole space between the rectum and the vagina up to the cervix uteri forms one triangular surface. In other cases this space is easily distinguish- able into an upper narrow and a lower broad part, the latter alone deserving the name of perineal body ; but this body, again, appears with very different forms, and differs in extension upward. Some- times the wliole body lies below the hymen ; in other cases it extends more or less up behind the vagina. The shape is sometimes nearly quadrangular, with one surface to the skin, one to the rectum, one to the vulva, and one to the vagina. In others it has the shape of the quadrant of a circle ; in others, again, that of the receiver of a retort, the neck of Avhich is formed by the narrow part between the vagina and the rectum. When we take into consideration that all the parts concerned consist of more or less soft tissue, this great diversity of form is easily understood. The perineal body (Fig. 99) is composed of the posterior ends of the bulbo-cavernosi muscles, the organic muscular fibers uniting them behind, fibers belonging to the superficial transversus perinsei, the external and internal sphincter ani, and the levator ani muscles, the ischio-perineal ligament, the posterior part of the superficial and deep perineal fasciae, the anal fascia, and adipose tissue. It is covered below by the skin lying between the anus and the rima pudendi ; behind by the rectal mucous membrane ; above and in front by the ANATOMY. 107 mucous membrane of the vulva and sometimes by that of the vagina. It has no definite Jateral limits, imless we arbitrarily suppose it con- Fia. 99. ^EAI NAVICULWy 'levatcrrfttscia- Jfiansular Ugmtt JuperficiiUlayer. •Sup-Penneal faida. Sagittal Section of the Perineal Body, showing its component structures (life size; Dicliinson). tinued to the tuberosity of the ischium. The cutaneous surface is shorter than in man. It measures J to 1 inch in length, while the distance from the anus to the entrance of the vagina (p. 43), the true length of the perineal body, is about If inches. According to what has just been said about its upper limit, no definite height can be ascribed to it. Small as this body is, it is of great importance by forming the cen- tre of the whole perineal region, where muscles, fascioe, and ligaments come together. They being fastened to the surrounding bones, the perineal body becomes tlie chief support of the whole pelvic floor. Especially it keeps the vagina and the rectum in their proper relative position. During childbirth it forms a strong barrier against which the child is being pressed from above and pushed by passive and active counter-pressure forward around the pubic arch. D. The Projeciion of the Pelcio Floor. — The perineal region forms a curve in the antero-posterior direction. The most projecting por- tion is that immediately surrounding the anus. The average dis- tance from this point to a straight line drawn from the tip of the coccyx to the top of the piil)ic arch {i. e. the antero-posterior diame- ter of the outlet of the i)elvis) is 1 inch.^ E. The Arteries of the Perineal Region are the infernal pudic and branches thereof, and the superficial and deep external pudic. The internal pudic artery, a branch of the internal iliac, is much smaller than in the male. It passes downward and outward, emerges from the pelvis through the greater ischiadic foramen, between the pyri- * Foster, Amer. Jour. Obstct., 1880, vol. xiii. pp. 35, 30. 108 DISEASES OF WOMEN. formis and ischio-coccygeus muscles, goes behind the spine of the ischium, re-enters the pelvis through the lesser ischiadic foramen, goes inside of the ischium, H inches above the lower end of the tuberosity, where it lies on the obturator internus muscle in a sheath formed by the obturator fascia and the falciform ligament, a prolongation of the greater sacro-sciatic ligament. It reaches the margin of the ascending branch of the ischium, perforates the deep layer of the deep perineal fascia, continues its course along the margin of the descending branch of the pubis, perforates the superficial layer of the same fascia, and finally divides into its two termmal branches, the dorsal artery of the clitoris and the artery of the corpus cavernosum. Before that it gives off four branches to the perineum — the inferior hemorrhoidal, the superficial perineal, the transverse peri^ieal, and the artery of the hxdb (Figs. 100 and 101). Fig. 100. Superficial Structures of the Female Perineum (Weisse) : a. external superficial perineal nerve; b, internal superficial perineal nerve; c, superficial perineal artery; d, inferior pudendal nerve; e, pudic nerve; /, internal pudic artery; (j, inferior hemorrhoidal artery ; h, inferior hemorrhoidal nerve ; i, tendinous center of perineum ; j, coccyx. The inferior hemorrhoidal consists of two or three branches which start on the inside of the tuberosity, cross the ischio-rectal fossa, and ANATOMY. 109 end between the skin and external sphincter aui, giving branches to them and the levator aui. Fig. 101. Dissection of Female Perineum ; on the ri^ht side the perineal muscles are exposed by the reflection of the perineal fascia; on the left side the muscles and the superficial layer of the triangular litrameiit have been removed, thereby exposing the deep layer of the ligament (modified from Weisse): a, dorsal vein of clitoris; ft, dorsal artery of clitoris; c, inferior pudendal nerve; d, artery of bulb; c, ])udic nerve ;/, internal i)Udic artery ; g, inferior hemorrhoidal artery; /;, inferior hemorrhoidal nerve; i, tendinims perineal center; J, superticial transversus perinrei muscle; k, ischio-cavernosus muscle; S\', sphincter vagintt; l', vagina; .5.1, sphincter ani. The superficial perineal artery is a longer branch. It originates a little in front of the former, runs parallel to the ischio-pubic branches, either above or below the transversus periuici muscle, between the superficial and the deep perineal fascia, and between tlie ischio-cav- ernosus and bulbo-cavernosus muscles. It then passes through the superficial perineal fascia, in wliich respect it differs from tiie corre- sponding artery in the male. It sends branches to tlie named muscles and ends in the vulva. The t7'an8verse perineal artery ])erforates the deep layer of the deep perineal fascia, follows the superficial transverse jierincal muscle, and 8Uj)plies this nuiscle, the vestibulo- vaginal bulb, and JJartholiiTs gland. The artery of tlie bulb is smaller than in the opposite sex. It conu's 110 DISEASES OF WOMEN. from the internal pudic between the two layers of the deep perineal fascia, and pierces the superficial layer of the same. It supplies the vestibulo-vaginal bulb and the meatus urinarius. The artery of the corpus cavernosum and the dorsal artery of the ditoins are much smaller than in the male, and that of the corpus cav- ernosum is again the smaller of the two, while in the other sex the opposite is the case. The artery of the corpus cavernosum is dis- tributed in the crus. The dorsal artery of the clitoris follows the upper surface of the clitoris, and ends in the glans and prepuce. The supa'Jicial extamal pudic artei-y is a branch of the femoral, passes through the saphenous opening, and spreads on the labia majora. The deep external pudic artery comes likewise from the femoral. It crosses the pectineus muscle, pierces the fascia lata at the inner side of the thigh, and goes to the labia majora, where it anastomoses with the superficial perineal artery. Hemorrhage. — In the median line of the perineal region there is no artery of any importance. The nearer an incision is made to the tuberosity of the ischium and the ischio-pubic branches, the greater is the danger of hemorrhage. The internal pudic artery is the only one that requires ligature on both ends (Ranney). F. The Veins of the Perineal Region lead to the internal pudic and the internal saphenous veins. From the hemorrhoidal plexus (p. 90) the inferior heraorrhoidal vein follows the homonymous artery to the internal pudic vein. In the uro-genital region the veins do not cor- respond with the arteries. There is a single dorsal vein of the clit- oris, beginning with small twigs from the glans and prepuce, running backward in the median line between the two dorsal arteries. It goes through an opening between the infrapubic ligament and the transverse ligament of the pelvis (p. 102), and divides into two branches that open into the pudic plexus, which surrounds the upper part of the urethra. To this plexus go likewise the veiiis of the corpus cavernosum — i. e. several short, thick trunks which originate in the interior of the corpus cavernosum and form one branch on either side — and several veins of the bulb. The pudic plexus anasto- moses with the vesical and vaginal plexuses (pp. 83 and 45) and the obturator vein. From this plexus two internal pudic veins on either side follow the corresponding artery through the sheath of the obtu- rator fascia and open into the internal iliac vein. The external pudic veins follow the corresponding arteries, and open into the internal saphenous vein. G. The lymphatics of the perineal region lead to the inguinal glands. H. The Nerves of the Perineal Region. — The perineal region re- ceives its nerve-supply from the pudic nerve and from the inferior pudendal branch of the small sciatic nerve. ANATOMY. Ill The pudic nerve comes from the sacral plexus, follows the internal pudic artery out through the great sacro-sciatic foramen, behind the spine of the ischium, and in through the lesser sacro-sciatic foramen. Its branches are the infetnor hemorrhoidal, the perineal, and the dorsal nerve of the clitoris. . The inferior hefniori'lioidal nerve crosses the ischio-rectal fossa, lies between the skin and the superficial perineal fascia, and gives branches to the external sphincter ani. and the skin around tiie anus. Its ante- rior branches combine with those of the superficial perineal and inferior pudendal nerves. The perineal nerve is the chief branch. It lies inside of the ischium, below the internal pudic vessels, in the same sheath of the obturator fascia. It breaks up into superficial and deep branches. The superficial perineal nerves are two in number — an external or posterior and an internal or anterior. They run forward between the superficial and the deep perineal fascia, perforate the superficial fascia so as to come to lie between it and the skin, one on either side of the superficial perineal artery, and end in the labia majora. They give branches to the skin, and connect with branches from the inferior hemorrhoidal and the inferior pudendal nerves. The deep perineal nerves generally arise by a single trunk, and are distributed to nearly all tlie muscles of the perineal region — the sphincter ani externus, levator ani, transversus, bulbo-cavernosus, and ischio-cavernosus — and to the vestibulo-vaginal bulb. The dorsal nerve of the clitoris is the deepest branch. It lies above the pudic vessels in the sheath of the obturator fascia, then between the two layers of the deep perineal fascia, perforates the suspensory ligament of the clitoris, and is distributed on the clitoris, where it combines with twigs from the sympathetic and forms a nervous sheath (p. 39). It supplies the constrictor urethrse muscle and the corpus cavernosum. The infei'ior pudendal na've is a branch of the small sciatic. It passes under the tuberosity of the ischium, ])ierces the fascia lata, runs between the skin and the superficial perineal fascia to the labia majora, comnmnicating with the inferior hemorrhoidal and superficial perineal nerves. I. Distribution of Orrjans between the Fascice. — The following table may help to memorize tlie distribution of the muscles, vessels, nerves, etc. of the jjerineal region : External sphincter ani muscle; Inferior iicmorrhoidal vessels and nerves; Superficial ju'rincal artery, veins, and nerves; External pudic arteries ; Superficial perineal nerves. Immediately under the skin. 112 DISEASES OF WOMEN. Between the super- ficial perineal and the deep perineal fascia. Between the two Ischio-cavernosus ) Bulbo-cavernosus v muscles; Superficial trausversus perinsei ) Pudendal sac ; Vestibulo-vaginal bulb (in a particular sheath) ; Artery of bulb; Dorsal artery of clitoris ; Artery of corpus cavernosum ; Venous ])lexuses ; ^ Superficial perineal nerves and vessels. Constrictor urethrae ^ Deep trausversus perinsei > muscles ; Constrictor vaginae J Internal pudic artery with its branches, trans- verse perineal artery and artery of the bulb ; layers of the deep ■{ Venous plexuses ; perineal fascia. Internal pudic veins; Deep perineal nerves ; Dorsal nerve of clitoris ; A^ulvo-vaginal glands (sometimes above the deep layer). Between the deep perineal and f Levator ani muscle (anterior part) ; the pelvic fascia. \ Vulvo-vaginal glands (sometimes). J. The Structural Anatomy of the Pelvic Floor. — The vagina per- forates the pelvic floor at an angle of 60° with the horizon.^ The portion in front of the vaginal slit has been called the jjubic segment, and that behind the sacral segment. The pubic segment is com- posed of loose tissue, and is loosely attached to the sympliysis pubis. (Compare pp. 89, 90, and 95.) The sacral segment is made up of dense tissue, and is firmly bound to the sacrum and coccyx. During labor the pubic segment is drawn up so that the empty bladder lies above the symphysis, while the sacral segment is being driven down by the pressure of the child. Another division of the pelvic floor is into the entire displaceable portion and the entire fixed portion. The boundary between these two is a continuous layer of loose connective tissue, beginning as the retro-pubic fat (p. 95), then forming the loose tissue on the inside of the obturator internus and upper portion of the levator ani, and finally between the vagina and the rectum (Figs. 102 and 103). The entire displaceable portion lies inside of the entire fixed portion, and consists of the bladder, the urethra, and the vagina. It has resting upon it the uterus, the broad ligaments, the tubes, and the ovaries. ' Hart is the first who has explained the structure of the pelvic floor in his re- markable thesis, The Structural Anatomy of the Pelvic Floor (Edinburgh, 1880). ANATOMY. 113 The entire fixed portion has the shape of a funnel, wide above and narrow below. It consists of tissue attached to the sacrum and the rectum, and of all tissue lying outside of the inner aspect of the levator ani muscle. K. The Function of the Pelvic Floor. — The pelvic floor counter- acts the abdominal pressure from above. The loose tissue surround- ing the bladder and the rectum allows these organs to be distended and emptied. Itfe role during the act of copulation has been referred to in describing the vulva and the vagina, and the effect of the con- FiG. 102. Horizontal Section of Pelvis at Plane of Hip-joint (Rydygier) : n, coccyx; 6, ischio-rectal fossa; c, rectum ; (/, vagina; c, bladder; /, retro-pubic fat; g, hip-joint. traction of the perineal muscles and the levator ani in narrowing the genital canal is ca.sily understood. During parturition the entire displaceable portion is pulled up- ward l)y the contractions of the muscular fibres of the utcru.'^, which are continued on the vagina (p. 50). The child is pushed tlirough the vagina, exerting a strong pressure on its posterior wall, on account of the angle between the uterus and the vagina. The activ(! and passive counter-pressure exercised l)y muscles and fii.scise (pp. 101, 10.">, 104, 10">) turn the child forward around the pubic arch. The result of parturition is, first, to dihite tlu! vagina and the vulva ; second, to tear tlu; ])erineal IkkIv more or less deeply; and third, to elongate and slacken tlu; hiyer o(" loos(? connective tissue between the entire displaceable and the entire fixed jxntion of the pelvic floor, thus predisposing to prolapsus of the vagina and the uterus. 8 114 DISEASES OF WOMEN. Fig. 103. Coronal Section of Frozen Body (Kydygier) : 1, right lung; 2, right atritim with fovea ovalis; 3, left atrium; 4, right branch of pulmonary artery; 5, arch of aorta; 6, left lung; 7, liver; 8, stomach; 9, ascending colon ; 10, bridge of tissue between stomach and duode- num left by removing pylorus; 11, pancreas; 12, duodenum ; 13,13, small intestine; 14, fundus uteri; 15, bladder: 10, obturator internus muscle ; 17, descending colon; IK, sig- moid flexure; I'J. mesentery; 20, obturator externus muscle; 21, corpus cavernosum clitoridis ; 22, meatus urinarius; 23, labia minora; 24, labia majora ; 25, femur. ANATOMY. 115 The Abdominal Regions. By means of certain imaginary lines the abdomen is divided into regions, the familiarity with which is a great help in gynecological examinations and the recording of cases. One line is supposed to be drawn across from the highest point of the iliac crest on one side to the corresponding point on the other. Another transverse line goes from the lowest point of the wall of the thorax on one side (the car- tilage of the tenth rib) to the corresponding point on the other side. Finally, a line is supposed drawn perpendicularly up from the ilio- jjectineal eminence.^ Thus nine regions are formed, the names and relations of which are seen in this table : Right hypochondriac. Epigastric. Left hypochondriac. Right lumbar. Umbilical. Left lumbar. Right iliac. Hypogastric. Left iliac. The chief contents of each region are best learned by a study of the accompanying figure (Fig. 108). If we take into consideration the weight of all the organs pressing on the bladder, it is evident that that of a slightly enlarged or simply anteflexed uterus is hardly of any account. The discomfort often complained of in the bladder under such circumstances is cither due to an affection of that organ itself or to a nerve reflex. The figure illustrates well the large amount of loose connective tissue found in the pelvis (p. 112). ' Different anatomists draw these lines somewliat differently. PART III. PHYSIOLOGY. CHAPTER I. Puberty. Puberty and the climacteric are two important epochs in woman's life, one marking the beginning, the other the end, of the fruitful period. Puberty is the change from childhood to womanhood. It is a gradual development, which generally takes place in the four- teenth or fifteenth year of the girl's life. At that time the breasts become larger, the uterus increases in size (p. 33), the hips become broader, and the contour of the whole body is rounded off. The external genitals get their growth of hair, menstruation begins, and one sex feels attracted to the other. Normal Development of Mammary Gland simulating Tumor. — When at puberty the mammary glands become the seat of greater development, it happens often that one lobule grows faster than other parts, gives rise to some pain, and becomes a little tender. Thus a more or less distinct round or oval swelling is formed, which often inspires fear and brings the young girl to the physician, who might himself be deceived and make a prognosis or even institute a treat- ment that might hurt his reputation, and, perhaps, harm the patient. It is enough to know of the frequent occurrence of such a c(nidition in order to avoid mistakes. A wet compress covered with gutta- percha tissue, or rubbing with an anodyne liniment — e. g. chloroform mixed with twice the quantity of olive oil — relieves the pain, and a good prognosis disperses the anxiety. Difference between Puberty and Nubility. — Puberty is the period when the possibility of reproduction begins, but by no means the time when it is desirable that the girl should marry and become a mother. Statistics show a very great mortality among married women under twenty years of age. It is evidently against nature's laws that women should become mothers before they are full-grown. Their uteri should have attained their maximum development, the breasts should be fit for nursing, the pelves should have reached a size that 116 PHYSIOLOGY. 117 allows the passage of a full-grown child, the muscles should have acquired strength enough to propel it, and the whole system should have been endowed with full power of resistance and endurance. It may, therefore, be stated that most women should not marry before they are twenty years old. CHAPTER II. Mensteuation and Ovulation. Menstruation is the discharge of a bloody fluid from the cavity of the uterus at regular intervals. It is also called the menses, the ^ catamenia, the menstrual period, the monthly sickness, the monthly flow, courses, or turns. This phenomenon is peculiar to woman and some monkeys.^ It is probably due to the erect position, which necessitates a harder tis- sue of the womb, and excludes the presence of the enormously devel- oped lymphatic system which is found, together with a flabby uterus, in animals whose trunk is horizontal.^ The menstrual flow commences in most women in the temperate zone between the fifteenth and seventeenth year of their life. It begins earlier in warm climates than in cold, earlier in cities than in the country, and earlier in the higher walks of society than in the lower.^ It returns in periods of twenty-eight days,^ and lasts on an average four days. The amount varies very much. Four or five ounces are said to be the average.^ It is increased by exercise, corporeal work, ehalybeates, and stimulants. The blood differs from that from other sources by a more or less considerable admixture of mucus and epi- thelial cells. It has also the peculiar "heavy" odor characteristic of the genitals. It comes from the mucous membrane of the body of the uterus and the tubes, while the cervix lias no part in the process of menstruation. Before its appearance the woman feels a certain heaviness in the lumbar region, while ])ain is always a sign of an abnormal condition. Often the breath has an un])leasant odor during 1 Bland Sutton, Brit.Gyn. .Jour., Nov., 1886, Part vii. p. 285. ■■* A. \V. .Johnstone, Arner. Gyn. Tmna., 1889, vol. xiv. p. 284. 'Special statistics are found in Hannover's Om Mcnxlruationens Betydning, Copen- hagen, 1851, ji. 18; and T. A. Emmet, The Prinriplex and Prarticr of Gynecology, 2d ed., 1880, p. 153 et mq. In a total of 2.330 cjises, Dr. p]. found the average age at the first menstruation to be 14.23 years, but, his patients being from the "better classes," this average is too low. * Most women are entirely unreliable in regard to their statement of the occur- rence of menstruation. Very commonly they state that they have it on a certain date of each month. It is, therefore, advisable for the gynecologist to keep account himself of the beginning and the end of the periods of those uiuier his treatment. Tiius many an error is proved, many a complaint settled. * Funcke, Lehrbuch der Phynioloyie, 4th ed., 180(5, vol. ii, p. '.»',)!. 118 DISEASES OF WOMEN. the period. If menstruation has been evolved from the rut in animals, it has changed very materially. While female animals only admit the male during this period of heat, woman not only has an aversion for sexual intercourse during her menstruation, but the act performed during the catamenial period exposes both sexes to dis- ease — the woman to retro-uterine hematocele, the man to urethritis and orchitis. As a rule, menstruation ceases during pregnancy and lactation, but exceptions, especially from the latter rule, are by no means infrequent. The anatomical basis of menstruation is a regularly recurrent de- velopment of the endometrium.^ About a week before menstruation Fig. 104. Uterus during Menstruation (Coiirty). Cut open to show the swelling of the whole organ, and particularly the mucous membrane : A, mucous membrane of cervix ; B, C, mucous membrane of corpus, much thickened ; D, muscular layer; E, uterine opening of tube; F, OS internum (the mucous membrane tapers down to these openings). sets in the mucous membrane of the uterus begins to swell, so that from 2 or 3 millimeters (^ inch) in thickness it becomes 6 or 7 milli- meters {I inch) thick. It acquires the greatest thickness on the mid- dle of the surfaces and fundus, and falls gradually off toward the edges (Fig. 104). Its surface becomes \,avy in consequence of the ^Leopold, Archiv fiir Gyndk., 1877, vol. xi. p. 110 et seq. PHYSIOLOGY. 119 disproportion between it and the underlying muscular tissue. Its arteries become much enlarged and form spirals. There is likewise so great a development of capillaries immediately under the epithelium that they form a plexus discernible with the naked eye. On the other hand, there are only few and small veins. The utricular glands become much wider and elongated, forming spiral- and zigzag-shaped tubes. The tissue itself is composed of connective-tissue cells inter- spersed with an enormous amount of round cells, like lymph-corpus- FiG. 105. Microscopical Section of Endometrimn of a Menstruating Woman, aged twenty, showing utricular follicles denuded of epithelium, and one still containing the epithelial east X feOO (Johnstone). cles, and giant-cells with many nuclei. According to Leopold, these cells are found in a condition of active proliferation, while, according to Johnstone, wlio has worked witli nmch more powerful lenses, the corpuscular elements arc formed from granules in tlie threads of con- nective tissue forming tiu; bulk of the mucous membrane (Fig. 47, ]). 5.j). J^efore menstruation begins tiie blood-pressure is increased (Stephenson). Some of the capillaries near the surface burst and the blocnl escapes, partly into tlie tissue, forming small extravasations ; partly on the surface, lifting uj) and tearing off the epitlielium. The ej)ithelium is also shed in that jKii-t of the utricular glands that lies nearest to the cavity of the ntei-us (1^'ig. 105). Five or six days after the beginning of menstruation the regeneration of the epithelium 120 DISEASES OF WOMEN. begins from the utricular glands. Eight or nine days after the beginning of menstruation the regeneration is already completed. The glands are no longer twisted into spirals, the arteries have become smaller, the capillary net shrinks, the scars in the capillaries heal, and the whole surface is covered with epithelium. Most of the corpuscu- lar elements have disappeared. The tubes take part in the process of menstruation. Their mucous membrane is swollen, the epithelium is shed in some places, and they are filled with a thin bloody fluid containing blood -corpuscles and cast-off epithelial cells. From this brief description of the condition of the endometrium during menstruation it is easy to draw several practical conclusions. AVe can understand how easily we can do harm by the introduction of the sound during the catamenia ; how a normal menstruation may become a pathological hemorrhage, if the woman works hard or takes much exercise ; and how the menstrual discharge may be intermit- tent — a thing that appears so surprising to many women. Ovulation. — In mammalia the connection between the processes that take place in the ovaries and in the womb are perfectly known. One or more Graafian follicles become mature and burst before each recurrence of rut. The ovum escapes into the tube and passes into the uterus, the mucous membrane of which is in a similar condition to that of a menstruating woman, ^ the tissue being full of medullary elements. If copulation takes place, the ovum meets the sperma- tozoids somewhere on this passage from the ovary through the tube to the uterus, and, as a rule, impregnation takes place. In the ovaries are found as many corpora lutea as there are fetuses in the uterus. We do not know if a similar thing takes place in women ; that is to say, we do not know if ovulation is a periodical process, and, if so, we"do not know if the cycle is the same as for menstrua- tion. That there is some connection between the two seems to be proven by the correspondence, generally admitted, between the time elapsed since the beginning of menstruation and the degree of development of the corpus luteum (p. 75). But this correspondence is denied by others, who have large experience in the removal of the uterine appendages.^ We know certainly that a single coition at any time may result in the impregnation of a woman, but the likelihood of impregnation is much greater shortly after or shortly before menstruation than mid- way between the end of one menstrual period and the beginning of the next. Of the two terms, that preceding a menstruation seems, again, to give the best chances for impregnation. Tiiis is, among other things, proved by embryology. In the young embryo the devel- 1 A. W. Johnstone, Brit. Med. Jour.. Nov., 1887, Part xi, p. .S84. 2 Lawson Tait, Diseases of Women, Philadelphia, 1889, pp. 312-317. PHYSIOLOGY. 121 opment is so rapid that an interval of three Aveeks makes an enormous ditference in the condition of the organs. In this way it was found tiiat three-fourths of young embryos corresponded to the first skipped menstruation, and only one-fourth to the end of the preceding/ The fact that a woman may be impregnated at any time does, however, not prove that an ovum is detached then, for we know that both ovum and spermatozoids may be preserved in the genital canal. The first has been found on the fourth day of menstrua- tion in the uterine part of the tube (Hyrtl-), and in another case 1^ inches above the internal os (Benham-). How long it stays in the uterus and keeps its faculty of becoming fertilized is unknown. We know as little, or still less, about the time the spermatozoids retain their fructifying power in the genitals of woman, but analogy from animals teaches that this is probably a longer one. They have been found alive in the os on the ninth day after coition.^ We can, therefore, easily imagine that in the case of impregnation taking place in consequence of a single connection in the middle of the intermen- strual period, the spermatozoids are preserved and meet an ovum detached at the following menstruation. On the other hand, it is a fact that copulation may be performed on any day of the intermenstrual period without resulting in preg- nancy. Influence of Operatioiis on Menstruation. — It is very common that during the first days after the removal of the ovaries a bleeding takes place from the uterus, even if the patient had menstruated just before the o])eration.* In some cases tlie hemorrhage occurs from other organs: I have seen it come from tiie bladder, the rectum, and the nose. This determination of normal or vicarious menstruation is probably due to the irritation exercised on the nerves in the pedicle by the tightening of the ligature. On the other hand, menstruation ceases in most cases after double ovariotomy or oophorectomy, but exceptions to this rule are by no means rare. There are cases in which menstruation is repeated \\\i\\ more or less regularity for several months or even years. In other cases menstruation does not occur during tiie first three or six months following the operation, but then it reappears for a year or two, occasionally in the shape of a severe flooding.'' ' His, Ajuitomie menxcldicher Emhryonrn, Leipzig;, 1882, ii. p. 7.'>. T\\v wliole num- ber, liowevcr, heiii}^ only Hixtoeii, this argument loses some of its \vcif;lit. '■' lA'opoJd, /. r., p. 121. •' K. IVrcy, of >i'W York, Ann'r. Jmir. Med. .91"/., July, ISTfi, p. 1")S. * In onier to avoid this extra loss of hlood, wliich in anemic patients may turn tiie fK'ales, Mr. Tail advises to operate immediately before or diirinu; menstruation (7. '., p. .H12). '(ieorge Kngelmann of St. I>ouis, "Menstruation and tin' Removal of itotli Ovaries," Trmuf. Soidhern Siirf/irtil nud (iifiircul. .{■•<for., Si'pt., LSS'.t; rejirinl, p. 1. This is not in itself a proof against the ovulation theory,. for if the [iresence of a 122 DISEASES OF WOMEN. At the time the extra-peritoiieal treatment of the pedicle was yet in vogue I saw menstruation after ovariotomy accompanied by bleed- ing from the tul>e in the stump. With the present intraperito- neal method there may, therefore, occasionally occur a retro-uterine hematocele under such circumstances. According to Tait, the removal of the Fallopian tubes is of much greater importance in bringing on the menopause than that of the ovaries ; but it is not unlikely that the influence of the removal of the tubes is again due to a large nerve-trunk which is seen running to the uterus in the broad ligament, in the angle between the round ligament and the tube.^ When the object of the operation is to bring on the menopause, special care should, therefore, be taken to go close up to the uterus and include this nerve in the ligature ; and in cases in which the removal of the uterus or its appendages proves impos- sible, it is advisable to ligate the tubes, including the nerve. Theory of Menstruation. — The cause of menstruation is unknown. Most likely it has a yet unknown centre in the central organs of the nervous system. According to Johnstone, menstruation is a necessity in women and erect animals, because there are not sufficient lym- phatics to carry off the lymph-corpuscles. The uterus is, according to him, a hollow lymphatic gland without a lymph-stream, and his definition of menstruation is, "a periodical washing away of those corpuscles which are too old to make a placenta." (Compare p. 51, foot-note.) If there is any connection between ovulation and men- struation, both are controlled by a common impulse from the central nervous system. In some patients I have observed that alternately one and the other ovary undergoes a regular swelling at the time of every menstruation, but whether the same is the case in healthy women I do not know. third ovary of the size of the .normal ones is so rare as not to count in this connec- tion, small supernumerary ovaries have been found twenty-three times in 500 bodies (Beigel i. Another explanation is that a part of the two large ovaries has been left behind — a thing that sometimes is unavoidable. But perhaps the presence of ovarian tissue is not needed at all for the recurrence of menstruation. Tait has seen menstruation recur regularly for many years in a case of Porro's operation in which ovaries, tubes, and most of the uterus were removed (/. c, p. .320). Eut can also occur in animals after complete removal of the ovaries (Barthelemy, Jour, de Mede- cine reterinaire ; Med. Record, Sept. 27, LS90, p. 368). ^ Johnstone, Brit. Med. Jour., Nov., 1887, p. 387. PHYSIOLOGY. 123 CHAPTER III. Copulation. Copulation is the act by which the male and female bodies are sexually united. Under normal circumstances it is preceded by sex- ual appetite or desire. All its phases, perhaps with the exception of the desire, seem to be much less pronounced in woman than in man. The clitoris, the vestibulo-vaginal bulbs, and perhaps the inner geni- tal organs enter into a state of erection. Friction between the male and female copulative organs causes a peculiar pleasurable sensation, which ends in orgasm, the acme of nervous excitement, which seems to be weaker in the female than in the male, and is altogether absent in some women, who neverthele&s are capable of being impregnated. The orgasm is accompt^uied by an ejaculation of a mucous fluid from the glands of the vulva. If orgasm is less pronounced than in the other sex, it leaves far less feeling of exhaustion than in man. It is followed by relaxation which at any time may again give place to new excitement and erection. This ditference is easy to understand when we take into consideration the difference between the fluids ejaculated and the profound shock sustained during orgasm by the central ner- vous system in the male. The disturbance of these normal conditions which makes copulation painful or impossible is called dysparcunia,^ and may be caused by many different affections or malformations of the genitals or other organs. CHAPTER IV. Fecundation. Fecundation, or fertilization, is the union of the male and the female generative elements, the spermatozoid and the ovum, l)y which in the latter commences the formation of a new individual. It is likely that the two elements, as a rule, meet in the tubes, although the well-authenticated phenomenon of ovarian pregnancy proves that the combination may take place in the ovary, and in mainnialia the spermatozoids are found on it within twenty-four hours after coition. ^ Kolx;rt I'>.'irnes, A Cllnmd History of the Medical ami Sur(jical Disensta of Women, London, 1878, p. Gl. 124 DISEASES OF WOMEN. In animals the ovum is no longer capable of fertilization when it has Fig. lOG. \T v"' d; :co ;j»v!° v «•? ' v.'j ^■ Portions of the ova of Asterias glacialis, showing the approach and fusion of the spermatozoon with the ovum (Hertwie) : a, fertilizing male element ; b, elevation of protoplasm of egg; 6', 6", stages of fusion of the head of the spermatozoon with the ovum. left the upper part of the tubes. It seems, therefore, highly improb- FiG. 107. Fertilized Ova of Echinus (Hertwig): ^, The male (a) and the female pronucleus (b) are approaching; in B they have almost fused. C, ovum of Echinus after completion of fertilization ; s.n, segmentation-nucleus. able that in woman the ovum should retain the possibility of being PHYSIOLOGY. 125 fecundated for weeks after it has left the ovary, whilst no fact is known that would conflict with the supposition that the sperniato- zoids keep their vitality for weeks in the folds of the ampulla, and, on the contrary, such possibility is absolutely proved in animals/ If union of the two elements took place in the cervix, the ovum would be lost, as this part of the uterus is not fit for the formation of a placenta. Observations on animals make it highly probable that a part of the spermatozoid enters through the zona pellucida and combines with the germinal vesicle (p. 74), so that the formation of the new individual begins by the physical union of material derived from the father as well as from the mother (Figs. 106 and 107). This leads ns at least one step farther in the comprehension of the won- derful transmission through heredity of physical and mental peculiarities, aptitudes, and acquired talents, as well as diseases, from the father to his offspring. The ciliary movement is directed from the fimbriae to the internal OS, so that it pushes the ovum through the tubes and the uterus, while the spermatozoids move against the current. CHAPTER V. The Climacteric. The climacteric — also called the menopause, or change of life — is the end of the fruitful part of woman's existence. Like ])uberty, it is not a momentary nor a single event. It comes on gradually, ex- tending over a period of two or three years, and if the cessation of menstruation is the most characteristic symptom of it, it reverberates through the wiiole system, causing considerable })hysical and mental changes. It comprises the time when menstruation begins to be irregular, gradually diminishes, and finally ceases altogetlier. In most women the menopause suj)ervenes when they are from forty-five to fifty yeare old, and the length of the fruitful period is in most women thirty-four years. Those who begin to menstruate early (under sixteen veal's) continue, as a rule, longer than those who have their first menstruation late (after sixteen). To tiiis rule there is only one exception, and that is due to the influence of climate : in cold cli- mates menstrual life begins and ceases late, while in hot climates ir begins and ceases early. Tlie fruitful period is longer in those avohicu who have borne children and mu'sed them themselves than in nul- lilKine and those who have not mu'scd their children. On the other hand, early sexual intercourse and a rapid scciuence of childbirths or mis("arriages shorten the pericMl of fertility. It is shorter in the labor- * His, Aiuitomic meiuiclUicher Embnjoncn, Leipzig 1880, i. p. 1()7. 126 DISEASES OF WOMEN. ing classes than in women who lead an easy life. It is likewise shorter in fat women than in thin, and shorter in weak women than in strong. Those who suffer from chronic metritis or are weakened by uterine hemorrhages arrive sooner at the menopause than healthy women. Often it is brought on suddenly by severe diseases, such as cholera, typhoid fever, malaria, or a fall, a blow, a great fright, or deep mental depression. Such sudden entrance of the menopause is, as a rule, accompanied by especially violent disturbances in the whole organism, and it is therefore much better for a woman when it comes on gradually. The most serious side of the climacteric is that it is the time when carcinoma most frequently appears in the uterus or the breasts. The fii'st symptom of the approaching menopause is irregularity in the menstrual flow in regard to time and quantity. As a rule, the interval between two menstrual periods becomes longer — say, six or eight weeks — but sometimes, on the contrary, menstruation becomes more frequent. The quantity of the discharge diminishes, but occa- sionally profuse hemorrhages occur. Menstruation lasts longer — say six or eight days. Most of the accompanying symptoms may be referred to active or passive hyperemia (congestion or stasis). Thus we find congestion in the head, causing a red face, headache, indis- tinct vision, a buzzing sound in the ears, vertigo, restless sleep dis- turbed by harassing dreams, and bleeding from the nose. The passive hyperemia of the intestinal tract produces catarrh of the stomach and of the intestine, hyperemia of the liver, with icterus, swelling and bleeding of the hemorrhoidal veins. The hyperemia of the lungs causes bronchial catarrh and attacks of dyspnea. That of tiie kidneys shows itself in sediment in the urine. Leucorrhea is very frequent. The skin is frequently the seat of flashing heat and profuse perspira- tion. Acne rosacea appears often in the face ; there may be intoler- able itching, burning, or smarting sensations all over the body, and the vulva may be the seat of a most distressing pruritus. The nerv- ous system shows signs of a profound shock. Besides the symptoms already mentioned in reference to the head and skin, the patient often com])lains of backache and neuralgia ; sometimes tremor occurs in her limbs; she suffers from palpitations; her temper is subject to great and sudden changes ; the sexual appetite is often inconveniently increased ; and she may become delirious or even insane. A peculiar functional affection of the heart has been observed : it is characterized by palpitations, dyspnea on exertion, a feeling of dis- tress in the region of the heart, faintness or syncope, a very rapid pulse without any rise in temperature, edema at the malleoli and the hypogastric region, and pallor of the face. The attacks usually last a week. The disease begins and disappears gradually. The whole appearance of the person changes often at the meiio- PHYSIOLOGY. 127 pause. Most women become stout, but some lose flesh. Sometimes gout makes its appearance. Important anatomical changes take place in the genitals. The uterus becomes atrophic. Sometimes the external or internal os or both close, and if at the same time there is catarrh of the mucous membrane, the mucus accumulates, forming hydrometra, or, if gases are developed in the fluid, physometra. If both the internal and external os close and a catarrhal discharge takes place both in the body and the cervix, a characteristic swelling is formed, composed of two globes separated by a transverse furrow [uterus bicamei-atv^ vetularum). The mucous membrane becomes thin and loses its cor- puscular elements (Fig. 51). Sometimes a vessel ruptures in the fun- dus or posterior wall, causing an extravasation of blood ((ipoplexy of the uterus). The ovaries become small and hard ; the epithelium is lost on large areas ; the follicles disappear, and are replaced by dense fibrous con- nective tissue. The tubes become both thinner and shorter, and not seldom the walls grow together in different places. In the breasts the glandular tissue disappears, and they become atrophic, or if they retain their size, or even become larger, it is due to the development of fat. Sometimes a serous fluid is found in them before the gland has all been absorbed — a circumstance which, to- gether with abnormal sensations in the abdomen, tympanites, and the cessation of the menses, often lead tiie patient, and sometimes the piiysician, to the erroneous belief that she is pregnant. Treatment. — Although the climacteric is a physiological j)rocess, normally occurring in every woman's life if it is sufficiently extended, the dangers with which it threatens are so serious, and the normal condition passes so easily and frequently into the domain of dis- ease, that the j^hysician is often consulted about it. The treatment of the real diseases conne<'tod with it will be discussed in later chap- ters, under the diseases of the diflerent organs affected, or must be looked for in works on the practice of medicine. Here we can only indicate a few ])oints, especially in reference to hygiene. A chief point is to keep the bowels open, preferably by means of aperient Siilts or waters. Sometimes enemas of plain water or muci- laginous aiid oily substances or glycerin may advantageously be com- bined with or substituted for the a])erient medicine. Derivation to the skin by washing the whole body with cold water and rubbing the skin well with Turkisii t<nvels is both ])leasant and useful. For the loaded urine it is well to driidv a syphonfnl of Vichy, Rhcns. or Scltser water in tlie cour-^c of the day, or to take bicarbonate o(" soda (3SS t. i. d.) in a tumblerful of water. The congestion of llir head and visual disturbance are often much benefited l»v the use oi" 128 DISEASES OF WOMEN. hot foot-baths, with or without mustard, of the cold eye-douche five minutes tliree times a day, and of scarification of the cervical portion. A glycerin pledget introduced morning and evening into the vagina may also relie\'e congested organs by causing a watery discharge. A lukewarm general bath taken two or three times a week keeps the skin in good order and tranquillizes the nerves. The diet should be bland, but must vary according to the constitution. In those women who have a tendency to stoutness it ought to be as much restricted as possible, and all fat-producing food (cereals and sugar) ought especially to be taken in very small quantities; milk and beer are prohibited. Fish, meat, green vegetables, lettuce salad, and juicy fruits ought to constitute the bill of fare. Tea and coffee ought only to be taken weak. Upon the whole, the less the woman drinks the better, for even water makes her fat. Alcoholic stimulants are best avoided altogether, but if there are special indications making their use desirable, or the patient has a craving for them, a light acid white wine (Moselle), mixed with plain water or a mild alkaline water, will do least harm. When the stoutness takes the proportions of pronounced obesity, a still stricter diet is necessary (Banting cure), and special treatment at certain mineral springs (Carlsbad, Marienbad, Tarasp) may be indicated. Those more exceptional women who lose flesh, must be well fed and have chocolate and plenty of milk to drink, if they can digest them. Cereals ougiit to be a chief part of their diet-list, but all sorts of animal food ought to be given besides. As a sudden suppression of the menses is particularly dangerous, the patient ought to take special precautions in that respect during the climacteric. She must beware of cold feet or a wet skin when she has her menses, not wash the genitals with cold water, and still less take a cold bath when the menses are present. As congestion of the pelvic organs might cause hemorrhage, she should abstain from sexual intercourse. When first the menopause is well established marital relations may be resumed without danger. The mental diet is of no less importance than the physical. The physician may relieve much unnecessary anxiety by giving a good prognosis. The patient should occupy her mind by useful work, and exercise as much self-control as her mental condition and acquired habits will allow. When hemorrhage supervenes, it ought to be checked just as under other circumstances when a proper amount of blood corresponding to a menstrual period has been discharged. For this purpose we use hot douches, an ice-bag over the hypogastric region, tamponade, and drugs that have that effect (see Menorrhagia) ; and tlie patient ought to be kept in bed lightly covered in a cool room, and on cool, spare diet. The above-mentioned menstrual cardiopathy is treated with digitalis and other heart tonics. PART IV. ETIOLOGY IN GENERAL. The causes of gynecological diseases may be divided into predis- posing and exciting. Predisposing Causes. — The first class, although more remote in their effect, are more important on account of their frequency. Heredity may play a double role, either that the same defect that is found in the mother is transmitted to her daughter, especially mal- formations and malignant diseases, or that the child inherits a gener- ally weak constitution from one or both of her parents, which, in combination with her sex and the other predisposing factors, gives rise to diseases of the genitals and pelvic organs. In the latter respect it must be noted that children of parents advanced in life at the time of their procreation as a rule are less vigorous than those engendered in younger years. Education has great influence in the development of gynecological diseases. Too great assiduity in study in early youth concentrates the nerve-energy on the brain, and deprives the uterus and ovaries of their share at a time when these organs are undergoing an enormous develo})ment, and preparing for the important functions of womanhood and motherhood. Too great interest in and practice of music, i'rom its profound effect on the emotions and the constantly repeated physical thrill in the nerves, is particulary dangerous. Everything that causes active or passive hyperemia of tJie pelvic organs is a source of disease. In tiiis category belongs sexual ex- citement brought on by reading prurient novels ; l)y looking at obscene pictures; l)y seeing representations on the stage that aim at the exposure of so much of the body as existing laws and public opinion will permit; by masturbation, sa})pliism (tiie same as tribad- ism), sodomy, and even normal coiton if performed too violently. Tlie neglect of the skin, by which one of the chief enumctories is nearly blocked up, is hardly ibund in the better classes in this conn- try, i)ut is exceedingly common among the jjoorer women, es[)ecially immigrants, of certain nationalities.' Ins^ijficirnt exercise and lavl: (f open air are a IVeijuent cause of" dis- ease, and favor th(! stagnation of blood in the pelvis; l)ut in this ' The .Jewesses from Russian Poland in my dispensary experience exceed all others, and make, in fact, the impression of never bathing or washing their body. 9 1 L'l) 130 DISEASES OF WOMEN. respect, as also in regard to food, a great change has taken place in the higher classes during the last decade. The ideal of the American girl is no longer to be thin and pale. The young men having taken an ever-increasing interest in athletics and all sorts of sports, most of which are cultivated in the open air, the girls do not want to stay behind. The dull croquet has speedily been followed by the lively tennis; muscular strength is developed by swimming, riding, fencing, skating, and ballet-dancing ; and now the girls begin even to have gymnasiums of their own, where every part of the body may be developed by properly adapted exercises. In regard to food there is also great improvement, but still it is often necessary to preach the importance of taking a proper amount of good, wholesome nutriment. Many girls have a loathing for food in the morning, and will, if allowed to do so, go to school Avith an empty stomach, and let their brain work for hours before they take any substantial food. A very bad habit, that spoils the appetite, causes a sour stomach, and in consequence impoverishes the blood and gives rise to nervous troubles, is the immoderate use of candy, which among women and children corresponds to alcoholic beverages and tobacco in men. A fruitful source of disease among Avomen is the lack of attention to the excretions. The vast majority of gynecological patients suffer from constipation. They will go for days — nay, sometimes a whole week — without a movement of the bowels. This accunuilation of feces gives rise to local trouble by pushing the uterus out of its place and interfering with the free circulation of the blood in the pelvis ; but, besides, it causes absorption of the gaseous and liquid part of the fecal material, that shows its deleterious eifect in bloodless lips, headache, neuralgia, and fatigue. The excretion of the urine is no less neglected. The requirements of polite society will often prevent women from emptying the bladder in time, which may lead to paralysis of that organ, not. to speak of rupture, and not unfrequently is the cause of cystitis and neuralgic pain, besides predisposing to uterine disease by pushing the womb out of j)lace. The mode of dress in r/, although changingunder the varying caprices of fashion, is always fundamentally wrong and conducive to disease. The " decollete " evening dress and the bell-shaped nether garments drive the blood from the periphery to the pelvis. The lower part of the abdomen is generally insufficiently protected from cold air and blasts of wind, which become particularly dangerous to women who skate. High heels, when Morn at an early age, while all articulations are yet subject to change, not only alter the shape of the foot, but are apt to cause neuralgia in the legs and a change in the inclination of the pelvis and the normal curvature of the back.^ ^ S. Eusey, Trana. Amer. Gyn. Sue, 1882, vol. vii. pp. 248-261. ETIOLOGY IN GENERAL. 131 Of much greater importance yet is the use of corsets. Even a loose corset exercises a pressure of 30 pounds, which has still greater effect on the abdominal cavity than on the thoracic. The abdominal wall is thinned and weakened. In the erect posture the liver and intes-. tine are pushed forward, driving the weakened abdominal wall in front of them, and in sitting the normal pressure backward from the abdominal wall against the spinal column is changed into one going directly down into the pelvic cavity. By tight lacing the pelvic floor is bulged down to the extent of one-third of an inch.^ Late hours, social gatherings beginning at the time when the girl ought to go to bed, have a very bad effect on the nervous system, and predispose to much greater suffering from actual trouble than is felt by those leading a more natural life. Neglect during menstruation seems to be a fruitful source of female complaints. Women not only move about, but dance and skate, at a time when a process is going on that is so easily turned in an abnor- mal direction. We have seen in the chapter on Physiology how differently women are constructed from men in regard to sexual excitement. It is very unlikely that the mere frequency of normal sexual intercourse does a healthy woman any harm, but it is quite different when the natural relations are disturbed. The sin of Onan,^ sodomy, and even the use of condoms, injections made in a hurry immediately after ejaculation at a moment when nature calls for rest, and often with a fluid of improper temperature, all cause a tension of the nervous system and a congestion of the genitals Avhich in the course of time result in liemorrhage, leucorrliea, chronic metritis, fibroids, or other affections. Marriage with existing disease of the pelvic organs often lays the foundation of much wretchedness for both husband and wife. If a flexion of the uterus may be cured by childbirth, provided conception takes place in spite of it, how different is it when the ovaries or tubes are the seat of chronic inflammation, which causes excruciating pain at the mere toucli during a (;areful examination ! If married life has its dangers, celibaci/ does not offer entire pro- tection. Esi)ecially is the liability to the formaticm of fibromas of the uterus greater in unmarried and imllijxarous women than in those who have borne children, as if the uterus, deprived of the function of building up a new being, were more liable to use the material for the formation of a tumor. ' The question of the eflert of tlie corset and otlier wearing apparel has been ably discussed by Dr. Kol)ert L. Dickinson in tiie Nnn York Med. Join:, Nov. 5, ISST, Hare's Syslcin of Tlimtpi'iilirji, vol. iii. pp. 7o()-7.S4, and Trans. Aiiirr. (lyn. Sue., IS',);-}, vol. xviii. pp. 411-4.>S. ' A carefnl perusal of Genesis xxxviii. 9 will convince the render tliat tlicrfby is not meant the vice which erroneously lias been named sifter that man, and whicli properly is called masturbation, but the practice commonly known as " witlidrawul.'^ 132 DISEASES OF WOMEN. In married, as well as unmarried women, the climacteric predis- ])()ses to ilisease — a point wliich has been considered in a previous chapter (p. 126). Exciiing causes. — Sometimes a faulty development- of the fetus constitutes a disease. Too great closure of the two halves forming the body gives rise to atresia ; too little, results in hypospadias, epispadias, or extroversion of the bladder. Arrest of development may also cause an infantile uterus. The genitals may be more or less completely absent. These conditions will be discussed under the diseases of the special organs. Coition during menstruation has often been the cause of retro-uterine hematocele. Childbirth is a fruitful source of disease to women, sometimes with- out, but ofteuer with, fault on the part of the obstetrician. Tears of the vaginal entrance often lay the foundation of prolapse of the vagina or the uterus. A torn cervix gives rise to ectropion of the nuicous membrane, leucorrhea, hemorrhage, cystic degeneration of tlie cervix, secondary sterility, neuralgia, impaired nutrition, and carcinoma or sarcoma of the uterus. Too early rising after confinement, while the uterus is still large and soft, often causes subinvolution or displace- ment of that organ. ^ Through deficient antiseptic precautions inflam- mation is started in the uterus, the tubes, the connective tissue of the pelvis, or the peritoneum — conditions which, if they do not end the patient's life at once, often leave her sterile or a sufferer for life. Abortions, spontaneous or legitimately induced to avert greater evil, may give rise to diseases calling for the gynecologist's inter- ference ; but of by far greater im])ortauce is the criminal abortion so frequently resorted to by women in all classes of society, in the coun- try as w'cll as in cities. Sometimes the ignorance and recklessness of the abortionist go so far that he makes a hole in the uterus through which one can put one's thumb, and through which the intestine may find its way into the vagina and down between the thighs;^ and it is by no means rare to read in the reports of coroners' autojisies in suits for malpractice that wounds inflicted with some sliarj) or pointed instrument are found in the genitals of those who have suc- cumbed in consequence of criminal abortion. But, even apart from these surgical injuries, there are two immediate dangers of abortion — namely, hemorrhage and septicemia, which are due to retention of the whole or part of the ovum. Hemorrhage occurs in two forms : either in the shape of sudden considerable flooding or as a constant or frequently-repeated loss of small amounts of blood, which is due ' This question has been considered at length in my article "Eest after Delivery," Amer. Jour. Obstetrics, vol. xiii. No. iv. Oct., 1880, pp. Sol-SOS. ^ Cases of this kind were reported by Thomas and Xoeggerath in the Obstetrical Society of New York, Amer. Jour. Obstet., 1882 (Supplement, pp. 4-6). ETIOLOGY IN GENERAL. 133 to fungosities of the endometrium, and undermines the most robust constitution. The more remote eiFects of abortion are similar to those of too early rising after childbirth, especially subinvolutions and displacements.^ Gynecological J/"€a^?>ien^.— Unfortunately, our list of the chief direct causes of gynecological diseases would be incomplete, if we left out the gynecological treatment itself. Even with the greatest care, our procedures are frequently not free from danger, and, if we ne- glect antiseptic precautions, the danger increases manifoldly. Espe- cially is all intra-uterine treatment Mitli sounds, curettes, tents, dilators, and pe&saries'^ fraught with danger on account of the absorption of septic material, which so easily takes place through the lymphatics Df the endometrium. Gonorrhea. — Greater than any other danger is, however, sexual intercourse with a man who has gonorrhea, or who has, perhaps, had one many yeare ago which has not been thoroughly cured. AVhile a gonorrhea in man in most cases is a trifling disorder, although excep- tions, in which it leaves a serious condition, and even becomes fatal, are not so very rare, in women it is one of the most serious diseases. If it only affects the vagina and the urethra, it is of less consequence. It is already more serious if it extends into the vulvo-vaginal glands, but if it works its way up through the uterus to the tubes, ovaries, and pelvic peritoneum, it jeopardizes not only the woman's life, but, if she survives, she is most frequently left sterile, and is often an invalid for life, being subject to a chronic inflammation of the tubes and ovaries, with frequent acute attacks of peritonitis and an incur- able uterine catarrh due to reinfection from the tubes. If sterility does not follow, such women often have an attack of puerperal endo- metritis in every confinement. Under the name of Intent r/onorrhca has been described a condition in which a woman is infected by a man who had a gonorrhea months or years before. Xo acute gonorrhea is pnxlueed, but the women become ailing, remain sterile, and are affected with chronic, subacute, sometimes acute, very often relaj)sing, inflammation of the internal genitals.^ ' An interesting paper on "Abortion and its Eflects" was read by Dr. J. T. John- son of Washington, D. (;., l)efore the Medical and Chirurgioal State Faculty of Maryland, on Aj)ril 23, 1890 {Marj/lnnd Miil. Jour.). '(Jarrigues, "Danger of Stem Pessaries," Amer. Jour, ObMct., Oct., 1879, vol. xii. p. 756. ' Emil Noeggerath, "Latent Gonorrhea," Trans. Amer. Gyn. Soc, 1876, vol. i. p. 268, et seq. PART V. EXAMINATION IN GENERAL. The examination of a gynecological case is verbal and physical. Verbal Examination. — The aim of this work being to offer a prac- tical guide for general practitioners, I shall not expatiate about all that we might be led to surmise by a number of symptoms elicited by a protracted conversation — conundrums that, anyhow, only find their solution by a physical examination ; but I shall briefly state the questions I ask a patient before proceeding any further. Age. — The age ought to be ascertained, because it often gives a measure of the weakness or robustness of the constitution of the pa- tient, may throw some light on the nature of the affection for which she consults us, and may give us a hint in regard to special epochs in her life, such as puberty or the climacteric. Social Position and Pursuits. — It is useful to know whether we have to do with a society lady, whose greatest fatigue is her social obligations ; a shop-girl, who is kept standing or tripping about all day long ; or a washerwoman, who stands bent over tlie tub rubbing linen day after day. It is of importance to know whether the patient spends her day in studying or in artistic pursuits — conditions which, as a rule, are combined with a highly-developed but over-sensitive nervous system. It is necessary to know something about the finan- cial resources of the patient. In the poor recourse to more radical measures is often imperative, while those who possess adequate means may be benefited by a less vigorous but more protracted treatment. Duration of Sickness. — The knowledge of the length of time during which the patient has been sick teaches us at once whether we have to deal with an acute or a chronic disease. Condition. — It is of the very greatest importance to know whether our patient is single, married, or a widow, or has sexual connection without being married. If she is married, we want to know how long she has been so. ChildbirtJi and 3Iiscarriages. — Next we want to know how many children she has borne, the age of the oldest and the youngest, and if she has had any miscarriages. A rapid succession of pregnancies 'is in many cases an important etiological point. Often the disease for which we are consulted may be referred to the last confinement or an instrumental delivery. If she is sterile, we must find out if it 134 EXAMINATION IN GENERAL. 135 is a natural condition or due to the use of preventives. If we find sterility combined with dysmenorrhea, we nearly always find a Hexion of the womb, and most frequently an anteflexion, often com- bined with a narrow os. If there have been many miscarriages, we must ask if they were spontaneous or induced. If criminal abor- tion has been performed, that often gives the clue to the origin of the disease, while, on the other hand, repeated spontaneous miscar- riages are generally due to a misplacement of the uterus or to syphilis, either in the patient or her husband, or both. Menstruation. — The normal period is twenty-eight days, of which menstruation lasts four (p. 117). Some women have periods of twenty-seven or twenty-nine days ; some even of only three weeks. The duration varies likewise a good deal within normal limits. Some women menstruate only a day or two, others for a whole week ; but, as a rule, such conditions are allied to symptoms which show that we have to do with something abnormal. The amount of blood lost at the menstrual period is of greater importance than its duration, since one will lose more in a day than another in a week. As a rule, women are able to tell whether they lose much or little, even if they do not use najikins, the number of which often is given as measure of the amount of the discharge. Normally, menstruation is only preceded and accompanied by a feeling of heaviness, especially in the loins. Menstrual pain is always a sign of disease. If it precedes the flow for many days, it is probably of ovarian origin, while a pain felt for a day and relieved by the flow is in most cases referable to a flexion of the uterus, and a pain continuing during menstruation points toward a diseased condition of the endometrium. If menstruation is absent, we ask if it has ever been established. If it has not, we must take the patient's age into consideration (p. 117) and ascertain if she has molhainn — /. e. if at regular intervals of four weeks she suffers from abdominal pain, cerebral congestion, and general malaise. If tiie patient has reached the age of puberty, is otherwise well developed, and has monthly moliniina, a physical examination is imperatively called for, in order to find out whether some malformation forms a barrier which prevents the blood from escaping from the genitals. We nnist inquire if the patient is subject to a regular bleeding from other parts which might have the charac- ter of a vicarious menstruation (Part VII., Chap. II.). If n)enstruation has been established, we must ask if it is the first time it has failed to appear, or if similar periods of amenorrhea have preceded. We must ask if it lias been suddenly suppressed, and if any cause for such suj)pression is known — r. 7. exj)osure to cold. Under all circumstances of disapj)earance of the menstrual flow the physician must think of the possibility of pregnancy, and iiKpiire about nausea and vomiting, and if tiie pati(Mit is unmarried, under 136 DISEASES OF WOMEN. some plausible pretext, obtain an examination of the breasts, which may give such corroborative information that a vaginal examination must be proposed. Even with married women he must remember that they may be pregnant without knowing it, or may be led by the secret desire that something may be done that will put an end to their pregnancy. So-called menstruation recurring a year or more after the meno- pause is very suspicious, as it is generally a hemorrhage caused by cancer. Discharge. — We ask the patient if she has any discharge from the genitals between her periods, and if so what color, consistency, and odor it has. A discharge is always an abnormality. A white, milky discharge is of least importance ; a thick, glairy one comes from the cervix, and is often hard to cure ; a bloody one comes probably from ulcere or granulations ; a purulent one is a sign of a deeper inflam- mation, which often is of gonorrheic origin, or it may come from ulcers ; an oifensive one often is a sign of cancer. 3Iicturition and Defecation. — After these questions about the geni- tals proper we inquire about the condition of the neighboring organs. Very often we find frequent or painful micturition, even without disease of the urinary organs, and constipation. Pain. — The symptom that most frequently brings the patient to seek help is pain. The pain has certain places of predilection, which, according to decreasing frequency, may be arranged in the following list : the left iliac fossa, the right iliac fossa, or both ; backache, pain under the left breast, pain in the epigastric region, headache, neuralgia on the anterior surface of the thigh (anterior crural nerve), neuralgia on the external surface of the same (external cutaneous nerve), pain in the coccygeal region or in the interior of the pelvis when sitting. As a rule, the pain is increased by walking or other exertions. Fre- quently coition is painful (dyspareunia). When a pain is felt on one side of the body, it is, as a rule, on the aifected side ; but some- times it is referred to the opposite side. Other al)normal sensations, such as itching or burning, are some- times worse than real pain. Sometimes patients suifer from a pricking pain in the eyeballs, with weak eyesight (asthenopia), palpitations, and the different nervous symptoms known as hysteria. Nutrition and Strength. — Most frequently gynecological patients are thin and anemic, their appetite is poor, and they suffer from dys- pepsia. They complain of feeling tired, and are unable to do the same amount of work as l)efore they were taken sick. Family History. — Sometimes the family history helps to a diag- nosis, especially in regard to hereditary predisposition to such dis- eases as tuberculosis and cancer. EXAMINATION IN GENERAL. 137 Special Questions. — In special cases many other questions suggest themselves. For instance, if the patient has an enlarged abdomen, it is of great importance to know in what locality the enlargement was first noticed. If during the physical examination we find great tenderness in a married woman, it is a pertinent question to ask if coition is painful, and, if so, how often it takes place. When there is a deficient development of the genitals, it is proper to ascertain if tiie patient has a normal sexual appetite and feels normal satis- faction in sexual intercourse. Venereal affections call for a close examination in regard to the time of their first appearance, preceding or concomitant symptoms (ulcei-s, rash, sore throat, alopecia), and the health of the husband. Sometimes it becomes necessary to ask the patient if she masturbates, which usually can be done by asking if she suffers from heat in the genitals, if she touches them, if she scratches hereelf, and so forth. But all such special questions will, as a rule, best be put during or after the j^hysical examination. Physical Examination. — For the physical examination we must make use of four of our senses — viz. sight, touch, smell, and hearing — and certain instruments or apparatus. Most examinations can be satisfactorily made with the patient lying in her bed or on a lounge, and in private practice, in the home of the patient, most examinations are made in this way. Certain things are, however, felt much better, or are first brought out, when the patient lies on an even, unyielding surface, and office practice is much expedited by having a couch especially made for the purpose. There are numerous examining chairs and tables in the market and in more or less common use. Tables are by far to be preferred to chairs, the latter not allowing so easily and so completely a change from the dorsal to the lateral })os- ture. A common table with a hard mattress may be used, but it is a Fig. 108. great improvement to have a table that can easily be made to slant backward, and to that side which is to the right of the physician when he stands at the foot of the table and turns his face to the patient. The most perfect table is, I believe, Daggett's, of Buffalo, N. Y. (Fig. 106). Whatever table is used shoukl be jilaccd near a window, with the foot end turned toward as g(x>d a light as can be obtained. Daggett's ruble. The bladder and the rectum must be empty. If the bladder is more or less full, the urine in;iy be drawn when the patient is on the tal>le. If the rectum is loaded, it 138 DISEASES OF WOMEN. is better to postpone the examination until the intestine has been emptied by means of an enema and an aperient. By neglecting these precautions the beginner may fall into serious errors, such as to dia- gnosticate pregnancy or tumors that are destined to disappear with a movement of the bowels. I. Positions. — The two chief positions used for examining a gynecological patient are the dorsal and Sims's. Of less importance are the genu-pectoral, the erect, the ventral, and the elevated-pelvis positions. The Dorsal Position. — The patient lies on her back, the head slightly raised on a cushion, the knees drawn up and widely sepa- FiG. 109. Dorsal Position. rated, and the heels placed on the table or in front of it or above its foot-end in some kind of holes or stirrups (Fig. 109). The skirts are pushed up on the abdomen. For a complete examination of the abdomen the corset must be removed, and all bands round the waist opened, but for an exploration of the pelvic cavity we need only insist on the removal of closed drawers. In this way we save much time and cause the patient less trouble. When she is in position, she should be covered up to the breasts with a sheet, which thereafter is folded in between her legs, so as to leave only the vulva exposed. EXAMINATION IN GENERAL. 139 If no inspection is intended, but only a digital examination, the patient remains entirely covered under the sheet. The modification of the dorsal position called breech-back position will be described under " Preparation for Operations in General " and under " Urinary Fistulse." Sims' s position (Fig. 110) is a position on the left side, but every left-side position is by no means Sims's. In the later the patient lies on her left side half turned over on her front. The left side of the face rests on a cushion ; the left breast touches the table ; Fig. 110. the left arm is placed behind the body ; and, if the table is narrow, both arms hang down beside it, but if it is too broad, tlie riglit fore- arm and hand may rest on the cusliion in front of the face ; the nates form an inclined plane, the right being a little nearer tlie head and in front of the left; the riglit leg lies on the left, but is drawn a little higher up toward the pelvis. These two positions should be used in every case at the first exam- ination. The dorsal ])osition is the b(!st for bimanual examination, for the use of the j)lurivalve specnlum, and for the examination of the alxlomen. Sims's position allows ns to introduce one or two fin- gers much higher up behind the uterus than when the j)atient is in the dorsal position. Kven things in the anterior j)art of the pelvis 140 DISEASES OF WOMEN. are sometimes felt better ; for instance, an anteflexion which cannot be made out while the patient is on lier back, may become quite plain when the l)eut uterus falls forward over the tip of the examining finger in Sims's position. The chief advantage of this position is, however, that it admits of the use of Sims's speculum, and is prefer- able to others in certain operations. The genu-pectoral position is rarely used for diagnostic purposes, but is sometimes useful in replacing a retroflexed gravid uterus, or a prolapsed ovary. The patient rests on her knees, the upper part of the chest, the right side of the face, and the right forearm (Fig. 111). The thighs are kept perpendicular and the back hollowed. The erect position is useful in order to ascertain if there is any pro- lapse of the vagina or uterus. The patient stands with the feet about Fig. 111. Genu-pectoral Position (H. F. Campbell). half a yard apart, slightly bent forward. The physician sits in front cf her and introduces the index-finger into the vagina. The elevated-pelvis position^ (Fig. 112) is sometimes useful in deter- mining the connection between an abdominal tumor and the pelvic organs. The patient lies on her back on a strongly inclined plane, with much elevated pelvis, the knees are bent and her legs are tied to a flap, forming a right angle with the table. This position, which rarely is used for diagnostic purposes, is of the higliest value in operations in the depth of the pelvis. In protracted operations in this position the pelvic organs become comparatively anemic, and when the patient is brought back to the horizontal position, a con- ' This position is in this country often called Trendelenburg's (tlie accent is on the first syllable — Tren'dei-en-burg). In Germany, where it was invented, it is known as Berkenhochlage. Trendelenburg has contributed much to tiie populariza- tion of the position ; but years before, it was used and described by Bardenheuer ( Drainirunf) der Peritonealhohle, Stuttgart, 1881, p. 276), and is said to have been used still earlier by Billroth in Vienna. EXAMINATION IN GENERAL. 141 gestion takes place, wliich may cause hemorrhage corresponding to what takes place after the artificial anemia brought on by Esmarch's method. It is, therefore, a wise precaution to raise Fig. 112. Klcvatod-pclvis position. the foot of the bed during the first two or throe hours after the operation.^ The ventral position is needed when we want to use percussion on the lumbar region ; e. g. in a case of supposed floating kidney. The patient lies stretched out on her front surface and one side of her face, and the physician stands at her side. When the patient is placed in the proper position, we proceed to e.xamine her, and, in order not to overlook anything, we will consider separately the examination of the 2)clvis, the examination of the abdo- men, and other diagnostic means. II. The Examination of the Pelvis. — The means employed are inspection ; digital examination through the vagina, the rectum, and the bladder; combined examination; artificial prolapse of the utenis ; specula; the uterine sound ; the probe; and dilatation of the cervical canal. A. Inspection is peribrmed while the })atient is in the dorsal posi- tion. Having in mind the normal anatomy of the external genitals (pj). 35 to 47), we })ay attention to every deviation from the stiintlanl. 15. Digital Krarninfdion. — The fingers, esj)ecially the two index- fingers, are instriiments of exj)loration of the very greatest value. The touch can to a great extent replace vision, and is soiiictinies superior to it — e. g. in judging of the extent of a cervical laceration — but a good deal of practice is needed before the limit of all (he ))n.-si- ' il. C. C'oe, New York I'didlnic, Sept., ISUIJ. 142 DISEASES OF WOMEN. bilities of this sense are reached. Great care should be taken to cul- tivate both index-fingers, as it is an immense advantage to feel equally well with both. By being able to do so, we can often avoid changing the position in which we find the jiatient, which in private practice often is preferable. Besides, the patient being in the dorsal position, we feel best with the homonymous finger — i. e. we feel what is in the right side of the pelvis best with the right index-finger, and what Ls in the left side, with the left index-finger. The fingers and the hand are used in several ways. The index- finger may be introduced into the vagina, the rectum, or the bladder; the fingers of the other hand are used on the abdomen ; and dif- erent forms of these explorations may be combined. Cleanliness. — It goes without saying that the physician shall have clean hands and short nails, kept clean with brush and steel, but strict asepsis, which is the absolute duty of the obstetrician and of the gynecologist in performing operations, is not required for common gynecological examinations. Lubricants. — Before the finger is introduced into the vagina it ought to be made slippery with some suitable lubricant, such as vaseline, olive oil, or a solution of soap. In rectal examinations it is a good plan first to fill the space under the nail by running it over a cake of soap. For vesical examination only the mildest lubricants, such as vaseline or olive oil, should be used. Vaginal Examination. — The patient is in the dorsal position. The physician stands in front of her, observing her face, which will often give valuable information in regard to tenderness, pain, or sexual excitement. If the vulva does not gape, the labia majora are sepa- rated M'ith the thumb and index-finger of one hand, while the index- finger of the other is introduced. As a rule, only the index-finger is used in the vagina. It is stretched, the last three fingers are bent flat in a<2:ainst the hand, so that one riffht ang-le is formed at the joints between the metacarpus and the first phalanges, and another between the first and second row of phalanges The index-finger, again, forms a right angle with the first phalanx of the middle finger, and the thumb is either extended so as to form a right angle M"ith the metacarpal bone of the index-finger, or bent against the second phalanx of the middle finger (Fig. 113). In exceptional cases, and in women with large vaginal entrances, both the index and the middle finger may be used simultaneously in the vagina, which allows us to ])enetrate fully an inch deeper, but causes some pain. In entering it is well first to ascertain the condition of the vaginal entrance, especially tlie perineal body. In proceeding we notice the condition of the walls of the vagina in regard to smooth- ness, rugosities, hardness, adhesions, cysts, etc. Next, we j)lace the tip of the finger on the os, and examine its size, shape, and direction. EXAMINATION IN GENERAL. 143 We notice the length, thickness, shape, and consistency of the cervical portion. The remainder of the vaginal examination is done much better by the bimanual method than by the unassisted finger. For this purpose the physician places the four fingei-s of the other hand on the hypogastric region — in the middle for the examination of the uterus, over the right and left iliac fossa for that of the appendages, the broad ligaments, the parametria, etc. — and presses well down, so as to bring the organs within easier reach of the finger in the vagina, and at the same time palpate them from above. The index-finger is placed against the anterior part of the vaginal roof, while the fingers of the other hand rest on the fundus. Thus we easily sweep over the anterior surface of the uterus. Next we place the inside finger against the posterior part of the roof of the vagina, the so-called cul-de-sac, and push the fingers of the other hand with the tips turned downward and the pulp forward, far down behind the uterus, which in lean women allows us to examine the whole pos- terior surface of that organ. After that we place the inside finger on the left lateral part of the vaginal roof, and the outside fingers over the corresponding iliac fossa. By pushing the inside finger well Fig. 113. Combined E.xamiimtion (Schroeder). upward and backward, a little otit.'^ide of the edge of the uterus, we are sometimes eual)l(Hl to feci the ovaries, the tul)es, the sacro-uterine ligaments, cy.sts of the broad ligaments, exudations, infiltrations, pel- vic abscesses, etc. Finally, we examine the right side of the pelvis in the same way. 144 DISEASES OF WOMEN. Rectal examination is best performed with the patient in Sims's position. We look for hemorrhoidal tumors, fissures, mucous patches, chancroids, etc. The physician stands behind the patient, and intro- duces his right index-finger as far as it goes, which is to the so-called third sphincter (p. 90), and in so doing he pays attention to tumors, ulcers, or strictures of the intestine itself, and to the condition of the genitals in front, and the sacro-uterine liagments laterally. Some- times the uterine appendages are felt better from the rectum than from the vagina. In cases of abdominal tumors this examination ought never to be neglected, as valuable information is often gained thereby which cannot be obtained in any other way. In virgins it may sometimes replace vaginal examination. But in most cases the diagnosis can be made by the other modes of examination, and as this one is particularly disagreeable to physician and patient, and much more jiainful than a vaginal examination in a woman who has had sexual intercourse, it is by no means used in every case. In regard to its combination with artificial prolapse of uterus, see below. In children, rectal examination, combined with abdominal, is of great value, but demands anesthesia. Xot only the pelvis, but nearly the whole abdomen may be explored in this way. Vesical Examination. — The urethra can easily be dilated by means of a set of seven coniform tubes with obturators (Fig. 114) vary- ing from 1^ to 2f inches in circumference, until the index-finger can be introduced into the interior of the bladder. This procedure permits the palpation of tumors in the bladder itself or between the uterus and the bladder, facilitates the introduction of instruments into the ureters, and may decide about the presence or absence of the internal genitals in a case of atresia of the vagina. The patient is, of course, anesthetized, and occupies the dorsal position. The method is valuable, but, as sometimes it has led to incurable incontinence,^ it ought only to be risked in cases in which the information sought is of great importance and cannot be obtained in any other way.^ As a rule, we can reach our goal by means of a catheter in the bladder and a finger in the vagina or the rectum, or both. Combined Examination. — Sometimes it is an advantage to combine several of the above-mentioned methods. Thus, a good mode of examining the perineal body is to introduce the index-finger into the rectum and the thumb into the vagina simultaneously. In other cases tin middle finger is introduced into the intestine, the index- finger into tiie vagina, while the four fingers of the other hand palpate through the abdominal wall. ' T. A. Emmet, Principles and Practice of Gijnecolocjy, 2d ed , 1880, p. 732. ^ I have, for instance, done it successfully in an old lady with a large cancer- ous mass situated on the base of the bladder, and precluding incision from the vagina. EXAMINATION IN GENERAL. 145 C. Artificial Prolapse of the Uterus, by which this organ is pulled down by means of a volsella to the entrance of the vagina, is much practiced in Germany, and has some advocates. in this country.^ By handing the forceps to an assistant, introducing one or two fingers into the rectum, and depressing the abdominal wall with the other hand, if the uterus is of normal size, its whole posterior wall up to the fundus may be palpated, and likewise the broad ligaments, tubes, ovaries, and the pedicle of an ovarian tumor. The method is not without danger, as it is liable to set up an acute peritonitis or cellulitis where there are remnants of old similar aifections, and even endanger the integrity of the tubes or large veins in the broad ligaments if, perhaps, they are bound by old adhesions which es- cape our attention. It is better not to be too zealous a diagnostician Fig. 114. Gustav Simons's Urethral Specula: B represents the largest size; A is one number smaller (Two-thirds natural size). than to risk making the condition of the patient worse in trying to determine its preci.se character.^ D. Specula. — In order to see the deeper parts of the canals leading to the pelvic org-ans we have iii.struments called "specula," which at the same time an; of great importance for treatment, since they render it p<^)ssible to make applications to, or perform o})erati()iis on, tiie ' Howard Kellv has construrted a sj)efial kind of liook for tlie purpose (Amrr. Jimr. ObMct., \m\, vol. xxiv. No. 2, j). 141 i. * For details tlie remler is referred to a pai)er liy II. ('. Coe, Mid. Ilcrord, Autr. '•*, 1890, vol. xxxviii. No, 6, p. 141. 10 146 DISEASES OF WOMEN. parts exposed. We liave vaginal, cervical, rectal, urethral, vesical specula, and the (jalvanic ci/stoscope. Vaginal SpecuUi. — Of these there are a great variety, but virtually they may be reducal to three types : the tubulifoiin, the pluHvalve, and the univalve specula. Of the tuhuliform specula, Fergiisson's is the one most in use (Fig. 115). It is made of glass, covered with black varnish on the outside. Fig. 115. Fergusson's Vaginal Speculum. A layer of tin-foil is inserted between the glass and the varnish. The proximal end has a flange which serves as handle and as check in introducing the instrument. It is mostly used with the patient on her back. The labia majora are separated, the most prominent point of the end is introduced through the vagina, pressing on the perineal body. The anterior and posterior walls of the vagina should be seen all the time touching each other in a transverse line until the vaginal portion with the os takes their place. This speculum gives excellent light, but is inferior in all other respects : it pushes the uterus away ; it spreads out a torn cervix, so that the tear may be overlooked;^ it cannot be used for the inspection of the fornix of the vagina, which is often of as much interest to see as the os ; it does not allow us to introduce the sound through it, unless we take a very wide and short one, which, again, can only be used where the vagina is exceptionally wide, and which causes pain ; and it is hard to clean. Of the plurivalve spwula, some modification of Cusco's bivalve — e. g. Brewer's speculum (Fig. 116) — is most generally useful. A good instrument of this class should have few blades, for the more blades the more folds of the vagina will get in between them and obstruct the view. It should have a rounded end, so as to be intro- duced M'ithout causing pain. It should have a very wide opening, in order to admit much light, and at the same time be narrow at the vaginal entrance, so as not to cause too much distension and j)ain there. The blades should be of the same length : if the anterior is ' The almost exclusive use of this speculum in Enfrliind accounts in a great meas- ure for the tiirdiness with which Emmet's laceration and its cure by operation were recognized there. EXAMINATION IN GENERAL. 147 half an inch shorter than the posterior, as in some instruments of this kind, the os cannot be seen if the uterus is auteverted. Fio. 116. Brewer's Speculum : A, open ; B, closed ; C, handles ; 1), set-screw. The bivalve specuhim is used to greatest advantage in the dorsal position. Before introducing it tlie physician ascertsiins by touch the position of the os, and dir<!cts the instrument, closed, in that direction to its full length or till he reaches the vaginal portion. Then the branches arc separated by pressing on the handle (C), turning ^he screw, and the instrument pushed a little farther in, so as to reach tlie fornix of the vagina. The univalve or tSinis speculum (Fig. 117) is the only one that Fk;. 117. Slms's Speciilum. shows the uterus and the anterior wall of the vagina in their normal position and relation, since all it (hx'S is to pull back the |K!rineal bcxly and the posterior vaginal wall. It covers a smaller part of the vagina than the other two. Jt alone allows us to combine touch with sight, 148 DISEASES OF WOMEN. and it is indispensable in the performance of operations for conditions which before its invention were incurable. Sims's speculum is most frequently used with the patient in the genu-pectoral or in Sims's position, but it is often also used either on the posterior or on the anterior wall of the vagina, or on both at the siime time, in the dorsal decubitus. Generally, two Sims's specula, of diiferent sizes, are combined in one instrument, but for use on the posterior wall of the vagina in the dorsal decubitus a single one, with a suitable handle, is required. (See Vaginal Hysterectomy,) Sims's own way of introducing his speculum was to hold the han- dle with the left hand and use the thumb and index-finger of the right hand as a guide (Fig. 118); and where there are folds or other obstacles in the way, this is the best way of introducing it, the end of the finger being used to push the obstacles aside and place the end Fig. 118. Introduction of Sims's Speculum. of the speculum behind the cervix. But in ordinary cases the physi- cian seizes the handle with the right hand, placing the tip of the index- finger at the base of the blade to be introduced. He stands behind the patient, separates the labia, holds the speculum so that its plane forms an angle of 45° with the top of the table, pushes it slowly in along the posterior wall to the posterior cul-de-sac, and brings it then over on the right side of the coccyx. After that he performs a move- ment in the direction of part of a circle, by which the perineal body and the posterior vaginal wall are pulled back. In so doing he gives the air free access to the vagina, and the viscera, falling by their own w^eight, up against the anterior abdominal wall and the diaphragm, the air distends the vagina so that it becomes more like a hollow globe than a cylinder — the so-called haUooning. This ballooning may, however, occur under circumstances in which air-pressure can- not be the moving principle. I have often felt it in examining EXAMINATION IN GENERAL. 149 patients in the dorsal position, and I have felt an exactly similar dis- tension of the rectum when the examining finger excluded all entrance of air. In such cases the ballooning is, in my opinion due to con- traction of muscles extending from the Avail of the cavity in question to fixed points in the surroundings (p. 43 and Fig. 55, p. 60). If the OS and posterior lip do not present themselves, they must be brought forward in some way, either by pulling on the anterior lip with a tenaculum, or, since this causes some pain, preferably by intro- ducing the end of a sound into the os, if that can be reached, or by using a depressor on the anterior wall of the vagina, such as Sims' s, consisting of a flexible metal rod with a loop at each end (Fig. 119), Fig. 119. Sims's Double Depressor. or, better, J. B. Himter^s, a silver-plated copper rod ending in a S})oon at each end (Fig. 120;', cr my ov.n, which will presently be described. Fig. 120. Hunter's Depressor. ModificMions of Sims's Speculum. — Jhmde's speculum (Fig. 121) is a Sims's speculum to whicli is added a flange that holds the u])per nates out of the way. Jfiibhard W. M'dclieirs speculum, (Fig. 122) is a single Sims's sj)eculum with jMundc's flange and wings, which give a good iiold for the index- and middle fingers. Self-hold i)ir/ Sims Sjtecula. — If one holds one of these flaiig(Ml specula or a common Sims speculum in his left hand, re(|uesting tli(! patient to lift the ni)j)ei* nates herself, and he holds the depressor in the right hand, Ik; can see well enough, but no hand is left for treatment. Tin; consequence is, that he nnist have an assistant. The ])resenee of a third ))erson, especially a female mu'se, ofl'ei-s many advantages, but not overvbody who wants to ns(> Sims's sjK'culum, has suflieient gvnee(»logieal jtraetice to make it pay to keep one for the j)iu*j)osc. A luunber of instnnnents have, tlieref"oi-e, l)e<Mi con- structed with the aim of making the a.ssistant superiluous ])y render- 150 DISEASES OF WOMEN. ing Sims's speculum self-holdiug. The best instrument of this class is, in my opinion, that of the late Dr. Ehrich of Baltimore (Fig. 123). It is true, no in- strument can surpass the Fig- 122. hand of an exjierienced nui*se, but to hold Sims's speculum for any length of time is very trying, and Eh rich's speculum is infi- nitely more useful than the hand of an assistant who has not had great practice in holding it. It is a sin- gle Sims's speculum with Fig. 121. Mundt>'s Speculum. H. W. Mitchell's Speculum. flanges for both nates, fastened to a curved metal rod articulating with a plate which rests on the sacrum, and is kept in place by means of a band going over the patient's left shoulder. If sometimes a little help is needed, it may be rendered by any by- stander, since all that is required is to pull the curved rod a little backward. All these self-holding apparatus are, however, bulky, expensive, apt to frighten the patient, and take much more time to apply than a common Sims speculum. In order to have all the advantages of EXAMINATION IN GENERAL. 151 the latter without being obliged to have an assistant for a mere appli- cation, curetting, and similar manipulations, I Fig. 123.^ have had a vaginal de- preasor constructed which is held with the same hand as the speculum (Fig. 124).2 The han- dle, seen to the left, is held against the middle part of a double Sims speculum. The other end is placed in front of the cervical portion. The bow in the middle cor- responds to the vulva and leaves the vagina unencumbered. It is on purpose that there is no connection between the depressor and speculum. A slight pressure with the thumb allows the physician to bring the depressor in whatever Ehrich's speculum. Fig. 124. (iarrigues' Vuginal Depressor. ' This {\frine represents tlie speeulnm so modified lliat flie vnf^iiKil l)lade is divided into two lateral liaives, wliicli can he se|)arated and M])i)roxiinat('d l>y means of a s<'re\v. It lias also a depressor for tin- anterior wall wJiieli is fastened to tiie nppev flange. This depressor prevents one from pnlling tiie uterus down and lias not ap- peared praetieal to me. ^ II. .J. (iiirrignes, "A Vaginal Depressor," Med. lironl, 1881, vol. xx. p. (IDS. 152 DISEASES OF WOMEN. direction may be needed for the inspection of any irregularly placed OS, and the instrument is easy to cleanse. All specula are smeared with a similar lubricant as the one used for the examining finger (p. 142). When the cervix is exposed it is in most cases necessary to wipe away the mucus that covers it, which Fig. 125. Bozeman's Dressing Forceps. is done by means of a long pair of dressing-forceps (Fig. 125) holding a pledget of absorbent cotton dipped in some antise])tic fluid. Cervical specula (Fig. 126) are conical or cylindrical tubes on a long shaft which are pushed into the cervical canal. They are less used for seeing than for preventing any application destined for the Fig. 126. Burrage's Cervical Speculum : a, tube; b, handle ; c, movable clasp, preventing ends of wire composing handle from slipping out of d, small tube at right angles to main tube ; e, smaller cervical tube to replace a; /, obturator iitting the two tubes. cavity of the uterus from being rubbed off on the cervical wall, and for packing the uterine cavity with gauze. Rectal specula cause much ])ain, and should therefore not be used unless imperatively needed for diagnosis or treatment. Often a Sims or bivalve vaginal speculum may be used instead of a special rectal speculum. AsJdon's rectal S])eculum is constructed on the same prin- ciples as Fergusson's vaginal, but with a closed round end and fenestra on the side (Fig. 127). Kelsey's bivalve rectal speculum is the best I know of (Fig. 128). Uretln-al specula are sometimes needed. Jackson''s (Fig. 129) con- sists of a tapering glass tube, closed at one end and provided with a EXAMINATION IN GENERAL. Fig. 127. 153 Ashton's Rectal Speculum. flange at the other, and having a fenestra on one side. It is conve- nient to have a set of three such tubes, but the one two and a half Fig. 128. Kelsey's Rectal Speculum. inches long and half an inch in outside diameter will be suitable for most cases.' Skene has adapted Folsom's nasal speculum to the Fig. 129. Jackson's Uretliral Speculum. urethra (Fig. 130). It consists essentially of two oblong rings of ' A. Reeves Jac-k.son, Amer. Gyn. Trans., 1877, vol. ii. p. oT-'i. 154 DISEASES OF WOMEN. Fig. 130. metal wire separated by sprinji^ force, and capable of being kept at the desired distance by means of a set- screw. For the inspection of the deeper parts of the urethra, a reflected light is necessary. Vesical specula Mill be described below in speaking of Examination of the Bladder- and Ureters. E. The Uterine Sound (Fig. 131) consists of a somewhat flexible silver-plated copper rod with a flat handle. At the end it has a little knob, at 2^ inches a small protuberance with a notch marking the normal depth of the ute- rine cavity, and other notches with figures by which the depth to which the sound enters is easily read off. The sound is a very useful, aud, when properly used, harmless, instrument, but in handling it we must never forget that it is a metal Fro. 131. Folsom - Skene's Urethral Speculum. Simpson's Uterine Sound. rod hard enough to perforate the wall of the womb, and that it is introduced into a cavity from which absorption easily takes place. The greatest gentleness of manipulation and antiseptic pi'ccautions are therefore indicated. As to the latter, it is hardly feasible to carry them out strictly in every case, but we ought at least to disinfect the sound, and, if there is any bad discharge in the vagina, it ought to be removed by an injection and swabbing before the sound is intro- duced. By the use of the sound ])athogenic germs may be brought from the vagina, where they abound, or from the cervix, where they often are found, into the cavity of the corpus, which never is their normal habitat. But in order that the reader may not form an exag- gerated idea of the danger of this mode of infection, I may state that with a very free use of the sound, and that for many years, before I used any antiseptic precautions, I have only four times seen inflam- mation occur — once acute metritis, and in the other cases exudative peritonitis. The sound is commonly u.sed in the dorsal or in the lateral posi- tion, with or without speculum. As a rule, I think the intro<luction in the left lateral position without speculum is the best. The sound EXAMINATION IN GENERAL. 155 should never be used before the position and the shape of the uterus have been ascertained by palpation, and if there is any marked devia- tion from the normal direction of the uterine canal, the sound should be curved so as to correspond to it, apart from the slight curve which always is given to the last 2J inches in order to introduce it more easily into the canal, which forms an angle with the vagina (p. 54). The tip of the left index-finger is applied to the os; the lubricated or wet sound, held between the thumb and index-finger of the right hand, is slid along the palmar surface of the finger till it reaches the os; then the finger is placed on the front or back of the uterus and used to tilt that organ in the proper direction in order to facilitate the intro<luction of the sound. A peculiar snap is felt when the sound passes the internal os. Often it is caught in the folds of the cervix (p. 50) ; then it must be pulled a little back, and turned in another direction. When once it has passed the internal os, the handle is pushed well back until the stem points in the direction of the umbili- cus. As soon as the resistance of the fundus is felt we desist from further pushing. In cases of anteflexion the introduction is often greatly facilitated by introducing the sound with the concavity turned backward as far as it goes, and then reversing it; or by giving it a sharp curve near the end like a prostate catheter. In order to measure the depth of the uterus, the handle of the sound is held with the left thumb and index-finger, the tip of the right index-finger is applied to the sound just below the anterior lip, the sound is grasped with the right hand and withdrawn, and finally the distance from the tip of the finger to the end of the sound is read off. Often the sound is used in connection with a finger in the vagina or in the rectum, or fingers pressed down behind the symphysis in order to locate tumors in the wall or in the neighborhood of the uterus; and sometimes it is used for moving the uterus in difierent directions, and thus ascertaining; the relation of this ormui to tumors in its vicinity. F. The Probe. — The ])r(^be is a much thinner, very flexible rod with handle, used exclusively for (exploring the inside of the uterine cavity. It is made of metal, hard rul)ber, or whalebone. G. The C'lirrlfe. — The cui-ette is an instrument used for scraping something off the inside of th(» uterus or other cavities. It is mostly used as a therapeutic agent, but sometimes it is employiMl in the ser- vice of diagnosis in order to obtain a specimen for nii('roseo])ieal examination. The chief curettes are Sims's (V\^. MVI) and Simon's (Fig. ]'>')) sharp and stiff, and Thomas's dull and flexible curettes (Fig. l.'>4). In the choice of a '^riiom.'is dull-wire ciu'ctte the j)nr- ehaser should take good care not to buy one that is so flexil)l<' that 156 DISEASES OF WOMEN. it bends while being used. It should only be so flexible that it can be bent to adapt itself to the shape of the uterus in which it is going to be used. Simon's seems to me the best instrument for the cervix, and of late years I use it also exclusively in the body of the uterus. In curetting great care should be taken to disinfect the instrument, the vagina, and the interior of the womb both before and after operating. Fig. 132. Sims's Sharp Curette. H. Dilatation. — Sometimes it becomes necessary for diagnostic purposes to dilate the cervical canal suificiently to introduce the curette or the finger. This may be done slowly by means of teiits, or rapidly by means of cones or diverging rods working on the principle of a glove-stretcher. Except during or shortly after pregnancy, it is hardly feasible to dilate the cervical canal by rapid dilatation to such an extent that Fig. 133. Simon's Sharp Curette. the finger can be introduced. If this is necessary, laminaria tents should be used for from twelve to twenty-four hours. They not only dilate the cervix, but soften it so much that rapid dilatation there- after may be able to accomplish what it could not before. Tents are cones made of substances that swell by ab.sorption of fluid, especially sponges, sea-tangle (laminaria), tupelo root, and slippery- FiG. 134. Thomas's Dull Wire Curette. elm bark. It is next to impossible to get these tents disinfected, and they are therefore dangerous, and ought only to be used in very exceptional ca.ses, especially for tiie dilatation of fistulous tracts. Laminaria tents are disinfected by placing them for one or two minutes in boiling antiseptic fluid. This makes them, at the same time, so soft that they can be curved to fit a bent cervical canal, and, on being placed in cold fluid, they become immediately hard again. EXAMINATION IN GENERAL. 157 Still, they should never be brought in contact with a fresh wound. If the sound is used and a drop of blood appears, the introduction of the tent should be postponed for twenty-four hours. Such tents may be kept in a solution of bichloride of mercury in absolute Fig. 135. Barnes's Tent-Tntrorliiper. A tent is seen fitted to the end ready for introduction. Whien it has been placed, the stylet on which it is mounted is withdrawn tlirough the tubp, with which the tent is steadied till the stylet is quite free from the tent. alcohol, 1 to 100. Just before insertino: them they arc dipped in corrosive sublimate glycerin (1 to 1000). The patient mu.st keep absolutely quiet for a few hours imtil the tent is sufficiently swollen to be retained. The labor-like pain produced by the swelling Fig. 136. Hanks's Uterine Dilator. may be relieved by applying a hot-water bag, cloths wrung out of hot water, or a hot poultice to the alxlomen. If needed, four or more tents may be introduced, one after the other, changing Fi(i. 137 Garrigues' Uterine Dilator. them twice in twenty-four hours, and wasliing out the uterus at the same time.' The tent is introduced with a pair of dressing forceps or Jiarnes's tent-carrier (Fig. 1.35). For diagnostic purposes, and as ])art of treatment, dilatation is much safer when jx'rformcd rapidly. For the lower degrees of ' ThLs is the method of 15. S. Schultze, ChilmMut fiir (hjiuikoL, 1S7S, vol. ii. p. 150. 158 DISEASES OF WOMEN. dilatation a few of Hanks's coniform hard-rubber dilators (Fig. 136), a moditieation of Hegar's, are very serviceable. Where there is great narrowness of the os, it may, however, become necessary first to make a small incision in its edge. For the next degree of dila- tation, up to Ij inches, a strong instrument of the diverging kind is required. I have had one made which I think unites the best features of the different instruments of this class (Fig. 137). It lias EUinger's parallelogram ; only one handle, in order not to Fig. 138. Goelet's fourbladed dilator. obscure light ; fine ridges on the lower part of the branches, in order to prevent the instrument from slipping without bruising the uterus too much ; curved branches, since these are more easily introduced than the straight, and the uteri upon which they are used are commonly ante- or retroflexed. A strong and even dilatation is obtained by means of Goelet's four-bladed dilator (Fig. 138). For the very highest degrees of dilatation — which, however, scarcely are needed for mere diagnosis — the writer has had a series Fig. 139. Olive-shaped dilators. of ten hard-rubber olives made, which can be screwed on a metal shaft (Fig. 1 39). One of the balls .serves as a handle, while anotlier is slowly pressed through the cervix. They correspond to num- bers 22 to 45 of the American scale (33 to 67.5 millimeters in circumference). EXAMINATION IN GENERAL. 159 Since dilatation cannot be resorted to without bruising and tearing the tissues to some extent, it goes without saying that the rules of antiseptic surgery must be scrupulously observed. Dilatation has been carried to such an extent as to make the whole cavity of the uterus visible up to the fundus (Yulliet's method ^). This is obtained by introducing small bulbs of absorbent cotton im- pregnated with iodoform ether (1 part iodoform to from 10 to 30 ether), dried, and tied to strings. These balls are carried with dressing- forceps and sound right up to the fundus. Local anesthesia is produced with pledgets dipped in cocaine solution. The patient is in the genu-pectoral posture. W the cervical canal is too narrow, it is fii*st dilated by means of the above-mentioned dilators. The tam- pons are left in for forty-eight hours. In order to dilate the cervix and lower uterine segment, it is sometimes necessary to combine the use of these cotton balls with a bundle of laminaria tents, the cotton ball being pnshed up in the centre of the bundle as far as the middle of the cervical canal, so as to form a cone which is left in from ten to fifteen hours. After the dilatation of the cervix has been obtained in tiiis way, only cotton balls are used and the packing renewed. Occasionally this method might prove valuable both tor diagnostic purposes and for the re- moval of tumors from the cavity of the body of the Momb. The cervix having been dilated, the interior of the uterus may also be inspected by means of Goelet's uterine sjx'culum, an instru- ment similar to Kelly's bladder-speculum (Fig. 141). I. Examination of Virgins. — The vaginal examination ought to be avoided as much as possible in virgins. In cases where the symptoms are not grave, such as leucori'hea, menstrual disturbances, backache, etc., it is better to desist from an attempt at an exact diagnosis, and first try the effect of medical treatment. Some information may be gained by the rectal exploration. If, however, the symptoms point toward more serious trouble, a vaginal examination becomes imperative, but ought only to i)e undertaken with great care and deliberation. Un- fortunately, many girls an; easy enough to examine, but in a really intact girl the introduction of the finger meets Avith considerable resistance, and the sharp edge of the hymen is felt like a fine steel cord on the l)ulp of the finger. With the excej)tion of a few urgent cases, in which it is necessary for treatment's sake to make a spe(Hly diagnosis, it is better first to prepare the hymen by the introduction twice daily of a small tamj)on of absorbent cotton soaked in glycerin. \\y gradually increasing the size of the tampon at every change the parts will in a few days be sufficnentiy softened and dilated to allow the index-finger to ])ass. It should be carefully lubricated all over and intr(xlu(;ed very slowly, in order to avoid causing unnecessary pain ' ViiUiet et Liitaiul, Lt;(;ons de Gynccologie operafoire, Paris, 1890, p. 75. 160 DISEASES OF WOMEN. and rupturing the hymen. When once the finger has passed, a small- sized speculum may be used if necessary. III. The Examination of the Abdomen. — The patient occupies the doi*sal position ; the physician stands at her right side. The diag- nostic resources at his command are inspection, palpation, 'percussion, auscultation, mensuration, injection of water into the intestine, and production of carbonic acid in the stomach. A. Inspection. — The practiced eye can frequently, at the first glance, distinguish the more pointed prominence caused by a tumor or preg- nancy from the flat enlargement due to an accumulation of free fluid in the abdominal cavity or to hyperplasia of adipose tissue. We look for changes in pigmentation {linea fusca), subepidermal tears in the skin {strioe albicantes), and the protrusion of the navel. B. Palpation is superficial or deep. By folding the abdominal wall we judge of its thickness and mobility. By slight pressure we some- times get a crackling sensation due to fresh adhesions. By deep pressure we try to gain as much information as possible about the contents of the abdomen. We examine if there is any abnormal ten- derness anywhere. We feel for hard masses. If we find any, we try their mobility. If it is the uterus that is enlarged and has risen up into the abdomen, the best way of testing its mobility is to place the index-finger on the os and move the fundus from side to side, when the cervix will be felt to move in the opposite direction. If the mass contracts while being palpated, we know then that it is the gravid uterus. If a patient make a deep inspiration, a tumor of the liver will ascend under the following expiration while all other tumors may be kept down with the hands.^ In palpating tumors the bimanual examination (Fig. 113, p. 143) is likewise often used. The physician stands then between the legs of the patient. Often an assistant is "needed to lift the tumor or move it from side to side. By placing the fingers of one hand lightly in one place and pressing on another with those of the other liand, we ascertain if there is diXxy fluctuation — a sign which denotes the presence of a fluid. In a case of pregnancy we may be able to recognize certain parts of the fetus. C Percussion. — By means of percussion we find out whether we have the normal tympanitic sound of the intestine containing gas, or a dull or flat sound characteristic of a solid mass or a fluid. We note very carefully the limits of the dull area, by which we get valuable information in regard to the starting-point of the tumor. If it is a fluid, we make the patient alternately lie on the back and on either side while we use percussion. If the fluid sinks down, leaving a ^ Naunyn, reported by Minkowski, Centrcdblalt fiir Gyndkologie, 1888, vol. xii. p. 790. EXAMINATION IN GENERAL. 161 tympanitic area above, we conclude that the fluid moves freely in the abdomen (ascites), whereas it cannot change position if enclosed in a cyst. D. Auscultation often gives information of the very greatest im- portance. Whenever we have to examine an enlarged abdomen we ought always to bear pregnancy, normal or extra-uterine, in mind as the key to the whole condition or as a complication. We listen, therefore, for the double sound characteristic of the fetal heart, for the sound caused by fetal movements, and for the blowing sound {uterine souffie) formed in the large vessels running along the sides of the womb. The latter may, however, also be heard in fibro-cystic tumors of the uterus. The bruit produced in an aneurism of the abdominal aorta has a different character, and is accompanied by other characteristic signs. E. 3Ieusu7-ation. — The measures are taken with a tape-measure in the dorsal position. This method is especially used in order to form an idea of the size of a tumor, and gives sometimes information in regard to its starting-point. The measures usually taken are the girth at the level of the umbilicus, the girth at the most prominent point of the swelling, the distance from the umbilicus to the symphy- sis, the ensiform process, and the anterior superior spine of the ilium. F. Development of gas in the stomach and injection of trater into the intestine have recently been recommended for diagnostic purposes. The stomach is expanded by giving bicarbonate of sodium and tar- taric acid, which together develop carbonic acid. Later the stomach is evacuated by introducing a soft- rubber oesophageal sound, and tepid water is injected into the intestine by means of a fountain syringe. In this way a tumor is displaced in the direction from which it has started.' G. Charts. — It saves much time and contributes to a precise diag- nosis to use printed charts representing tlie outline of the abdomen and pelvis in front and side view, and mark on them the location of any swelling found by examination.^ IV. Other Means of Investigation Common for Pelvic and Abdom- inal Diseases. — Such are exploratory aspiration, cvploratonj incision, urinary awdysis, microscopic e.vanunation, chemical examination, ex- amination under anesthesia, and e.vamin<dion of the ureters.^ A. IJrimtry analysis ought to be made in every case before an ojie- ration is uiidertnUen, and even before the patient is subjected to the influence of anesthetics, as the result of the analysis may decide which anesthetic should be preferred (see Anesthesia). But even in minor ' Naunvn, CrnlmlhlnU f. Cyn., ]8s,-<, vol. xii. ]). 7!)0. ing Co, Rubber stamps for recording' cases are manufactured by tlie I'.arton Manufacfi ., No. I^.'iS I'.roadwav, New York. II 162 DISEASES OF WOMEN. gynecology the examination of the urine often gives vahiable hints as CO diagnosis or treatment. The urine should be examined chemically and microscopically. B. Catheterization of Bladder. — In most cases the patient may pass her urine herself and send it for examination, but if there is any complaint referable to the bladder, the urine should be drawn with the catheter. To do this under the clothes is easy enough, but entirely antiquated. We know that by introducing mucus from the vagina or vulva into the bladder we may set up cystitis. The meatus urin- arius should, therefore, be exposed, the patient being either in the dorsal or left-lateral position. The vulva is opened with the fingers of the left hand, and the vestibule wiped with a pledget of absorbent cotton wrung out of an antiseptic solution. Next the disinfected catheter, held with the thumb and index-finger of the right hand, is introduced. A metallic catheter is preferable, as it is easier to keep clean, and in many examinations a stiff rod is needed. It ought to be lubricated by immersion in water containing 1 per cent, of lysol, creolin, or carbolic acid, and introduced in a curve hugging the symphysis pubis. C Microscopical examination is of great diagnostic value for the gynecologist. It is applied to the urine, pathological fluids obtained by aspiration, and solid bodies removed with the curette or cutting instruments. In examining urine special attention is paid to the presence of epithelial cells from the different parts of the urinary tract and the external genitals (Fig. 140), to casts characteristic of nephritis, and to the different crystals abnormally seen in urine.^ As a sample of fluid let us take that from an ecchinococcus. A, single booklet or a particle of the structureless stratified cuticula, revealed by the microscope, settles the diagnosis. A piece of tissue scraped off with a curette or cut off with scissors may tell us if it comes from a part affected with carcinoma. D. Chemical Examination. — Chemical reactions are esj^ecially used to reveal the presence of sugar, albumin, or gall in urine or other fluids. E. Examination of the Bladder and the Ureters. — The size, sensi- tiveness, and elasticity of the bladder can be tested with a metal catheter. Howard Kelly's bladder-speculum^ necessitates previous dilatation of the urethra, but offers the advantage that the inside of the bladder can not only be seen, but can be treated locally on any limited area. ' For details the reader is referred to the work of Charles Heitzmann, Microsmpic Morpholocjy of the Animal Body in Health and Disease, New York, 1883, with its excellent illustrations. '^ This method and the instruments used have been claimed by Pawlik as his ( Amer. Jour. Obst., March, 1896, vol. xxxiii. pp. 387-405, and August, 1896, vol. xxxiv. pp. 253-261). EXAMINATION IN GENERAL. 163 The patient is at first placed in the common dorsal position, and the bladder emptied with a catheter. By means of a coniform calibrator Fig. 140. Epithelinl Cells found in Urine X '''W (C. Ileiuniunn): B, from bladder, superficial layer; HM, from middle layers of bladder; III), from deepest layer of liladder; P, from tlie prostate; K, from the ejaculatory duet; V, from superficial layer of vagina; \'M, from middle layers of va^'ina ; VI), from deei>est layer of vagina : <'. from the outer surface of the cervix uteri ; II, from the cavity of the uterus; J'K, from pelvis of kidney ; KC, from the convoluted tulxis of the kidney ; KS, from tlie struiglit tuljcs of the kidney. introduced into the urethra as far as it will readily go, tlu^ measure of the meatus uriiiarius is taken. A dilator (Fig. HTj) of the same size is inserted instead of the calibrator, and gradually rcplacetl by thicker ones. The average female urethra can easily l)e dilated up to 164 DISEASES OF WOMEN. 12 millimeters in diameter with only a slight external rupture. As Fig. 141. Method of Holding the Speculum during Introduction, the thumb pressing upon the handle of the obturator (Kelly). soon as a dilatation of 12 to 15 millimeters is reached, a speculum (Fig. 141) of the same diameter as the last dilator is introduced and its obturator removed. The hips of the patient are now elevated on cushions 8 to 16 inches above the table. The examiner puts on u head-mirror in a dark room, and reflects the light from a source held close to the patient's symphysis pubis; or a good direct light from a window will suffice. Upon withdrawing the obturator, the pelvis being elevated, the bladder becomes distended with air. If a pool of urine remains in the bladder, it should be withdrawn by a suction apparatus made for the purpose (Fig. 142). If the residuum is not Fig. 142. Suction Apparatus (three-fourths natural size), used for withdrawing residual urine (Kelly). more than 2 or 3 cubic centimeters, it can easily be removed by little EXAMINATION IN GENERAL. 165 balls of absorbent cotton grasped with a long mouse-toothed forceps. In some inflammator}'^ cases the bladder will not balloon out in the ordinary position, owing to its thickened walls. Then the genu-pec- toral position (p. 140) is used. This position is, upon the whole, best for a first examination. If the patient cannot remain long enough in this position, its advantages may often be secured by placing her for a short time in that position until the viscera gravitate up and out of the pelvis, and introducing a catheter into the bladder, which at once fills with air. The catheter is now withdrawn, and the patient gently returned to the dorsal position with more or less elevated hips. Upon introducing the speculum the bladder will be found distended with air. In nervous patients it is often best first to make a thorough examina- tion under anesthesia. A pledget of absorbent cotton saturated with a 5 j>er cent, solution of cocaine and left for five minutes in the urethra greatly facilitates the dilatation and is often the best form of anesthesia.^ The ureters may be examined by inspection, by catheterization, and by palpation. With the galvanic cystoscope the ureteral openings can be seen, as well as the discharge of urine that takes place through them. In cases of unilateral pyelonephritis clear urine is seen coming through one of the openings, and a purulent fluid through the other. Casper's improved galvanic cystoscope allows one also to introduce a fine flexi- ble catheter into the ureter. If Kelly's bladder-speculum is used, by elevating the handle of the instrument the field of vision sweeps over the base of the bladder until the region of the interureteric ligament comes into view, often marked by a transverse fold or a distinct difference in color. By turning the speculum thirty degrees to one side or the other and look- ing sharj)ly, a ureteral orifice is discovered. In order to ascertain that it is the ureter which lies in the field, a searcher — that is a long deli- cate sound with a handle — is introducetl through the speculum into the supposed ureteral opening. If it is the ureter, the searcher passes easily from 2 to 6 centimeters up the canal. The searcher may then be replaced by a metal catheter or by hard-rubber bougies, which lat- ter may be introduced before hysterectomies and prevent injury to the ureters during the operation. After some practice it is possible even to catheterize the ureters with the patient in the dorsal position Avith- out elevating the pelvis. Commonly a s})eculum 10 millimeters in diameter suffices for inspection, catheterization, and treatment of the ureters. On withdrawing the stopper of the catheter a few droj)s of urine run out, and then cease, keeping up an intermittent discharge en- tirely characteristic!. 'J'he catheter can l)e ])ushed beyond the brim of the pelvis, up to the pelvis of the kidney, by introducing an ' Howard Kelly, Amcr. Jour. (Jbd., January and July, 1S<J4. 106 DISEASES OF WOMEN. index-finger into the rectum, and lifting and guiding the catheter while it is being pushed up. Sometimes the ureters may even be catheterized without anesthetizing the patient. Galvanic Cydoscopy. — By means of Casper's cystoscope (Fig. 143),' a minute electric lamp is carried into the interior of the blad- FiG. 143. li Casper s ureter cystoscope : li, movable lid covering groove in which moves c, the ureteral catheter; d, handle of lid; o, ocular end; p, prism; I, lamp; s, screw for making and breaking connection with the battery; vi, mandril. der, which it illuminates to perfection, and not only allows one to see the openings of the ureters but to catheterize them, and thus obtain the urine separately from each kidney. This instrument has somewhat the shape of a lithotrite and is introduced without dilating the urethra. Palpation of the Ureters. — When there is no disease the ureters can usually be felt with facility as more or less flat cords about one- eighth of an inch in diameter, movable to an extent of one-half to three-quarters of an inch, in the loose pelvic connective tissue at the side and in front of the cervix. The patient may be in the dorsal position, and both hands used, the homonymous index-finger in the vagina [i. e. the left for the left ureter, the right for the right), or she may be in Sinis's position. In botli positions the vaginal roof is pushed well upward, when the ureter may be felt, hooked, brought down, and compressed. A practical and safe method of obtaining urine from one ureter alone is very desirable in order to locate and treat disease there, and to ascertain the presence and healthy condition of the second kidney, when the removal of one is contemplated. Many attempts have been made to accomplish this end, but they were either unreliable, or necessitated bloody operations, or a dan- gerous distention of the urethra, or exposed the patient to the risk of having a healthy ureter infected by carrying germs from' the bladder into it, when the latter was itself infected from the other diseased ureter. All those evils are avoided by the simple and in- genious method invented by Dr. liose, of Hamburg.^ He uses a ^ The instrument and its use are described by Willy Meyer in the New York Med. Jour., Mar. 21, 1896. ^ H. Rose, " Ein Neues Verfahren, bei der Frau den Urin beiden Nieren gesondert empzufangen," Centralbl. f. OyndL, vol. xxi, No. 5, p. 121, Feb. 6, 1897. EXAMINATION IN GENERAL. 167 steep elevated-pelvis position, in which the bladder, and especially the region next to the inner opening of the urethra, becomes the highest point of the abdominal cavity. The symphysis pubis and the recti muscles prevent the bladder from ascending, and when it becomes distended by air it is driven downward. Therefore, the inner urethral opening and the openings of the ureters lie near it, remain the highest points, and the urine must sink into the air-filled bladder until the latter is tilled with urine. In the meantime, the examination of the ureters takes place by means of a specially con- structed speculum (Fig. 144), cut off slantingly, so as to adapt itself Fig. 144. Rose's vesical speculum, one-hnlf natural slzo. better to the opening of the ureter. It has an obturator and a handle. It is made of nickel-plated German silver, and comes in tAvo sizes, one 2 centimeters longer than the other. In fat patients the longer one is the better. The longer instrument may also be used in lean persons, but here a shorter one is more convenient. In order to avoid too great a distention of the urethra, the lumen of the speculum is 1 centimeter. On the shorter side is a scale, which may be read off by an assistant. The urethra i)eing 2^ to 3 centimeters, and tlie distance from the inner ojxMiing of the urethra to the o])(!n- ing of tiie ureter about the same, the de])th to wliich the speciihim should be introduced is about o.L centimeters on the scale. It is necessary to anesthetize the urethni and l)hidder with cocaine (a 5 per cent, sohition applied for five minutes), and to dihite the urethra with conical dilators, either Simon's (Fig. Ill, |>. 145) or Kellv's (Fig. 145). Jt is best to shave the hairs off next to the meatus, "^fhe pliysi- cian stands between the legs of the patient, which are separated as much as possible. Tiie labia are lield apart by an assistant, who stands on the side wliere the ureter is to be insj)ected. At first the 168 DISEASES OF WOMEN. handle is pointed straight upward. The outer end of the speculum is somewhat lowered, and the speculum introduced 5^ centimeters. Upon removal of the obturator, one sees plainly, by good daylight or by gas-light and a head-reflector, or by an electric head-lamp, the lower part of the anterior wall of the bladder. Next, the instru- ment is applied to the wall of the bladder, and the outer end moved in the direction opposite to that of the ureter that is to be examined, at the same time lifting it a little and rotating it so as to turn the handle outward to the side where the ureter is, and then downward until it comes to stand about in the middle of the lower quadrant Fig. 145. Kelly's Urethral Dilators. of the urethra, on the side where the ureteral opening is to be inspected. The ureteral opening is recognized by its form, which is that of a little mound with a depression. Sometimes the mound is absent, and one sees only with great difficulty a fine semicircular slit. Finally, there are cases in which nothing denoting the presence of the ureter is visible, and then the only w'ay of finding it is to look for the periodical spurting of the urine through the opening. Another and still simpler method of obtaining the urine separately from the two kidneys, in either sex, is that of Harris, of Chicago.' Harris's instrument (Fig. 146) consists of tw^o catheters partly enclosed in a common sheath, and movable on their longitudinal axis within the .sheath. At the proximal end of each catheter (in regard to the patient) are three or four small holes ; to each distal end is attached a rubber tube leading to a separate vial, the stopper of which is perforated by two tubes, one in connection with one of the catheters, and the other with another rubber tube leading to a single exhaust-bulb. The patient being in the litliotomy position, the double catheter is introduced just as any other catheter, but as soon as it enters the bladder, which can be seen by the scale on the ' M. L. Harris, "A New and Simple Method of Obtaining the Urine Separately from the Two Kidneys in Either Sex," Jour. Amer. Med. Assoc, Jan. 29, 1898, vol. XXX., p. 236. EXAMINATION IN GENERAL. 109 upper surface of the sheath, each catheter is turned so that the inner end points backward and outward, the angle between the outer ends subtending an arc of 120 to 140 degrees, in which position they are held by a spiral spring. The inner ends will then be in the neigh- borhood of the openings of the ureters. Next, a metal rod is intro- duced into the vagina (or into the rectum of the male). By gentle Fig. 146. Harris' instrument for collecting the urine separately from the two kidneys; «, catheters turned down; b, sheath with scale; c, vaginal rod; dd, vials fur collecting urine ; e, exhaust-pump. pressure forward in the medium line the base of the bladder is raised into a longitudinal fold between the ureteral openings, forming a water-shed between tiie two, so that each catheter lies at the bottom of a separate ])()eket. IW producing a gentle exhaustion of the air in the vials by means of the bulb, the urine, as fast as it escapes from the ureters, drops directly into the ends of the catheters, and flows at once into the vials, right and left, respectively. F. Examination nmler anesthesia is, of course, only used in more im- portant cases, since the j)rocess always contains an element of danger; but this is so small, and the benefit to be derived for the diagnosis so great, that this means of investigation is perfectly justifiable. Some women contract their nuiscles so })ersistently that it is imj)ossible to make a thorough examination without having recourse to this means, when often the existence of a condition calling for active interference will be brought to light. G. Explnratorn aspiration is used less now than it was some years ago. It is done in order to ascertain tlie presence of a fluid oi' to obtain a sann)le of sucli fluid for examination. If the Huid is IJiin, it may be drawn out by the common hyjXKlcrmic syringe. l*^)r use in the vay-ina such a svrin<i:e has been made with a lonwr needle and 170 DISEASES OF WOMEN. an attachment by which the piston can be pulled out (Fig. 147).^ In most cases it is preferable to use a real aspirator, such as Dieulafoy's, Potain's (Fig. 148), or Emmet's. Even the finest hypodermic nee- FiG. 147. Exploratory vaginal syringe. die ought to be carefully disinfected before being plunged into the interior of the body, and the same precaution ought to be taken in regard to the skin it is going to perforate. As a rule, a cavity once entered should be totally emptied in order to prevent the fluid from finding its way into the peritoneal cavity. As this may be very tedious, a syphon action may be substituted for the aspiration by attaching a rubber tube to the needle and placing the other end, armed with a plunger, in a vessel with water. Aspiration ought never to be performed in the office or dispensary, and the patient ought to be kept in bed for four days. In order to les.«en as much as possible the danger of wounding blood-vessels, the finest instrument that will do the work is preferable, and it ought to be introduced slowly, so as to push arteries aside which it might meet in its way. If the puncture is made through the skin, the opening should be pressed together from side to side and covered with a piece of rubber adhesive plaster. (Compare " Tapping," under Treatment of Ovarian Cysts.) H. Exploratory Incision. — With the increasing innocuousness of opening the peritoneal cavity the exploratory incision has to a great extent replaced exploratory aspiration. It is, of course, in many cases only the first act of a capital operation, and must therefore only be undertaken by a person qualified to perform the latter, and after all preparations for such an operation have been made. The incision may be made through the abdominal wall or through the vagina. The incision in the abdominal wall is not made larger than is necessary to clear up the existing doubt, for which purpose the introduction of one or two fingers often suffices. As a rule, it is made in the median line and so that the lower end of the incision comes to lie two finger- breadths above the symphysis pubis. The exploratory incision in the vagina may be made in the anterior or the posterior vault. In most cases an opening in the posterior vault large enough to admit two fingers allows us to explore the whole ' Campbell, southwest corner Lexington Avenue and Thirty-fourth Street, has made such a syringe for me. EXAMINATION IN GENERAL. 171 pelvis, and, this being the simpler operation, it should, as a rule, be preferred.^ The incision may be made either transversely at the utero- vaginal junction, or perpendicularly, extending from the cervix to the bottom of Douglas's pouch. In exceptional cases the anterior incision is preferable, which involves the separation of the bladder from the uterus (see Vaginal Hysterectomy). Aspirator. This instrument consists of a clear glass bottle, with a Kraduatod scale showing the amount of fluid contained. It is closed by a rubber stopper. ihrout;h the centre of which a double-current tube, 2, passes. It is attached to an elastic hose, 3, with iin ex- hausting pump, 4, and another elastic hose, 5, with a stopcock, G. On the top of the latter tit needles ana trocars, 7, of difl'erent sizes. It goes without saying that the pvhe should be counted and its character noted, the fenipr rati ire measured with a clinical thernionietci-, and sucli other investigation.s made in regard to the condition of of/ier or(/anfi and the (/aieral Jicdltli of the patient as the case may call for. * Garrignes, "Vaginal Hvsterectoniv and ( )()i)liorectomy after Svni])hvsiotomv," Mc(l. Record, Feb. 2'.'>, 1895, vol. xlvii. No. 8, p. 'IM. PART VI. TREATMENT IN GENERAL. The treatment of gynecological diseases is preventive and curative ; the latter, again, is carried out by external manipulations, by the inter- nal use of drugs, or by electricity. CHAPTER I. Preventive Treatment. What can be done and is to be attempted in the way of pre- venting gynecological diseases, can easily be inferred from a study of the chapter on etiology, but the beginner must not be too sanguine in his expectations or too positive in his demands, if he will avoid disappointment or the loss of his patient. As soon as his advice clashes with that of the dressmaker or social habits, ninety- nine women will be decided by these last two factors for one who will follow the first. Where this antagonism does not come into play, much good may, however, be done by timely warning. At puberty girls should not be exposed to mental overwork, and at no time should the practice of music be carried so far as to engen- der nervousness. All sexual excesses and unnatural practices should be avoided. The skin should be kept clean. The muscles should be strengthened by exercise and games. Some time, at least an hour every day, should be spent in the open air. Good, wholesome food should be taken at proper times, and in sufficient quantity to make up for the physiological tissue-consumption. The bladder should be emptied when a desire is felt to do so. An evacuation from the bowels should take place once or twice a day. The body should be sufficiently covered, especially in the cold season. In winter time women should wear woollen drawers, but they should not be " closed," as this tempts to neglect proper evacuation of the bladder. Corsets ought to be banished from the dress of children, girls, and young women. All of them ought to go early to bed — as a rule, not later 172 TREATMENT IN GENERAL. 173 than ten o'clock. During menstruation they should carefully avoid exposure, violent exercise, or sexual intercourse. If suffering from chronic pelvic inflammation they had better abstain from marriage. Good midwifery, both as to surgical help and conscientious use of antiseptics, not only in hospitals, but in private practice,^ goes far to prevent later disease. Puerperse should be kept in bed until the uterus has receded into the pelvis. Lacerations of the cervix and the perineum, if not healed immedi- ately after delivery, should be repaired by the proper operations before the bad effects consequent upon them make their appearance. Women should be told to what enormous dangers they expose them- selves by availing themselves of abortionists, and miscarriages should be treated with great care according to the tenets of modern mid- wifery, and especially all the products of conception should be re- moved. Antiseptic precautions should be taken as far as feasible, even in minor gynecological operations and examinations. A man who has had a gonorrhea should not marry before a careful examina- tion by a competent judge has ascertained that he is perfectly cured. ^ The writer has since 1883 repeatedly called the attention of the profession to the importance of aseptic and antiseptic midwifery. He was the first to in- troduce strict antisepsis in this country. On the first day of October, 1883, the whole arrangement of the New York Maternity Hospital was changed, and the results were so striking that the example was soon followed by others, and that the treatment then inaugurated has been kept up ever since with insignificant modifica- tions. His first report was given in a paper on "The Prevention of Puerperal Infection " read before the Medical Society of the County of New York, and pub- lished in the Medical Record, December 2d, 1S83, vol. xxiv., pp. 703-706. Soon followed an article under the same title, especially on the use of injections, published in the New York Medical Journal, March 1, 1884. Then came a paper on " Puerperal Diphtheria" published in TransuetionK, Amer. Gynecol. Soc, vol. x. 1885, pp. 9H-113. Next, he treated the whole subject of puerperal infection at greater length in book- form in his Practical Guide in Antiseptic Midwifery, Detroit, Mich., 1886, and in a long article on "Puerperal Infection" in the American System nj Obstetrics, edited by Hirst, Philadelphia. 1889, vol. ii. pp. 290-.378, as well as in a similar article in the American Text-book of Obstetrics, edited by Norris, Philadelphia, 1895, pp. 683-734. The article on "Corrosive Sublimate and Creolin " in Amer. Jour. Med. Sci., Au- gust, 1889, contained the only change he in the course of time found it advisable to make. in hospital practice strict antL'^epsis is now used everywhere, but in private ])rac- tice we lag yet in a deplorable way behind other coinitries, and the result is to be found in fre(iuent disea.se and death among the well-to-do, which have marly dis- apjx'ared from the lying-in hosjiitals. It is to be hoped that the general i)ra(titioncr soon will follow the lead of the expert obstetrician m this field. On motion by the writer the following resolution was unanimously adn|)t((l on October '27, 1S92: "In the opinion of the .'^ei'tion on Oi)stetrics and ( Jynccolo^'v of the New York .Academy f>f Medicine, it is the duty of every f)hysician practicini,' midwifery to surround sucii cases in private practice with the same safeguards that ;ire used in lios|iitais" ((Jarrigues, " Keprehensibic, Dei)atable, and Necessary Antiseptic Midwifery," Med. News, Nov. 26, 1892). 174 DISEASES OF WOMEN. CHAPTER II. External Treatment. A. Applications. — Applications of medicinal substances are made to the vagina or to the uterus. The patient is in Sims's position, the parts are exposed with Sims's speculum and my depressor (p. 149). After having wiped the mucus off with absorbent cotton, the vaginal vault is painted with common tincture of iodine, by means of a large camel's-hair brush on a long handle, or better, a small ball of absorbent cotton held in a forceps. As the iodine smarts when it reaches the vulva, care should be taken not to use too much, and to wipe the superfluous fluid off with absorbent cotton before the patient rises. In the vagina I prefer the common tincture of iodine to Churchill's, as I have seen the latter produce ulceration. For application to the interior of the uterus an applicator is needed. Most of the instruments offered for sale are either too elastic or too flexible, which makes it difficult to introduce them, or they have a shape that makes it hard to remove the cotton after the applica- tion. I have, therefore, had one made (Fig. 149) of rather thick Fig. 149. Garrigues' intra-uterine applicator. hard-rubber, which has just the desired degree of elasticity and is conical, which renders the removal of the cotton very easy. As the cotton occasionally will come off, while the applicator is withdrawn from the uterine cavity, it ought always to be so long that part of it remains outside of the cervix. By seizing this end wnth a pair of dressing- forceps and rotating the cotton, it is easily pulled out. A little absorbent cotton is fashioned so as to form a thin rectan- gular pledget, 3 inches long by 1 wide. The applicator is held at right angles a little inside of one of the ends and one of the sides, and the cotton is rolled round it with the fingers of the left hand, going down in a spiral line toward the handle. By a little practice it becomes easy to put it on smoothly and of variable thickness, according to the caliber of the cervical canal. The thick mucus that is often found in the cervical canal must first be wiped off with dry cotton, or, if this proves impossible, it is coagulated by ajiplying a mixture of equal parts of tincture of iodine, tannin, and carbolic acid. Some prefer to make applications to the inside of the uterus by means of a glass pipette, or through a cervical speculum (p. 152). TREATMENT IN GENERAL. 175 If the canal is too narrow, it must be dilated (p. 156). For the endometrium, I use mostly Churchill's tincture of iodine, liquor ferri chloridi undiluted, chloride of zinc (20 per cent.), and occasionally sol. argent, nitrat. 1 to 12, or pure carbolic acid. As some patients are extremely sensitive to intra-uterine appli- cations, it is best to restrict the first application to the cervix, and gradually penetrate into the cavity of the body up to the fundus. Uterine and vaginal applications are, as a rule, repeated twice a week. Medicinal applications are also made to the skin of the abdomen, especially tincture of iodine or an ointment of equal parts of ichthyol and lanolin. These applications are repeated once a day. In ^Jg- 150. septicemia, inunction once a day with unguentum Crede, which contains soluble silver, has ac- quired great reputation. B. Injexitioiis. — Injections are made into the vagina, the uterus, the rectum, and the bladder, with plain or medicated water, by means of a syringe. Vaginal injections are used to greatest advantage in the dorsal position on a douche-pan (Fig. 150). A good douche-pan should be large, and have an opening near the bottom with an attached rubber tube to carry off the water into a larger vessel placed under the l)ed. If it does not have such a contrivance, and is not large enough, the water may be gradually pumped out by means of a bulb-and-valve syringe (Davidson's syringe) while running into the douche-pan. Patients who arc obliged to help tlicmsclves may also take their vaginal douche sfcmding over a vessel placed on a cliair, or sitting on a bidet. It is best to use a foimfain ftj/rinf/e ; that is, a bag of soft rubber, or a metal pail, a so-called donohe-can with a long soft-rubber tube and a nozzle of metal or, perferably, hard rubber. The nozzle should have holes only at or near the v.\u\, and it should be pushed in so far that the openings are behind and above the os uteri. If there are Douche-pan: A, tube closed unless used to make connection with rubber hose leading to vessels jjlaced under the bed. 17G DISEASES OF WOMEN. side openings lower down or the nozzle is not introduced to the proper depth, an opening may face the os and some fluid be injected into the uterus, which gives rise to a very painful and alarming uterine colic. If the chief aim of the injection is to combat inflammation and cause absorption of inflammatory exudations, plain hot water is the best. The amount should not be less than two quarts. The tem- perature should be as high as the patient can stand it — i. e. so that she can just hold her hand in it (110° to 120° F.). In exceptional cases hot water increases instead of relieving pain, and is then advan- tageously replaced by lukewarm water. Cold injections are injurious. For merely cleansing the vagina — for instance, when a pessary is worn — a pint of tepid water suffices, and its effect may be increased by adding a heaping teaspoonful of common salt or bicarbonate of sodium. If an astringent is called for, alum, borax, or equal parts of sul- phate of copper and alum are dissolved in the water. Of alum or borax, a teaspoonful is added ; of the mixture of copper and alum, only half a teaspoonful. If there is a spongy os uteri giving rise to hemorrhage, I use half a teaspoonful of the liquor ferri chloridi to a pint of water. For antiseptic injections carbolic acid (1 to 2 per cent.), creolin, or lysol (^ to 1 per cent.) is used. Creolin is also an excellent hemo- static, but in some patients it produces a smarting sensation. Bichlo- ride of mercury should be avoided, except for gonorrhea, on account of its poisonous properties,^ and the solution should not be stronger than 1 to 3000 or even 5000. As an emollient injection a decoction of flaxseed tea or slippery-elm bark, a heaping teaspoonful to each quart of water, is good. Vaginal douches are, in chronic cases, as a rule, used morning and evening, and in acute three times a day, or even every three hours. Intra-uterine injections are much more dangerous than vaginal injections, and should always be administered by the physician him- self. We distinguish between small and large intra-uterine injections. The former are really only applications of drugs made on a larger scale. The injection is made by means of a small glass syringe with a long nozzle, with one or more nne openings near the end (Fig. 151). Having seen several cases of alarming colla])se follow the use of this method, and knowing that it has been fatal in the hands of others, I have entirely discarded it. Large uterine injections are used for cleaning and disinfecting the uterus and for checking hemorrhage. If the cervix has been thor- oughly dilated before injecting, a single-current tube is preferable, as it leaves more room for evacuation of large debris. For this purpose ' Garrigues, "Corrosive Sublimate and Creolin in Obstetric Practice," Amer. Jour. Med. Sci, Aug., 1889, vol. xcviii. pp. 109-128. TREATMENT IN GENERAL. Ill I find the so-called soft-metal male catheters sold in the stores of the instrument- makers very convenient, as they are easily bent so as to adapt themselves to any shape of the uterine canal. By adding a flange at the open end, connection is easily established with a fountain Fig. 151. Brauii's Uterine Syringe. syringe (Fig. 152), If the cervical canal is not so wide, a double-cur- rent uterine tube (Fig. 153) should be used. AVhen it is of import- ance to bathe the whole inside, cervix and body, it is best to use two Fio. 152. < ^r . -..—■: . ^ . Garrigues' Single-current Intra-uterine Tube. single-current catheters, a thinner afferent and a thicker eiferent. The fluid then comes out partly through the thick tube and partly between and around both. The patient is placed on a tabic, unless she is so weak that it is deemed better to leave her in her bed, and only move her sufficiently beyond one edge to have a free back-flow from the vagina. The leg nearest the edge is placed on a chair. Whether she remains in bed or is placed on a table, a rubber sheet or oil-cloth is pushed in under iier buttocks, and })inned witli two ])ins so as to form a funnel, the lower end of which o])ens into a pail. If the patient is placed on a table, the inflatabk; rul)ber cushions mentioned on page 203 may also be used. Intra-uterine injections ought only to be given in the dorsal position in order to avoid the entrance of the fluid througii a possibly dilated tube into the peritoneal cavity. The vagina is first disinfected by injecting .some of the fluid and by swab- bing the wall thoroughly with large pieces of absorbent cotton dipped in the same. Cu.sco's specnhim is introduced. Tlie intra-uterine tube is attached to the tubing of the iountain .syringe, and, all air having l)een exj)elled, is pushed up to the fundus of the uterus while the fluid is turned on. The physician watciies tiie flow all the time to make sure that there is no ob.struction. I use about a quart for the vagina and from a j)int to a quart for the uterus. When the uterus is deemed to be sufliciently wa.'^hed out, it is .squeezed in order to remove all fluid from its cavity. Finally, the vagina is again douched, and the perineum (lej)ressed so as to allow all fluid to flow oil". For these injections I prefer crcolin (1 per cent.), as it is a non- 12 178 DISEASES OF WOMEN. poisonous reliable disinfectant and an excellent hemostatic. Lysol is also good, and has the advantage of forming a nearly clear mixture Glasgow's double-current intra-uterine tube. with water. I have never seen any untoward symptoms follow this kind of injections. If the patient is anesthetized, it is better to dilate the cervix, intro- duce a cervical speculum (p. 152), and introduce an intra-uterine tube through the speculum all the way up to the fundus. Rectal injections, enemas, or clysters are used for emptying the lower part of the bowels, or as a vehicle for medicinal substances to be ap- plied to the diseased mucous membrane, or to overcome an obstruction in the intestine, or to mark the course of the intestine (p. 161). If the object is only to cause a movement of the bowels, plain lukewarm water may be used, or a teaspoonful of salt may be added, or soap- suds or an infusion of linseed-meal (a tablespoonful to a quart) may be injected. In cases of constipation with impaction of hard feces the following is an excellent enema : a teaspoonful of inspissated ox-gall, a tablespoonful of glycerin, a tablespoonful of castor-oil, and a heaping teaspoonful of salt, to a quart of linseed-meal infusion. The ox-gaJl is stirred with the warmed glycerin, the oil is added, then the flaxseed tea, and finally the salt. For tympanites an enema with a teaspoonful of oil of turpentine, a tablespoonful of castor-oil, and a quart of soap-suds or flaxseed tea is good. All these enemas are given lukewarm. In diseases of the rectum often astringents or sedatives are used in injections. As the fluid in these cases is meant to be retained for some time, the amount should be small ( .5j to .5iv). After operations rectal injections of a pint of tepid water may be used to relieve thirst. Similar injections of very hot water may be used to combat collapse caused by loss of blood. All rectal injections arc best given with the patient lying on her left side. Evacuant enemas are preferably administered by means of a bulb-and-valve-syringe (Davidson's), but where it is desirable that as much water as possible should enter the bowel, the fountain-syringe used with very little pressure is by far better. Ordinarily, enemas are administered through a hard-rubber or TREATMENT IN GENERAL. 179 metal nozzle about two inches long ; but when it is desirable to carry the fluid higher, a children's nozzle is inserted into a soft- rubber rectal tube a foot long. If the object is not only to inject a certain amount of fluid, but to irrigate the intestine, Dr. Kemp's double-current tubes will be found useful. They are respectively five or twelve inches long. The shorter is made of hard or soft rubber, the longer one of soft rubber only.^ Vesical injections are used very much in diseases of the bladder. The patient occupies the dorsal position. For large injections Keyes's Fig. 154. Kfvuj^'s Irrigator for Bladder. irrigator (Fig. 154) may be used. It is essentially a fountain-syringe with a two-way stop-cfK'k, which allows alternately to fill and ein])ty the bladder simply by turning the stopcock. It may be used with any hard or soft catheter. Another good and simj)le apparatus for washing ont the bladder consists of a catheter, an intermediate piece of rublxsr tubing about two feet long, and a funnel. The funnel is held up during injection, and is brought down below the level of the bladder when we want to empty it, thus cstabli'^hing a si- phonage. Care should be taken to let as little air as ])ossible enter the bladder. Where shreds are to be washed out, Xotf's (louhfe-ciirrciif (•(ifhcfrr (Fig. loo) with its large eves will be found ' Kol)C'rt ('(.Icman Kt-nii), Xnr York Midiml Riro.-d, Doc. 7 and 11, IS!*."). 180 DISEASES OF WOMEN. to answer a good purpose. For smaller injections, Thompson's rubber bag with stopcock (Fig. 156), inserted into a soft catheter Avith hard Fig. 165. Nott's Double-current Catheter. rubber mouth-piece is handy. For the injections is used plain water, or solutions of chloride of sodium (1 per cent.), salicylic acid (1 per thousand), boracic acid (^ to 3 per cent.), tannin (^ to 1 per Fig. 156. Thompson's Rubber-bag with Stopcock. cent.), carbolic acid (^ per cent.), creolin (^ per cent,), permanganate of potassium (^ to 2 per thousand), nitrate of silver (2 to 5 per thousand), etc. The amount of fluid used varies from half a pint to a quart ; for small injections one to four ounces are used. Gen- erally the fluid should be lukewarm (95° F.), but as a hemostatic it should be hot or ice-cold. The irrigation of the bladder is repeated once, twice, or three times a day. Intravenous, subcutaneous, or intraperitoneal injedion of a hot solu- tion of 6 parts of chloride of sodium in 1000 parts of hot water (110° to 120° F.), or al)oiit a flat teaspoonful to a quart, is used with great benefit to counterbalance loss of blood in operations. (See Uterine Fibroids.) C. Curettage. — The instruments needed for scraping the inside of the uterus have been described in the preceding chapter fp. 155). The patient is placed on a table arranged forintra-uterine injection (p. 177). As the procedure is often protracted and painful, she ought to be TREATMENT IN GENERAL. 181 anesthetized.^ The vagina and uterus are disinfected with creolin (p. 177). The cervix is dilated (p. 156). The condition of the in- side of the uterus is ascertained by sound (p. 154) or finger. The index-finger is preferable if the cervix admits it. In introducing it counter-pressure is made on the fundus with the other hand. The nail of the finger is often used itself as curette. It is safer than instruments, but not so efficient. In gynecological cases I use the dor- sal position and introduce the curette through Cusco's speculum (p. 146j ; or if the patient is anesthetized, I pull the uterus down to the vulva with a tenaculum-forceps while the j)erineum and the posterior vaginal wall are being pulled back with a Garrigues speculum. The curette is moved up and down along the surfaces and edges and from side to side along the fundus. In cases of incomplete abortion I often turn the patient on her left side and work simultaneously with the left index-finger and a large dull-wire curette (Fig. 157).^ The Fig. 157. Large dull-wire curette. scraping should be continued until everything is removed and the inside of the uterus is smooth. Then the patient is turned back into the dorsal position. Finally, the uterus and vagina are again disin- fected, and a tampon is put in the latter until the following day. The iiemorrhage is not very considerable. It is very rarely neces- sary to renew the tampon. On changing it a vaginal injection with creolin or carbolic acid is given, and after its final removal twice a day as long as there is any discharge. The ])atient is kept in bed for four days. If then; is any pain, which is an exception, an ice- bag is applied over the symphysis and the patient is given an opiate. The curette should only ])e used for scraping in the direction from the fundus to the os and along the fundus, but never in going from below u])ward. In moving the curette u]) toward the fundus great gentleness should be used, as otherwise the instrument may ])er- forate the uterus. If this should happen, the beginner need not be particularly alarmed. It has happened twice to me, and no bad consequences were observed, but in such a case it is necessary to desist from washing out the ut(!rus, an omission whi(^h, of course, in other respe(;ts is undesirable. The smaller the loo]) of tlu^ curette, tlu; greater is the danger of ])erforation. AVe should, ' This ap[)lieM to strictly pynccdloirieal cases; in cases of licmorrliajre due to recent abortion, anesthesia may be (iisi>(;iise(l with except in very nervous women. ' I call ail dull-wire curettes Thomas's, whether they are jarj^e or small ; hut the instrument is also known as ^f un(l<'''s (see Ciarrigues, " 'I'he 'Ireatment of Abortinn'), Medical Newx, Nov. 6, 1897, and .Jan. 1, I89H. 182 ' DISEASES OF WOMEN. therefore, always use as large an instrument as will enter the cer- vix and is in reasonable proportion to the mass to be removed. In cases of incomplete abortion before the end of the second month, when the large dull wire curette does not enter, Becrnnier\s curette (Fig. 158) is sometimes useful. It is made of steel, and has either dull or cutting edges. Physicians wlio are not quite familiar with the aseptic and anti- septic treatment, or who have not an educated sense of touch, had better abstain from performing curettage. Simple as the o])cration is, it has cost more than one woman her life. Large j)elvic abscesses have been produced, and the most fearful direct injuries have been inflicted. Unskilful hands have not only perforated tlie uterus, but have taken hold of the intestine and torn it loose from its mes- entery or severed it, causing gangrene of the intestine, and death. The only remedy is prompt laparotomy, repair of the intestinal injury (see Appendix), and suturing of the wound in the uterus.^ D. Tamponade. ^-Thc word tampon is French, and means a small mass of cotton or other soft material which is carried into a wound or cavity for the purpose of filling it, so as to prevent hemorrhage, or applying drugs to it, or exercising pressure on it. A tampon being used for such very different purposes, becomes a very different thing, and we will, therefore, consider separately the application of medi- FiG. 158. R^camier's Curette. cated pledgets in the vagina, the packing of the vagina, the hemo- static vaginal plug, and the tamponade of the uterus. Pledgets in the Vagina. — Small rolls of absorbent cotton, about 2J inches long and 1 inch thick, with a string of strong crochet- yarn fastened round the middle and made long enough to hang an inch or two outside the vulva, are impregnated with some medicinal substance and pushed uj) to the posterior vault of the vagina. They are, as a rule, withdrawn morning and evening, when an injection is made and a new pledget put in. The cotton may be impregnated witli different substances. The best in my experience is ichtiiyol dis.solved in glycerine (5 per cent.) ; but in some cases the ichthyol irritates the vagina, so that it becomes red and smarts. Then plain 'M. D. Mann, Amer. Jour. Obs., May, 1895, vol. xxxi, p. 603. H. .T. Boldt, Moruilsschrift fiir Geburtshiilfe und Gyndkoloqii', vol. ix, p. 360. Albert!, Centrulbt. f. Gyndk., 1894, No. 39, vol. xviii, p. 939. TREATMENT IN GENERAL. 183 glycerine must be substituted. Another good resolvent combina- tion is : ^. Potassii iodidi, gr. xxx ; Acidi borici, gr. xl ; Glycerini, q. s. ad siij. As an astringent, for instance, for a spongy cervix, tannin-glycerine (10 per cent.) is very efficient. Others prefer lioroglyceride or sul- phate or acetate of aluminium, in the proportion of .5J to glycerine Oj.' All these applications containing glycerine produce a watery discharge, relieve pain, and scatter swelling. If the discharge is free, and especially if ichthyol or tannin is used, which stain the linen, some kind of napkin or pad should be used. Packing of the vagimi differs from the application of a pledget, as heretofore considered, in being a combination of medicinal action and pressure in the treatment of diseases of the uterus, ovaries, and peri- uterine structures. The patient is placed in the knee-chest position, Sims's speculum is introduced, and the vagina is packed tightly with pledgets of cotton so as to form an inverted coniform column, filling the posterior cul-de-sac and resting on the pubic arch and the peri- neum below. The uppermost pledget, which covers the cervical portion and part of the vaginal roof, should be saturated with pure glycerine, or better, the above mentioned solution of iodide of potas- sium. The others are rolled into cylinders and put in dry. A nurse withdraws the tampon after thirty-six hours, when a hot douche is given. The columnizing is repeated two or three times a week.^ It is claimed that by this method adhesions may be lengthened, cicatrices stretched, exudations absorbed, congestion relieved, and the vagina lengthened ; but the writer is somewiiat skeptical as to the possibility of exerting any pressure in this way, and thinks that the same results are obtained in an easier way by the use of medi- cinal pledgets, by painting the vaginal roof with the tincture of iodine, or by electrolysis. TJic Jfnnosf((fie Vaginal Plug. — Plugging of the genital canal is one of the most potent remedies against hemorrhage. A vaginal plug must be put in in such a way as fully to distend the vagina, for which often two dozen good-si/ed j)ieces of cotton are necessary. One or two sheets of al)sorl)ent coftou, a foot S(juare, shotdd be im- mersed in a 1 ])er cent, emulsion of creolin, s(jueezed dry, and torn into strips, which arc folded so as to form flat scpiares which may be packed very tightly. The creolin imj)arts both styptic and anti- septic ])roperties. The first may also be obtained by immersion in 'Wiley, M>'(1 RrronI, October, 8, 1SS7. vol. xxxi, p. AHli. ^ Natlinii Hozemanii, "The Wiliie of (inidiiatcd Pressure in the Treatinetit of Diseases of the N'agiiia, Uterus, (^varies, and other Appendages," All'tntu Midiad Retfinter, January, ISSI}. 184 DISEASES OF WOMEN. an alinn solution, the latter by using carbolized water (1 per cent.).^ When there is much bleeding from an accessible surface — e. g. after curetting a cancerous cervix — the tlu'ce or four upper pledgets which immediately touch the cervix should be wrung out of a mixture of one part of liq. ferri chloridi and ten parts of water. The liquor should never be used undiluted on a tampon. I have seen it cause deep ulcers which took weeks to heal, and the removal of the tampon is very ])ainful. Bichloride of mercury is not good for tampons, as by imbibition with blood they lose their antiseptic properties. Instead of cotton batting, a roller bandage, lampwick (Foster), or, if nothing else can be obtained, clean pocket-handkerchiefs, may be used, all of Avhich ought to be treated with disinfectants. A strip of iodoform gauze four finger-breadths wide is good, and may be made more antiseptic and styptic by powdering it with equal parts of iodo- form and tannin. The iodoform gauze acts at the same time as a drain, and is, therefore, particularly appropriate in the treatment of cancer, but on account of the very porosity of this material I would not relv on it in severe hemorrhaa-e. The vaginal tampon is best a])j)lied in Sims's position and with Sims's speculum. The rectum and bladder having been emptied, the first pledgets are placed around the cervix and then over it, and the same princijile should be followed if a continuous long strip of some kind is used. Whatev^er we use should be evenly and tightly put in with a strong pair of dressing-forceps until the vagina is filled all tiie way down to the entrance (but not the vulva). If the patient cannot pass her urine spontaneously, it must be drawn four times a day, but that is an exception. The tampon should be removed and, if necessary, renewed within twenty-four hours, except if made of iodoform gauze, W'hen it may stay in for five or six days if necessary. In exceptional cases of severe hemorrhage the vulva, too, must be filled and two tightly-rolled towels placed on the ])erineum and held tightly pressed against it by means of a bandage which surrounds the ])elvis, and from which one or preferably two tails are carried between the thighs and fastened in front to the band surrounding the pelvis. If a strip of some substance has been used, all that is necessary for its removal is to ])ull on the lower end, which should be left hanging just outside the vulva. If cotton pledgets have been em- ployed, the patient is again placed in Sims's position, Sims's speculum is introduced a short distance, some pledgets are pulled out with the dressing-forceps, and the speculum is gradually ])ushed farther in until the whole tampon has been removed. Then the patient is turned on her back and given a vaginal injection with creolin.^ ' A stronger solution takes off the whole epithelium. ^ To attach a string to each pledget does not facilitate their removal. The so-called kite-tail, made by tying all the pledgets to one string, is indeed more easy to remove, but more troublesome to put in. TREATMENT IN GENERAL. 185 Tamponade of Uterus. — For the uterine cavity only iodoform gauze should be used. This method is not only used to great advantage in post-partum hemorrhage, which does not concern us here, but like- wise for many gynecological conditions, either as hemostatic or for applying medicinal powders or fluids to the mucous membrane of the womb, or for causing changes in the structure of the uterine muscular tissue, especially in chronic endometritis and metritis, and even in order to cause depletion from intlamed appendages. It is used both in the cervix and in the body of the womb. Even a nulliparous uterus will admit a strip of gauze 8 inches long and ^ inch wide. On account of the antiseptic properties of the iodoform the intra- uterine tampon may be left undisturbed for five or six days. I have constructed a forceps for its aj)plication through an undi- lated cervix (Fig. 159).^ But, as a rule, the cervix should be pulled Fiu. 159. Garrigues' cnrved intra-uterine packing-forceps. down to the entrance of the vagina with a bullet-forceps and dilated with Hanks' dilators. The uterus should be curetted and washed out through Burrage's cervical speculum (Fig. 12(j, p. 152), with a single-current tube (Fig. 152, p. 177) reaching to the fundus, and the uterine cavity packed with a strip of iodoform gauzt; 2 inches wide and folded so as to form four layers ^- inch wide, the end of which Fk;. ino. (iarrigucs' straiglit iiitra-uteriiic packiiig-fnrcciis. strip is left hanging in the vagina, and a pad of the same inatcriMl is placed in the vagina. The gauze is pusiied through the spccuhini by means of a straight forceps (Fig. KiO). ' Amer. Jour. ()hs(., vol. .xxv. No. 1, Jamiarv, 1 N'Jl*. 186 DISEASES OF WOMEN. Abdominal Tampon. — The iodoforra-gauzc tampon is even used in the abdominal cavity. Sometimes there may be considerable oozing of blood after a laparotomy, which does not yield to hot water poured into the peritoneal cavity. In such cases the hemorrhage is some- times checked eifectually by packing the pelvis with iodoibrm gauze through the abdominal wound. The end is left hanging from the lower end of the woimd, and in closing the same one or two of the lowest sutures are left untied till the next day and the removal of the tampon. In the mean time suflficient adhesive matter has been formed to shut off the abdominal cavity from that part where the tam])on was put in, but the adhesions are, of course, weak, and it would be too great a risk to use injections through the wound. It is a good plan first to introduce the centre of a large square piece of iodoform gauze and make a pouch of it, which is subsequently filled with long strips of gauze the ends of Avhich remain outside (jSIickulicz's method). This tampon acts not only as a plug, but at the same time, on account of the porosity of the gauze, as a drain. Sometimes it is necessary to combine the intra-abdominal tampon with one in the vagina. In order to remove the abdominal timipon, each strip is pulled out separately and finally the surrounding gauze by pulling on a strong silk thread inserted for that purpose in its center before introducing it. E. Hemostasis. — Besides the hemostatic tampon, of which we have just spoken, other means of preventing or checking hemorrhage are available: hot loater, styptics, cauterization, ligature, suture, and ford- pressure. Hot water is used to check hemorrhage during operations. Thus a stream of some hot antiseptic solution or plain sterilized water may be kept continually flowing over the field of operation' or may occasionally be directed against the bleeding surface. At the end of laparotomy hot water is often poured from a pitciier or through a glass tube, as thick as a finger, right into the peritoneal cavity. Hot-water injections are also used as a hemostatic independently of operations, both in the vagina and in the uterus (pp. 176, 177). Styptics, especially alum, tannin, and chloride, persulphate or sub- sulphate of iron (Monsel's solution), are used as applications (p. 174), on tampons (p. 181), or in injections (p. 176). The undiluted liq. ferri chloridi or subsulphatis may be applied with cotton to small bleeding surfaces. Diluted with 10 parts of water, it may used in injections or left in on a tampon. A very convenient way of using styptics on small wounds is in the shape of dry stypdic cotton as sold in the drug stores. Ferripyrine (p. 174) may be used as dry powder or in strong solution (20 per cent.). Cauterization is an excellent hemostatic and, at the same time, an 'Geo. Engelmann, of Boston, Trans. Amer. Med. Assoc, 1885. TREATMENT IN GENERAL. 187 antiseptic; but as it leaves an eschar, it cannot be used where heal- ing by first intention is aimed at (nor can styptics). The dry heat of the actual cautery is so powerful a hemostatic that it may even be used to sever the pedicle of an ovarian tumor without using any ligature. A very convenient apparatus is Paquelin's thermo-cautery (Fig. 161), in which a tip of platinum may be kept at different degrees of heat by a more or less abundant supply of benzine vapor. Fig. IGl. Thermo-cautery. Independently of its hemostatic effect, cauterization is often used as an antiseptic to sear a wound surface, and thus make it impene- trable to bacilli. Some use it, for instance, on the stumps left after removal of the ovaries or the uterus. Cauterization by means of the r/dhano-cautery will be described under Electric Treatment. Vaporization. — Steam may be led from an apparatus like a steam atomizer, through rubber tul)ing and a metal nozzle with fine holes, into the interior of the uterus for half a minute or a minute. This method, called vaporization, is highly recommended as a preventive in all operations in which th<; uterine cavity may become a source of infection — e. r/., hysterectomy or myomectomy.' Vaporization niay also be used to check hemorrhage in other locali- ties, especially tiie liver or tlu; spleen. For the uterus I have found it efft'ctive after curetting ; but it sometimes gives rise to protracted puruh'ut discharge, and has caused atro])hy and atresia of tiie uterus. - Even a fatal case, du(! to secondary perforation and se])ti(^ peritonitis, has been reported.^ Lir/aftirc. — Spurting arteries or, more rarely, bleeding veins, may be ligated Avith silk or catgut, according to the general rules of sur- gery, but in gynecological ])raeticc we are oftener tiian in any other departments obliged to tie, not the isolated ]>leeding vessel, l)ut a more or less considerable inass of the surroiuidiiig tissue with it ' i'"erK)Tiicn()W, f'rulnilbLf. Gi/riiilc., ISOS, vol. xxii, No. '2.'), ]>. (iO'.>. '■^ SncRirefr, Jirrliinr Klinik; Apr., ]S9."). Jianicli, (Vnlntlhl. f. diiiiiik., Kcl). •"), 189S. ■'()|K'ration perforiiu'd l)v Treiil), reportfd liv \':iii de Veliie, Crvlni/hl. f. (hiniik., Dec. 31, 1898, vol. -x.xii, .No. W, j). 1 tOU. 188 DISEASES OF WOMEN. (wuws ligature). Arteries may be tied wliere they are severed or in continuity. Ligature of the Uterine Artery. — The uterine artery may be tied from the vagina. Modus Operandi. — Two assistants are needed besides the anes- thetist. The patient is phiced in the dorsal position witii raised knees or in the breech-back position (see Urinary Fistuhi). The cervical portion is exposed by means of short, broad, posterior, and anterior specuhi (see Hysterectomy), and seized with a bullet-forceps. A strong thread is carried through both lips in the median line. Before tying it, a strip of iodoform gauze may be introduced into the uterus, in order to keep all discharge from this organ away from the wound. By means of this ligature the uterus is pulled down and over to the side opposite that on which the operation is to be per- formed. The anterior blade is now removed, and a Schroeder lat- eral retractor (Fig. 193) is held against the wall of the vagina, so as to fully expose the lateral vault. At a distance of f inch outside of the utero-vaginal junction a fold of the vaginal wall is lifted with a tenaculum and cut (with blunt-pointed scissors, curved on the flat) in an antero-posterior direction at right angles with the base of tlie broad ligament. Next, one blade of the scissors is in- serted through the wound, and used to extend the incision backward and forward in a slightly curved line, the convexity of which points toward the side wall of the Fi(i. 1C)2. vagina, until the incision measures 1^ to 2 inches in length (Fig. 162). With both index-fino;ers the vag-inal tissue is separated laterally from the parametrium to the extent of nearly 2 inches. In a similar way the para- metrium is separated from the bladder and ureter in front and the rectum behind. By passing one finger be- hind and one in front of the para- metrium the whole mass, in which the main trunk and several branches of the uterine artery are felt throbbing, is grasped. The wound is kept well open by means of two lateral retrac- tors, and a strong silk ligature is car- ried with a Schroeder needle (Fig. 295), guided by the left index-finger, from behind forward, around the whole parametrium. The thread is seized with an artery- forceps, freed from the needle, tied tightly, and cut short. The ligature should be passed as far out to the side as convenient, ■ •'^v Ligation of Uterine Artery from th ■ Va<rina: a, vaginal portion; b, vaginal incisions sutured. TREATMENT IN GENERAL. 189 so as to include all branches of the artery. After irrigating the vagina with an antiseptic solution, the edges of the wound are united with a running suture of fine catgut, completely burying the silk ligature. To tie the ligature at such a great distance from the surface may be so difficult that catgut, in most cases, will be less appropriate. The handling-string and the gauze are removed from the uterus, and the vagina is packed loosely with iodoform gauze, which is removed after three or four days, and either renewed or replaced by antiseptic injections. The uterine artery may also be tied from the abdominal cavity after performing laparotomy (see Uterine Fibroids). Ligature of the Internal Pudic Artei-y. — As a rule, this artery should be cut down upon where it bleeds, making an incision in the Fig. 163. Lifjiition of the internal pudie artery in tlie Bluteal region : <i, skin; 6, fiiseia; r, Khiteiis innximus ninsele ; (/, pyriforinis nmsele; c, intorniil )ni(lic artery; /, interiml pudic nerve; (t, superlieial brimeli of gluteal artery; h, seiiitie artery; /, sciatic nerve; j, sciatic vein. jX'riiuMim parallel to the inner margin of the rami of the pul)is and ischium. Pxtth ends must be tied. It may also be tied in con- tinuity in the gluteal region, in the place wher(> the arterv runs i)ehin(l the spine of the ischium ( I'^ig. KJo). An incision H inches long is mad(! on a line extending from the middle of the spine of 190 DISEASES OF WOMEN. Fig. 164. the sacrum over the spine of the ischium to the trochanter. The fibers of the ghiteus maximus muscle are separated bhmtly and held apart with retractors, and the deep fascia is torn. The lower edge of the pyriformis muscle and the spine of the ischium must be well exposed. Under the edge of the muscle emerge both the internal pudic and the sciatic arteries. The latter is more superficial and passes outward. It is accompanied by the sciatic vein on the inner side and the sciatic nerve on the outer. The internal pudic artery is accompanied by the nerve of the same name on its inner side, and crosses behind the spine of the ischium to gain the lesser sciatic foramen, by which it re-enters the pelvic cavity. On account of the depth of the wound and the bleeding, this operation is, however, so difficult, that the great English surgeon Fergusson has stamped it as " an ingenious dis- secting-room proceeding." * Sometimes sutures are used for hemostatic purposes — e. g. a run- ning catgut suture may be put over a bleeding tear in the broad liga- ment; or an artery imbedded in tissue may be made to stop bleeding by passing a needle with thread under its course and tying ; or a bleeding surface of the abdominal wall may be excluded from the abdominal cavity by folding the wall, so as to press one-half of the bleeding surface against the other, and put sutures through from side to side as in a mattress {mat- h-ess suture). These sutures may be made more efficacious by using quills, a couple of lead-pen- cils or pen-holders serving as such. Foreipressure. — Much time is saved by sub- stituting a temporary strong pressure with Koe- berl^'s clamp (Fig. 104), a kind of artery- forceps with catch that has been modified by many other operators, and therefore goes under different names (Plan's, Spencer Wells's, Tait's, etc.). When made of proper size (Fig. 165) and left for twenty-four hours or longer, such forceps may be made to secure even the uterine and the ovarian arteries in the extirpation of the uterus; but in most operations small clamps, five or six inches long, are used temporarily, and re- moved toward the end of the operation Avhcn the bleeding is stopped. If, exceptionally, a vessel still bleeds, it may, of course, be seized again with the forceps and secured with a ligature. ^William Fergusson : "A System of Practical Surgery," fourth edition, London, 1857. Koeberle's artery-clamp (modified by Pean). TREATMENT IN GENERAL. 191 Angiotripsy is a peculiar development of forcipressure. An angio- tribe is an exceptionally strong pair of forceps, in which pressure is Long Pressure-forceps. exercised by means of a screw with a large head (Fig. 166). With it the tissue containing the artery to be closed is crushed, whereupon the instrument is removed. The angiotribe was originally used in vaginal hysterectomy to crush the broad ligaments. If (lifficulties are met with, especially when morcellation is needed, the inventor, Fig. 166. Tuflier's angiolribe. Tuffier, of Paris, uses first common compression-forceps, but at the end of tiie oj)eration he removes them all one after the other, and crusiios the tissue held by each with the angiotribe.' Others have used the instrument for other operations involving small or medium- sized arteries. It insures ])erfect hemostasis, and leaves no foreign body in tlie wound.^ F. J)il(ii(iii<)ii and (i. J)rain<i(/e art; .so intimately connected that we will treat of tiiem together. In regard to dihitation of the cer- vix the reader is referred to what has been said on tlie subject in the cha|)ter on Fxamination (pp. 1 56-15!*). Dr. Outerbridge of New York has constructed an ingenit)us insfrii- 'Tiiflier, Si-mninc Mvdimle, lKii7, p. 472, and ]8!)S, p. 'J3.',. • W. F. SchuItC'n, Ibiil., p. i:i)3. 192 DISEASES OF WOMEN. ment for pei'manent dilatation of the cervix and drainage of the uterus. It consists of a silver- or gold-plated steel wire (Fig. 167), made so as to form an anterior and posterior blade, with a slight eversion at one end and bent at right angles at the other. It is self- retaining, and varies in length and cnrvatnre. For its introduction the patient may be in Sims's or in the dorsal position. The univalve or bivalve speculum is introduced, the cervix steadied with a tenacu- lum, and the dilator put into the grasp of a carrier made for the pur- pose (Fig. 168). It consists of a fork with a movable ball and spiral spring sliding up and down a metal rod with handle. The dilator is introduced five or six days before expected menstruation, left in Fig. 167. Fig. 168. Outerbridge's Permanent Dilator of Cervix. during, and at least from five to eight days after the same, unless conception takes place and menstruation does not come on. The in- strument may be removed with a finger or by means of speculum and tenaculum or a blunt hook.^ Sometimes a perforated glass or hard-rubber stem is introduced into the uterus, and on the same principle I have had a glass vaginal plug made with an opening at the top. Iodoform gauze is used extensively for drain- age, either through the abdominal wall or the vagina. If there is much oozing from raw surfaces, or if pus or acrid cyst-fluid has found its way into the peritoneal cavity, it is ordi- narily best not to close the wound entirely after la])arotomy, but to leave one or two su- tures at the lower end untied, and to carry a long strip of iodoform ip. E. Outerbridge, Med. Record, April 20, 1889, vol. xxxv, p. 430. Carrier for Outerbridge's Dilator. TREATMENT IN GENERAL. 193 gauze from the bottom of the pelvis out through the lower end of the abdominal wound. If hemostasis is called for, the above-mentioned Mickulicz tampon is excellent, and will, at the same time, serve as drain, especially when part of its contents are removed (p. 186). Sometimes the pelvic floor is perforated, and the iodoform-gauze drain pressed into the vagina. Its upper end may be free in the abdominal cavity, or may lie in a pouch that does not communicate with the peritoneal cavity. It may be left in from two to eight days. If there is no contamination with pus, some prefer plain sterilized gauze. If there is no hemorrhage, soft-rubber tubes are also very useful as drains. Superficial abscesses may be drained through short thin tubes with side holes. A longer and thicker tube of this kind may be carried from an incision above Poupart's ligament into the vagina. If the drainage-tube is only introduced through an opening in the vagina into a space shut off from the peritoneal cavity, the drain Fig. 169. Single soft-rubber drainage-tube. Fig. 170. Double soft-rubber drainage-tube. Fig. 171. ■^ky rocket ilrainagc-tube. siiould have a T-shapo, the nj)p('r bar of the T serving as wings to retain the tiil)e in situ (Fig. KID). It is well to have a double tube, which facilitates washing out the cavity H'^ig. 170). The afferent tulx! should be thinner tiian the elferent and not have anv side holes. In large pelvic abseesses, the s/:i/ro<-/:<t <lr(ti)ui</(-liibc {V\\i. 171) is very 1:1 194 DISEASES OF WOMEN. useful. It consists of a short tliick tube, with lateral openings, and a long thin one without side lioles. The former has a lumen of f inch, and is 2^ inches long ; the latter has a lumen of ^ inch, and is 10 inches long. They are stitched together in three places. After the abscess has been opened from the vagina, the tube is in- troduced and the lower end of the short one is fastened with four silver wire sutures to the edges of the wound. The long tube may be closed with a clamp and is used for injections. The T-tubes are found in the instrument stores, but are rather expensive, and fairly good ones may be improvised with tubing. Great diversity of opinion obtains among leading gynecologists as to the frequency with which abdominal drainage should be used and the length of time the tube should be left in. The more strictly antisepsis is carried out during operations the less drainage becomes necessary, and the absorbent power of the peritoneum may to a great extent be relied upon to remove blood and serum from the abdominal cavity. H. Bloodletting. — Leeches, from two to four in number, may be applied through Fergusson's speculum to the vaginal portion. In order to prevent them from entering the uterus a small cotton plug should be placed in the cervical canal. This method is little used here. The artificial leech may be substituted with advantage (Fig. 1 72). Fig. 172. Reese's Uterine Leech. It consists of a glass cylinder with scale. By pressure on the plate, A, a lance-shaped knife is pushed into the tissue of the cervix to a depth regulated by screwing the disc, I, along the piston, B, and then withdrawn. By pulling the piston out a vacuum is created, into which the blood enter.s. The metal fitting, C, can be unscrewed, so as to allow the removal of the piston and the cleaning of the tube. Scarification. — In most cases no sucking apparatus is needed. A small spear (Fig. 1 73) is pushed to the depth of three-quarters of an Fig. 173. Garrigues' uterine scarifier: a, spear; b, button and side slot; c, main slot; d, shaft. inch into the vaginal portion in three or four places, and blood to the amount of from htdf an ounce to two ounces is withdrawn twice a week. Fig. 173 represents such an instrument, wliicii finds room in a pocket-case, the needle being pushed forward and TREATMENT IN GENERAL. 195 fastened like a bayonet. The posterior lip is less sensitive than the anterior. If the flow does not stop of itself, the small openings are pressed together with a pledget of cotton dipped into cold water, or if that does not suffice, liquor ferri is applied, or a hot douche is administered. Bloodletting is a very valuable remedy in cases of chronic conges- tion, not only of the uterus, but also of other pelvic organs. It has great power to relieve ]>ain. I. Heat and Cold. — We have spoken above of hot, lukewarm, and cold injections (pp. 175-180 and 186). Heat is applied to the abdomen in the shape of a flaxseed-meal poultice or a rubber bag filled with hot water or a double sheet of flannel wrung out of hot water. Sometimes the anodyne effect of such a stupe or fomentation is increased by sprinkling it with oil of turpentine or laudanum. These warm fomentations must be covered with some waterproof material, such as oiled muslin, Fig. 174. rubber sheeting, enamel (/. c. thin oilcloth). Spon- giopiline is felt covered with guttii-percha, and is merely wrung out of hot water. Aiifij)/ilo(/i.sti)ie is a putty-like combination of glycerine, boric acid, salicylic acid, iron carbonate, peppermint, gaulthe- ria, eucalyptus, iodine, and dehydrated silicate of aluminum and magnesium, which is warmed and smeared in a layer i of an inch thick directly on the skin, covered with a cheese-cloth jacket or bandage, and left in place for twenty-four hours. Poultices or a small rubber l)ag with hot water may also be used in the vagina. In acute inflammation an icc-haf/ or a coil with running ice-water is a more expeditious remedy, and checks in most cases the pain more efficaciously. Ff)ur layers of muslin should be inserted b(>tween the ice-bag and the skin in order to avoid local freezing. When the acute stage is ])assed, J*i'irssnitz\'< com- press — /. e. a towel wrung out of cold water and covered with some waterproof material and held in j)lace with a flannel binder — is ])rererable to both hot and cold applications. It is changed every six hours and becomes warm in a few minutes. This change from cold to heat is a ]>owerfnl absorbent. A great variety of hdf/i.s may l)c used as valu:ibl(> adjuvants in gynecological diseases. Tiu; effect on the pelvic organs may be enlianced by the uso. of a hath-sjicmhim (I^ig. 174), which is intro- <liic('d into the vagina and allows the water to fill the same. A tc\m\ (p'n<r<d hafJi^i)^ ix temperature slightly below blood-heat, taken Batli-spcculiiin. 196 DISEASES OF WOMEN. for fifteen or twenty minutes twice a week, keeps not only the skin in good order, but has a marked soothing influence on irritated nerves. Sitz-baths of similar temperature may be taken for ten minutes once a day. 'Turkish and liussian baths may sometimes be substituted for warm baths, but are often too irritating or too fatiguing. An artificial steam-bath may be improvised by placing an alcohol lamp under a chair and an open umbrella partly over the chair and partly over the patient lying in bed, and covering all well with blankets and waterproofs. If the patient is well enough, she may sit on the chair covered with a waterproof. Perspiration may also be induced by the hot pack. The patient is wrapped up tightly to the neck in a blanket wrung out of hot water, and covered with several layers of dry blankets. Perspiration should not be allowed longer than from half an hour to two hours. Sea-baths are often very beneficial as a nerve tonic and to check a disposition to hemorrhage and leucorrhea. A complete hydrothera- peutic treatment may also do good. On a smaller scale cold water may be used to great advantage in the shape of shower-baths, sponge- baths, the wet sheet, or towel-baths. For a sponge-bath the patient stands in a tub and has a pailful of cold water standing at her side — the contents of which she presses all over her body with a large sponge. For a sheet-bath a sheet is dipped into a pail of cold water and thrown from behind over the patient, who is rubbed with it for sev- eral minutes all over the body. Thereafter the wet sheet is exchanged for a dry warm one and the rubbing repeated until she is dry all over. The towel-bath is less powerful, but by no means without effect, in keeping the skin in order, strengthening the nerves, and brightening the mind. It has the advantage that no help is needed for its admin- ' istration. For this three Turkisli towels and a large basinful of cold water will suffice. The patient immerses one of the towels in the water, presses it a little, and washes the upper half of her body with it. Then she dries herself with the two other towels, and finally she repeats the procedure on the lower half of the body, except the feet, which in most people are treated to greater advantage with warm foot-baths. Some European springs enjoy a particular reputation for their sup- posed effect on female comi)laints, such as Franzensbad and IMarien- bad in Austria, Ems and Kreuznach in Germany, and Plombieres in France ; but it would be a grave mistake to think that any watering- place can be more than an adjuvant in the proper treatment of diseases of women. J. Counter-irritation. — Tincture of iodine is often painted once a day on the skin over a swelling in the deeper parts. When the epi- TREATMENT IN GENERAL. 197 dermis is hardened a little, it is well, in order to avoid cracking, to cover it with a compress soaked in the following wash : ^. Acid, carbol, ITlxl ; Glyeerini, 5ss ; Aquse, q. s. ad siv. This allows one to coutiime the use of the iodine indefinitely. (Compare p. 174.) Spanish fly blisters are sometimes used on the abdomen to combat inflammation in the deeper parts. A large blister is a painful remedy, and it has appeared doubtful to mo if it is any better than other means ; but half a dozen small blisters, 2-4 square inches, one of which is put on every evening, often relieve pain in chronic cases. K. tapping and Aspiraiion. — The difference between these two operations is only that in simple tapping a fluid is given outlet through the canula of a trocar by pressure from behind, and in asjM- ration by forming a vacuum in front ; but on account of the greater efficacy of the latter method a smaller trocar, or even a needle, may be used instead of the large trocar used in sim])le tapping. The object is to remove a fluid collected in a normal cavity or a cyst. Tapping is used much less no\v-a-days as a se})arate and complete gynecological operation than a decade or two ago. Tumors are sel- d(jm tapped, the more radicjil operation of removal being ])referred ; but ascitic fluid has often to be evacuated by tapi)ing. Tapping is used during ovariotomy to diminish the cyst, and aspiration is often used as part of a more comprehensive o])eration — e.g. in removing a pyosalj)inx or opening a pelvic abscess. Asjiiratioii through the vagi- nal roof is used to remove encysted peritonitic exudation or a collec- tion of pus in the parametrium. Straight and curved, fine and large, trocars or needles may l)e needed. We have already spoken of the use of the aspirator for diagnostic purj)oses (p. 3G9). A ])atient who is going to be ta])j)e(l through the abdominal wall should sit on a chair or lie on her side with the abdomen turned to- ward the o])erator. The abdomen should be surroinided above and below the point selected for the o])eration with a sheet, the ends of which are crossed in front and pulled upon during evacuation. The <)l)je(;t thereof is not only to ])roduce the necessary jiressure for the evacuation, but to avoid a sudden suction of blood (o the abdominal viscera, which might cause syncope. A quarter of a grain of cocaine sliould be injected with a hyjXKlcrmic syringe into the skin at the place selected, which, as a rule, should be in the mesial line, nn'dwav l)etween the symphysis jmd the umbilicus. Full antiseptic |)rec;ui- ti(»ns should be used. The bladder should be emptied with the ciuheter. The trocar is thrust in, the stylet withdrawn, and the fluid directed into a pail placed on the floor. When all has been removed, 198 DISEASES OF WOMEN. tlio abdominal wall is lifted in a fold around the canula, the latter is withdrawn, the opening is compressed from side to side, and a piece of rubber adhesive plaster placed over it. In the vagina only the aspirator should be used. So far as possible, the puncture should be made behind the uterus. In front is the bladder and to the sides are the uterine artery and the ureter. The latter organs may, however, sometimes be felt and avoided. Tapping has occasionally proved fatal by lesion of a blood-vessel in the abdomen. Septicemia may be avoided by antiseptic precau- tions. Sometimes the canula is left in as a drainage-tube, and has for that purpose two holes or rings for the insertion of cords or wire. The puncture may be followed by incision or dilatation ; then the pointed stylet is withdrawn, and a blunt guide with a longitudinal furrow Fig. 175. Trocar, composed of canula with cap, pointed stylet, and blunt stall'. substituted. The canula is withdrawn and a knife is slid along the furrow in the guide (Fig. 175). F'lG. 17(). Garrigues' blunt expanding perforator. Instead of this method it will in most cases bo found preferable to use a perforating dilator (Fig. 176), sometimes followed by a TREATMENT IN GENERAL. 199 blunt expanding dilator (Fig. 177), and to drain by means of iodo- form gauze or a soft-rubber tube. Fig. 177. Blunt Expanding Pelvic Dilator. L. Abdominal Belts. — An elastic abdominal belt (Fig. 178) is often useful, especially in fat women, to take off some of the pressure on the pelvic organs, and is used during the first three months after laparotomy to take off the strain on the cicatrix. Fig. 178. Teufel's ab porter. When a special pressure above the symphysis is required, an ali- dominal sup))()rter, with a solid hy])()gastric j)a<l, is used. A good ap- paratus of this class is the so-called natural body brace' (Fig. 17J)). M. 3fasH(u/e. — Certain manipulations inside of tiie ]>elvis and through the abdominal walls constitute a valuable mode ol" treatment in many diseases of wouk-ii, especially chronic metrilis, cellulitis, peritonitic exudations, adhesions, hematoma, and (Mjphoritis. ( )f"teii a general massage of other parts of the body or the whole body is added. In this way exudations, infiltrations, liy|)ertrophies, nnd adhesions are made; to disa|)])ear, weak ligaments and muscles strengthened, and disj)laced organs brought bark and kept in (lieir normal positicm. The j)roeednres being rather ])ainful, tliere is no danger of causing sexual excitement. ( )ne or two fingers are inserted ' Natural I'ody I'race Company, National Hotel I'luek, Salina, ]\a. 200 DISEASES OF WOMEN. into the vagina and kept pressed against the part to be massaged, while the otlier liand seizes it throngh the abdominal wall and rubs and squeezes it. This is done for ten minutes three times a week.' If blood or pus has accumulated in the Fallopian tube, massage Fig. 179. Nickel-i)lated, perforated hypogastric pad, forming part ot the "natural body brace." is contraindicated, as there is danger of the fluid being pressed into the peritoneal cavity. N. (ri/mnastics. — The Swedish movement cure may be a valual)lc adjuvant, combined with other methods, and even common gymnas- ^ The limits of this work forbid me even to give an outline of tlie different mani- pulations used in massage. Those interested in it are referred to the ji;iper by A. Reeves Jackson, of ('hicago, on "Uterine Massage as a Means of Treating certain Forms of Enlargement of the Womb," Trans. Amer. Gym. Soc, 1880, vol. v. j). 80; to that by H. J. Boldt of New York, on the " Manual Treatment in Gynecology," Amer. .Tour. Ohst., June, 1887, vol. xxii. p. 579 ; to that by H. X. Vineberg on '' The Treatment of Retrodisplacements of the Uterus with Adhesions by Brandt's Method," N. Y. Med. Record, July 11, 1891 ; and to Profanter's pamphlet, Die Maxsar/e in der Gynakolor/ie, Vienna, 1887. The application of massage in diseases of women is due to Thure Brandt, a Swedish layman, and the method is known under his name. TREATMENT IN GENERAL. 201 tic exercises, if not too violent, are not only an excellent preventive of pelvic diseases, but may be used to advantage toward the end of a cure begun on other lines.' Bicycling is contraindicated in pelvic disease, but is an excellent exercise for healthy women or those afflicted with anemia, nervous- ness or dyspepsia.^ O. Opei-ations in General. — 1. Time for operating. If we have a choice, opemtions should be avoided in this climate during the hot season. It is no small discomfort for the patient to lie in bed for weeks, when not even the nights bring coolness, and it is rather trying for the operator to work when the thermometer is in the nineties in the shade. But I have had hospital-service during the hottest time of the year, and performed both laparotomies and plastic operations without the slightest disturbing influence on perfect success. In general, operations should not be performed on pregnant icomen, on account of the danger of ]>roducing miscarriage. It would seem that interference with the rectum is particularly liable to have this effect. As to the genitals, we may say that the farther the seat of operation is removed from the uterus the less is the danger of pro- voking abortion. Sometimes the very presence of pregnancy may call for operative interference. Vomiting in pregnancy, which may lead to the patient's death, may })e treated successfully by apj)lying nitrate of silver in sul)Stance or in solution to a granular os, or by stretching the os and lower part of the cervical canal (CopehiruVs method) with the index-finger. Large polypi hanging from the cervix may be the source of hemorrhage or become an obstruction during labor. It niay, therefore, be wise to remove them with the galvano- caustic wire. Ovarian cysts should be removed if discovered early. If pregnancy is far advanced, or labor has commenced, ta])ping may 1)0 j)referable. If a cancer of the cervix can be removed, it is better to do so even with the risk of causing abortion, as the cancer, as a rule, grows ra])i(lly during pregnancy, and may cause an obstruction during laixtr that may cost the life of both mother and child.' As a rule, we avoid operations during or near menfttruaiion, on account of the great cong(>stion of the pelvic organs. As the re- moval of the ovaries, or j)rol)ably rather the tying of the pedicle, very commonly brings on a l)U)o<ly flow, even if the ])atient has just gone through her menstrual jx-riod fp. 121), it may, however, be pr('f('ral)le in anemic ])atients, in order to avoid this extra loss of blood, to operate immediately before or during menstruation. ' llie value of pymimstics as prevent ivi; of and cure for ])elvic disorders lias lieen inciilcate<l hy .loliii" H. Keliotrp, .W'<l. Nnr.-<, Noveiuher S, 1890. No. '.»:50, p. JOS. ' (larrimies, '" Woriiati and the IJicvcle," Tlir Forum, .Jan., IH'Ji), pp. 578-r)S7. " Further information may he found in a ])aper hy M. I). Mann of Bufliilo, N. Y. : "Surj,n(!il Operations on the Pelvic Organs of Pregnant Women," Traim, Amcr. (Jyn. Soc, 1882, vol. vii. p. ;}40. 202 DISEASES OF WOMEN. For ovariotomy the presence of menstruation is of no importance. In oases of myomectomy and hysterectomy it is better to avoid the period. PhL-^tic operations ought always to be performed shortly after menstruation, as the occurrence of this flow might be mistaken for hemorrhage or interfere with proper after-treatment. Lactation need not interfere with operations. It is only necessary to discontinue nursing for twenty-four hours, on account of the effect of the anesthetic on the child, and press or pump out the milk of the breasts. The time of day most suitable for serious operations is the morn- ing, when the operator may be sure not to have come near any case from which pathogenic germs might be brought to the patient, and his own nerves are refreshed by rest and sleep. But other considera- tions often prevail, and many operate in the afternoon. Day-time should always be preferred, as no artificial light can replace good daylight. If it is necessary to operate, at night, care should be taken to obtain as perfect an illumination as possible. The electric light and gas-jets with Welsbach hoods are the best. 2. Preparation for Operations. — The more thought the operator and his assistants bestow beforehand on every detail of a contem- plated operation, the more smoothly it will come oflP, and, other things being equal, the better the result will be. Boom. — If we have the choice, we should select a large room with a good light for operating, and, if possible, this should be another than the one in which the patient shall lie after the opera- tion, but contiguous with it. The best room should be reserved for the after-treatment. According to the season this should either be cool or have a southern exposure. For an important operation, especially a laparotomy, all superfluous furniture should be removed, the carpet should be taken up, the bedding aired, the floor and, if they are oil- painted, also the walls should be scrubbed, not only with soap and water, but thereafter with a solution of bichloride of mercury (1 : 1000). No curtains should be allowed round the bedstead. Every object should be carefully dusted. The room should be pleas- antly M'arm, about 70° F., or, if the abdominal cavity is to be opened, even a little more than that. The bed should have a horse-hair mattress and blankets. If possi- ble, it is a great advantage to have two beds. With proper precau- tions even a very sick patient may be moved from one bed to another, and it contributes much to her comfort. Table. — A strong narrow table should be placed with one end in front of a window. A common kitchen table four feet long and two wide is very convenient. It should be covered with a folded blanket or quilt, a muslin sheet, and a rubber sheet or oil-cloth. The latter TREATMENT IN GENERAL. 203 should be pinned together, so as to form a funnel leading at the lower end of the table down into a pail. Instead of the latter arrange- FiG. ISO. Inflatable Surgical Rubber Cushions.* nient inflatable rubber cushions (Fig. 180) may be used to advantage. A towel or sheet may be rolled so as to form a hard cylinder, -which is bent so as to form part of a circle or tiie three sides of a square, and in the latter case tied with strings at the corners. This frame is covered with a rubber sheet. Tlie first i)art of tliis arrangement may be improvised, and the latter is easily carried in a satchel. A pillow is j)laced at the head of the table, and this end is slightly raised so that fluids may gravitate down into the ])ail. For laparotomy it is better to have the table level with drainage to the side where the operator stands or under the table. In hos])itals, tables are preferably used that can be thcM'oughly disinfected. Good tables for this ])urp()se, and Avith facility for elevated-pelvis ])osition fp. 140), have been constructed l)y Cleve- land, f^dcbohls, Foerster, and lioldt. Leopold uses for the elevation of the pelvis an apparatus that has the advantage of being inexpensive and so simple that any carjK'utcr can make it. It consists of a frame 50 inches long and 20 inches wide, with a hinged flap that can be raised. The shorter, lower part of the flap, uj)on which the legs rest, can be bent downward, so as to form a right angle with the up])er part, upon which lie the thighs and the jx'lvis, and which is a yard lon<r. I>y means of a sup]K»rt the flap can be raised as much as 20 inches above the frame, so that tlie sujjport forms an angle of about '>0° with the upjier ])art ' DescriiKid by Howard Kelly, Amer. Jour. Oh."/. 1SS7, vol. xx. p. lOI'.O, l.iif II. <). Marey of lioston claims many years' priority {Tnins. Aiiicr. Ax.wridlioji af l)hxlfln- ciann and Gynecylo(jixls, ]89.'5, reprint, p. 13). 204 DISEASES OF WOMEN. of the flap. The frame is fastened with iron clamps to a table (Fig. 181). MoNaughton ' has had made of galvanized iron a portable attach- ment that also can be nsed on common kitchen tables. In hospitals two long wooden foot-stools, about six inches high, should be in readiness to be nsed when the patient is brought into the elevated- pelvis position. A fairly good apparatus for the elevated-pelvis position may be improvised by placing the patient on the back of a chair. It should be properly padded and the patient's legs tied to it (Fig. 182). Assistants. — For most operations three, four, or even five assist- ants are needed, and each of them should have his part distinctly Fig. 181. Elevated-pelvis position (Leopold's apparatus): «, adjustable flap; 6, supporter: c, wooden frame fastened with clamps to table. allotted and explained to him beforehand. One should be in charge of the anesthesia exclusively ; and as the patient's life in most cases depends mucii more on him than on the oj)erator, this function should be confided to the most experienced ])er.son available. In operations with the patient in the lithotomy position one assistant should hold either knee under his axilla, thus keeping both hands free for sponging, holding speculum or tenaculum, or for such other assistance as may be needed. If a leg-holder is used (see below), in simpler operations, such as curetting, only one assi.stant is needed. ' McXaujjliton's attachment is sold by 11. A. Kaysan, 36 Bond .street, Brooklyn, N. Y., for $12.00. TREATMENT IN GENERAL. 205 In laparotomies one stands opposite the operator and the other at his left. A fourth assistant may be used to hand instruments, which saves time and allows the operator to keep his eyes uninterruptedly on the field of operation ; but in order to limit the possible sources of infection as much as possible, some operators prefer to place their instruments within reach and dispense with this assistant. As a rule, the assistance of a nurse is required to hand gauze, sponges, and attend to fluids, basins, pitchers, syringes, dressing-material, etc. Spectators. — There can hardly be any doubt that the fewer persons present in the operating-room, the better, other things being equal, are the chances of the patient. Particularly in laparotomies the presence of persons coming from a case of erysipelas, scarlet fever, Fig. 182. Elevation of nulvis bv iiu'iuis of a fhair. diphtheria, or other zymotic disease constitutes an element of danger. On the other hand, nolxxly can learn to operate by reading descrip- tions of operations. The; accumulated exi)erienc(^ of mankind in this line can only be accjuired by seeing others at work. And it is, therefore, in the interest of humanity in general that operators admit students and fellow-practitioners to witness their operations. To what extent and with what restrictions this should i)e done depends on many circumstances which cannot Ix; considered her(\ Kx[)erinients have shown that by loud talking and still more by coughing and sneezing minute drops of the secretion of the mouth and nose mav be carried to a distance of several vards, and there cause 20G DISEASES OF WOMEN. infection by bacteria contained in those secretions, which is a serious matter, since entirely healthy persons frequently have staphylococci and streptococci of complete virulence in their mouths.^ Patient. — The patient's urine shoilld be examined witU special reference to the presence of albumin in the same, as it may be deemed necessary to postpone the operation or desist from it alto- g:ether, if the kidneys are in a bad condition, or, at least, to prefer chloroform to ether as an anesthetic, the latter having ])roved partic- ularly dangerous in patients with inflamed kidneys,^ or to use opium or cocaine, or operate without an anesthetic. If there is albumin in the urine, it should also be examined miscroscopically for casts. If there is an excess of pigment and salts in the urine, it is well to pre- pare the patient for an importiint operation by the use of Vichy, or lithia, or Poland water. If the urine contains sugar, the patient would not be a fit subject for any plastic operation until she had. been properly treated for glycosuria. The presence of pus or many epithelial cells may likewise call for special preparatory treatment before an operation is undertaken. The heart and the lungs should also be examined. If the heart is diseased, chloroform is particularly dangerous. Advanced phthisis is a contraindication for nearly all operations ; in lighter pulmonary affections ether should be avoided. On the day preceding that of the operation the patient should have a warm bath and be scrubbed with soap all over, in order to have the skin in as good a condition as possible. In order to loosen old epidermis-cells and kill microbes still more effectively, it is M'ell, before laparotomies, to apply a poultice of potassa soap to the abdo- men for twelve hours ; then to wash the skin with water and with alcohol, and finally to apply for another twelve hours a bichloride of mercury poultice (1 : 2000) covered with rubber sheeting and held in place with a bandage. To move her bowels she should toward evening take a heaping teaspoonful of compound liquorice powder or another suitable aperient, and after that she should receive no other food than a little coffee or beef tea. Six hours before the operation she should be given an enema of a quart of soap-suds. Twenty minutes before anestliesia is begun I give a hypodermic injection of ^ of a grain of morphine and -^^ of a grain of sulphate of atropine, the first of which has the effect to diminish the amount of the anesthetic needed, and the second strengthens the heart. In timid patients this administration of narcotics may even be con- ducive to safety by tranquillizing the nervous system. »C. Flucrge, "Ueber Luftinfektion," Cevtralbl.f. Gmak:, 1898, vol. xxii, p. 350. 'T. A. P^mmet, /. c, p. 745. Some later observers claim, however, that chloro- form is still worse than ether when the kidneys are affected (see Anesthesia). TREATMENT IN GENERAL. 207 Immediately before the operation begins, the bladder should be emptied with the catheter, even if the patient says she has just urinated. The patient should be in night-dress, and the feet, legs, and thighs covered with leggings made of a woollen or other warm stuff. In private practice stockings are sufficient. Besides, she should be covered with a sheet and towels in such a way as never to expose more of her body than needed to give access to the field of opera- tion. For abdominal operations, the skin should be shaved, scrubbed with tinctura saponis viridis and plenty of water, then washed with alcohol and bichoride of mercury (1 : 2000). The field is surrounded with four sterilized towels pinned together and to the clothes. Even in laparotomies the genitals should be Clover's Crutch. shaved and disinfected, and the vagina carefully disinfected by swabl)ing with tinctura saj)ouis viridis, followed by corrosive-subli- mate solution, and thereafter lysol (1 ])er cent.), in order to counter- act the roughness left by the corrosive-sublimate. lM)r operations of the external genitals, similar ]>r(>cautions are taken and the but- tocks are covered with a large j)iece of sterilized gauze in which a hole is cut in front of the vulva. For perineal and vaginal operations the knees are lifted more or h'ss uj), and kej)t sepanite bv means oi' C/orrr^s cnifc/i ( I"'ig. ls;|), :in 208 DISEASES OF WOMEN. expensive apparatus which, however, may easily be replaced at small cost by placing a two-feet-long broomstick in the popliteal spaces, tying it with some figure-of-eight turns to each knee with a roller- bandage, and leading part of the bandage up behind the neck of the patient. An inexpensive leg-holder is that of Robb (Fig. 184). It is easily Robb's Leg-holder. rolled up, and takes up little room in the satchel. It surrounds the lower part of the thigh, passes under the right shoulder and above the left, which is protected against pressure by a thick pad of cotton batting being placed between it and the leg-holder. I have, however, seen several cases of semi-paralysis, numbness, and pain in the arm or leg follow its use. But similar effects are observed with other apparatus. Good operating-tables have special uprights with stir- rups, to which the feet are attached in an elevated position. Anesthetists should pay much more attention than is usually done to the prevention of that more or less complete paralysis that may follow an operation. Anesthesia parali/sis may be of central or peripheral origin. The former is very rare and is due to cerebral apoplexy or to eml)oli or softening of the brain. It takes the form of hemiplegia or hemiparesis, and probably some cases of so-called ether or chloroform death are caused by it. The peripheral form is more frequent and is always due to pressure, either on single nerves, such as the musculo-spiral at the lower end of the deltoid muscle, or on the brachial plexus, the pressure occurring between the clavicle and the anterior surface of the first rib. This pressure is a])t to take place when the arm is elevated alongside of the head or TREATMENT IN GENERAL. 209 brought out from the body. In most cases of periplieral paralysis the prognosis is good, but it may take many months or even years before a cure is effected. Pressure on the special nerves should be avoided, and the arms should never be raised above the head, but, as far as possible, placed in an easy position on the chest. In using leg-holders, the parts exposed to pressure should be carefully padded with cotton batting. The head should be supported on a pillow, and if the patient vomits, and the arm is raised, the head should be bent toward the arm, and not away from it. In regard to curative treatment, faradization is best of all, but massage, strychnine, and hydrotherapy may also answer a good purpose.^ Vessels and Towels. — Two instrument trays of hard rubber, enam- elled iron, china, or glass should be kept ready, likewise 4 plates for ligatures, sutures, iodoform gauze, and gutta-percha tissue ; 4 basins ; 4 pitchers, with hot water, cold water, carbolized water (5 per cent.), solution of bichloride of mercury (1 : 1000); 2 fountain syringes or douche-cans, with a straight glass nozzle 6 inches long, and a hard- rubber nozzle with a stopcock easily opened and closed with the thumb (Fig. 185). At least a dozen towels will be needed. Disinfection, Asepsis, and Antisepsis. — In hospitals and so far as possible in private practice operations should be performed according to the rules of aseptic surgery, but in private practice this is some- times not feasible, and then a high degree of safety is still obtainable by strict adherence to antiseptic measures. Common to both sys- tems is the disinfection of the room, the field of operation, the ope- rator and his assistants. In aseptic surgery the disinfectant agent Fig. 185. Xozzle with Stopcock. relied on is heat in the shape of boiling water or moving steam ; in its antiseptic forerunner the same is aimed at by means of chemicals that possess germicidal power. In the instrument-stores arc found more or less costly apj)aratus for rendering instruments, gauze pads, towels, coats, etc., a.sej)tic, but the same may be obtained at small exj)ense by using utensils that are on the market for other purposes. Thus, an agate-ware asparagus-boiler is an excellent instrument-boiler, and a large-sized Arnold milk sterilizer can be used for gauze, towels, etc. Instruments are boiled for live minutes in a solution of crudt; ' H. J. (Jarrigufs, " Anesthesiii Paralysis," Aiwr. Jdhv. Mnl. Sri., .Jan., IS'.iT. 14 210 DISEASES OF WOMEN. carbonate of sodium, that is, common washing soda — a tablespoon- ful to the quart. Even cutting and pricking instruments are disin- fected in this Avay, but shouhl be wrapped up in gauze so as not to be mechanically injured. Gauze, towels, and other material are disinfected by having a current of steam circulate through them for an hour. We have already referred to the disinfection of the room and the field of operation. The operator and his assistants take off their coats, turn up their sleeves to the elbow, scrub their hands and fore- arms with potassa soap and hot water, using a rather stiff nail-brush, wipe their hands, remove all dirt from under the nails with a steel nail-scraper, and scrub the hands in a solution of bichloride of mer- cury (1 : 2000) for at least three minutes, after which they should not wipe the hands. To combine the use of soap and corrosive sub- limate in disinfecting the hands is wrong, as the soap deprives the drug of some of its power. On the other hand, disinfection is much improved by immersing the hands in alcohol or "washing them with the same for five minutes before rinsing them in bichloride solution. Rubbing the hands with equal parts of chlorinated lime and car- bonate of potassium, by which chlorine gas is generated, adding M'ater enough to form a paste, may to great advantage be made part of the disinfection between the use of soap and alcohol. It is con- venient to put on a rubber apron covering the whole front of the body from tiie neck down to a little above the feet, and to pin to this a towel wrung out of carbolized water, or sterilized, or, still better, to put on a sterilized coat and cap. Some operators cover their hands with disinfected gloves. To use cotton gloves for the surpose seems nugatory, when we take into consideration the com- parative size of microbes and the meshes of woven tissue. Much more rational is the use of fine rubber gloves, l)ut it is a question whether the loss in delicacy of touch does not counterbalance the advantage of keeping back the few bacteria that have resisted the disinfection of the hands. On the other hand, the advice to use a separate knife for incision of the skin only, is excellent and deserves general adoption, since there is no means of reaching the microbes located in the deeper parts of the glands of the skin.^ For dressing, the antiseptic materials, such as iodoform gauze or corrosive-sublimate gauze, sold by druggists and instrument-makers, may be used, but much of so-called aseptic ligatiu-e and suture material and sponges found on the market is unreliablo.- Entirely reliable sterile suture material — plain and chromicized ' Dr. Carl Beck, "On Some Important Points Regardinj; Perfection of Asepsis,'' Kew York Med. Recnnl, Oct. 7, 1899, vol. Ivi., No. lo, p. oOo. * Aseptic material may Ije prepared in many ways ; I describe only tlie one I follow myself. TREATMENT IN GENERAL. 211 catgut, silk, silkworm gut, and horseliair — is prepared by Geo. St. John Leavens, 72 Bible House, New York. It comes in sealed glass tubes, and is sterilized by boiling in absolute alcohol at 250° Fahr. for forty-five minutes after sealing. At the time of ope- rating, the tubes are broken (Fig. 186). If catgut is used, it must be immersed in sterilized Avatcr in a sterilized tray for a few minutes, in order to make it pliable. Leavens' Suture-tubes : A, sterilized at 25(P F. after sealing ; B, opened at operation. Sponges. — The raw sponges are beaten in order to soften them and remove sand, and then immersed in acidulated water (acid, hydro- chlor. .Ij to each quart of water) in order to di.ssolve the calcareous matter. Part of this trouble may be avoided by buying the sponges already pre])ared ; but even then they have to be treated with the acidulated water, and wrung many times out of water until all sand has been removed. When sponges have l)een used in an operation, they are cleaned in the following way : They are first washed with soap and water until the water remains clean ; then they are left for an hour in a solution of jwtassa (liqu(jr. potassa> 5J to each quart of water) whicii draws out all the blood. If the sponges have been unusually soaked in blood, it may become necessary to change this solution. Then they are again wrung out of plain water till it stays clear. After that they are left lor an hour in a solution of bichloride of mercury (1 : 1000), wrung out, drii^d in the sun or in front of a fire, and kept in a muslin bag. By kee])ing them in this dry way th(y do not be- come rotten so soon as when kept in an antiseptic fluid. Jiefore using th(.'iu the next time th(y are left for five or ten mimites in a sirnilar solution of bichloride, after having soaked them well i)v pressing all the air out of them, wrung out, and kept in cMrliolizcd 212 DISEASES OF WOMEN. water (2 or 2^ per cent.) or plain boiled water during the opera- tion. Three sizes of sponges are needed: small round about 1^ inches in diameter ; large round, about 3 inches in diameter ; and large flat sponges, ^ inch thick. Most operators, in order to avoid infection from sponges or the trouble of disinfecting them, have discarded them altogether, and use, iustead of round sponges, small pads of sterilized gauze or round balls of absorbent cotton wound with gauze, and instead of the flat sponges pads of several layers of gauze, about 8 by 6 inches. Such gauze sponges are sterilized with heat in Arnold's milk-sterilizer or some other apparatus through which steam circulates. Silk. — Twisted or braided silk is used : the latter is stronger. Four thickne&ses are needed: Nos. 1, 2, 5, and 12 of the braided. In hospitals it is sterilized immediately before each operation by being placed for an hour in the sterilizer. Schimmelbusch of Berlin has constructed a practical metal box for this purpose (Fig. 187). Fig. 187. Schimmelbusch's Metal Box for Sterilizing Silk and Keeping it Sterile: yl.box opened in order to expose the silli to the circulating steam of the sterilizer ; B, partly closed as when in use. Since we have obtained reliable catgut, I have given up using silk for most purposes. It dissolves very slowly, and if it become in- fected, it will cause the formation of fistulous tracts that do not heal until the offending ligature has been removed, which may take weeks or months. At all events no ligature should be made of heavier material than needed ; nor should more of it be used than is required. (htr/ut, so called, is in reality sheep's gut — the strong air- and water-tight layer found between the mucous membrane and the muscular coat of the gut of sheep, being cut in long shreds and twined. It is hard to render it aseptic and keep it so, but its ab- sorbabilitv makes it verv valuable for ligatures and buried sutures. TREATMENT IN GENERAL. 213 A simple and excellent way of preparing it is to boil it an hour in so-called absolute alcohol (97 per cent., or even in the common 95 per cent.) in a closed glass placed in a water-bath, and keep it in the same alcohol.' Fig. 188. Dowd's Apparatus for the Sterilization of Catgut. This method has been made easy, inexpensive, and safe by means of Dowd's condenser, represented in Fig. \Sd>.^ The catgut is wound on glass reels enclosed in small glass jars, which are immersed in alcohol in a larger jar j)laced in a water-bath on a gas-stove. From the top of the large jar the vapor of the boiling alcohol rises into a coil of tin, in which it is condensed by having cold water flowing through the surrounding copper cylinder, and from which it drops back into the jar below. For hospital use tiie catgut may simply be l)<»iled in a common fruit-jar with ak'ohol, witii the metal t(»p screwed tight and standing in a casserole with water during the j)rc- paration for the operation. ' CJeorge K. Fowler of lirooklvn, N. Y. ^f^•(^. Rcrnrd, 1890, vol. .\.x.\viii., \>. ITS. ' Charles N. Dowd, of New York, Mai Record, Dec. 3, 1892. 214 DISEASES OF WOMEN. Another excellent way of disinfecting catgut — Reverdin's method — is by means of dry heat. For this purpose an ov'en with double copper walls covered with a layer of asbestos is needed. The air is heated by means of a Bnnsen gas-lamp, and an automatic arrange- ment regulates the gas supply, so as to avoid overheating, which makes the catgut brittle. The catgut is rolled in small hanks like violin cords, placed in test-tubes, which are closed with cotton and placed in the oven. For an hour, the heat should only be 70-80° C. in order to drive all moisture out of the catgut, which otherwise is changed to glue and becomes unfit for use, and thereafter it is ex- posed for two hours to a temperature of 130° C. Immediately before use, it is immersed in hot boiled water in order to make it pliable. A modification of this method is to use wide-mouthed vials with glass stoppers, instead of test-tubes, take the stoppers off while the catgut is heated, and to keep the catgut in absolute alcohol to which is added yfoT ^^' corrosive sublimate. By the same method chromicized catgut that is slow to absorb may be obtained — Doderlein's method.^ The catgut is immersed for ten minutes in a solution of chromic acid (1 : 10,000), and then dried and heated in test-tubes, as described above. This catgut withstands absorption for over four weeks. A tube that once has been opened cannot be used again. A third, very simple and inexpensive method of disinfecting cat- gut is by means of formalin, that is, a 40 per cent, solution of for- malhyde — Kossmann's method. The raw catgut is wound on glass spools and immersed for twenty-four hours in a 2 per cent, solu- tion of formalin — 1 part of the commercial formalin to 20 parts of water. In order to avoid the irritation caused by the chemical, and at the same time to avoid swelling of the catgut the spools are washed with normal salt solution according to the formula : — sodium chloride 7.5, sodium carbonate 2.5, and distilled water 1000. The spools are shaken lightly, changing the solution two or three times. The catgut thus prepared is kept in glass vials with the same salt solution. It may also be kept in a dry state. For this purpose the cat- gut is rolled into hanks, each packed in blotting paper. After im- mersion in formalin solution as ahove stated, each package is pressed between two layers of blotting-])aiier and then ex])osed to moderate dry heat, about 60° C until it is perfectly dry, in which state it keeps indefinitely. Before using it, it is placed for a few minutes in sterile salt solution.^ A fourth and good way of disinfecting catgut is by means of ' Doderlein, Miinchener Medicinische Wochenschrifl, 1890, No. 4. * Kossmann of Berlin, Centrnlhl. f. Gyndh., 1895, vol. xix., No. 20, p. 545, and his assistant, Vollraer, ibid, No. 46, p. 1219. TREATMENT IN GENERAL. 215 cumol — Kroenig's method.' Cumol is a fatty, yellowish fluid found in Roman cumin oil and obtained artificially by distillation of cumic acid. It has a very high boiling-point, between 168 and 178° C. Each catgut thread is wound into a hank with a diameter of four finger-breadths, and the shape of the ring preserved by tying it with a thread in three or four places. The hygroscopic water contained in the catgut is driv^en out by exposure to moderate heat, as stated above, slowly raising the temperature to 70° C. and keeping it there for two hours. Next, the catgut-rings are immersed in a graduate with cumol, two-thirds of which is surrounded by a sand-bath, consisting of an enamelled pot filled with sand, heated to from 155 to 165° C. by two Bunsen burners. The glass containing the cumol is covered with a metal net, in order to avoid the danger of its ignition by the approach of a flame. The catgut is kept in the cumol for an hour. When the cumol has reached a temperature of 155° C, one burner is turned ofl', and then the temperature remains for an hour between 155 and 165° C. The same cumol may be used over and over again. In order to remove the cumol from the catgut, this is seized with a disinfected forceps and placed for three hours in a disinfected goblet witli pe- troleum benzin, and then kept in dis- infected Petri dishes, glass dishes with overlapping covers, in which it keeps aseptic for weeks. This catgut is, ac- cording to its thickness, absorbed in from 7 to 13 days. For the intestine the very finest is required ; but here silk is preferable. For closing the ])eritoneum in lapa- rotomies a somewhat thicker one is ne(Hled ; fi)r the abdominal aponeuroses, ligaments, fiiseifc, the cervix, the vagina and the ])erineum a medium siz(> is used; and i'or the j)e<licles of tumors a very thick one. Diflerent manufac- tuHTs use diflerent mnnbers, so that I cannot designate the size in that way. Whetiier caigut is disinfected in one of these ways or another is of minor importance. The (;hief point is to avoid handling after the disinfection. It should be wound on ' Krocnit,', Lciir/.i^, Centmlhl. f. Gyniik., 1894, vol. xviii., ?.'(). 27, p. G.')0. Glass reels for svitiire ninteriuls, kept in aseptic test-tubes. 216 DISEASES OF WOMEN. glass-reels (Fig. 189) or fashioned into small hanks before disinfect- ing it. At the time of the operation what is needed should be taken out of the vessel in which it is kept, with a disinfected forceps, and never should any spool or hank be replaced in the vessel from which it has been taken. In private practice the surgeon saves himself a good deal of trouble and anxiety by using Leaven's plain and chromicized catgut. Catgut has the advantage over silk that it is soon di&solved and absorbed, which recommends it for ligatures in wounds or cavities from which it cannot be removed, and for sutures in so far as its removal becomes unnecessary. The thick grades are so strong that they never break in being tightened. It has therefore been recom- mended as exclusive material for both ligatures and sutures, while others as exclusively use silk for all purposes. On the other hand, catgut is more difficult to tie, becomes easily untied, so that triple knots are necessary where there is any strain on it, and, as before stated, it is more difficult to render and keep aseptic. Its great dis- solvability proves even sometimes a fault instead of a virtue ; which, however, can be remedied by preparing it wdth chromic acid. Silkworm gut is sold " prepared " in a long bundle tied at both ends. It may be disinfected by boiling it in water for ten minutes, or ex- posing it like silk, for an hour to steam in motion. For most cases the following precautions suffice : as many single threads as are likely to be used are cut off before the operation, washed in a solution of bichloride (1 : 1000), and kept in carbolized water (2 per cent.) or some other disinfectant during it. It is, of all materials, the best for oj)erations on the perineum. It does not absorb fluid like silk, does not become corroded like" catgut, and does not hurt in reijioval like silver wire. Horsehair is an excellent material for many purposes, especially for enterorrhaphy according to Maunsell's method.^ The hair should be taken from a male animal. The longest and strongest hairs without a flaw should \)G selected, tied at one end, brushed up with soap and water. Next they should be immersed in bichloride-of-mercnry solu- tion (1 : 4000) for two or three hours. After that they are shaken out and placed in a large glass-stoppered bottle. Before being used they should be immersed in bichloride solution for several hours, in order to make them pliable. Kangaroo tendon shares with catgut the advantage of being absorb- able, and resists absorption for a longer time, which makes it particu- larly valuable for certain operations, such as radical hernia operations, but its high price is in the way of a general use of it. Silver Wire. — Silver wire is made aseptic like instrimicnts by boiling in a solution of carbonate of sodium (p. 209) or by drawing ' Maunsell, Amer. Jour. Med. Sci. March, 1892. (See Appendix.) TREATMENT IN GENERAL. 217 it through the flame of an alcohol lamp, and is kept during the operation in carbolized water or alcohol. The thicknesses commonly used are No. 26 for the perineum, Xo. 27 for the cervix, and No. 28 for the vagina. The thickest of these may also be used for the closure of the abdominal wound in laparotomies. Some prefer it, even, on account of the antiseptic property of silver, but upon the whole it is used much less now than some years ago. Iodoform is not, in itself, an antiseptic; but it seems that it is de- composed by the very appearance of piis-cocci and the formation of ptomaines in such a way as to become a germicide. HoAvever this may be, experience has shown that it is a most valuable preventive of suppuration and sepsis. Its disagreeable odor may be covered by adding 1 part of thymol to 5 parts of iodoform.^ A chemical combination of the two has been introduced under the name of aristol. Coumarin, the oderiferous principle in Tonka beans (1 part to 5), and ground coffee are also recommended for the purpose of covering the smell of iodoform. Iodoform gauze may be disin- fected by placing it in a closed glass jar in the sterilizer for half an hour, its color changes partially to blue by a combination of the iodine and the starch contained in the gauze, but in contact with liv- ing tissue iodoform is reproduced. Antiseptic Fluids. — Bichloride of mercury is a powerful antiseptic, but so poisonous that it has to be used with great circumspection. Experiments have shown how fatal the effect of a solution of bichlo- ride of mercury is when it is kept in contact with a wound leading into the subcutaneous connective tissue, and the same applies, of course, to the submucous. Even the intact mucous membrane of the vagina absorbs it.^ I liave, therefore, nearly entirely discarded it for intra-uterine and vaginal injection and irrigation of wounds or the peritoneal cavity. I use it almost exclusively for washing the skin and the vagina, and for the hands of tlie doctors and nurses. It is convenient to have a solution of 1 : 1000, which may be diluted by adding hot water. Ovrbolic acid is used for instruments and sponges where asepsis is not ol)tainable. It is best to have a 5 per cent, solution, and add hot water so as to get a 2^ or 2 per cent, solution. Creolin forms no solution, but an emulsion, with water. This emulsion should l)e pre])an'd by pouring the creolin into <'old water, stirring it, and adding the same amount of hot water. The strength that answers Ix'st in most cases is a 1 per cent, emulsion (2 table- spoonfuls to .J quarts of water), but both i per cent, and 2 per cent, solutions are used. The enmlsion looks like milk with a little ^MfdWorUl, 1H8G, )). 89. 'Details may he foun<i in my article on "Corrosive Sublimate and ( 'reoliii," Avier. Jour. Med. Set., 1889, vol. xcviii. 218 DISEASES OF WOMEN. coffee. It lias the fault of being opaque and of producing a smart- ing sensation in tlie vagina of some patients. It is not so powerful an antiseptic as bichloride of mercury ; but, compared with carbolic acid, it has the advantage of being an excellent hemostatic, of being almost innocuous, of making the tissue slippery, of having a rather pleasant odor, and of not affecting the operator's skin and nerves. I use it after curetting, especially for cancer, where its hemostatic powers prove of great value. Li/sol has the advantage over creolin of forming a nearly clear mix- ture with water. It is used in the same strength, is slippery, and has a less pungent odor. For injection it has to a great extent replaced the other disinfectants, but it is not suitable for operations, as it be- comes nearly black by mixture with blood, renders tissue and instru- ments too slippery, and foams. Hydro-naphthol is much praised by the few who use it. '^ It is harm- less and does not injure instruments or operator's hands. The strength used is a saturated solution in hot water. The peritoneal cavity may be repeatedly tilled with this solution with perfect impunity." ^ Boro-mlici/lic i^olidion, or Thiersch''^ solution (K : Acidi borici 12, Acidi salicvllci 2, AqUcT 1000), is a bland fluid that likewise may be used in the peritoneum or for irrigation of wounds.^ Thymol (1 : 1000) is also a bland disinfectant. For wetting pads, keeping instruments immersed, irrigating wounds, and cleaning blood-stained hands during operations, ster- ilized water — that is, water that has been boiled for from two to five minutes — is used. It should be prepared fresh daily. .3. Anesthesia. — The two chief anesthetics used are ether and chloroform. Ether, as the safer of the two, should be preferred, except when the lungs, the larynx, or trachea are affected, or in patients suffering from congestion of the brain, for under these cir- cumstances ether is the more dangerous of the two. In regard to the kidneys the most divergent views are entertained. Schleich^ holds that chloroform is particularly dangerous for the kidneys, because on account of its high boiling-point — 149° Fahr. — it can only be eliminated through these and not through the lungs, as ether is. On the other hand, Drs. Wm. H. Thompson and R. C. Kemp, basing their views on their experiments on dogs and rabbits with the onchometer, an instrument which shows the circulation in the kidney, compared with that in the general system, declare that chloroform has no effect on the kidney, while, according to them, ' Clinton Ciishing, Pacific Med. Jour., July, 1890, reprint, p. 7. First recom- mended by Geo. R. Fowler of Brooklyn, X. Y., Sew York Med. Jour., 1885, vol. xiii. p. 374 et ■•^ee/., and endorsed by R. J. Levis of Philadelphia, ibid., p. 593. *A convenient way of making this solution is by dissolving Thiersch's tablets in water, 1 tablet to each quart. •* C. L. Schleich, Schmerzlose Operationen, 3d. ed., Berlin, 1898, p. 60. TREATMENT IN GENERAL. 219 ether is contraindicated in kidney disease, especially albuminuria with tendency to pulmonary edema. Chloroform depresses the heart, which ether strengthens.^ If heart trouble is combined with lung disease, ether is more contraindicated than chloroform. It seems, also, that there are differences of susceptibility to the effect of the two drugs in different persons. I have had cases where one of them, ether as well as chloroform, failed to induce anesthesia, but caused alarming symptoms, such as convulsions or arrest of respiration, while the other worked satisfactorily. I have had one patient who stopped breathing as soon as the first dimming of consciousness began. We tried in vain ether, Schleich's mixture,- A. C E. mixture, and the simultaneous administration of ether and oxygen. Some prefer mixtures of ether and chloroform in different pro- portions, usually combined with absolute alcohol. A combination of this kind is known as the A. C. E. mixture : I^. Alcohol absoluti, 3J ; Chloroformi purificati, .sij ; ^theris fortioris, 5iij. M. S. — A. C. E. mixture for inhaling. Personally I have been much pleased with this mixture.^ A very good method of producing anesthesia is to begin with nitrous oxide gas, and when unconsciousness has been achieved, to continue with ether — the so-called (jdx-dher method. It is verv expeditious, and saves the patient all tiic unpleasantness of getting under the influence of ether. On the other hand, it is said to be particularly dangerous to start witii chloroform and then continue with ether, because when })ar- tially under the infiuenee of chloroform the glottis allows a higher percentage of ether to pass, and if the lung-circulation be slow, as is likely to be the case, the blood may be so highly charged with etiier as to depress rather than to stimulate the heart.' 'Thompson and Kemp, Mi'd. Record, Sept. 3, 1898. 'Chloroform, fi.^iss. ; .'ether petroh-i, .^ss. ; a-tlier sulpluir., ,^vi. This mixture lia.s many excellent qualities (see (iarripues' "Clinical Observations in Keiranl to General Anesthesia by the Schlcich Mixtures," GijnecoL Tnms., 1S9S, vol. xxiii., jip. II0-I27, and Med. Nevn, Nov. \2, '9*^,), l)ut unfortunately it is dangerous, owiny; to its effect on respiration (see (iarrimies, M<<1. Nev.^, .Jan. 7, 1S99). My clinical experience in this respect coincides with the experimental studies of H. C. Wood, Jr.. of Philadelphia, " Benzine in Anesthetic Mixtures," I'liild. Med. Jmn:, April I'), 1H99. "It is much praised by .John C. Reeve, Davton, O. {Tnni.*. .imrr. Gj/iierol. Sor., 1891, vol. xvi., p. 20); and Lawson Tait declares the combination to be a ;:rcat advance over either ether or chloroform iiseii separately {Ihi(f(do Mi<l.-ti\n-<i. ■Jmir.. quoted in Med. Brief, May, 1894, p. G.'JO). *.I. T. Clover, quoted bv II. .J. lioldt, Med. Review of Reviews, April, 1S97, rcjjrint, p. 16. 220 DISEASES OF WOMEN. Both chloroform and ether produce in protracted operations acute nephritis with casts and albuminuria.^ In giving ether, constant watch should be kept on the respiration. As soon as it stops, etherization should be interrupted, and artificial respiration by Sylvester's method or Richardson's double-acting bel- lows may be instituted. Laborde's method of reviving has, how- ever, appeared to me more efficient than anything else. It consists in seizing the tip of the tongue with a cloth or a forceps and pulling it forward so as to raise its root rhythmically fifteen to twenty times a minute. In giving chloroform, special attention has to be directed to the pulse, for when breathing stops under the use of that drug there is great danger that the heart will be fatally affected. In case of col- lapse during chloroformization, the best treatment is the combina- nation of artificial respiration with Nelaton's method, which consists in suspending the patient by holding her knees over the shoulders of an assistant or the edge of the table and letting her head hang down. I have succeeded every time with this combination. Another method that may answer a good purpose, even at a later stage, is Koenig's rapid compression of the heart. The ball of the thumb is pressed against the wall of the chest between the apex of the heart and the left edge of the sternum 120 times or oftener in the minute. When the pupils contract and the patient breathes, a pause is made until the former dilate again and the respiration stops. The application of a towel dipped in hot water to the precordium is also very effective. If there has been considerable loss of blood and the heart threatens to become paralyzed, an intravenous injection of a 6-per-thousand solution of common salt (sodium chloride) mav vet save the patient's life. Ether may be given with Goldan^s inhaler'^ (^^ig- 190), which may be used as an open or closed inhaler — that is, without or with the bag. If used without the bag, it need not be removed during the administration. At first, only a few drops of ether should be sprinkled on the gauze in the cone. A few seconds later a few more drops are added, and within a minute it may be dro]iped more constantly, and soon a small stream is substituted, carefully avoiding irritation of the larynx. "In this way the patient is grad- ' J. B. Ogden (Journal of Boston Society Med. Sciences, No. 15, June, 1897, p. 22) found albumin, or an increased amount of albumin in nearly 70 per cent, of cases anesthetized witli ether, and nearly 62 per cent, showed casts, or an increased number of casts. Strangely enough, there were generally as many casts after asmall operation and wlien a small amount of ether was used as after a great operation and the use of a large amount of ether. I have, however, no doubt that this is one of the causes of the success in rapid operations, compared with tedious ones. '■' .S. Ordmond Goldan, " Practical Anesthesia," Medical News, July 16, 1898. TREATMENT IN GENERAL. 221 ually brought under the full influence of the anesthetic in from three to ten minutes, and a slight dripping will suffice to prolong the effect. If the instrument is used in connection with the bag, it must be removed to pour on ether. By using closed inhalers, we expose the patient simultaneously to the action of ether and carbonic acid found in the expired air, a combination which works Fig. 190. Goldan's inhaler. well and has the advantage of counteracting the great refrigeration of the lung caused by the evaporation of the ether. Often a substitute is improvised by folding a newspaper and a towel together, so as to form a kind of cap, into the bottom of which is put a little absorbent cotton. About a fluidounce of ether is poured on the cotton, and more added when it has evaporated. Of late a practical and cheap ether-cone made of felt has been brought on the market. It can be disinfected by boiling it in water, and takes very little room in a satchel. As often a considerable amount of ether is used, it is best to have a pound of it on hand, Init divided into cans holding 100 granmies each. Even in hospitals it is better to have these small cans, because etl»er undergoes some change as soon as the can has been opened, in consequence of which it lo.ses part of its anesthetic power, and a larger quantity is needed to produce the same effect. The use of a hypodermic injection of morphine before giving ether (p. 206) does not abridge the time required to induce anes- thesia, but offers the advantage that very little is needed to keep up the effect. The vapor of ether is inflaninial)le. Great care must, therefore, i)e tiiken not to bring the ctlicr-coue or bottle too near the flame or in- candescent body when a cautery is used, or when tlie operaticm is performed with artificial liglit, or in a room with an open fire. It is safe to have gas-lights a yard above the operating tabh\' My own ' J. R. f'onite, " Ether et Chlorofornie," /ierut' mcdkalc de In Sui.-'si' liomdiide, 20 F^vrier, 1800, p. ST. 222 DISEASES OF WOMEN. experiments have, iudeed, proved that a compress saturated with ether does not cjitch fire from a burning candle before the flame is approached to the distance of one inch from below or from the side, and even half an inch from above. Ether vapor contained in the breath is not inflammable. Of chloroform it is well to have four ounces. It is best adminis- tered on Esmarch's mask (Fig. 191), consisting of a wire frame cov- ered with Canton flannel. The mask lies over nose and mouth, and the chloroform is dropped on it without removing it. Instead of the mask a pocket-handkerchief may be used, but then the face should be smeared with vaseline in order to protect the skin from irritation. The above-mentioned inhaler of Goldan may also be used for chloroform by removing the bag from the short cylinder of the instrument and covering it with four layers of gauze. Chloroform should be given in the dose of 5 to 10 drops poured on the mask at intervals of half a minute, or continuously drop by drop. The inspired air should never contain more than 4 per cent, of chloro- form vapor. Death from chloroform appears in four modes : (a) By syncopal apnaea ; (6) by epileptiform syncope ; (c) by paralysis of the heart with paralysis of the muscular system generally ; (d) by a combination of the effect of the anesthetic with surgical shock.^ Fig. 191. Esmarch's Chloroform-Mask. Since in chloroformization there is so much danger of paralysis of the heart, it is well to add -V grain of sulphate of atropine to the preliminary hypodermic injection. The A. C. E. mixture is administered with Allis's inhaler, from 20 to 30 drops at a time, repeated every half minute. Whatever anesthetic is used, false teeth should be removed before beginning ; a gag to separate the jaws, a long dressing forceps, and some gauze or lint should be within reach for the removal of froth, which sometimes accumulates in the throat. The tongue should always be kept forward, which can be done by pressing both rami of the lower jaw forward. Special tongue-forceps are found in the 'Benjamin Ward Kichardson, "On Death by Chloroform," The Asclepiad. 1st quarter," 1890. TREATMENT IN GENERAL. 223 instrument-stores. The tongue should not be pinched -vvitli artery- forceps, which causes bad-looking and painful ulcerations. Particular care should be taken when the elevated-pelvis position is used, as it tends to produce congestion of the brain. At all events, the patient should be anesthetized in the horizontal position, not kept inclined longer than necessary, and brought back to the hori- zontal position, at least temporarily, if she becomes cyanosed. Cocaine. — Although great operations, such as ovariotomy and am- putation of the breast, have been successfully performed under the anesthesia brought on by hypodermic injection of hydrochlorate of cocaine, so many cases of alarming depression following the use of even very small doses are on record that I think the use of this drug should be very limited in gynecological practice. Mere fright caused by seeing or hearing the surgeons at work may be fatal. It is, however, in many cases, a great advantage to dispense with general anesthesia, and it has been noticed that the dangerous collapse is less likely to occur the farther away from the liead cocaine is used. I have been well satisfied with the application of a 10 per cent, solu- tion before cauterization with chloride of zinc in diphtheritic inflam- mation of the genitals. The cervix may be dilated without pain after pledgets soaked in a 5 to 20 per cent, solution have been placed for five minutes around it, and in its cavity, if it is sufticiently wide to allow it. Beta-eucaine may also be used. In cases in which general anesthesia was deemed to be too danger- ous on account of heart disease, even the largest oj)erations, such as ovariotomy and abdominal hysterectomy, have been performed with local anesthesia produced with a spray of chloric ether, or ethyl chlo- ride. This substance is, at a temperature below 50° Fahr., a fluid. It is stored in tubes and a stream of the rapidly volatilizing fluid be- comes a spray. It should be held 10 inches away from the part treated in order to avoid excessive and useless cold. The gas is very inflammable, and in operations the neighborhood of a flame must be avoided. Whatever agent be used to produce anesthesia, the most powerful sfimnlants should be kept ready. A few drops of nitrite of amyl are good where there are signs ot" anemia of the brain (chloroform, cocaine). Hypodermic injections of 10 miuitns of tincture of digitalis often in- crease the volume of a sinking j)ulse or bring it back when it is in- discernil)le.' .Sj)iritus glonoini (/. e. nitroglycerin), Til i to iv, is also a reliable heart tonic : I^. Spts. glonoini, Vt\y ; A(juie (lest. HJ. M. S. — One or two hy[)(>(l('rmi(' syriugefids 0> twenty minims. ' The injection of camphor dissolved in acetic ether, used in several hosj)itals of this city !is well as clscwiiere, ought to he discarded, as it in sevi-ral cases lias pro- duced paralysis. 224 DISEASES OF WOMEN. Strychnine has a powerful effect on respiration.^ Injection of TTL xxx of a solution of 1 part of camphor in 4 parts of sterilized olive oil into the deltoid or vastus externus muscle is efficacious and harmless.^ Faradization of the diaphragm may occasionally prove useful. Against the collapse caused by cocaine, inhalation of nitrite of amyl, subcutaneous injections of ether or caffeine, or a warm or cold infusion of coffee by the mouth have been recommended. Both ether and chloroform are very apt to cause vomiting. The patient should, therefore, not have any solid fo(xl the day of the opera- tion. When she vomits, she should be turned on her side, so as to give the ejected masses a free outlet and prevent their entrance into the larynx. After the operation she should only have hot water or ice-water in teaspoonful doses to relieve her thirst until all nausea has stopped. A little black coffee is grateful, and seems to have a good effect on the stomach. If vomiting continues, I give, with ex- cellent effect, the following mixture : I^i. Acidi hydrocyanici dil., .5ss ; Acidi citrici, Sodii bicarbon, da. 5ij ; Syr. rubi Idsei, sss; Aquae, ad 3vj. — M. Sig. A tablespoouful every one, two, or three hours. Shock. — A common and exceedingly dangerous occurrence during or after operations is shock, or collapse, the sudden giving out of vital force. This condition may appear with two different types, the erethistic, in which the functions of the sympathetic nervous centers are partially abrogated, and the torpid, or apathetic, in which the cerebrospinal nervous centers are affected as well as the sympathetic. In the first the cardiac ganglia become weak, and the blood-vessels lose their tone, the effect of which is that the blood accumulates in the veins, and virtually an internal bleeding takes place. The patient retains consciousness, but is restless, thirsty, and often nau- seated. She sighs for more air, the skin is cold and clammy, her pulse rapid and feeble. In torpid shock we have a similar condition of the skin and pulse, but no dyspnea, thirst or nausea, symptoms which demand an active brain. Often the patient loses control of her sphincters. Sometimes she is a little delirious or has convulsions, ^ Horatio C. Wood of Philadelphia has made special experiments in regard to the effect of drugs during anesthesia, and laid the results before the International Medi- cal Congress in 1S9U [Abstract in Practice, Feb., 1891, p. 58-59). According to him, alcohol is inetrective in small doses and dangerous in large. Nitrite of amyl, caffeine, and atropine are of little or no use. Ammonia has some little influ- ence on the heart. He recommends digitalis for the heart and strychnine for the respiration. ^ H: C. Coe, The Sew York Polyclinic, vol. i. No. 1, p. 20. TREATMENT IN GENERAL. 225 more commonly she is in stupor. As a predisposing cause of shock must first of all be mentioned fear, which sometimes has proved fatal before an operation or anesthesia was begun. In this respect we cannot impress too strongly upon the mind of operators and anes- thetists the importance of cheering the patient up and of inspiring her with confidence. AViieuever possible the patient should be anesthetized in another room than the one in which the operation is performed, so as to spare her the view of instruments and of appa- ratus needed during the same, which especially since the introduc- tion of antisepsis and asepsis often have an appearance out of all proportion to the magnitude of the operation itself. Any other thing that weakens the constitution or the momentary condition of the patient, likewise predisposes to shock. The exciting causes are loss of blood, too deep anesthesia, length of operation, refrigeration, ner- vous reflex, and idiosyncrasy. By means of pressure-forceps, the preventive elastic ligature or digital pressure, ligation of vessels, either speedily after their severance or before cutting them, hemo- static suture, tamponing, hot water, cauterization and styptics, loss of blood is prevented or checked. The best man available should be chosen to administer the anesthetic, and he should be thoroughly conversant with the dangers attending anesthesia, a condition verg- ing on death. Many more deaths are due to anesthesia than to tlie work of the operator. A loss of animal heat is exceedingly dan- gerous, the room in which an operation, especially one in which the large abdominal cavity is exposed, should be at a temperature be- tween 70° and 80° F. The above-mentioned leggings (p. 207) may be of use. The operation should be simplified and abbreviated as much as other considerations allow us to do. Handling of the in- testine siiould l)e avoided as much as possible, which is much facili- tated by the elevated-pelvis position.' The removal of the uterus seems to expose much more to shock than that of the appendages. Some individuals cannot take any kind of anesthetic, since they stoj) breathing as soon as consciousness becomes slightly dimmed. If a j>r()tracted and bloody operation may be auticij>ated, it is well to (•()mpress all four ('xtremiti(?s at their base with i)ieces of a roller-bandage, so as to Ibrm reservoirs of blood which may grad- ually be opened when the pulse weakens. Strychnine (gr. -r^^J uj) to j',j), tincture of digitalis (ITI x u]> to 3 ss), and nitroglycerin (gr. y/j,, up to Jjj- ) should be injected under the skin, the above-mentioned camjihor solution into a muscle. Hot saline solution ((] parts ol' chloride of sodium to 1000 parts of water, or a flat teas])oonfiil dis- solved in a (juart of water) at a temperature of 120° V.. ouo to two f[narts are, during tho operation, and while the patient is anesthetized, ' (loltz ha.s shown that a contimiatinn of small, ii).sigiii(ic'aiit raps on tlif Ijoliy of .1 frog kills it. 15 226 DISEASES ^F WOMEN. Fig. 192. injected slowly, not faster than a quart in ten minutes, into the basilic vein. If a juore prompt effect is not needed, the same fluid may be injected into the rectum, and this way is used for the repetition of the injection, whicli is adnn'nistered for an hour at the time, with an hour's interval until the pulse at least has come down to 120 per minute.^ The operation should be finished in the shortest possible time, leaving out measures which are not absolutely necessary. If the abdominal cavity is open, the saline solution may be poured from the pitcher into it. After the operation the patient should be handled very carefully, and the head should never be raised above the trunk in removing her from the operating table. She should be placed in a warm bed, and surrounded by half a dozen bottles or bags filled with hot water. Great care should, however, be taken not to have the water so hot that it burns. The nurse, must try the temperature by holding the vessel in contact with the back of her hand. If the water is too hot, the bottle may be wrapped in a towel or placed outside of the blanket. The foot of the bed should be raised on a chair, so as to keep the blood gravitating toward the brain. No pillows are to be placed under the head. The hypodermic injection of the above-mentioned stimulating drugs is repeated according to circumstances and within the limits indicated. Kub- bino' of the skin and kneading of the muscles of the extremities are useful measures in bettering the peripheral circulation. Strong spirits of ammonia held under the nose stimulates the nervous system. The saline solution may also be injected under the skin (hypodermoclysis). The best place for this subcutaneous injection is between the clavicle and the breasts. A pint of fluid is injected, and the injection repeated when needed. To further absorption, the region sh(nild be mas- saged during injection ; still, it is a rather slow process. Common Instruments and Their Use. — Some instruments are so generallv Garriimes' Weight Speculum, i^ i ^.i j. xi i i /> ^' r, r useiul tliat they are needed lor nearly all gynecological operations, and should always be on hand. Such are a uterine sound (p. 154), bivalve and univalve specula (pp. 146 ' Robert H. M. Dawbarn of New York, Med. News, Feb. 25, 1899. TREATMENT IN GENERAL. 227 and 147, a vaginal depressor (p. 149), tenacula, volsellse) sponge- holders, knives, scissors, several pairs of artery-forceps (pp. 190, 191) needles, a needle-holder. With some of these we are already- acquainted from the chapter on Examination. In regard to the others I shall make a few remarks. Fig. 193. Schrocdcr's Vaginal Retractor. Weight Speculum. — For certain operations which are best per- formed with the patient in the dorsal posture, such as traclielor- rhaphy and vaginal hysterectomy, it is a great advantage to have a speculum that is held in place by its own weight, and at the same time can be easily removed and replaced (Fig. 192). Fig. 194. Eugelmanii's vaginal retractor. Vnf/inal Retractors. — Besides the specula and depressors described in speaking of how to make an examination, Idteral retractori<, sucli as Schroeder's (Fig. 193) or Eiigelmann's (Fig. 194) are often needed in operations in the dorsal position. Fig. 195. L 3 Emmet's Tenaculum. Tenacula. — A tenaculum is a sharjvpointed steel hook with handle, which should be made of one piece of metal. Two sliajM'S of iiooks are most convenient : oiu; is simply bent .so as to lorm a little less than a right angle ; in the other the j)oint has a second flexure in the direction of the handle (Fig. 19o). 228 DISEASES OF WOMEN. Tenacula are used to put tissue on the stretch, to lift up tissue to be cut, to manipulate silver sutures, etc. Volsella. A volsella (Fig. 196) is a pair of forceps, each blade of which ends in a double hook. It is used for seizing and pulling tissue. For Fig. 197 plan's Traction-forceps. vaginal hysterectomy Pean's traction-forceps (Fig. 197) is excellent and almost indispensable. A tenaculum-forceps is a modified volsella with single or double hooks, and, as a rule, of more slender build. A tissue-forceps (Fig. 198) is a pair of forceps with side teeth, con- venient for holding a strip of tissue while cutting it off. Fig. 198. Tissue-forceps. Another tissue-forceps which I have found superior to any other instrument for holding flaps of peritoneum and similar delicate tis- sues is that of Kocher (Fig. 199), which ends in two teeth on each branch, with comparatively large seizing-surfaces, by which arrange- ment they are much less apt to tear the tissue grasped than other instruments are. A sponge-holder (Fig. 200) is an instrument formed like a for- ceps, with ring-shaped ends between which the sponge or pad is held. It may be replaced by any other forceps of suitable length and grip. TREATMENT IN GENERAL. 229 Knives are used much less than in general surgery. A medium- sized scalpel is about all that is needed. Fig. 199. Kocher's tissue-forceps. Scissors are in- most cases used to great advantage as cutting instru- ments. They cause less hemorrhage than knives, are more expedi- FiG. 200. Hunter's sponge-holder. tious, and can do more delicate work. Often they are used closed as a blunt instrument. The chief shapes needed are straight, curved on the flat, and knee-bent on the edge. They must for most purposes have long shanks. When a surface is to be ])arod a tenaculum is passed into the mucous membrane at the end nearest to the operator and at the lowest part of the field to l>e denuded, so as to avoid having l)lood running over the upper part that is to be denuded later. The mucous mem- brane is lifted a little, and the scissors arc made to cut off a thin strip of tissue under the teuacuhim in such a Avay tiiat the tenaculum stays in the loo.sened strip. When once tlie strip is cut loo.se, it is often more convenient to exchange the tenaculum for a tia'^ue-forceps. The strip shoidd be cut of as uniform breadth and thickne.'NS as possible, and from one end of the surface to be denuded to the otiier. If this is wider than the strij), one or more similar strips are cut off ])arallel t^) the first, taking great care not to leave any j)art inideinided. While this is in process, tiic denuded surface is kept free from blood by irri- 230 DISEASES OF WOMEN. gation or sponging. Especial care is also taken to get a regular line of incision all around the pared surface without any projecting tongues or receding bays. Pressure-forceps, of lighter or heavier construction, are put on bleeding vessels. If it is a large vessel that spurts, the pressure- forceps takes simply the place of the old artery-forceps before the vessel is secured by means of a ligature, but on small vessels the pressure exercised by the pressure-forceps suffices within a few min- FiG. 201. Needles : a, short straight round ; 6, long straight round ; c, trocar-pointed straight; d, semi- curved, crescent-ground (Sims's fistula-needle) ; e, semi-curved, trocar-pointed (Emmet's cervix-needle) ; /, curved, crescent-ground; g, curved, trocar-pointed ; h, i, old-fashioned strongly curved surgical needles with three edges ; j, semicircular Hagedorn needle; k, half-curved Hagedorn needle ; I, fishhook-shaped needle. utes to arrest the hemorrhage permanently, so that no ligature is needed. Needles. — A variety of needles (Figs. 201 and 202) are used, and special kinds made for gynecological work have in certain operations been found preferable to the old-fashioned needles used in general surgery. We use straight, more or less curved, round, trocar- pointed, crescent-ground, Hagedorn, and handled (sharp-pointed or dull) needles. In soft tissue, such as the intestine, straight or curved English sewing needles are used. But where the tissues offer much resistance it is necessary to make the round needle cutting near the point by grinding it so as to form a crescent-shaped surface with two cutting edges, or three sharp edges like the point of a trocar or a spear. Hagedorn's needles are flat from side to side, with a straight cutting edge near the point. They have a very large eye, which makes them particularly useful when catgut is used. When the suture inserted with Hagedorn's needles is tightened, the TREATMENT IN GENERAL. 231 edges of the wound made by the needle are drawn together from side to side, instead of being pulled apart, as is the case when a needle is used that cuts at right angles to the direction of the suture. Fig. 202. Needles with Handles : a, slightly curved, sharp-pointed or dull : b and c, strongly curved, dull ; d, Marey's needle, sharp-pointed, with eye from side to side. In order to avoid turning or breaking of the curved needles when grasped by the needle-holder, the part nearest the eye should be Fia. 203. Uagedorn'B Needle-holder. straight and fiat. For operations on the intestines long Englisii <'anii)ric needles, about No. 7, or tine curved ones are used. 232 DISEASES OF WOMEN. Needle-holder. — For all these needles a needle-holder is needed. Hagedorn's (Fig. 203) is adapted to his needles, and Crosby's can be used for any needle, opens by mere pressure, and is easy to disinfect (Fig. 204). As a rule, the needle-holder should be applied to the needle just in front of the eye, for if the latter is comprised in the grasp of the forceps, the needle is very liable to break. Mucli time is saved and a good adaptation more easily obtained by using handled needles (Fig. 202), but in order to be strong enough to pass through resistant tissues they must be made so thick that they make a large hole, Avhich, however, immediately contracts, and, there- FiG. 204. Crosby's Needle-holder. fore, is without importance if the patient is anesthetized. When only slightly curved and ending in a sharp point, these needles are partic- ularly useful for closing wounds in the perineum or the abdominal wall, and are often called perineum-needles (Fig. 202, a). They have the eye near the point, and are threaded after having been pushed through the tissue. A blunt needle of this kind is used in ovariotomy and similar operations, and will be described later. Instead of a needle and needle-holder a ligature-carrier (Fig. 205) may sometimes be used with advantage. It is a half sharp-pointed Fig. 205. Cleveland's Ligature-carrier. curved forceps, between the jaws of which the ligature is seized and carried around the tissue to be ligated. It makes large holes, and I TREATMENT IN GENERAL. 233 prefer therefore, Schroeder's needle. Mallett's ligature-carrier (Fig. 206) has the advantage of being automatic. Fig. 206. MaUett's ligature-carrier. Ligatures. — For ligatures silk or catgut is used (pp. 212—216). They should be tied in the so-called square knot, and, as we have seen above, catgut requires sometimes an additional knot. In most opera- tions the ends are cut short and the ligature left in the body. Under particular circumstances (sec Lupus Vulvte, Fecal Fistulae, Fibroids of the Uterus, etc.) the elastic ligature of rubber is used. It consists in solid round strings varying in diameter from less than jlg- up to ^ inch, or in rubber tubing twice as thick. Rubber soon loses its elasticity, and in order to be reliable a ligature of this sub- stance must be rather new. It is, however, said to preserve its elas- ticity for a whole year or more by being kej)t in a 4-per-thousand solution of bichloride of mercury in alcohol.' l^utaroi. — The chief materials used for sutures are silk, catgut, silver wire, silkworm gut, and kangaroo tendon (pp. 212-216). Silk is generally tied in a surgical knot, for which catgut and silkworm gut are not pliable enough. Where the surgical knot cannot be used, an assistant may by pressure prevent the suture from opening while the second knot is Ixiing tied. Silk sutures may be left in the abdominal wall for a week. Silk sutures placed near a drainage-tube or a tampon, from Mhich septic material may come, are apt to become secondarily infected. In order to avoid this, they should not be used in such places, but pref<!ren(H' given to silver wire or silkworm gut, wliicli do not al)s()rb fluids. In tlu; vagina I have often left silk sutures for a month without causing suppuration or cutting through. ' Fiisola and Martinetty, Cnilmlblalt /. (iyndk., ISUl, Nov. 24, p. 50t;. 234 DISEASES OF WOMEN. When silk or silkworm gut is to be removed, the ends are seized with a pair of pressure-forceps and slightly lifted ; the end of one blade of a pair of sharp-pointed scissors is inserted under the suture, and the latter is cut close up to the skin or mucous membrane on one side, in order to prevent that part of the suture that has been exposed, and often is dirty, from being drawn through the stitch- canal. Silver wire may be fastened directly in the eye of a needle — e. g. in stitching a torn perineum — but for most plastic operations it is necessary to use a thread of silk, linen, or hemp as a ivire-carrier. Both ends of a linen thread (No. 70) two feet long are passed from the same side, one after the other, through the eye of the needle, and then the two ends together are tied with the loop on the other side of the needle, so as to form a half knot just behind it. If the free ends are made about 4 inches long, we get a loop about 8 inches long. A piece of silver wire 10 or 12 inches long is bent at a distance of f of an inch from one end under a sharp angle, which is done by seizing it in a needle-holder and bending it close up to the edge of the instrument. At the same time we straighten the wire and ascer- FiG. 207. Two Denuded Surfaces, showing where the sutures lie. tain that there are no kinks in it by sliding the nails of the thumb and middle finger down its full length. The hook thus formed at one end of the silver wire is passed through the loop of the thread and given a little twist, so as to prevent it from coming oif. When one pared surface is to be applied against the other, the needle is, as a rule, inserted from a quarter to half an inch from the outer edge of one of the denuded surfaces, carried deep in under the same, and pushed out ju.st on the inner line between pared and unpared tissue, reinserted at the corresponding point on the other side, and pushed out from a quarter to half an inch beyond the pared surface (Fig. 207). When the point of the needle emerges from the tissue, a dull hook^ TREATMENT IN GENERAL. 235 much like a button-hook and called a counter-pressure hook (Fig. 208), is inserted under the point and pressed against the tissue, while Fig. 208. fV. Emmet's Counter-pressure Hook. the operator pushes the needle farther in. Next he takes the needle- holder off from the posterior part of the needle aud seizes the point above the counter-pressure hook, and pulls the needle through. When the thread has been drawn through under both surfaces, it is suddenly pulled on, so as to jerk the silver wire through the tissue. When the wire is pulled halfway through, the hook is detached from the loop, and one end of the wire is made to form a slip-knot round the other, and this suture is temporarily put aside until all have been inserted. Only if there is much hemorrhage, it may exceptionally be neces- sary to close a suture immediately after paasing it. When all the sutures are in place we proceed to close them, begin- ning with the uppermost. The slip-knot is pushed down and the free end pulled farther out, taking care not to cut the tissue with the wire, until the loop is reduced to a little over an inch in length. The two ends are now seized below the slip-knot with tlie wire-twister (Fig. 209), the long free end cut off, the suture drawn taught and shouldered — /. e. belit with a tenaculum at the point that will come to lie just Fig. 209. Emmet's Wire-twister. at the line of union when the edges are brought together (Fig. 210). Next, the suture-Hhield (Fig. 211) is placed around both wires and pushed gently down to the tissue. Tiie wires are now bent against the siiarp inner edge of the shield, and turned round until the twist(<l part thus formed just reaches the shield. This is the nicest point in the whole procedure. If you do not 236 DISEASES OF WOMEN. Fig. 210. twist enough, the suture will be loose and not bring the denuded edges in contact ; and if you twist too much, you will strangle the tissue included in the loop, and the suture will cut through. While the end is still held with the twister the shield is withdrawn, a tenaculum pressed against the wire just where the twisted part ends, and the latter bent to a side at right angles to the line of union. At a distance of half an inch the tenaculum is pressed against the twisted wire, another right angle formed, and the end cut off at this point. The wire should lie quite flat against the skin or mucous membrane. When there are many sutures, it is sometimes an advantage to turn them alter- nately to either side. The number of sutures should always be counted at the end of the operation and marked in the history of the case, as they sometimes become so imbedded that they are hard to find. I have seen a forgotten silver suture work its way into the bladder and form the nucleus of a stone, and have heard of over- looked silk sutures causing septicemia and death. Shouldering Wire Suture: a, twisted suture bent to a side and cut short; b, shouldered suture. Fig. 211. Sims's Suture-shield. In most operations silver sutures are left in for nine days, but on the cervix some leave them for a month, in order to ensure reliable union or to save a perineum operated on at the same time. When the time comes for removing them, the end is seized with the twister ; the suture is pulled gently up until a minute triangular space appears between the wires and the tissue; one point of the wire-scissors, a strong pair of curved scissors with rather sharp points, is inserted under one of the wires, which should be cut close up to the point where it enters the tissue ; and finally the twisted end is pulled in the direction of this same point, by which we press the newly-united edges against each other, instead of pulling them apart. Slight irregularities caused by the imbedding of the wires disappear soon after their removal. The kind of suture most used in gynecological work is the inter- rupted. Rarely the quilled suture is required. The continuous, or running, suture is often used in laparotomy, in bringing together the TREATMENT IN GENERAL. 237 edges of the peritoneum, aponeuroses, or fasciae. Some use it also much in plastic operations for lacerated cervix, cystocele, or pro- lapse of the uterus. A particular modification of this suture is the so-called continuous tier-suture (Fig. 212). Fi«. 212. Beginning of a Catgut Tier-suture (A. Martin). Suppose an oval denudation has been made on the anterior vaginal wall. The needle, armed with a catgut tliread a yard long, is carried through both edges and under the whole pared surface from the operator's right side to the left, near the upper end of the wound. The catgut is pulled through until within about three inches from the end, and tied in a knot as for an interrupted suture. The free end is seized and drawn uj) witli a i)ressure-forceps. Then several turns are made in the same way below the first, but with a continuous suture, always drawing the thread taut. Wiien the tension becomes too great, the needle is not carried under the whole wound-surface, but only under the part of it lying nearest the median line, thus placing a deep tier at the l)ott<)m of the wound. Wiien the operator reaches the lower narrow part of the oval, he comprises again the edges in the suture, l^ necessary, a second tier ol" buried sutures may l)e placed over the first (Fig. 213), avoiding interference with it, and finally the superficial tier is inserted. The best way of knot- 238 DISEASES OF WOMEN. tiug the suture is by pulling the free end so far out that it can be tied together with the loop carrying the needle. This method of suturing is expeditious, and has the advantage of bringing broad surfaces in contact witli each other. Interrupted sutures may also be placed in tiers above one another — e. g. in closing the abdomen after laparotomy. Fig. 213. Second Deep Row of Tier-Sutures (A. Martin). The looped, or glover's, suture is a continuous suture in which each loop is closed bv passing the needle through it. This suture is valuable for arresting hemorrhage and diminishing the length of the line of suturing. Chain-suture is used to secure thick pedicles, and will be described under Ovariotomy. Sponging and Irrigation. — During most plastic operations veiy small sponges or pads on sponge-holders are needed, and the assistant should press the sponge very gently against the bleeding place, with- out rubbing it, and he should always keep those points clean where the needle is to be inserted or pushed out. In operations performed in the dorsal decubitus irrigation with some hot antiseptic fluid or hot sterilized water rnay advantageously be substituted for sponging (pp. TREATMENT IN GENERAL. 239 186 and 209) ; and under all circumstances it is advisable to irrigate the wound before closing the sutures and to remove all clots. The smoother and cleaner the cut surfaces are, the sooner they will grow together by first intention. Haw to Clean and Disinfect Instruments. — Instruments should be boiled in a solution of soda before every operation (p. 209). After an operation they should be scrubbed with soap, lukewarm water, and nail-brush, rinsed with clear water, and wiped perfectly dry M'ith at least two towels. During the operation they should be innnersed in sterilized water or a 2| per cent, solution of carbolic acid. Selection of Instruments. — In preparing for an operation, the ope- rator or his assistant should carefully go through the different steps of the operation in his mind, and take out all instruments that are sure to be used ; but, besides, he ought, within reasonable limits to prepare himself for the unexpected by having such instruments in readiness as may be required under certain eventualities, and by having more than one of the most indispensable instruments, such as knives, scissors, needles, pressnre-forcejis, etc. After-treatment. — If there is no danger of shock, the best way is to let the patient sleep after the operation until she wakes of- her own account ; but if there is shock, it is better to rouse her by aspersion of cold water, shaking, talking, etc. If she vomits, the measures recommended in treating of anesthesia (p. 220) should be taken. For the thirst, frequently repeated teaspoonful doses of hot water are often good, but in other cases nothing is like small quantities of ice-water. Ice itself docs not quench thirst. An injection of tepid water into the rectum has sometimes proved useful (p. 174). No food is given as long as nausea continues. As a rule, a fluid diet of peptonized milk, buttermilk, kumyss, matzoon, l)eef-tea, and oatmeal gruel may be begun the day after the operation. Nothing solid should be taken until the bowels have been moved, which in perineal operations is done on the fourth day, and in laparotomies and vaginal hysterectomies on the third, by giving castor oil, laxol, com- pound licorice powder or sodium sulphate. (See Ovariotomy.) Pulse, temperature, and respiration should be marked grapliically on charts, so that the surgeon may judge of the condition at the first glance. The nurse should also keep a record of food taken, urine excreted, and movements of the bowels. 240 DISEASES OF WOMEN. CHAPTER HI. Internal Treatment. Few gynecological diseases can be cured by internal treatment alone, but, combined with external treatment, the internal is a valu- able and often indispensable adjuvant. The reader is, of course, supposed to be conversant with general therapeutics. He will ever bear in mind that the body from the ver- tex to the sole forms one system, all parts of which are most inti- mately connected ; he Avill watch for symptoms pointing to disorders in any division of the body ; and in his treatment of gynecological cases he will make such modifications as are called for by the condi- tions of other organs or the constitution in general. Food and Drink. — Most gynecological patients are suffering from anemia, and often from anorexia at the same time. Attention must therefore, first of all, be paid to their diet. They should be encour- aged to eat as much albuminoid food as possible, and, by taking six small meals a day instead of the usual three more copious ones, much can be done to increase the amount of food taken every day. The physician should give as precise orders as possible in regard to time, quality, and quantity of meals, and look to a proper variety in order to avoid disgust. jVIild alcoholic drinks, such as beer, Johann Hoff' s malt extract, Liebmann's Teutonic, Anheuser-Busch's nutrine, Pabst's Best tonic, Rhine wine. Moselle wine, French or Hungarian claret, Burgundy, vin Mariani, port, or tokay,^ should be taken with meals unless especially contraindicated. Beef-tea may be made of extracts or of fresh meat. A pint of cold water acidulated with a tcaspoonful of dilute hydrochloric acid is poured on a pound of minced lean beef. The mixture is stirred once every quarter of an hour for an hour and a half. Then it is put over a fire until it reaches the boiling point. Strain, and add salt to taste. A still more nourishing preparation of beef may be obtained by mincing a pound of lean meat, mixing it with a pint of cold water and two teaspoonfuls of dilute hydrochloric acid. The mixture is put on ice for an hour and during that time off and on pressed with a wooden spoon. It is then strained and replaced on ice. About two ounces should be taken every two hours. ' Where economy is an object, the strong California wines, such as port, sherry, angelica, and tokay, are to be recommended. Good wines such as the '' Sunset " tokay can be obtained for 50 cents a bottle. These wines are certainly much to be pre- ferred to the cheap mixtures often sold as imported wines. TREATMENT IN GENERAL. 241 If the patient is unable to dispose of so large a bulk, the beef may be boiled without water in a bottle immersed in water. A few teaspoonfuls of the strong juice obtained in this way is given at a time. Strong bef^f-juice is also secured by broiling slices of beef and pressing them in a little machine made for the purpose. Weir MitcheWs rest cure, in which the patient is removed from her friends, put to bed, fed by a nui-se to the limit of her digestive powers, and treated w^th massage and electricity,^ may be indicated in exceptional cases, but, as a rule, gynecological patients should be encouraged to take as nuich exercise in the open air as they can with- out increasing their sufferings. If the patient cannot digest her food, slie should take pepsin and hydrochloric acid after each meal : I^. Pepsins, Sij ; Acid, hydrochlor. dilut., ^ij ; Syr. aurant., Sss ; Aquae, q. s. ad oviij. — M. Sig. Shake well. A tablespoonful after meals. I have also found Parke, Davis & Co.'s pepsin cordial, a tea- spoonful three times a day, very beneficial. In severe cases of indigestion even redal alimentation may become necessary.^ Xutrient enemas ought not to exceed six ounces in bulk, as otherwise they are apt to be ejected. The bowel ought first to i)e emptied by a [)laiu salt-water injection, and the nutrient enema ought to be injected very slowly, so as to avoid irritating the bowel. Appropriate mixtures for rectal feeding are an egg beaten up with four ounces of milk, with or without addition of an ounce of whisky ; l^eef-tea, witli addition of one of the extracts found in the stores, such as Licbig's, Armour's, etc. ; or four ounces of lean beef finely chopped togetiier, witli one ounce of "white liver" — /. c. pancreas — adding water enough that the mixture can be injected with a Davidson's syringe. Very commonly gynecological patients suffer from constipation and need some (ipericnt. A heaping teaspoonful of Carlsbad salts' or sulphate of sodium, dissolved in a tumblerful of hot water and taken on an em|)ty stomach in the morning, often effects a cure in the course of six we«'ks. A heai)ing teasj)oonf'ul of conij)ound licorice powder, tiiken in the evening, gives a passjige the next morning, and ' S. Weir Mitdiell, /•'(/ mid lilood, and how to M<tl;e tlinn, 2d vd., I'liiladelplii.-i 1K78. '•' An important paper on this snhjecf, \>y TIcnry F. ('aniplR'll of Aiit^iista, (ia., is found in 7Va7M. Aim-r. Gyn. Soc, 187H, vol. iii. p. 'JtiS, <•! sn/. * Tlie artificial salt seems to be jimt as ^"'"1, 'IikI t-osts only one-foiirtli of tlie im- ported. 1« 242 DISEASES OF WOMEN. many like that powder. As a rule, I combine the aperient with a tonic by giving Bland's pills with aloes : Iji. Ferri sulph., Potass, carb., aa 3ij ; Aloes Socotrinse, gr. v to xv ; Extr. gentianse co.. q. s. Ft. pil., No. Ix. Sig. Three pills three times a day, after meals. Sometimes nausea or vomiting call for symptomatic treatment. They should be treated with bismuth, for instance : ^i. Bismuthi subnitr., sij ; Magnesias carb., Sacchari albi, da. §ss. — M. Sig. A heaping teaspoonful three times a day, between meals ; or Liq. iodi co. (Ttlj every two hours) ; creasote (TUj every three hours) ; ac. hydrocyan. dilut. (Tlliij every one to three hours) ; tinct. nuc. vom. (TTLiij every three hours), each diluted with a tablespoon - ful of water ; cocaine hydrochlorate (gr. ^ every two or three hours) ; cerium oxalate, oroxine hydrochlorate (gr. iij to v, t. i. d., in pills or capsules). Tonics are nearly always needed, especially iron, quinine, strych- nine, arsenic, and phosphorus. Clinical experience shows that the solution of ferrous malate (American Pharmaceutical Manufacturing Company) and the compound tincture of cinchona, equal parts, in spite of the chemist's protest, is an excellent tonic. — M. Sig. A teaspoonful three times a day. Another valuable combination is the following : I^. Strychninae sulph., gr. j ; Ferri et quininae citrat., sij ; Syr. aurant., 5ss ; Aquae, q. s. ad siij. — M. Sig. A teaspoonful in a wine-glass full of water, three times a day, after meals. Plain Blaud's pills are also good. If a malarial element is pres- ent, full doses of quinine and other antipcriodics are required. In carnogen, the extract of red bone-marrow, given in teaspoonful to tablespoonful doses, either alone or in combination with other tonics, we have a new and powerful remedy against anemia : I^'. Liq. Fowleri, 3J ; xVc. phosphor, dilut., .^ss ; Carnogen, q. s. ad 5iv. — M. Sig. A desserts])oonful three times a day after meals. TREATMENT IN GENERAL. 243 In tympanites, so often accompanying gynecological diseases, strychnine answers an excellent purpose. Anodynes are sometimes indispensable, but they should only be used for a short time and in as small doses as will suffice. Magen- die's solution of morphine, 4 to 8 drops three times a day ; tincture of opium, 15 drops; or suppositories with 1 grain of pulvis opii every three hours, are the most common anodynes. Hydrobromate of hyoscine, gr. j^-^, has been much praised of late. I find phenac- etine, in doses of 7^ grains, repeated after one hour, and if needed a second time after three hours, has an excellent effect in relieving pelvic pain. Extract of conium in the dose of 1 or 2 grains, t. i. d., is also good. Iodoform or aristol, 5 grains, in suppositories, t. i. d., often dulls pain. Headache is often banished with almost magic promptness by the following powder : I^. Phenacetini, 3j ; Caffeinae, gr. xxiv ; Sodii bromidi, .^ij. — M. Div. in chart, cerat.. No. xii. Sig. One powder, repeated, if needed, after one and three hours. Among sedatives, the bromides of ])otassium, sodium, and ammo- nium, single or combined, are often required. An embrocation with chloroform (1 ])art) and olive oil (3 parts) gives at least temporary relief in the troublesome backache so generally complained of. If the patient is troubled with insomnia, it has to be met with one of the many hypnotics chemistry has offered us in late years. I iiave been ])articularly pleased with sulphonal (gr. x), chloralamid (gr. xlv), or trional (gr. xv). Resolvents are often called for in chronic inflannnations. The most important are iodine, gold, and mercury. We have spoken in another place (pp. 174 and 106) of tiie application of tincture of iodine to the vaginal roof and the abdominal wall. Internally, iodine is best given as iodide of ])otassium, gr. viij-x, t. i. d. The chloride of sodium and gold has seemed to me to have a decided effect, espe- cially in chronic oophoi-itis. It is given in the dose of gr. I to ^, t. i. d., after meals. Tiic bichloride of mercury (gr. ^,j, f. i. d.) has been recommended in chronic metritis. HaiwxUdicH. — In acute hemorrhages from the womb, menstrual or intermenstrual, ergot is the best drug (Extr. ergotse fl. .^j, i. i. d., or so-called ergotin, gr. ij, /. /. '/.). It works by causing contraction of the unstrip(Ml mnscU^-fibcrs c()mj)osing the l)ulk of the W(tmb and those found in the walls of the arteries. It is also useful in subin- volution, chronic metritis, active or j)a.ssive hyj)eremia, in intranuiral 244 DISEASES OF WOMEN. and submucous fibroids, but not in polypi, in which it is apt to increase the hemorrhage. In chronic cjises cotton-root is in my experience superior to all other remedies, whatever the cause of the hemorrhage may be/ The fluid extract is not so efficacious as a decoction prepared fresh every morning by boiling three heaping teaspoonfuls of rasped cotton-root bark with one pint of water for a quarter of an hour, during which one-half of the fluid evaporates. It is then strained, and one-third taken cold three times a day (I^. Gossypii radicis corticis raspati, 5iv). This decoction not only checks hemorrhage when present, but seems to have a tonic influence on tlie uterus and the general health. The patients may take it for months, only interrupting its use from two to four days in the beginning of menstruation. I have found that in fibroids it even takes the concomitant pain away, besides checking the hemorrhage and arrestino; the growth of the tumor. It works, like ergot, by causing contraction of the muscular tissue of the uterus, and is often used in the South to produce abortion. Another uterine hemostatic that I sometimes have seen help when the two first named had failed is the mistletoe {^,. Extr. visci albi fl, oij- Sig. A teaspoouful three times a day). Bromides are good when the cause of the hemorrhage is nervous excitement. If malaria is at the bottom of it, quinine, followed by small doses of arsenio (Liq. potass, arsenitis, gtt. iij to v, t. i. d.), is indicated. Ar.-^enic is also recommended in the menorrhagia of grow- ing girls and young women, and that occurring at the climacteric. In syphilitic patients mercury is to be prescribed. Digitalis is recommended for the passive hyperemia consequent on weakness of the heart or mitral insufficiency. Opium becomes a hemostatic by subduing excitement. Cannabis Indica operates prob- ably in a similar way (I^. Tinct. cannabis Indies, .Ij. — Sig. 20-40 drops three times a day). It has been especially extolled in the hem- orrhaojes of the climacteric. Witch-hazel has been accorded a high position on the scale of uterine hemostatics in passive engorgement '" (I^. Extr. hamaraelis fl. — Dose, from a few drops up to 2 drachms). Among astringents are used gallic acid (gr. v to xv in pills or powder, t. i. d.), and alum (gr, x to xx, t. i. d., especially in the form of alum-whey, prepared by boiling 2 drachms of alum with a pint of milk, and straining. — Dose, a wineglassful, containing 15 grains of alum). Other drugs that are recommended for uterine hemorrhage are Viburnum pruuifolium (Extr. fl., 3j, t, i. d.) ; hydrastis Canadensis ' Garrigues, The Post-Graduate, Jan., 1887, vol. ii. No. 2, p. 117, and New Yorker Medicini.The PreHSc, Nov., 1886, vol. ii. No. 0, p. 231. ^ Chauncey D. Palmer of Cincinnati, O., Trans. Amer. Gyn. Soc, 1887, vol. xii. p. 182. TREATMENT IN GENERAL. 245 (Extr. fl., gtt. XX, t. i. d.), or hydrastiuinse liydrochloras (gr. J, in a capsule, four times a day); terebinthiua Chiensis (gr. vj, t. i. d.^); tinct. capsici (5 drops in a tablespoonful of* water every hour); smut of Indian corn (Extr. ustilagiuis maidis fl., 3j, t. i. d.), and the root of Caulophyllum thalictroides (5J-5ij of the infusion or decoction made with an ounce of the root to a pint of water, or .^j-3ij of the tincture made with four ounces to the pint), which both cause uterine contraction ; the nettle (Urtica urens and U. dioica, as decoction, sj to Oj of water. — Dose, a cupful several times a day) ; senecin (gr. i-iij), or extractum senecionis aurei fl. (3 i-ij, /. i. d.). Chlorate of potassium, given together with ergot, is also regarded with much favor. Very gratifying results have been reported of the use of the desiccated mammary gland of the sheep. The dose is from 3 to 6 tablets a day, each tablet containing 2 grains of the dry powder, and 3 of an excipient.^ In cases of uterine hemorrhage the bowels should be kept open, so as to avoid congestion of the pelvic organs. Sulj)hate of sodium, the old " sal mirabile Glauberi," a heaping teaspoonful dissolved in a little hot water every four hours till effective, answers a good purpose. When we see an exsanguinated person, we are tempted to give iron, but this drug should be carefully avoided during uterine hem- orrhages, which I invariably have found increase when any chalyb- eate is used. Even in the interval between the hemorrhages it has to be used tentatively, as it sometimes increases the amount of blood lost at the next flow. The same applies to alcoholic drinks. I pre- fer under such circumstances fii-st to use cotton-root, ergot, cinchona, and sulphuric acid, combined with local treatment and non-alcoholic malt preparations, until the tendency to bleeding has been overcome. Antipi/retics. — In acute cases there are often indications for reducing the temperature. If ice-bags and sponging with equal ])arts of cold water and alcohol do not suffice, recourse is had to antipyretic drugs, such as quinine (in 10-grain doses), salicylate of sodium (gr. xv), anti- pyrine (gr. x), phenacetin (gr. vii ss), or antifebrin (gr. v), repeated with two hours' interval. * J. R. Chaflwjck, Boston, Tram. Amer. Grfn. Soc., xii. p. 88. '.John K Sliober, Philadelphia, Amrr. Jour. Ohsletrm, Feb., 1809, vol. xxxix, p. 175. The tal)lets are made hy the Armour Company, of Chicago, and the H. K. Mulford Company, of Philadelpliia. 24(> DISEASES OF WOMEN. CHAPTER IV. Electric Treatment. Electricity is of great value in gynecology. The diiferent kinds of electricity and differently constructed machines and batteries have very different effects, and nnist, therefore, be considered separately. We distinguish between frankliniion, Jaradism, and galvanism, and, as a subdivision of the last named, galvano-cautcrization. 1. Franklinism, or frictionai elevtriciiy, is produced by rubbing a glass plate against cushions covered with amalgam. The patient may be insulated by sitting on a stool with glass feet, her body more or less filled with electricity, and sjiarks drawn from her by the ap- proach of a metal rod to different ])arts of her body. Another way of using frictionai electricity is by means of sparks and shocks from a Ijcyden jar. This kind of electricity is little used, and can hardly have any other effect than that of a stimulant in neurasthenia and of a counter-irritant in hyperesthesia and neuralgic pain. 2. FaracUsm, or indudioral e/edricitt/, is produced by leading the electricity generated in one or more voltaic cells, usually composed of zinc and carbon immersed in a fluid containing bichro- mate of potassium, sulphuric acid, and water, through a short coil of coarse insulated copper .wire called the primari/ coil, in such a way that the current is broken and closed at short intervals. The effect is much enhanced by placing a buu- dle of varnished wires of soft iron inside of the coil. Outside of the primary coil is another called the secondary/ coil, which consists of a much longer and finer insu- lated copper wire. The current going through the first coil is called the pri- mary current, and that induced in the second the secondari/ current. The primary current produces muscu- lar contraction, but the secondary, having the same effect in a higher degree, is in more general use for this purpose. One electrode may be applied in the uterus or in the vagina, the other on tlie abdominal wall over the fimdus of the uterus, or both poles may be Apostoli's Bi-poli\r Uterine niifl Va- ginal Exoitors: 1, small uterine; 2. medium uterine; o, lar^e ute- rine ; 4, vaginal, used in the ute- rus after confinement. TREATMENT IN GENERAL. 247 combined in one uterine or vaginal electrode (Fig. 214). The ad- vantages of the bipolar method are that it is less painful, the sensi- tive skin not being enclosed in the current, and that, consequently, a much stronger current can be borne. If the primary current goes through a thick and short wire, it has a great quantity of electricity ; and if the secondary current is in- duced in a very long and thin wire, it acquires a high degree of ten- ' sion} Such a current of tension lias great power in subduing pain (ovaralgia, abdominal pain in hysterical women, vaginismus, and pain arising from pelvic inflammations). It is also an emnienagogue. The faradic current is, as a rule, applied three times a week, some- times daily ; each sitting lasts from ten to thirty miuutes. The elec- trodes should be applied first, and then the current turned on very •slowly, the patient's feeling serving as a guide as to the strengtli applied. Finally, the current is gradually weakened and stopped before the electrodes are withdrawn. Tlie reason for so doing is that the vulva is much more sensitive than the vagina and uterus, and tliat a strong current is more endurable when it is increased and decreased gradually than when it begins and ceases suddenly. The cervix is also mucli more sensitive than the body of the womb. 3. Galvanism, or chemical electricity, is produced in a so-called battery, a combination of jars containing tiie elements and the exciting fluids. As strong currents often are needed, it is necessary to have a powerful battery.^ One of the electrodes is applied to the alidonien or, exceptionally, to tlie back. It ought to be very large, so as to distribute the current over a large surface, and thereliy diminish its density. Apostoli's'^ external electrode consists of wet clay^ in a bag of nmslin 10 or 12 ' Rockwell has constnuteil an apparatus which is made by the Jerome Kidder Manufacturing Company, 81^0 I'roadway, New York (Aow York Med. Jour., May 13, lS'J3i. With the latest iinprnveinents this battery consists of a fixed coil oif Xo. 21 wire, 02 to 05 feet lon<^, lor tlie primary current, and a movable secondary coil, operated hy a rack-muvcmeut. The total len<,^th of this secondary coil is 7,9ti2 feet, with the following suixlivisions : 72') feet of \o. 21 wire, tap|)ed at 252 and 474 feet; 2,574 feet of Xo. 32 wire, tapjied at 1,224 .-ind 1,350 feet; and 4,002 feet of Xo. 30 wire, tajjpcd at 1,032 and ;{,030 feet. The maciiine is provided with a circle-switch, allowing the .selection of the total length of the wire, or any part, iir any suhdivisiDU of any part, of the coil, and with a rheostat for modifying minutely tlie strength of the current. ' A battery of tbrly lai'ge I,eclaiich<' ctdis, i'a<'li with an electro-motor power of one and a half volts, or one of thirty acid cells, i ach producing two volts, is much used here. "Electricity has been u<ed in gynecolngy as long as it has existed as a s])ecial branch of medicine, and important woik li;is been dnue in this line also in this country by Kimball of Lnwell, Mass., Ilphraim Cutter of New York, .J. X. Ireeman and .John Byrne of Brooklyn, X. Y., and others. J{ul sinc(! 1SS4, Apostoli of I'aris has given this kind of treatment such au imjietus by o|)ening new and large lields for it, and introducing trreat improvements in its application, that his name is on all lips, and, therefore, this historical note may be pardoned as an exception. * In order to j)revent it from getting dry, it is a good jilan to add glycerin to the water fLapthornSmitii of .Montreal, .l/((<'r. .fmir. fjlj.</rt., .Vug., ISS'.t, vol. xxii. p. 7'JSj. 248 DISEASES OF WOMEN. inches long and 6 or 8 inches wide. It has the advantage of adapt- ing itself perfectly to the surface ; but it has the drawback of soiling physician, patient, and office, and may, therefore, advantageously be replaced by En(felmann''s electrode, which consists of a flexible plate of lead 7 by 6 inches, perforated with many holes and covered with punk and chamois ; or 3Iartin's electrode, which is a nickel-plated concave plate, 8 inches in diameter, covered with a membrane and containing a pint of warm water. The skin should be well moist- ened before the current is turned on, as otherwise a resistance is formed by the horny epidermis. It is an advantage to have the cutaneous electrode immersed in plain warm water. To add salt is not always good, although it aids in overcoming the resistance of the skin ; but when salt is used the sensibility increases, and consequently we cannot use such strong currents as without it.^ The inner electrode is, as a rule, applied in the cavity of the uterus all the way up to the fundus. Apostoh's intra-uterine electrode is made of platinum and shaped like a uterine sound, with a movable sheath of celluloid. This sound has the advantage of being incorrodible. It is, however, a disadvantage that it is stiff, has a tube hard to clean, and is very expensive. Aluminium cannot replace platinum, as it becomes corroded. I have had one made with a tip of platinum. No. 9, of the French bougie scale, 2 inches long, mounted on a brass rod covered with hard rubber (Fig. 215). The anterior part is bent like a sound, the posterior end split for the introduction of the tip of the rheophore. This electrode is very easy to introduce and to keep clean, and has given me entire satisfaction.^ The burning part being so small, it must, of course, gradually, both in the same sitting and at different sittings, be applied to different parts of the endometrium. The stiff electrode should be introduced without speculum after disinfecting the vagina.^ If the inner pole is applied to the vaginal roof, a ball of metal or ^ A. H. Buckmaster, New York, " The Galvanic Treat.ment of Fibro-rayomata," Brooklyn Med. Jour., Nov. and Dec, 1888. * It was made by Waite & Bartlett, 108 East Twenty-third street, New York. ^ In order to have the chemical cauterizing effect of the intra-uterine electrode, it has been calculated that it should present a surface of 1 square centimeter for each 25 milliamperes (F. H. Martin, Trcaw. Amer. Gyn. Soc, 1888, vol. xiii. p. 2751. Apostoli has a series of seven intra-uterine electrodes made of gas-carbon, which conducts readily, is little suVjject to the corroding action at the positive pole, and may be had at small expense. The length is the same in all, 1 inch, but the thickness varies from 5 to 12 millimeters (] to h inch) in diameter. They are screwed on an insulated metallic stem, the insulating sheath of which has a circular groove for every inch. This electrode is used in irregular and deep uterine cavities, and by withdrawing it from groove to groove the cauterizing eliect is extended from one part to the other (Apostoli, "Novelties," B7-it. Med- Ass., August, 1888, reprint, p. 26). TREATMENT IN GENERAL. 249 gas-carbon, one-half to three-quarters of an inch in diameter, mounted on a hard-rubber stem with central wire, may be employed ; but a thick layer of cotton should be wound around the bulb and made thorougiily wet. By so doing we avoid burning the vagina. The current is led from the battery to the electrodes by means of rheophores, flexible cords of fine copper wire covered with silk, Avith metal tips at the ends, which are easily adapted and kept in their place by a set-screw or by the elasticity of a cleft in the electrode. To measure the strength, or so-called intensity, of the current a milhamph'cmeter is needed, a kind of galvanometer, the scale of which should show at least 250 milliamperes. In order to be able to turn the current on and oif very gradually a collector, or a rheostat, is used. The collector is a differently con- structed metal contrivance which allows us to use as many or as few cells of a battery as we wish. It ought to be so arranged as to en- able the operator to include or exclude one element at a time. The rheostat is an apparatus that controls the current coming from the whole battery. The one I use consists of a hollow glass cylinder ^vith a wooden bottom, into which are inserted two set-screws for the rheophores. The posts connected with the screws lead the electric current through metal columns up to the metal cover of the cylin- der, in which cover a metal screw-rod turns, carrying at its lower end a cone of carbon, which is arrested on the edge of a well of Fig. 215. Garrigues' Intra-uterine Electrode. similar material placed at the bottom of the glass cylinder. This cylinder is partially filled with water. When the cone is out of the water there is no current, and by gradually immersing it the cur- rent becomes stronger, until the full strength of the battery is turned on,^ The current coming from a battery may be used as a constant or as an interrupted current. The latter cau.scs a shock and muscular con- traction, but is more or less painful, and with strong currents even dangerous. Bv using large and wet electrodes we chiefly get the interjwhtr effect, which is tliat oi' electroly.sis. By using small and dry electrodes we cliiefly obtain the polar eifect, which, when the cm-rent is strong 'The ahove-(lpscriho«l rheostat is that of the Galvanofaradic Company, Fourtli Avenue, near Twenty-third Street, New York. 250 DISEASES OF WOMEN. enough, becomes a chemical cauterization. By combining a large wet electrode on the skin with a small dry electrode in the uterus we avoid burning the skin and obtain the chemical cauterization of the uterus. Experiments on living animals have shown that when a galvanic current of 50 M. is applied to the intestine of a dog, the same be- comes blanched. Wlien it is applied to the heart, and the part en- compassed between the poles is examined under the microscope, the striic of the muscular fibrillar are found in a granular condition — a sign of beginning disintegration.' That the molecules are moved by the galvanic current can even be seen in a physical experiment. When a vessel is dK'ided into two compartments by a porous partition, and the compartments are filled to the same height with water, and a galvanic current is led through them, the water rises in that com])artment in which the negative pole is. This electric osmosi.s, or so-called cataphoresis, may be used for introducing drugs, such as cocaine or iodide of ])otassium, into the body by applying a solution of them to the anode.^ Different Qualities of t/ie Poles. — The two poles of the battery have different })hysical and physiological effects. The positive pole attracts acids, while alkalies collect at the negative. The eschar produced by the positive j)ole is dry ; that at the negative is softer, larger, and lets the galvanic current ])enetrate through it. Tiie positive is, therefore, used against hemorrhage and leucorrhea, the negative, where it is de- sirable to draw blood to the interior of the uterus and for galvano- puncture. The negative pole has a more pronounced denutritive effect. But if, in spite of these general rules, the expected effect is not obtained, it is advisable to try the other pole, and in the course of the treatment of the same case it is often indicated to change poles according to the changed circumstances. Apostoli's Method. — The ojieration may be performed in the pa- tient's home or in the physician's office. Sexual connection should be forbidden. Before operating with a battery with collector, the physician should try the battery in order to ascertain that there is no break in the cur- rent, which would cause a shock. This may be done by including one cell after the other in the current and watching the deviation of the needle of the milliampereraeter. The patient should remove her corset.^ She lies on her back, with her knees drawn up. If there are any erosions of the skin, they must be covered with collodium or paper before the electrode is placed 1 Buckniiibter. /. c, pp. 12-14. ^Frederic Peterson, "Electric Cataphoresis as a Therapeutic Measure," jN^. Y, Med. Jour., April 27, 1889. ^ In using Kngelmann's electrode it is enough to open the lower part of it TEEATMEyr IN GENERAL. 251 over them. Strict antisepsis is used in regard to hand, vagina, uterus, and internal electrode. The current should not be turned on until all pain caused by the introduction of the intra-uterine electrode has ceased. Then it is turned on slowly, so that it takes half a minute to a minute before the full strength is reached. In the beginning some pain is felt on the skin, due to the resistance offered by the epidermis. Then we wait till it has ceased before increasing; the streno-th of the current. The strength of current used varies according to the nature of the case and the sensitiveness of the patient. As a rule, an in- tensity of little less than 100 millianiperes is used, but -when there is a subacute inflammation of the parts situated near the uterus, and in hysterical patients, only 40 to 50 millianiperes can be tolerated Under all circumstances it is advisable not to go too fsir at the first sitting, but to stop, say, at 50 M. There must never be any severe pain felt in the uterus. In hirge uteri the intensity must be increased or the surface of the intra-uterine pole diminished. The current is kept up from five to ten minutes, in most cases only five. At the end it is turned off as slowly as it was turned on. The vagina is again disinfected, and the patient is directed to use antiseptic injec- tions the following days. The sittings are, as a rule, repeated on out-door patients once a week, but in more urgent cases twice a week : in private ])raetice the a})pIications are made two or three times a week. J3ut lieniorrhage may call for treatment every day ; and, on the other hand, Mhere there is perimetric inflammation, it may not be tolerated more than once in eight or ten days. As a rule, the applications are made in the intermenstrual period, but if there is severe hemorrhage, it may be necessary to operate immediately. Twenty, thirty, or more sittings may be needed to efl'ect a cure. Immedidte Effect. — Often some uterine colic is felt immediately after the treatment, and may last from a few minutes to several hours, or even till the next day. Sometimes the })atient may lose a little dark blood, and on the following days, when the eschar i,s being thrown off, there is always somesero-])uruleiit discharge. JOxception- ally, even enormous amoinitsof a watery fluid are discharged through the vagina. It is therefore by no means rare that the synii)toms, on the whole, get worse during the first five or six sittings before im- provement begins. Sometimes fever and other signs of iuflannnation may necessitate the tem])orarv interruj)tion of tlu; galvanic treatment. Chnaical (iahyino-cduterhdtioii of (he C'crvi.v. — .\))os(oli has con- structed a sj)ecial bi])olar electrode of carbon, to be used f()r cautei-iz- ing the cervix. It is used with strong currents (150 to 200 M.) for a very short time (two to ten seconds). The writer has obtained excellent results by using a milder current, 40 M., a longer time (five minutes), and a cari)on electro<le wound with very little, nearly 252 DISEASES OF WOMEN. dry cotton, forming; the positive pole, while the negative was an Eugelniann electrode applied to the abdomen (see Chronic Endo- metritis). Galvano-puncture. — If a tnmor is situated in the uterus in such a way that the sound cannot be made to enter the uterine canal, galvano- puncture is used. A trocar- or lance-head-pointed })latinum or gold needle is pushed through the vaginal roof into the tumor, and then connected with the negative pole of the battery. In inserting the needle care is taken to feel for and avoid j)ulsating arteries, and to push in such a direction as to reach the uterus. On account of the anatomical relation to the bladder such punctures cannot be made in front, but only behind and to the sides of the cervical portion ; and in the latter locality we must keep clear of the ureters and the uterine artery. Counter-pressure is made on the fundus through the abdom- inal wall. A fine needle should be used and introduced without spec- ulum. The introduction of the needle may be much facilitated by making it the negative pole of a mild galvanic current. The puncture is made on the point where the uterus bulges most into the vagina. The needle is not pushed deeper in than a quarter to half an inch. It is either used to form a communication with the cervical canal, so that, the artificial canal once made, the usual galvano-cauterization may be performed on the uterine mucous membrane, or the needle goes simply into the tissue of the uterus and perhaps a tumor situated in its wall. Hemorrhage may be stopped by interpolar action alone, without cauterization of the mucous membrane of the uterus. Galvano-puncture is a more serious interference than galvano-cau- terization of the inside of the uterus, and should not be repeated oftener than every eight or fifteen days. It has to be repeated several times before the canal remains open. It may be combined with posi- tive or negative cauterization according to indications. Upon the wdiole, galvano-puncture is more dangerous than other methods that will be described in treating of uterine fibroids, and cannot be rec- ommended. Thermal Gnlvano-cauierization. — The thermal galvano-cauterization differs from the chemical by using heat as the therapeutic agent. It is produced by another kind of battery especially constructed for the purpose. The principle is to produce a large quantity of electricity, which, being led through a comparatively thin platinum wire, that offers great resistance, heats the wire to incandescence. Two sizes of wire are used — a thin and a thick. The former forms a loop that can be drawn round and through a cylindrical body — c. g. the cervix uteri. The latter is shaped into knives and domes for cutting and burning.^ * The best instrument of this class is that of John Byrne of Brooklyn, N. Y., who has also constructed a special speculum for galvano-caustic operations {Clinical Notes on the Electric Cautery in Uterine Surgei-y, New York, 1873, and Trans. Amer. Gyn. Soc, 1892, vol. xvii. pp. 42-46). TREATMENT IN GENERAL. 253 By means of these galvano-eauteries diseased parts may be excised without loss of blood ; but in order to obtain this the knife or wire must never be brought to a white heat, and they should be carried slowly and interruptedly through the part to be severed. The knife should be applied cold, in order not to wound the vagina while intro- ducing it. If the wire loop cannot easily be ap])lied, a furrow may first be made for it with the cautery knife. When the wire has entered the submucous tissue, traction may be made with a volsella on the mass to be removed, so as to give to the cut surface the shape of a hollow cone. Thermal galvano-cauterization does not only present the advantage over other tnuteries (p. 187) that it can be applied with a flexible loop, but it has less radiating heat, and is, therefore, less liable to scorch the surrounding parts ; it seems to possess a power of modify- ing the tissue, even at some distance from the cut surface, by diffusion of the electricity ; and it has a powerful antiseptic effect, which appears clinically in the remarkable immunity from peritonitis, cellu- litis, and septicemia which distinguishes it from other surgical pro- cedures, and has been proved experimentally by direct aj^plication to germ-cultures. AVliere there are large masses of diseased tissue in the interior of the womb, it is often preferable first to remove some of them with the curette before using the galvano-cauterv. But then bleeding nuist first be stanched by irrigation with creolin, sponging, and the appli- cation of the cautery to ()j)en vessels. After that every })art of the cavity is gone over repeatedly with the dome-shaped galvano-cautery, and each time tiiat blood oozes from tlie seared tissues the cavity is to be sponged, until finally it is charred all over. The ragged bor- ders of the excavation should next receive attention, and no raw spot should be permitted to escai)e the cautery. Finally, the cavity and the vagina are tamponed with iodoform gauze (pp. 183—185). Dr. Skene has substitut(!d the combination of pressure and gal- vano-cauterization for sutures or clamps.' Metallic hderdllial Electrohji^h. — Under this name has been de- scribed a ])rocedure whicli in reality is a cataphoresis of drugs formed by the electric current itself Jiy using an intra-uterine electrode of cop- per, connected with tiie positive pole, oxychloride of copper is formed, and is, by the electric osmosis or cataplioresis, driven into the tissue. A current of" 20 to 30 .M. is used Cor from five to ten mijiiites. l)ui-- ing the ap|)li('ation the clectnKle siiould be kej)t in motion in order to avoid its sticking to the wall. If this, however, should hap|K>n, all that is needed to loosen it is to reverse the direction of the current for a few minutes. The cervical canal must be patulous for sul)S(!- ' Alexander, J. f\ Skene, of Brooklyn, N. Y., New Yurk Mid. Jour., .M;ir(li 27, 1897; Tram. Atncr. (Jyn. Soc, 1808, vol. xxiii. 254 DISEASES OF WOMEN. quent drainage, and it should, if possible, be excluded from the action of the copper. This treatment has proved very valuable in uterine hemorrhage and endometritis. A much stronger current, 80 to 100 M., has been used for ten minutes in the cervix for gonorrhea. After three applications all gonococci had disappeared. In a similar way zinc has been used. It forms an oxychloride, which has the property of softening the tissue, and has been used successfully in cases of sclerosis and fibroid. After having been used, these corrodable elec- trodes are polished with emery cloth.^ In 1898 the American Gynecological Society had invited four of its members, Drs. Geo. Engelmann, of Boston ; W. E. Ford, of Utica, N. Y. ; E. H. Grandin, of New York, and myself, to discuss the question of electricity in gynecology. Of the four papers, three were in favor of electricity as a therapeutic measure.^ ' A. H. Goelet, The Times and Register, 1893. pt. 2, p. 743. ■^ Garrigiies, " Electricity in Gynecology," Trans. Amer. Gynecol. Soc, 1898, vol. xxiii, p. 78, and Med. News, June 11, 1898. PART YII. ABNORMAL MENSTRUATION AND METRORRHAGIA. The normal process of menstruation has been considered in Part III. (pp. 117-122). This process is subject to disturbances which may occur in very different gynecological diseases or without any affection of the genitals. It may be absent {amenorrhea) or scanty ; the bleeding may take place from another part {vicarious men- struation) ; it may be painful {dysmenori-hea) ; it may begin too early in life {precocious menstruation) ; or it may be profuse {men- orrhagifi). Finally, there may be hemorrhage from the uterus at other times than the menstrual period {metrorrhagia). CHAPTER I. Amenorrhea. Amenorrhea is the absence of the menstrual flow, of which there are two varieties, suppression of menses and amenorrhea proper. 1. Suppression of menses is the condition in which the flow after having begun is suddenly arrested. Etiology. — The suppression of menses may be due to exposure during menstruation, by which the feet or the skin becomes wet and cold (compare p. 131) ; to emotions, especially a fright; or to the appearance of an acute inflammation, such as pneumonia or ery- sipelas. Symptoms. — The symptoms are sometimes slight or none, and tlie courses reapjicar at the next period ; but sometimes the sudden su])- pression of the menstrual flow gives rise to acute congestion or inflam- mation of the womb or the appendages, to extravasation of blood into the peritoneal cavity or the pelvic connective tissu(>, and tiie amenorrhea may last h ng or be final. Treatmenf. — It is pr'-j)er to try to bring the flow l)aek by hot a|>pli- cations to the alxlom in, hot hip-l)aths, hot vaginal and rectal injec- 256 DISEASES OF WOMEN. i tions; but, as a rule, this medication succeeds only in so far as it relieves pain. The same is accomplished by opiates. 2. Amenorrhea, in the. proper sense of the word, is the condition in which the menstrual flow fails to appear, although the patient has reached tiie proper age and feels as if she would be relieved by its coming, or where it does not reappear at the usual period in persons who have already menstruated. Etiology. — W^ have seen above that menstruation, as a rule, is absent during pregnancy and lactation. In persons who have never menstruated the cause may be congenital faulty development : absence of the ovaries and tubes ; absence or imperfect development of the uterus, such as a rudimentary or infantile uterus; absence or atresia of the vagina. Often, especially in young servants, the cause is over- work, sometimes combined with insufficient food. The causes may also be the same that are at work in making menstruation stop in those who have already menstruated. A common cause is a change of climate and habits. Thus amenorrhea is often found in women who move from the country to large cities, and in those who have recently immigrated from Europe. It is often a sequel of debilitating diseases, such as anemia, phthisis, malaria, typhoid fever, diabetes, or chronic mercurial poisoning. It is not rare in insane women and morphiomaniacs. It is sometimes found in the late stage of chronic metritis, in inflammation of the uterine appendages, in cases of malignant disease of both ovaries, or in women afflicted with a vesico-vaginal fistula. It is a frequent accompaniment of the devel- opment of obesity. About the effect of the removal of the uterine appendages see p. 1 21. Syinptoias. — The symptoms of amenorrhea, besides the absence of the flow, may be insignificant, but it is quite common that the patient complains of headache, flashing heat, heaviness in the abdomen, ner- vousness, nausea or vomiting, and sometimes she may even suffer from convulsions of the hysterical or epileptic type. If the non-appear- ance of the flow is due to atresia of the genital canal, the fluid accumulates behind the partition, considerable pain is experienced at each recurrence of the menstrual period, and a tumor is felt in the pelvis corresponding to the distended vagina, uterus, or both. The abnormal sensations occurring at the time of the menstrual period are called the menstrual molimen. Diagnosis. — The most important diagnostic question is if the amen- orrhea might not be physiological and due to pregnancy, normal or ectopic — i. e. outside the uterine cavity. In this respect every sign of pregnancy as taught in works on obstetrics must be thought of, especially the early signs, such as the softdning of the lower uterine segment, the increased diameter of the uteru.> in the antero-posterior direction, morning sickness, and small tongues of brown pigmentation ABNORMAL MENSTRUATION AND METRORRHAGIA. 257 shooting out from the superior external circumference of the areola, the first beginning of what is known as the secondary areola. In ectopic gestation we may, besides the signs of pregnancy, find a tumor outside of the uterus corresponding in size to the duration of the amenorrhea. Treatment. — Idiopathic amenorrhea should not be regarded or treated as a disease. In the beginning of menstrual life it is quite common that a period or two may be skipped. If the girl is other- wise well, no treatment is called for. If the cause of the amenorrhea is anemia, be it from loss of blood, from defective assimilation, or from wasting diseases, the only aim should be to ameliorate the general condition by proper alimentation, tonics (p. 242), moderate exercise in the open air, horseback riding, mild gymnastics, or massage. Aperients haV'C some influence in bringing on the flow, and the one most credited with emmenagogue ])Ower is aloes. In malaria quinine and arsenic are the chief remedies. If the nervous system is upset, bromides, antipyrin, or })henacetin is very useful. Hot vaginal and rectal injections, warm hip-baths, warm foot-baths with or without mustard, and long, warm general baths will sometimes bring; back the courses. The mere introduction of the sound works as a stimulus to the uterus, and may liave the same effect. Elec- tricity in all its forms (p. 246) is a powerful remedy, especially bijjolar intra-uterine faradization, witii secondary current, or, best, of all, galvanism, with the negative ])ole in the uterus. Besides iron, quinine, stryciminc, and aloes, the following drugs have more or less well-founded re|)utation as emmenagogue.^: Manganese in the form of the permanganate of potassium or tiie binoxide (gr. ij to iv, /. /. (1.)', chlorate of potassium (gr. v to xx, t. i. d.) in combi- nation witli iron ; santonin (gr. ij or iij, t. i. d.) ; oleum sabina3 (TTtiij to vj, t. i. d.); oleum ruttc (Tlliij to vj, f. i d.); oleum tanaceti (TTliij to vj, t. L d.) ; oleum hedeonue (THU to x, /. /. d.) or a warm infusion made of the herb; ergot (p. 243); radix gossypii (]). 244); tinct. cantharidis (TTtx, xx, uj) to foj, t. i. d.) ; tinct. hcllebori nigri (THxx to xl, t. i. d.) ; senecin, or fluid ('xtnK;t of" senecio (p. 245). As their effect is very uncertain, it is wise to combine several in one })re- scription — e. g. : I^. Strychninie sulj)h., ^^- } ', Aloes Socotr., 9j ; Quininte sulph., .^ij ; Fcrri sulphat. cxsiccat., Bij ; ()1. sabiuic, .^j ; Extr. gentian, co., q. s. Ft. pill. No. Ix. Sig. Three i»ill^ three; times a day. It is also well to combine the use of drugs with tiie other remedial agent.s recommended. 17 258 DISEASES OF WOMEN. If in cases of rudimentary uterus the development is so insufficient that there is no liope of help from electricity and the other remedies, and if the nervous symptoms are very distressing, the removal of the uterine appendages is indicated. If the apparent amenorrhea is in reality retention of the menstrual blood behind an obstruction in the genital canal, the removal of the obstruction by operations that will be described in treating of the diseases of the special organs, is the only means of saving the patient's life. Scanfi/ menstruation, the condition in -which the menstrual flow is insufficient in amount, is treated on the same principles as amenor- rhea, especially with tonics and electricity. CHAPTER 11. Vicarious Menstruation. Vicarious menstruation, or xenomenia, consists in the occurrence, at the time of menstruation, of bleeding from another part of the body than the uterus, or the appearance of another secretion. The vicarious bleeding may sometimes take place alone, instead of the nor- mal uterine monthly discharge, or it may be combined with it so as to be supplementary. In the latter case the flow from the normal source is generally scanty. Vicarious menstruation has been found to appear on nearly every mucous membrane and every part of the skin, the most common places being the stomach, the breasts, and the lungs. As to other secretions, serous diarrhea and increase of leucorrheal discharge have been observed to accompany or replace menstruation. I have myself seen colostrum in the breasts and profuse perspiration apj^ear at the menopause.^ Vicarious menstruation is a rather rare condition. It is mostly found in weak, nervous, hysterical women. Wounds, ulcers, and varicose veins ])redispose to it. Symptoms. — Generally tlie patient has both menstrual molimen in the pelvis and congestion, swelling, and pain in the place where the vicarious bleeding is to occur. Prognosis. — The importance of the affection depends on the nature of the locality affected. A bleeding from the skin or the nose is far less serious than that from the stomach and the lungs. In general the chances of stopping the abnormal loss of blood are good if we succeed in bringing back or increasing the normal flow. Treatment. — The treatment is chiefly directed to the relief of the amenorrhea or scanty menstruation (p. 257). The ectoj)ic bleeding calls only for treatment if it becomes excessive, and is then treated ' Garrigues, ximer. Jour. Obst., 1884, vol. xvii. p. 524. ABNORMAL MENSTRUATION AND METRORRHAGIA. 259 according to the general rules of medical and surgical practice. Dr. Frank V. Cantwell, of Trenton, N. J., in a case of excessive hema- temesis, accompanying normal menstruation, removed the healthy uterus and appendages, and obtained a perfect cure.^ CHAPTER III. Dysmenorrhea. Dysmenorrhea is the condition in which the menstrual process gives rise to pain in the pelvic organs. The pain may precede or accompany the flow. It may be due to diseases of the ovaries, the tubes, the uterus, the pelvic peritoneum, or connective tissue, or be of purely nervous origin. If the dysmenorrhea is due to inflammation of the uterine appendages and the contiguous part of the peritoneum and connective tissue, it apj)ears, as a rule, earlier — as much as eight days before the flow begins — and a relief is felt when the congestion is diminished by the physiological rupture of capillaries taking place in the mucous membrane (p. 119). The pain is situated in tiie sides of the pelvis or the iliac fossae. Sometimes it seems to be due merely to a toughness in the texture of tlie ovary which interferes with the free development of the Graafian follicle. If the aysmenorrhea is of uterine origin, it may be due to inflammation of the mucous meml)rane or the muscular tissue (en- dometritis or parenchymatous metritis). There may be an intra- uterine j)olypus playing the role of a ball valve, or the simple swell- ing of the nuu'ous membrane, esj)e('ially at the internal os, may pre- vent the escape of the blood from the cavity, or tiie uterus may be so bent that the crookedness of its canal opposes a barrier to the free outflow of the blood. It is especially anteflexion which predisposes to dysmenorrhea, but the more pronounced cases of retroflexion have a similar eflect. The cervical canal may be too narrow, especially at the internal or external OS (.sfoioslay Sfjinetimes clots are formed in the uterus, the exi)ulsion of which causes labor-like ])ain in the back and behind the symphysis. Sometimes the whole nnicous membrane is thrown off and expelled with similar ])ains — a condition called vinnhnniniis- di/smoiorr/icd. Uterine dysmenorrhea is felt more centrally and appears a shorter tiuK! before the app<'arance ol" the flow, and contiimes often for several days after it has begun. Tiiat dysmenorrhea which is due to closiu'e of the genital canal ' .!/•<■'/. Rrrorrl, Nov. 19. I SOS, j). 748. 2G0 DISEASES OF WOMEN. and retention of the menstrual blood has already been mentioned in the chapter on Amenorrhea (p. 256). Nervous dysmenorrhea may be due to over-sensitiveness of the nerves, so that the normal congestion of menstruation is perceived as a painful pressure, or it may be caused by muscular contraction of the internal os. The degree of dysmenorrhea varies from a slight discomfort to the most excruciating pain, that unfits the patient for any work and almost makes life unendurable. Pro(/nosis. — The prognosis varies, especially with the etiology. In most cases we may promise relief, if not a cure. Treatment — The treatment \'aries likewise very much with the causes. In young, undeveloped girls, without any inflammatory complications, mc try to avoid a vaginal examination. Even a rectal one may be dispensed with for some time. Tonics (p. 242), exercise in open air, gymnastics (p. 200), general massage (p. 199), towel baths, shower-})aths, and sea-bathing (p. 196) are the chief remedies. "Where there is any form of inflammation exercise can only be taken with great caution and Avithin narrow limits, and the patient ought to stay in bed during the attack. The treatment of the special diseases causing dysmenorrhea will be found under the description of the dis- eases of the dilierent organs, but for convenience's sake we will briefly refer to it here. In all inflammatory conditions we use hot vaginal injections (p. 175), painting of the vaginal roof with tincture of iodine (p. 174), pledgets with glycerin, iodine-glycerin, or ichtliyol-glycerin (p. 182), faradization with the secondary current (p. 246), galvanism or scar- ification of the vaginal portion (p. 194). In endometritis we make applications to the endometrium (p. 175). In anteflexion the regular use of the uterine sound gives great relief. A retroflexed womb is replaced and a Hodge's pessary intro- duced into the vagina. Outerbridge's intra-uterine drainage pessary (p. 191) mav prove useful. For flexions or mere stenosis the cervical canal is dilated with Hanks' and Garrigues' dilators (p. 157), either moderately (below half an inch) or to the full extent of the latter instrument (divulsion). The narrow canal may also be gradually dilated with the negative pole of the galvanic battery^ In cervical anteflexion it may become necessary to split the posterior lip of the cervix (Sims's operation). In desjierate cases of dysmenorrhea due to inflammation of the ovaries and tubes salpingo-oophoreetomy is the last resort. The purelv nervous dvsraenorrhea is treated with tonics and seda- tives (p. 242). During the attack all forms need some immediate relief. Since these conditions often last long and a baneful habit might be acquired, ABNORMAL MENSTRUATION AND METRORRHAGIA. 261 we should be careful not to abuse narcotics, but in bad cases they are unavoidable. I often use an anti-dysmenorrheic pill of the following composition : I^. Extr. couii ale, Bj ; Extr. strammon. ale, Extr. opii, da. gr. v. Ft. pil. No. X. Sig. One pill at most three times a day. In the milder cases hot dry or wet fomentations of the abdomen, and hot driid\S, such as hot tea or hot brandy and water or an infu- sion of anthemis or matricaria, may suffice. Antij)yriu (gr. x), antifebrin (gr, v), and pheuacetin (gr. viiss) should all be tried before narcotics are used ; and they have often splendid effect. If necessary, a second dose is given after an hour, and a third after three horn's. Viburnum prunifolium is also a uterine sedative : since the taste and odor of the fluid extract are most offensive to many ])atients, it is well to give it inspissated in capsules (dose 3j of the fluid extract, t. i. d.). Among the older drugs apiol (a capsule with TTLv from three to six times a day), ])ulsatilla (TTl.ij-iij of the fluid extract iu water, three or four times a day during the week preceding menstruation), and can- nabis Indica (20 drops of the tincture every three hours during the pain), are still praised. There is a widespread popular belief that marriage is a panacea for all a girl's sufferings, but nothing could be more erroneous. If marital relations may work as a stimulus, like electricity, to imper- fectly developed genitals, calm an irritated nervous system, effectually cure a stenosis or flexion, by the occurrence of conception and child- birth, on the other hand inflammatory conditions of the pelvic organs get much worse by the congestion ])r(xluced by coition and the stretch- ing of all the organs unavoidably connected with pregnancy and childbirth (p. l.'U). CHAPTER IV. pREcociors AM) Taiidy Menstruation'. A sixcjLE discharge of blood from the genitals is sometimes found in little ehildfen, even in the new-born, without any a|)])arent disease. Irregular bleeding may tak<! |)laee from a Siireoma. Hut we can only sjK'ak of pre(;ocious menstruation when there is a regular retinii of the bleeding from the genitals every four weeks in children bel(»w the age of puberty. This is a very rare afl'eetion. It has been 262 DISEASES OF WOMEN. observed in a child less than a year old, and several cases are on record dating from the second year. As a rule, both the external and internal genitals and the breasts are abnormally developed in such children, and sometimes they show sexual appetite. Their con- stitution suffers under the untimely loss of blood. There is nothing to be done for them excej^t to try to combat the general weakness, keep them quiet at the time of menstruation, and watch them in regard to masturbation. Perhaps clitoridectomy may put an end to the unfortunate habit. (See Masturbation.) To check the flow might lead to vicarious menstruation. Tardy menstruation is the first appearance of th(; menstrual flow at an unusual! V adv^anced ao-e. It has been seen to begin as late as thirty-one years. This condition has been considered under the subject of Amenorrhea. CHAPTER V. Menorrhagia. Menorrhagia is too great a loss of blood from the uterus at the time menstruation is due. The increased loss may either be due to a shortening of the intermenstrual period, or to a protracted duration of the flow, or, most of all, to an increase of the amount lost at each period. Since the normal amount is not known, and, at all events, varies much, we cannot indicate in an exact way where menorrhagia begins, but, practically, we call the flow so if it suddenly becomes much more profuse than the woman usually has it, and if it weakens her. Etiology. — ^Menorrhagia is in most cases due to a disease of the uterus, such as endometritis, chronic metritis, subinvolution, lacerated cervix, a granular condition of the os, a fibroid -tumor, a polypus, or cancer. It may also be due to the different kinds of dis{)lacements of the uterus. Secondly, it may be due to ovarian diseases, especially oo])horitis and small ovarian tumors. Thirdly, certain general acute infectious diseases are a])t to cause profuse menstruation, esj)ecially cholera, small-pox, scarlet fever, typhoid fever, and inflammatory rheumatism. x\mong the chronic diseases hemophilia, syphilis, chlo- rosis, and malaria especially give rise to profuse menstruation. Sometimes the cause is to be sought in diseases of the heart, the liver, or the kidneys. The menorrhagia not infrequently foinid in young girls at the beginning of menstrual life is due to anemia, that })revents coagulation of the blood in the capillaries, or to an overtaxed nervous system, which loses its normal control over the vasomotor nerves and the ABNORMAL MENSTRUATION AND METRORRHAGIA. 263 muscular tissue of the uterus. Similar causes are apt to give rise to a menstrual subinvolution in somewhat older girls, say between seventeen and twenty-four years of age, and this again is apt to result in menorrhagia.^ Symptoms. — Besides the increased loss of blood, there are other symptoms due to raenorrhagia. If the loss is very heavy, it may cause acute anemia with rapid, flagging pulse, dyspnea, pallor, cold clammy skin, faintness, or syncope. But oftener we find a chronic anemia characterized by pallor, weakness, asthenopia, and backache. Diagnosis. — The diagnosis between menorrhagia and metrorrhagia — i. e., uterine hemorrhage occurring independently of menstruation — is sometimes difficult or impossible when sucli frequent hemorrhages take place that the patient does not herself know what would be the regular time for a menstrual flow to come on ; but in most cases the distinction can be made by the time elapsed since the last bleeding, by the sensations which generally precede the menstrual flow, by the admixture of mucus with the blood, and by the gradual way in which the blood appears. Prognosis. — It is doubtful if ever a woman has died directly of menorrhagia, but repeated losses undermine health and shorten life. Treatment. — In the mildest cases Ave prescribe ergot and other internal hemostatics (p. 24-3), rest, cool diet, and abstinence from alcoholic drinks and coffee. The bowels should be kept open with saline aperients (p. 142). If there is any excitement, bromides and opiates, especially opium suppositories (p. 243), are indicated. If this treatment does not have tiie desired effect, vaginal injections with hot water may be added. If they do not check the hemor- rhage, we add liq. ferri chloridi to the water (p. 186). If the bleed- ing continues, an intra-utcrine injection of hot water with or without li(l. ferri is given (p. 176). Vaporization is effective ; but not with- out drawbacks and dangers (see p. 187). A bag with hot water applied to tht^ lumbar region is sometimes effective. An ice-bag is placed over the sympliysis (p. 195). If all this is ineffectual, or if the hemorrhage is alarmiiiii;, we tampon the vagina (p. 183) or the uterus (p. 185). In the intermenstrual period a treatment is instituted according to tlu! caus(! of the menorrhagia. If the endometrium is affected, the uterus is treated with a])plieati()ns of li<juor ferri ()). 175), curetted (p. 180), or eauterized by means of cliemical galvano-eauterization (p. 250), with the ))i)sitive pole in the uterus. (Jranulations are de- stroyed, a torn cervix united, a polypus removed, and a fibroid treated as taught under the (lis(;ussion of that disease. Ovarian ' W. H. Haker, address at the animal meeting of the Middlesex South Medical Society, April 20, 18'J8. 264 DISEASES OF WOMEN. inflammation is treated with injections, applications, resolv^ents (p. 243), glycerin pledgets, galvanism, etc. At the same time we try by means of hemostatics, tonics, and food to build up the patient as much as possible before the occurrence of the next menstruation (pp. 240-245). In cases of deficient nerve force and muscular contraction, faradization, hydrotherapy, sea- baths, general and local massage, gymnastics, and open-air sports are of the greatest value. In cases of heart disease a moderate bleeding gives relief, and should, therefore, not be checked too soon. Digitalis, strophanthus, and aconite are valuable remedies under such circumstances. When the liver is torpid, attention to diet, abstention from alcoholic drinks, and the administration of calomel, pulv. hydrargyri cum creta, or euouymin (gr. ss-v) are indicated. In kidney disease especial atten- tion should be paid to the vicarious functions of the skin and bowels. The physician must not forget that a moderate loss of blood is a normal condition, a kind of safety-valve, for the female economy. He must, therefore, allow a reasonable amount of blood to escape before he begins to check the flow. As a rule, I let patients suffering from meuorrhagia bleed from two to four days before interfering, but a dangerous loss of blood should be stopped at any time by the most potent measures. How to act in a given case can only be learned by tact and experience. If everything else fails to check menorrhagia, Tait recommends the removal of the appendages. CHAPTER VI. Meteorrhagia. Metrorrhagia is a profuse uterine hemorrhage occurring at another time than the menstrual flow. Its causes, symptoms, and treatment are essentially the same as those of meuorrhagia, just de- scribed, with the exception that this flow, being entirely abnormal, need not be allowed, and may, therefore, be treated more actively from the very beginning, unless the bleeding has a beneficial influence on some diseased condition — e. g. pelvic inflammation. CHAPTER VII. General Menstrual Disorders. The menstrual process being a general condition of which the secretion of blood from the mucous membrane of the uterus is oulv ABNORMAL MENSTRUATION AND METRORRHAGIA. 265 one feature, there is hardly any part of the body in which we may not find more or less important disturbances connected with it. These occur especially before the flow appears or in the beginning of the same. They may accompany a normal bloody discharge from the genitals, but are more commonly combined with amenorrhea or scanty menstruation. The Net'vous System. — Headache, especially in the shape of migraine, is quite common. Sometimes neuralgic pains are felt, especially in the arms and legs. Hysteria may be entirely due to menstrual disorders or get worse at every period. In exceptional cases it may reach the highest degree, so-called hystero- epilepsy. True epilepsy may only appear at the time of impending menstrua- tion, or the attacks may be worse every time the period recurs. In insane women the influence of menstruation is very marked. As a rule, maniacal attacks get worse or appear only at that time. Symp- toms of impulsive insanity, such as kleptomania or the impulse to murder, are sometimes decidedly increased by menstruation. The insanity of girls at puberty, especially that pyromania which drives them to set houses or hayricks on fire irrespective of consequences, may be parallelized with that of the menopause which we have already mentioned (p. 126). The Eyes. — Existing inflammation gets very frequently worse. In those suffering from exophthalmic goiter the eyes are more prominent. The condition known as hysteric copiopia^ acquires generally increased intensity. Blood may be extravasated into the anterior camera or behind the retina. Papillary inflammation, optic neuritis, neuro-reti- nitis, and complete amaurosis have been observed. The formation of sties is very common. The Ear. — Vicarious menstruation may occur from the ear. Exist- ing granulations swell ; purulent discharge, buzzing sound, and deaf- neas increase frequently. The Nose. — Profuse epistaxis may be due to vicarious menstruation. The skin is often the seat of exanthemata, such as acne, urticaria, eczema, exudative erythema, iier]>es, etc. The latter appears not infrequently on the genitals, which also are liable to become the prey ^ This disease, described by P'oerster, is characterized by pain in the region of tlie conjiiiictiv;il fold, in or Ix'hiiui the eye, the foreliead, less frequently in the inahir hones or the superior maxilla, and hy a peculiar kind of photophobia experienced in regard to artificial light in a dark room, ix'sides a great variety of hyperesthctic phenomena. It attacks both eyes. It is incurable, Imt disappears spontaneously, often after many years. It is frecpient in the higher classes, and is by far more common in women than in men. It is said in the former to be a retlex neurosis from chronic parametritis. As treatment it is recommended to let the patient take I draciim of Canadian castoreum and 1 drachm of extract of valerian in the course of four days, which gives relief for several wei'ks. At the .same lime the patient should u.se eve-<Irops with acetate of zinc (W. A. Frennd, GijnukobKjmhe Klinik, Strasburg, LSSo, vol. i. pp. 'J»;.")-272). 266 DISEASES OF WOMEN. of pruritus. The legs aud the face may become edematous. Some- times tliere is free pei*spiration, witli or without an unpleasant smell, or seborrhea of the scalp. Besides vicarious menstruation in the shape of blood trickling out through tissures forming in the skin, there are sometimes minute ee(;hynioses in the same. The Digestive Tract. — Sometimes the tongue is coated ; the patient suffers from toothache, aphthous stomatitis, or sore throat. As men- tioned above, the stomach may be the seat of vicarious menstruation, from a few teaspoonfuls to over two pounds of blood being vomited. There may also be a hemorrhoidal flow or diarrhea. In rarer cases a dull pain in the right hypochondrium betokens a congestion of the liver, which may even lead to jaundice. The Respiratory !Si/stem. — The thyroid body swells not infre- quently, especially in those afflicted with goiter, and this swelling may cause such a compression of the trachea that tracheotomy be- comes necessary. We have mentioned above that the lungs are one of the seats of ])redilection for vi(;arious menstruation. This hemor- rhage may be dangerous in itself, and may be a precursor of phthisis. The circulatory system does not suffer much, except that palpitations are not uncommon, and that angiomas and varicose veins are liable to increase. The Urinary Organs. — The sufferings due to floating kidney be- come Avorse during the congestion preceding menstruation. Tliere is a frequent desire to evacuate the urine, and the bladder may be the seat of vicarious menstruation. The Genitals. — Displaced ovaries may become particularly painful, and the swelling of the ovary enclosed in a hernia may give rise to strangulation. Fibi'oids often grow larger, aud intra-uterine polypi may be pushed down into the cervix or the vagina. In cases of atresia we have seen that the |)ain increases at each new outpouring of blood that finds no vent. Leucorrhea precedes or follows very frequently the menstrual flow, or appears, as stated above, as a sub- stitute for it. The breasts not uncommonly become swollen and painful, and they are one of the more frequent seats of vicarious menstruation. Patients affected with divers chronic diseases often feel more dis- comfort during menstruation. It is claimed that amenorrhea, with- out the presence of any other disease, may cause edema and ascites, and that menstruation has a very bad effect on the progress of osteo- malacia. Treutment. — In all affections connected with amenorrhea or scanty menstruation the first indication is to try to bring on or increase the menstrual flow, except in those cases in which there is a general deVjility that, presumably, would be made worse by any loss of blood. Under these latter circumstances the first thing to do is to strengthen ABNORMAL MENSTRUATION AND METRORRHAGIA. 267 the general health. Secondly, the different special disturbances call for treatment. Headache and neuralgia are often relieved by the administration of phenacetin, antipyrin, antifebrin, caffeine (gr. j to iij t i. d.), or the combination called effervescent granulated bromo-caf- feine (a heaping teaspoonful), pulv. paullinise (gr. xx, t. i. cL), extr. cannabis (gr. ^ to h, or 20 to 40 minims of the tincture, t. i. d.). A favorite combination of mine is phenacetin, caffeine, and sodium bromide (p. 243). In regard to the treatment of the manifold other disturbances men- tioned above we must refer the reader to works on the practice of medicine, special treatises, and later chapters of this Manual.^ ' Those familiar with German may find much valuable information in Leopold Meyer's Der Menstruation sprozess unci seine Krankhajten Abiveichungen, Stuttgart, 1890. PART VIII. LEUCORRHEA. Normally, the genital ti*act is just moist enough to be soft and slippery ; nowhere a drop of fluid is visible. Any mucous, serous, or purulent discharge is abnormal, and constitutes in itself a disease or is a symptom of one. The word " leucorrhea " means a white flow, but it is used to des- ignate any discharge other than blood coming from the genitals. Popularly the disorder is called " the whites." The discharge may come from the vulva, the vagina, the neck or the body of the womb. That from the vulva and the vagina is acid, that from the uterus alkaline. The microscope reveals flat epithelial cells in vulvar and vaginal leucorrhea, an abundance of mucous cor- puscles in the cervical, and columnar epithelial cells, sometimes cili- ated, in that coming from the uterus, be it from the neck or the body (p. 52), The fluid is serous, mucous, or purulent, and may have an admixture of a little blood. It may be colorless, white, yellow, green, red, or brown. The white color is due to the presence of epithelial cells, the yellow to pus, the red to fresh blood, and the brown to decomposed blood. The fluid may be nearly as thin as water or more or less thick like cream and soft cheese. A colorless, thick fluid like the raw white of an egg is exclusively secreted by the goblet-shaped cells found in the depressions between the branches of the arbor vitse (p. 51). Leucorrhea is idiopathic, specific, or symptomatic. A leucorrhea is called idiopathic when it is not due to any permanent structural ana- tomical lesion. It is then constitutional and forms a disease in itself. The specific leucorrhea is that due to gonorrheic infection. A leucorrhea is symptomatic when it is one symptom among others of a certain disease. Causes. — 1. Idiopathic Leucorrhea.^ — Like other catarrhal affec- tions, and often combined with them, it may be due to a cold, damp climate or residence. It may be connected with plethora or anemia. It may be induced by anything that weakens the constitution, such as protracted lactation, bodily or mental fatigue, emotions, es})ecially of a depressing kind, and insuflicient nourishment. It occurs fre- queiitly in persons predisposed to pulmonary phthisis. It is some- ' Fordyce Barker's paper, " Leucorrhea considered in Eelation to its Constitutional Causes and Treatment," Trans. Amer. Gyn. Soc, 18S2, vii. pp. 130-141, contains manv valuable hints on this topic, which has disappeared from many modern treatises on gynecology. 268 LEVCORRHEA. 269 times brought on by local irritation, such as masturbation, frequent coition, gravidity, childbirth, or abortion ; or it appears in consequence of amenorrhea or scanty menstruation as a supplementary or vicarious menstruation, not only during the period of menstrual life, but fre- quently after the climacteric has been established. In this way it may also take the place of lactation, suppressed perspiration, hemor- rhoidal flow, diarrhea, and other discharges. 2. The specific leucorrhea due to gouorrheic infection will be con- sidered under Vaginitis. 3. Symptomatic Leucorrhea. — It may be a symptom of rheuma- tism, scrofulosis, tuberculosis, malaria ; of numerous local diseases of the genitals, such as vulvitis, colpitis, endometritis, metritis, subinvo- lution, granulations at the os or in the interior of the womb, ulcers, a lacerated cervix, polypi, fibroids, sarcoma, carcinoma ; or of diseases in other organs which interfere with a free circulation in the genitals, such as disease of the heart and the liver. Si/mptoras. — The leucorrhcic discharge is a drain on the system, which lias given rise to the po})nlar belief that the Mhite stuff coming out of the genitals is the spinal marrow which melts. AVhile it may be brouglit on by anemia, it may also lead to it. The patients com- plain of weakness, backaelie, neuralgia in different parts of the body, and often an irrital)]e bladder. Commonly they sutler from anorexia and dyspepsia. Frequently there are menstrual disturbances, csj)e- cially too frequent, too long, and too copious menstruation, or, on the other hand, amenorrhea. Local changes in the cervix and the vagina, especially excoriations, ulcerations, granulations, and eversion of the mucous membrane, may be due to the irritation caused by the dis- charge, just as we find vegetations, eczema, erythema, intertrigo spring- ing up in the groins, at the vulva, and on the inside of the thighs. Prognosis. — Since leucorrhea is found under such extremely different conditions, nothing can be said in a general way about the prognosis. It depends mostly on the cause. Treatment. — The same aj)])lies to the treatment, but here we may add that, as a rule, a general and a local treatment should go hand in hand. The more the condition depends on constitutional causes, the more general treatment is needed, and the more successful it is ; the more local disease; predominates, the more actively must the leucor- rhea be comljated in its seat. The most substantial food and invigorating drinks that the stom- ach can digest nnist be given ( p. -40), and dig(;stion is to be helped artificially if necessary. Tlu- [)atient nnist liavc a movement of the bowels once in twenty-four hours. She must wear sufficiently warm clothes, especially woolen underwear (pp. l.'JO and 172). Toni(; medicines (p. 242), general massage(p. 199), gymnastics (p. 200), and exercise in the opc^n air, are useful. A great In^lp is found in change 270 DISEASES OF WOMEN. of climate, locality, and surroundings. The patient should, if pos- sible, be sent to a warm, dry climate or higli up in the mountains, but at the same time pleasant company should be provided. A cold and damp dwelling must be exciuinged for a dry and sunny one. Dif- ferent kinds of baths (p. 195) are to be recommended : warm hip- baths, tepid general baths, Turkish or liussian baths, are especially indicated where there is a rheumatic diathesis. Otherwise, it is better to strengthen the nerves and liarden the skin by means of towel-, sheet-, or sponge-baths, shower-baths, hydrotherapy, or sea- baths. Bicycling and lawn-tennis may answer a good purpose. In many cases of idiopathic leucorrhea a treatment carried out on these lines will suffice to effect a cure. This ought especially to be tried in intact girls, so that even a physical examination may be avoided. In most cases, however, recourse to local treatment is an impera- tive addition to the general treatment. Applications of tincture of tincture of iodine, solution of nitrate of silver, carbolic acid, chloride of iron, ferripyrine, chloride of zinc (20 per cent.), etc., are made to the affected parts (p. 174). If tlicre is no free drainage from the uterus, the cervical canal should be dilated (p. 157). Vaginal in- jections with hot water or astringents are beneficial in most cases (p. 175). It may become necessary to remove granulations from the cervix or fungoid growths from the inside of the corpus and fundus, by scraping the endometrium with the curette (p. 156), or to burn the cervical canal with the thermocautery (p. 187), or by means of thermic or chemical galvano-cauterization (pp. 252 and 248). The mucous membrane of the cervix may also be cut away. As to the special indications to be met in regard to underlying general or local diseases, the reader is referred to works on the prac- tice of medicine and to later chapters of this manual. Some internal remedies, such as aletris (cordial, 3j t. i. d.), hydras- tis (fluid extract, gtt. xx, t i. d.), cimicifuga (fluid extract, 3ss to 3j), inula (a decoction of the root, ^iij to water q. s. ad Biv, to be taken every morning), seem to have the special virtue of checking leucorrhea. In phthisical patients the leucorrheal flow is by some regarded as a kind of issue, to dry up which would precipitate tlie destruction of the lung. The local treatment should, indeed, be of the mildest or may be dispensed with altogether, but all the internal remedies rec- ommended, such as cod-liver oil, terraline, hydroleino,^ etc., only strengthen the whole constitution, and thus benefit the lungs indi- rectly, and the leucorrhea, if abundant, being in itself a drain on tiie physical strength, can hardly fail to have a bad influence on the pulmonary aft'ection. * Terraline is a product gained from petroleum. Ilydroleiue is a mixture of cod-liver oil, boracic acid, and other substances. I5otli of these medicines have seemed to me to have so decided an effect in wasting disenses that I do not hesitate to mention them here. DISEASES OF ^S\^0]SlEISr, II. SPECIAL DIVISION. SPECIAL DIYISIOK PART I. DISEASES OF THE VULVA. CHAPTER I. Malformations.^ 1. Absence of Vulva. — By an arrest of development in the first month of fetal life the external genitals and the anus may be absent, the skin covering the region uninterruptedly. (See p. 32.) This condition is almost always combined with arrest of development in other organs, and is only found in non-viable fetuses. If the anus is formed, liie may be continued without external geni- tals, the urine being evacuated through the navel. Such a case is on record, and wiis cured by tlie formation of an artificial urethra and closure of the opening of tiie urachus at the umbilicus. 2. Ili/pospadid.s. — In consequence of an insufficient closure in the median line the lower wall of the urethra may be split more or less deeply (Fig. 216). If tlie defect extends very deeply, so as to divide the ditfcrent spliincters of the urethra (p. 82), the patient cannot retain her urine. A small degree of hypospadias is, by far, not so important in woman as in man, and will hardly call for treatment. The complete congenital hyj)ospadijLS has been successfully treated by paring and uniting the surrounding nnicous membrane to such an extent as to form an artificial urethra, the relations of which to the bladder were much like those of a spout to a teapot." ' In this chapter T li.ivc to some extent used my article on tliis subject in Aiiirri- cxin Si/Klcm of (Ij/tirrnlDi/if, e<lifeil l>_v Marui, I'liiladelpliia, 1SS7, vol. i. pp. 'J.)")-l!SL'. ' For details the reader is referred to T. A. Emmet's (ti/iiccoloiji/, 'Jd ed., pp. »i49-C")t. 18 "" -7;i 274 DISEASES OF WOMEN. 3. Epispad{as.-^l£.Y>\spad\as (Fig. 217) is the name for the condi- tion characterized by a hick of union of the upper wall of the urethra. It is generally combined with a similar defect in the anterior wall of the bladder (e^i'troverslon). The clitoris and the symphysis pubis may be cleft or not. These defects are due to the intracorporeal part Fig. 216. Hypospadias (Mosengeil) : a, open canal, formed by the anterior wall of the urethra; b, pos- terior, closed part of tlie urethra ; c, entrance to vagina ; (/, hymen. of the allantois being pulled abnormally forward, becoming over- filled, and finally bursting. Epispadias, like hypospadias, has been cured by different plastic operations. One way is to form a transverse flap of the mucous membrane of the vestibule and stitch it to the meatus. Another is to denude two lateral surfaces and unite them in front of the o])en urethra. 4. Abnormalities of the Clitoris. — Sometimes the clitoris is split in two lateral halves, without any cleavage of the urethra or bladder, but in connection with a non-united symphysis and an opening in the abdominal wall above the bladder. Such cases are exceedingly rare. The cleavage of the clitoris is of no importance. The defect in the abdominal wall may be closed according to the general rules of plastic surgery. The clitoris may be absent or very small, or, on the other hand, as large as a medium-sized penis. This hypertrophy of the clitoris may be inconvenient, and can then DISEASES OF THE VULVA. 275 be remedied by amputation witli the galvano-caustie wire (p. 252), with the §craseur, or with Paquelin's thermo-cautery (p. 301). The prepuce is very frequently adherent to the glans, and in many cases this condition gives rise to reflex neuroses, even epilepsy and nymphomania. Treatment. — The vulva should be washed with bichloride-of-mer- cury solution. The child is anesthetized, or two or three drops of Fig. 217. Epispadias (Kleinwachtcr) : a, fissure in tlic bladder; b, labium majus; c, clitoris; d, labium minus; e, liynien ; /, vaginal entrance. a 2-per-cent. solution of cocaine arc tlirown into tlic glans clitoridis with a hypodcrniic syringe, and four or five drops more are thrown into the prepuce, li' one margin of the prepuce is then .seized with a pair of forceps, the thumb-nail will easily complete tiu; work of clearing the glans. Raw surfaces are sprinkled with iodoform and the prepuce packed with a little ball of iodoform gauze. As there 276 DISEASES OF WOMEN. is a marked tendency to recurrence of the adhesions, and the conse- quent nervous reflexes, this packing must be repeated every two or three days until the appearance of normal smegma shows that the mucous surfaces have developed sufficiently to take care of them- selves. 5. Abnormalities of the Labia Minora. — The labia minora may be absent. They may be multiple, each being split lengthwise in two or three flaps. They are sometimes too long, which is found phvsiologicallv in whole tribes. (See, for instance, Hottentot apron. This condition may interfere with coition, and may then be reme- died by cutting away the superfluous tissue and uniting the edges of tlie wound, which will heal by first intention. 6. Abnormalities of the Labia 3Iojora. — These may likewise be split by longitudinal clefts, so as to become double or triple. Alone or together with the labia minora they may extend so far back as to reach behind the anus, so that there is no perineum. 7. Epithelial Coalescence. — During the second half of fetal devel- opment the large and small labia may grow superficially together from behind forward. It is rare that the coalescence goes so far as to prevent micturition in the new-born child. Sometimes it may, how- ever, give an inconvenient direction to the jet of urine. Menstrua- tion may become difficult, and the small dimensions of the vulvar opening may oppose a serious obstacle to coition or childbirth. If the coalescence is combined with hypertrophy of the clitoris, the sex may become doubtful. Treatment. — The parts ought to be cut open in the median line on a director introduced through the existing opening, and kept sepa- rated during the healing process, or, if the cut surface is large, the edges of each side may be brought separately together by suturing. It is not rare that the urethra alone is agglutinated, so that the child cannot pass its urine. All that is needed in such cases is to introduce a silver probe into the bladder. Once opened, the canal stays open. 8. Hermaphrodism. — Hermaphrodism, or hermaphroditism, is the condition in which the characteristics of the two sexes become more or less blended in one individual. From the history of the development of the genitals we know that they are composed of three parts, each of which has its inde- pendent embryonal foundation — namely, the sexual glands, the two sets of ducts (Wolffian and Miillerian), and, finally, the external genitals (pp. 20, 22, 30, and 34). It is, therefore, not so difficult to undei"stand how one of these parts may be developed according to a sexual type diflering from that of the others. DISEASES OF THE VULVA. * 277 It is more difficult to understand how there can be more than one set of reproductive glands, for we have seen (p. 22) that it is one and the same body that, identical in the beginning, later becomes either an ovary or a testicle. But Avhile the connective-tissue part is identical in the two kinds of glands, ovary and testicle, it is not unlikely that the epithelial part of them has a different origin in the two sexes. Some anatomists claim, indeed, that the seminal canals in the testicle are formed as invaginations from the Wolffian duct, while we know that the follicles in the ovaries are derived from the germ- epithelium (p. 28). We know, furthermore, that we may have supernumerary ovaries (p. 122), and the same is claimed in regard to testicles, although it is infinitely rarer with them than with ovaries. Herraaphrodism is true or spurious. True hermaphrodism is that in which at least one ovary and one testicle are found in the same person. There may be found a complete double set of sexual glands — i. e. two ovaries and two testicles (true bilateral, hermaphrodiwi) ; or there might be found one sexual gland on one side, be it a testicle or an ovary, and on the other both a testicle and an ovary (true unilateral hermaphrodism), but it is somewhat doubtful if such a case actually has been observed or not ; or, finally, there may be one ovary on one side and one testicle on the other (true lateral Jirrmaphrodism). True hermaj)lirodism is at best exceedingly rare, and its existence is not even universally admitted. Spurious hermaphrodism, or pseudo-hermaphrodism, is that condi- tion in which the sexual glands belong to one sex, cither masculine or feminine, and the passages leading from them, as well as the exter- nal parts, approach more or less the otlier. S])urious hermaj)hrodism is subdivided into male or female according to tlie nature of the sexual gland. Each of these classes comprises three groups : the first is formed by those cases in which the ducts alone belong to the op])o- site sex [internal male or female pseudo-hermaphrodism) ; the second, by those in which tlie external ])arts alone re})resent the opposite sex {external male or female pseudo-her)na])hrodi.wi) ; and the third, those in wiiicli both the ducts and tlie external ]>arts approach tlie tyj)e of the other sex (internal and e.rtcrnal — or complete — male or female pseudo-liermaph rodism ). Pseu(lf>-hermaphro(lism, as well as true hernia])hro(lisin, is a mal- formation that dates from the earliest periods of i'oti\\ devclojtment. It is much more fre(|U('ntly found in the male than in the female! sex, and reaches also a nuicli iiighcr degree in the fonncr, so that a vagina, ut(^'rus, and tubes may Ik; found more or less developed in an indi- vidual with testicles, vasa def<'rentia, seminal vesicles, and male external genitals. The presence of menstruation does not settle the sex, since a periodical bloody discharge has even been observed to 278 ^ DISEASES OF WOMEN. take place from normal male genitals, and especially in males suffer- injr from hypospadias. The external genitals being formed in both sexes of the same sub- stance, it would seem impossible to have a double set of them, one male, the other female, although some portions may assume more the male; others more the female, type. Still, a case has occurred in which a woman who had recently given birth to a child presented in the median line, between an entirely normal vulva with clitoris and the anus, an erectile penis 2^ inches long.^ The general appearance of the body, especially in regard to the length of the hair, the development of the breasts, the prominence of Adam's apple, the breadth of the hips, and the angularity or rotundity of the form, presents a mixture of both sexes, the prepon- derance being, not with the real sex, as determined by the sexual glands, but with the external genitals. The diagnosis of the sex of hermaphrodites is often difficult, some- times impossible, in the living individual ; nay, even the pathological specimens, when examined after death, present so many deviations from the normal conditions that they are interpreted in a different manner by different observers of equal ability. When there is any doubt about the sex of an individual, it ought always to be declared a male. This will not only give it better chances to make a living and certain privileges in regard to political and hereditary rights, but it is also much safer to bring it up as a boy. A " girl " with a testicle can, if the sexual appetite awakens, do much harm in a boarding-school, and if it does not awaken she may marry without knowing that she, from a physical standpoint, is an unsatisfactory mate. Even otherwise well-informed physicians are apt to be led into error in regard to the determination of a per- son's sex, if they allow themselves to found their opinion upon such unreliable signs as the character of the voice and the presence of the mammarv olands." CHAPTER II. Ruptures (Hernia). Two kinds of hernise find their way into the labia majora — viz. the anterior, or inguino-lahial, hernia and the posterior, or vagino- labial, hernia . 1. The anterior labial, or inguino-labial, hernia in women corre- ' Franz Gebaiier, Centralbl. J. Gyndk., vol. xxiii. No. 5, p. 139, Feb. 4, 1899. * See Garrigues' "Supposed Hermaphrodite. — Sexual inversion," The Clinical Recorder, vol. ii. No. 2, pp. 4-7, April, 1897. DISEASES OF THE VULVA. 279 spends with the inguinal hernia in men, and is not very rare. It comes out through the inguinal canal, follows the round ligament, and descends into the anterior part of the labium majus. It may be found on both sides simultaneously (double inguinal hernia). At first it forms a round tumor in the region of the external abdominal ring ; later, when descending toward and into the labium majus, it becomes pear-siiaped. It may contain the gut, the omentum, the ovary, and the uterus, and when impregnation takes place even a fetus in the uterus. iJiagnosis. — When near the external inguinal ring, it may be mis- taken for a tumor of the round ligament, or hydrocele. In the labium it may be mistaken for an abscess, cyst, or tumor. As a rule, it will be possible to make the <listinction by paying attention to the history, by a resonant percussion-sound, by the increase in size caused by coughing and abdominal pressure, by the possibility of bringing the swelling back into the abdominal cavity through the inguinal canal, by the peculiar sensation of the gut slipping away under the fingers, by a gurgling sound heard during taxis, by the absence of local inflammation, and by the absence of fluid, or by the nature of the fluid when aspiration is made with a hypodermic syringe. Treatment. — The treatment is like that in the male — either by means of a truss, or preferably, by the radical operation. When the hernia is strangulated and cannot be reduce-d, herniotomy is im- jxTative. It may become necessary to extirpate an ovary found in the sac and, when pregnancy occurs in the imprisoned uterus, to perform Cesarean section, or, preferably, supravaginal amputation, or total extirpation of the uterus, A variety of inguinal hernia found in little girls is the hernia in the canal of the Xiich, corresponding with the hernia of the tunica vaginalis in the male. It is extremely rare. The treatment is the same as for other inguinal hernia?. 2. Posterior Labial, or Vat/i no-labial, Hernia. — This form is much rarer than the preceding. The escaping abdominal viscera here descend in front of the uterus, along the vagina and bladder, between them and the levator ani mu>;cle, and form a swelling at the posterior end of the labium majus. The course corresponds with the ascending branch of the ischium. It usually contains a part of the small intes- tine, but the large intestine and the omentum have also l)een found in it. Diagnosis. — It differs from anterior labial hernia by its positi(»n farther back, by the freedom from swelling of the sj)ace between it and tlie inguinal canal and of the latter itself, and by l)eing reduci- ble, not in the direction of the external inguinal ring, but in that of the vatrina. 280 DISEASES OF WOMEN. The diagnosis from other affections is made in th'e same way as just pointwl out for the anterior variety. Treatment. — It is hard to hold this kind of hernia back, but, as it may become very hvrge, tlie attempt should be made with vaginal pessaries, of which an inflatable rubber bag would be most likely to answer, or a truas. Once a surgeon obtained retention by denuding the mucous membrane in a circle round the lower end of the hernia, doubling it up and stitching it together ; after thus having thickened the integument covering it, it could be held back with a truss.' CHAPTER III. Tumors connected with the Extrapelvic Portion of the Round Ligament. In connection with the extrapelvic portion of the i"ound ligament may be found : 1, hydrocele; 2, hematocele of the canal of Nuck ; 3, hematoma of the round ligament ; and, 4, fibroma of the round liga- ment. 1. Hydrocele'^ is a swelling due to an accumulation of serum in connection with that part of the round ligament which lies in or below the inguinal canal. It is a rather rare disease. The fluid may be contained in the canal of Nuck (p. 37), or in the surround- ing connective tissue, or in the ligament itself. The space, if formed by the canal of Nuck, may yet comnmnicate with the abdominal cavity, or may be shut off from all connection with it by adhesion between its walls at the upper end. It is covered by the skin, the suj)erficial fascia, and the fascia transversal is. It is sometimes divided into several compartments. The fluid is, as a rule, serous and of a slightly greenish-yellow color, like serous collections in other parts of the body, but in traumatic cases it may be more or less bloody, and, when inflanunation occurs in the sac, it may become purulent and contain gas. It begins as a small, painless, oblong swelling in the inguinal canal, and extends in its slow growth down into the anterior part of the labium majus. It may be found on both sides. At first it often disappears when the patient lies on her back or when it is being compressed. If the fluid is found in a closed sac, the swelling is immovable, elastic, not very tender unless inflamed, and translucent, as the corrcs])onding affection of the tunica vaginalis in man. Jt may become as large as a child's head at tern), and may interfere with locomotion, render coition impossible, and opj)Ose a serious obstacle to childbirth. ' Winckel, Die Pathologie der Weiblichen Sexualorgane, Leipzig, 1881, p. 284. ^ A comprehensive article on this subject bv \Vm. C. Wile is found in Amcr. Jour. ObsL, 1881, vol. xiv. p. 584. DISEASES OF THE VULVA. 281 Diagnosis. — The diagnosis is sometimes difficult, particularly in re- gard to inguinal hernia. The characteristic points are the slow devel- opment ; the disappearance on pressure, if there is communication with the peritoneal cavity, without the sensation of any solid body being displaced ; the elasticity if the sac is closed ; and the translu- €ency. When inflamed, hydrocele may cause vomiting, but not con- stipation, as does a strangulated hernia. Treatment. — If the sac communicates with the peritoneal cavity, it may suffice to press it back and let the patient wear a truss until adhesion takes place between the walls. If the cavity is closed, simple aspiration has effiicted some cures. If that does not suffice, a few drops of tincture of iodine or ciarbolic acid should be injected after evacuating the fluid, so as to induce adhesive inflammation. During the injection the inguinal canal should be compressed, and the injected fluid should be sucked out again with the syringe. It may become necessary to make an incision, All the sac with iodoform gauze, and let it heal from the bottom by granulation. The whole sac has also been extirpated. If the contents of the cyst have become purulent or sanious, it nmst be laid open and thoroughly washed with disinfecting fluids (p. 217). 2. Hematocele of the Canal of Kuck. — If hydrocele of the canal of Kuck is rare, hematocele of the same is unique.' In the only case known it was of nine years' standing, and dated from childbirth. It formed a tumor of the size of a large hen's egg lying on the descend- ing ranuis of the left pubic bone. It was of tense, elastic consistency, without pain or tenderness on pressure, and covered by the skin of the expanded labium majus and minus, which was normal and mov- able. Its surface was smooth. It was not translucent, could not be diminished by pressure, did not increase during cougii, and gave a dull sound on percussion. From its upper end a ratiicr liurd pedicle could be traced into the inguinal canal. It contained a thick choco- late-colored mass of tiie consistency of an ointment. The wall was hard to cut through ; the cavity was entirely regular and smooth. Diagnosis. — It differs from intestinal hernia by the dull percussion, the immobility, and the laci-c of increase during cough ; from hernia of the orarj/ by its lack of sensitiveness ; from h i/drocclc by being less soft and l)y not being translucent ; from hemafoina of the vnlra bv the even surface and its clir()nic course, whereas hematoma of the vulva is soon al)Sorl)ed or forms an al)sc(!ss. Eliologij. — Injury (childbirth) in a person with a canal of 'Snvk the lower part of which lias remained oj)en, may cause an extravasa- tion of blood into that cavity. The ii-ritation of the foreign body <3auses the tiiickeiiing of tlie sin-rouiiding membrane. Treatment. — In the case on record a long incision was made, the ' Robert Koppe, V'nlnilblaUf. Gymik., 188G, vol. x. p. 17'J. 282 DISEASES OF WOMEN. contents turned out, the sac washed, cauterized, and left to heal by granulation. 3. Hematoma of the round ligament has likewise, so far, only been found once.^ It consists in a collection of blood in the interior of the round ligament. When operated on it had been noticed about four years. It formed a tumor in the right inguinal region of the size of a hen's e^g, and had been taken for a hernia. The surface was smootii, the consistency tense and elastic, the skin normal and movable over the tumor. From the uj^perend a pedicle lialf an inch in diameter could be traced into the inguinal canal. The tumor was not diminished by pressure, nor could it be pushed up into the inguinal canal. It gave a dull percussion-sound, and was not trans- lucent. An incision was made through skin, subcutaneous adipose tissue, and fascia, the tumor easily enucleated, the pedicle tied and cut off, and the edges united by interrupted silk sutures, without drainage-tube. The wound healed by first intention. The tumor prove<l to be a cyst, the wall of which was ^ inch thick. The con- tents were a dark bloody fluid. Microscopical examination showed that the wall was composed of longitudinal unstriped muscle-fibers, and that the fluid was blood. Diagnosis. — In regard to intestinal and ovarian hernia, hematoma of the vulva, and hydrocele we refer to what has just been said under Hematocele. From hematocele of the canal of Nuck it may, perhaps, be diagnosticated by the sensitiveness and pain found when the tumor is situated in the ligament, and consequently is dragged upon by any movement imparted to the womb. Treatment. — To what has already been said is only to be added that tlie pedicle ought to be comprised in' the sutures, so as to avoid a displacement backward of the womb. 4. Fibroma of the Mound Ligament. — The round ligament may become the seat of the formation of a fibrous tumor anywhere in its course from tlic horn of the uterus through the pelvis and the inguinal canal to the groin and the vulva. The situation outside of the inguinal canal is the most common. Tlie tumor appears first below the external inguinal ring, covering the inner third of Poupart's liga- ment, and extends by growth usually down into the labium majus, more rarely up through the inguinal canal and along the anterior abdominal wall up to the umbilicus. In the beginning it is more or less movable. It is hard, round, j)ainless, and covered with nor- mal skin. Sometimes a pedicle can be traced to the inguinal canal. It grows slowly, and has been found varying in size from a walnut to a cocoanut. Diagnosis. — The diagnosis is often difficult. From intestinal and ovarian hernia it differs by its hardness, lack of sensitiveness, and ^ Sigraund Gottschalk, CentndblaU f. Gyndk., 1887, vol. xi. p. 329. DISEASES OF THE VULVA. 283 lack of increase during cough ; from hydrocele, by its hardness and lack of pelhicidity ; from hematocele, by its hardness ; from hematoma, by its chronic course. Chronic inflammation or lymph o-sarcoma of an inguinal gland forms an immovable tumor, without pedicle, and affects, as a rule, several glands. Difuse fibroma of the vidva begins in the labia majora, and is immovable. Prognosis. — In itself innocuous, it may become troublesome by its size and situation. Treatment. — It is easily removed by an incision along its greatest diameter. The tumor is enucleated, the pedicle tied and comprised in the sutures unitins: the edires. CHAPTER IV. Injuries. The vulva may be tlie seat of bruises or wounds in consequence of a fall on some sharp object, for instance the back of a chair or the edge of a table, or of blows and kicks. The injury in such cases is mostly found on the labia majora. On account of the sharp edge of the ascending ranuis of the ischium and the descending ramus of the pubes, even contact with a blunt object may cause a clear cut. Coition seldom gives rise to traumatism of the vulva except in cases of rape. The fossa navicularis may, however, be penetrated, resulting in the formation of a permanent vulvo-rectal fistula.^ Cliil(h*en and old women are more liable to injury during sexual connection, on account of the lack of development in the former, and senile involution, with loss of elasticity, in the latter. Parturition is the most frequent cause of injuries to the vulva. Lacerations of the perineum will be considered later. Superficial tears of the labia majora are ([uite conmion, but need no special atten- tion, if my antiseptic occlusion-dressing is used.^ Sometimes a tear occurs in the vestibule, n^ar the clitoris, which may give rise to dangerous or fatal hemorrhage.' The sijinpfoins vary according to the cause and the degree of the violenre. If the skin remains imbroken, there are pain, soreness, swelling, discoloration, or perhaps subcutaneous extravasation of blood (pndenddl hrinafoma). The hematoma may consist in a swell- ing of the size of a hazel-nut or ac(|uire the dimensions of a fist or a fetal head at term. It is of dark blue or j)urple color and ' .loseph I'rice, Amer. Jovr. Ohst., IgSO, Tf.l. xix. p. 832. 'GarriKiies, Pmrtiml (hiiilc to Attli.vjitir Miihrifrtji, Detroit, Michigan, 188*'), p. 27. ■* Mund*'', Amn-. Jour. OhM., 187.'), vol. viii. p. •").'57. 284 DISEASES OF WOMEN. tender on pressure. The blood may be absorbed or the tumor may become inflamed, suppurate, and even fall a prey to gangrene. When inflanmiation sets in, swelling, tenderness, and heat increase ; the skin takes a brighter purple color ; the temperature rises, and symptoms of septicemia may develop. The swelling may oppose a serious obstruction to the passage of the child or cause retention of urine. It may also burst, causing the dangerous hemorrhage just mentioned. As a complication of delivery it has proved fatal in 20 per cent, of the cases reported. If the skin is broken, the hemorrhage is often alarming (p. 41). Treatment. — If the skin is unbroken, the pain is often best relieved by hot-water fomentations, to which may be added tinct. of arnica (3j to 5j). After that lead-and-opium stupes (tinct. opii, liq. plumbi subacetat., da 3j ; aquae, ,?viij) may be applied with advantage. If the hematoma is of so large a size that complete resorption is not to be expected, the best treatment is to apply Braun's colpeu- rynter filled with ice-water in the vagina, and compression on the skin for three or four days. When, then, the danger of hemor- rhage is passed, a free incision is made on the internal surface of the labium majus, parallel and near to its lower edge. The blood-clots are turned out, and the cavity washed out with antiseptic fluid, pref- erably creolin, on account of its hemostatic properties. If any vessels are seen bleeding, they should be tied with catgut ; or if there is oozing, the surface should be seared with the thermo-cautery. Next the sac is packed with iodoform gauze. The dressing should be renewed every day, and the cavity washed out with antiseptic fluid. If an abscess is formed, the pus should be given a free outlet by incision, and the wound treated antiseptically. A slight tear is dressed with iodoform ointment : I^. lodoformi, Bals. Pcruviani, da, 3J ; Vaselini, ,5j. — M. If there is any hemorrhage, a careful examination should be made for its source. Spurting arteries are twisted or tied. Bleeding sur- faces are brought into contact and miited by deep sutures. If this does not check the hemorrhage, the wound should be covered with styptic cotton (p. 186), the vagina tamponed (p. 183), and the ex- ternal genitals covered with compresses or a folded towel tightly fastened with a T-bandage. A fistula is treated by paring the edges and uniting them with silkworm sutures. If the contusion has been considerable enough to cause death of the tissue, the wound should be kept clean with an antiseptic solution, the dead tissue cut away as soon as feasible after a line of demarcation has formed, and the wound dressed with iodoform ointment. DISEASES OF THE VULVA. 285 CHAPTER V. Vulvitis. Vulvitis is inflammation of the vulva. It appears under five different forms : the catarrhal, the follicular', the phlegmonous, the venereal, and the diphtheritic inflammation. Etiology. — The causes of catarrhal and follicular vulvitis are lack of cleanliness, irritation produced by discharges from the uterus or vagina, or from the bladder if the patient is afilicted with a vesico- vaginal fistula; masturbation, excess in coition, rape; friction pro- duced by physical exercise in fat women ; pin-worms that find their way from the anus to the vulva, and ants that creep in from the skin. The scrofulous diathesis predisposes to the disease, especially in children. The phlegmonous form may result from the catarrhal or be caused by violence. It is mostly found in prostitutes. The venereal is due to infection with one of the three venereal diseases, gonorrhea, chan- croid, or syphilis. Tlie diphtlieritic occurs in childbed and in grave fevers, such as scarlet fever, small-pox, and typhoid fever. Symptoms. — The catarrhal vulvitis is either acute or chronic. The acute is more common. The mucous membrane is red, swollen, and covered Avith a muco-purulcnt secretion. Tliere is a sensation of heat and pain, especially smarting during micturition. In the chronic form the mucous membrane is of a less bright red color, and often the seat of abrasions or superficial ulcers. On the denuded places the papillae are hypcrtrophied and bleed easily. Redness and exco- riations are often found in the groin and on the inside of the thighs. Intolerable itching drives the patient mad, prevents sleep, and may easily lead to masturbation. Sometimes the glands of the groins swell, the lymphatics leading to them from the excoriatt'd patches becoming inflamed. In foUicjilar vnli-ifis the scat of the inflammation is in the hair-folli- cles, the sebaceous and sudoriparous glands, and, less fre((uently, the mucous follicles, the intervening mucous membrane remaining healthy. This gives a peculiar ap[)earance to the vulva, the labia majora and minora being studded with small round red j^rotuberances of the si/e of a millet-seed to a hemp-seed (Fig. 218). Often a hair comes out from the mifldic, and a drop of pus may be ])ressed out through the center. As a rule, the inflamed follicle bursts and shrivels up, but exceptionally the disease may end in induration, when small hard ncxlules remain after the inflammation has run its course. In phlegmonous vulvitis tin; iiiHammation extends to the submucous and sulx'Utaneous connective tissue. J)('('p abscesses and sloughs may form, aud end in permanent fistulous tracts if" not properly treated. 286 DISEASES OF WOMEN. Gono)'rheal vulvitis is much like the sini])le acute catarrlial ; but redness and swelling are more intense, the discharge is more purulent, Fig. 218. Follicular Vulvitis (Huguier). and the inflammation has a tendency to inij)licate the urethra, and is usually accompanied by gonorrheal vaginitis. ^licturition causes burning pain, the urethra is swollen and tender, and a drop of thick, creamy pus may be pressed out from it. In children the veins of the labia majora and minora are congested and varicose. The presence of gouococci may be revealed by the microscope. Valuable as these signs are from a diagnostic standpoint, they are not so pathognomonic that, called as expert in a lawsuit, the physician should not be careful not to be too positive in his as.sertions.' (See below under Vaginitis.) C/Mncroids and chancres will be considered under A^enereal Disea.ses. Diphtheritic vulvitis is characterized by the formation of a gray diphtheritic membrane on and in the mucous membrane or wounded surfaces. The surrounding parts are edematous, dark red, or other- wise discolored. In this form there is also high fever and general disturbance of the whole .sy.stem. Prognosis. — The acute catarrhal and follicular forms are of little ' The reader is referred on this point to the timely warning of so liigh an autliority as Kobert W. Tavlor, Atlas of Venereal and Skin Diseases, Philadelphia, 1888, pp. 57-58. DISEASES OF THE VULVA. 287 importance and short duration. The chronic form may be very pro- tracted. The gonorrheal may extend upward, and is then, as we shall see later, a very dangerous disease. The infective agent has also a tendency to remain in Bartholin's glands, and may thus cause infection long after the woman is seemingly cured. The phlegmonous form is rather serious. The diphtheritic form is only found as part of the most severe diseases. Besides endangering the jiatient's life, it may lead to more or less complete destruction of important parts, coalescence, and atresia of the genital canal. Treatmmt. — If the patient is feverish, she should be kept in bed, have a saline aperient and aconite ; in the diphtheritic form large doses of quinine and alcoholic drinks, and in the later stage tinct. ferri chloridi and strychnine. The genitals should be carefully cleansed, lukewarm or hot sitz-baths given two or three times daily; vaginal injections with carbolized water (p. 176) should be used as often. The genitals ^should be covered with fomenta- tions moistened with a weak antiseptic fluid. The genitals should be covered Avith fomentations of the same description, j)art of which should be applied between the labia. When the acutest stage is over the lead-and-opium wash may be substituted for the carbolic acid, or both combined. In tiie gonorrheal form hydrargy- riun bichloride is preferable ibr injections and fomentations (p. 17G). Later, the mucous membrane of the vulva may be painted several times daily with Monsel's solution of subsulphate of iron or the liq. ferri chloridi, each of them diluted with eight parts of glycerin. If this does not effect a cure, the inflamed ]>arts should be ])ainted every other day with a solution of nitrate of silver (gr. x— 5j) or tinct. iodinii co., diluted with two parts of water. When the nuicous mem- brane has nearly recovered, dry jxnvders, such as oxide of zinc, sub- nitrate of bismuth, iodoform, or even inert powdere, as lycopodium, talcum, or corn starch, often hasten the process. Tliese same powdei"s are used for the accompanying intertrigo. W the urine is alkaliue, benzoate of ammonium or sodium should l)e given (gr. x-xx every four iiours). When, on the other hand, the urine is too acid, bicarbonate of sodium or liijuor potassa' are indi- cated : I^. Tinct. belhulonn.ie, oij ; Li(l. potass., .^J ; Acpue, ad ^iv. M. Sig. A tcasjxionfiil in a wineglassful of water, /. /. <L In gonorrheal un'fhrifi.s tlu! uretln'a sliould be washed out with iiot water or flaxseed tea l)y means of a reflux catheter. WIhmi the inflammation subsides somewliat, carbolized water (.1 per cent.) or corrosive sublimate (j\j gr. to .5j), or nitrate of silver (^ gr. to .sj), oi- 288 DISEASES OF WOMEN. chloral hydrate (gr. x-5j), should be used. Pain may be relieved by instillation of cocaine with a glass pipette. If necessary, a few drops of a strong solution of nitrate of silver (gr. x to xxx-5j) may be in- jected or applied with an applicator through an endoscope. Fritsch's syringe is quite convenient for the injections. It consists of a hypo- dermic syringe and a silver tube with a small bulb at the end and perforated with several fine holes (Fig. 219). Antiblennorrhagic Fig. 219. Fritsch's urethral cannula. medicines (copaiva, cubebs, and sandal oil) should only be given in the subacute or chronic stage. ^Itching is relieved by chloral hydrate, camphor, or hydrocyanic acid : I^. Chloral, hydrat., 3j-ij ; Vaselini albi, §ij. — M. ^i. Chlorali hydrat., Camphorse, da. 3j ; Vaselini albi, §ij. — M. ^i. Acid, hydrocyan. dil., 3ij ; Plurabi acetat., 9ij ; Glycerini, §ij. — M. I^. Chlorali hydrat., Camphorse, da. 3ij ; Acidi oleici, lij. — M. When nothing else will help, the whole mucous membrane must be excised. In the phlegmonous form abscesses should be laid open by free incisions, washed out with disinfectants, and filled with iodoform gauze. Parts aiFected with diphtheritic infiltration should be cauterized with chloride of zinc dissolved in equal parts of distilled water.^ The healing process should be carefully watched, so as to avoid sec- ondary deformities. ' For the details of this treatment I must refer the reader to my other writings: " Puerperal Diphtheria," Trans. Ajiier. Gyn. Soc, 1885, vol. x. p. 109; "Puerperal Infection," Amer. Syst. Obst., ii. p. 363 ; Antiseptic Midwifery, p. 61. DISEASES OF THE VULVA. 289 CHAPTER VI. Inflammation of the Urethral Ducts. The urethral ducts described on p. 79 may become inflamed. Their mouths are then seen outside of the meatus in consequence of the swelling and prolapse of the mucous membrane. They appear like very small ulcers of a yellowish-gray color, surrounded by a deep-red circle, and a purulent fluid may be pressed out of them. The lower third of the urethra is sometimes swollen. It is exquis- itely tender to touch, and causes the patient much discomfort, but micturition is not particularly painful. Treatment. — The ducts should be washed out by injecting carbolized water or the saturated solution of boracic acid. If a more active treatment is needed, tincture of iodine or a strong solution of nitrate of silver (1 : 4) may be injected, or a fine probe covered with nitrate of silver in substance may be introduced into them. In a recalci- trant case I obtained a cure by introducing a probe and slitting the canals open from the vagina with Paquelin's thermo-cautery (p. 187). CHAPTER VII. Gangrene of the Vulva. The vulva mav become gangrenous in consequence of contusion, or overdistension due to edema or extravasated blood, or from the use of a tampon with undiluted liquor ferri chloridi (p. 184). Gangrene may also be caused by inflammation, especially diphtheritic infiltra- tion. It occui-s sometimes in ('ruj)tive fevers. An idiopathic gan- grene identical with noma is found in young children, and is said to \)c contagious. It begins as a white blister, which soon changes into an ulcer, that takes a diphtheritic aspect and becomes gangrenous. It is a dangerous disease, usually ending in septicemia. Treatment. — The afflrtcd ])iirt shoidd be cauterized with a 50 per cent, solution of chloride of zinc, oi* with the thermo-cautery, and covered witli iodoform or compresses dipjx-d into a saturated solution of chlorate of potash, 'iconics and stimulants should be used freely. As soon as a line of demarkation is formed, the dead tissue should be removed. 290 DISEASES OF WOMEN. CHAPTER VIII. EXANTHEMATOUS DISEASES. In exantheinatoiis fevers the genitals may be the seat of an erup- tion like other parts of the body. They may also be attacked by skin diseases, such as furunculosis, erythema, eczema, etc. ; but as these diseases offer nothing; peculiar in this region, and are treated as in other parts, the reader is referred in regard to them to works on the practice of medicine and on skin diseases. Only one exudative skin disease shall be described here, on account of its frequent occur- rence and great diagnostic importance — viz., herpes. Herpes Frogenitalis. — Herpes progenitalis is a mild inflammatory affection, consisting of one or more vesicles or groups of vesicles. The eruption may occur without any prodromal symptoms, but in most ca.ses it is preceded by a burning and itching sensation. First appears a small round red spot. On this the epidermis is soon raised, forming a vesicle of the size of a pin-head to a hemp-seed, filled with clear serum. This ruptures and leaves a shallow ulcer of the size of the vesicle. Its floor is at first of a deep rosy red, with a finely uneven surface and its edges siiarj^ly cut as with a punch, and sometimes undermined, but, as a rule, not to the same extent as in chancroid. Sometimes there is so much edema of the labia minora that the eruption is concealed until they are separated. On the skin the vesicle is followed by a scab. The disease lasts from a few days to two weeks, but is apt to return. It may lead to the development of a bubo. Etiology. — It is due to congestion and inflammation of the genitals and pelvic organs. It is only found in adults, especially in prosti- tutes. It appears often as a concomitant of menstruation. Diagnosis. — It may be very like a chancre in the erosive stage, but this has a deeper and duller red, coppery color, and its floor is smooth and shining, MMthout the small granulations found in herpes. Its areola is very slight and of a dark red color, and there is a gen- eral absence of inflammation about the lesion. On pressure a chan- crous erosion does not yield any fluid, while a herpetic vesicle gives issue to several drops. The history may also offer some help to a diagnosis, but it is advisable to be a little reserved until we see the course the disease takes. Treatment. — The parts should be cleansed and all irritation avoided. IVIildcr cases get speedily well when covered with lint soaked in — R. Acidi carbol.. mxi; Glycerini, 5ss; Aquse, ad 5iv. DISEASES OF THE VULVA. 291 The dry powders mentioned above (Vulvitis, p. 285) hasten the healing, and the iodoform ointment (p. 284) relieves pain. Persistent neuralgic and burning pains require cauterization with carbolic acid or a strong solution of nitrate of silver (1 : 8), followed by the lead- and-opium wash.^ CHAPTER IX. Trichiasis. Inversion of the hairs of the labia is a rare condition which causes intense itching. The offending hairs must be removed and their bulbs destroyed by electrolysis. CHAPTER X. Pruritus Yulv^. Pruritus vulvae is characterized by an itching sensation on the inner or outer surface of the vulva, sometimes extending up into the vagina or over the lower half of the abdominal wall. It may be symptomatic or idiopathic. AVhen it is symptomatic it may be a symptom of a disease of the genitals, especially follicular vulvitis, eczema pudendi, or trichiasis, or it may be a rcfiex symptom of disease in other organs, such as hemorrhoids, pin-worms in the rectum, diseases of the kidneys, ureters, bladder, or urethra, congestion of tlie pelvic organs, etc. Predisposinc/ canscs are pregnancy, menstruation, the menojxuise, old age, the gouty diathesis, or general nervousness. Sometimes the itching is due to direct irritation by parasites (lice or aearus seabiei), acrid disciiarges from the vagina or uterus, or urine containing sugar. In other cjises no cause, near or remote, can be found, and then it has been surmised that the disease is located in the tiervous centers. Symptoni.H. — The chief symptom is an itching that is so violent that it irresistibly drives the patient to scratch herself, a procedure which gives a momentary relief, paid for by increased itching. The scratch- ing pnxluces excoriations and intlanimatory conditions, especially (K!zetna, which, again, contribute to the morbid sensation. ' For further details the reader is refcrre<l to Robert W. Taylor's ,!//'/.•< ';/' Vfinifdl and Shin Dmcu^ex, Philadelphia, 1S8S, p. 7'J. 292 DISEASES OF WOMEN. In its higher degrees the disease is a very serious one. The patient scratches so that she wears off the liair of the mons A^eneris and Libia niajora ; she avoids company ; she becomes melancholy and morose ; she loses her appetite ; her sleep is disturbed ; she becomes the victim of an abnormally increjised sexual desire or contracts the habit of masturbation ; she may finally become insane, succumb to exhaustion, or end her miserable existence by suicide. The itching may be continuous, but is more frequently interrupted by free intervals of hours and days. It increases by heat, and is, therefore, worse at night, in a warm room, and during physical exertion. Prog)iosis. — The prognosis depends on the possibility of removing the cause. If no cause can be found, it is often very obstinate, and sometimes, it would seem, incurable. Treatment. — First of all, we must try to find and remove the cause. If there are crab-lice among the hairs on the pubes, the hairs should be cut short or shaved off, and the skin smeared with blue ointment or balsam of Peru, or washed with a strong solution of corrosive sublimate (1 gr. to alcohol and water ad. .^ss), and general warm baths with 2 drachms of the same drug should be given. If the acarus scabiei is the offender, as a rule a treatment for itch of the whole body will be needed. Locally, beta-naphthol in vaseline (gr. XXV to 5J) or sulphur ointment should be rubbed in. Inflammation of the vulva must be treated as described above (p. 279). Eczema is treated with unguent.diachyli. Pin-worms are removed from the rectum by means of extr. sennse et spigeliise fl. (.sss, t. i. d.), given by the mouth, and rectal injections of a strong infusion of quassia (.lij-Oj) or corrosive sublimate (gr. | in .oviij of water). Hemorrhoids, glycosuria, and other diseases causing the pruritus should be treated according to the rules of medical and surgical practice. The diet is of great importance. Besides the special diet called for by diabetes and gout, alcoholic drinks and spiced food should be avoided. The food should be nourishing, but bland. ]Milk in large quantities (two or three quarts a day) is to be recommended if it can be digested. If it «uises dyspepsia in its natural state, it should be tried boiled, skimmed, or peptonized. The general treatment should be tonic, sedative, and narcotic. Arsenic and quinine are particularly recommended. Bromide of potassium in large doses (oj-ij daily) is often very valuable. Tinct. cannabis Indica (20 to 40 drops, t. i. d.) is preferable to opium. It may be necessary to procure sleep by means of chloralamid, suljihonal, urethane, trional, or the other modern hypnotics (p. 24.">). The local treatment is of the greatest ini{)ortance. Vaginal injec- tions and affusions of plain hot water, solutions of carbolic acid, DISEASES OF THE VULVA. 293 bichloride of mercury, or borax should be freely used many times a day. If any irritating discharge dribbles from the vagina, relief is obtained by keeping it back by means of a cotton tampon wrung out of some mild antiseptic solution. The vulva may be covered with fomentations of lead-water with or without opium or the saturated solution of potassium bromide, or painted several times a day with glycerin mixed with chloroform (8:1), hydrocyanic acid (p. 288), or morphine (gr. ij or iij to 5J) ; or the parts may be painted at longer intervals with a 10 per cent, solution of cocaine in water, or a simi- lar solution of carbolic acid, followed by cold applications. For base of ointment vaseline is the best. It may be mixed with acetate of lead, chloral, camphor (p. 288), or chloroform (of each 3j-§j). The affected part may be rubbed with a menthol stick or solid nitrate of silver. In nearly every case 1 have obtained a cure by painting the whole inside of the vulva two or three times a week witii a solution of nitrate of silver (5 per cent.) and letting the patient use the wash comy)osed of lead, hydrocyanic acid, and gly- cerin (p. 288), on fine muslin, changing it half a dozen times a day. In cases complicated with diabetes this treatment docs not cure, but even then it gives considerable relief. Some claim to have success- fully applied the galvanic current.' As a last resort, when every- thing else had failed, the removal of the affected portions of skin or mucous membrane by cutting instruments has effected a cure in several cases. During pregnancy only the milder of the al)ove-named remedies may be used. Large and frequent vaginal injections must be avoided. A tampon soaked in equal parts of sulphurous acid and glyceratum boracis may be introduced into the vagina. One case is reported in wiiich tobacco-smoking gave relief. Burnwfj Sensation in t/ic Genitah mid the Abdomen. — This affec- tion is probably nearly related to pruritus, but dili'ers from it in the character of the sensation. It is not very rare — in my experience, if anything, more common than its universally recognized sister, and still itself is hardly mentioned anywhere. It seems to be fully as recalcitrant to treatment, if not more so. Applications of c()ni])resses soaked in cold water to the abdomen, the above-mentioned vaginal injections, and bromidi! of ])otassium internally have given me the best results. ' W. Blackwood, PohjcUnic, Philadelphia, 1885, No. 9, vol. ii. p. 141. 294 DISEASES^ OF WOMEN. CHAPTER XI. Hyperesthesia of the Vulva. Dr. T. G. Thomas has described, under the name of hyperesthesia, a disease of the vulva that is sufficiently well marked to deserve a special place in the system of gynecological diseases.^ Although by no means frequent, it is, according to him, not a very rare disease, either. It consists in an excessive sensibility of the nerves supplying the mucous membrane of some part of the vulva. The slightest friction excites intolerable pain and nervousness ; even a cold and unexpected current of air produces discomfort; and any degree of pressure is absolutely intolerable. Sexual intercourse is, therefore, hateful or impossible — a condition elegantly called dys- pareunia (p. 123). Tiie disease appears near or at the menopause ; hysteria and despond- ency predispose to it. Sometimes it is found combined with vulvitis or a painful urethral caruncle, but in other cases no cause can be found. It differs from pruritus by the absence of itching, and from vaginismus by not causing any spasmodic contraction of the vagina. The treatment is unsatisfactory. Even the complete destruction of the mucous membrane of the sensitive area with caustics or its removal with the knife has failed to })roduee a permanent cure. Sexual intercourse should be absolutely forbidden. If feasible, the patient should be sent away from home to a place offering healthy surroundings and cheerful company. The general treatment should consist in tonics, sea-baths or M-arm general baths, and massage. The local affection siiould be treated with hot sitz-baths, injections, and affusions, and calmative, astringent, and derivative applications, as detailed in the preceding chapter. CHAPTER XII. Tumors of the Yulva. 1. Hyperplasia. — Without containing diseased tissue, parts of the vulva may acquire abnormally large proportions. Thus we have seen that the labia minora in certain races become enormously developed (p. 37), and that in some individuals the clitoris may have the size of the male organ (p. 274). ' T. Gaillard Thomas, A Practical Treatise on the Diseases of Women, 6th ed.-, Philadelphia, 1891, p. 150. DISEASES OF THE VULVA. 295 2. Varicose Veins. — The veins of the vulva, especially of the labia majora, may swell so as to ibrm tumors of considerable size, even that of the fetal head. This condition is in most cases connected with pregnancy, but may occur independently thereof. It is produced by everything that obstructs the free flow of venous blood from the vulva, such as tumors pressing on the pelvic veins, lifting of heavy burdens, pro- tracted standing, habitual constipation, etc. The swollen veins form dark blue, nearly black, globular, oval, or serpentine soft swellings, that collapse on pressure, and refill immedi- ately when the pressure is discontinued. They increase during preg- nancy, and become smaller after the birth of the child ; but often they do not disappear altogether. They cause an uncomfortable sen- sation of heat and weight, especially during bodily exertion, and sometimes pruritus. They may burst spontaneously, but usually that accident is produced by the passage of the child or by external injury. If the skin holds, a hematoma is formed ; if it breaks, a serious, and sometimes fatal, hemorrhage follows (p. 41). Treatment. — During ])regnancy the ])atient should rest in a recum- bent position in the middle of the day, in order to relieve the pressure of the child on the veins of the pelvis. At times even complete rest in bed or on a lounge is indicated. Fomentations with lead-water relieve heat and tension. A pad may be adapted in such a way as to compress the swelling. The patient should be informed of the dangei-s of hemorrhage, and instructed how to check it by compression till she can get helj). AVhen a rupture has taken place and the blood escapes, the hemorrhage should be controlled by means of deep sutures, tamponade of the vagina and vulva (pp. 183, 184), combined with ])ressure on the skin by means of a compress rolled so as to form a hard cylinder placed against the cutaneous surface of the labia majora and retained with a T-bandage. 3. Hnnafoma, or thmmhus, is a swelling due to extravasation of venous blood in the connective tissue of the vulva. It is most com- mon in the labium majus, and, as a rule, it affects only one side. Varicose veins predispose to iiematoma. The exciting causes are external violence, such as a blow or a fall, and straining, esjiecially during childbirth. (See p. 283.) 4. Papilloma is a tumor produced by hyperplasia of the pa])ill8e of the skin or nnicous nicmljranc, with corres]X)nding develo])uu'nt of the blood-vessels and epidermis. It appears on the female genitals in three well-marked forms: common wartx, vegetations, and vikcoiis patches. Warts, generally of round form, more or less pediculated, of the size of a j)ea or a i)ean, witii a dry, uneven surface of dark brown color, are oc(y»sionally found on the skin of the vulva, especially the 296 DISEASES OF WOMEN. mons Veneris, as in other parts of the body. They are insignifi- cant, and do not call for any treatment. Vegetations, also called venereal warts or condylomata acuminata, stand in special relation to the genitals, male and female. They are often found in patients suffering from gonorrhea, chancroid, or syphilis, especially gonorrhea ; but they may also be entirely indej^endent of any venereal atfectiou, and are then due to lack of cleanliness or to friction. They are most common on the fourchette, at the vaginal entrance, and the labia minora or majora, but may extend through the whole vagina and to the vaginal surface of the vaginal portion of the uterus, the inside of the thighs, and around the anus. On the mucous mem- brane they are soft ; on the skin they are harder. They begin as small erosions, which soon change to pin-head-sized granular papules. After that they grow rapidly, forming sessile or pediculated, club- or cockscomb-shaped protuberances. Their color varies much : some are light gray, others are pink, deep red, or purplish. They vary in size from a hemp-seed to a raspberry, but if neglected the different isolated growths come in contact with one another and may form a tumor as large as the fetal head. Their surface shows always pro- tuberances separated by deep furrows, and they can be separated into smaller cauliflower-like parts springing from a narrow base. They exhale a mucoid secretion of a sickening odor. Even the dry vege- tations on the skin are apt to become eroded and secrete such fluid. The acrid secretion may cause vulvitis and vaginitis, and the tumors may mechanically obstruct the meatus urinarius, the vaginal entrance, and the anus, so as to interfere with micturition, coition, defecation, and childbirth. When they are destroyed new ones are very prone to spring up. In elderly persons they have a tendency to become malignant and change into epithelioma. The secretion, if carried into the eyes, is apt to cause purulent ophthalmia. During childbirth there is the same danger for the eyes of the baby, and besides that the risk of puerperal infection of the mother. The tumors may also become gangrenous, and in that way cause the patient's death. Diagnosis. — Flat and broad vegetations may sometimes be so like mucous patches that one affection may be mistaken for the other ; but with mucous patches we have the history of preceding syphilitic infection and, as a rule, other concomitant symptoms of syphilis. They are few in number, and develop more slowly. Treatment. — The sooner these tumors are removed the better. If they are small, they may be snipped off with curved scissors or scraped off with the sharp spoon, after which the base should be touched with liq. ferri chloridi or the actual cautery. They may also be destroyed with corrosive-sublimate coUodium (oSS-.lj) or sali- cylic acid dissolved in collodium (.^j-.lj), glacial acetic acid, lactic, nitric, or chromic acid, and other caustics. The tincture of Thuya DISEASES OF THE VULVA. 297 occidentalis is said to be a specific for these growths. They should be constantly moistened with it. In my experience the thermo- cautery and nitric acid have given the best results. If the tiimors are of medium size — up to an inch in diameter — they may be tied with a silk or rubber ligature. If they are still larger, the galvano-caustic wire is the best means for their removal. At the same time, great cleanliness should be inculcated. Vaginal douches with carbolic acid or corrosive sublimate, hot sitz-baths, and hot affusions should be used several times a day. The affected sur- faces should be kept dry and separated with antiseptic gauze. If operation is contraindicated, even large tumors can be made to shrink by covering them with equal parts of calomel and salicylic acid.^ If these vegetations have invaded the meatus urinarius, care must be taken to use methods that will not cause stricture. Even during pregnancy vegetations should be removed by some of the above-named means, since they ])resent a double danger for mother and child. Minor operations may be performed with cocaine (1 : 8 or 10); the larger require general anesthesia. Mucoiis patches will be considered later. The disease which has been described under the name of oozing tumor is probably a kind of papilloma. It is a very rare disease, if it is not simply the same as large fiat vegetations. It is said to occur mostly in middle-aged fat women. It forms a large fiat tumor on one or both labia majora, divided by deep fissures, and is char- acterized by discharging a large amount of an acrid, offensive fluid. In a case operated on by Dr. Emmet ^ with knife and sutures the hemorrhage was profuse. It is therefore preferable to remove the mass with the thermo-cautery or galvano-cautery. 5. Elephantiams, or jxtchydermia, is a chronic recurring inflamma- tion of lymph-ve&sels accompanied by hyperplasia of the connective tissue, the skin, mucous membrane, and epidermis, leading to the formation of large tumors. Etioloffy. — Sj)oradic eases are very rarely found in North America and I]urope, but the disea.se is endemic in the West Indies, the coasts of Central and South America, Africa, and on the islands of the Pacific. It is mostly found in adults, but seems to begin in child- hoo<l. The dark races are much more frequently affected than the white. It occurs especially in marshy localities. It is mostly due to the presence of a jmrasite called fi/firia saiupdnis in the bloo<l, in which it is sup])()sc(l to Ix' introduced through mosquito-bites. It may also be due to ])rimary occhision of lym])hatics and destruction of the lymphatic glands of the groin. HymptoiiiH. — The endemic form begins with all the symptoms of ' i:. W. Tavlor, /. c, p. 30. » L. c, p. 003. 298 DISEASES OF WOMEN. lymphangitis. The patient is feverish ; the affected part becomes swollen and red ; the redness may follow the lymphatics or blood- vessels as red streaks, or cover the whole surface as in erysipelas. The inguinal glands become swollen and tender. This acute stage lasts a week or two, subsides slowly, and leaves often the parts in an ede- matous condition. After that there follows a free interval varying in length from a month to several years, when the same process is repeated, each attack leaving the affected part more swollen and harder, until all pitting ceases and the tissue becomes hard as the rind of ham. The skin has a dark color. The surface may be smooth or rough, covered with warts, the seat of fissures, or, when the tumor is rubbed, ulcerations may form and allow a serous fluid to ooze out. Most frequently the labia majora are the seat of the dis- ease, after them the clitoris, and most rarely the labia minora. The tumore may reach such a size that they hang down to the knees or even to the ankles, and weigh many pounds. They prevent sexual connection, and cause discomfort by their bulk and weight, but they do not affect the general health. They do not become strictly pedun- culated, but when they are large the base, however, is somewhat nar- rower than the middle of the tumor. Exceptionally they may give rise to thrombosis and pyemia. Chyluria is a frequent accompani- ment of elephantiasis. Pathological Anatomy. — The swelling is chiefly situated in the skin and mucous membrane ; the lympliatics are dilated and the papillae enlarged. The underlying subcutaneous connective tissue and the epidermis are also increased in thickness. In the tissue compos- ing these tumors are found yellow elastic fibers and deposits of pig- ment. According to the different consistency of the tumors the tissue contains more or less serum. Diagnosis. — It differs from diffuse ^6roK/ by the history of a fever- ish beginning or repeated attacks of lymphangitis. The inguinal glands are often affected. Not only the connective tissue, but the skin itself, is thickened. AVhen tiie tumors are examined micro- scopically, we find dilated lymph-spaces and yellow elastic fibers. Prognosis. — The disease never disappears spontaneously, and is only curable in the beginning. Its progress extends over many years. It does not shorten life except in the rare cases of thrombosis and pyemia. Treatment. — During the acute stage antipyretics and cold applica- tions are used. Change of climate is desirable. In young subjects sulphide of calcium (gr. 1-1|, twice a day) is chiimed to have effected a cure in a month or two. Massage and electrolysis may, under similar circumstances, prove useful and may be combined with the sulphide of calcium. In cases of long standing, amputation is the only remedy. This may be performed in different ways : DISEASES OF THE VULVA. 299 a. Scbroeder's method is to cut from below upward, a small part at a time, and unite the edges by deep sutures before progressing with the operation. b. Munde introduced long pins through the base of the tumor, surrounded it with a temporary elastic ligature, cut the tumor oif, loosened the ligature, tied bleeding vessels, and united the edges. c. Silver-wire sutures may be drawn through the base before cut- ting, the vessels tied with catgut, and the sutures closed. d. The tumor may be removed with the galvano-caustic M-ire or the thermo-cautery. The cutting operations are preferable, since there is good hope of obtaining complete or partial union by first intention. 6. Fibroma. — A fibroid or fibroma is a tumor composed of fibrous connective tissue. It occurs in the vulva in two forms — the diffuse and the circumscribed. The etiology is obscure. The diffuse fibroma is much like elephantiasis in appearance, and the seat is the same; but while in elephantiasis the chief thickening takes place in the skin and the mucous membrane, the fibroma is formed by hyperplasia of the connective tissue, without growth of the skin and mucous membrane. The tumors are more or less irregu- lar, often divided into lobes or shooting-oif pedunculated portions. The skin covering them is 2)ink, whitish, or brownish. They have no intrinsic tendency to ulceration, but through friction superficial ulcers may form, and again heal up, leaving cicatrices. These tumors are not sensitive nor the seat of sj)ontaneous pain, except when they become inflamed. They grow slowly, but may become very large. They do not affect the constitution, but incommode the patient by their size and weight, and are a hindrance to coition, sometimes amounting to complete dyspareunia. Minute Anatomy. — The microscope shows connective-tissue fibers, with infiltration of round cells surrounding the vessels, but no change in the vessels themselves or the skin, and no yellow elastic fibres; which features distinguish fibroma from elephantiasis. Treatment. — Amputiition is the only remedy, and is carried out as stilted under Elephantiasis. The circmiiHcrihed fibroma is a rare affection. It is composed of the same tissue as the diffus(! form, but soon becomes pedunculated, and hangs down from the labiiun majus. The trecdment consists in cutting the pedicle near its base, tying with catgut the artery that nourishes it, and uniting the edges with sutures. 7. Myoma, Myxoma, Lipoma. — Tumors entirely similar to fibromas may Ik; formed of unstrij)ed nniscle-fibers (myoma); of a delicate fibrous reticulum, the meshes of wiiich contjiin a homogeneous basis- 300 DISEASES OF WOMEN. substimce and cells {myxoma) ; or of adipose tissue {lipoma). Quite eominonly the different kinds of tissue are intermingled with more or less fibrous tissue, forming mi/o-Jibromas, myxo-fibromas,^ etc. They are all benign, but the only treatment is amputation.'^ 8. Enchondroma of the Clitoris.^ — A single case has been reported of a pedunculated tumor, of the size of a fist, attached to the clit- oris, and composed of a cartilaginous ma&s, which in some places was softened, in others hard as a stone, probably through calcareous deposit. No microscopical examination seems to have been made. The treatment was, of course, removal of the tumor. 9. Horn of the clitoris is likewise a gynecological curiosity. A case is reported of a horny mass, in size and shape like the talon of a tiger, growing under the prepuce of the clitoris. Such a growth might wound the male during coition, and ought to be removed with the thermo- or galvauo-cautery. 10. Urethral Caruncle, Angioma, and Neuroma of the Vulva. — The names urethral caruncle, vascular tumor of the urethra, painful tumor of the urethra, and irritable vascidar excrescence of the urethra have been applied to a kind of growths found at or near the meatus urinarius, and characterized by their great vascularity. It is a quite common affection, and without causing any symptoms, is often seen accidentally in patients examined for other complaints. On the other hand, it may cause great pain, especially during micturition, and be so tender to the touch that sexual intercourse is rendered hateful or impossible. Even the friction of the clothes may suffice to start the * On account of the great rarity of these tumors, I may be pardoned for stating that on !Marcli 12, 1884, I removed one from a Swedish cook, jet. 34: it had been first noticed nine years l)efore. It hung from the middle of tlie left labium majus, to which it was attached by a pedicle of the length and thickness of a finger. The tumor itself was pear-shaped, measured 8 centimeters in length, 7 from side to side, and 4 in thickness. It had the color of normal skin, and was covered with peeling- off epidermis. At the lower end was seen an irregular slough of the size of a fifty- cent piece, surrounded by a suppurating line of demarkation which exhaled an oflTensive odor. In the pedicle was felt a pulsating artery of the size of the umbilical, and in it and near it on the labium majus were varicose veins. The tumor did not cause any p:iin, nor was it tender on pressure. I put a clamp on the base of the fedicle, formed two small flaps, tied the artery, and united the edges with catgut. t healed by first intention. When cut open a moderate amount of blood flowed from the tumor ; the surface Avas smooth, the skin not thickened, but so intimately connected with the tumor that it could not be dissected oflf". Microscoj)ical exam- ination proved it to be a myxo-fibroma. 1 have, in St. Mark's Hospital, seen a case almost entirely like the preceding one. ^ Geo. M. Tuttle of ]!sew York has removed a large fibroma molluscum from the labium majus. It measured 17j in. in circumference ; had a thick capsule, in cut- ting through which the appearance was strikingly like gut: thin, translucent, gas- eous in .feeding, and very resonant on percussion {Amer. Jour. Obslet., June, 1891, vol. xxiv. p. 715). ■* Tumors of the clitoris are extremely rare. Grace Peckham has described a cyst as large as a hen's egg, and collected twenty cases of diflferent kinds of tumors of this organ [Amer. Jour. ObMet., Oct., 1891, vol. xxiv. pp. 1153-1172). DISEASES OF THE VULVA. 301 pain. Sometimes there is only one such tumor, in other cases many. They are usually found just at the meatus, but may also develop more or le&s high up in the urethra. They are sessile or j)ediculated, of bright red color, usually sensitive, and apt to bleed after small injuries. They vary in size from a hemp-seed to a cherry. Even when thoroughly destroyed they arc apt to recur, or new ones may spring up in the neighborhood of the first. Microscopical examination has shown that these tumors are full of dilated capillaries and nerve-fibres, with hyperplasia of the papillae and connective tissue. Anatomically speaking, they are, therefore, angiomas and sometimes neuromas. The different composition ac- counts probably for the great difference in symptoms. Vascular tumors (angiomata) and nervous lumors (neuromata) form in rare cases small tumors on otlier parts of the vulva and the peri- neum. Diagnosis. — The bright red color, the great sensitiveness (when found), their insertion at the meatus, and their even, globular surface, make them easily distinguishable from ver/ctations. Treatment. — The only thing that affords help is the removal of the tumor. If there is a tliin ])edicle, it needs only to be twisted off M'ith a pressure-forceps. Small sessile tumors may be destroyed with chromic or nitric acid, neutralizing the superfluous acid by bathing the parts with a solution of bicarbonate of soda. Cocaine (10 per cent.) mav be used for local anesthesia. I^argcr sessile tumors are best removed with the thcrnio- or galvano-cautery under general anesthesia. In the interior of the urethra they must be exposed witii a uretliral speculum (p. 152), especially Jackson's, and cut or scraped off or destroyed with ctuistics. The latter should even be used on the base after cutting or scraj)ing, in order to prevent recurrence. 11. Ci/sti^. — Except those situated in the vulvo- vaginal glands, which will be considered later, cysts of the vulva are rather rare. They are single or multiple, and range in size from that of a pea to that of a fetal head. Tluy dilTcr nuieh in origin. Some are dcnaoid cyd-H, with the characteristic hairs, bones, and teeth in the interior. Others are atlieroiudu, ibrmed by occlusion of a sebaceous follicle, and contain a pultaceous mass. Most of them are filled with a serous fluid. Some seem to be due to an old extra vasati(jn of blood or to expansion of lyin])liatic vessels. Jf small, they do not give rise to anv symptoms, but if thev accpiire large proj)ortions, tiny may incommode the |)atient by i\\v\\' weight and size, and cause dyspareunia. If they become inflamed, they are j)ainful, and are accompanied i)y fever and other systemic (listnrl)an(;es. Tredliiicnt. — As th(y are intimately connected with tlie surrounding tissue, it may i)e diflicult to enucleate! tluiin. If so, a part of the wall 302 DISEASES OF WOMEN. is excised, the interior cauterized, packed witli iodoform gauze, and left to heal by granulation. 12. Cancer. — Compared with the uterus, the vulva is rarely the starting-point of cancer. Different kinds are found here — epithelioma, medullary carcinoma, atrophic carcinoma (or scirrhus), and sarcoma, with its variety melano-sarcoma, the cells of which contain brown pig- ment. They are all malignant, tending toward local destruction, undermining the constitution, and ending in death. Epithelioma (Fig. 220) is in so far less malignant than the other varieties of cancer as its course is slower. Fig 220 f.-^-=^)l(^^. Epithelioma of Vulva (P. Zweifel): a, clitoris; 6, fossa navicularis; c, vaginal entrance; rf, torn perineum ; t/g, cancerous nodules in the skin. Etiology. — Cancer appears mostly after the fortieth year, but has even been found in childhood. Psoriasis of the parts has a tendency to become cancerous. Otherwise tiie cause is unknown. ^Symptoms. — The most common starting-point is the sulcus between the labium majus and minus or the lower edge of the labium majus, more rarely the clitoris or the meatus urinarius. It begins as small nodules in the skin or mucous membrane, covered with an increased mass of epithelium, whicli often causes distressing itching. Later, DISEASES OF THE VULVA. 303 these nodules become excoriated, secrete a thin, malodorous fluid, form ulcerations that become confluent, and spread over the neigh- boring parts. Soon the inguinal glands become swollen. The ulcers are irregular, have discolored margins, an elevated floor, and are often covered with a new growth of cancerous tissue, which gives them the appearance of a raspberry. They have no tendency to enter the vagina. They are liable to bleed and cause pain. Sometimes the surroundings become hard as a board, and the vaginal and urethral ojienings may become obstructed. Prognosis. — The patients usually succumb at the end of two or three years. Diagnosis — Lupus heals in one place while destruction extends in another, is not so hard, causes slight pain, and is inodorous. The inguinal glands swell late or not at all. The general health remains good. Chanci'oid is not indurated, has sharply-cut, perpendicular edges, and the inguinal glands are imj^licated much sooner. Chancre presents a surface much like that of the excoriated cancer nodule, and has the indurated floor, but the history, the early appearance of adenitis, and the development of other syphilitic symptoms will soon clear up the diagnosis. Mucous patches, even if excoriated, do not form destructive ulcers, and disappear soon under local and general treatment. Treatment. — The nodules and ulcers ought to be eradicated at once. If po&sible, it sliould be done with knife and scissors, and the edges united by deep sutures, which allows of union by first intention ; otherwise the thermo- or gal va no-cautery is used. If the urethra is implicated, as much of it as feasible should be left, in order not to interfere with the retentive power. If the inguinal glands are affected, they nuist be enucleated, but even if they are removed en- tirely, the disease cannot be arrested permanently. 13. Lupus, Esthiomhie (Huguier); Chronic Liflamraation, Infiltra- tion, and Ulceration (R. W. Taylor). — The doubtful position of lupus of the vulva in the system of gynecological diseases necessitates an exception from the rule followed in this work not to enter into his- torical developments. In 184!), Huguier, a French piiysician, de- scrilKxl a disease of the vulvo-anal region under the name of esthio- mP.ne, which was claim<'d to be identical with lu])us as found especially on the face. The name '' lu|)us" has prevailed, and a certiiin number of cases have been reported in (Ufferent countries.' The pathologi/ of luj)us itself is not yet settled, and so much tlu; less can we de(Mdc whetiier the disease attacks the external female 'Grace rcckham, in an excellent paper fortified by microscopical examinations by II. ('. Co.! i Am»;: Jour. OhM., 1HS7, vol. xx. p. THo), lia,s collected 18 cases, of whicb slie eliminates some as tuhercnlar, carcinomatous, or not ulcerative, and retains 15.!, iiu-lusive of lier own. 304 DISEASES OF WOMEN. genitals or not. According to Koch's great authority, lupus is simply tuberculosis of the skin, and only that affection which is caused by the presence of his bacillus tuberculosis deserves the name ; but this microbe has so fur been looked for in vain in lupus vulvae. Others claim that an infiltration with small round cells, clustering together in nodules, esi)ecially around the capillary vessels of the skin, or a diffuse infiltration of the papillary layer or around the glands and hair-follicles of the skin, constitutes lupus. Still others lay particular stress on the presence of giant cells in the clusters of small round cells. Others, again, contend that all this is not characteristic of lupus, but may be found in any iuHammation with formation of granulation tissue and proliferation of the cells of the connective tissue.' R. W. Taylor^ denies altogether the existence of lupus in the female geni- tals. Based on his large experience in Charity Hos{)ital, he includes all the inflammations and infiltrations of the vulva of non-malignant origin in the following categories : 1. Small hyperplasije, caruncles, and papillary growths; 2. Large hyperplasia. 3. Hyperplasia resulting from acute and chronic chancroids ; 4. Indurating edema of syphilis ; 5. Hyperplasia resulting from chronic ulcers, so-called chancroids, in intermediary and old syphilis; 6. Hyperplasia in old syphilitics, presenting no specific character and occurring soon or long after the period of gummy infiltration, in some cases being coexistent with specific lesions elsewhere. The cases of formation of tumors, combined with ulceration, con- stituting the condition commonly called lupus vulvae, that have come under my own observation, were all developed on a foundation of recent or old syphilis. What has been called lupus vulvae (Fig. 221) consists in ulcera- tive lesions of the vulva characterized by their slow development, absence of pain, a purple color, thickening, induration, and forma- tion of detached tumors. Hyperplasia and destruction go hand in hand, but the hyperplastic process ])reponderates. The deformity extends often to the perineum and the anus. The inguinal glands may become swollen, but are oftener not affected. The general health stays good for years, and those who are not cured succumb usually to constriction of the intestine and peritonitis. Locally, great destruction takes place. Fistulous tracts may burrow into the labia and around the rectum, and fistulae may open into tlie urethra, the bladder, or the rectum. Fortunately, this destructive hyperplastic affection of tiie vulva is a rare disease. Etiology. — Those who do not look upon the ulcerative hyperplasia ^ Coe, I. c, Ira Van Gieson in R. W. Taylor's paper. 2 R. W. Taylor, iV. 1^ Med. Jour., Jan. '4, 1890. DISEASES OF THE VULVA. 305 of the vulva as a disease sui generis, attribute it to the large vascular and nervous supply of the genitals, to the injuMes they are frequently Fig. 221. Lupus of Vulva (Iliibcrlin). exposed to, to tiieir dependent position between the thighs, to lack of cleanliness and care, and the irritation cau.sed by uterine or vaginal disciharges. IHar/noHlH. — EjntheliohKi is usually more localized, of niucii greater density — even to stoniness — is pHxluctive of a large warty or papilla- niatous and ulcerated surface, and is very soon acconij^anied by enlargement of the inguinal lymphatic glands. The ulcerations of epithelioma are upon the surface, while those in so-called lupus are mostly foiuid in interstices, tissurcs, and at the b;use of tumors. Epi- thelioma gives ris<! to lancinating pain ; lupus is painless or causes only smarting or pruritus, esjK;cially after micturition. The discharge 20 306 DISEASES OF WOMEN. that emanates from the ulcei's in lupus has little or no odor. An ulcerated part may heal spontaneously or in consequence of treatment, but the cicatrice is liable to be affected by a new growth of lupus. The microscope settles the question with certainty by showing the epithelioma to contain cancer-uests of concentrically arranged cells of the epithelial type. Prof/nosis. — We have already stated that the disease is a very tedious one, extending over years. It does not in itself undermine the constitution, but may lead to intestinal obstruction and peritonitis or general exhaustion. In patients over forty any vulvar tumor, even a caruncle or a papilloma, may degenerate and become cancerous. If not checked, the disease may cause great destruction, and give rise to much annoyance by perforating the partitions between the different hollow pelvic viscera and the external genitals. Treatment. — On account of the dangers lurking in the background treatment ought to be quite active. The indication is to remove tumors and heal ulcers. Simon's sharp spoon, strong caustics — e. g. nitric acid, the thermo-cautery, the galvano-cautery, the galvano- caustic wire — may all be used to advantage, but, if possible, it is preferable to cut away all diseased tissue and unite the edges with sutures. Fistulous tracts may be laid open by means of the elastic ligature. It goes without saying that the utmost cleanliness should be practised by means of baths, fomentations, and injections. Oftcm a tonic treatment with iron, quinine, cod-liver oil, etc., or local or general antisyphilitic treatment, may be called for in combination with the local mechanical treatment. CHAPTER XIII. Tuberculosis. Tuberculosis of the vulva is an exceedingly rare affection ; which is strange, since one would think that occasions of direct inoculation, either from the same or another individual, by means of fingers, handkerchiefs, towels, or the sexual act, would present themselves frequently. But the fact is that the more we approach the surface of the body the rarer becomes tuberculosis in the genital system. It forms ulcers with sharp edges, sinuous contour, and a depressed grayish-yellow bottom covered with a cheesy detritus. Around the ulcers are often found small opaque, yellow nodules. In the dis- charge of the ulcers and in the tissue forming them and the nodules are found tubercle bacilli. In the mucous membrane are found clus- ters of polygonal cells surrounded by a zone of small round cells, and containing giant cells, in the interior of which may be found tubercle DISEASES OF THE VULVA. 307 bacilli. As a rule, similar affections will be found in other parts of the genitals and in the lungs. Treatment. — The general treatment is the same as for tuberculosis in other parts — nutritious diet, tonics, sunshine, fresh air, and, per- liaps, one of the modern hypodermic injections. The local treatment consists in application of tincture of iodine or iodoform. If this does not suffice to eradicate the disease, removal with the knife or destruction with caustics or cautery is indicated in the early stages. If the patient is far gone, mere palliative treatment with the curette and iodoform or aristol is all that should be attempted. CHAPTER XIV. Progressive Atrophy of the Nymphs (L. Tait), Kraurosis YuLV.Tc (Breiskyj. At or after the menopause, and quite exceptionally in younger years, is sometimes found a peculiar atrophy of the mucous membrane of the inner side of the labia minora. It begins as small red spots, depressed under the level of the surrounding mucous membrane, ten- der and prone to bleed, transitory or spreading. They may disappear in one place and reappear in another, or spread serplginously. J^ater, the mucous membrane contracts, so as to cause considerable coarcta- tion of the vestibule. The stenosis may be so great that hardly a finger can be introduced into the vagina. Coition becomes ])ainful, and childbirth is accompanied by tears of the tissues. When the dis- ea.se is fully developed, the labia minora seem to be absent. The raucous meml)rane appears dry, smooth, and cicatricial. Sometimes there is a slight yellow discharge. In many cases itching or burn- ing is complained of. The cause of the disease is unknown. Perhaps it is due to infec- tion from trachoma.' Its course is very slow. Patholofjical Anafotni/. — Microscopical examination of the red spots shows dilated ca])il!arics, with thinned walls, and ncrve-tibres. AH ov(!r the affected i)art of the mucous inenil)rane the rete niucosum is thin, so that in many phices tlu.' horny epidermis-cells lie directlv on the papiiUe. These are mostly siiort and of" luxven leiigtii ; the papillary layer is composed of straight fil)res lii<e a cicatrix, and the sebaceous and sudoriferous glands disa])j)ear. Treatment. — Kraurosis vuivie is a very intractable disease. ( 'ocaine is said to increasi; the sufferings. Aj)])lications of strong carbolic acid ' I)r. A. W. Johnstone, of Ciiicitiiiati, found that in every case whieli liad come under liis ol)scrvati<>n, some member of tlie patient's family \v:is alii'ctcd willi traclioma of the eyelid«, Mcil. Uncord, June .'5, 1S9'.». 308 DISEASES OF WOMEN. and a pledget steeped in a saturated solution of acetate of lead are rec- oniniended. Dr. Johnstone recommends yellow oxide of mercury ointment (gr. iv to vaseline .^j). A cure has been obtained by cutting away the affected part of the mucous membrane and uniting by sutures. It may also be destroyed with the thermo- or galvano-cautery. CHAPTER XV. Diseases of the Vulvo-vaginal Glands. The vulvo-vaginal glands may be the seat of catarrh, cystio degeneration and abscess. 1. Catarrh of the gland is rare. It is characterized by hypersecre- tion of mucus and redness of the mucous membrane surrounding the opening. The duct may become dilated, so that a uterine sound may be passed through it, or it may become closed, and then a retention cyst is formed. Sometimes the accumulated secretion may be thrown off in paroxysms, constituting a kind of nocturnal emission. The treatment is not satisfactory. The duct should be dilated with probes, and astringent antiseptic fluids injected. On account of the emissions, it has been recommended to extirpate the glands. 2. Cysts. — There may be a superficial or a deep cyst. The former is supposed to be formed by the duct. It forms a small round tumor immediately imder the mucous membrane, just outside the vaginal entrance. It may vary in size from that of a hazelnut to that of a hen's egg. The deep cyst is situated in the gland itself, and may be unilocular or multilocular. It forms a large tumor which is situated in the posterior part of the labium majus. Both form well-defined globular or oval, elastic tumors. The contents are ordinarily like the raw white of an egg, but may be chocolate-colored from admixed blood or purulent when inflammation has taken place. As a rule, the duct is closed, but by increased pressure it sometimes opens again. If not inflamed, these cysts are indolent, but they may cause some dis- comfort by their size and be an obstacle to sexual intercourse. The most common cause is gonorrheal infection. Diagnosis. — Hydrocele is situated more forward, below the external inguinal ring. The same applies to anterior labial hernia. Hernia of the ovary is harder, and pressure on it causes a peculiar sickening feeling. Posterior labial heryiia can be replaced through the vagina. Vulvar abscess has less distinct limits, is more tender, and the skin is red. Abscess of the gland is tender, hot, red, and accompanied by fever. Treatment. — Part of the contents may be drawn out with a hypo- dermic syringe, and replaced by an injection of chloride of zinc DISEASES OF THE VULVA. 309 (1 to 10). The contents may be withdrawn entirely, aixl an injection made with pure tincture of iodine or a 5 per cent, solution of car- bolic acid. The anterior wall may be cut off, the cavity washed out with a solution of bichloride of mercury, and packed with iodoform gauze, which has to be renewed every few days till the cavity is filled by granulations. Finally, the whole gland may be extirpated, and union by first intention attempted by means of sutures. Modus operandi: The patient is in dorsal position. By seizing the labium between thumb and index-finger, the operator makes the swelling protrude. Now he makes a longitudinal incision, about 1^ inches long, through the mucous membrane covering the cyst, and another in the same direction through the fascia. Xext, he seizes the gland with a tenaculnm-force])s and pulls cnit all the time while he sepa- rates the gland from its surroundings, partly with closed scissors or the nail, partly by dissection. Three or four small arteries may spurt and "are clamped. A large and deep hole is left with an oozing: surface. Under this whole surface is carried a runnintr suture of medium-sized catgut, which arrests hemorrhage and abridges the after-treatment very mucli. Exceptionally it may be advisable to use tier-sutures of catgut (p. 237). 3. Abscess. — With or without preliminary formation of a cyst the gland may suppurate and form an abscess. Tiic left gland is more frequently affected. The process is accompanied by the usual signs of inrtammation — pain, swelling, redness, heat, and considerable systemic disturbance. Tiie inguinal glands are commonly impli- cated. If left to Nature's sole eiforts, the abscess breaks on the inside of the labium majus in one or more places, and often fistulous tracks remain. Tiierc is in many women a tenih'ncy to repetition of such absc(!sses. Tiie pus lias the same offensive odor as abscesses in the ischio-rectal fossa or near the i'auces. Cronococci have been found in the pus-cells. The abscesses may l(!ave a c/ironlr suppuraiion of the gland, or such a condition may (h^velop without abscess. There is then little swell- ing and tenderness, but a continual discharge of a purulent fluid through the duct of the gland. This suj)puration is perhaps alwavs brought on by gonorrhea, and contimially gives rise to new infection. I)i(ir/no.^is. — Fiiriinr/ts are situated in the skin. P/def/iiioxoxs ru/rHi.s has not the dislliiet limits and the ])eeuliar situation of the abscess of the gland. A xfercoral (thsref^x originates nearer the amis. Trefduicnt. — The al)se((ss must be laid oi)en by a long incision on the inner side of the labium majus, disinfected, and packed witii iodolbnn gauz(.'. The oj)ening may conveniently be made with J*a(juelin's cau- tery. \i there is fre(|uent recurrence of the formation of such abscesses or a chronic suppuration, it is best to extirj)ate tlu; gland in ioto. It is not worth while trying primary union. It rarely succeeds, and it Ls 310 DISEASES OF WOMEN. better to pack the wound with iodoform gauze. The extirpation of the gland should be done at a time when the surrounding tissue is not inflamed. In using the knife, it should be remembered that the gland lies close up to the vulvo-vaginal bulb, only separated from it by a thin fjiscia. Wounding the bulb might give rise to hemorrhage. The incision should, therefore, always be made from the bulb backward. Instead of incision or extirpation, injection with a saturated solution of salicylic acid in alcohol has been praised in cases of recurrent Bartholinitis. If the contents are purulent, it may be necessary to repeat the injection.' CHAPTER XVI. Venereal Diseases. Venereal diseases form so great a part of the affections that come under the observation of the gynecologist, and are so often the cause of others treated by him, that a brief resume of the most com- mon features of these diseases seems desirable in a work of this kind. 1. Gonorrhea. — We have already spoken of the gonorrheal vulvitis (p. 286). It has so great a tendency to implicate the urethra that the presence or absence of urethritis has a certain diagnostic import- ance. It enters often the duct of the vulvo-vaginal gland, and may cause catarrh, cyst, abscess, or chronic inflammation of the gland. In most cases the inflammation spreads up the vagina to the vaginal portion of the uterus. Fortunately, it generally stops here, but some- times it invades the cavity of the uterus, causing purulent endome- tritis ; attacks the lining membrane of the tube, producing salpingitis and pyosalpinx ; and reaches finally the ovary and the peritoneal cavity, givnng rise to oophoritis and peritonitis — conditions tliat may make the patient an invalid for life or necessitate capital operations. It will, therefore, be seen that a gonorrhea in the female is a much more serious disease than the corresponding affection in tiie male. If limited to easily accessible parts, the disease may be cured in a few weeks ; but if it invades deeper parts, especially the vulvo-vaginal glands or the tubes, it may become chronic and persist indefinitely until the focus of infection is removed. In regard to treatment of the external genitals, sufficient has been said in speaking of vulvitis (p. 287) and the diseases of the vulvo- vaginal glands. As to that of the internal genitals, the reader is referred to later chapters, where the diseases of the vagina, uterus, tubes, and ovaries are discussed. 2. Chancroid. — Chancroid, or soft chancre, is frequently found on, ^ Cordier, LyoJi Medical, Dec. 19, 1S97. DISEASES OF THE VULVA. 311 the vulva and surrounding parts of the skin, while it is rare on the walls of the vagina, but appears more frequently on the vaginal por- tion of the uterus. Whether inoculation takes place at once in several places, or that from the first affected part the poison is carried to other points, as a matter of fact chancroids are commonly multiple in women. A chancroid is a contagious, inflammatory, destructive ulcer. On the mucous membrane it begins as a minute yellow spot surrounded by a red ring. Soon the epithelium over the spot is lifted so as to form a pustule, and is then carried off, leaving an ulcer. On the skin the ulcer may form without the intervention of a pustule. The ulcer is usually round or oval, but may become irregular by extension or the confluence of several single ulcers. The edges are cut perpendicularly, minutely jagged, and more or less undermined. The ulcer is sur- rounded by a red halo or areola. The floor is uneven and covered with a yellow film of debris. The secretion is in the beginning rather abundant, and has a peculiar, very jienetrating and nauseating odor. It is thinner than that of gonorrhea, and has a brownish color from admixed blood. Under the microscope are seen pus-corpuscles, led blood-corpuscles, and detritus, or broken-down tissue. If properly treated, chancroids heal in a few weeks. If neglected, they persist for many months, go on forming new ulcers indefinitely, and may cause great destruction, and even, in rare cases, become fatal. Complications are less common than in the male. It is even rare to see an inguinal gland become inflamed and form an abscess. Occasionally, however, in unhealthy and weak subjects phagedena may set in, and extend far over the nates and tiie abdominal wall. Peculiar to women is what is called the chronic chancroid. It begins as an acute chancroid, but loses its infecting power, and causes often hy[)erplasia of the surrounding j)arts. (See Lupus, p. 303.) It is entertained by lack of cleanliness, gonorrheal and leucorrheal discharges, and drink. The term is even used in speaking of "any good-sized intractable ulcer" of the vulva, although there is no ])roof that it began as a typical acute ciuuicroid.' For years women affected with such ulcers and hyperplastic formations may feel well, but in the course of time the ulcers may perf"orate the urethra, the bladder, and the rectum, or i)urro\v far away under the skin, forming lai'ge cavities, which may open by fistulous tracts about the buttocks or the thighs. Hemorrhages of greater or less severity may take place, or erysi|M'las start from tin; genitals. In the course of years such women mjiy fall a pr(;y to pulmonary |)hthisis or succumb to kidiuy and liver complaints. Some; an; subject to chronic diarrhea and dys- entery, or are finally c:irri<'d off by jwemic infection. Treatment. — The acute chancroid should he. destroyed with nudi- ' K. W. Taylor, S. Y. Med. Jmr., .Jan. 4, iS'.tO. 312 DISEASES OF WOMEN. luted carbolic acid, nitric acid, or Paquelin's thermo-cautery, under local anesthesia with cocaine. The affected parts must be kept from contact with others by covering them with pieces of absorbent lint or pledgets of absorbent cotton dipped in some mild solution — e. g., ^i. Acidi carbolici, TTLxx to xl ; Glycerini, Sss ; Aquse, q. s, ad siv, or smeared with the iodoform-balsam-of-Peru ointment (p. 284). A^aginal injection with bicarbonate of soda or borax, followed by cor- rosive sublimate (1 : 5000), should be used several times daily. The substance tiiat makes tlie ulcei-s granulate fastest after cauterization is iodoform, which is powdered on them daily. As a colorless and odorless substance, salicylic acid mixed with 4 or 8 parts of subnitrate of bismuth is often preferred, and may answer a good purpose. When granulation is started, it may be hastened by dressing with sol. argeuti nitrat, (gr. j-5iv), liq. sodii chlorinat. (sij-.siv), sol. acidi borici satur., or vinum aromat. diluted with 4 parts of water. If a chancroid becomes phagedenic, the constitution of the patient must be improved with nourishing diet, stimulants, and tonics. Tlie unhealthy tissue may be removed with the curette, or by touching it with nitric acid, bromine-glycerin (1 : 3), or Paquelin's cautery. After that the patient should use hot sitz-baths (98°-102° F.) from eigiit to twelve hours daily. Bubos are painted with tincture of iodine. If they suppurate, they must be o])ened in their full length, washed out with disinfectants, packed with iodoform gauze, covered with a compress of the same material, and over that a peat-bag or a layer of moss impregnated with corrosive sublimate or a thick layer of plain cotton-wool. Pressure by means of a sj^ica promotes recovery in a marked degree. This dressing is changed daily. The curette may be used to remove broken-down glandular tissue. When the cavity granulates, the iodoform ointment or the pure bal- sam of Peru is used for dressing. An occasional painting with nitrate-of-silver solution (gr. x or xx to .Ij) hastens the process of healing. Pure boracic acid is also excellent for dressing. In more chronic cases the glands may be removed by enucleation. 3. Syphilis. — The initial lesion of syphilis, the hard chancre, is often not to be found on the genitals of women. The cause of this is twofold : First, the lesion by which inoculation of the syphilitic virus takes place is much more frequently than in man situated on other parts of the body, especially the breast and the lips. This is so in 25 per cent, of all cases. Secondly, the characteristic induration of the true infecting chancre is often missing. Tiie syphilitic neo- DISEASES OF THE VULVA. 313 plasm is there, but the new-formed cells are so few in number or so loosely patched together that the characteristic sclerosis is not devel- oped. When, furtliermore, we take into consideration that the female genitals, on account of their shape, are much less open to inspection, even to the patient herself, and that the initial lesion may heal with- out leaving any visible cicatrix, it will be undei'stood that sometimes it is entirely overlooked, and that secondary and tertiary symptoms may appear althougii there is no history of any sores on the genitals or elsewhere, and no evidence can be found of their previous existence. The first period of incuhaiion — that is, the time elapsing between the infection and the ap})earance of the hard chancre — varies in length from ten to seventy days. The second period of incubation — that is to say, the time from the appearance of the chancre to that of general or constitutional symptoms of sy})hilis — occui)ies from forty to seventy days. The first and second periods of incubation together commonly last from sixty to ninety days. During the second period of incubation the primary lesion acquires greater development and the inguinal glands become swollen. This happens from live to ten days after tiie appearance of the chancre. The syphilitic poison may come from a hard chancre, from sec- ondary syphilitic manifestations, especially mucous patches, or be inoculated with blood or lymph. Any part of the vulva and its surroundings may be the seat of the initial lesion. Most commonly it is found on the labia major, some- times (m tiie cervix uteri, and very rarely on the walls of the vagina. It begins as a superficial, Hat, reddish erosion, which soon forms a round or oval flat ulcer of dark-rc<l or grayish color, with smooth floor, sparse serous secretion, and sometimes a more or less hard base. Often an infection with pyogenic microbes takes place simultaneously witii the introduction of the syphilitic virus. Then the secretion of tiie ulcer becomes more ])urul('nt and the floor shows local gangrene. Exceptionally, a syphilitic lesion may become phagedenic. If a doul)l(! infection with sy|)liilitic virus and that from a chancroid takes place sinuiltaneously, the chan<;roi(l is first developed, and changes its a])jK'arance in the course of time, so as to form a syphil- itic chancre {mixed chancre). The primary lesion is commonly single, but may be multi])le an<l may be combined with soi't chancres. It stays a variaide length ol time — even several months — but, as a rule, heals readily, and may dis- appear without leaving any trace. The inguinal glands form a duster of indolent swellings. IJut where there is a suppurating ulcer, there may also occur inflammation and abscess of the inguinal glands. Didf/noHi.s. — Since the characteristic induration is often absent, the diagnosis of the ])rimary lesion becomes more diflicult in women than 314 DISEASES OF WOMEN. in men. The following points ' may occasionally be found useful in making a differential diagnosis : In herpes pr'ogeiiitalis the inguinal glands are not aifected ; the base is soft ; the contour is poly cyclic — that is to say, composed of regular segments of small circles that have been blended together ; the development is more limited, and the exco- riation heals rapidly ; the affection itches ; and, as a rule, the erosions are multiple. Chancroid is nearly always multiple. It forms a deep ulcer of yellowish red color, with perpendicular, undermined edges, uneven, worm-eaten floor, soft base, and abundant purulent secretion ; the pus, when inoculated on the patient, forms another chancroid ; the inguinal glands are not swollen or form an inflamma- tory bubo which may produce an abscess with simple or chancroidal pus. Treatment. — The primary lesion being a symptom of an infection that already has taken place, cauterization is useless, and objectionable on account of the inflammation it brings about in the circumference. The genitals should be kept clean and the ulcer dressed with absorb- ent lint or cotton soaked in bichloride-of-mercury solution (1 : 1000 or 2000) or one of the other solutions mentioned above in speaking of chancroid, the dressing to be changed every two hours. If the ulcer suppurates or is the seat of molecular disintegration, it should be dusted with iodoform or equal parts of calomel and bismuth, or dressed with the lotio hydrargyri flava containing corrosive sublimate, or lotio hydrargyri nigra, made with calomel. In cases of consider- able induration blue ointment may be rubbed on the seat of the swell- ing and applied to it spread on lint. If the sore is covered with a pultaceous mass, cauterization with carbolic acid, nitric acid, or chloride of zinc, dissolved in equal parts of distilled water is indicated. In regard to phagedena the treatment is the same as described under Chancroid, combined with general antisyphilitic treatment. Secondary Si/philis. — The vulva is the seat of predilection of mucous patches in women. In the vagina they are exceedingly rare, but appear more frequently on the cervical portion of the uterus. They are often found symmetrically on both sides of the vulva, not on account of auto-inoculation, but because the irritation is the same. They form round or oval spots, with a tendency to coalesce. They are a little elevated above the mucous membrane, and have well-defined steep borders. The color is rosy or grayish red. They have a some- what granular surface, and secrete a malodorous serous fluid. They are quite amenable to treatment, but may, if neglected, form large cauliflower-sliaped tumors like vegetations, and may, like them, be- come gangrenous. On the vaginal portion mucous patches appear as ' A. Fournier, Lemons sur la Syphilis etudiee particidiiremeni chez la Femme, Paris, 1873, pp. 261, 281. DISEASES OF THE VULVA. 315 small red erosions, or, more rarely, as superficial ulcers. Combined with general mercurial treatment, mild cauterization with nitrate of silver makes mucous patches soon shrivel and disappear, without leaving any cicatrix. Tertiary Syphilis. — Ginumous nodes are not rare in the labia majora. They form first deep-seated globular tumors, which may break and leave ulcei-s. These latter may be difficult to diagnosticate from other ulcers in the same locality, but are distinguished from them by being rapidly healed by the internal use of potassium iodide. At the same time, the usual precautions in regard to cleanliness and protection that have been detailed above should be observed. CHAPTER XVII. Prolapse of the Urethra. To describe all the diseases of tiie uretlira and the bladder would require more space than we can aiford, and they do not strictly be- long to those organs the diseases of Avhich form the subject of this treatise. It might, however, be advisable to say a few words about prolapse of the urethra, on account of the diagnosis and the treat- ment. While a slight eversion of the mucous membrane of the urethra is exceedingly common, especially in women who have borne children, the extrusion of a sufficiently large part of it to form a tumor is of rare occurrence. It is mostly found in children, old people, or weak subjects. It is caused by straining during micturition or defecation — e. g. when a stone is lodged in the bladder or the anus is the seat of a fissure. The disease may implicate the whole circumference of the urethra or only a part of it, most commonly the lower. In the first case the urethral canal is found in the centre of the tumor; in the second, it is placed excentrically. The prolapse gives rise; to or increases vesical tenesmus and may produce cystitis. In the beginning the tumor has the appearance of tiie normal mucous membrane, but later it becomes darker and denser, and is sometimes excoriated. J)i(i(/vos/s. — When the prolapse is total, the presence of the lumen of the canal in its center settles at once the diagnosis, li' it is j)artial, it may be taken for a ccni.nc/c, \mt it diflcrs from ihv. latter by always having a broad base and by being easily reduced, Trcdtinrnt. — Simple reduction with a finger or sound, followed by the use of a cup|)ed bougie, with tannin or the application of tincture 31G DISEASES OF WOMEN. of iodine, rest in bed, and hot vaginal douches and affusions, may be tried. If they do not succeed — which can only be expected in slight ciises — operative interference is called for: 1. The tumor may be transfixed at its base, tied in two halves, and cut off. 2. The deeper part of the mucous membrane may be secured by inserting a suture on either side, and uniting the two edges of the wound with a continu- ous catgut suture after cutting the redundant tissue off. 3. Emmet's buttonhole-operation may be performed by placing the patient in Sims's position, introducing his speculum, making a longitudinal incision on the vaginal wall corresponding to the course of the urethra down to the mucous membrane of the latter, pulling this through the opening made, introducing some transverse sutures through the vaginal and urethral mucous membrane, cutting off the redundant tissue over the sutures, and closing the latter. The prolapsed portion may also be cut off in front of the meatus with galvano- or thermo-cautery, but then steel bougies should be introduced during and after the healing in order to avoid stenosis. The cutting operations with sutures are the best. CHAPTER XVIII. Masturbation. Masturbation consists in the production of venereal orgasm by means of the hand, the tongue, or any kind of foreign body on one's self or another person. It is also called onanism, but not correctly, for a closer scrutiny of the ninth verse of the thirty-eighth chapter of Genesis will show that Onan had sexual intercourse with Tamar, but deprived her of his semen by spilling it outside of her body (an act called withdrawal). It is not usual to treat of this subject in works on gynecology, but since the thing exists, since it appears in innocent childhood, since it produces certain symj)toms, since it may be the cause of the most serious diseases, since the })hysician called as expert in a suit for rape may be able to exonerate an innocent man by knowing the effects of masturbation, — it is, in my opinion, proj)er to give some information about it here. Ma.sturbation may be indulged in by infants of either sex who have no idea what they are doing.^ They may either be taught the vice by unscrupulous nurses in order to make them quiet, or they may accidentally find out that certain movements produce a pleasur- ' A. .Taoobi, " On Masturbation and Hysteria in Young Children," Amer. Jour. Obst., vol. viii. No. 4, 1875, and vol. ix. No. 2, 187G. DISEASES OF THE VULVA. 317 able sensation. In older female children I do not believe the vice is so common as among boys, but later in life it is probably much more so in women than in men. This cannot be explained merely by the greater facilities offered the male sex for normal satisfaction of the sexual instinct without running the risk of having oifspring. There are several reasons for it, one of which is the less degree of orgasm felt by women daring normal sexual intercourse (p. 123). This, at least, would seem to explain the fact that many married women are given to this vice — a thing that is exceedingly rare in the male sex. The most common form of masturbation in women consists in titillation of the clitoris, be this executed by the person's own hand or tliat of another, or In- the tongue of another human being or of a dog, or by any other object. Less frequently the finger or other more or less penis-shaped bodies, such as roots or needle-cases, are intro- duced into the vagina. 1. Masturbation i)i Infanci/. — Masturbation in early childhood being in many respects ])eculiar, we must c-onsider its symptoms and treatment separately. In some cases there may be local changes, such as redness of the entrance of the vagina, moisture of the labia and vagina from over-secretion of the glands of Bartholin and the smaller muciparous glands of the vulva. But these cases are by no means frequent. Of much greater importance are certain other changes observable in the child, such iis the occurrence of sudden redness in the face, followed by paleness, twitching of the muscles about the eyes, hurried breathing, and a deep sigh. These spells come on when the child is sitting on the floor, often rocking to and fro or pressing the fists into the iliac fossa? or against the genitals. These attacks lead to anemia, bloatedness, and irritability of temper. Treatment. — First of all, infants and their nurses should be care- fully watched. If there are pin-worms in tiie rectum, they should be removed (p. 292). If the c()mj)osition of the urine is abnormal, it should be remedied l)y j)ro])er medicine, especially alkalies and ano- dynes. The couch should l)e hard, the cover not warmer than what is necessary to j)rotect the child. It should not have too rich food: large quantities of meat, eggs, spices, salt, and beer are injurious. Drugs that irritate the lu'opoietic system, such as cantharides or nitrate or chlorate of potash, sh<»uld be avoided or handled with care. During the act the child should be taken up, her thighs sej)arated, her hands removed from her alxlomen, and her mind diverted. J'he anemia and nervousness should be treated with strychnine, iron, and arsenic. When every other remedy has failed, clitoridectoiiii/ may still effect a cure.' ' At the request of I)r. Louis Fischer, I i)erforme<l (lie operation on a tliree- months' old child, who masturbated nearly ail the day. All known inedieal reme- dies and mechanical contrivances having; been nsed in vain by this distin^riiisiied pediatric, 1 anesthetized the child, seized the clitoris with a pair of forceps, and 318 DISEASES OF WOMEN. 2. Masturbation in Older Children and Adnltn'i. — Sipnptoms. — The froquontlv repeated act of self-abuse or masturbation with another })erson leaves certain local changes in the genitals which it is useful to know. It is true that not one of them is pathognomonic, but the presence of several of them must, to say the least, awaken suspicion and may help to determine the truth. The clitoris is both thickened and elongated. The glans is red and protrudes beyond the pre- puce. Tiie prepuce is lax, red, and thickened. The labia minora are elongated, flaccid, wrinkled, of brown, gray, or slate-like color, with black irregular spots due to the deposit of pigment in the deep layer of the epidermis. This change in size and aspect is often unilateral. On the inner surface of the labia minora is found a series of minute white or yellow spots like insect eggs, formed by hypertrophied glands. Sometimes the labia majora are likewise enlarged, flaccid, and wrinkled. The hymen may be torn, but is more commonly not so, but so lax that the finger enters without meeting any resistance. The vaginal entrance and the rima pudendi may be gaping. Often leucorrhea and other signs of vulvitis (p. 285) are present. The vulvo-vaginal glands may be inflamed. The vulva may show fresh scratches or old cicatrices, and the clitoris has been found Mounded and nearly bitten off — conditions which may cause hemorrhage or leave wounds slow to heal. As to the general health, women seem to have a greater power of resistance in regard to the effects of masturbation than men. There are, indeed, women who are confirmed masturbators, and yet enjoy excellent health, but, as a rule, they pay as well as the other sex for their illicit pleasure by pain, ache, and ailment. The works of specialists in this line must, however, be read with more criticism than their authors usually show in writing them, nearly every known disease, inclusive of pneumpuia, that ever has been observed in a woman addicted to masturbation having been put on the list of the consequences of the habit. Certain diseases are, nevertheless, found so often in masturbators, and the connection between them and the vice is so easy to understand, that we do not hesitate in looking upon them as cause and effect. We find inflammation of any part of the genitals, periuterine hematocele, and pelvic peritonitis — conditions which all stand in a natural relation to the irritation and frequent congestion of the genitals and pelvic organs. The nervous system sulFers more than any other, and in all its functions : the hands are apt to tremble or the gait may become unsteady ; the perception of all the senses loses more or less of its acuteness ; the memory weakens ; interest in all intellectual matters diminishes ; wandering pains of neuralgic origin are quite common ; removed glans and body with the thermocautery. The after-treatment consisted in the application of a weak solution of carbolic acid, and the child was entirely and permanently cured of its bad habit. Archives of Pediatrics, May, 1899. DISEASES OF THE VULVA. 319 hysteria, epilepsy, chorea, paralysis, and insanity may be developed, but it may be hard to decide whether the masturbation was the cause of the insanity or if the lurking insanity impelled to masturbation. I have seen a peculiar nemesis in a young lady who was accustomed to discount the pleasures of married life, and who, when she married a strong young man, failed to feel the slightest satisfaction in the normal relation between man and wife. Nutrition suffers, as a rule, soon. The patient loses flesh, the face becomes pale, dark rings appear under the eyes, the appetite is poor, the digestion difficult, and the bowels constipated. It is said that fresh cicatrices are liable to break up and ulcerate. The neighboring organs are apt to suffer. Sometimes the sphincter muscles of the urethra become paralyzed. Cystitis may be caused by the irritation, and the inflammation may spread up to the kidneys. Stone may form around foreign bodies used for masturbation which are lost hold of and enter the bladder — e. g., a hair-pin — or the for- eign bodies themselves may cause pain and endanger the bladder. The sphincter of the anus may become relaxed and give rise to pro- lapse of the rectum. Masturbation entails often sterility or abortion, and if children are carried to term they are apt to be puny, neurotic, and weak. Treatment. — The treatment must be moral as well as physical. The physician must use every effort to impress upon the mind of the patient the bad consequences of her vice. Any palpal)le cause of irritation, such as j)in-worms, accumulated smegma, adhe- sion of the prepuce to the glans of the clitoris, bladder catarrh, calculi, or hemorrhoids, nuist be removed. The focxl should be bland ; alcoholic beverages and spicy dishes should be forbidden. The body should be tired with manual work, gynmastics, or walking; the mind occupied by attractive subjects. Cold baths should be used in the morning, but not in the evening on account of the following reaction. 'J'he patient should lie on a hard matti'ess, lightly covered, with the arms al)ove the cover, and in a cool room. The nervous system must be (piieted with camphor, lupulin, the bromides of anunonium, pot;issium, and Sixlium, or monobromide of camphor. In the worst cases clitoridectomy is indicated, and has eflected some remarkable cures. It is a simple o])eration, but, as it has led to sej)- tic peritonitis and death, it ought to be performed with antise])tic precautions. It is only the glans and body that are removed. This may be done with a bistoury or curved scissors and sutures ap})lied, or one may use the therino- or galvano-cautery. Tiiere is no reason why this little bit of flesh should not i)e removed, and, as it certainly is the Tuost excitiiblc! j)art of the genitals, it is rational to do so in cases of abnormal excitability irresistibly leading to masturbation, ruining the health of the patient, depriving her of her mental faculties, or driving her to suicide. PART II. DISEASES OF THE PERINEUM. CHAPTER I. Injuries. Here we have to deal with only tlie anal part of the perineal re- gion, the injuries to the vulva having been considered above (p. 283). For convenience' sake we will, however, simply call it the perineum. The perineum is exposed to injuries from without and from within. I. Injuries from Without. — Contusions and contused, punctured, incised, or torn wounds, involving a more or less complete laceration of the partition between the genitals and the rectum, are produced by falling down on the upright of a chair, a slat of a fence, a pitch- fork, or similar pointed object, or by sliding down the balusters of a staircase against the boss of the newel-post. Similar lesions are some- times caused by the horns of cattle or result from rape where there is a marked disproportion in the size of the organs that come in contact. Treatment. — The treatment is the same as for injuries of the vulva. II. Injuries from WitJiin. — These are especially caused by childbirth. Lacerations of the perineum may be recent or old, complete or incomplete, open or submucous. A. Recent Lacerations of the Perineum. — The recent laceration of the perineum is a condition that is considered at length in treatises on obstetrics.^ Here we will only briefly allude to a few points which are necessary in order to understand the old lacerations, or which have special surgical importance. As we have seen in the description of the anatomy of these parts (p. 43), the parturient canal is, near and at its end, limited by two comparatively narrow openings, the vaginal entrance and the rima pudeudi, the first of which is circular from the beginning, while the second becomes so when distended by the child being pushed through ^ More detailed information on the subject may be found in my papers on " The Obstetric Treatment of the Perineum," Amer. Jour. Obstet., April, 1880, vol. xiii. p. 231, et seq.; and on "So-called Lacerations of the Perineum," Med. News, April, 1891, vol. Iviii. p. 454, et seq. 320 DISEASES OF THE PERINEUM. 321 it. Of these rings the inner one is again the narrower. They are the seats where laceration commonly begins during childbirth, and from which it may extend more or less into the neighboring tissues. The inner ring, the vaginal entrance, being the narrower of the two, suffers more constantly. But a su})erficial tear here, even if it extend far up into the vagina, is of little importance. A deep tear of this ring, involving the levator ani muscle with its two fascife (pj). 96, 97), is, on the contrary, a fruitful source of future suffering. The tear in the levator ani muscle is usually found backward and outward in the direction of the tuberosity of the ischium, probably because the mus- cle gets caught between this point and the head, while in the median line the rectum furnishes a soft i)ad between the vagina and the leva- tor ani muscle. The tear is much more common on the right than on the left side, which is probably due to the preponderance of the left occipito-anterior position, the occiput escaping from tiie genital canal, while the forehead is pressed against the posterior wall of the vagina. The external ring, formed by the expanded vulva, often escapes all injury through ciuldbirth, so that even the thin edge of the four- chette may ])e found entire in women who have borne children. It may, however, suffer in different places. The most conmion is a tear in the median line, beginning at the j)osterior commissure, from which it may extend down to and into the anus and up to and through the vaginal entrance. More rarely this perineal ru})ture begins in the center of the ])erineiun, and extends forward into the vulva, forming a similar tear as if it had started from the fourchette; and in the rarest of all cases the tear in the perineum becomes suiliclently large to admit of the ])nssage of the child through it without impli- cating the rima pudendi or the anus {ccniral laceration). If the perineum escapes or suffers little, the injiny often takes the shape of superficial tears on the labia majora or deeper tears in the lal)ia minora and vestibule near tiie clitoris (p. 283). Nearly all tears i)eing due U^ circnlMr ex[>ansion, the })arts separate laterally, and the rents have a longitudinal dii-ection more or less parallel to the axis of the parturient canal ; but if the severed halves of the perineum do not unite l)y first intention, they heul separately, each forming one-half of a cicatrice, in which way cicatrices with a transverse direction ar(! formed. This has given rise to the erroneous conception that the fn.-h tear also had lieen transverse, which it hardly (!ver is. Sometimes nature can elfect comj)let(,' agglutination and coalescence by first intention of any tear. I have myseli' seen this in inconij)lete laceration where the whole j)erineal body was s( vered to the rectum, and I have heard of the same lucky result in cases of coM)|)lefe lace- ration, in which nothing was done except to ti<! the patient's knees together, J5ut such a pnK-ess is (»i" so extreiiielv I'are occui reiice that 21 322 DISEASES OF WOMEN. it is fbolhardineas to wait for it. In the great majority of cases the natural healing is altogether insufficient. An incomplete tear in the median line will heal together a little by granulation at the bottom of the angle; the remainder will only heal over and form a con- tracted transverse scar. A complete tear will leave the anal ring broken : the sphincter retracts, its ends being plainly marked by a little pit of the size of a large pea on either side ; where the perineal body should be is seen a V-shaped cleft ; the mucous membrane of the rectum rolls out, forming a little red, soft, puckered cushion at the posterior circumference of the anal opening ; and the patient has no control over flatus and feces, which escape involuntarily and make the poor woman an object of disgust to herself and others. A tear involving the levator ani and the sinewy structures at the vaginal entrance weakens the support of the jielvic structures above. As soon as she gets up the patient complains of a disagreeable feeling of looseness and bearing-down. In course of time the vaginal mucous membrane bulges out in front and behind, the bladder sinks down, the uterus is first retroverted, then retroflexed, then it descends, and may finally hang between the legs. The strain on the utero- sacral and broad ligaments causes pain and backache. The vagina is inverted, and becomes unfit for one of its purposes. Exposed to friction against the clothes, the vaginal portion of the uterus becomes the seat of a deep ulceration. Treatment. — Fresh tears should be united immediately after the termination of childbirth (^primary perineorrhaphy). Rupture of the Outer Ring. — If the tear begins at the posterior commissure and extends more or less far toward the Fig. 222. anus without implicating it {incomplete laceration), and is not much over half an inch high (up toward the vagina), this may in most cases be done more easily and speedily, and with much less pain, by means of serrejines (Fig. 222) — fine self-holding clamps working on the principle of clothes-pins. These little in.stru- ments are applied, from one to three in number, by placing the patient on her left side, lifting the torn perineum between the thumb and index-finger, and em- bracino; it with the legs of the serrefine. The first is j)laced half an inch from the end of the tear, the fol- lowing with half an incii interval, and the last at the anterior end of the tear. Good serrefincs should have so little spring-force that the obstetrician can put them on the web between his own thumb and index-finger without feeling pain, and the legs nni.st be half an inch long beyond the cro.ssing.^ ' Serrefines were invented \>y the French surgeon Vidiil. Most of those on tlie market are of very inferior make, but Geo. Tiemann & Co. keep some good ones under my name. DISEASES OF THE PERINEUM. 323 In fat women tlio perineum cannot be folded as described, and therefore the serrefines cannot be used, and recourse must be had to sutures. Serrefines are inferior to sutures, but they have the g:rcat advan- tage that they may be used wlien the "operation" of stitcliing the torn perineum wouhl be declined or would do harm to the obstetri- cian's reputation. They may be put on without speaking of it, while the patient is lying on her left side in order to be cleaned. They are, therefore, of particular value to the young practitioner who has not such a command over his patient that she takes his word for good when he tells her that it is quite natural her peri- neum should be torn on account of the disproportion between the opening and the child that passes through it, and who nevertheless will blame him when the consequences of her tear make themselves felt. Sutures should always be used where the vaginal entrance is torn. If the tear extends up into the vagina, separate vaginal sutures should be passed, beginning at the upper end and going down as far as the perineal body. It may be done Avitli catgut, by interrupted or con- tinuous suture. For the perineal body silkworm gut is the best mate- rial. As a rule, three sutures are needed on the perineum proper. The patient is placed across the bed, with the buttocks drawn to the edge; the knees are bent and held by assistants, the feet are placed each on a chair; and the operator sits on a third between the two or kneels. The parts are irrigated with a disinfectant fluid, pref- erably creolin ; a large cotton tamj)on with an attached thread is pushed up into the vagina above the tear, in order to keep blood away from the field of o])eration. Siireds that hang loose by a pedicle are cut off. The left index-finger is introduced into the rectum, while the a&sistants stretch the torn parts symmetrically from side to side. A rather long curved needle is inserted on the left side, a quarter to half an inch outside of the edge of the tear and at the same distance from the j)()st(ri()r end of tli(! tear, and carried under the torn surface over to the corresponding i)oiiit on the otiier side. The sec- ond suture is placed about halt an ineh farther forward, j)arallel to the first, and is likewise entirely imbedded. It embraces often the lower end of tin; nuicous niembranc; above the tear. The third and last is ])laced a little Ixlow the posterior commissure. It goes only under the tear in the left labium majus ; the needle emerges on the line of demarkation Ix-tweeu this torn surface and the nuiet)ns niem- l)rane, is again entered on the eorresi>ouding point on the light lal)ium, and is |)uslie(l out on the eoi-respoiiding point ol" the skin. 'I'hese three sutui-es eorresixtud to sutures 2, 4, and G in Fig. 'I'-Uk I'Lxeetited with j)roper antiseptic ])recautions, this operation is nearly alwavs suecessf'ul. 324 DISEASES OF WOMEN. Before closing the sutures, the tampon is pulled out and the parts are again irrigated. My perineal pad, or antiseptic occlusion dress- ing, is applied. This consists of (1) a piece of absorbent lint, 12 by 8 inches, folded twice lengthwise, so as to become 3 inches wide, the average distance from one gen i to-femoral sulcus to the other; or a pledget of absorbent cotton of somewhat larger dimensions, in order to allow for shrinkage ; (2) a piece of gutta-percha tissue, 9 by 4 inches ; (3) a large pad of cotton batting ; and (4) a piece of unbleached muslin ^ yard square. The lint or absorbent cotton is wi'ung out of some antiseptic fluid and carefully applied over the vulva and the anus. The gutta-])erciia is washed with the same solution and ])laced over the first layer, turning the edges forward against the thighs. The outer layer of cotton batting serves only to give bulk, and is pressed up against the genitals by the muslin, which is fokled like a cravat 5 inches wide, and fastened to an abdominal bandage, so-called binder, in front and behind. This dressing is changed three or four times in twenty-four hours, or oftcner if the patient has a movement from the bowels or passes her urine in the meantime. Before a fresh dressing is put on, the parts are irrigated externally with antiseptic fluid, the patient lying on a bed-pan. No vaginal injection is given ; indeed, the genitals are not touched.^ The knees are bound loosely togetlier, so as to prevent wide separation, but permit limited motion. This is obtained by surrounding the knees with a wide ring of muslin, or two rings with a connecting piece like eye-glasses, which are prevented from sliding down by fastening them on either side to the abdominal binder by means of a long narrow strip of muslin called a suspender. The patient is allowed to urinate herself if she can, and the bowels are kept oj)en by means of a mild aperient. If the tear extends into the anus and more or less far up the rec- tum (complete laceration), the immediate operation is particularly indicated. Even if only partial success should be obtained, and a recto-vaginal fistula should remain, the general shape of the parts is retained and a subsequent operation much facilitated. Under these circumstances it is best to make a triangular suture, one row along the rectum, one along the vagina and vulva, and the third along the cutaneous surface of the perineum. The first two should be deeper, the last more superficial, by doing which the formation of a recto-vaginal fistula above the perineal body is best obviated. For the first two rows catgut or fine silk is used ; for the last silkworm gut or silver wire is preferable. Sjiecial care should be taken to unite the ends of the sphincter ani nuiscle on the principle that will be described below in speaking of Emmet's operation for the old rent. ' More details and an illustration are found in Garri.Lrues' Antiseptic Midnifery, p. 27, and Amcr. Syd. of Obst., ii. p. 351. DISEASES OF THE PERINEUM. 325 It" the parts are very edematous, the edges of the wound will gape when the swelling subsides. In such cases it is advisable to wait twenty-four hours or longer before operating, or, instead of tying the suture, half a dozen perforated shot may be passed over the free ends, and the last compressed so as to hold the suture in place. When, then, the wound later is foiuid to gape, the last shot is seized with a pair of forceps and pulled upon, carrying the suture with it, until the edges are again in contact, when the next shot is compressed and the first cut oif.^ With this method it is better to use silver wire, the ends of which may be turned out, so as to give a firmer hold on the shot. Rupture of the Inner Ring. — Since the rupture of the ring forming the vaginal entrance has much more serious consequences than that Recent Tears inside the Vagina and Suturing (H. Kelly): A, vaginal sutures passed; B, sutures tied on left side; C, sutures tied on both sides and cutaneous crown-suture in place ; D, all sutures tied. of the outer ring, except when the latter implicates the S])hincter muscles of the rectum, medical science ctdls for its immediate treat- ment; but in most cases me(lit"al diplomacy and other considerations will throw their weight into tlie other scale. These tears are mostly ])roduced by an unskilful conduct of labor, such as the administration of oxyt(K3ics, manual exjjulsion of tiie child by {)ressure on tlie fundus, a precipitate use of the ft)rce})s, or, at tlie very least, tlie omission ot" means to ensure a slow dihitation of tlie vaginal entrance and the vulva during the birtli of the child ; and noaccouclieurs who will com- mit such faults and no midwives are likely to examine for a tear that is not visible on the skin, and, if they did,thev would liardly be compe- tent to remedy the injury. It will also be hard for the general })rae- ' J. II. Carsten.s, Detroit, Midi., Amrr. Jour. Ohsl., 1884, vol. xvii. j). 'J41. 326 DISEASES OF WOMEN. titioner to persuade the patient and her friends to allow him to per- form a protracted operation for a condition the importance of which is doubtful to their minds. But if cir(!um stances permit us to follow the dictates of science, the injury should be remedied by passing a row of deep sutures from above downward through the edges of the lateral tear. The needle should be carried well downward in the direction of the vaginal entrance and then up through the other lip, lifting up the j)elvic floor, as will be explained in describing Emmet's operation for old tears. Catgut is the best material, since it need not be removed. A single cutaneous suture dis})oses of what is not united by the preceding sutures (Fig. 223). For the latter silkworm gut or silver wire is preferable. If the sphincter ani is torn, its ends should be brought together with two sutures — one corresponding to the innermost, and the other to the outermost, fibers, inserted in the way to be explained below in describing Emmet's method for old tears. Serrefiues are removed on the fifth day, sutures in the incomplete laceration on the eighth day. In the complete laceration the cutane- ous are left in nine or ten days; the rectal take care of themselves, catgut being dissolved and silk being allowed to cut through; the, vaginal, if silk has been used, are removed after three or four weeks, when the perineum is strong enough to allow the use of a speculum. The same applies to the deep laceration of the vaginal ring. Intermediate Perineorrhaphy. — If several days have passed since the laceration took place and the surface lias begun to granulate, it may yet be made to grow together. It is for this purpose scraped with the edge of a knife, washed with lysol water, and united as described above with serrefiues or sutures. Union by first intention has in this way been obtained in operations performed from one to three weeks after delivery. The subcutaneous tear of the levator ani muscle might be treated in the same way as the open tear in the same locality, after making an incision through the mucous membrane down to the torn ends of the muscle. ]>ut, so far as I know, nobody has undertaken this at the time of delivery, and I think such a procedure would meet with considerable opposition, not only in the public, but even in the pro- fession. This accident is therefore left until injurious consequences develop, and is tiien operated on according to the rules presently to be laid down. B. Old Lacerations. — If the lacerated perineum has not been united by the primary or intermediate perineorrhaphy, the so-called secondary perineorrhaphy will in many cases become necessary. In the meantime the patient has not only suffered, but some of the conditions enumerated above may have formed, and the shape of the parts involved has been changed. Instead of Ijroad surfaces corre- DISEASES OF THE PERINEUM. 327 spending to each other, we have irregularly contracted cicatrices. In some way or other new raw surfaces must, therefore, be produced, and, as the cicatrices are much smaller than the original tear, it becomes necessary to borrow from the surroundings and unite tissues that do not belong to each other in the normal condition. Of the very large number of operations invented for the repair of old lacerations of the perineum, we will describe three only, one of which, in our opinion, will give satisfaction in any case : 1. Incomplete Laceration. — a. Colpoperineorrhaphy.^ — The patient is in the dorsal posture. The object is to remove the whole vaginal wall and the mucous membrane of the vulva over a surface on the posterior part of the vagina and vulva, bring tlic two halves together from side to side, and at the same time lift the })osterior wall of the vagina uj) against the anterior. According to the amount of tear and relaxation of the vaginal entrance and the perineum, a point (Fig. 224, A, a) is chosen in the median line more or less high up toward the cervical portion. This is pulled forward and upward with a ])air of bullet-forceps with catch. A small nick is made on the inside of each labium majus near the edge at such a distance from tiie clitoris that there will be left proper space for c<)})uhiti()n {/> and c). Imaginary lines are drawn from tliese two jioints to the first, and another j)air of buUet- forcej)S is introduced where the line intersects the furrow on either side of the vagina (d and e). A blunt-pointed pair of scissors, bent on the flat, and with the concave side turned toward the operator, are then introduced at c, the nick made on the left labium, and ])ushed up to e and down to tiie line of demarcation between the mucous membrane and the skin and over toward the other side. Next, they are introduced at h, the nick made on the right labium, and used in a similar way until this lower ])art, somewhat shaped like a trapezoid, is denudecK The uiore we a])proa('h the base (h c) the more the miu'ous membrane adheres, and it may be bound to the miderlying parts by cicatricial tissue, which may recpiire small nicks with the scissors. The fin)) is cut off along the lines e r, c h, and b (1. The scissors are now turned upward from e and <l to a, and from one side to another, loosening the wiiole vaginal wall irom the underlying conne(;tive tissue and rectum in the sha])e of a dome. This is very easily done by taking hold of the lower part of" the flap. Finally, tlu; uj)per ])art is cut loose by carrying the scissors in a curved line with the convexity turned outwiinl. ( )n account of the foreshortening, it is dillicult to represent in a draw ing the ' TJiin ()j)or;itioii Iki^; Iiccii pra'itially (icvolopccl in (he course of a Cfntury. lloiix, niefPenhach, \\v^:\r, and many otiiors liavecontrilmtcd to it. 'I'lic writer lias also tn-eii much int«'reste<l in it, as will bo seen by compariiif^ tlu; tiirec niitions of tliis work — the description dillerin;? in all of them. I desorihe it here as 1 now perform it. 328 DISEASES OF WOMEN. Fig. 224. ^.Garrigues' Colpoperineorrhaphy : the four lower turns of the suture slant downward toward the entrance : 2J, the dome- shaped part of the wound shown in A having been closed, the perineal sutures are inserted— 2 is all buried; 3 and 4, partly free— all in a .slanting direction ; C, deep and superficial perineal sutures tied. DISEASES OF THE PERINEUM. 329 shape of the denudation. It somewhat suggests a policeman's hel- met. The wound is closed by a running suture of medium-sized catgut, going ^ of an inch out from the edge and under the whole surface. The first few turns are carried horizontally, but the fol- lowing are made to dij) a little toward the perineum, so that when tightened they will raise the posterior wall of the vagina forward and upward. This suture is continued until the lines / c and / b (Fig. 224, B) have the same length us g c and ff b. Then a silkworm-gut suture (2) is carried deep under the wound from a point about half an inch from the median line [g) and f inch from the edge of the denuded surface up under the wound, about two- thirds of the distance from the end of the closed line (/), and down to the corresponding point on the other side. A second suture (3) is inserted midway between the first and the point c, brought out on the edge of the denuded surface at h, between the inner and middle third of c, reinserted on the other side at i, and brought out on the skin. Finally, the last suture (4) is inserted near the outer edge of the wound (c), brought out at k midway between h and c, reinserted at i, the corresponding point on the other side, and brought out on the skin below b. These three sutures are not tightened until all are put in and the surface well irrigated. Tlie direction given to the sutures ensures a perfect adaptation of the edges, and makes the surfaces that come in contact sufficiently broad to form an ex- cellent substitute for the original perineal body. In order to pro- tect the rectum from being wounded, it is necessary to keep the left index-finger in it while passing the sutures. A large curve<l Hagedorn needle can be used in most cases. Finally, in order to ensure perfect adaptation of the edges, a couple of fine superficial silk sutures arc introduced on the perineum, between the deep sutures (Fig. 224, V). At the end of the ojx'ration, all inner (vaginal and })erincal) sutures lie in one C-shaped line. 'J^lie effect is to narrow the vagina and vulva, lift the ])()steri()r wall, and interpose a strong perineal body between the vagina and the rectum, much in the siiajK' of the one shown in Fig. 49, ]). 54, whi(;h body is suspended from above by its indirect attachment to the bones of the ])elvis. After some time tiie ])arts look so natural that one can liardly see that an ()])er- ation has b<'en jtcrfonued, and the ])erineum may even stand the test of (!hildbirth. I reiii(»ve the niiddhi j»erineal suture on the fifth day, as there is danger of a fistula forming, the others on the eighth. Jhirird Cfifi/iif Siifin-cs. — Some ])refer to (!h)se the whole wound with buried catgut sutures, either int(>rrupted or continuous. Tiie latter is begun at the uj>|)» r en<l of the triangle, and the first circle closed with a knot, leaving the end .'> inches long. '^Fhis end is seized with a j)aii of fbrcej)s and ])ulled u])ward by an assistant, 330 DISEASES OF WOMEN. which facilitates the introduction of the remaining sutures very niucli. The needle is introduced through the edges of the mucous membrane and under the raw surface until the tension becomes too great, when the suture is continued in the depth of the wound down to the vaginal entrance. From this it is carried upward, forming a second row of buried spirals, after which it is brought down between the edges of the nuicous membrane, and finally doAvn the perineum. It is tied as stated in describing tier-sutures (p. 237). b. Tail's Flap-xpllitlnrj Operation} — The j>atient is placed on the table in the dorsal position, with knees drawn up by Clover's Fk;. 22"). yiS^. Tail's Perineal Flap-splittmp; Opt ration for Incomplete Laceration (MacPhatter). crutch or Robb's leg-holder (p. 208). The left index- and mid- dle fingers are introduced into the rectum. One blade of sharp- pointed scissors, bent on the edge, is pushed in in the median line, midway between the anus and the posterior commissure, to a ^ Tail's priority has ))een contested, and I nnyself saw Demarqiiay operate by the flap-method, in Paris, in 1872. many years before anybody had heard of Tait's opera- tion of this kind ; but tliere can be no doubt that revival and simplification of the operation are due to the great gynecologist of Birmingham. One difficulty in describing his operation arises from the fact (hat he has per- formed it in different ways, and that those who have seen him operate have given very different descriptions of it — c. ;/. Maephatter (Amer. Jour. ObsL, Nov., 1889, vol. xxii. p. 1146) and Munde {ibidem, July, 1889, p. 673). In tlie text I describe it as I have performed it myself with good results. DISEASES OF THE PERINEUM. 331 depth of about | inch. It is next pushed over to the patient's left side in a curved line ending at the anterior edge of the labium majus, at a point situated at such a distance from the clitoris that there is left just room enough for copulation. All these tissues are cut through with one sweep of the scissors. These are now brought back to the starting-point, turned with the points to the right, and a similar incision is made on this side. Tiie wound gapes, and is made to gape wider by pulling the cut surfaces apart. If arteries spurt, thev are caught with pressure-forceps and may be tied with catgut (Fig. 225). A handled needle, slightly curved near the end, is pushed through the skin yV inch outside of tlie wound, and about ^ inch behind the anterior end of the incision,^ passes under the cut surface, emerges on the boundary-line between the cut surface and the inner portion of skin (vaginal flap), is carried over to the other labium, reinserted at the corresponding point, pushed under the right cut surface, and out through the skin -^^ inch outside of the wound. A piece of silkworm gut 10 iuclics long is drawn through the eye of the needle ; the latter is pulled back and freed from the suture, the two ends of which are held together with a pressure-forceps, and thrown up on the abdomen. Another suture is introduced in a similar way | inch farther back. One of the sutures ought to catch the end of the vaginal flap. One, two, or three more, according to the size of the. wound, are introduced under the whole cut surface behind the vaginal flap. In tightening the sutures care is taken to adapt the cut surfaces against each other. The outer flaps of each A on the two sides are turned outward, and the inner turned inward, and when the sutures are tightened the flaps are in this way approximated as plane surfaces, and so tiiey unite. If there is much redundant tis- sue to dispose of, the vaginal flap is turned forward and a special suture passed through its whole width, or it may even be necessary to cut out a V-shaped piece of it before uniting it. Between each two of the deep sutures a superficial silk suture is put through the skin alone. The original Tait operation is by far the most expeditious peri- neorrhaphy, and results in the formation of a thick and broad beam between the anus and the vulva. If there is not nuicli prolapse of the posterior wall, it is also sufficient, and its rapid performance recommends it in cases in wiiich several operations have to be per- formed in one sitting. Tait's operation lias been modified by using a scalpel and sej)a- rating the flaps to greater depth. Then it becomes also necessary to use a full curved needle and needle-holder. ^ Tait teaches to insert the needle well within the margin of the wound f /)(".vn.vs of Wovien, i. p. ()7), but in my hands the sutures cut through if placed in that way, and the skin is not accurately brought together. 332 DISEASfJS OF W03fEN. c. T. A. Emmet's Operation} — The aim of this operation is to lift up the pelvic floor and dispose of a so-called reetocele. The patient is in the dorsal position, with bent knees and with feet held up by two assistants. First Step. — The top of the reetocele (Fig. 226, A, a) is caught with a tenaculum and held by an assistant over to the left side of the vulva. Another tenaculum is inserted at the caruncula myrti- formis on the right side (b). A third tenaculum is inserted at the posterior commissure (c). Finally, a fourtli tenaculum is inserted at d; that is, a point so far up in tlie side sulcus of the vagina that Fig. 220. Diagram of T. A. Emmet's Operation for Incomplete Laceration of the Perineum. it does not yield on being pulled down. The four tenacula being pulled in divergent directions, a rhomboidal })art of the mucous membrane of the vagina is put moderately on the stretch, and the isosceles triangle, a d b, denuded with two snips of curved, rather sharp-pointed scissors from below upward. Next, silver sutures are put in, forming curves, or rather angles, the to]) of which points down toward the vulva (Fig. 227), the operator guiding himself by introducing a finger into the patient's rectum. While they are ^ This is Dr. Emmet's new operation. His old was like that for complete lacera- tion, with the exception of what has reference to the tear in the septum. DISEASES OE THE PERINEUM. 333 Fig. 227. being passed the assistant ahvays lifts the last, in order to check hemorrhage. Second Step (Fig. 226, B). — The top of the rectocele is carried over to the right side, and the triangle, afe, on the left side treated in the same way as the right. Third Step (Fig. 226, C).— The pa- tient's feet being lowered to the top of the table, the surface, a b e g — that is, all the mucous membrane between tlie top of the rectocele, the tMo carunculpe myr- tiformes on the side of the vaginal en- trance, and a curved line running a quar- ter of an inch inside of the posterior circumference of the rima pudendi and parallel with it — is denuded, and sutures are put in from side to side. One is car- ried througli the two caruncles, h and e, and behind the tip of the tongue of mu- cous membrane left between the denuded surfaces, a. Three or four more are put in from side to side, as seen in the figure, all entering on the mucous membrane inside of the skin. Emmet's Suture for lifting the Pelvic Floor: The needle ia in- trortiK'ed at a, pushed out at 6, and when it has been pulled through, it is reinserted at b and carried to c. Fig. 228. Outorbridge's Suture. The BUtures are numbered in the order in wliich lli'V arc tied, not inserted. Fniirfli Sff'p. — The sutures are twisted, beginning from thetojisof the triangles, d and /', and ending at //, cut oil', and ])ent backward 334 DISEASES OF WOMEN. into the vagina. When all are closed they form a Y, and are all in the vagina and the vulva, while the skin is not touched at all. This operation reduces the parts to a condition much like the normal in appearance ; but it requires more time, more skill, and better assistance than the other operations. Outerbridge ' has simplified Emmet's operation by using only three sutures. The first is medium-sized catgut, 10 to 12 inches long, armed with a straight cervix-needle at each end. It is passed from the end of the central undenuded tongue to the upper end of the lateral denu- FiG. 229. 'X«' Tait's Perineal Flap-splitting Operation for Complete Laceration (MacPhatter) : 1 to 1, first transverse incision ; 1 to 2, incisions forming vaginal flap ; 3 to 4, incisions forming rectal flap. dation on both sides. It is not tied, but the needles are thrown up over the symphysis. Next, the second suture, which is of silver wire, is passed from the highest point of the denudation on the labium majus, under the whole wound, across to the corresponding point on the other side. Then the first suture is tied, and from this now cen- tral point one of the needles is passed under the denuded surface and brought out on the inside of the labium, half an inch above the lowest point of denudation. The other needle is passed in the same way to the corresponding point on the other labium. i!so\v this lower suture is drawn tight and tied. Finally, tiie silver suture is twisted. The bowels are moved on the third dav, and the silver suture removed on the eighth (Fig. 228). ' Outerbridge, Med. Record, April 21, 1894, vol. xlv. p. 493. DISEASES OF THE PERINEUM. 335 2. Complete Laceration. — a. Tali's Flap-splitting Operation (Fig. 229). — The cicatrix in tiie recto- vaginal septum being put on the stretch by separating the buttocks, the scissors are run from one end of it to the other (Fig. 230, A), making an incision about | inch deep, by which are formed a vaginal and a rectal flap. From each end of this first incision another is carried at an obtuse angle, forward and outward, into each labium majus for about an inch (Fig. 230, B, a d and b c), and, again starting from the ends of the first, a fourth and fifth, one-third of an inch in length, are made backward Fkj. 230. A a b Diagrams illustrating Incisions and Sutures in Tail's Operation for Complete Laceration of the Perineum : A, first incision following the cicatricial line between rectum and vagina, the ijuttoclis being stretcheii (nattiral size); li. incisions to anterior edge of labium majus and outside of anus (witiiout tension) ; '', flaps thrown upand down and puton the stretch ; sutures inserted in the order marked : the third c<)rresi>onds to tlie angle lietween tlic flaps (the bottomof the first incision); the first goes riglit through theendsof tlie lirokcn sjiliinc- ter ; I), continuous catgut suture carried througli the edges of the wound, now turned into the vagina (the same as the upper edge of the Hrst incision, li, a b). and outward (Fig, 230, /*, a f and h r) just outside of- tiie ends of the torn sphincter. The vaginal Hap is licld u])\vanl, the angles d a h and r }> a being pulled by forceps diagonally nj)\vard and inward toward the median line. Th(! rectal lla|) is held downward, the angles/ a h and v h a being pulled in a similar manner downward and inward. Thus the lines f//and re l)ecom(! curved with their convexity turned outward (Fig. 230, C, (la and hb). The needle is carried as described above, with this difference, that it is mnde to emerge Mi)ont \ inch iVom 33G DISEASES OF WOMEN. the bottom of the wound aud enter at the corresponding point on the opposite side (except the hindmost closing the spliincter, which is buried altogetlier). Tlie sutures are inserted, beginning at the anus and going forward. Finally, the middle of the raw edge a b, now situated in the new-formed vagina, is seized with a tenaculum, and the wound closed with a continuous suture of fine catgut (Fig. 230, D). li there has been much loss of tissue by previous denuding opera- tions, deep relaxing incisions should be made parallel to the ramus of the ischium on both sides. The sutures are left in for three or four weeks, the bowels being kept loose. The ends of the sutures should be left rather long (J inch), as they become deeply imbedded aud are hard to find. For the complete tear, Tait's operation is, in my experience, superior to all others. It is easy to perform, takes a short time, and yields perfect results. b. Hegar^s Operation} — The patient is in the dorsal position. The buttocks are pulled aside and the anterior vaginal wall lifted U]) with Sims's speculum. A sponge soaked in antiseptic fluid, or a pad of iodoforni gauze, may be introduced into the rectum, and withdrawn before the last rectal sutures arc introduced. A tenaculum-forceps is introduced at x (Fig. 231) in the median Fig. 231. c d Ilegar's Operation for Complete Laceration of the Perineum. line of the posterior vaginal wall, three-quarters of an inch above e, which is the upper point of the tear in the recto-vaginal partition. Two other pairs of tenaculum-forceps are introduced at a and b on tiie lower edge of the labia majora, at tlie distance from the clitoris where we want the posterior commissure to be, slightly above the anterior end of the cicatrice marking the situation of the old perineal body. These three points are now })ut on the stretch, and, beginning ' For simplicity's sake I leave tliis operation under lietrar's name, hut it has evolved gradually in the hands of Dieflenbaeh, Simon, and others. DISEASES OF THE PERINEUM. 337 at X, the operator draws, with the })oint of a scalpel, a curved line to 6, with the convexity turned toward himself. Next he continues the line from b to d, with a slightly convex curve outward, down to a point just outside and behind the pit marking the torn sphincter. Next, an exact counterpart of this line is drawn on the right side. Finally, the pit is seized with a tenaculum and cut off with blunt scissors curved on the flat, and the strip continued along the whole edge of the rent in the rectum over to the corresponding point on the other side, so as to remove all the cicatricial tissue. The mucous membrane is seized in the middle of the incision, at e, with a toothed forceps, and the scissors pushed up under it to the limits of the sur- face circumscribed with the scalpel. Where it meets with resistance small nicks are made through the resisting ti&sue. Finally, the flap thus formed is cut off with the scissors. It is rarely necessary to use hemostatic forceps on bleeding vessels. If so, the tissue grasped between the jaws of the force})s should be cut away before closing the wound, in order to avoid having any dead tissue in its depth. Fine silk (braided No. 2) is best for the rectal sutures, silkworm gut for the vaginal and perineal. Only round needles, straight an<l curved, 2 inches long, should be used for the vagina and rectum. Cutting needles make large holes in the soft tissues to be united, which seriously interfere with success. The first suture is put in a little below x, and followed by several others parallel to it running from side to side under the whole raw surface, x m n. In order to avoid penetrating into the rectum the movements of the needle are guided with the finger in the intestine. Next, some rectal sutures are inserted. The needle is introduced on the rectal surface ^ inch below the top of the rent, and at the same distance from the edge, and (!arried under the raw surface above the rent, pushed out in the malian line, reintroduced with the point turned down in the same ])lace, carried under the raw surface on the right side, and out on the rectal surface at a point corresponding to that of entrance. The following rectal sutures are merely pushed in a slanting line from the rectum to the raw surface outside it on the left side, intnxluced in the corresponding place on the right side, and carried down through tlie rectal wall. Thus raw surfaces are brought in contact and the edges turned into the rectum. The last two sutures are made to embrace the ends of the broken s|)hincter. The rectal sutures are (piite close to one another, about -^ incii apart, superficial alternating with deep. Next, the lines m (i. and n h are l)r(>ught together witii sutures ^ inch apart, alternately a deej), reaching half- way under the raw surface", and a superficial. Finally, four or five are |)la(XHl rather superficially on the perin(Mim. Every suture is tied and cut imme<liately when inserted, the ends being turned iij) out of the wav of the follo\vin<r suture. 338 DISEASES OF WOMEN. If the tear is over 11 inches long, the upper half of it is stitched from the vagina alone, the se])tuin being too thin for a vaginal and a rectal row of sutures. The lower half is treated as described above. Silk threads entering the rectum become easily conductors of septic material, and small abscesses form, which often result in a small recto- vaginal fistula. Tliis may be obviated by using buried submucous catgut sutures (Fig. 232). These sutures are introduced from the raw surface a quarter of an inch from the edge to be united, and pushed out on the same surface quite near the edge, inserted on the corresponding point near the opposite edge, and pushed out a quarter of an inch from the edge on the raw surface. The vaginal sutures Fig. 232. Submucous Sutures (Lauenstein) : r, rectum; v, vagina. are put in in the same way, and finally the perineum is closed with silver-wire or silkworm-gut sutures.' Dr. Hirst, of Philadelphia, has modified Hegar's operation (Fig. 233).^ He closes first the rectum, as a rule, with four sutures, tlie last two of which unite the ends of the broken sphincter. Next, he inserts a suture surrounding the whole tear in the rectum, which suture strengthens the rectal sutures and forms a barrier between them and the vaginal and perineal sutures. Finally, the vaginal wound is closed with four sutures, and the perineum with three. He uses silkworm-gut, which is knotted in the rectum and shotted in the vagina and tlie perineum. In a very extensive denudation it is often an advantage to wliip the whole denuded surface together with a two-tier running catgut suture, beginning at the upper end of the vaginal denudation, run- ning down the deeper part of the wound, just short of the rectal mucous membrane, and returning in the vagina to a point opposite the original insertion, so that the two ends are joined by a single ' f!;irl Lauenstein, Centralhlatt f. Gyndk.. 1886, vol. x. p. 50. ^ 1). ('. Hirst, University Medical Mayazine, Jan., 1899. DISEASES OF THE PERINEUM. 339 knot. Naturally the catgut suture must be inserted after the inter- rupted silkworm-gut sutures are all in place. Fig. 233. ■,i j.-- ,'■* 't ■■ 1 ^M ^ A^*%^ 11 J WmJk^M T i I-mT r?^ ^1 !■ ■ — ^ S "^^ -■^-4W»->»- - ^ y ■sap '/; /^Pf 1 4 A The suture for a foiii])lele laeerutioii nf the perineum: A, A, the barrier or splint suture (Hirst). c. r. A. EinmeCs Operation. — Special care is taken to get the entire Fici. •2:!4. Diagram of Broken Spliinctcr Ani Muscles (T. A. Emmet): DC. first suture: HA, second suture. ends of the broken s{)hincter brought together. The above-men- 340 DISEASES OF WOMEN. Fig. 235. tioned pits marking these ends are seized with a tenaculum and removed, together with a strip of mucous membrane on the posterior vaginal wall and the internal surface of the labia majora, as in Hegar's operation. The first suture (Dr. Emmet uses always silver wire) is inserted a quarter of an inch behind and inside the end of the broken and retracted sphincter muscle, which now forms a convex surface (Fig. 234), and carried under the denuded surface parallel to the rent in the recto-vaginal septum, so as to unite the innermost fibers of the sphincter (Fig. 235, C, D). The second suture (A, B) is inserted at the outer end of the broken sphincter and carrial around the rent in the septum, parallel to the first. These two sutures when closed bring the two ends of the broken ring together, and unite it at the same time with the lower end of the septum. Next, a couple of sutures (Fig. 236, 3 and 4) are brought from the perineum under the whole de- nuded surface over to the other side, the uppermost comprising the end of the un- denuded part of the vagina. The last but one (5) goes through the labium majus, emerges near the side sulcus of the vagina just on the line of demarkation between the pared and unpared surface, enters the Fig. 236. Diagram of Broken Sphincter Ani (T. A. Emmet), showing how the ends are brought together by tightening the sutures. Diagram for Emmet's Operation for Complete Laceration of Perineum : R, rectum : r, vagina ; P, perineum. The figures mark the order in which the sutures are inserted. corresponding point on the other side, and emerges on the skin opposite the point of entrance. The la.st (6) unites the tops of" the denuded surfaces on the labia majora. DISEASES OF THE PERINEUM. 341 If the rent in the recto-vaginal septum is ova^ one inch long, it should be diminished by denuding the vaginal surface near the edges, down to the sphincter, and introducing sutures from side to side. When these have been removed after about nine days, and the denuded surfaces have grown together, the above-described operation for the closure of the sphincter and perineum is performed. Outerbridge uses his above-described three sutures after having overstretched the sphincter and united the edges of the gut either with continuous or interrupted catgut sutures, taking care to insert one suture through the ends of the broken sphincter. Preparaiion and After-treatment. — In regard to preparations for any of these operations for lacerated perineum, the reader is referred to what has been said in the chapter on Treatment in General (p. 205). The bowels are emptied and the labia are shaved, but the hairs on the mons Veneris need not be interfered with. The knees are kept tied together for two weeks. The diet during the first few days, until the bowels have been moved, should be exclusively albuminoid (milk, beef extracts, raw oystei-s, and eggs), so as to have as little lecal matter as possible. As a rule, some pain will call for small doses of morphine (gr. \-\) ; otherwise opiates should be avoided, as they render the feces hard. The patient may lie on her back or her side, but should move slowly and with the assistance of her nurse. On the morning of the fourth day laxol ' (fl,"iij) is given. When the patient feels that evacuation is near, four ounces of olive oil should be injected into the rectum. In this way an easy, loose movement or two are brought on. Thereafter every morning just enough laxol (about ^ij) is given to have one easy movement. The urine should be drawn with a catheter. AVhen, after a few days, there appears some discharge, a vaginal injection of carbolized water (oSS to Oij) should be given morning and evening, and, in com])lete laceration, half a ])int of lukewarm water injected at the same time into the rectum. In consecjuenee of the pressure exercised by the sutures against the granulation tissue formed around them, it is not rare to see the discharge be(;ome bloody. Then a vaginal injection of li(i. ferri chloridi, .^ss to a ])int of water, should be given three times a day. If the ])atient is troubled with flatus, nuieh relief is aflorded by the occasional cautious introduction of" a lubricated soft- rubber rectal tube of the size of the little finger. As a rule, ])erineal sutures nuist be removed at the end of a week (comj)are Tait's method) ; vaginal, whi(;h are difficult to reach with- out risking the destruction of the union in the perineum, are left in for three to four weeks, or more if necessary; rectal are left to them- selves. In removing vaginal suttu'es a virginal Sims speculum and ' Laxol is prepare<l from castor oil, but is easier to take and just as etieetive. 342 DISEASES OF WOMEN. Hunter's depressor (p. 149) will be found very useful. The ends of each suture are seized separately with the suture-twister and lifted a little. Great care should be taken to insert one of the points of a pair of pointed scissors into the loop, and cut close up to the entmnce of the stitch-canal. Tiie sutures should be removed from below upward, and when the rent begins to bleed the removal of the others siiould be postponed. But by using chromicizcd catgut we avoid all trouble in removing sutures from the deeper parts. The patient may leave the bed after two or three weeks. Coition should not take place for two months. CHAPTER II. Garrulity of the Vulva. Under the queer name "garrulity of the vulva" has been de- scribed a condition which is characterized by the entrance of air into the vagina and its ex])ulsiou with a noise from the same. Another name for the same ])heuomenon is flatus vaginalis. Etiology. — It is a rare disease, which can only develop when the vulva and the vaginal entrance gape. It may be due to tears of the perineum and vaginal entrance, episiotomy, loss of flesh, and vari- cose veins in the vulva. Treatment. — The indication is to diminish the entrance to the genital canal by the performance of one of the operations describtd above for laceration of the perineum, or by excision of cicatrices and union by suture. CHAP TEE III COCCYGODYNIA. Under the name " coccygodynia " are united different and par- tially unknown pathological conditions, the common feature of which is intense pain at the coccyx, whence it may radiate into the peri- neum, the hips, the uterus, and the bladder. .Pathological Anatomy. — Sometimes there are palpable diseases or deformities of the coccyx, such as caries, fracture, ankylosis^ too great a length, luxation, or other displacement. In other cases the condi- tion is combined with diseases of the uterus, ovaries, or rectum. In a third class it is of a purely neuralgic nature. It is not unlikely that the coccygeal " gland " (p. 105), with its exceedingly rich nerve- supply, has something to do with it. Still, this gland is found in DISEASES OF THE PERINEUM. 343 both sexes and at all ages, while the disease is never found iu man, and is exceedingly rare in childhood. Etiology. — The disease is only found in women, especially adults who have borne children, but occurs also in virgins, and very rarely in children. By far tlie most common cause is childbirth. As a rule, it appears after tedious labor with long-sustained pressure, tears, or straining of muscles or ligaments, or after instrumental delivery ; but it may also begin before delivery, and is then probably due to the })ressure of the head against the last two sacral and the coccygeal nerves. Tlie disease is sometimes due to violence from without, such as a kick, a fall, or horseback riding, or to exposure to cold, especially in individuals suffering from rheumatism. Sometimes it seems to be a reflex neurosis due to muscular contraction of the sphincter ani, the levator ani, or the bulbo-cavernosus muscles, such as is found in eon- sefjuence of painful caruncle or hemorrhoids. Symptoms. — Severe pain is felt in sitting, especially in sitting down or getting up ; nay, the tenderness may be so great that the patient can only sit on one-half of the nates, near the edge of a chair, using her hands to get up and down. All movements of the coccyx and tlie ligaments and muscles attached to it, intluced by walking, riding, defecation, coition, etc., increase the ])ain enormously. Diagnosis. — The condition is easily recognized by placing the pa- tient on her left side and introducing the index-finger into the rectum, while the thuml) rests on the skin over the coccyx. The slightest movement of the bone causes severe pain, and sometimes it may be possible to feel a diseased condition of the bone or the surrounding parts. Treatment. — The general treatment consists in tonics or antirheu- matics. Suppositories with five grains of iodoform or one-third of a grain of morphine; hypodermic injection of cocaine or morphine; inunction with ointments of venitrine or aconitine; blisters; cauteri- zation ; and galvanism or fiiradi/ation with the secondary high ten- sion current (p. 'J40) ; Ix'sidcs treatment of concomitant diseases in neighi)()ring organs, — have eacii effected cures. Jiut cases that have resisted all other remedies have yet been cured by the e.xiirpati<m of the coccyx, whether diseased or healthy. This o])eration, which may be called coccygectomy, is performed by placing the patient on the right side or on the alxlomen, introducing the index-linger of the h'ft iiand into her rectum, pressing it outward, and making an incision in tlie median line, abf)ut lour inciies long, and reaching from half an inch below the tip of'the (coccyx toone and a half inchesabove tlie base, down to the bone. Tlie soft tissues are j)ushed aside with a bhuit in- strument aiul a few touches of the knife, until the whole bone, inehisive of the projecting transverse processes of the uppermost vertebra, is laid bare. The attaciimcnts of the ijone throughout its whok; length are 344 DISEASES OF WOMEN. freely separated on each side, and the knife passed through the articu- lation with the sacrum and the lateral ligaments. The left hand is now disengiiged, and, armed Nvith Fergusson's bulldog- forceps, used to seize the bone, which is pulled firmly outward, while some flat, blunt instrument like Hay's director is passed behind it and severs all re- maining connections, except the tendon of the levator ani muscle, which has to be cut with a knife. In exceptional cases it may be- come necessary to sever the bone with a cutting bone-forceps or a small ^w. As a rule, there is not much hemorrhage, and the wound may be united by deep interrupted sutures (preferably silkworm gut). If there is much hemorrhage, it may be necessary to pack the wound with styptic cotton and let it heal by granulation. The coccyx in women is flat and shorter than in man, about two inches long, and forms a nearly equilateral triangle. When it is re- moved, we look into a deep hollow, at the bottom of which is seen the levator ani muscle, covered by the anal fascia (p. 97). The deep sutures ought to embrace all the edge, inclusive of the severed lesser sacro-sciatic ligament, but not the levator ani muscle. After the operation the patient is pulled down over the end of the table ; the wound is dusted with iodoform, covered with iodoform gauze and cotton, and a double spica is applied, inserting a piece of gutta-percha tissue so as to leave the anus and vulva free and keep the dressing clean. The sutures are removed after a week. CHAPTER IV. Hygroma. Under the redundant name of " perineal cystic hygroma " has been described a cystic tumor formed by an accunnilation of fluid in the cavities of the coccygeal gland. It forms a round, elastic, immov- able tumor, situate between the anus and the tip of the coccyx, and covered with normal skin. It may attain the size of a fetal head at term, annoy the patient by its size and weight, cause dyspareunia, and be a serious obstacle in the way of childbirth. I^iko similar tu- mors in other localities, it may become inflamed and form an abscess. Treatment. — If it resists the resolvent action of painting with tinc- ture of iodine, it may be emptied through a hydrocele trocar and in- jected with the fluid. Part of the skin and subcutaneous tissue cover- ing it may be cut off", the cavity packed with iodoform gauze, and left to fill by granulation, changing the dressing daily. The whole tumor has also been successfully extirpated. If suppuration has occurred, the cyst should be freely laid open from end to end with a bistoury, washed out with disinfectants, and filled with iodoform gauze. PART III. DISEASES OF THE VAGINA. CHAPTER I. Malformations.* A. Malformations of the Hymen. 1. It is doubtful if the hymen is ever absent. 2. Atresia hymenalis is the condition in which the hymen forms an imperforate diaphragm. It is probably due to an excess of growth of the hymen. Like a transverse septum situated higher up in the vagina, it prevents mucus, cast-oif epithelial cells, and menstrual blood from flowing out, and causes, therefore, an accumulation of blood or mucus above it. Such an accumulation of blood in the vagina is called hematocolpos ; in the uterus, heinatometra. If the blood is changed to pus, the conditions are respectively called pj/ocol- pos and pyometra. As a rule, the blood forms a thick, dark l)rown, tarry mass. Even in young children the closure of the hymen may give rise to a retention of mucus, forming a tumor which bulges out between the labia and obstructs micturition and defecation. But much more commonly it is at the time of puberty that the accumulation of men- strual blood causes pain, increasing at each menstrual periwl, and tiie formation of a tumor gradually growing in size from below up- ward. First the vagina is distended, then the cervix, the two form- ing one globular mass, on the toj) of which is felt the undilated body of the ut(!rus, until, finally, this also takes part in the dilatation. The tubes form sometimes large tumors fillwl with blood {hematox(tl- pinx), which do not always communicate with the uterus, the blood not being pressed up from the uterus, but coming from the mucous mem- brane! of the tubes themselv(>s. ])iverti(!ula may bulge out from them. They may be divided into a series of three or four compartments by internal lamella; growing from the wall or i)y bands of peritonitic; ' I have treated tliis siiliji^ct somewhat more extensively in Atrn'riain Sij.<lcm of Oyiuxolorpj, vol. i. pp. 2o7-278. .145 346 DISEASES OF WOMEN. origin, forming constricting rings without, and they may be bound to the Avail of the pelvis by strong adhesions. The tumor formed by the vagina and uterus may nearly fill the pelvic cavity and press on the rectum and the bladder, causing dysuria and dyschezia. The hymen becomes thick and fleshy, as do the walls of the vagina, especially the muscular coat, above any transverse septum wherever located. The pent-up blood may form a tumor in the perineum as large as the fetal head, which flattens out the frenulum and is continuous with the skin on the distended perineum and labia of the vulva. In front there is found the meatus urinarius. This tumor is fluctuating. Strangely enough, imperforate hymen may be found combined with pregnancy, wliich can only be explained by supposing that there has been a minute opening, admitting spermatozoids, which has closed after menstrual discharge has stopped. Diagnosis. — The bulging of the perineal region is pathognomonic. Often an occlusion is found at the lower end of the vagina, just above the hymen, but this does not form a tumor in the perineum, and on close inspection the hymen with its oj)ening will be found below and in contact with the occluding membrane. Prognosis. — In itself, the condition leads to rupture of the vagina, uterus, or tubes, and even operative interference is fraught with danger. Treatment. — Spontaneous rupture through the hymen being very rare, and rupture of the tube being much more likely to occur, an outlet must without delay be given to the accumulated fluid. The operation consists in making a crucial incision tiirough the closed hymen or in cutting it off along its insertion. This may simply be done with knife or scissors. If the membrane is removed, it is well to stitch the edges of the wound together. Some prefer the thermo- cautery or galvano-cautery for slitting open the diaphragm, in order to protect the wound against infection. Xo pressure should be exer- cised on the tumor, as it might lead to rupture of the tubes. But the uterus should be washed out with a warm alkaline solution (bicar- bonate of sodium or liquor potass^e, oSS— Oij), which dissolves the thick blood, and, after that has been removed, with a disinfectant. Permanent irrigation of the vagina has been used as after-treatment, which prevents the entrance of air and keeps up some degree of pressure. If hematosalpinx can be made out before the operation, it is best first to perform laparotomy, and remove the distended tubes with the ovaries; or vaginal hysterectomy and salpingo-oophorectomy may be preferable. Dangers of the Operation. — The membrane being comparatively thin and of easy access, there is no difficulty in incising or removing it; but, simple as the operation appears, it has more than once proved DISEASES OF THE VAGINA. 347 fatal. The two dangers are rupture of the tubes and sepsis, the latter of which, being so much more common, must cany greater weight in deciding the measures to be adopted. In regard to the first, the operator should, as stated above, abstain from pressure, or may per- form preliminary extirpation of the tubes. In order to avoid the second, a large opening should be made and the accumulated fluid washed out immediately. The use of the cautery, sutures, and per- manent irrigation is also based on the fear of sepsis. 3. Abnormal Openings. — Instead of having one opening, the hymen may have two placed side by side. If the bridge between them is broad, the condition is called hymen hiforis or hymen bifenes- tratus. If it is narrow, it is called hymen septus. Sometimes such a partition grows out from the anterior or posterior wall without reach- ing the opposite wall, which formation is called hymen subseptus. There may also be many small openings, a condition known as hymen cribriformvi. ■ 4. Double Hymen. — The hymen may be double in different Avays. One may be placed above the other, which probably is only due to the presence of a transverse septum in the lower part of the vagina. One may also be placed beside the other, the vagina itself being double. Treatment. — If the sliape of the hymen interferes with coition or childbirth, the condition is easily remedied by removing the septum, making an incision in it, or removing the whole hymen. 5. Fleshy Hymen. — Sometimes the hymen is so thick that it is not ruptured in attempted coition, but constitutes an insurmountable obstacle. This may cause considerable pain and become a source of much nervous irritability (vaf/inismus). The condition is very easily remedied by cutting the offending part off with curved scissors and stitching the edges of the wound together. B. Malformations of the Vac/ina. 1. Atre.sia and Stenosis. — The word "atresia" means a lack of lumen, and ought only to be used in speaking of a complete closure of the vagina, whereas "stenosis" means narrowness, and may ])ropcrly be applied to any condition in which the vagina has not its proper width. Jiut authors often use the word atresia even when there is an opening in the septum obstructing the vagina, and then divide atresia into complete and incomplete. The lower end of the vagina may be closed by a thin membrane {septum retrolnpnenale), or one or more solid transverse septa may be found higher up in the vagina, or, finally, there may be a coinplete absence of the vagina. In such cases the uterus is commonly absent too, but sometimes a more or less normal uterus may be found beyond the tiasue where the vagina (»ught to be. 34xS DISEASES OF WOMEN. Complete vaginal atresia gives rise to retention of the menstrual flow and the other conditions described above in treating of atresia of the hymen. It prevents impregnation, and, if the septum is situ- ated low down, it causes more or less dyspareuuia. The pouch may, however, in course of time, by continued use, become considerably deei)er. Sometimes connection takes place in the urethra or the rec- tum, especially the former, and, strangely enough, such considerable dilatation causes only exceptionally incontinence of urine. Much more conunon than this complete closure is the presence in the vagina of a transverse se})tum with one or more 0})enings. Some- times the opening is so minute that it can only be discovered at the time of menstruation, when blood may be seen trickling through it. Under such circumstances impregnation becomes possible, and we may, therefore, find labor obstructed by a transverse septum in the vagina, presenting an obstacle similar to that of an imperforate hymen. Different theories have been ])roposed in order to explain the formation of transverse septa in the vagina. One is, that adhesion and coalescence have taken place between opposite walls of the vagina ; another is, that the Miillerian ducts failed to be tunneled in the place where the diaphragm is found ; and, according to a third, the vagina above the septum is formed by one of these ducts, and below the septum by the other. A general narrowness of the vagina may be due to an arrest of development — a condition often combined with an infantile uterus — and sometimes only one of the Miillerian ducts is developed, while the other disappears, so that there really is only half a vagina. This narrowness may cause dyspareunia. So far, we have only had in view congenital conditions, which con- stitute what is called malformations. But similar septa may be acquired. They may be the result of sloughing and adhesion conse- quent upon disease, or be the result of violence, strong acids, or even a red-hot iron, being applied in the vagina by fiendish wretches. Treatment. — The reader is referred to all that has been said about the dangers of imperforate hymen and its treatment. But, besides what has been said tiiere, the transverse septa and the absence of the vagina offer special features. The thinner the septum is, the more the treatment will be like that for imperforate hymen ; the thicker it is, the more it approaches that for absence of the vagina, which we shall now consider. If there is an incomplete transverse septum between an up])er and a lower dilated part of the vagina, the narrow part may be in- cised longitudinally, in the direction of the axis of the vagina in several places, the narrow part bluntly dilated, and the edges of the incisions sutured in a transverse direction, producing a shorter but wider canal. DISEASES OF THE VAGINA. 349 In a case of absence of the vagina, the first thing to do is to make a thorough examination, preferably under ether, by using simulta- neously a hand on the abdomen, a finger in the rectum, and a cath- eter in the bladder, and, taking the presence or absence of menstrual molimina into consideration, to find out whether the patient has a uterus and ovaries or not. If there is a uterus, and the menstrual flow takes place internally, an operation becomes imperative, in order to save the patient's life, and by proper care the new-formed vagina may be kept pervious. If the ovaries are also present, impregna- tion may take place after the formation of a vagina, but childbirth would be impossible, or so dangerous that i^ should be prevented by artificial abortion or abdominal hystero-salpingo-oophorectomy. If there is only a rudimentary uterus, but ovaries giving rise to moli- mina, abdominal oophorectomy should be performed. Modus Operandi. — In order to make an artificial vagina, the patient is placed on her back with her knees drawn up. The vulva is stretched from side to side. The mucous membrane is seized with a tenaculum, and a transverse incisi(m made midway between the urethra and the anus. Now the operator works his way slowly and very carefully up between the bladder in front and the rectum behind, using a pair of closed blunt scissors and his forefinger to tear the connective tissue between both, and keeping a metal catheter in the bladder and his left forefinger in the rectum, until he reaches the OS, which can be felt from the rectum. He introduces the scissors through the os, when the accumulated mucus and blood flow out. With a dilator he stretches the cervical canal about half an inch, and washes out the uterus with warm solution of bicarbonate of sodium (.5J-Oj) and after that Avith creolin (1 per cent.). A hollow glass plug (I ig- 237) in proportion to the size of the new- formed vagina is introduced into it, covered with antiseptic gauze and cotton, and held in ])lace by a T-bandage. I think it is an improve- ment to have a hole {(i) at tlie bottom of the i)kig in order to allow es(!ape of fluid, and one (h) on each side of the rim from which a string goes to the bandage surrounding the ]>elvis.' The wound heals over the plug, epithelial cells growing out from the vulva in the course of a month, during which time the plug is tiiken out and cleansed every day and tiu; vagina disinfected. li' healing is slow, it may be furthered by painting the raw surface once a day with a weak solution of nitrate of silver (gr. ij-.5J). The patient should wear tlu; plug daily for at least an hour during a whole year, but as this is tiresome and somewhat painful, she is liable to neglect it, and then the canal shrinks again from the uterus downward, and it b('<!omes necessary to dilate it gradually or rej)eat the ()j)(Tati<)n, '.fohn Reyndcrs & Co. , cor. Fourth ave. and Twenty-third st., liavo nuuic such plugs for me. 350 DISEASES OF WOMEN. which is still more difficult and dangerous than the first time, when the tissue yields more easily.* Other Methods for Keeping the Canal Open. — Instead of the per- manent use of the plug, some prefer, after granulation is well estab- FiG. 237. Vaginal Glass Plug. lished — say, the end of a mouth — to dilate with finger and speculum every two or three days — a very painful procedure. To cut out flaps of the surrounding skin and turn them into the new-formed vagina is not advisable, on account of the hairs growing on these parts ; but flaps of raucous membrane have been obtained from the vulva and used with success. Thus, Kiistner cut loose the ^ On Jan. 25, 1890, 1 operated on Annie K , American, fifteen and a lialf years old, for absence of vagina, combined with uterus unicornis. She had for some time complained of severe abdominal pain; had a temperature of 101° and a pulse of 128. The hymen was normal, but the vagina was only a quarter of an inch deep. Through the abdominal wall, the vagina, and tiie rectum was felt a hard, slightly elastic swelling, nearly filling the pelvis, especially in tlie left side, and extending up into the left iliac fossa. 1 had to form a vagina to the full length of my index- finger, 2h inches, and tliere was so little tissue between the bladder and the rectum that only a thin transparent membrane was left between the artificial opening and the rectum. Tliere was no cervix, but the os could be felt far upward and back- ward. Finally, I succeeded in introducing the scissors into the os. A considerable amount of thick j'ellowish mucus, mixed with old blood, flowed out. The tumor diminished, and was washed out as stated in the text. She imy>roved immediately, and made a good recovery, and menstruated three times while she was under my observation. Slie was ordered to use her glass plug one hour every day, but soon got tired of it. When I saw her again, about a year later, the upper lialf of the vagina had contracted again to the size of a cervical canal, just admitting the sound. On May 30, 1895, after slie had grown to be a big, stout woman and had married, I formed again a vagina in the same way as before. Ten months later there was still a vagina as long as the index-finger, and beyond that a probe could be introduced 1^ inch farther. Since she had not menstruated for four months, and ha<l pain in the left side, 1 advised abdominal hysterectomy, but she passed into other hands. DISEASES OF THE VAGINA. 351 labia minora to their posterior end, split them open by a longitudinal incision, and stitched them together so as to form a sac outside of" the vulva, which sac he then stitched to the artificial canal formed between the rectum and bladder. In another case he successfully lined the hollow with the mucous membrane of a part of the resected intestine of anotlior patient. The new-formed vagina has also successfully been lined with portions of the vaginae of other patients upon whom colpoperineorrhaphy had been performed.^ Dr. Burrage, of Boston,- in a case of absence of the uterus, formed two lateral and posterior flaps, and thus obtained a vagina 4^ centimeters deep, which by use was deepened to 5^ centimeters, and satisfied both the patient and her husband (Fig. 238). The orifice of the rudimentary vagina is shown on line ef. An incision was made along this line and prolonged at each end, so that Fig. 238. Formation of a Vagina (Burrapo) : a h f and r <i e, lines of incision for flaps fioni laliia minora; e rf and /6, lines of incision for perineal flap; r/, line of incision for excava- tion for new vagina. it m(;asured about 3 centimeters in length, splitting the riKliiucntary vagina into halves. With a finger in th<> re<;tum and a .m)Iuu1 in the urethra for guides, tlie recto-urethral s('])tum was split by dissect- ing with scissors and finger for a distance of 5 centimeters. At that point the finger in the wound was aj)))arently sej)ar:ite(l iVom the intestines by a sheet of jx'i'itoneum only, and it was impossible' to feel any tissue that might represent the uterus, ovaries, or tubes. In order to covc-r the raw surfaces fi)rmed by the dissection, fhips were formed as follows: The nymplue were cut off ;it n li :ui<i ' Mackenro.It, C-ntnilhl. f. Gyiwk., ISyO, No. '1\, p. :A(\. ^ W. L. JUirrage, Aim-r. Jour. M,<l. Sci., Marcli, IS'j;. 352 DISEASES OF WOMEK e g, and then incisions made through mucous membrane along the lines hfb and g e d. The two lateral flaps formed in this way were dissected free, and by so doing the nymphie were split from their posterior aspect and unfolded. The posterior flap, represented by the surface enclosed between the letters d e f b, was formed by dissecting deeply the tissues of the fourchette and perineum, so that this flap could be dragged upward and inward to cover the posterior surface of tlie new vagina. The strip of mucous mem- brane that had been the posterior half of the rudimentary vagina was dissected away, and the posterior flap anchored by suturing its tip at the uppermost part of the new vagina with a catgut stitch. In the same manner the two lateral flaps were disposed of. The little strip of mucous membrane on the anterior wall was utilized by stitching the lateral flaj)S to its edges. The operation was com- pleted by sewing together the edges of the mucous membrane and the stumps of the nymphae and at the places where the three flaps came into apposition, with fine interrupted sutures of catgut. The after-treatment consisted in keeping the vagina packed with iodoform gauze. After healing, a dilator was made of a rubber finger-cot stuffed Avith cotton. This was worn constantly, being kept in place by a T-bandage. The treatment of general narrowness consists in gradual dilata- tion by means of the bivalve speculum or plugs of glass or hard rubber, and the use of lubricants in attempts at coition. This same treatment is to be followed when the narrowness is relative ; that is to say, when the female organs are normal, but the husband has an excessively large penis. 2. Double Vagina. — The vagina may be divided by a more or less complete longitudinal partition into two halves, each of which corre- sponds to one Miillerian duct. Commonly, but not always, double vagina is combined with double uterus. The two halves of the vagina may be unequally developed, the larger one alone being used for coition. If this one is closed above, fecundation can, of course, not take place. Instead of a long partition there may only be found a more or less narrow band as remnant of the original septum between the Miillerian ducts. As a rule, a fully-developed double vagina does not give any trouble, and is discovered accidentally. If childbirth takes place, the septum is more or less completely torn. Treatment. — If the septum interferes with coition or impregnation, it may be split lengtliwise. Both halves are distended wath specula and retractors, so as to put the septum on the stretch, and then it is severed midway between the anterior and posterior walls by means of the thermo- or gal va no-cautery. DISEASES OF THE VAGINA. 353 A mere band oftener causes dyspareunia and dystocia than a com- plete partition, and may be severed with scissors. If there is any bleeding:, it is checked by cautery, styptic cotton, or tampon. If the band is fleshy, it is preferable to tie near the two ends and cut out the middle piece. Double Vagina icith Atresia. — Double vagina may be combined with atresia on one or both sides. If one side is pervious, men- struation and impregnation may take place, and the condition is, therefore, often overlooked for a long time. The right half is much more liable to be closed than the left. The uterus is with few ex- ceptions two-horned. Menstrual molimina, due to retention in the closed half, are pres- ent, combined with menstrual flow through the open half. The tumor formed by the retained fluid bulges very much into the latter, and may distend the vulva and interfere with micturition. The upper part of the tumor lies on the side of the uterus. The lateral atresia leads much more frequently to spontaneous rupture thaa atresia of the single vagina, and the perforation always takes place in the septum of the cervix uteri ; but this does not effect a cure. The contents are only partially evacuated, air and microbes enter, the stagnating fluid becomes i)urulent or putrid [lateral pyocolpo)^ and p}loinetra),i\n(\ causes inflammation and uktcration of the walls. The inflammation may extend to the tubes and the peritoneal cavity. At times the tumor increases again in size until, after great ])ain, a new discharge takes ])lace through the opening in the septum. Diaffnosia. — For diagnostic ])urposes, it is of importance tliat pressure on the vaginal tumor causes a jiurulent discharge through the OS uteri of the open half of the vagina. Lateral atresia has been taken for licinatocele, but the history of a chronic disease with monthly exacerbations, and the shape and ])osi- tion of the tumor, will help to avoid this mistake. In lateral atresia the tension of the wall often varies at ditl'crent times, and if it is not very gnsat, it is sometimes ])ossible to invaginate the lower ])art of the tmnor and feel the muscular ring formed by the os. If the septum is situated very high n|), the tumor may also be con- founded with cij.sl.s adherent to the utei'us or a iiii/oma. in the wall of the latter. An exploratory puncture may become necessary to settle the diagnosis. Treat innd. — Sims's speculum is introduced in the open halt', and thesej)tiim slit open with knife, scissors, or preferably thermo- or gal- vano-cautery. In cases of double atresia one side is lir-t opened, as in atresia of the single vagina, and allerward the septum incised. .'). lUiiul (jinals. — Imme(li:itely al)ove tli(,' entrance of the vagina, laterally, are occasionally found l)lind canals, which may be ;ui inch and a half long and wide enough to admit the little fmger. Tliev are 2.3 354 DISEASES OF WOMEN. lined with smooth mucous membrane, and are probably only unu- sually developed lacunae. They are without practical importance, except that they may become receptacles for gonococci. If the affec- tion cannot be cured with injections, it may become uece&sary to lay the canals open. 4. Faulty Communications. — Familiarity with the history of devel- opment (p. 81) allows us to recognize as consequences of developmental arrest certain abnormal conditions sometimes met with. Thus we have complete atresia — i. c. absence of any opening on the cutaneous surface leading into the intestinal or urogenital canal, while under the skin is found a common cloaca into which open bladder, vagina, and rectum. The next step in development is represented by cases where this cloaca has an opening on the surface of the body. The rectum opens apparently into the vagina or vulva (atresia ani vaginalis or vestibularis.) It may have a sphincter or not. In other cases the vagina and the urethra apparently open into the rectum, but in real- ity these cases are only modifications of a persistent cloaca. If the development has been arrested still later, the partition be- tween the rectum and the urogenital sinus may have been formed, but the urethra seems to open into the vagina. This is really due to a persistent urogenital sinus. Complete atresia is only found in non-viable fetuses. The other conditions hardly ever become the object of operative interference. If the rectum opens into the vulva or vagina, an artificial anus may be made; but if there is a sphincter, it may lose its innervation, and the patient be left in a worse condition than she was before. In very rare cases there is a normal anus, but a communication between the rectum and vagina higher up — a congenital recto-vaginal fistula. This may be closed in the same manner as the acquired fistula. It is likewise very rare that a ureter ope) is into the vagina instead of the bladder. This may be loosened and fastened with sutiu-es in the wall of the bladder.' CHAPTER II. Vaginal Enterocele. Vagixae Enterocele, or vaginal hernia, is a tumor formed by the intestines, and sometimes the omentum or <narv, by inverting the vaginal wall. Sometimes the protrusion takes place through an open- ing in the muscular coat of the vagina, so that there is a hernial ring, and the prolapsed intestine is only covered by the mucous membrane. Commonly this })rotrusion begins in Douglas's pouch, but it may also ' W. H. Baker, of Boston, New York Medical Jourrud, Dec, 1878. DISEASES OF THE VAGINA. 355 occur between the uterus and the bladder, or in the scar left by vaginal hysterectomy. It may extend into the posterior part of the labium majus, forming a vagino-labial hernia (p. 279). Causes. — The hernia may be caused by a fall, lifting a heavy bur- den, straining at stool, but most commonly it is due to pregnancy and childbirth. Symptoms. — In acute cases there is a sudden pain and feeling of a rupture. If the development is chronic, there is a dragging sensa- tion, constipation, and dyspareunia. No case of strangulation is known, but during childbirth a dangerous pressure is exercised on the tumor Avhen it is being pushed (lown in front of the presenting part. On examination, a pear-shaped, soft tumor is found protrud- ing in the lumen of the vagina or (lescending through the vulva. It increases on cough, can be pushed up into the abdominal cavity, may give a gurgling sound on handling, and, if accessible in front of the vulva, will give a tympanitic percussion-sound.' Diagnosis. — It has been mistaken for a uterine poh/pu.-^ — a mistake that seems impossible except in consequence of unpardonable care- lessness. It may be much like a vaginal cyst, but this does not diminish on pressure. Treatment. — The intestine may sometimes be reduced and kept up by some form of pessary, especially the more bulky ones, such as Hoifmann's, Fowler's, Garriel's, or a globe-sliaped one which will be described in treating of the uterus. Thomas has pcrlbrmed lapa- rotomy, inverted the sac, and fastened it in the abdominal wound. Perhaps colporrhaphy (p. 360) may succeed in retaining the intes- tines in the pelvic cavity. As a last resort, the sac may l)e opened, superfluous tissue cut away, and the edges united by interrupted sutures. Prolapse of the intestine into an unusually deep Douglas's pouch (p. 94) is a somewhat kindred condition, which may give rise to constipation, a sensation of weight, and other discomfort. The intes- tine may j)erhaps l)e kept up by one of the above-named l)ulky vaginal pessaries, li' this does not succeed and the condition causes <.'onsi(leral>le trouble, an incision may be made in tiie posterior fornix and the pouch closed by a contimious suture of catgut. ' On !ii'coiitit of the preat rarity of this aflection tlie foliowins; notes of the only case I liave ever met with may be of interest: Kliso V., set. 27, widow, nnipara, of robust appcaranee and excellent cfmstitutirin, applied at tlie (icrman I)isiiensary on < )ctol)er l(t, 1H!);>. Slu; had l)een perfectly well until three weeks before 1 saw lier, when she fell down into a cellar and struck tlu> riuht side of the abdomen against a wooden box. Since then she had bloody dischar^'e from tiic ulcriis and alKlominal jiain. I'y vajrinal examination the uterus was found retrotlexed and very tender, hut it eoidd ea-ily be replaced, in the left and posterior w:dl of the fornix was found a soft elastic tumor of the size and shape of a hen's cj;j^ and very tender. It could be i)artially jiushed iiack into the abdominal cavity, wlieu a sharp oval ring was felt surroun<liiig it, probably an opening in the |(elvie fascia. 356 DISEASES OF WOMEN. CHAPTER III. Prolapse of the Anterior Wall of the Vagina ; Cystocele. Any part of the vaginal tube may be pushed into its own caliber, so as to form a swelling there. We have already mentioned entero- cele, which is the rarest of these prolapses, and in which the intestine is found in the tumor. Little less rare is a bulging out of the lateral walls, because these normally are drawn to one side by the attachment of the levator ani nniscle and bands of connective tissue interspersed with elastic fibers extending to the rami of the pubes and the ischium. The most common of all, on the contrary, is a }irola])se of the ante- rior wall, and on account of the shortness and tightness of the con- nective tissue between the vagina and the bladder this latter organ always follows the anterior wall of tlie vagina more or less in its descent. Causes^ — By far the most common cause of this disj)lacement is childbirth. During pregnancy all the constituent parts of the vagina awd the surrounding connective tissue grow and become infiltrated with serum. During childbirth these parts are bruised and torn. During tiie lying-in period, and when the patient gets up, the weight of tiie accumulated urine presses on the yet soft and yielding anterior vaginal wall. If the perineum has been ruptured or the vaginal ring (p. 320) is l)roken or over-distended, there is a still greater lack of support from below. The increased weight of the vagina itself, due to subinvolution, contributes also to the prolapse. Cystocele may occur apart from childbirth, in consequence of excess in venery, or even in virgins who work hard and are underfed; but such cases are exceedingly rare. Symptoms. — The condition gives rise to frequent and often imper- fect micturition. The bladder is not entirely emptied, and the retained urine undergoes alkaline decomposition and produces catarrh. When the patient lies on her back with flexed and separated knees, the anterior vaginal wall is seen forming a round swelling protruding through the vaginal entrance. By means of a catheter we can easily satisfy ourselves that this swelling contains the base of the bladder. If the condition is complicated with procidentia uteri (see below), thC' bladder forms in front of the uterus, which hangs between the thighs, a large soft swelling. Treatment. — Elinor degrees of cystocele may be successfully treated with astringent su])positories or injections, by electricity, by rc})airing a torn perineum and a posterior vaginal wall, and by a general tonic regimen. More pronounced cases call for direct sur- gical interference. These operations are called anterior co/porr/icip/ij/^ DISEASES OF THE VAGINA. 357 Fig. 240. It may be median, lateral, or bilateral. The median operation may be performed according to Sims's method. Sims's Method (Fig. 239). — The patient is in the dorsal position, the knees drawn up and separated by means of Clover's crutch or Kobb's leg-holder (p. 208). The posterior wall is pulled down with Garrigues's spec- ulum, a bullet-forceps is fast- ened in the median line just below the point corresponding to the inner end of tiie urethra, which is marked by a trans verse ridge (Fig. 240), and another at the lowest point near the cervix. The opera- tor seizes the mucous mem- brane of the anterior wall of Fio. 239. Diagram of Sims's Cystocclo OiHsrution : duiiudirtlon by cnttiiiK 'iff the loiiKiliHliiial strii)S of mucous membrane witfi scissors. Pawlik's Vafrinal TriRone, correspond inp to Lieutaud's ves- ical trifrone: A. lal)ia minora: O, meatus urinarius ; O'.O', uretliral lcdf?e ; .S, S, lateral folds correspondingtothesides of the vesical trigone; /{, fold corresponding to the basis of the vesical trigone ; V, vaginal portion of uterus. the vagina somewhere near the lateral sulci with two tenacula, and draws them together. Thus lie ascertains how much tissue is redun- dant, and makes a suiji with a pair of scissors on each side, in oi'dcr to mark the great<'st width of tlu." surface to be denuded. Just out- side of these |)oints he inserts a tenaeulum-forceps, so that the wlioh; surface to be ])ared may i)e ]iut on the stretch. With a ])air of scis- sors curved on tlie flat a strij) of mucous membrane about ] inch wide, and extending from the lower forceps to the uj)per, is cut olf. Similar strips are cut ofl' j)arallel to the first on the right side until 358 DISEASES OF WOMEN. tlie landmark is reached. Then the same procedure is repeated on the left. In this way an elliptical surface, with the long axis in the direction of that of the vagina, is denuded. Next, a running suture of chromicized catgut (Leavens, No. 2) is passed under the whole denuded surface, uniting the edges. It is very convenient to use irrigation instead of sponges (pp. 186, 209, and 238). This metliod leaves a linear cicatrix in the median line. Walking'' s Method ^ is lateral or bilateral. According to its author, laceration of the anterior vaginal wall is unilateral or bilateral. It is usually submucous, and occurs at or near the insertion of the fascia into the bony pelvis. The location and extent of the tear are detected by touch and by inspection of the change in the shape that occurs in the anterior vaginal wall, which normally presents a convexity cor- responding to the urethral curve, a marked concavity corresponding to the trigone of the bladder, and a straight line or slight convexity from this point to the uterus. For Watkins's operation the patient is placed in Sims's position, and the anterior vaginal wall exposed with his speculum. A point of the mucous membrane to the side of the urethra, near its meatus, is caught with a tenaculum. The denudation is carried from this point, along the antero-lateral M'all of the vagina, to a point beyond the prolapse. This point corresponds to the internal opening of the urethra, or the denudation may extend even as far back as the lateral aspect of the cervix uteri. The breadth of the denuded sur- face is dependent upon the extent of the urethrocele and cystocele, all the redundant tissue of which it should take in. The denudation is made on one or both sides according as the laceration is unilateral or bilateral. Silkworm-gut sutures are passed, beginning at the uterine end of the denudation, from side to side in a curved line which has its convexity outward and forward. Each suture as inserted is tied, and traction is being exerted toward the cervix while the next suture is being introduced and tied. The sutures should include as much connective tissue as possible, care being taken not to injure the bladder, the ureters, or the urethra. After passing the trigone of the bladder the sutures should be passed deeply into the lateral wall near its insertion into the pubes, and as deeply into the anterior vaginal wall as the increased thickness of the vcsico-vaginal septum from tliis point outward will permit. The stitches may be removed after a week or be allowed to remain for two or three ' weeks. It is claimed that this operation cures the incontinence of urine which sometimes is a distressing feature of cystocele and urethrocele. (Compare Pawlik's operation for incontinence, under Urinary Fistula.) ^ T. J. Watkins of Chicago, 111., Jour, of Gynecology, Toledo, O., Aug., 1891, vol. i. No. 5, p. 305. DISEASES OF THE VAGINA. 359 Gersuny's Method. — Experience having shown that in the course of time the linear cicatrix formed in Sims's operation is apt to give way, Gersuny has tried to fortify it by the following procedure : A median incision is made from the cervix to the tuberculum vaginaj. The flaps are separated from the bladder as far as, or beyond, the limits of the cystocele. Next, the wound corresponding to the base of the bladder is closed with three or four tiers of running forma- lin catgut sutures, which produce a longitudinal ridge in the blad- der, which can be felt with a sound. Finally, the superfluous tissue is cut off from the vaginal flaps, and the edges stitched together. For the last stitch interrupted sutures are preferred.^ In any of these operations the bladder should be emptied every four hours. If the patient can urinate, she may be allowed to do so. If not, the urine is drawn, preferably with a soft-rubber catheter. The jiatient should stay in bed three weeks. Cyntopcxy. — A new French operation for cystocele, by which the anterior wall of the bladder is fastened to the abdominal wall, has been performe<l several times with success. Tiie bladder is injected with Ave ounces of solution of boraoic acid. A transverse incision 2| inches long is made through the abdominal wall in the hypogastric region. Two catgut sutures are carried through the lower edge of the wound except the skin, then through the outer layers of the anterior wall of the bladder, and through the upper edge of the wound. After tying these sutures the skin is stitched together. During the first six days the catheter is used twice a day only. CHAPTER IV. Prolapse of the Posterior Vaginal Wall; Rectocele. Next to the prolapse of the anterior wall, that of the posterior is the most common form of pmlapse of the vagina. It is commonly called "rectocele," but this name is only used correctly, if the })ro- lapse contains the rectum, which, as a rule, is not the case. The con- nective tissue between the rectum and tlic vagina being much longer and looser than that between the bladder and the vagina, the latter slides away from the rectum, doubles up, and forms a round swelling bulging out through the vaginal entrance. IJy pinching this fold and by intro- du(;ing a fing(ir into the rectum we can easily satisfy ourselves that this is so, JJut in tlie course of time the anterior i-ectal wall, lacking its normal support in front, may become distended and form a pouch descending inside of that formed by tlie vagina. ' R. fiersiiny, Centralbl. /. Gyndk., 1897, vol. xxi. No. 7, p. 177. 360 DISEASES OF WOMEN. Etiology. — The causes are similar to those enumerated for cysto- cele, except the weight of the bladder, for which here is substituted constipation. Si/mptoms. — The symptoms are a similar dragging sensation. Con- stipation, besides being a cause of rectocele, is a sequence of it, and may lead to proctitis with ulceration of the mucous membrane. When the patient lies on her back with separated knees, a globular swelling, formed by the posterior wall of the vagina, is seen protruding through the vaginal entrance — a swelling that increases in size when she bears down or stands. Treatment. — Posterior colporrhaphy consists in the denudation on the posterior wall of an elliptic surface similar to that described in treating of cystocele, but is seldom resorted to. On account of the looseness of the connective tissue between the vagina and the rec- tum, instead of cutting the mucous membrane off in strips, the whole vaginal wall may be separated bluntly and circumscribed with curved scissors. As a rule, the perineum and the vaginal entrance have been injured, and the operation called for is colpoper- ineorrhaphy. (See pp. 327 and 336.) By a little ingenuity, inter- mediary forms of denudation between that of posterior colporrhaphy and colpoperineorrhaphy may be adapted to particular cases. Vaginal Prolapse and Inversion. — When the whole vagina sinks down all around, the condition is particularly called prolapse of the vagina, and if this goes so far that the whole tube is turned inside out and forms a sausage-shaped mass hanging between the thighs and sur- rounding the prolapsed uterus and bladder, and sometimes the rectum, it is called inversion. The mucous membrane, exposed to the air, becomes dry and scaly, and, on the other hand, the thrown-off epithelial cells, if the parts are not kept clean, form a white, malodorous smegma in tiie pouch be- tween the prolapse and the perineum, which irritates the mucous mem- brane and gives rise to vaginitis. This condition is connected with prolapse of the uterus, and will be considered in treating of that disease. CHAPTER V. Injuries; Thrombus or Hematoma. The tear in the hymen produced by the first coition may cause a severe and even fatal hemoi-rhage. If an artery is found spurting, it must be tied. In other cases an application of, or injection with, liquor ferri will suffice to check the hemorrhage (pp. 175 and 176). In order to prevent its recurrence, the tear should be given time to DISEASES OF THE VAGINA. 361 heal, and some vaseline applied before intercourse, until the vaginal entrance is dilated. Much more serious are the tears in the vagina that occur under similar circumstances. The wall has been found torn from the vaginal entrance to the fornix. Tears are occasionally produced dur- ing coition with women wlio have had frequent intercourse or even borne children, but then tliere is a strong suspicion, sometimes cor- roborated by confession, that some hard object has been introduced simultaneously witli the pern's. Such a tear may also be caused by coition with old women where senile atrophy has taken place, or with women afflicted with stenosis or atresia of the vagina or double vagina. Transverse tears of the fornix have occurred during coition after the operation for lacerated perineum. In such cases it is prob- ably due to the shortening of the posterior wall. Sometimes the lesion is due to unusual jwstures during tlie act. During childbirth the vagina is quite frequently torn. In most cases the lesion extends only through the mucous membrane, and is then of little importance, but it may ])enetrate through the whole thickness of the wall into the surrounding connective tissue. In regard to these lesions the reader is referred to works on obstetrics. The vagina may also be injured by falls on a pointed object, by attacks of horned animals, etc., or by obstetrical and surgical opera- tions, especially the extraction of the child by means of the forccj)s, the replacement of an inverted uterus, or the removal of a large uterine fibroid. Even a fall with the abdomen against the sharp edges of a st(?j) on a staircase has indirectly caused a tear of the nuicous membrane of the vagina.^ Sipnptoms. — These tears are, of course, accompanied by consider- able pain. They may cause severe hemorrhage. Sometimes the intes- tine prolapses and may become gangrenous, leaving an ileo-vaginal fistula. There may also remain an opening into the peritoneal cavity, through which the intestine can slip out and be brought back. All the sympton)s of septicemia may be developed. A permanent recto- or vesi(;o- vaginal fistula may remain. J'rof/no.si.s. — Witli proper surgical help the ])rospects are good. Trcaduent. — The vagina is cleaned of clots, spurting arteries tied with catgut, the edges of the wound united with sutures, and a few })le<igets of icKJoform gauze placed over the wound. These are re- newed ubout every three days, Thromhui^ or hniKtioiiia is a swelling formed by the extravasation of l)lood in the coinieetiv(> tissue surrounding the vagina. It is nearly always due to childbirth, and the reader is, therefore, referred to works on oi)stetrics for information concerning it. ' Centralbt. fiir (iyniik., 1802, No. ?>\, xvi. p. 014. 362 DISEASES OF WOMEN. CHAPTER VI. Foreign Bodies. Foreign bodies are by no means rare in the vagina. Most com- monly they are objects used by the patient herself in masturbating or as preventives of conception. Sometimes they have been placed there for therapeutic purposes by a physician or a midwife. In rare cases their introduction is due to brutal jokes or acts of vengeance. The most divei-se objects, such as pessaries, sponges, hairpins, sticks, needle-cases, snuff-boxes, glasses, pomade-jars, bottles, etc., have been introduced and remained for months or years in the vagina. The writer has found an imperforate shot. Intestinal worms and insects have found their way to the same place. Symptoms. — According to their size, shape, and length of sojourn foreign bodies may give rise to a great variety of symptoms. The patient complains of pain in the pelvis, the hy|)ogastric and the lum- bar regions, or shooting down along the inside of the thighs. A purulent and offensive discharge, dysuria, dyschezia, and dyspareunia are developed. The presence of the foreign body may cause ulcera- tion ; gangrene ; fistulous communications between the vagina and the urethra, the bladder, or the rectum ; peritonitis ; and pelvic abscess. Diagnosii. — Often the patient has forgotten the origin of her trouble or is restrained by shame from telling it. Besides a vaginal examination with finger and speculum, often the examination through the rectum or wnth catheter or finger in the bladder may be of great help in arriving at a diagnosis. The object may change much in shape by the deposit of calcareous matter around it. It may become entirely hidden from view by burrowing into the tissues, which close over it, or migrate into the abdominal cavity. A sponge giving rise to hemorrhage and a foul discharge has more than once been taken for a carcinomatous cervix. Treatment. — The treatment consists in the removal of the foreign body and in combating the inflammation and other disorders caused by its presence. While the first indication in most cases is simple enoutih to fulfil, in others all the ingenuitv of a surgical mind and the resources of a good armamentarium are required. As a rule, the object can be removed through the vulva, but in exceptional cases it has been found advantageous to withdraw it through the rectum or the bladder. Lengthy objects occupying a transverse position must be seized near one of the ends. Large objects must sometimes be broken with shears or lithotriptic instruments. Considerable help is often afforded by introducing a finger into the rectum and hooking it over the body from above. In regard to hairpins, it nmst be remembered that tliev almost invariablv are introduced with the ends DISEASES OF THE VAGINA. 363 pointing downward to the vulva, which ends must be freed before the pin can be extracted. Sometime^ an incision must be made to reach the body. If the vagina contains pieces of broken glass with sharp edges, the walls should be lubricated and plaster of Paris poured in, which will settle around the pieces and form one mass witli them that may be withdrawn without cutting the vagina.' The second indication will in most cases be met by using antiseptic and astringent vaginal injections. Sometimes a consecutive endo- metritis calls for treatment, and in rare cases fistula operations, or even laparotomy, may be required. CHAPTER VII. Vaginitis. Vaginitis is tlie word commonly used in America to designate inflammation of the vagina, but as the suffix -itis is of Greek origin and vagina Latin, exception has been taken to it. German authors have substituted the term colpitis, and English sometimes use elytritis. Under the term " vaginitis " are comprised such very different conditions that it is necessary to admit certain divisions and sub- divisions of the subject, which is done in many diffi^rent v.ays by different authors choosing different standpoints. Thus we distinguish between acute and c/u'o?i/c vaginitis, the differ- ence being not only limited to the time the disease lasts, but also to the greater and lesser intensity of tiie symptoms. Tiie acute form commonly ends in less than a month ; the chronic has no definite limit. A vaginitis is called primary when it appears first in the vagina; secondary if the inflammation invades tliis organ from another ])art of the body, especially the vulva, the uterus, the rectum, or the urethra. In regard to the chief feature of the disease we distinguish between catarrhal vaginitis, characterized by a discharge from the mucous membrane; exudative vaginitis, in which a solid inflammatory exu- dation takes place either on the surface of the mucous membrane (croupous vaginitis) or in the depth of the same {diphtheritic vaginitis) ; and ph/cf/moiious vaginitis, also called dbisectiiir/ vaginitis or jjeri- va</initix, in which the inflammation has its scat in tlu; connective tissue surrounding tin; vagina, and leads to the severance; and expul- sion of^ the whole tube. As sulxlivisions we unite under tlie term "catarrhal" the following: * K. J. Levis of Pliiladelphia. 364 DISEASES OF WOMEN. forms of vaginitis : 1, the granular (also called follicular, or glandu- lar) ; 2, the .simple ; 3, the adhesive; 4, the gonorrheal; 5, the exfoili- ative ; and 6, the emphysematous vaginitis. To the diphtheritic vaginitis belongs the dyseuteric. A. Catarrhal Vaginitis. — Pathological Anatomy. — In granular vaginitis the epithelium as a whole becomes thicker, the papillae be- come larger, and circumscribed groups of small round cells are formed under tiiem and send proliferations into thera. When tiie papillae increase in length and width, the ej)ithelial cover immediately over tliem, and the tongues it sends in between them become thinner ; at the same time the blood-vessels are much developed. These cell- groups and the swollen papillae on their toj) form on the surface of the vagina circular prominences as large as lentils. In simple catarrhal vaginitis a similar process takes ]ilace on a smaller scale, so iliat the cell-groups and the swollen papillae remain under the level of the epithelium. In the chronic form pigment is imbedded in the deeper cells of the epithelium. In the lowest portion of the normal vagina are found numerous cocci and bacilli ; the upper portion is free. The acid secretion of the vagina kills the microbes or deprives them of their virulence ; but under favorable circumstances they regain it and may cause inflammation. The adhesive form is especially found in old women ; but clinically a similar condition is also observed in young children. The vagina is spotted or striped, being tlie seat of ecchymoses and superficial ulcerations, and there is great tendency to coalescence between the surfaces lying in contact with each other. The microscope reveals similar cell-groups under the surface as in the two other forms, but here the whole epithelial layer is lost over the infiltrated spots. In the discharge is commonly found an infusorial animalcule called Trichomonas vaginalis. Even in the secretion of the normal vulvo- vaginal tract in children there are found epithelial cells, in some quite a number of pus-cells, numerous bacteria, cocci, diplococci, bacilli, and spirilla, but never the gonococcus of Neisser, which is pathogno- monic of gonorrhea. It is a diplocoecus found in the interior of the epithelial cells and of pus-c()rj)uscles, and is characterized by becoming decolorized by Gram's method.^ * Gram's Method. — The cover-glass smeared witli the substance to be examined is passed quickly through the flame, and placed from two to three minutes in a solution of gentian violet, prepared according to the following formula: to 10 cc. of water add 2 cc. aniline oil, shake well, and filter through moist filter-paper. To the clear ani- line water obtained add 1 cc. of 97 per cent, alcohol and 1 cc. of a saturated alco- holic solution of gentian violet. The excess of fluid is drained ofi' from the cover- glass with filter-paper. Next, the cover-glass is placed for five minutes in Gramas iodine solution, which consists of iodine, 1 part ; iodide of potash, 2 ; water, 300 ; and then placed directly into alcohol, 97 per cent., in order to wash out all the coloring matter. (Henry Heiman, "A Clinical and Bacteriological Study of the Gonococcus (Neisser)," New York Medical Record, June 22, 1895.) • DISEASES OF THE VAGINA. 365 Etiology. — Old women are liable to have vaginitis without any other particular cause than their age. Young children often suffer likewise from vaginitis, due to the accumulation of old epithelial cells in the vagina, whence they do not easily escape on account of the smallness of the opening in the hymen. The great afflux of blood and formation of new tissue that take place in pregnancy lead very frequently to it. Even menstruation is liable to cause it, or make it worse if already present. Anemia and scrofula predispose to it. Often it accompanies eruptive fevers, especially measles. Direct causes are exposure to cold, especially sitting on a cold stone ; exces- sive coition, masturbation, or rape; the presence of foreign bodies, especially pessaries; the use of too hot or too strong injections; opera- tive interference ; the irritation caused by urine or fecal matter enter- ing the vagina through fistuke, or by an acrid discharge coming down from the uterus or from a pelvic abscess. The real morbific agent is, according to modern science, to be sought in infection with bac- teria. By far the most common cause of the acute form is infec- tion Avitii gonorrheal discharge in whatever way the infecting principle may enter the vagina. Syinptovis. — The patients have a disagreeable sensation of heat in the vulva and the vagina. They have pain in the j)elvis and the groins, which increases by walking or any other exercise. They com- plain of general malaise, and are oft(Mi feverish. Micturition is ac- companied by a burning sensation. Defecation may also be painful. The vagina is so tender to the touch tiiat the introduction oi'a specu- lum causes great ])ain, and sexual intercourse becomes imjjossible. The mucous meml)nine is red and swollen. At first it is dry, but in a day or two a discharge begins, mIhcIi first is nuicoid, then muco- purulent, and finally consists of thick creamy j)us. The vaginal ]H>r- tion presents a dee|) red arecjla around tiie os, which easily bleeds on being wnped, and a plug of thick muco-puruU'nt matter is seen in the cervical canal. J>y |)ressing on the urethra a di"op of pus is commonly brought out. The inflamiiialion is aj»t t(» remain long in the upper part of the vagina. Sometimes it sj)reads to the vulvo-vaginal or the inguinal glands, where it may end in res(»lution or induration, or cause the formation ol' an abscess. At the menstrual periods the symptoms of vaginitis are apt to l)ecome more marked, and a decided exacerbation is caused by pregnancy and chiklbirlh. In r/iroiilr r(if(irr/i(i( r(i(/iiiili.s the symj»tonis have much less intensity. The patient may, however, complain of a sensation of heaviness or smarting. Tiie chief" symptom is the dischai'ge, which sometimes is mon; purulent, in other cases more mucoid. The vagina is of a dark red, bluish, or grayish color, and often the seat of ero- sions. The niuc(»us membrane is thickened, folded, and often more or less j»roIapsed. 366 DISEASES OF WOMEN. Vaginitis may have the chronic type from the beginning, or the chronic may be a continuation of the acute form. Gonorrheal vagi- nitis is particularly liable to become chronic, because the infecting element is retained in the urethral ducts, the ducts of the vulvo- vaginal glands, or the small vestibular glands. The chronic form is often secondary, due to an irritating discharge trickling from the uterus, or of constitutional origin in scrofulous or chlorotic women. It is a frequent accompaniment of old age, and is quite common during pregnancy. Diagnosis. — The signs of vaginitis are so distinct that the disease is easily recognized. Still, the physician must be on his guard in order not to mistake for vaginitis a discharge f7'om the interior of the icomb due to endometritis, chancer, fibroma, or other affections of the uterus, or a pelvic abscess discharging its contents through a fistulous tract into the vagina. The differential diagnosis between gonorrheal and simple non-viru- lent catarrh is of great importance, both as to treatment and from a medico-legal standpoint, but science, as a rule, does not warrant us in going beyond a diagnosis of probability in this respect. We try to obtain the history of the case. Very often the mere behavior of the patient furnishes already a strong suspicion that her conscience is burdened with guilt, and by following this hint the physician may be able to elicit a confession. Sometimes it is possible to examine the man who is the source of the infection. The preseiice of purulent ophthalmia in children of the family makes the gonorrheal nature of the vaginitis probable, the germs of the disease having been carried to the children on fingers, sponges, towels, etc. On the other hand, the presence of a gonorrheal vaginitis in a child may be traced to the same disease in the mother or other female member of the household, and thereby an innocent man, who is accused of rape, saved from unmerited ])unishraent. There is no feature in the disease itself that with absolute certainty can serve to prove whether it is of gonorrheal origin or not. Severe cases of common catarrhal vaginitis produce a pus that is contagious. Certain circumstances, however, are more frequently found in gonorrhea than in non-specific catarrh. The mucous membrane is of a particularly bright red color ; the discharge consists of thick creamy pus; as a rule, the cervical canal and the urethra are implicated ; there is greater tendency to inflammation of Bartholin's glands ; the development of vegetations, if the patient is not pregnant, speaks also in favor of the specific nature of the case. The presence of recent tears and bruises may be of great importance as evidence of rape, in which connection it may be worth mentioning that, unfortunately, there reigns a wide-spread superstition among uncultivated men that a gonorrhea is cured by connection with a virgin, which often leads to assaults upon little girls. DISEASES OF THE VAGINA. 367 The most conclusive proof is thought to be the presence of gonococci, but there are as yet such great differences between the views of bacteri- ologists on this subject tliat it would be unjustifiable to base on the bac- teriological investigation alone an assertion which may cause the con- viction of an innocent man accused of rape or cast the opprobrium of infidelity on a faithfid wife. From a clinical standpoint we must say there is always doubt as to the specific or non-specific nature of vaginal catarrh, and therefore, when called upon to give an opinion as experts, we must give the accused the benefit of the doubt. I have seen cases of urethritis followed by epididymitis where it was as sure as any human thing can be that neither husband nor wife had worshiped strange gods, and I have also seen a newly-married girl, of good family, set. 17, get all symptoms of gonorrhea, inclusive of salpingitis, although the husband was examined by a prominent andrologist, who declared there were no gonococci, but many other kinds of cocci, in his urethra. Prognosis. — Non-virulent catarrhal vaginitis is, as a rule, not a dangerous disease. The acute form yields readily to treatment : the chronic form may be protracted through yeare. Gonorrheal vaginitis is a much more serious disease than gonorrhea in men. It is true that urethritis, on account of the wideness, shortness, and compara- tively straight course of the canal is cured more easily than in men, even without treatment, the mere gush of urine serving the purpose of a thorough cleansing. But, on the other hand, the disease is apt to linger in the folds of the vagina, in the deep depressions of the plicfe j)almatfe of the cervical (^anal, in Bartholin's glands, in the urcithral ducts, and in the smaller vestibular glands, so that it is hardly possible to j)rogn()sti('ate its duration. If it extends up through the uterus and the tubes to the peritoneal cavity, it becomes not only a disease hard to cure, and sometimes calling for cajjital operations, but it jeopardizes of itself the life of a patient. Kveu in children it has l)e('oine nccessiiry to remove the appendages of the uterus on account of pvosalpinx due to gonorrhea. Apart from the danger to life and health, it is likely to cause sterility by closure of the tulx's or by imbedding the ovaries in exudative inflammatory masses. If the woman conceives and gives birth to a child, the chances of her catching ])uerperal infection are mucli increased, probably because the presenc(,' of" gonococ(;i facilitate the development of pyogenic microbes, and there is great danger of ophthalmia develop! nic in the child. Trcdliiunt. — I'atients affected with severe acute viiginitis should stay in bed for eight or ten days, or at least lie quietly on a lounge, riiey should be given a saline aperient. Their diet should be bland in (|uality and mcMleiate in amoinit. A'aginal injections of plain hot water .should be given, and in order to reach all the recesses of" the 368 DISEASES OF WOMEN. vagina it is best to stretch it by means of a wire speculum — e. g. Blakeley's resilient speculum. If tlie tenderness is so great that no instrument can be introduced, much relief is experienced by frequent hot alkaline affusions of the external genitals (borax or bicarbonate of S(xla 3j to Oj, with addition of tinct. opii 5J). To the water used for injection may be added emollient or aromatic substances, such as lin- seed meal or chamomile flowers. When the pain and tenderness sub- side and the discharge diminishes, bichloride of mercury (1 : 2500) or chloride of zinc (1 : 100) are used. In pregnant women it is better, on account of the risk of merciu'ial poisoning, to avoid the corrosive sublimate, and use creolin or permanganate of potassium (1 per cent.) instead. Still later it is well to paint the affected part of i\ni vagina with nitrate of silver in substance or in a strong solution (3ss-5j) twice a week. If the uterus is affected, that should be treated sepa- rately. If it is not, a tampon of absorbent gauze with astringent substances mixed with glycerin, such as subnitrate of bismuth (1 : 4), boroglyceride (1 : \Q), tannin (1 : 8, see p. 183), is introduced, and changed every day. Iodoform gauze has also a very good effect, but has an offensive and tell-tale odor. After the nitrate of silver has been used several times, powdered boracic acid may be introduced through a speculum into the fornix vaginae, and retained by means of a tampon. In regard to the treatment of the accompanying urethritis, see p. 287. AntihlennorrJiagic drugs (ol. santali, bals. copaivse, and cubebs) are less well borne by women than by men, and should, therefore, be given in somewhat smaller doses. They should only be used in the sub- acute and chronic stages. In chronic vaginitis astringent injections and applications are used. Extr. piui Canadensis, used on tampon, is praised. For chronic urethritis small rods made of iodoform and cacao-butter are intro- duced and squeezed against the walls. If the gonorrheal poison lurks in glands and ducts, these must be slit open, touched m itli pure carbolic acid, and dressed with iodoform gauze. For further infor- mation the reader is referred to the chapter on Leucorrhea (p. 268). Exfolintive, or Epithelial, Vaginitis is a rare disease. It is mostly combined with exfoliative endometritis (membranous dysmenorrhea) and found in hysterical women. The vagina shows the usual clianges due to catarrh. Membranes as much as an inch in diameter, and con- sisting of the epithelium and blood-corpuscles, are, with larger or shorter intervals, sometimes as often as twice a week, found lying loose in the vagina, or are easily detached from it without causing bleeding. At other times the membranes consist of coagulated fibrin, including blood-corpuscles and epithelial cells. Astringents make tlie condition worse. General treatment, espe- cially with bromide of potassium in large doses, has had better effect. DISEASES OF THE VAOINA. 369 Emphysematous Vaginitis (Colpohyperplasia Cystica — Winckel). — Although not very common, this disease is frequent enough to have been observed by a number of gynecologists, and some have treated several cases of it. A prominent gynecologist of this city has told me how puzzled he felt when he was consulted about a case of this kind, as he had not the slightest idea what it was. It is characterized by the presence in the upper part of the vagina and on the vaginal portion of the neck of the womb of numerous translucent, pink, gray, or bluish, soft cysts, varying in size from a millet-seed to a hazelnut. They are situated superficially, and are filled with gas. Some have a central depression. Sometimes they give a crackling sensation like emphysema. When pricked, the gas escapes with a distinct wiieezing sound and the cyst collapses. The disease is most common in pregnancy, but has been found in virgins, but only in women suffering from profuse catarrhal discharge. It does not give rise to any symptoms, except that the introduction of the speculum is painful, and it disappears within three months after cliildbirth. The gas cysts are formed in the lymphatic vessels or the connec- tive tissue, and have, therefore, sometimes an endothelial lining, and in other cases not. The disease is due to a bacillus, which produces gjis and may be cultivated on gelatin. Treatment. — In pregnant women no treatment is needed, since the disease causes no discomfort and disappears after childbirth. In others it has been recommended to ])()ur dilute hydrochloric acid (1 per cent.) through a I\'rgusson speculum on the atfected parts, or use injections of solutions of boric or carbolic acid, or corrosive sublimate. Mycotic, Va(jinitu. — Two kinds of fungi may grow in the vagina — namely, Leptothrix vaf/inalis and O'idium albicans. I^eptothrix consists of fine threads with oval spores. Oi'dium lias hair-like branches. It is pr()bal)ly the same fungus as tiie one forming tlirush in the mouth. Syiiipfonis. — Leptothrix iiardly gives rise to any discomfort. Oi'dium causes sometimes intense pruritus, a burning sensation, swelling, discharge, and even fever. The disease may end in a few days, but may also last several weeks or months, especially in ])reg- naut women. The mucous membrane of the vagina is red, teiidef, and studded with small white spots, which cau only b(> removed together with the ej)ilheliiuii, atid luider the microscope prove to be composed of hy|)iia' and sj)ores. FJinlof/y. — Vaginitis and j)reguancy predispose to the developnxiit of fungi. These mav be directly brought in during coition with men affected with (Iial)et<'s, a disease which fre(|uently is accompanied bv the presence of finigi between the prepuce and the glaml. 'fli(\ ni:iv 21 370 insEAsr':s of women. also be carried on fingers that have handled flour — e. g those of mil- lers or bakei"s. Proqiiosis. — The prognosis is good, and the disease can be cured in a fortnight. Treatment. — Frequent vaginal injections with sulphate of copper (1-2 per cent.), salicylic acid (1-2 per thousand), carbolic acid (3 per cent.), creolin (1 per cent.), or corrosive sublimate (1-2 per thousand). The last-named substance should not be used in pregnant women, on account of the danger of absorption (p. 217). The same solutions may be used for swabbing the vagina through a speculum. Warm sitz-baths, with addition of a little soda or borax, or injections with flaxseed tea and similar emollient substances, are particularly indi- cated in the beginning, if the inflammation is more acute. B. Exudative Vaginitis. — A fibrinous exudation takes place on the surface or in the mucous membrane of the vagina. It makes its first appearance as discrete spots not larger than millet-seeds, but soon these spots extend in all directions and melt together, so as to form one or more large, thick patches. The parts surrounding the patches are more or less swollen, dark red, brown, or dirty greenish.^ It is not settled whether this condition is always identical with the process that takes place in the throat in the disease called dijih- theria or not. The Klebs-Loffler bacillus has, however, been found in the vaginal exudate.^ Etiology. — It is the most common form of puerperal infection. It appears also in severe general diseases, such as typhus, small-pox, and measles. Gonorrhea rarely gives rise to it. Local irritants, such as too strong injections of bichloride of mercury, may cause it.^ Prognosis. — When due to local irritation exudative vaginitis is of slight importance; when symptom of a general disease, it is a sign of serious systemic disturbance; and when caused by local infection during childbirth or in tiie puerperium, there is imminent danger of general infection, wiiicli may end in death. Treatment. — If the condition is due to local irritants, they must, as far as possible, be removed and mild healing substances, such as vase- line, glycerate of tannin, a weak solution of borax, used for applica- tion or injection. If it appears as result of local infection, an entirely different course should be followed. In my experience the best practice is to use cauterization with chloride of zinc dissolved in equal parts of dis- * For further detnils see Garrigues, "Puerperal Diphtheria," Tram. Amer. Gijn. Son., 1885, vol. x. p. 9(j. 2 B. C. Hirst, T>'xtbo.>l: of Obstetrics, Philadelphia, 1898, p. 717. •* Garrigiies, " Corrosive Sublimate and Creolin in ( )bstetric Practice," Amer. .[our. Med. Sci, 1889, vol. xcviii. p. 115. DISEASES OF THE VAGINA. 371 tilled water. Others use pure carbolic acid, Monsel's solution of sub- sulphate of iron mixed with glycerin, tincture of iodine, iodoform, etc. When it is a part of a general systemic infection, the preparations of iodine and iron may be used locally in connection with general tonic treatment. Dysenteric Vaginitis. — This is a variety of exudative vaginitis, sometimes found in patients suffering from chronic dysentery, and who have a gai)iug vulva, through which the dysenteric proce&s extends into the lower part of the vagina. Small gray membranes, com}X)sed of loosened epithelium, and superficial ulcers surrounded by a dark area with overfilled blood-vessels, form on the mucous membrane. In and under the epithelium are found layers of micro- cocci. Treatment. — Besides treating the affection of the intestine — es]^)e- cially by regulation of diet, astringent medicines, injection with a teaspoonful of subnitrate of bisnuith in a cui)ful of boiled starch, or even cauterization with nitric acid — the vagina must be treated as stated above. C Phlegmonous Vaginitis. — Phlegmonous vaginitis is the inflam- mation of the connective tissue surrounding the vagina. 1. One form of this, and the most characteristic, is that known as di«,Hecting vaginitis, in mIhcIi the whole vagina, with the vaginal por- tion of the uterus, is loosened by suppuration from the neighboring tissue and expelled in one mass. Only a few cases of this aflection have been reported. They appeared in the course of severe feverish diseases, such as typhoid fever, ])neumonia, perhaps gonorrhea, and the affection in all came on imnicdiately after menstruation. Symptoms. — The ])atieiit coiiijjlains of more or less intense pain. There is a sanious discharge. 'J'he lai)ia majora are swollen and the seat of superficial ulceration. The mucous membrane of the vagina is swollen, pale, or necrotic. After the expulsion of the vagina the surface heals by graiHilati(»n, and considerai)le stenosis is liable to follow. Treatment. — A tampon soaked in camj)hor emulsion — H. Cani|)liora\ 5ss; Mucilag. acacise, .SJ ; A(pne, ,5iv. M.— Sig. Shake well- should be ke|)t in the vagina until all necrosed tissue is se|)aratod. The s(!j)aration should be aidecl In* cautious pidling and cutting of rasistant siiicwv strings. After expulsion the surface should l)c dusted with {(xloforin or smeared with iodoform ointment, and stenosis should be guard(Kl against by the use of tampons and the frequent introduction of a sj)cculum. 372 DISEASES OF WOMEN. 2. Another form of phlegmonous vaginitis is caused by the burrow- ing of pm from a pelvic abscesfi. For a time a fluctuating swelling is felt somewhere on the wall of the vagina, and later this opens into the vagina or the rectum. Often fistulous tracts remain for a long time, and the suppuration may finally exhaust the patient's strength and lead to her death. Treaimcnt. — An abscess of the latter kind should be freely opened from the vagina as soon as felt. The cavity should be injected with antiseptic fluids and loosely packed with iodoform gauze. Later it may be necessary to dilate fistulous tracts with laminaria or the knife. Vulvo-vaginitis in Children. — The vagina and vulva are not infre- quently inflamed in infants and children. The inflammation may be catarrhal or gonorrheal. The catarrhal form is produced by uncleanliness, foreign bodies, pinworms, masturbation, enuresis, hyper- acid urine, or eruptive fevers. The gonorrheal is due to the pres- ence of the gonococcus. There seems also to be an infectious, non- gonorrheal form.^ The treatment should consist in cleanliness, antacids given inter- nally, and injections of a quart of 1 : 3000 solution of permanganate of potash, made with a soft-rubber catheter and repeated three times a day. This leads to a cure in from twelve to fifteen days. CHAPTER VIII. Gangrene of the Vagina. Etiology. — Gangrene of the vagina may be caused by the presence of foreign bodies — e. g. pessaries, or the contact with caustics — e. g. a tampon soaked in undiluted liquor ferri chloridi (p. 184). It may be due to pressure of the head of the child if, in cases of mechanical disproportion between it and the pelvic canal, impaction is allowed to take place. The most common locality of this occurrence is the upper part of the anterior wall of the vagina, which is caught between the head of the child and the symphysis pubis. The separation of the necrosed plug leads to the formation of a vesico-vaginal fistula. Gangrene of the vagina, like that of the vulva, may appear in conjunction with noma, and is then, perhaps, due to direct trans- mission of toxic material from the cheek to the genitals. It may also be brought about l>y diphtheritic vaginitis (p. 370). Morbid Anatomy. — The whole mucous membrane, inclusive of that ' Aristides Agramoiite, M':(i. Record, Jan. 11, 1896. DISEASES OF THE VAGINA. 373 covering the vaginal portion of the uterus, may be changed to a black, pulpy malodorous mass, and the destruction may extend more or le&s into the depth of the underlying tissue. Symptoms. — Gangrene is accompanied by pain, dysuria, inability to walk, and sometimes hemorrhage, which may even become fatal. Fever is not always present. Treatment. — The vagina should be injected with solutions of car- bolic acid, creolin, or acetate of alumina (1 per cent.), and a tam}>on with the above-mentioned camphor emulsion (p. 371) or a saturated solution of chlorate of pota.sh left in it. Dead tissue should be removed as soon as feasible. The grranulatino; surface should be dusted with iodoform or smeared with iodoform ointment, and care taken to obviate stenosis (pp. 349, 350). The general treatment con- sists in a liberal use of stimulants, tonics, and a nourishing diet. CHAPTER IX. Erysipelas of the Vagina. In a patient who died of general erysipelas the affection had spread to the vagina. The entire mucous meml)rane was red, swollen, wrin- kled, and studded with vesicles, and in some places the epithelium had been thrown off. Treatment. — If the erysipelatous inflammation is discovered in time, the vagina should be cleaned with creolin injections and smeared with ^9-naphtol vaseline (gr. xxv-5J), in conjunction with the general treatment of erysipelas. CHAPTER X. ClCATRICE-S. The vagina is often the seat of cicatricial tiasue, resulting from inflammation, ulceration, or gangrene.' Etiology. — The most common cause is a laceration and sloughing occurring in childbirth. Cicsitrices may also be formed by the use of caustics — e. <). chloride of zinc for dij)lithcritic ulcers (j). 370). Unsuccessful plastic o|)erations, where large surfaces heal by granula- tions, leave also large seal's. Symptoms. — The pres<'nce of such cicatricial tissue may give rise to ' A valuable t)aj)er on this subject by Skene, witli important remarks by T. A. Emmet, is found in Tran.i. Amer. Gyn., 187(), vol. i. p. 91, et scq. 374 DISEASES OF WOMEN. pain, which, although the lesion is permanent, may be intermittent or remittent. This })ain is probably due to irritation of fine nervous fibrillse enclosed in the scjir. By reflex action neighboring organs often l>ecome painful, so that the patient suffers from dysuria and dyschezia; but reflex neuroses may also appear in remote parts of the body — e. g. in the pit of the stomach, under the left breast, etc. Cicatricial bands extending between the walls of tlie vagina or be- tween them and the vaginal portion of the uterus, or ring-shaped contraction of the vagina, may cause dyspareunia, and, when the constriction is considerable, even dysmenorrhea. The condition may end in complete atresia with all its consequences. The cicatricial band may frustrate the use of vaginal pessaries, and place serious obstacles in the way of success in operating for vaginal fistulffi. The scar tissue is harder, less elastic, of lighter color than the normal vaginal wall, and has a smooth surface. During pregnancy it softens very much, so that even extensive scars need not give trouble in a subsequent childbirth. Treatment. — As })rophylaxis care should be taken, in employing caustics, not to use them on larger surfaces nor to a greater depth than is absolutely necessary. To prevent the formation of these cicatricial bands after childbirth by the use of sutures is hardly feasible, since they are formed on bruised and sloughing tissues which could not be united in that way. Sometimes a judicious use of tampons or dila- tors during the healing of a suppurating surface may, however, limit the evil considerably. The curative treatment has recourse to three methods — incision, excision, and insertion of flaps of healthy tissue. A projecting thin band may simply be severed. If the cicatrice is imbedded in the tissue like a cord and is not too extensive, it may be cut out, and the edges united with sutures. If it is very long, it is divided into sections; the edges of wiiich are separated half an inch or more if possible, and healthy tissue brought in between from each side to fill the gap, where it is secured by inter- rupted sutures. If the cicatricial surface is spread out and superficial, it is to be snipped through with the points of a pair of scissors at regular inter- vals. Another parallel column of incisions .is formed in the same manner, but in such a way that the cuts are placed opposite the spaces between two and two incisions in the first column. Thus the whole surface is gone over and kept on the stretch during the heal- ing process by means of a glass plug (p. 350), or better by Boze- man's vaginal dilators, consisting of cylinders of hard rubber with rounded ends and attachment for a string. Othei's recommend slip- pery-elm bark made into a roll and beaten till it is soft. Before DISEASES OF THE VAGINA. 375 introtluction it is dipped in carbolizal water (I per cent.). It swells slowly and promotes healiu<r. CHAPTER XL Vaginismus. Vaginismus consists in a painful tetanic contraction of one or more muscles surrounding the vagina. According to its seat it may be divided into two species — superficial and deep vaginismus. The superficial has its seat at the entrance of the vagina (see p. 43), probably in the bulbo-cavernosus muscle. The deep is a spasm of the levator ani muscle. The superficial is commonly found in women with an intact hymen, the disease itself preventing sexual connection, but may even be developed in women who have borne children. Etiology. — Nearly always some palpable local disease is found in the genitals or the neighboring organs, such as an inflamed hymen, irritable caruncuhe myrtiformes, fissures of the fourchette or vaginal entrance, a neuroma of the fossa navicularis, a urethral caruncle, a fissure of the neck of the bladder or of the anus, vulvitis, vaginitis, a granular os uteri, endometritis, displacement of the uterus, or pelvic inHamraation. An unusually large male member or awkwardness in its use may bring about some of the above-named conditions, and thus be the cause of the disease, but more frequently the underlying fault is a nervous disposition and fear of ])ain in the female. Lead-poison- ing is also said to produce vaginismus. HymptomH. — In superficial vaginismus it is not only the attempt at coition that brings on a spasm of the muscles surrounding the vagi- nal entrance, and thus prevents the introduction of the penis, but the spasm is observed when the physician tries to make a digital examina- tion or introduce a speculum ; even the slightest touch with a feather or a camel's-hair brush or the introduction of a catheter into the urethra may suffice to bring about the tetanic contraction. Sometimes the sphincter ani muscle may enter into a similar condition, or even general convulsions of the whoh; body be added. I have seen opis- thotonos arise which would have suiliced to throw any man aside. Deep raf/iiiismn.'<, alsoealled peiii-s cftpfirus, is a much rarer alfeetion, consisting in a similar s|)asm in the (lej)th of the vagina. It occurs during coition or during a digital examination. Xodifliculty is exj)e- rienced at the vaginal entraiu^e, but in the depth of the tul)(> a resist- ance is met with in the shap<' of a tetanically contracted circular band, which prevents further progress. Jf the spasm occurs after full intro- 376 DISEASES OF WOMEN. duetiou of the penis, the corona is encircled, and the attempts to withdraw the penis cause great pain to both participants in tlie act. Prognoms. — If neglected, vaginismus is a source of great physical and mental misery; if pro})erly treated a cure may always be effected. Treatment. — If one of the above-named causes is found, it nmst first of all be removed. Fissures of the hymen, vaginal entrance, or anus are best treated with })ledgets soaked in a 4 jier cent, solution of chloral hydrate. Others recommend ointments with opium, bella- donna, or other narcotics. Neuromata, urethral caruncles, and car- unculoe myrtiformes are snipped off with curved scissors. A fissure of the neck of the bladder is treated with overdistension, cocaine bougies left to melt in the urethra — I^. Cocainaj hydrochlorat., gr. xij ; Ol. theobromatis, q. s. M. Ft. bacilli, No. xii, Sig. One morning and evening — and application of a strong solution of nitrate of silver. In regard to the other aifections named, the reader is referred to the chapters in which they are discussed. Much benefit may be derived from the use of warm hip-baths, sup- positories with iodoform (gr. v), atropine ointment (gr. ij to 5j), and the application twice a week of a solution of nitrate of silver (gr. x or XX to 5j) to the vulva and hymen, followed by cold, and later lukewarm, applications. The galvanic current, with the soothing positive pole on the aifected parts, has given good results. The general treatment is of the very greatest importance, and its aim must be to brace the patient up physically and morally. If feas- ible, she should be separated for a time from her husband, and, at all events, all attempts at sexual intercourse must be strictly forbidden. She should have pleasant surroundings, cheerful company, and much exercise in the open air, preferably on horseback. She should take a regular course of gymnastics tending toward muscular development of other parts and control over the nerves. Hydrotherajiv and bicycling are also very useful in drawing away the abnormally con- centrated sensibility from the genitals. If these two lines of treatment, removal of the cause and general tonic treatment, do not lead to a cure, sharper local treatment is re- quired. The patient is anesthetized and the vaginal entrance forcibly distended with two fingers or a pluri valve speculum. As after-treat- ment a vaginal glass plug (p. 350) is used morning and evening for a couple of hours. Sometimes the removal of a fleshy, resistant, hyperesthetic hymen by means of a pair of curved scissors will promptly lead to a com- DISEASES OF THE VAGINA. 377 plete recovery. In other cases it is necessary to follow this operation up with incision of the vaginal entrance. The simplest way of doing this is to insert a Sims speculum under the pubic arch, put a finger into the rectum, press the sphincter ani up against the posterior vaginal wall, and divide with scissore on each side of the median line the fibers encircling the vaginal entrance, leaving a space of three-quarters of an inch between the two incisions (T. A. Emmet). Another mode of incision is to imitate the tear in the median ?ine through the {jerineal body that often takes place in childbirth (T. G. Thomas). The deep vaginismus is treated by attention to the cause, especially a granular os, by the general treatment as recommended for the superficial form ; and to overcome the spasm that keeps the penis captive the introduction of a finger into the rectum has been recom- mended. All attempts at violent separation must be desisted from. The captive has to remain imprisoned until tlie subsidence of the spasm or of the erection allows an easy withdrawal. If ether is available, the mere administration of it would probably end the spasm, even before anesthesia is produced. 378 DISEASES OF WOMEN. CHAPTER XII. Neoplasms. 1. Cysts} — Cysts are rather frequently found in the vagina. As a rule, the patients are adults, but congenital cysts have been seen in the vagina of new-born children. Commonly these cysts are single, but occasionally two or more are found in the same individual. They are most frequently situated on the anterior wall. They are globular or oblong, mostly sessile, but may become pedunculated and hang out from the vulva. They grow very slowly, and have often been observed for many years. They vary in size from that of a pigeon's e^g to that of a goose egg, but may exceptionally reach the size of the fetal head at term. The wall varies in thickness from half a millimeter (J^ inch) to a centimeter (|- inch). It is composed of connective tissue, and some- times muscle-fibers. The inside may be lined with simple or ciliated columnar or with flat epithelium, or be Avithout epithelium. The contents may also vary very much. They may be serous or purulent, citrine, yellow^, or chocolate-colored. Sometimes they do not contain form-elements ; in other cases wc find blood-corpuscles, pus-corpuscles, oil-globules, granular cells, epithelial cells, or choles- terin crystals. As a rule, the mucous membrane covering the cyst is freely mov- able and normal, but sometimes it becomes atrophic. The cysts may burst spontaneously with or without suppuration, or be ruptured by injury, especially childbirth. The contents may be discharged into the vagina, the bladder, the urethra, or tli rough the perineum. Vaginal cysts may have very different origins. They may be formed by condensation of the perivaginal connective tissue round an extravasation of blood. They may be retention cysts, due to closure of the outlet of the glands of the mucous membrane which some observers have found (p. 44). Some have been explained as dilated lymphatics. Another theory is that some are developments of part of one of the Miillerian ducts which has failed to unite with its fellow in the formation of the vagina. Some are most likely formed in Gartner's canal, and may then communicate with a par- ovarian cyst.^ Perhaps some are developed from periurethral glands. Symptoms. — If these cysts are small they may not give rise to any symptoms, and are discovered accidentally during delivery or gyne- ^ An exhaustive paper on the subject bv Dr. G. W. Johnston of Washington, D. C, can be found in Arner. Journ. Ohat., 1887, vol. xx. p. 1121. ^ Garrigues's report on a cyst extirpated by Dr. K. Watts, Amer. Jour. ObM., 1881, p. 849, and a note on Gartner's canals in Xew York Med. Jour., March 31, 1883, vol. xxxvii. p. 348. DISEASES OF THE VAGINA. 379 cological examination instituted for other purposes. If they are of considerable size, they cause dyspareunia and a bearing-down sensation. They may also cause leucorrhea, dysuria, and dyschezia. Sometimes they are fluctuating. Prognosis. — ]Many of them give no trouble ; they grow slowly or become stationary ; if necessary they can easily be removed. Diagnosis. — Cystocele may resemble a cyst very much, but the swelling disappears when a catheter is introduced into the bladder. In emphysematous vaginitis there is a large number of small cysts in tlie fornix, and on being punctured they are found to contain gas. Cysts of the vagina are single or few in number, of larger size and filled with a fluid. From solid growths they differ by their fluctuation or elasticity, or by yielding fluid when exploratory puncture is resorted to. Hydatids of the pelvis are filled with a clear, colorless fluid without albumin, containing the characteristic booklets, or perhaps a piece of cuticula with its pathognomonic parallel structureless layers. Treatment. — The best way is to extirpate them and unite the edges by suture. But their relation to the bladder may be so intimate that we would risk cutting into that viscus. Under such circumstances partial excision of the wall is preferable. Tlie most prominent point is seized with tenaculum-forceps or a volsella and the anterior wall of the cyst cut off' with the cover- ing mucous membrane of the vagina, leaving the bottom of the cyst undisturbed. In order to arrest hemorrhage and avoid sup- puration the edges of the mucous membrane may be sutured to those of the cyst (Schroeder's method), the wall of which changes character and becomes like the rest of the vagina. It may also simply be left, and is later exfoliatetl. During this process antiseptic injections should be used. When the vaginal cyst communicates with a parovarian cyst, it is recommended to open the vaginal cyst as far as the base of the broad ligament with the therm o-eautery, and treat the parovarium with iodized injections and a drainage-tube.' 2. Fibroids {Fibroma, Myofibroma, Fibromyomci). — Fibrous tumors of the vagina are rather rare, esix'cially when compared with their frequency in the uterus. Their most common seat is the u|)j>er part of the anterior wall. They are very rarely pure fibroids; that is to say, composed of connective tissue alone. As a rule, this tissue is intermixed with a greater or lesser amount of unstrijied nuiscular fibers. Their starting-point may be in the subnuicous or perivaginal connective tissue or in the muscular coat of the vagina. Sometimes a fibroid in the recto-vaginal partition is in reality a uterine fibroid ' Ainaiid Uouth. VVari.". 0/>.'-7. Soc. London, vol. xxxvi. 380 DISEASES OF WOMEN. that has developed downward, just as, on the other hand, a true vagi- nal fibroid may extend into the vulva. According to the j)redoniinance of the connective or muscular ele- ment, these tumors are harder or softer. Like similar tumors of the uterus, they may undergo a softening by accumulation of serous fluid in the meshwork of their interior. Originally they are globular sessile tumors imbedded in the wall of the vagina, but when their weight increases they have a tendency to become pedunculated, and may then even protrude through the vulva. Such pedunculated tumoi*s are called fibroid vaginal polyjn. Exposed to the air and friction of the clothes, they may begin to ulcerate on the exposed surface. In the lower part of the vagina they often become intimately adherent to the urethra. As a rule, they are single. Etiology. — They may be small as a pea, but they may also become quite large and weigh up to ten pounds. Their growth is a very slow one, and may extend over many years. They are commonly found in adults, but may occur in children. The cause that produces them is unknown. Symptoms. — When small they give rise to no symptoms, and are found accidentally. When they increase in size they cause leucorrhea. When they become still larger and heavier, they cause a dragging sen- sation, dyspareunia, dysuria, dyschezia, and may oppose a very serious obstacle to childbirth. Sometimes they are accompanied by severe hemorrhage. Diagnosis. — When small or middle-sized, they are easy to diagnos- ticate by their elastic hardness. It is true, a thick-walled cyst gives a somewhat similar sensation, but all doubt may be dispelled by means of an aspirator. When they are large enough to fill the vagina, it may be difficult to differentiate them from uterine fibroid polypi. If it is possible to reach the os, this will be found undilated, and no ped- icle passes out through it. From sarcoma a fibroid is distinguished by its slow growth ; it does not undermine the constitution ; and the microscopical structure is entirely different. Prognosis. — The prognosis is favorable. Small fibroids give no trouble. They grow slowly, and if necessary they can be removed by operation. When they suppurate, there is, however, danger of septicemia. Treatment. — A pedunculated fibroid may be removed by tying an elastic ligature around the pedicle, which will be severed in a few days. Or it may be cut at once with an 6craseur or a gal vano- caustic snare, or transfixed with a needle armed with a strong double silk ligature, which is cut in the middle, and the two halves crossed and tied on either side, when they are interlocked like the links of a chain. Lastly the tumor is cut off. Any of these methods prevents hemorrhage. DISEASES OF THE VAGINA. 381 A sessile fibroid is removed by making an incision over its longest diameter and enucleating it. In order to avoid hemorrhage, fingers and blunt instruments should be used as much as possible. The galvano-caustic knife or the thermo-cautery may occasionally be used to advantage when there is much hemorrhage. If the tumor is large, d part of the mucous membrane covering it is included between two .nirved incisions blending at their ends, and the circumscribed piece is left on the tumor. After plain enucleation the edges of the wound are brought together with deep sutures. If a cautery is used, the wound must be packed with iodoform gauze. 3. Mucotts Polypi. — Rarer than the hard fibroid polypi are soft growths of similar shape, in structure like tiie mucous, or glandular, polypi so common in the cervical canal. They give rise to the same symptoms as fibroid polypi. They are verj' vascular, and the safest way to remove them is, therefore, by means of the elastic ligature or by transfixion of the pedicle, as just described. 4. Sarcoma. — This is a rare disease. It appears in two forms — one c/rcuwi.<?cr/6p(^/, forming interstitial globular tumors like fibroids; the other diff'use, extending along the surface like carcinoma. It has been noticed that of the small number of cases recorded comparatively many have occurred in early childhood. In the circumscribed form the development is slower, and may take a couple of years, but, as a rule, the malignancy of the tumor reveals itself by its rapid growth. The prognosis as to a complete cure is very doubtful, as this affec- tion has great tendency to relapse even after complete extirpation. Symptoms. — In adults they are insignificant in the beginning. Later there are leucorrhea, hemorrhage, dysuria, and sensation of pressure. The tumor ulcerates and discharges a sanious fluid. The neighboring organs become implicjited, and the general health is undermined. In children the symptoms referable to pressure on the organs in the pelvis soon iu'coiue pronounced. I)ia(/)tosis. — The diagnosis i'wnn fibroid and carcinoma can only be made by microscopical examination. Treatmcuf. — ('ir(;uniscril)e(l tumors are extirpated like sessile fibroids. The diffiise form may be kept in check foe a time by curetting and cauterization with tliermo- or galvano-cautery, or chlo- ride of zinc as in cancer of the uterus. It might be well to try the application of caleiiim carbid (see Carcinoma Fteri). o. CarcinoiiKt. — Priniari/ carcinoma of the vagina is a rare <lis- ease. As a rule, it is .^('coiithirif, either ])ropagated i)y eonlinuity from neit^hboriiig organs, esj)eeially the cervix ut<'ri, or a])pearingas incfa.^ldtir dej)osits from carcinoma in remote ])arts. Jt is found in two forms, either as a c//vv/y/;.sT/-/7/rr/y>^/yv///rn// growth, and then it is epithelion)atous in structure, or as a (////W.sy careiiioina- 382 DISEASES OF WOMEN. tons infiltration, wliieh ao^ain may have the medullary or scirrhous tyj)e. The difll'use form affects sometimes the shape of a rin^. The cause is doubtless infection with a hitherto unknown microbe. The disease is rarely found l)efore the age of thirty years. Cancerous tumors develop rapidly. The center ulcerates while the periphery spreads over the neighboring tissues. In consequence of the central breaking down, fistulous conmmnications with other canals may be formed, tiie most frequent of which is a recto-vaginal fistula. Tiie lymphatic glands in the ])elvis and at the groin soon swell. The chief symptom.'^ are the sanious, dirty, ill-smelling discharge from the ulcer, hemorrhage and })ain, to Avhich may come the common sym]>toms due to pressure and obstruction, dyspareunia, dysuria, dys- chezia, and dystocia. Diagnosis. — The broad basis, the friable substance, and the hem- orrhage caused by touch are characteristic. The friability, the ulcera- tion, and the hemorrhage serve to distinguish the papillary epithelioma from simple papillomatous vegetations (p. 295). From sarcoma car- cinoma can only be distinguished by means of a microscopical exam- ination. The distinction between primary and secondary carcinoma is of great importance in regard to treatment. Bearing in mind that the vagina is rarely the original seat of carcinoma, we must carefully examine all neighboring organs from which it may have spread, and even other organs from which germs may have been detached and carried to the vagina. Prognosis. — The disease, as a rule, has made so much headway before it comes under treatment that a radical cure is impossible. Even after seemingly complete extirpation relapse is common. The whole body is gradually infected, and the disease soon ends in death. Treatment. — If there is any possibility of operating in healthy tis- sue, the whole tumor should be extirpated and the wound closed by sutures, which will both arrest hemorrhage and bring about union by first intention. In this respect it is advised not even to abstain from excising parts of the bladder and the rectum, the edges having good tendency to unite if properly brought together by sutures. Of late it has even been demanded that under all circumstances the uterus siiould be removed.^ In most cases only a palliative treatment can be attempted, but life may be prolonged and sufferings alleviated by a judicious use of the sharp curette, thermo- or galvano-cautery, chloride of zinc, or bro- mine, applications or injections of chloride of iron, creolin injections, tonics and narcotics, the best of all seems to be calcium carbid, in M-hich respect the reader is referred to the chapter on Carcinoma of the Uterus. 6. Tuberculosis. — Tuberculosis of the vagina is much more common ' ]Vrackenrodt, Centralbl.f. Gyndk., 1896, vol. xx. No. 5, p. 129. DISEASES OF THE VAGINA. 383 than that of the vulva, but is still rather rare. It forms ulcers ou the posterior wall of the vagiua, owing to stagnation of infecting material from the uterus, the disease in the vast majority of cases being only found in connection with tuberculosis of that organ. Miliary nodules, ulcei'S, and caseous masses are visible in the vagina and on the vaginal portion of the uterus, and the microscopical exam- ination shows the presence of bacillus tuberculosis. Tuberculous ulcers easily form fistula? opening into the bladder, the urethra, or the rectum. The tuberculous nature of these fistulse is revealed by the presence of notlules and bacilli around their opening. Such fistulae must be cut out in a wide circumference. Operations for their closure offer scant hope of success. For further information the reader is referred to Avhat has been said about the same affection in the vulva (p. 307). CHAPTER XIII. Fistula. Definition. — A fistula is an abnormal opening leading from the genital canal to the urinary tract or the intestines. In a more limited sense the word is only a])j)lied to such openings the edge of wliich is covered with epithelium, leaving out fresh wounds extending from one canal to the other, or ulcers eating their way through the partition between them. Pathological Anatomy. — According to the nature of the extraneous matter that finds its way through the fistuhe into the genital canal they are divided into uritiari/ and feral fistula?. A. Urinary fi^Htula' are again divided, according to the organs through which the fistula goes, into (1) vesico-vaginal, (2) urethro- var/inal, (3) urefero-var/iiial, (4) ve.sico-uferinc, (5) vesico-utero-vac/inal, (G) uretero-uterine, and (7) nrctero-resiro-vaginal. There may be one or more fistuL'e, and in size they vary from a scarcely percej)tible aperture to an opening measuring two indies in diameter. 1. Vemco-vdffinal Finiula. — The most common urinary fistula is the ve.sico-va(/i)ia( variety. The following descrij)tion applies, therefore, more particularly to it, and the jK'ciiliarities of the i-arer forms will be mentioned later on. J'J(iolof/i/. — liy far the most common cause of fistula is chihlbirih. The mechanism maybe twofold. Tlie abnormal eoinnuniication may be due to a tear, and apj)ear immediately after delivery, or it may be due to pressure with consequent necrosis, and not be developed bcluic several days or even weeks have elaj)s('(l sin<'(> parturition tooU place 384 DISEASES OF WOMEN. Tears are especially found in old primiparje or after the use of ergot or in eases in which the forceps was applied before the cervix was suffi- ciently dilated. Pressure is due to a disproportion between the child and the genital canal, a distended bladder, a loaded rectum, a stone in the bladder, abnormal presentations, etc. In this connection it must be noted that the tissues withstand much better the same degree of jiressure if it is exercised for a shorter time, Fistulee from pressure are, therefore, as a rule, not due to the use of forceps, but to improper delay in their use. As soon as the presenting part becomes impacted and does not move to and fro during and between labor-pains, artificial help ought to be given immediately. In consequence of the im- proved midwifery and the much more frequent use of the forceps fistulfe have become much rarer now than they used to be, and come mostly from remote localities where proper assistance is not avail- able. Fistulse are sometimes due to operations, not only the bungling attempt of the ignorant abortionist, but also in legitimate operations performed by skillful operators. Thus the formation of a vesico- vaginal fistula has been due to vaginal hysterectomy — i. e., the removal of the uterus through the vagina. In rare cases foreign bodies, such as a pessary in the vagina or a stone in the bladder, have gnawed a hole through the partition be- tween the urinary and genital tract. A pelvic abscess opens sometimes in such a way as to give rise to a urinary fistula. Symptoms. — The chief symptom is the more or less constant drib- bling of urine from the vagina, but this does not suffice for a diagno- sis, as the same takes place if the sphincters of the urethra are lost or paralyzed, and, on the other hand, if the urinary fistula is situated high up, the urine may be retained for a long time in the erect pos- ture, and in urethro-vaginal fistula it may be entirely retained except during voluntary micturition. In spite of the utmost cleanliness fistula patients have a disagree- able ammoniacal odor. If tlie fistula is large, it may be felt by digi- tal examination. In most cases it can be seen by introducing a speculum and placing the patient in different positions, especially Sims's, the genu-pectoral, and the dorsal with raised knees (p. 207). Sometimes, however, the opening is so minute that it cannot be discovered, or it may be hidden by a projecting cicatrix. By inject- ing a colored fluid — for instance, milk — into the bladder the presence of a vesico-vaginal fistula may be established. A good way to find a minute opening is to cover with a piece of linen the space within which the opening is supposed to be. Urine will go right through it and make the linen wet (Bozeman). Sometimes the opening cannot DISEASES OF THE VAGINA. 385 be made visible and accessible before intervening cicatricial bands are cut and distended (p. 374). Prognosis. — Small listulse heal sometimes spontaneously, even after a number of years. A later pregnancy has been seen to effect a cure. Until Sims's time most urinary fistulae were, however, practically in- curable. Now, on the contrary, the operations have been brought to such a degree of perfection that very few resist treatment. It is, how- ever, quite frequent that two or more operations are needed before complete succe&s is obtained. AVith proper care the danger of the operation is very small. Treatment. — The remedies at our command are cleanliness, cauter- ization, and closure by means of suture, either at the fistula or at a more or leas remote point. 1. C/eanUness. — A fresh fistula, even of considerable size, may be mucli diminished, and sometimes closed altogether, by giving hot vagi- nal injections and using remedies tliat render the urine normal. As it has a tendency to become alkaline and deposit phosphates, acids are indicated, especially benzoic, boric, nitric, and phosphoric.^ Phosphatic incrustations should be removed mechanically, and the parts lubricated with vaseline or zinc ointment. Raw sur- face are brushed over with a solution of nitrate of silver (gr. x to §j) twice a week. 8itz-baths, once or twice a day, are also very useful. 2. Cauterization. — This method is little used now-a-days, since the perfection of the closure l)y suture. It may, however, be tried for small fistulffi, and is often used successfully, when a small o])ening remains or forms in a stiteh-eanal alter the operation by suturing. The part is rendered insensitive by means of cocaine (p. 223). The galvano- or thermo-eautery may l)e used. Among clienjical caustics, the nitratc-of-silver stick, nitric acid, and carbolic acid an; the best. Tinctun; of caiitharides has also ])rove(l useful. The cauterization ought not to be reoeated until granulations have de- veloped, and do not grow any more. The efiect of the cauteriza- tion is much enhanced by the use of a permanent catheter. 3. ('fo.siire hif Sidnrr <d flic Scat of the Fisfii/a. — This is the most reliabh; and satisfactory of all tlu; methods. \\'e must con- sider sej)arat<'ly the |)re})arat()ry treatment, the operation, and the aller-treatmeiit, all of which are of great importance in effecting a ciu'c. Tlu! best time for operating is six or eight weeks after conrmenient. ' Hc'iizoic acid may he fjivcii in capsiiics ( i;r. x, t. i. d.i. Tlie l)(.'iiznatcs of arniiioniiim, lilliium, or sodiiirii i >;r. v xxxi also foikIit tlit! iiriiK' acid. 1 iiave likewise seen good eliect from the satiitaied solution of l)oric acid, a tai)U'S|»oon- fiil four times a day; S dro[)s of dilute nitric acid four times a day; or Ilorsi'ord's ai-id phosphates, a tcitspoonfn! in a wine;,dass of water, three times a tlay. 25 386 DISEASES OF WOMEN. Jiofore tliat period'spontaneous closure might take ]>lace or cauteriza- tion might suffice for the purpose. The lochial discharge would be luifavorable for healing hy first intention, and the sutures would be more liable to cut through the friable tissue. Later the bladder con- tracts and cicatrices become harder. The preparatoi'y treatment consists in the same measures we have just mentioned under the heading of Cleanliness — namely, hot vagi- nal douches, sitz-baths, acid medicines, removal of incrustations, the use of mild ointments, and painting with astringents. Hairs that are incrustated with urinary deposits are cut off. Cicatricial bands are cut with knife or scissors and the vagina dilated by the introduc- tion of a Bozeman dilator (p. 374). ^\'hen the first incisions are healed, new ones may be made and treated in the same way. By tnis combination of cutting and pressure not only room is gained, which renders the fistula more accessible ; but the cicatricial traction, which is a serious obstacle to agglutination, is done away with. This local preparation may occupy from three to five weeks or longer. Of no less importance is the general preparation. The patient's gen- eral health should be improved as much as circumstances will permit. If the fistula is due to hysterectomy for cancer, it is nt)t worth while trying to close it until sufficient time has elapsed to prove that the sur- rounding tissue is healthy. If the patient has syphilis, that should first be treated. Anemic patients should undergo a preparatory tonic treat- ment. Faults in the digestion should be remedied. Sometimes a sea- voyage or a sojourn in the country may be a great help in building up the debilitated constitution. The operation is performed according to different methods, which may be divided into two groups: the denudation methods and the^or^- splitting methods. To the first belong the methods of Sims, Bozeman, and Simon ; to the latter those of Blasius (Tait), and Walcher. Sims^s Method. — The patient is placed in Sims's position (p. 139), Sims's speculum, or one of the self-holding modifications thereof (p. 150), is introduced. The most dependent part of the circumference of the fistula is seized with a tenaculum, and the edge cut off all around in one stri}) with scissors. In so doing we go close up to the mucous membrane of the bladder without implicating the same, as that causes troublesome and sometimes dangerous hemorrhage. If the denuded surface is not broad enougii, a second strip is cut off from the vaginal mucous membrane outside of and contiguous to the first (p. 357). The edges should be brought together in that direction in wiiich there is least tension. At the angles the denudation is carried far enough away from the fistula to include the folds of mucous mem- brane which will be formed when tiie edges of the fistula are brought in contact. Thus even a very small round hole may necessitate an elliptic denudation half an inch wide and an inch long. DISEASES OF THE VAGINA. ■ 387 Silver wire is used for sutnrino; (pp. 216 and 234). It is pulled through with disinfected silk tlireiid. Round, slightly curved needles made cutting near the point (Fig. 202, d) and 1 inch long are best. If possible, the needle is seized below the eye ; but if the fistula is closed in a transverse line, the needle must be seized at its blunt end and held in the long axis of the needle-holder. The needle should be entered about a quarter of an inch from the edge of the denuded surface, brought deep into the tissue, pushed out just in front of the mucous membrane of tlie bladder, and carried through the corresponding ])oints on the opposite lip. Five sutures are put in for each inch of line of union. As to the use of the coun- ter-pressure hook, twister, suture-shield, and cutting of wires, the reader is referred to the general rules given above (pp. 235, 236). The patient is now turned on her back, the bladder washed out with a double-current catheter, and Sims's relf-retaining, sigmoid, block-tin catheter with many small side o])enings introduced. This catheter should be bent so as to move freely l)ehin(l the pubes as a key turns in a lock. Many now prefer, however, soft-rubber or glass catheters. After-ireatmcni. — The patient should lie on her back, at times stretched out, at others with a round pillow under her knees. A dose of opium is given to relieve pain, and may be repeated several times daily in order to keep tiie bowels constipated for three days. Fig. 241. T?rizciiiaii''- Opcrnliiifr-Tal On the fourth dav the bowels are moved by means of an aj)erient and an olive-oil etiema (.^iv). The sutiu'es are generally removed on the eighth, ninth, or tenth day. The catheter is taken out and cleaned several times a day. A 388 DISEASES OF WOMEN. small flat cup (a bird bathing-tub) is placed under it to catch the urine dripping from it. It is loft in a few days after the removal of the sutures. The patient is allowed to sit up some time during the thii'd week after the operation. Fig. 242. Bozeman's Speculum : a, surface of third blade which is applied to the vasrina; h. a sin rt plate which is pushed under the ends c and d, and thereby kept in place. Bozemari's Method. — Bozeman places the patient in the knee-elbow position, in which she is retained by a special apparatus of his (Fig. 241). His speculum (Fig. 242), which allows one to operate with less assistance and throws light into every part of the vagina, is introduced. The denudation is made perpendicularly, or so as to form a steep funnel, and comprises occasionally the mucous membrane of the blad- der. He cuts with knife or scissors. He uses silver wires, but he secures them by means of his button ; that is, a small concave i)late of thin lead (Fig. 243) with a hole for each suture. The concave side is pressed against the wound, a perforated shot is pushed down over the two ends of each suture, and crushed with a forceps so as to serve as a clamp. The wires are cut at a short distance from the shot and turned down over its sides. Bozeman uses permanent catheterization, and removes the sutures on the seventh day. SUnoti^s Method. — The patient is placed in the dorsal position, with raised pelvis and the legs drawn up — so-called hreech-back position, be- cause the breech presents as in deliveries with breech presentation. Fig. 243. Bozeman's Button. DISEASES OF THE VAGINA. 389 Large broad specula and retractors are used, according to circum- stances, on the anterior, posterior, and lateral walls. The vaginal portion of the uterus is seized with a volsella and pulled down to the entrance of the vagina, where a couple of strong threads are drawn through it and used to pull on instead of the volsella. The edges are cut off with a knife perpendicularly or in a slightly slanting direction. The incision goes through the mucous membrane of the bladder. Fine silk is used for the sutures. These are of two kinds, deep relaxing sutures and superficial liulting sutures, which alternate with each other. From eight to ten are inserted for each inch of union. No catheter is left in the bladder. The patient may urinate herself if she can. Otherwise the urine is drawn with catheter every four hours. The bowels are kept loose. The patient may lie in what position she prefei-s, and eat every thing she likes. If easily accessi- ble, the sutures are removed on the fourth or fifth day ; in difficult cases they are left till the sixth or seventh day. On the eighth day the patient is allowed to get up. The Supr'apubic Method. — For fistulfe that cannot be reached in any other way Trendelenburg makes a transverse incision just above the symphysis ])ubis, through the abdominal wall. Next he makes a transverse incision in the bladder, if necessary all across. Then he denudes the edges of the fistula and inserts silk sutures, which he ties in the vagina, or catgut sutures, which he ties in the bladder. Blasius's Method. — Tiiis is a flap-splitting operation which has been revived by Lawson Tait and othei-s. Nothing is cut away. There is merely made an incision parallel to the vaginal and vesical mucous membrane. This incision is made on the white line of cica- trice at tlie edge to the de])th of from one-eighth to three-eighths of an inch, according to the thickness of the septum. If the fistula is small, it is surrounded by a suture like the string of a tobaceo-jwueh in the following way : a curved and eyed handled needle is introduced through the mucous membrane of the vagina a quarter of an inch out- side of the lower end of the incision, and made to travel in the thick- ness of the vesico-vaginal septinn in a curved direction, following the curve of the se])arati()n of the flaps till it comes to the opposite ])()le of the diameter of tlu! fistulous ojx'ning, and then the |)oint ol' the needle is made again to emerge into the vagina. I'he needle is now threaded and withdrawn, one-half of the fistula being thus embraced by the suture. TIh' needh; is again made to j)ass similarly round the oppo- site half of the fistula, the points of ingress and egress being identical with thos(! of the first halt" of the proceeding. The needle is again threaded and with(b'awn, and in this way the cireiUHvention of the fistida is eonipleted. When the thread or wire is drawn tight and s(!cured,it will l)e found that the flaj) of vaginal nuieons membrane is made to front into the vagina, and that of the vesical mueons mem- 300 DISEASES OF WOMEN. Fig. 244. brane to front correspoiulingly into the bladder, whilst the raw sur- faces between them are brought I'ully together. If the fistula is so large that it is advisable to close it in a linear direction, the needle is made to enter the raw surface of the vaginal flap at the line of incision, burying it deeply in the tissue of the sej)- tuni just beyond the point of division of the limbs of the V formed by the incision, and bringing it out on the corresponding point of the posterior limb of tlie same V. The needle is then threaded and with- drawn. Next, the needle is pushed in the same way through the two limbs of the V on the other side — /. e. the anterior and posterior flap; it is threaded with the distant end of the first thread and pulled back. When such threads, in sufficient number, are placed parallel to one another, the sutures are closed. Tait uses always silver wire. He says it is generally much easier to insert the sutures by means of the forefinger guiding the needle without any speculum than with the assistance of the latter instrument.' Walcher's Method (Fig. 244). — All cicatricial tissue is cut away, sparing as much as possible all healthy mucous membrane. When the cica- tricial tissue is thoroughly removed the edges of the fistula acquire an astonishing mobility, and can be ap- plied to one another without tension. On the place most remote from the field of operation, on the side turned toward the bladder, he makes a sujier- ficial incision around the cicatricial edge of the fistula. Next he makes a similar incision around the cicatrix in the vagina, and then he cuts out the M'hole cicatrix as deep as possible. In some places larger cicatricial masses have to be removed ; in others, where healing had taken place by first inten- tion, the edge is simply s})lit into an anterior and posterior flap. As long as there are immovable parts or ])arts moved with difficulty, the cicatricial tissue has to be removed or cut through. Finally, the wall of the bladder be- comes so movable that in many cases • it can be pulled out through the wound like a loose sac. Now the vesical flaps are brought together in a line by a row of catgut sutures. He introduces the needle on the raw ' L. Tait, The British Gynecological Journal, Nov., 1887, Part xi. p. 368. Walchor's Fistula ()i)o ration : a, fistula ; b, bladder; c, vaginal wall rolled out. DISEASES OF THE VAGINA. 391 surface a quarter of an inch from the fistula, and pushes it out on the line of demarkation between the raw surface and the raucous raera- brane of the bladder, just comprising the latter in the suture (compare submucous sutures, p. 338). Next, the needle is carried through the corresponding points on the other side. When all the sutures are in place they are tied. After thus closing the bladder the vaginal flaps are united in a line above the other by means of silk sutures. The Abdominal Method. — Vesico- vaginal fistulae so situated that it is impossible to reach them from the vagina have been operated on by performing laparotomy and separating the bladder from the uterus and the vagina. Dangers and Difficulties. — With ordinary care there is not much danger of se])sis. In operations near the fornix the peritoneal cavity may be opened — an accident wliieh used to be much dreaded, but now has lost most of its importance. Primary hemorrhage may be quite considerable. Often it may be arrested by injecting hot or ice-cold water into the bladder and the vagina, or by temporary pressure, but sometimes it may become necessary to ligate an artery. This may be done by inserting a silver wire through tiie vaginal wall so as to embrace the bleetling vessel, which experience has siiown usually comes from the neck of the bladder or the neck of the womb (T. A. Emmet). Secondary hemorrhage is vei'v rare. Bloo<lclots in the bladder should be broken uji with a catheter. Hot and ice-cold injections should be made. If these measures do not check the hemorrhage, the sutures must be removed and tiie bleeding vessel looked i'or and tied. One of the greatest dangers in fistula operations is that of injuring or ligating the ureters. The first accident may lead to the formation of a uretero-vaginal fistula more diiHeult to heal than the original vesico- vaginal fistula. The ligation of a ureter leads to acute hydro- nephrosis with high fever an<l vomiting. \{' the field of oi)eration extends more than half an inch from the median line, the ()[)erator should look out for tlie ui-eter. Sometimes it can be seen at the edge of the fistula. Then tiie ureter must first be s})lit open from the bladder to the extent (»f half an inch and the edges of the wound allowed to heal separately, so as to throw the mouth of the ureter further back into the bladder before y\\v. fistula is closed. The operator should note the mimber of sutures he introduces and be sure to remove them all, as an overlooked or eut-olf suture may form the nucleus of a calculus in the bladder. When there is (ir<(d /o.v.v of suhsldiwe it is often impossible to unite the edges on one line. It may tlu-n become necessary to give to the line of union the shape of a Y, a T, or an I. In large- (istuhe it is also sometimes found advantageous not to 392 DISEASES OF WOMEN. denude the whole edge at once, but to operate in sections, paring and uniting one part before the next is taken hold of. In this way much blood may be saved and the field kept clean. Long tine fistulse in front of the cervix have been closed by fresh- ening the surface with a dentist's engine, substituting cutting edges for the blunt ones, and approximating the vivified walls with deep sutures.^ If the fistula is situated near the bone, the fiap-splitting operations may hold out the best prospects for effecting a cure. Before removing the sutures it may be well to try if the fistula is closed by injecting a little milk into the bladder. If the edges and stitches loolc; healthy and there is a leakage, complete closure may be obtained by leaving the sutures in for a day or two longer. Combination of Methods. — By a judicious combination of the best features of the operations described above an operator may obtain better results than by adhering tenaciously to the rules laid down by one of the inventors of methods. Preparatory cutting and stretching of cicatrices are of great importance. Bozenian's or Simou's position give sometimes better access to the fistula than Sims's. It is often impos- sible to pull the fistula down so as to operate near the vaginal entrance, as prescribed by Simon. The dislocation of the uterus may give rise to pelvic hemorrhage or inflammation. It is, therefore, better to ope- rate in situ, and for this silver wire is mucii preferable to any other material. The largest specidum that finds room should be used, but, as a rule, the larger the fistula the smaller the speculum must be. The per- manent catheter is liable to cause cystitis, which again interferes with healing by first intention. It is also very uncomfortable for the patient to lie constantly on her back. The introduction of a hard catheter has sometimes mechanically interfered witii healing. If the bladder has retained a reasonable degree of capacity, it is better to let the patient urinate or draw the urine with a velvet-eye, soft rubber catheter. But in large fistulse with great retraction of the bladder the use of the permanent catheter is preferable. It is a decided advantage to keep the bowels open and let the patient take plenty of substantial food. 2. Urethra-vaginal Fistula. — In this kind, the wall of the septum being very thin, the denudation must be extended over the nearest part of the vagina. The edges are brought together from side to side over a metal catheter, and if the tension is great, an incision is made on both sides parallel to the line of union. Atresia of the upper pari of the urethra may be combined with a vesico-vaginal fistula. Then tli-i closed canal may be perforated with a trocar and kept open by the daily use of sounds. Another method is to cut out the closed portion of the urethra and unite the lower to the neck of the bladder. ^ Thomas, Diseases of Women, 6th ed. p. 274. DISEASES OF THE VAGINA. 393 If the atresia is situated between a urethral and a vesico-vaginal fistula, the impervious portion is bridged over by uniting the upper edge of the vesical fistula with tlie lower of the urethral, or if the loss of substance at the base of the bladder is so great that this can- not be done, or would cause so much tension on the urethra that incontinence would follow, an artificial transverse vesico-vaginal fistula is made just above the neck of the bladder, between the two other fistulse. The upper edge of this artificial fistula is stitched to the lower edge of the urethral fistula, and after healing has taken place, the edges of the original vesico-vaginal fistula are brought together from side to side. The whole urethra may be destroyed and may be restored by bor- rowing tissue from the surrounding mucous membrane (compare p. 273). 3. Uretero-vaginal Fistula. — Remembering the relations between the ureter, the neck of the womb and the fornix of the vagina (p. 84), we can easily imagine how a fistula may be formed between the ureter and the uterus or the ureter and the vagina, but it is fortunate such communications are rare, since they are difficult to cure. A uretero-vaginal fistula is situated on the anterior wall of the vagina, a little below and outside of the vaginal portion of the ute- rus. It is distinguished from a vesico-vaginal fistula by introducing an elastic catheter, which, if tiie fistula is ureteral, can be pushed deep in in the direction of the corresponding kidney, and urine Avill be secreted in jets from it. Milk injected through the urethra will come out immediately through the fistula, if it be vesico-vaginal ; but will not pass through a ureteral fistula. Often that part of the ureter which is situate between the fistula and the bladder becomes obstructed, li' under such circumstances the fistula were closed, acute hydronephnxsis with all its dangers would l)e the result. The perviou.sness of the lower portion of the ureter is made out by introducing one ])rol)e through the fistula and another through the urethra, which will come in contact in the bladder, if there be free communi(;ation between the fistula and that organ. The c(UiseH of uretero-vaginal fistula are pressure during child- birth, the gnawing of a pessary, hysterectomy, or the o])eration for a vesico-vaginal fistula, in <'onse(juence oi' which the ureter may be injured. Treatment. — Three operations are available: closure of the fistula, implantation of the ureter in the bladder, or nephrectomy. A. Chxure of the Fktnla. — The fistula has been directly closed in different ways. a. Baii(I/'s MefJioiJ (Fig. 245). — I'nndl ma<l(> an elliptic incision around the fistula in the course of the ureter, cut out some tissue at the lower end of this inci.sion and made an opening into the bladder, press- 394 DISEASES OF WOMEN. ing it out from behind with a sound. Next he introduced a fine flexible catheter (French No. 2) into the bladder through the urethra, Fig. 245. Diagram of Bandl's Operation for Uretero- vaginal Fistula (the patient is in genu-pectoral pos- ture); SS, vaginal wall; V, line of union after closing a vesico-vaginal fistula in a pre- vious operation, which had led to the formation of the nretero-vaginal fistula ; B, bladder ; U, vaginal poriion of uterus ; H, right ureter ; H', left ureter opening at « into the vagina; cc, first incision ; de, flat denudation in the vagina ; b, artificial opening into the bladder. drew its point with a forceps through the artificial opening made in the bladder, out into the vagina, and ]>ushed it into the ureter. Next he denuded the vagina outside of the first line of incision and brought the raw surfaces together with four silver wire sutures, over the cath- eter. He used Bozenian's position, speculum, and button, and left another catheter in the bladder.^ 6. Pozzi's Method. — Poz/i used the flap-splitting method in a case of uretero- vesico-vaginal fistula. He placed the patient in the knee- chest position, made a ti'ansverse incision extending half an inch beyond the borders of the vesico-vaginal fistula and a perpendicular at each end so as to form an H. Next he dissected the two flaps off to a distance of half an inch, brought them together over the openings of both fistulae with three deep silver-wire sutures and three superficial sutures.^ ' Ludwig Bandl, Die Boznnnnsche Methode der Blasem^dieidenfistel- Operation mid Beilrdge znr Operation der ILtrnleiter- nnd Blnsensc.heidenfiMeln, Wien, 1883, p. 42. ^ Pozzi, Traite de Gynecobgie clinique et operaloire, Paris, 1890, p. 934. DISEASES OF THE VAGINA. 395 B. Implantation of the Ureter in the Bladder ( Uretero-cystostomy). — The abdomen is opened in the median line as in other laparotomies. The ureter is dissected out, and an opening made in the posterior wall of the bladder by (fitting down on a cIoschI forceps introduced througii the urethra. A thin flexible catheter is introduced into the ureter and pulled out through the urethra. The ureter is then fast- ened to the wall of the bladder by means of interrupted silk sutures. A self-retaining soft-rubber catheter is inserted through the urethra into the bladder beside the ureteral catheter ; and finally the abdomen is closed. C. Nephrectomy. (See below, under Uretero-uterinc Fistula.) Of these three operatious the closure of the fistula, as the safest and simplest, should first be tried. The implantation of the ureter in the bladder has given good results in several cases, and should be pre- ferred to the mutilating nephrectomy. 4. Vesico-uterine Fistida. — Fistulous communication between the urinary system and the uterus can only take ])la('e in the cervix. The other end of the fistula may be in tiie bladder or in the ureter, and it is of vital importance to distinguish betweeu these two condi- tions. Common for both is the discharge of urine from the os uteri. The vesico-cervical fistula forms a small round hole opening in the middle of the cervix, a condition which has been brought about by imperfect healing of a tear through the anterior wall of the cervix and the base of the bladder. Diar/nosis. — Sometimes a probe can be brought from the bladder througii the fistula into the cervical canal, where it comes in contact with a uterine sound held there. Milk injected into the bladder will come out of the os uteri. If the cervical canal be j)luggcd with a laminaria tent, no systemic disturbance will result; while, if it is a uretero-cervical fistula, acute hydronephrosis is developed. P/w//!o.s'/.s'. — This kind of fistula has an unusual tendency to spon- taneous healing, which jjrobably is due to the thickness of the wall in which it is situated. Treatment. — This tendency to spontaneous closure mav be furthered by (".uiterization. If that does not succeed, closure by suture may be attcMupted in diflerent ways. a. h'mmct'.s MctJtod. — The anterior lij) of the cervix is sj)lit open in the median line, so as to re|)roduce a condition similar to that obtain- ing when the injiu'v was fresh. In this way the fistula is reached, and pared, and tlu; woutid united by silver-wire sutures from side to side. h. F()let\s Method. — The urethra is dilated so as to admit the index- finger, and the cervix is |)ulled down to the vaginal entrance. A transverse incision is made in front of the cervix, the bladder dis- sected off, and the opening in the bladder closed, the linger in the urethra aidinir the introduction of (he sutures. 396 DISEASES OF WOMEN. It seems that even the somewhat risky dilatation of the urethra (p. 144) may be dispensed with.^ As a last resort the cervix may be turned into the bladder by suturing it to the borders of a hole cut from the vagina into the bladder. 5. Vesico-%itero-vag'mal Fistula. — This fistula goes from the blad- der through the anterior lip of the cervix and ends in the vagina. Treatment. — If there is enough of the anterior lip of the cervix left, it is denuded and stitched together with a correspondingly pared surface on the anterior wall of the vagina. If there is not tissue enough left in front, the ])()sterior lip of the cervix is pared and bi-ought together with the anterior lip of the opening in the bladder. \\\ this procedure the cervix is turned into the bladder, and the menstrual flow is secreted with the urine through the urethra. 6. Uretcro-tdcrine Fistula. — In this variety, as in the vesico-ute- rine, urine flows from the os, but the exact condition can be made out in different ways. INEilk injected into the bladder will not come out through the os. If the cervical canal be plugged, there will soon appear symptoms of acute hydronephrosis, sucli as pain in the lumbar region, vomiting, and fever. The most conclusive test is, however, that of Berard. The bladder is emptied with catheter, and the patient is placed on a vessel that will collect all the urine coming from tiie vagina. At the end of two hours the urine is again drawn from the bladder by means of a catheter. The amount obtained will equal that which has flowed from the vagina, each being the secretion of one ureter. The ureter may perhaps be felt swollen (p. 166). That it should be possible to intnKluce a ureter-catheter into the uterus from the bladder (]). 165) is very unlikely. This variety of fistula is exceedingly rare. Treatment. — The cervix must be turned into the bladder as de- scribed above. As the lower portion of the ureter is usually oblit- erated, it is not allowable simj^ly to close the os uteri, apart from the trouble that might be anticipated by the stagnation of urine in the uterus. Another method more dangerous, but offering the advantage of not interfering with fertility, consists in nephrectomy ; that is, the removal of the corresponding kidney through an incision made in the lumbar region (Simon). 7. Uretero-vesico-var/inal Fistula. — When the ureter has been partly destroyed at the same time as a vesico-vaginal fistula is formed, the opening of the former is found somewhere on the edge of the lat- ter. This condition may be cured in a way similar to a uretoro- vaginal fistula, but in so doing it is sometimes an advantage to ^ A. Benckisser, Centralblatt f. Gyndk., 1893, vol. xvii. p. 847. DISEASES OF THE VAGTNA. 397 make a slit leading from the lumen of the ureter to the interior of the bladder. Genital Cleins. — When it is impossible to close a fistula, relief from the troublesome, constant escape of urine may be afforded by- closing the genital canal below the seat of the fistula, an operation called cleisis, or closure. We have already alluded to the closure of the uterine os (Jiystei'o- cleisis), the turning in of the cervix into the bladder (Jiystcro-cysto- cleisis). The vulva may be made the seat of the closure {episio- cleisis) ; but this is a very objectionable procedure, since it not only, like the two others, renders impregnation im])ossible, but prevents coition, causes stagnation of urine, and may giv(! rise to the forma- tion of stone in the lower part of the vagina. Tiie most common seat of this closure is the vagina (cnlpoclci.si.'i). In performing this operation the operator should always keep in view the desirability of preserving as much of the deptli of the vagina as possible. Closure should therefore not be made at a lower point than neces- sary, and often much can be gained by giving the line of union a slantiug direction. The patient is ])laced in Simon's position (p. 388). A narrow strip is cut off' from the mucous membrane of tiie vagina in such a way that the denuded part of the anterior wall fits to that of tiie posterior. These are now brought together by sutures accordiug to general rules (Fig. 207, p. 234). Diiriug the insertion of sutures on the anterior wall a sound is kept in the bhulder, and while working on the posterior wall the o[)erat()r uses a finger in the rc(!tum as a guide. Through the development of better methods for the direct closure of urinary fistula, the use of genital cleisis has become more and more rare. Still, the operation is occasionally indicated in eases of great loss of substance, when tlun-e is much cicatricial tissue around the fistula ])artly adherent to t\m bone, when the bladder is inverted and filled with ])art ot" the intestine, and especially in certain cases of uretero-uterine and vesico-ntero-vaginal fistula. (See above.) When the urethra had been lost or its lower edge was too Aveak to be pared and stitched, \'on Nussbaum combined cleisis with the formation of an artificial siijird-pnhic iirdlmi. He ]>unctured the bladder above the symj)hysis, and left tiie canula in pl:ic(i for two weeks. Then the patients were allowed to get up, and directed to empty the bladder (;verv two or thi'ce hours with a female! catheter. At the end of a few months the catheter could be dispensed with, the urine i)eing (h-iven out at will, in a jet, by contraction of the abdom- inal muscles. In the interval the recti and pyramidales muscles kept the little opening closed. Urimils. — If for some reason or other no operation can be per- 398 DISEASES OF WOMEN. formed, the patient may derive more or less comfort from the use of a urinal. These may be divided into two classes, the extra- and iutra-vaginal. To the iirst belong rubber bags with a wide opening covering the vulva, and fastened to the pelvis and the thigh. To the second belong tlie ingenious apparatus of Bozeman and Jay. Boze- man's consists in a flat pear-shaped receiver of silver with a number of holes on the side that comes in contact with the anterior vaginal wall. The urine enters through one or more of these holes, and is led through a tube to a rubber bag attached to the thigh. Jay's con- sists in a strong soft-rubber ring, to which is attached a bag of the same material, ending in a tube which is compressed by a siuit-off. The ring is introduced into the vagina where it stays by its own expansion. The patient takes a daily sitz-bath, and slips the nozzle of a syringe into the exit-tube and fills the urinal repeatedly with warm soap-suds.^ I have, however, found that patients, for different reasons, such as pain, excoriations, lack of coaptation, get tired of wearing urinals and prefer to protect themselves with towels. Operations for Incontinence. — It happens sometimes, after a com- plete closure of a fistula, that the patient continues having a con- stant dribbling of urine, which now escapes involuntarily through the urethra. This condition may be due to the loss of the sphincter muscles of the urethra, or to traction being exercised on the urethra, by which it is kept open, or simply to the habit of contraction acquired by the bladder while the fistula was open. Sometimes a spontaneous cure takes place by shrinkage of a cicatrix running across the neck of the bladder; but this is at best slow work. Pawlik^ has devised an operation by which the condition is remedied at once (Fig. 246). The patient is placed in knee-elbow po- sition. The urethra is pulled to one side with a tenaculum as far as })ossible (a). The limits of the fold thus formed are marked on the mucous membrane. From these points two parallel lines are drawn up and made to converge at their u])per end near the subpubic ligament. Next, „ ,., , ^ ° ,. . -, ,. the meatus is pulled as far as possible Pawlik s Operation for Iiiconti- •wv.wi j | ^ x nence: H, urethra; A. denuda- tOWard the clltOriS Without USUlg UUduC tion: o, point .to which the „ t n i • i. t i //\ T^l nrethracan bepuUed toaside; lOrCC, and that pOUlt niarkec] (0). lllC fi.point to which it can be pulled i- „ r>f inoI^iVm nro nnw r'ontinnpfl in n in the direction of the clitoris. llUCS 01 inClSlOU aiC llOW COniHlULU JO a slightly convergent direction to 6. The thus circumscribed tissue is cut out in the shape of a Mcdge, and the ^ John C. Jav, Jr., New York Medical Record, Aufj. 2S, 1886, vol. xxx. p. 251. The urinal is iriade by Parker, Stearns & Sntton, 228 South street. New York. '■^ Pawlik, Wiener Med. Wochem^chriff, 1883, Nos. 25-26, p. 772, and Zeiischrift fur Geburtshiilfe und Gyndk., 1882, vol. viii. p. 38. DISEASES OF THE VAGINA. 399 wound united with deep sutures of sillvAvorm gut and covered with iodo- form. After seven days tlie sutures are removed, and, the wound hav- ing healed by first intention, the other side is treated in the same way. Tlie object of this operation is to stretch the urethra from side to side, and at the same time to bend it in the direction of the chtoris, by which double process its posterior and anterior walls are brought in contact. The same operation may be performed when the urethra is gaping and the patient suifers from incontinence without having had a fistula. Sometimes the cause of incontinence is irritation caused by a band attached to the urethi-a and spreading itself over the anterior aspect of the vulvo-vaginal junction. A cure may then be effected by clip- ping this band. In other cases wings of mucous membrane are found attached to the urethra. The treatment consists in their excision and union of the wound by interrupted sutures. In still other cases the cause of the enuresis seems to be an enlarged meatus. An incision is then made in the sagittal plane on either side of the urethra, and the edges are united at right angles to the incision. The patient should be kept in bed for two or three weeks. The wound is smeared with cold-cream,^ or, better, dusted with stearate of zinc. The patient may then urinate herself. If the incontinence of urine is due to a cysto- cele or urethrocele, Watkins's operation (p. 358) may effect a cure. B. Fecal Fistuke. — A fecal fistula is one leading from the intes- tine to the genital canal. They are much less common than urinary fistulse. Pathological Anatomij. — There may be one or more openings. The fistulous communication may take [)lace between the rectum and the vulva — recto-vidvar or recto-lahial Jvitala ; the rectum and the vagina — recto-vaginal fuitida ; between the ileum or the sigmoid flexure of the colon and the vagina or uterus — entero-vaginal, ilco-vagimd, and ileo- nteriiie jldala. The size differs from that of an opening so fine that it may be very difficult to discover to that of one easily admitting a finger. Often the aperture is larger on the vaginal side than on the intestinal. The seat varies also very much. A fecal fistula may be situated anywhere connecting tlu; intestine and the vagina, but it is most commonly fi)und either immediately al)ove the s|)hin(!ter ani nuiscles or at the fornix. As a rule, it is found on the j)()sterior wall of the genital canal, but the entero-vaginal variety may exci'jjtionally oj)en in front of the uterus. Sometimes the length is almost nil, (he rectal and vaginal walls com- ing in contact in th(! thin s(ij)tum between the two. \n other cases, when the fistula is the result of an abscess, the inner opening may be a.s nnich as three inches and a half up the rectum, while the outer is found on the inside of the labium majus. ' D. Tud (jrilliam of ( 'oIuiiiImis, O., .l»n<T. J<nir. Obd., 189G, vol. xxxiii., Xo. 2, p. 177. 400 DISEASES OF WOMEN. Etiology. — The ciiuses of fecal fistnlse are in many respects like those determining urinary fistnlse. The most common is childhirih, and the fistula may either be due to pressure between the fetal head and some bony prominence in the pelvis or remain as the result of imperfect spontaneous healing of a tear through the perineal body. It may be brought about by ru})ture of tlie vagina or uterus, an intestinal knuckle being caught in the rent and becoming necrotic, or by diphtheritic and gangrenous processes due to puerperal infection. Frequently a fistulous opening remains just above the artificially united perineal body after perineorrhaphy. Rarely hysterectomy has led to the formation of such a fistula at the fornix. Occasionally the fistula is due to a neglected vaginal pessary, that gnaws a hole into the rectum. Abscesses, either pelvic, vulvar, or prerectal, end sometimes with the formation of a fecal fistula. At the fornix it may be due to a sup- purating dermoid cyst or extra-uterine pregnancy ; at the vulva the inflammation begins often in Bartholin's glands. We have mentioned above that direct injury, especially violent coition, may cause a permanent fistula (p. 283) and that the solution of continuity may be due to ulcers — cancerous, tubercular, or syphi- litic — perforating the partition between the two canals. In syphilitic patients the fistula is often found just above a strict- ure of the rectum. Sympto7ns. — The escape of flatus and, Avhen the bowels are loose, thin fecal matter, through the vagina soon attracts the patient's atten- tion. The irritating contact with the excrementitial matter causes catarrhal vulvitis and vaginitis. Of entero-vaginal fistulas there are two varieties with very different symptoms. If the opening is small {ileo-vaf/imd fisfiihi), they do not differ materially from any other fecal fistula, but if the whole circum- ference of the intestine has been destroyed and the edges have coa- lesced with the rent in the vagina [preternatural anus), all the feces find their exit through the vagina. If the affected part, as usual, is the ileum, undigested food mixed with bile will make its appearance at the fistula about two hours after meals, and the patient will lose flesh and finally die from starvation. Her weakness may also cause amenorrhea. I^arge fecal fistula) can be felt, small ones maybe seen, but are often hard to find on account of their diminutive size. Probing and injec- tion with colored fluid may help to find the inner opening. In an entero-vaginal fistula, a whole intestinal knuckle having been destroyed, there may be two ojx'nings with a so-called .npur between them. Prognosis. — Fecal fistula) have in so far a better prognosis than urinary, as a larger number of them heal sjjontaneously ; but, on the DISEASES OF THE VAGINA. 401 other hand, those which have no such tendency, are harder to heal by operation, the reason of which is doubtless that while urine is harmless or can easily be given an exit, the intestine is always full of pathogenic microbes, which it is difficult or impossible to keep away from the wound. Mechanical difficulties are likewise of much importance in jeopardizing closure by first intention. If we induce constipation large fecal masses will accumulate, and their final expul- sion may tear open the already healed fistula. If, on the other hand, we keep the bowels loose, the contraction of the perineal muscles during the act of defecation is liable to cause a fistulous tract to remain just above the sphincter ani muscles. "We have already intimated that in certain forms of fecal fistulse nutrition becomes insufficient. Treatment. — Preventive Treatment. — ]\Iuch can be done to prevent the formation of fecal fistulae by having their etiology in mind. Thus an enema of soap-suds should invariably be given in every labor case before the head enters the pelvic cavity. The pelvis should be carefully examined before labor in regard to narrowness or projecting points, and according to circumstances re- course should be had early to the high-forceps operation, version, craniotomy, or symphysiotomy, or even Cesarean section. Pessaries should always })e kept clean with daily vaginal injec- tions, and removed at least once every two months. If there is any gnawing, the jx'ssary should be left out for a week and carbol- ized injections used until all abrasions or ulcers are healed. It goes without saying that most strenuotis etforts should be made to prevent syphilitic; ulcers from forming fistula\ Perhaps we shall soon have in one of the many remedies now being experimented with a means of checking tuberculous ulcei-s in their destructive progress. Even at the; height of sexual passion men should exercise a reas- onable control over themselves, especially if nature has endowed them with an unusual (l('velo])nu'nt of the part concerned. Pus in the pelvis or near the lower end of the rectum should be given an exit by timely operative interference. Curative Treatment. — A cure may be obtained by cleanliness, the elastic ligature, or cutting operations. A. Since many small ll-cal fistiihe have a decided tendencn' to close of themselves, this liapju' result should l)e facilitiited l)y scruj)ulous eleanHne.HH, especially sitz-i)aths, rectal and vaginal injections, and prevention of eonstijjation, combined with cauterization (p. .'W."}). H. Lif/ature. — In re(!to-lal)iMl fistula, which we have seen often extends far up th(; gut, a cutting operation would be liable; to cause great hemorrliage, and by forming a cloaca leave the patient in a worse condition than sju; was before. This alfeetion is treated suc- wissfiilly by changing it into a conunon fistula in ano, and treating 2''. 402 DISEASES OF WOMEN. that with the elastic ligature.' The usual surgical silver probe, armed with an elastic ligature, is introduced into the labial orifice, pressed down to the perineum just outside of the sphincter ani, where the end is liberated by an incision and the probe withdrawn. A more ductile one is substituted, and passed through the sinus from the labial opening to the rectal 0|>ening, having the eye threaded with the other end of the ligature. The finger introduced into the rectum recognizes the probe, which is then curved and gently drawn through the rectum and anus. The two ends of the ligature are tied, shotted, and clamped (Fig. 247). The labial orifice is left to itself and closes in a few days, Fig. 247. Barton-Taylor's Operation for Recto-labial Fistula: A, anal end of ligature; B, labial fistula; C, incision in jjerineum. The fine dotted lines mark the coiirse of the recto-labial sinus; the heavy dotted lines represent the ligature where it is imbedded in the tissues. or at most two weeks, for just as soon as the rectal opening is united and the ulceration or sinus gradually healing up, there can no longer pass any gas or fluid feces through the sinuous tract and the labial orifice. This treatment is so little painful that the patient need not even be kept in bed. The ligature will cut through in from three to eight days, and if the elastic^ thread ceases its pressure the remnant of * This method orijifinatedwith Rhea Barton of Philadelphia, and was improved by I. E. Tavlor of this City, who, on November 18, ISSo, read a paper on Bedo-labial and ViUvar FUtulce before the New York State Medical Association. DISEASES OF THE VAGINA. 403 embraced tissue is easily severed with scissors or Paquelin's cau- tery. C. Cutting operations may be performed from the perineum, the vagina, or the rectum. I. For a rectal fistula situated low doicn three different suture- operations recommend themselves. 1. Emmefs Method. — Split the perineal body with scissors in the sagittal plane up to the fistula, cut its wall away and unite as for ruptured perineum (p. 340). 2. Tait's flap-splitting method with circular suture (p. 389) is well adapted to these small openings. 3. Fritsch's Flap-sliding Method. — A crescent incision is made on the vaginal wall with the convexity turned down and just touch- ing the upper border of the fistula. A similar incision is made between the ends of the fii"st extending half an inch below the fistula. The enclosed crescent-shaped part of mucous membrane is dissected off. Finally, the flap above the fistula is drawn down so as to cover this denuded surface and the fistula, and fastened all around with sutures^ to the mucous membrane or the skin. Whichever method be used it is best first to paralyze the sphincter ani muscle by overstretcliing it. II. Rectal fi^tulce situated higher up in the vagina are, as a rule, operated on from the vagina in one of three ways : Bureau and Vi- gnard's treble tier-suture, Tait's flap-splitting operation, or colpo- perineorrhaphy. 1. Bureau and Vignard made a vertical incision in the median line, extending half an inch above and below the fistula, dissected the vagina from the rectum to a distance of half an inch from the fistula, form- ing two rectal and two vaginal flaps. The edges of the rectum were united by a continuous suture of chromicized catgut, avoiding to pene- trate into the Interior of the gut. Relaxation sutures were inserted at the angle between the rectal and the vaginal flaps, but not tied. I^ext, the edges of the vaginal flaps were brought together with a continuous suture of chromicized catgut. Finally, the relaxation sutures were tied.^ These fistulaj have strongly l)eveled edges, the vaginal opening being much larger than the rectal. Sometimes the vaginal edges can be brought together after making lateral incisions in the vagina, but cases are occasionally met with in which no extent of division of tissue on the vaginal surface will permit of tlie edges bciuir brought together. In sneli a case it is necessary to split tlie edges of" the fistula on each side to a depth sufficient to permit the c{\'^v> of the rectal wall to be brought to- » IT. Fritsch, CentralblnU f. Gi/vak., 1888, vol. xii. p. 80(5. ' Bureau and Vignard. Ontmlhl. f. Gyniik., 1894, vol. xviii. No. -10, p. 001. 404 DISEASES OF WOMEN. gether below, leaving the vaginal opening to be filled up by gran- ulation.* Denudation in fecal fistulae must be made much larger than in urinary. In the lower part of the vagina the edges are, as a rule, united from side to side. In the upper, when there is much loss of substance, the edges must sometimes be brought together in a trans- veree line. 2. Tail's fiap-spUtting with interrupted suture (p. 390) may be available. 3. German authors recommend a denudation and adaptation from side to side as in co]po-|)('rineorrhaphia for incomplete rupture of the perineum (p. 327). Operation from the Rectum. — In exceptional cases it may be impos- sible to bring the rectal fistula into view on account of a cicatricial band at the outlet of the vagina. As this band works as a substitute for the lost sphincter urethrse by keeping the walls of the urethra in contact (compare ]). 398) it should not be divided. Under such cir- cumstances the operation is performed from the rectal side.^ The intestine should not only be cleaned out by high enemas of water and irrigated wltii an antiseptic solution during the operation (p. 238), but it may even be well to try to combat the germs in the upper part of the intestine by the internal administration of naplitha- linc (gr. ij to viij pro dosi, up to gr. Ixxx in twenty-four hours), salol (gr. X q. two hours), or carbolatc of bismuth (gr. x every two hours). The sutures are ])ut in near the edge on the rectal side, but should go out a quarter of an inch from the edge on the v;igiiial side. Enter o-vaginal Fistulce.^ — If the fistula is only lateral it may be closed by denudation and suture like another fecal fistula. In a case of vaginal anus it must be ascertained if the lower part of the bowel is pervious, as it is evident that no closure must be attempted unless an exit can be given to the fecal matter. Different operations have been performed or proposed for the relief of this kind of fistula. 1. If there is a double opening the s])ur between the two may be cut by introducing Dupuytren's enterolome, or another strong pair of forceps, to the depth of one and a quarter inches, and the edges of the fistula denuded and united by sutures. 2. Laparotomy may be performed, the intestine cut loose from the vagina or uterus, and the ends united by cnterorrhaphy. If the lower end is closed or too narrow, an anastomosis may be effected between the upper end and the large intestine. ' T. A. Emmet's (hinecnlorjy, p. GG2. * Emmet, /. c, p. 6(K;. ^ Tliirty-nine cases have been collected by II. L. Petit, Annales de Gyneeologiey vols, xviii., xix., xx., 1882-83. DISEASES OF THE VAGINA, 405 3. It has also been proposed to loosen the wounded part of the in- testine and insert it in the rectum from the vagina. 4. After having made an artificial rectovaginal fistula, colpocleisis may be performed under it. General Remarhs about the Operation for Fecal Fistulce. — In ope- rations from the vagina or the perineum Simon's position (p. 388) should be used. It is often a help to introduce a small Sims specu- lum under the symphysis pubis and lateral retractors on the sides of the vagina. In operations from the rectum Sims's position or the genupectoral should be used. Silver-wire sutures are preferable. If used in the rectum they should be turned down toward the anus, so as not to offer any resist- ance to the exit of the feces. They may be left in two weeks, while silk must be removed at the end of the first. In low operations it may be possible to use silkworm gut. The bowels siiould, of course, be emptied before operating. After the operation they are best let alone for three days. After that daily loose passages should be se- cured by means of medicines (pp. 242 and 34l). The patient may urinate herself. PART IV. DISEASES OF THE UTERUS. CHAPTER I. Malformations. Malformations of the uterus may be due to excessive develop- ment and precocity, to arrest of development or to irregula?- developraent. Those due to arrest of developraent correspond again either to the fii'st or the second half of fetal life. By bearing in mind the history of the normal development of the uterus (p. 30) the many abnormal forms of uteri due to arrest of this development are easily understood. Since the uterus is formed by the fusion and further development of the middle part of the Miillerian ducts, we have no difficulty in realizing that that part may originally have been absent or may have been destroyed, or that the originally solid filaments may have failed to become tunneled, or that the muscular tissue which should be formed around them may do so in an imperfect way, or that fusion does not take place between the two tubes, or does so only partially, or that only one of the tubes undergoes its regular development, while the other stays rudimentary or is absent.^ A, Excessive Development and Precocity. — Sometimes the uterus in the new-born child has the size and shape of that of a girl at puberty (p. 33). As to menstruation during early childhood we refer to what lias been said on p. 261. B. Arrest of Development during the First Half of Intra-uierine Life — 1. Absence of Uterus. — Complete absence of every vestige of a uterus is a rare occurrence. It may, however, be found in other- wise well built women, but it is mostly combined with other defects in the genitals or in other parts of the body. Diagnosis. — The total absence of the uterus cannot be diagnosti- cated in the living woman, and even in post-mortem examinations the pathologist must be on his guard. ^ Those who want more information about malformations than that warranted by the limits of this book are referred to my article on the subject in the Amer., Syst. of Gynecol; vol. i., pp. 238-257. 406 DISEASES OF THE UTERUS. 407 2. Rudimentary Uterus. — In some extremely rare cases the uterus has only been represented by a solid fibrous or muscular mass. In others it consists of a membranous vesicle. In none of tlie cases of rudimentary uterus authenticated by autopsy was there any menstrual flow, but often molimina. 3. Uterus Duplex Separatus, or Uterus Didelphys (Fig. 248). — This variety is produced when the two Miillerian ducts do not even come Fig. 248. Uterus Didelphys (Ollivier) : a, right body ; /*, left body ; c, right ovary ; d, right round liga- ment ; e, left round ligament ; /, left tube ; g, left cervix ; h, right cervix ; i, right vagina ; j, lefl vagina; k, partition between the two vaginse; I, right tube. in contact with each other in that part of their course in which they usually merge, forming the uterus. Consequently they arc two entirely separate uteri, but each of them represents only one-half of the total organ. Each half lias at its u})per end one Fallopian tube and one round ligament. At the lower end the double cervix opens into a single or double vagina, or this organ may be more or less defective. The uterus didelpiiys is mostly found in still-born children, but occurs also in aduhs.' Pregnancy and childbirth may be entirely normal. It is hardly possible to diagnosticate the uterus didelphys from a uterus bicornis in the living woman, through the closed abdominal wall. ' I have seen one in performing laparotomy on a girl twenty years old. In this case the vagina wa.s normal. 408 DISEASES OF WOMEN. 4. Utenis Unicornis (Fig. 249). — The oue-horned uterus is due to the development of oue of Miiller's ducts, while the other is Fig. 249. Uterus Unicornis with Rudimentary Right Horn (Schroeder) . LH, left horn ; Lo, left ovary ; LT, left tube ; LLr, left round ligament ; RH, right horn ; Ro, right ovary ; RT, right tube ; RL/r, right round ligament. absent or stays rudimentary. It is always very long, forms a curve with the concavity turned outward, and ends in a point without fundus. The diagnosis may sometimes be made by bimanual and rectal examination, the characteristic shape and position being felt. Pregnancy and childbirth may take their normal course. But attached to tlie point where the cervix merges into the body of the unicorn uterus is sometimes found a rudimentary horn. If pregnancy takes place in that, the condition is a very grave one, the rudiment- ary horn being incapable of producing the necessary muscular tissue to form a sac for the growing fetus. The condition is, tlien, practi- cally the same as in tubal pregnancy, from which it cannot be dis- tinguished clinically. Even anatomically the examiner may be led into error, if he does not bear in mind that the round ligament forms the line of demarcation between the uterus and the Fallopian tube (p. 58). A tube, be it ever so narrow, if situated inside of the round ligament, is a horn of the uterus, while the Fallopian tube starts from the same point as the round ligament and extends out- ward. The treatment is also like that for tubal pregnancy — namely, a strong electric current for the purpose of killing the fetus, or removal by means of la])an)tomy or colpotomy. In very rare cases menstrual blood has accumulated in the rudi- mentary horn, forming a tumor (hematomefra). In such a case lapa- rotomy, ligature of the pedicle, and removal constitute the only means of relief. (Compare Salpingo-oophorectomy under Diseases of the Tubes.) DISEASES OF THE UTERUS. 409 5. Uterus Bicornis (Fig. 250). — When the Miillerian ducts remain more or less separated from each other in that part which forms the uterus, this organ appears with two more or less distinct horns at its upper end. There may be a complete partition going all the way down to the external os, so that there is a double cervix, or the cervix may be single, or the partition may be absorbed more or less high up between the two horns, until it is only represented by a ridge at the Fig. 250. uterus Bicornis (Hunkemiiller) : ur, uretlira cut off; hi, meatus urinarius; vag and v«<7*, entrance to the double vagina, tlie anterior wall of which has been removed, showing the two vaginal portions of the two-horned uterus. fundus inside, while the horns are only separated by a corresponding slight depreasion on the outside, so that both the external contour and the cavity have somewhat the shape of a heart on playing-cards. 6. Uterus septus, or bilnculav'is, is a uterus with a complete partition between the two halves, but with the normal shape of a uterus out- side, a kind tliat is of nnich rarer occurrence than the corresponding bicornute variety. If part of the septnni lias been ab.sorbcd, the uterus is called suh- septus — i. e. pai'tially partitioned. In all forms of double uterus, be it horned or not, the vagina may l)e single or double (p. IV)2). The men.strual flow may come from one or i)()th halves, and if from i)oth, it may either come from both sides at the same time or alternately from each half. I'rexpiancji may take ])!ace in either half or in both at once, i^ven if it is confined to one side, the other, as a rule, j)artakes in the pro- 410 DISEASES OF WOMEN. cess, forming a decidua, aud producing muscular hyperplasia and hypertrophy. The presence of a double uterus serves to explain many cases of superfetatlon, an occurrence that is impossible in a single uterus after the third month of gestation. Childbirth takes in most cases a normal course, but complications are comparatively much more frequent than with a normal uterus. Diagnosis. — The presence of a two-horned uterus may sometimes be felt by bimanual examination or from the rectum. The condition of the septum in a double uterus is ascertained by simultaneous use of two sounds, one in either half of the uterus. If there is a communication between the two, the sounds may be brought in direct contact. 7. Atresia Uteri. — Just as we have seen above (pp. 345 and 346) that the hymen or the vagina may be closed, the uterine canal itself, although more rarely, may be the site of atresia. The mucous mem- brane of the vagina may cover the whole vaginal portion without forming an. external os, or the cervix may be one uninterrupted muscular mass without lumen. In such cases the vaginal portion may be well developed or totally absent. In a bicornute uterus one horn may be closed. In regard to symptoms, prognosis, diagnosis, and treatment, we refer to what has been said above in treating of atresia of the hymen and the vagina (pp. 346-349). Wherever the genital canal is closed the symptoms due to retention, such as amenorrhea, pain, menstrual molimina, and the formation of a tumor, are the same. Here we will only mention a few special features belonging to atresia when it is situated in the uterus. The vagina can be ex- plored to its full extent with the finger and the speculum. Above it the uterus forms a round elastic tumor, in the differentiation of which the examiner must especially think of pregnancy, fibroma, and hematocele. In a case o^ pregnancy the patient will, as a rule, have menstruated before being impregnated, and more or less of the well-known signs of pregnancy will be present. A fibroid forms a hard nodular tumor, and causes often menorrhagia. Hematocele appears suddenly and forms a broader mass, Avhicli pushes the uterus for\vard. If the uterus is double, the atresia is found much more frequently on the right side. As a rule, the tumor will begin to form at the time of puberty aud increase with every monthly period, as in atresia of the single uterus, but sometimes the development is slow and irregular. Blood may accumulate in the corresponding tube, which gives way before the stronger uterine wall is ruptured. The closetl horn may become adherent to the anterior abdominal wall, and rup- ture take place through it. The hematometra may also rupture into DISEASES OF THE UTERUS. 411 the stomach or the inte-tine, which leads to septicemia and death. The least daDgerous rupture is that through the partition into the pervious part of the uterus, in which way a permanent cure may be effected ; but in other cases the opening closes again and a new accu- mulation takes place, which in cousequence of tiie entrance of pyo- genic bacilli becomes purulent {pyometra). This abscess may again open into the normal half of the uterus, from which the pus then flows out, or it may burst into the peritoneal cavity, causing septic perito- nitis. (Compare Lateral Pyocolpos, p. 353.) Exceptionally, the contents of the closed horn are only mucus (hi/drometra). If a })urulent collection becomes decomposed, gases are formed in the cavity of the uterus, a condition called jjhysometra. Treatment. — If the uterus is single, a puncture should be made through the cervix with a trocar and enlarged with a bistoury or a metrotome. After evacuation the cavity should be washed out ^vith an alkaline and an antiseptic fluid (p. 346), and an iodoform-ganze drain should be left in the uterus for Ave or six days, and after its removal a perforated intra-uterine glass stem should be inserted in order to keep the cervix ()j)en. J^ater, curetting of the endometrium and packing with iodoform gauze will combat endometritis and help to bring the distended and, as a rule, hypertrophied uterus back to a normal condition. If the accumulation is found in one half of a double uterus, it is still an advantage, if possible, to enter through the cervix, but often there is no choice and the tumor must be punctured at its lowest point in the vagina. Puncture alone, even rej)eated, rarely effects a cure, and it should, therefore, be followed by an incision, or even an exci- sion, of a portion of the wall, so as to insure permanent communica- tion with the open half of the genital canal, ^^'hen the closed half has been ])unctured and evacuated it may be possible to dilate the open half by Vulliet's metho<l (p. 159) and remove a part of the partition between the two halves of the uterus. If the swelling cannot be reaciuHl from the vagina, laparotomy should be performed and the affected horn or the whole uterus re- moved as for a flbroid, Jf blood has collected in the Fallopian tube, and there is no com- nnuiication with the uterine cavity, it is best to let it alone, as it may perhaps be reabsorbed. It' the tubal sac grows, it may be punctured from the uterus or tiie vagina, and in the latter j)lace treated with injection and drainage. Laparotomy and removal of the distended tube may be tried, but it is liai)le to })r()ve difHcult or imjK)ssible on account of adhesions. C. Arrest of Development dnrinf/ the Seeoyid Ihtlf of Infrd-vfertne Life. — L Fet(d (tnd Jufoidile UteruK. — Some adult women have a womb that in size and configuration corresponds to that of a fetus 412 DTSEASES OF WOMEN. toward the end of pregcnancy or that of a young chihl. Sometimes it is only an inch and a half deep ; in other cases it has the size of a virgin uterus, but is characterized by the preponderance of the neck over the body and the thinness of the walls of the latter. The folds of the mucous membrane may either be confined to the cervix or extend more or less up into the cavity of the body. The fetal uterus may at tiie same time be two-horned (p. 409), as the result of a double arrest of development. The other organs may be normal, but often the condition is combined with other abnormali- ties, especially of the ovaries. 2. llie pubescent, or congenitally atrophic, uterus is one that is char- acterized by its small weight, which does not exceed one ounce, but the cervix and body have about the same length. Etiology. — Besides simple arrest of development from unknown causes, exudative perimetric inflammation, chlorosis, and tuberculosis may cause the deficient development of the uterus. Symptoms. — Menstruation is, as a rule, absent or scanty. Often the patient suffers from dysmenorrhea, and sometimes vicarious men- struation (p. 258) takes place. All sorts of disorders in organs out- side the pelvis (pp. 264-267) may occur with, or instead of, the men- strual flow. Sexual appetite may be unimpaired, but as a rule women with too small a uterus are sterile, or if they conceive they are apt to abort. Sometimes the scant development of the uterus is allied with goiter. There is, indeed, an intimate connection between the uterus and the thyroid gland. It may be a poetic fiction when Catullus sings that on the morning following the bridal night the string that formerly encompassed the girl's neck is found too short ; but medi- cal observation has found a decided connection between the thyroid gland and the chief uterine functions. Thus, the thyroid often is the seat of swelling at approaching pul)erty, and resumes, as a rule, its normal proportions after the establishment of menstruation. In many women tlio gland swells before each menstrual period. In many cases goiter is referable to ])regnancy ; and it is even stated that while goiter was being treated with electricity, the susceptibility to impreg- nation was much increased. At the menopause the goiter does not always diminish or disappear. On the contrary, it may increase.^ Prognosis. — Tin; prognosis, especially in regard to sterility, should be guarded, but a late develo})ment of the uterus, leading to concep- tion and childbirth, has been observed. Diagnosis. — The condition can, as a rule, be made out by palpa- tion, especially tiirough the rectum, and the use of the sound. ' Charles R. Dickson, of Toronto, (Ontario, " Observations on the Relations of the Uterus to the Thyroid Gland," Amer. Jour. Surg, and Gynecol., Oct., 1899, vol. xiii., No. 4, p. 63. DISEASES OF THE UTERUS. 413 Ti'eatment. — If tuberculosis or chlorosis is present, the practitioner should carefully abstain from any local treatment that is likely to bring on the courses: the patient being anemic, her condition will only become worse by losing blood. In such cases a general tonic treatment is indicated (pp. 240-245). If the patient is in good health, and sterility the chief complaint, galvanic treatment with the negative pole in the uterus and faradiza- tion have often good effect. If she suffers from dysmenorrhea, vicarious menstruation, and dys- nienorrlieic disorders outside of the pelvis, she should be treated according to the rules laid down above (pp. 258, 260, 261, 266) in discussing those conditions, especially with tonics, a strengthening regimen, sedatives, electricity, and the uterine sound. 3. Uterus ParvicolUs and Acollis. — Sometimes the body of the uterus is well developed, but the cervix is too small, or the vaginal portion is absent. In other cases tiie body is likewise too small, but the hypoplasia is most pronounced in the neck. These deformities have more pathological than clinical interest. 4. Anteflexion of the uterus is often congenital, and sim})ly a con- tinuation of the shai)e of the uterus found in the fetus and young children. This condition will be considered together with other dis- placements of the uterus. D. Irregular Development. — 1. Obliquiti/. — The uterus may be con- genitally bent to one side {later oflexion), the two Miillerian ducts that formed it not having kept pace with each other. Or a similar con- dition may be i)ro(luced by fetal peritonitis and cicatricial shrinkage of one of the broad ligaments. A normally shaped uterus may be tilted to one side (later over sion), especially when there is a beginning ovarian hernia. 2. MalpoHilion. — In consecpience of an uneven development of the broad ligaments the uterus may be placed not in, but to one side of, the median line of the pelvis, latcropo.vtion. A similar irregular development of the parts situated in front of and behind the uterus lea<ls to a)Uej)o.'<ition, when the uterus is situ- ated too near the symphysis, or rvtropositlon, when it is drawn too near to the sa(!rum. 3. Hernia Uteri. — ^The uterus has been found in a congenital inguinal hernia. Jn such ca.ses the ovary descends first through the inguinal canal, just as the testicle descends, or rather is drawn, into the scrotum. TIk; uterus has also been found in a crural her- nia. Such herniie are exceedingly rare. The pjitient mav become impregnated and the ictus develop in the hernia, whence it has to be removed by Cesarean section with or without hvsterectoniv. If the condition comes und<'r observation earlier and gives Iroubh'. hvsterectomy might be jxTlormed. 414 DISEASES OF WOMEN. 4. Elongated Cervix and Stenosis of the Cervical Canal are often found as a congenital irregularity, but will be treated of together with the same conditions when acquired later in life, in a subsequent chapter. (See Hypertrophy of Uterus). CHAPTER II. Injuries. A. Injuries of the Body. — On account of its position in the depth of the pelvic cavity the uninipregnated uterus is little exposed to injuries, but when during pregnancy it rises up from the pelvis and rests gainst the abdominal wall it is so much more frequently the seat of traumatic lesions, such as goring with a bull's horn, kicks with heavy boots, stab-wounds, or shot-wounds.^ While in such cases injury is inflicted through the abdominal wall, the pregnant uterus is exposed through the vagina to the manipula- tions of abortionists. In reading the evidence in suits for malpractice one is at a loss to decide whether the rascality, the recklessness, or the ignorance of these j)eople is the greatest. In their eagerness to destroy the fetus they sometimes make a wound in the uterus large enough to admit the thumb and allow the intestines to enter the uterus.^ But even in legitimate gynecological operations the uterus is occa- sionally wounded. Some uteri are so soft that they are easily pene- trated by the sound or the curette. Sometimes in performing lapa- rotomy, the gravid uterus has been mistaken for an ovarian cyst, and a trocar thrust into it.^ In regard to rupture of the gravid uterus during labor the reader is referred to works on obstetrics. Frognoids. — With the exception of the simple perforation of the uterus with soiuid or curette, which if the instruments are clean, and injection of irritating fluid is omitted, has no bad consequence, most of these injuries are very serious, lead, as a rule, to miscarriage, and are sometimes accompanied by hemorrhage or peritonitis and death. Still, if the ovum has not been opened, and occasionally even after evacuation of the liquor amnii, pregnancy may take its course to term. In those cases in which a })regnant uterus is ripped o})en by the horn of cattle the prognosis is better than one would expect from the vio- ' An interesting case of tlie last kind was reported by Dr. George A. B. Hays, of Plaqueminos, La., in Gaillards Med. Jour., Nov., 1S79, p. 402, ct.seq. * Ca.ses of tliis kind were mentioned by Thomas, IMunde, and Na'ggeratli in the N. Y. Obst. Society, April -5, LSSl, Amcr. ,Ioiir. Obst., 1882, Supplement, p. 5. ^ An interesting paper on this subject by Dr. C. C Lee is found in Trans. Amer. Gyn. Soc., 1883, vol. viii., p. 154. DISEASES OF THE UTERUS. 415 lence of the injury, which can only be accounted for by the excel- lent health of the persons wounded in this way.^ Treatment. — In cases of wounds through the abdominal wall, rest, opium, and antiseptic dressing of the Avound probably offer the best chances ; but if there are signs of internal hemorrhage, laparotomy shouhl be performed and the bleeding vessel tied. If possible, the fetal sac should not be disturbed. When the uterus has been wounded from within, as a rule, no treat- ment but rest is required. If there is prolapse of the intestine, lap- arotomy should be performed in order to withdraw the intestine and close the uterus. If the intestine is gangrenous, part of it may be resected ; or it may be left undisturbed, when an intestino-iiterine fistula will form, a condition that not only is compatible with life, but may be cured by nature's sole efforts (p. 400). If the gravid uterus is punctured in laparotomy and the ovum opened. Cesarean section should be performed ; but if the trocar does not enter the ovum, the opening in the uterus may be closed with catgut sutures, and pregnancy allowed to take its normal course. B. Laceration of the Cervix. — By far the most common injury to the uterus is that sustained by the cervix during childbirth, when it is ruptured, or lacerated, that is to say, torn. Pathological Anatomy. — These tears occupy always the direction of the radius of the os. They may be complete — that is to say, go through the whole thickness of the cervix — or incomplete, when the tear in the cervical canal does not reach the mucous membrane of the vagina. There may be one, two, or many tears. The one most com- monly observed is the bilateral, and next to that the unilateral, which is more frequent on the left than on the right side, doubtless on account of the greater frequency of the left occi pi to-anterior j)osi- tion of the fetus. The laceration may also be .stellate; that is, the oc- currence of at least three tears forming a starlike figure. It \h funnel- shaped when there are several incomplete tears, which result in a patulous OS. Sometimes it l)ecomes crescentic through the bulging of a hyperj)lastic anterior lip. In other cases the tear is Ibund in the posterior or anterior lip alone.^ The tear extends often more or less beyond the vaginal junction and enters tiie ])arametritim or the connective tissue beiiiiKl the uterus, or extends into the bladdcir. Often it gives rise to cellulitis in these l)arts, which through cicatricial contraction may lead to displacements ' Out of 14 cases 9 rccovcrid, K. 1*. Harrison, Amrr. Mai. Jour. Sri., Oct., 1S!)1, vol. cii., p. 87(i, and .Monograph : Ahdnminal <uid Uterine Tolerance in J'rri/n/tni Women, Philadelphia, ISD'J, ],\>. iL' lo. ' Most of those varieties are hcaiitifidly represented on colored plates a<'conipaii_v- in^an excellent article on tin; Indirotiona for Hi/^trro-trachelorrhup/iy by 1'. F. Miindd in the Amrr. Jour. (JbM., 1879, vol. xii. p. l.'U. 416 DISEASES OF WOMEN. of the uterus. If the tear implicates the bladder, it may leave a vcsico-vaginal or vesieo-uteriue fistula (pp. 383 and 390). Commonly the laceration of the cervix is followed by chronic inflammation of the neck and the body of the uterus. In conse- quence of hyperplasia and hypertrophy of the glands of the cervical mucous membrane, infiltration with round cells in the interstitial connective tissue, which later are replaced by new fibers, and abnormal afflux of blood, tiie mucous membrane becomes swollen, red, and rolls out iectropium), and the lips become separated, a condition which is increased by pressure against tiie posterior wall of the vagina. Often the outlet of the glands becomes closed, and then small round cysts are formed, which are filled with a fluid like the raw white of an egg, feel like shot, and appear as translucent yellowish spots. The connective tissue in the muscular layer of the cervix becomes also hyperplastic, so that the cervix becomes larger and harder than normal. The lips, especially the anterior, become elongated. The body of the womb does not undergo the normal involution, but stays large and heavy, and becomes the seat of a chronic inflammation. Tears may heal completely by first or second intention, but in the latter case the process is often incomplete. : a cicatricial plug of hard connective tissue is formed in the angle between the lips, and the lower part of these does not unite. On the other hand, the tear may heal from the tip of the cervical portion to near its base, leaving a small opening, which constitutes a utero-vaginal fistula without importance. A similar opening may remain after artificial closure. Symptoms. — In the moment the laceration takes place, it may be accompanied by arterial hemorrhage. An old laceration also fre- quently gives rise to abnormal loss of blood, be it menorrhagia or metrorrhagia (pp. 2G2 and 204) from the cervix or from the endometrium of the body. In the interval the i)atient suffers from leucorrhea. This double drain soon produces anemia. The patient loses her strength. She easily gets tired, becomes nervous and irritable, and often has neuralgic pain in the localities de- scribed above (p. 136), and sometimes strangely perverted sen- sations and hallucinations.^ She loses her appetite, her nutrition becomes insufficient, she is pale, and lier features have a suffering expression. Laceration of the cervix is often accomjianied by secondary ster- ility, probably in consequence of the uterine catarrh to which it gives rise. Tlie hyperplastic li})s and the unyielding cicatricial })lug in the ' A curious instance of this kind is found in my paper on Laceration of the Cervix Uteri, Archives of Medicine, October, 1881. The same paper contains a description of the microscopical composition of the tissue removed in trachelorrliaphy, and a case illustrating the obstetric indication for the operation. DISEASES OF THE UTERUS. 417 angles between them oppose a considerable resistance to the dilatation of the cervix in childbirth, entailing a tedious and painful labor. Digital examination reveals the tear in the cervix, the thick, vel- vety everted mucous membrane, often studded with small hard bodies formed by the obstructed glands. Pressure with the nail in the angle causes often great pain on the spot or in remote places. The condition is best seen by means of Sims's speculum. The tubular speculum, by pressing the lips apart, is apt to conceal the true condition entirely. The bivalve is liable to make the laceration and ectropium appear larger than they really are. In general, the laceration is plainer to the touch than to inspection, but when exposed by means of Sims's speculum the original shape of the cervix may be approximately reproduced by hooking a tenaculum into each lip in front of the red cervical membrane, where the os uteri was situated before the laceration occurred, and pulling the two lips against each other. Diacjnosis. — By the means just indicated it is easy to demonstrate the laceration. Sometimes the hyperplasia of the lips and the cystic development may be so great that the diagnosis from cancer may become difficult, but the effect of treatment will soon dispel all doubt. Some women have a congenital cleft of the vaginal portion in one or two places. The lips thus formed may become tiie seat of a chronic inflammation, and thus a condition may be brought about in a uuUip- arous woman that is entirely like a bilateral laceration.' Prognosis. — Many lacerations of the cervix heal spontaneously and give rise to no trouble. Sometimes the nervous phenomena men- tioned above may, however, develop even if tiie tear is completely healed. If the laceration is neglected, the whole constitution suffers, as we have seen above, and even a phthisical condition may be the end. Tears of the cervix seem also decidedly to pretlispose to cancerous degeneration. If properly treated the laceration and its consequences may be entirely cured. Treatiiicnf. — The prophylaxis consists in abstaining from giving ergot or other ecbolic drugs, from pressing on the fundus uteri, or from using the forceps before complete dilatation has taken place. On the other hand, the use of drugs that favor dilatation of the cer- vix, sudi a.s belladonna, chloral, and antipyrin is beneficial. The accoucheur should not feel or looU for lacerations of the cervix ' I have treated a <rirl who was ahout twenty years old and liad an antellcxion of the womb. The liyini'ii was not rnf)tnr('(I, lint very lax, prohahly in consonncnce of iMastiirl)ation. The anterior vajfinal wall was everted, 'ilie cervix was split into an anterior and a jiostcrior lip, wliicli were entirely separated, and hent forward and backward into the fornix. Tlu' openinj^ in the cervical canal formed a transverse slit \ inch wide. The anterior lip ineasnred 1 inch, the jiosterior ] inch in Ien<rlh. The everted mucous memlirane was edematouH, tiled easily, and was covered with abundant jrlairy mucus. 27 418 DISEASES OF WOMEN. except in case of arterial liemorrhage.^ Otherwise he exposes his patient to infection, that may do much more harm than lacerations, most of whidi probably heal spontaneously. If, however, a fresh tear has been discovered and gives rise to hemorrhage, it should be closed with sutures. If circumstances do not allow of such an operation, a very densely packed tampon and a tightly fitting T-bandage suffice to arrest the hemorrhage (p. 185). Fresh tears that do not bleed may be treated with antiseptic vagi- nal injections or the application of a strong solution of nitrate of silver (^i-si)-^ Old tears are treated differently, according to their size and the other local and general conditions. Small nicks round the os may be looked upon as a nearly normal incident of childbirth and need no treatment. Medium tears are often cured by curetting, and the application of liquor ferri subsulphatis, twice a week, or pledgets with glycerite of tannin (si— §i), changed morning and evening, and the use of hot vaginal injections. Unilateral tears can, as a rule, be treated successfully in a similar way. Large bilateral tears, or even healed tears if they cause neuralgia, call for operative help, an operation that is called after its inventor Emmet's operation, trachelorrhaphy {i. e. neck-sewing), or, more explicitly, hystero-trachelorrhaphy {i. e. womb-neck-sewing). Preparatory Treatment. — Before performing this operation the in- flamed mucous membrane should, however, first be treated with tinc- ture of iodine, Monsell's solution, chloride of zinc solution, sulphate of copper solution, or tannin glycerite, and hot douches (pp. 175, 182, and below under Chronic Metritis). Cysts should be pricked with a scarifier and painted with Churchill's tincture of iodine. This preparatory treatment may take several months. If circum- stances do not warrant so protracted a treatment, the whole mucous membrane may be excised at the time of the operation. Trach.elorrhapliy . — The pubic hairs having been shaved off and the genitals, inclusive of the vagina, disinfected, the patient is placed in the dorsal ])osition, the legs tied with Kobb's legholder, and the perineum drawn back with a single Sims speculum or Gar- gues' weight speculum (Fig. 192). A Schroeder vaginal retractor (ji. 227) helps often consideral)ly in making the parts accessible. I use strong full-curved trocar-])ointed needles, 1^ inches long, \\ inches the straight line from end to point (Fig. 201, g), and Crosby's needle-holder (Fig. 204). 1 Garrigues, "The Immediate Closure of the Laceration of the Cervix," Amer. Jour. OhKtPt, vol. xxiv. No. 11, 1891. ^ Elwood Wilson, Gynecological Trans., 1886, vol. xi. p. 92. DISEASES OF THE UTERUS 419 I begin the operation by seizing the lips separately with a bullet- forceps, pulling the uterus gently down, and inserting a strong linen or silk thread through the middle of each lip. These guys serve to steady the uterus, separate or approach the lips, mark the canal which is to be kept open, and they facilitate the operation very much. Next, a tenaculum is hooked into the cervical mucous mem- brane on one side of the posterior lip. With a scalpel a piece is cut off going in under the tenaculum, and the strip is continued into the angle of the tear. Many use scissors. The great variety of those invented suggests, however, that others have had similar difficulties to those experienced by the writer, until he replaced tlie scissors by the knife. Often it is easier to begin by cutting right into the angle from the cervical canal to the vagina or vice versd. A corresponding surface is denuded on the anterior lip. Then similar strips are cut off on the other side, leaving an undenuded surface corresponding to the cervical canal. This ougiit to be about half an inch wide at the os, as con- traction always takes place later, and would result in too narrow an Fig. 251. Diaprnm Illustrating Triichelorrliapliy in a rase of Bilateral Laceration: A, posterior lip; B. anterior lip; C, cervical canal (apparent os surrounded by reel and swollen iiuieous mem- brane, which used to bo ri'cariU'd as an ulcer). The numbers mark the order in which the sutures are inserted. Wlieii Ihey are tied A comes in contact with li and forms the real os (e.f, r/, k). The render can easily realize the whole ellect of the operation by copy- Inx tlii.s (iKuVe on a piece of [taper and folding It at a line uniting D and J), which repre- sents the angle between the lips. OS, if there had not been tissue enough left. Particular care should be taken to remove tlu> <'i(;atricial plug from the angle. The cut surfaces bleed freely, but there is, as a rule, no hemorrhage of <!onse(juence. The result of the cutting i.s that we have four denuded surface,-;, i'aeh two of which are continuous in tlu^ depth of the angle, and between the denuded surfaces a tnunpet-shaped undenuded ])iece 420 DISEASES OF WOMEN. of mucous membrane is left on the anterior and posterior lips of the cervix (Fig. 251). The second step is to introduce the sutures. The first needle is pushed in a quarter of an inch outside of one of the denuded surfaces of the posterior lip near the angle. It is passed transversely under the denuded surface and made to emerge just on the line of deinarka- tion between this and the undenuded central portion. Next, it is inserted on the corresponding point of the anterior lip, and carried under the denuded surface and made to emerge a quarter of an inch outside of it, on a point cor resjwn ding to the first in which the needle entered. When the point of the needle emerges anywhere, the assistant holds the counter-pressure hook (p. 235) in under it, and presses against the tissues in order to facilitate the passage of the needle. The best suture material is chromicized catgut (Leaven's No. 2). As a rule, three such sutures are inserted on either side, and when they all are in place, they are tied and cut off, beginning nearest the angle. Before and after closing the sutures I thoroughly irrigate with lysol. Originally, the operation was performed in Sims's position, but the insertion of the needles and disinfection are much facilitated by the dorsal position. After having described the most common form of trachelorrhaphy w-e must mention some of the many conditions that call for a modifi- cation of the operation. Modifications. — If it has been necessary to cut veiy deep into the angle between the lips, the wound cannot be closed in a reliable May by inserting the sutures from the vagina as described above. Then the uppermost should go much deeper in than it is possible to get it when starting from the vagina. This is obtained by using two needles and a carrier of silkworm gut. One of the needles, threaded with one end of the suture, is introduced from the cervical canal and puslied out through the posterior li]) ; the other, attached to a loop of silkworm gut, is in tlie same way carried from within outward, through the anterior lip. Next the free end of the suture is passed through the loop, and the latter pulled out through the anterior lip, carrying the suture witli it. In the unilateral tear only one side is operated on. In the stellate tear it is sometimes necessary to cut off a whole lobe between two fissures on one or even both sides. If there is much glandular hypertrophy and cy.stic degenera- tion, it may be necessary to remove the whole mucous membrane from one or both lips. This may be done at the time of the operation by omitting to leave an undenuded strip in the centre for the canal or by curetting it. If this is done on both sideS; DISEASES OF THE UTERUS. 421 some provision must be made for preventing the cervical canal from growing together. I have used an intra-uterine glass stem for the purpose or introduced a sound repeatedly during the heal- ing process. Others leave a silk thread or reopen the canal by electrolysis.* When there is much hy|)erplasia, so that the lips stand far apart, and when brought together oiler two convex surfaces, it is necessary to hollow the denuded surfaces well out in order to approximate them. If one lip is longer than the other, the position of the angle must be changed by cutting the tissues in such a way as to get the angle over on the longer lip, and thus obtain two lips of the same length that will form a regular os. If besides the cervix the ]>erineum is torn, we are in general com- pelled to do both operations at one sitting ; but if secondary hemor- rhage, necessitating tamponade, were to ensue, the perineal work would be destroyed ; and if menstruatit)n were to come on unex- pectedly, which sometimes happens, it might be hard to diagnosti- cate (p.' 239). As a rule, the loss of blood is so moderate that the operator need not pay attention to it. If, in very exceptional cases, the circular artery bleeds considerably, the deepest suture should be inserted im- mediately on the bleeding sid(\ As soon as the two lips are in appo- sition all bleeding stops. In rare cases it may be necessary to cut out a cicatrice from the fornix of the vagina. Here also an artery may spurt that should be seized with pressure forceps. It will hardly be necessary to tie any artery. If the operator has denuded a larger surface than he can cover, serious hemorrhage may follow, which, however, can be controlled with styptic cotton and u tampon of comm(m cotton, and need not interf(.'re with a perfect result. Great care should be taken to have a perfect line of union, the vaginal mucous membrane on one lip coming in contact with that of the other. If nec^essary, superficial plain catgut sutures may be inserted besides the deep sutures. If the lips of the torn cervix are adherent to the vaginal wall, the adhesions should be sej>arated sufficiently to allow the lips to be brought together. The gaj) made by the incision in the vagina should be i)acked with iodoform gauze. Upon ti)e wliole, small as the field is, atid free from danger as the operation is, if performed aseptieally, trachelorrhaphy requires, in my opinion, as much judgment and skill as any other gynecological operation I know of. ' fJeoPKe Kngelmaiin of St. Louis, (hjn. Trans., 1S85, vol. x. ]>. "JO'J, and 188{), vol. xi. p. 90. 422 DISEASES OF WOMEN. At the end of the operation I cover the cervix with a long strip of iodoform gauze, packed loosely into the fornix of the vagina. The patient may urinate hei-self. The bowels are kept open if necessary. On the fourth and the seventh day tlie tampon is changed and the vagina swabbed with antiseptic solntion. On the tenth day the sutures and the tampon are removed, and some vaginal injection administered morning and evening. The patient stays nine more days in bed. The eifect of the operation both locally and as to general health is wonderful. The womb diminishes in size, the nervous phenomena disappear, the patients grow fat, a new period full of comfort and blooming health follows in the course of a few months, and very often conception puts an end to sterility. The stitched cervix may, of course, be ruptured in a new labor, just as the intact cervix was, but very often it goes uninjured through subsequent childbirths. CHAPTER III. Foreign Bodies. Foreign bodies are by far not so common in the uterus as in the vagina. Still, occasionally an intra-uterine instrument, especially a glass tube, may break and the end remain inside, or absorbent cotton used for applying drugs to the interior may come off. Sometimes a leech applied through Fergusson's speculum to the vaginal portion has slipped into the interior of the womb (p. 194). A hairpin used to produce abortion has also been found there. A Hodge pessary slipped from the vagina into the cervix while the patient lifted another person.^ Treatment. — If any object is in the womb which cannot be with- drawn, the patient should be anesthetized, the cervix dilated, and the foreign body removed with finger, curette, or forceps. If it be a living leech, a strong solution of table-salt injected into the womb will make it loosen its grip. If there is any hemorrhage, the uterus 1 Henry Heiman, iMed. Record, March 17, 1894, p. 347. DISEASES OF THE UTERUS. 423 should be tamponed with iodoform gauze, and if that does not suffice, the vagina too must be plugged (p. 183). CHAPTER IV. Metritis. Metritis is inflammation of the uterus. As in vaginitis a large number of different forms of metritis are described according to the special part affected, the cause, the course, and certain peculiarities. As this is not a treatise on morbid anatomy, but above all a guide to the recognition of the diseases of the female genitals and their treatment, it would not only lead us too far, but cause unnecessary repetition and confusion, if we were to admit all these distinctions as special diseases. We will only mention such varieties as are clinically distinct or call for different treatment. In regard to time and severity of symptoms we distinguish l)etween acute and chronic metritis. Acute Metritiii. — In the acute inflammation the whole organ — body, cervix, nnicous membrane, muscular laver, and peritoneal covering — is more or less implicated. The peritoneal inflammation — so-called peri- metritis — is, however, not always found, and if found extends gener- ally to neighboring parts of tiie peritoneum, and will, therefore, be treated of under Pelvic Peritonitis. The inflammation of the nnicous membrane is called endometritis, that of the nuiscular layer pdrenchi/mutoiis laetritiH, that of the cervix has been designated as cerricitis, and that of the raucous membrane of the cervix as rndorcrrlciti.s. Pathological Andtoiinj. — The whole uterus is enlarged and softened, the cut surface is red wi(h yellow points. The nnicous membrane is swollen and red. Micn)Scoj)ical examination shows both in the mucous membrane and between the nuis<;le-fibers an abundant inliltration with small round cells, dihited biocKl-vessels, and masses of extravasated blofnl. The inflammation extends sometimes to the pei'itonenin and the pelvic connective tissue, eitiier through the tubes or through tiu; lympathics (p. (i3). Sometimes it is combined with vaginitis. 424 DISEASES OF WOMEN. It is doubtful if ever an abscess be formed in the uterine tissue, except in ]>uerperal cases, where tiie metritis appears as part of a more comprehensive infection. Etiology. — Menstruation being accompanied by a development that has much in common with that of inflanmiation, predisposes to the latter. Thus exposure to wet or cold is more liable to end in acute metritis during the menstrual period than at other times. Coition during menstruation may have a similar effect. Parturition and mis- carriage are the most common causes, either through, direct puerperal infection or as a predisposing element : if a woman who has recently given birth to a child or aborted, fatigues herself, catches cold, or has sexual intercourse, slie is more liable to have an acute inflamma- tion of the womb than otherwise. Coition ought not to take place before involution is completed — say, two months after childbirth and one month after early abortion. Acute metritis may be brought on by any gynecological operation, even the mere introduction of a sound, and still more easily by curet- ting, or by the irritation caused by an intrauterine stem or even a badly- fitted vaginal ])essary. Trachelorrhaphy or incision of the cervix has often led to endometritis extending through the tubes to the peritoneal cavity and ending fatally. Retained blood may become decomposed and cause acute metritis. The true agent in all tliese cases has been found to be the introduction of pathogenic microbes into the uterus, which normally does not contain microbes. Acute metritis a])pears sometimes in the exanthomatous fevers, typhoid fever, cholera, acute yellow atrophy of tlie liver, phos- phorus-poisoning, and in persons affected Avith syphilis. As we have seen above (pp. 133 and 310), gonorrheal infection sometimes invades the uterus. Symptoms. — Acute metritis is accompanied by fever, a sensation of heat in the pelvis, bearing-down pain, a painful sensation of contrac- tions called cramps, or pain extending up to the lumbar region. Sometimes the patient com])lains of vomiting, diarrhea, dyschezia, and dysuria. Often she suffers from suppressio meusium or menor- rhagia, or has a purulent discharge from the uterus. In gonorrheal metritis there is especially an abundant secretion of thick creamy, often blood-tinged ))us, teaming with gonococci. The abdomen is tympanitic and tender. Vaginal examination reveals a hot vagina, a swollen, congested cervix, with patulous, often eroded, os, and a large, soft, tender uterus. Prognosis. — In most cases the disease ends in recovery in the course of from two to four weeks. Repeated attacks of acute metritis are, however, liable to end in chronic metritis. The ]>ossibility of the extension of the inflanmiation to the tubes and the peritoneal cavity. DISEASES OF THE UTERUS. 425 especially in gODorrheal and septic metritis, must also make us cau- tious in our prognostication. Treatment. — Pi'ophyloxis. — A ])erusal of the causes of acute metri- tis gives the necessary indications in regard to how to avoid the dis- ease. At the time of menstruation, in the puerperal state, and after abortion, women should be particularly carel'ul to avoid too great bodily exertion and exposure to cold. They should abstain from sexual intercouree. Obstetricians and gynecologists should use all antiseptic and aseptic precautions, even in normal deliveries, as well as small gynecological manipulations and operations. Curative Treatment. — The j)atient should stay in bed. An ice-bag or ice-water coil should be applied over the symphysis (p. 195), except when the cause is suppression of menses by exposure to cold. In the latter case a warm poultice or hot-water bag is substituted. If there is no bleeding, some bloodletting by means of leeches, the artificial leech, or sim])le scarification (p. 194) sometimes affords considerable relief; but all these manipulations necessitate the use of a speculum, and, if the tenderness is great, this does more harm than good. Vaginal douches of plain warm water should be administered three times a day or oftener. In these acute cases lukewarm water (100°-10o° F.) has often a more soothing effect than the hot (110°- 120°). The addition of flaxseed or slij)pery elm increases perhaps this effed of the douche somewhat (p. 176). A lukewarm sitz-bath (p. 196) once or twice a day or a general warm bath every other day is also useful, if the slight movements insej)arable from these procedures do not hurt the patient. Ano- dynes are best given as opium suppositories (p. 243). Five grains of (piinine should be given every four hours, and the bowels kept open. When the most acute symptoms have subsided, the ice-bag may to advantage be exchanged for Prieszuitz's eompress (]). 195), tincture of iodine may be painted on the abdomen and on the roof of the vagina (p. 196), and ^lye(;rin tampons (j). 183) may be introduced into the vagina. If the discharge is purulent, the uterus should l)e curetted. Gonorrheal metritis necessitates a more active treatment. The ute- rus should be washe<l out (p. 176) at least once a day with a solution of corrosive sublimate (1 : .'>()00), permanganate of potash (1 : lOOOj or chloride of zinc (1 : 100). Twice a week the interior of the uterus should be painted all over with a solution of chloride of zinc (20 jier cent.) or nitrate of silver (1 : 12). 8ome use curetting (p. ISO). A milder treatment, with a somewhat siuiilar etlect, consists in i)ackiMg the uterus once or twice with iodoform gauze (p. 1H5) in order to remove all pus and some of the epithelium, and finally leaving a 426 DISEASES OF WOMEN. Fig. 252. strip well dusted with iodoform in the uterus. Far from causing pain, it seems to have a soothing effect. Diphtheritic Metritis. — A particular variety of the acute metritis is the diphtheritic, in which there is a yellow exudation in and on the endometrium. This condition is mostly due to puerperal infection, but is also found as part of general diphtheria. It occurs com- bined with gangrene of the vagina (p. 372) in scarlet fever, typhoid fever, cholera, and other infectious diseases. In puerperal cases the diphtheritic infiltra- tion may extend in a layer from the endome- trium to the neighborhood of the peritoneum, cutting off a large part of the muscular tissue, which, after weeks or months, is expelled as a pear-shaped body (Fig. 252), a condition which is little known, but of which I have observed and described under the name of dissecting metritis not less than eight cases.^ Diphtheritic metritis is, as a rule, combined with a similar condition in the vulva and the vagina, and may be made visible when it at- tacks the cervix. Dissecting metritis cannot be diagnosticated before the loose body is ex- pelled, but its existence may be surmised, if after diphtheritic vaginitis and cervicitis there continues an abundant purulent discharge from the uterus. If the cervix is attacked, its whole inner surface should be thor- oughly painted once with chloride-of-zinc solution, 50 per cent. The uterus should be washed out with carbolized water once a day. An iodoform pencil I^. lodoformi, 3v; Amyli, 3ss; Glycerini, fl. gss ; Acaciee, 3j. M. Sig. Divide in three suppositories of the size and shape of the little finger. should be introduced up to the fundus and left to melt. The internal ' Specimen expelled by B. E. at Maternity Plospital, on Oct. 20, 1883. This was the eighth case of the report published in N. Y. Med. Record, vol. xxiv. p. 664. The figure taken from a photograph is a little below natural size. ^Garrigues, " Dissecting Metritis," New York Medical. Journal, 1882, vol. xxxvi. p. ^37 ; Archives of Medicine, April, 1883; and ArchivfUr Gynakologie, 1890, vol. xxxviii, p. 511. Dissecting Metritis.i DISEASES OF THE UTERUS. 427 treatment consists in tlie administration of quinine, stimulants, strychnine, and chloride of iron. Some recommend in severe puerperal infection hysterectomy and removal of the appendages, either by the vaginal method or abdom- inal section. The operation is said to be especially indicated when there are foci of suppuration or infection in the uterine body, an in- fected endometrium, persistent' metrorrhagia, or widespread sup- puration and disintegration of the broad ligaments. In the writer's experience these patients are in most cases too w-eak to stand so serious an operation, and the operation itself often spreads the infec- tion. In the majority of cases better results may be expected from medical treatment, opening and draining of abscesses, etc. More radical operations are often postponed to advantage till the patient has gained more strength. B. Chronic Metritis. — While we have treated of the acute form of metritis as one entity without distinguishing between the inflanmia- tion of the mucous membrane and that of the muscular tissue, in regard to the chronic form of inflammation of the uterus, it is bet- ter to describe endometritis and parenchymatous metritis separately. It is true that the inflammation of the mucous membrane always extends somewhat into the muscular layer, and that an inflammation of the latter always implicates the former, but still there are marked clinical differences between the two, and certain points in the treat- ment apply only to one or the other. 1. Chronic Endometritis. — Pathological Anatomy. — In the chronic form of endometritis the mucous membrane of the uterus is swollen, soft, friable, of dark red or slate color. In some places are seen ecchy- moses. On account of the swelling the mucous membrane does not find room enough in the uterus and bulges out through tlie os, form- ing a so-called ectropium. The glands of the cervix become occluded and form cysts most of which are small as hemp-seed or peas, and shine with a white or yellow color througli the surface of the vaginal j)ortion. In olden time these retention cysts were mistaken for the human ovulum and are yet known under the name of ovula of A«- Ijiifh. Occasionally these cervical cysts acquire, however, the size of a c;herry. When pricked open a thick colorless fluid, like tlic raw white of an egg, flows out from them. The interior of the body has lost its even smoothness, and is raised in ridges or in pa))illarv growths, or long club-shaped polypi hang from the finulus and th(! side walls. This has been (les('rii)ed under the name of hifjier- plastir or fiinf/oiis riKlonicfrifis. Similar iiikcou.s polypi (Fig. ^ol) form in the mucous membrane of the cervix, and may hang out from the OS as pednneulatcd tumors. Around the os, on the outer surfiiee of the vaginal ])ortioii, is found a red velvety area, and similar red spots may be found 428 DISEASES OF WOMEN. Vui. 2o3. further out on the vaginal ])ortion, apart from the os. They are oh^nx called erosions, and thev form what is known as a (jranular os. Thoy used erroneously to be called ulcers of the cervix, an expression that is yet often used by patients. Microscopical examination siiows that the swelling of the mucous membrane in chronic endometritis is due to a great de- velopment of its glands, to iniiltration with round cells, and to dilatation of the blood-vessels. The glands penetrate into the muscular layer. When this consid- erable development of glands takes place the condition is sometimes designated as benign adenoma, as opposed to malignant adenoma, which is beginning cancer of the mucous membrane. The fungoid growths on the inside of the uterus are sometimes almost exclu- sively formed by glands ; in others they consist of round cells like the granula- tions on a wound ; and in a third variety they are almost entirely composed of di- lated blood-vessels. In some places the formation of connective tissue gets the upper hand," and the glands become atrophic or disap])ear. A similar difference is observed on different parts of the meml)rane, if it remains com])aratively smooth. The so-called erosions are due to a change in the epithelium cov- ering the vaginal portion, which normally is Hat like that of tiie vagina, but becomes columnar. In the interior is found an infiltra- tion with round cells, as in all inflammations. By invagination the epithelium forms follicles and tubules, which constitute new glands and, when they become closed, are transformed into cysts. Etiology. — Many pointjj have already been discussed in the cha])ter on Etiology in General (pp. 129-133), and the reader is referred to what is stated there about hyperemia of the pelvic organs, con- stipation, exposure to cold, improper dress, neglect during men- struation, certain abnormalities in regard to coition, puerperal in- fection, and abortion. The influence of gonorrhea has been spoken of on pp. 133 and 310, and we have seen how it may cause acute metritis (j). 424), but after the acute stage is over it may remain as a chronic inflam- mation. During childbirth the cervix, and especially its mucous membrane, is subjected to such pressure and abrasions that often a chronic endo- Intra-uterine polypi (De Sindty) DISEASES OF THE UTERUS. 429 cervicitis follows. This is especially the case if the cervical portion is torn (p. 415). Parts or the whole of the decidua may remain after childbirth and abortion and continue to live as part of the endometrium, a condition that has been described as decidual endometritis. Old age gives rise to a peculiar form of endometritis called atrophic endometritis. The normal columnar epithelium becomes changed to an irregular horny one, more like the flat epithelium of the vagina. There is a profuse purulent discharge. Sometimes the opposite walls grow together, especially at the internal os, which gives rise to senile pyometra. Whether bacteria play any role in chronic metritis is yet unsettled. Symptoms. — A prominent symptom is pain. In the general divi- sion of this book we have enumerated the order of frequency with which a neuralgic pain is found in certain localities (p. 136). Besides, the patient, as a rule, complains of " bearing down," a disagreeable sensation of heaviness extending from the interior of the pelvis to the external genitals, and often of " cramps," a painful feeling of muscu- lar contraction of the uterus caused by retention of blood or mucus above the internal os. Sometimes, although the ophthalmologist finds no fault in her eyes, she complains of pricking pains in them, of weak eyesight and photophobia, often combined with pain in the occiput, where tiie visual centers are located. It is not rare that a feeling of discomfort necessitates frequent mic- turition although the urine is normal, a condition designated as irritable bladder. As a rule, the menstrual discharge is preceded and accompanied by more or less severe dysmenorrhea ({). 259). Secondly, abnormal loss of bkxKl from the uterus is of frequent (K'currence, and easily explained by the vascular development de- scribed in the paragraph on morbid anatomy. There may be men- orrhagia (p. 202) or metrorrhagia (p. 204), or both, and often pro- tracted menstruation, tiie menstrual process extending over an uiuisual number of days, although ])erliaps the total loss of blood does not exceed the normal (juantity. When loss of blood is a prominent feature the condition has been described as Iicniorrliaf/ic cvdoiiidritis. In very Mcak patients endometritis is, on the other hand, occa- sionally accompanied by amenorrhea. A third symptom that brings the patient to seek help is leucorrhca, which is easily accounted for l)y the liyper})lasia of the normal glands and the constant formation of new ones. The fluid secreted by the cervix is like raw white of an egg (p. 208), that from the inteiior of tiie body is more; milky. I>oth are alkaline, and both may become pMnilent, which is es|)eci;illy the ease in g(»norrlieal and atrophic endf)metritis. As to the microscoj)ical composition, see p. 2()S. Ff the discharge is at all abundant, it weakens the constitution (p. 20(»). 430 DISEASES OF WOMEN. When leucorrhea predominates, the disease has been called catarrhal endometritis or catarrh of the uterus. In some patients there is a very free discharge of a mnco-serous fluid, a condition called hydrorrhea. At times the secretion may he retained above the internal os, probably on account of the swelling of the mucous membrane or a spasmodic contraction of the surround- ing muscular tissue. The uterus may then become quite distended, and the patient has considerable pain until the obstacle gives way, and the accumulated fluid rusiies out in a gush, when she feels relieved until the same process repeats itself. Apart from pregnancy hydror- rhea is a rare disease.^ The hydrorrhea of pregnancy, hydrorrhea gravidarum, on the con- trary, is rather common. Watery fluid may be discharged any time during pregnancy, but it is most common during the last month of gestation, and often gives rise to the erroneous supposition that the " waters have broken." A similar condition is sometimes found after childbirth — puer- peral hydrorrhea. It is then commonly due to the retention of a portion of the placenta or of clots, but a polypus may produce like results." The patient afflicted with endometritis loses her appetite, and suf- fers often from nausea, dyspepsia, and constipation. She becomes weak and pale, with black rings under her eyes. Some patients complain of a feeling of oppression in breathing. Some have palpitations. The nervous system suffers much. These patients are quite fre- quently despondent and melancholy. I have seen cases of acute mania and epilepsy. Hysteria is not more frequent in those affxH'ted with endometritis than in others ; it is, therefore, doubtful if there is a causative relation between the two. An inflamed endometrium does not seem to be a favorable ground for the implantation and development of the ovum. The abundant leuchorrhea helps also perhaps to expel it. So nuieh is sure that ])atients afflicted with endometritis often are sterile, or if they con- ceive they have a tendency to abortion. It is also claimed that pla- centa prsevia may be caused by it, the ovum sinking down to the os internum before it becomes fastened to the endometrium. By vaginal examination we find, in most cases, at least in women who have borne children, the os patulous, velvety, or granular, often studded with small, round, hard bodies {ovula of Nabotli). In nul- ' I have seen a case in which the uterus was purple, slightly tender, and meiis- ured, when the patient consulted me, 2>\ inches, but before that it had been as inncli as 5 inches, as measured by other gynecologists of this city. Iler discliargc was so copious that " she used forty diapers a day, that it wetted sheets, and that she could pass it on a bed-pan and fill bottles with U." '■* R. Barnes, Disease-i of Women, London, 1873, p. 81. DISEASES OF THE UTERUS. -431 liparous women, on the other hand, the external os is often too nar- row, and the secretion accumulates in the cervix or in the body of the uterus or in both simultaneously. The cervix is quite commonly enlarged, either too soft, when the cellular infiltration, tiie formation of glands and cysts, and the dila- tation of the blood-vessels predominate, or too hard, when the hyper- plasia of connective tiasue has caused atrophy or disappearance of the softer structures. The uterus is tender on pressure. The introduction of the sound and dilator is unusually painful and often causes some bleeding. By moving the sound along the interior surface it is often felt to be rough or the seat of polypi. Diagnosis. — In lumbo-abdominal neuralgia certain parts of the uterus, especially on the level with the internal os may be tender on pressure, but then all the other symptoms, especially hemorrhage and leucorrhea, are absent. A jibrvid tumor often causes hemorrhage and leucorrhea, but the presence of the tumor can be made out by bimanual examination. If it is Q. fibroid polypus, it can be felt with the sound. The diagnosis from the early stage of cancer may be difficult. In cancer we find, however, such friability of the tissue that parts can be scraped off with the nail, or are spontaneously expelled from the inte- rior of the womb, which is never the case in endometritis. On the other hand, this soft tissue is surrounded by one that is much harder than in mere inflammation. Cancer is accompanied by a profuse discharge of a watery fluid or thin pus with a ])eculiar pungent and offensive o<lor. As to hemorrhage, when the patient is in the prime of life, has a subiuvoluted uterus, and suffers merely from menorrha- gia, the probability is in favor of hyj)erplastic cndometrits, and against malignant disea.se. On the other hand, bleeding after the menopause is a very suspicious symptom. Many lay much stress upon irregular bleeding in the intermenstrual periixl, especially after coition, but I have often seen this in cases of lacerated cervix with ectroj)ion. Pain is, as a rule, absent in beginning cancer, but sometimes the ])atient has vague shooting ])ains in the j)elvis. Cancerous tissue is well differenti- ated from the surroundings, forming a glistening j)rominence not unliUe currant jelly. The effect of treatment will soon dispel all doubt. The diagnosis is made sure by cutting out a piece of the suspicious tissue from the cervix, imbedding it and preparing microscopical specimens of it. In the same way the malignant or benign nature of scrapings from the interior of the womb is ascertained. Mere *'tea.sing" with two neetUes does not furnish conclusive s|)ecimens. Prognosis. — Ciironic endometritis is at best a very tedious dise:u-;c, and it is not safe to promise more than improvement. This applies particularly to the catarrhal discharge. l]ut even this is sometimes 432 DISEASES OF WOMEN. completely cured. As to conception, the prognosis should be still more reserved, especially in cases of catarrhal endometritis involving the body of the womb. Hemorrhage may undermine the constitution and even prove fatal, but in this respect our therapeutic resources are manifold and powerful. As to pain and other nervous phenomena, the outlook is favorable. Treatment. — What pro])hylactic measures are to be taken, is self- evident by reference to the above paragraph on etiology. Here we will only notice the importance of removing the endometrium with a curette after abortion, and of not allowing pieces of placenta or mem- brane to stay behind after delivery. In patients aifected with gonorrhea of the urethra and vagina, the extension of the disease to the uterus may perhaps be prevented by the use of a tampon soaked in the following solution :' ^. Acidi tannici, lodoformi, ad 3ii ; Glycerini, 5v. — M. Patients affected with chronic endometritis need a good deal of rest. Gymnastics, dancing, bicycling, machine-sewing, and similar fatiguing movements, make their condition worse. Moderate exercise in the open air is good, but the patient ought never to walk so much as to increase her pain. In order to avoid pelvic congestion, she should abstain as much as possible from sexual intercourse. For the same reason the bowels should be kept open if she is constipated (p. 241). An elastic belt surrounding the whole abdomen (p. 198) is often useful in stout women by shifting over on the spinal column and the lower extremities some of the pressure exercised on the uterus by the intestines and other abdominal organs. A warm bath (p. 195) twice a Meek has often a very soothing effect on the nerves, and probably withdraws blood from the uterus by dilat- ing the capillaries of the skin. Warm sitz-baths have a similar effect. By the use of the bath-speculum (p. 195) this may still be enhanced. Sea-bat]iing, shower-, sponge-, sheet-, or towel-baths, or a regular hydrotherapeutic treatment is excellent in combating catarrh, hemorrhage, and debility. Certain spas (p. 1 96) have a repu- tation for being beneficial in chronic endometritis. The disease being of long duration, we should use anodynes (p. 243) very sparingly. Backache is temporarily relieved by rub- bing the region with a mixture of 1 part of chloroform with 3 parts of olive oil four times a day. The pain in the eyeballs accompanying asthenopia disappears rapidly under the use of a douche of cold water directed three times a day for five minutes against the closed eyes. ^ H. Fritsch in Billroth' s und Luecke's Handb. d. Frauenhr., vol. i. p. 1043. DISEASES OF THE UTERUS. 433 Certain fountain-syringes are accompanied by a nozzle in the shape of the rose of a watering-pot, which answers the purpose. With this treatment I combine, as a rule, scarification of the cervical portion and the administration of tonics (p. 242). For irritable bladder I use the following mixture : ^i. Tinct. belladonnse, Sij ; Liq. potassse, ^j ; Aquam, ad siv. M. Sig. 1 teaspoonful in a wineglassful of water 3 times a day, l)etween meals, or, if the urine is alkaline, a tablespoonful of the saturated solution of boric acid four times a day. In regard to hemorrhage the reader is referred to what has been said on p. 263. If the measures described there fail to check the uterine hemor- rhage, the uterine artery may be ligated on both sides (p. 187). Sometimes salpingo-oophorectomy has been performed, and even hysterectomy. If in hyperplastic endometritis the endometrium is studded with prominences, curetting (p. 180) has a prompt effect. If the whole membrane is swollen, the intra-uterine chemical galvano-cauterization according to Apostoli's method is excellent. The galvano-cautery has also been used for this purpose, but is probably an unnecessarily harsh treatment. The treatment of amenorrhea is discussed on p. 257. It occurs sometimes for from one to four months after curetting, and should then not be interfered with, as it is a beneficent pause after the drain on the system for whieii the curetting was done. For the treatment of lencorrhea directions are found on ]). 2G9. Since we have seen above how llie glands of the mucous membrane become enlarged and dij) into the niu.-cular layer, it is easy to under- stand how fruitless often all applications pi'ove, and how important it is to combine general with local trcatnicnt. Curetting, chemical irritants, the actual cautery, and other powerful revulsives, work not only by removing diseased tissue, but the tissue is returned to a niedullaiy state, and taking a new start the new-formed tissue may bec(»me healthy. Oppression and ))alpit:itions are treated with bromides, especially monobromated camphor (gr. i-x, (. i. d, in emulsion oi- capsules). Ovula Xahothi an; pricked ojx'n and then painted with tincture of io<lino. Exce})tionally, the whole cervical portion may be one ngsxlom- eration ot" cvsts, which do not yield to this ti'eatiiient. Then tluy should gradually be destroyed with a needle-shaped l*a(juelin's cau- terv or galvano-caut<'rv, or the cervical portion am])ntatcd (see Chroni(; Parenchymatous Metritis). For erosions tln-rc is no better treatment than to bathe the vaginal 28 434 DISEASES OF WOMEN. jK)rtion iu a tubuliform speculum for a couple of minutes with acidum pyroliguosum rectifieatum twice a week ; but this substance has such a pungent odor that it is disagreeable to most people. A 10 per cent, solution of sulphate of copper ai)plied in a similar way for a few min- utes two or three times a week is also very good. Erosions may also be treated with carbolic, chromic, or nitric acid, followed by a solution of bicarbonate of soda in order to neutralize the superfluous acid. Injections of chloride of zinc, chloride or subsulphate of iron, and nitrate of silver are also valuable. I often combine curetting by means of Simon's sharp spoon with the application of licpior ferri chloridi. I have obtained excellent results by applying to the eroded os, through Cusco's speculum, the positive j)ole of a galvanic battery iu the shape of a ball of gas-carbon wound with very little cotton, squeezed nearly dry. It is used for five minutes with as strong a current as the patient can stand (about 40 milliamperes). It leaves an eschar followed by suppuration. A few such applications re- peated once a week produce a healthy mucous membrane in shorter time than any astringent. Apostoli has constructed a special elec- trode for the pur])ose (p. 251). If the cervix is lacerated, trachelorrhaphy should be performed (p. 418), or, in very bad cases, the cervix may be amputated. In the interior of the body of the uterus the above-named acids and astringents are also used. The substances I personally use for treating the endometrium are Churchill's tincture of iodine, chloride of zinc, nitrate of silver, and chloride of iron, and I a})})ly them all on absorbent cotton wound around my applicator (p. 174). Iodine is the mildest and the most generally useful, especially indi- cated if the discharge is purulent ; chloride of iron is best in the hem- orrhagic, chloride of zinc and nitrate of silver in the catarrhal form. Besides the intra-uterine a})j)lication, I paint the vaginal roof with tincture of iodine (p. 175), which probably acts as a counter-irritant. The patient herself introduces a j)ledget with glycerin, with or without ichtliyol, morning and evening (p. 182). As we want the iodine to enter the tissue' by endosmosis, and glycerin causes a powerful exosmosis, it is better not to introduce the pledget imme- diately after painting the vagina. As an astringent on a s})ongy cervix, glvcerite of tannin is very good (p. 183). Duke recommends boracic acid in powder applied with a tube and piston (p. 175). Scarification is used not only for opening and destroying cervical cysts, but also to give exit to some blood. When the uterus appears congested this procedure often gives great relief (p. 194). If the external os is too narrow, mucus often accunuilates in the cervix, which is distended in the shape of a barrel. In such cases DISEASES OF THE UTERUS. 435 the treatment must begin by gradual dilatation of the cervical canal (p. 156). If the OS is so small that not even a common uterine sound can enter, it is necessary fii'st to make a little nick with a knife. In chronic endometritis of gonorrheal origin the treatment is sim- ilar to that in the later stage of the acute (p. 425). In cases of catarrhal endometritis that had resisted all other treatment the writer has obtained a cure by cutting off the wliole mucous membrane of the cervix, and leaving the wound to heal over an intra-utenne glass stem. Exfoliating Endometritis. — Exfoliating endometritis, also called menstrual endometritis, or monhmnov.'i difsmenorrhca, is a rare variety of endometritis that presents such peculiar features that we are obliged to treat it separately. It forms a link between acute and chronic endometritis in so far as it is an acute process that repeats itself every four weeks. Pathological Anatomy. — The nuicous membrane of the b(xly of the womb is swollen and red. It is thrown oif in shreds an inch in diameter or even as one piece representing a cast of the uterine cavity with an inner smooth and outer rough surface and three openings corresponding to the internal os and tlie apertures of the Fallopian tubes. Microscopical examination shows that the uterine glands are un- changed, but that there is great hyperplasia of the cells of the endo- metrium, which retain their normal size, but are pacivcd so closely together that little space is left for tlie inter-cellular substance. Etiology. — Exfoliating endometritis is a form of chronic endometri- tis. It is sometimes allied to fibroids, and occurs in women affected with syphilis, tuberculosis, or suffering from acute ])liosphorus- poisoning. Symptoms. — The disease is characterized by severe pain in the pelvis recurring at eacli menstrual ])eri()d and followed l>y the expul- sion of the above described parts of the endometrium. It may be found at any age during menstrual life. Persons affected with it may become pregnant, and arc liable to abortion, but may even give birth to children and then again he affected in the old way. Diagnosis. — Exfoliating endometritis is, as we have said, a very rare disease, and assertions to the contrary arc based on errors of diagnosis. A chief point in the diagnosis is the regularity of the exj)ulsion of membranes, but even that may Ik; sinuilated for some time by regu- larly repeated abortions. TIk; microscope alone can positively settle th(! diagnosis. The j)resence of villi choi-ii is absolute proof that the specimen is a jnoduct of conception, and even the decidna of preg- naiKT dilfers from that of meiistiiiatioii i)v the lai'ge size of the cells of the endometrium. In ecto])ic gestation a similar ex|)ulsion of the endoiiictriiiiu inav take place. In order to a\-oid cri'ors as nuich as possible, the pel- 436 DISEASES OF WOMEN. vis must be examined most carefully for a tumor that* might be the fetal sac, aud all sigus of pregnancy, genital, pelvic, abdominal, sto- machic, mammary, cutaneous, and nervous, looked for. Treatment. — Spontaneous cures are reported, but, as a rule, the inter- vention of the healing art is solicited. The endometrium should be destroyed so as to give a chance for a new aud better growth. This is done by the curette followed by the application of tincture of iodine or iodoform pencils, or by the galvano-chemical cauterization accord- ing to Apostoli's method. 2. Chronic Parenchymatous Metritis. — Pathological Anatomy. — The size and weight of the uterus are increased, the wall is thicker, the cavity larger, and the tissue harder. Microscopical examination shows that the muscular bundles are separated by much broader layers of connective tissue than in the normal uterus. The walls of the arteries in the muscular tissue of the uterus are thickened and par- tially changed to connective tissue. The lymph-vessels are enlarged, and the peritoneal covering thickened. If the case is due to subin- volution after childbirth or abortion, the muscular fibers are found enlarged and abnormally numerous (hypertrophy and hyperplasia).^ Etiology. — The parenchymatous metritis may arise by extension from chronic endometritis. Frequent attacks of acute metritis may finally lead to the chronic form. It may be due to exposure to cold, especially living in a cold climate and in a damp basement. Too frequent coition and still more a connection that is interrupted without ending in orgasm and the normal sensation of contact with the ejaculatod semen, abortion, subinvolution after childbirth, and too rapidly recurring pregnancies, favor its development. It frequently accompanies displacements, — especially retroflexions, — fibroids, and cancer of the uterus, as well as ovarian tumors. Symptoms. — As a rule, the patient has no fever, but occasionally a rise of temperature up to 102° Fahrenheit shows an acute exacerbation in the chronic condition. She has an unpleasant bearing-down sensa- tion, often combined with pain in the groins and backache. jSIcu- struation is usually more ,or less painful. Quite often the patient feels an irritation of the bladder, compelling her to empty that organ frequently, although the composition of the urine is normal. Con- stipation is very common. Hysteria is not found oftcner than in other women, and is, there- fore, probably independent of the disease. Menorrhagia and leucorrhea are very common. Nervous reflexes, such as swelling of the breasts, mastodynia, and intercostal neuralgia, accompany it frequently. The dilatation and growth of the uterus during pregnancy is ac- companied by pain, and is often interrupted by abortion. ' Welch of Baltimore, quoted by A. P. Dudley, N. Y., Med. Jour., Sept. 4, 1886. DISEASES OF THE UTERUS. 437 Some patients have, in the middle of the interval between two periods, a so-called intermenstrual pain, much like that occurring with menstruation, but of shorter duration, and sometimes accom- panied by the excretion of bloody mucus. Vaginal examination reveals the enlargement and tenderness of the body of the uterus, and often a thickened, hard, eroded, and granular vaginal portion. In nervous and anemic persons a tumor is sometimes felt in one of the edges of the uterus at the junction of the neck and the body. It may become as large as a hen's egg. It is semiglobulai", of the consistency of a myoma, and sensitive on pressure. It is only con- gestive, is formed during hemorrhage, and disappears when the bleed- ing stops. After the bleeding follows an offensive discharge like lochia. These tumors have been described by French authors under the name of "tumeurs JInxionnaires," and are supposed to be due to metritis. Diagnosis. — Cancer of the body of the womb causes greater hard- ness, forms a tumor that can be felt, and is accompanied by a thin, purulent, malodorous discharge. By means of the sound the inner surface of the womb may be found to be irregular and to contain spots where the tissue is unusually soft. Prognosis. — Chronic ])arenchymatous metritis does not, as a rule, threaten the patient's life unless the hemorrhages should be profuse enough to undermine her constitution, but it is an exceedingly tedious disease, sometimes extending over many years, and a perfect cure is rare, although much can be done to alleviate the sufferings of the patient. Treatmait. — In order to avoid needless repetition, the reader is referred to what has just been said about chronic endometritis, which always accomj)ani(s the parenchymatous form. Here we will only add measures ])articularly indicated where the muscular coat of the uterus is implicated. Among internal medicines, a long-continued use of small doses of chloride of gold, or o^ corrosive siihliraate (p. 244) may succeed here as in other parts of the bo<ly in reducing the abnormal deposit of con- nective tiasue. In cases of subinvolution, Tait ])raises the effect of chlorate of j)otassiuni, gr. viiss, t. i. d., given in a medicine with a few drops of dihite hydrochloric acid. Faradizafioii has a siniihu* effect l)y causing muscular contraction. The bij)olar intni-utcrine nicthtKl (p. 24(5) is particularly recom- mendable. Apostoli praises the primary current. The galraiiic ciirmit (p. 2 Hi) may hclj) to rcihice the bulk of the uterus by electrolysis. Massage (p. 195)) causes al)sorption by mechanical manipulations. Finallv, o{)erative interference not only serves to remove redinidant 438 DISEASES OF WOMEN. tissue luechauieally, but oxpcrionce has showu that it so modifies the nutrition of the womb that that organ may shrink considerably in the course of several montiis following the operation. If the cervix is lacerated, trachelorrhaphy (p. 418) should be performed. If it is not torn, but much enlarged, it may be diminished in diiferent ways. 1. Gordon's Method} — If the cerviail canal is so hirge that it can be done without causing stenosis, a wedge-shaped piece may be cut out, having the base at tiie os and the apex at or somewhat beyond the utero-vagiual junction. This operation is performed exactly like trachelorrhaphy, and recommends itself by its safety and simplicity and by leaving a normal vaginal portion, which may be needed for the adaptation of a pessary. 2. Hegar's Method consists in the removal of the whole vaginal portion. The patient being in dorsal decubitus, the vaginal portion is exposed by means of a single Sims speculum (p. 147) and side retractors (p. 227), and the uterus pushed and pulled down. The cervical portion is split open with scissors on both sides up to the vaginal vault. Each lip is seized with a volsella or bullet- forceps and cut oil* with scissors bent at right angles. In dealing with the anterior lip the operator must take care not to go beyond the boundary-line of the bladder, which may be ascertained by means of a metal catheter. Next, the mucous membrane of the cervical canal is united by a row of sutures to that of the vagina, comprising part of the cut surface, but skipping that part which is farthest away from the mucous membranes (Fig. 254). Sometimes it Fig. 254. Hegar's Amputation of the Cervical Portion : a. two sutures on each side do not enter the cer- vical canal : b, all sutures are passed from the vaginal to the cervical mucous membrane. In both cases a portion of the cut surface is skipped in inserting the sutures. is better only to do this in the middle, and to unite the vaginal mucous membrane in front and behind at the sides. This is done with rather ' S. C. Gordon of Portland, Me., Amer. Jour. Obst., 1884, vol. xvii. p. 1205. DISEASES OF THE UTERUS. 439 Simon's Cone-mantle-shaped Excision of the Vaginal Portion: a, sutures inserted ; 6, sutures tied. (There ought to be one or two on each lateral incision). strong, curved, round, cre.scent-ground, or trocar-pointed needles or the fishhook-shaped needles (Fig. 201,/, g, and /), held in a needle- holder.' Fig. 25(5. A B C Schroeder's Pinple-flnp Excisidn of the Vaginal Portion : A, excision made, sutures placed on anterior lip aii<l tic<l mi posterior; 1 and 2, lateral sutures. 1$, longitudinal scciiun through cervix: i^/ r, transverse incision :/ e, longitudinal incision joining the first and severing the mucous membrane ami part of the muscular tissm? from the cervix; h c, course of a suture ; f/, f)vula of Naboth. C, longitudinal section after the sutures are tied. 3. tShnon\'i Mffhnd, the so-called conc-mnnflr-sjiaped excision. — After having made the two lateral incisions a wcdgc-.shapc<l piece is cut out with a knife <tf the whole width of each lip from side (o side, ' My traclielorrliapliy needles (p. 418) are cjuite servicciible in this o|)cr:iti<ii). 440 DISEASES OF WOMEN. Next, the two flaps of eacii lip are united by sutures, and, finally, the two lateral incisions are similarly closed (Fig. 255). This method is especially indicated when the cervix is very thick and hard and the mu(!Ous membrane of the cervical canal healthy. 4. Schroeder's Method. — The same lateral incisions as in the other methods are used, but then the whole mucous membrane of each lip with part of the muscular tissue is cut away. For this purpose a transveree incision is made through the mucous membrane of the cer- vix at the base of each lip, and then a wedge-shaj)ed piece is cut off from the os to the first incision. Each of tlie lips is folded trans- versely, and the lower end of the cut surface united to the upper. Finally, the side incisions are closed (Fig. 256). This method is more difficult to perform, but is preferable when the cervical mem- brane is in a bad condition. The removal by means of the galvano-caustic snare is less a})pro- priate than the cutting operations, since it necessitates the healing of the wound by granulation and may lead to steno.-is of the cervical canal. If there is leucorrhea, menorrhagia, or metrorrhagia, it is proper to combine curetting with the amputation. If chronic parenchymatous metritis gives rise to persistent hem- orrhage, salpingo-obphorectomy may be performed ; and if that does not suffice to arrest the loss of blood, the uterus may have to be removed by vaginal hysterectomy. CHAPTER V. Closure of the Uterus (Acquired Atresia). In the description of malformations we have seen that atresia of the uterus may be congenital (p. 410), but the uterus may also become closed later in life — acquired atresia. Althougli not so rare as the congenital form, the acquired is still a rare affection. The closure is most common at the external os, after that at the internal os, but more or less of the whole cervical canal may be closed. Etiology. — This condition may be brought about by adhesions forming after childbirth or abortion, cauterization with strong acids or nitrate of silver, the red-hot iron, or the galvano-caustic apparatus (p. 251). Ulceration of the cervix, diphtheria, small-pox, and scarlet lever may lead to it. Sometimes it is simply due to old age, and is especially found in old women suffering from prolapse of the uterus. Symptoms. — In menstruating women the acquired closure gives rise to symptoms similar to those of the congenital closure, such as DISEASES OF THE UTERUS. 441 amenorrhea, abdominal pain, menstrual molimina, and swelling of the uterus in consequence of accumulation of blood {hematometrci), mucus (hydromdra), or pus (pyometra). If the contents of the uterus become decomposed and gases are formed, the condition is called phy- sometra. Under these circumstances the percussion sound becomes tympanitic, whereas otherwise it is dull. After the menopause the atresia hardly giv^es rise to any symptoms, unless it is complicated with some other disease of tiie womb, espe- cially cancer or fibroma. The size of the womb in hydrometra hardly surpasses that of a fist. The walls are distended and sometimes thinner than in the nor- mal condition. If the closure is at the external os, the cervix and the body form together one globular tumor. The course is chronic. Sometimes the disease, especially in physo- raetra, terminates spontaneously, the obstruction in the cervix giving way and the gas escaping. Treatment. — The cervix should be perforated with a curved trocar and then cut in four different directions with Simpson's metrotome (Fig. 258). The uterine cavity should be washed out with an anti- septic fluid, and packed with iodoform gauze (p. 184), followed by an intra-uterine glass stem (p. 411). Jn regard to the dangers of the operation, the reader is referred to what has been said in speak- ing of atresia in other parts of the genital canal (p. 346). CHAPTER VI. Stenosis of the Cervix. Stenosis, or narrowness, of the cervical canal is somewhat similar to atresia, but tiie difference is that the cervical canal is o])en, although the caliber is too small. IJke atresia it may be congenital or acquired. It is often combined with a conical cervi.T, which may be hyper- trophic, of normal dimensions, or atrophic. It accompanies also dis- placements, especially anteflexion. It is most common at the external os, which forms a round ojien- ing, sometimes so narrow that it does not even admit the common uterine sound ( pinJiole ox). Less freciuently it is found at the inter- nal OS. Sometime,s the whole cervical canal from end to end takes part in the stenosis, but in other c«.ses it is, on the contrary, dilated between the two narrow openings so as to form a l)arrel-shai)ed cavity. The etiology of the acfjuin-d form is identical with tiiat of atresia. f^ymptom.s. — If the menstrual l)loo<l is secreted in larger amomit than what can jkiss in the same linu' through the nan-ow cervix, the patient has ])ain [oh.sfnicfirr ihismcnorrhea). Often the blood coagu- 442 DISEASES OF WOMEN. lates, and the clots are expelled with })ainful cramps. Also mucus may stagnate in the cervix or the body and give rise to bearing-down pain, relieved from time to time by the expulsion of the accumulated fluid. Sometimes all the symptoms of chronic endometritis and parenchymatous metritis (pp. 429 and 43G) are developed. Some women are, however, in excellent health in spite of their stenosis, and they consult us only on account of sterility. Although pregnancy may take place when there is only the smallest opening admitting the spermatozoids, it is indisputable that a narrow cervical canal is a great impediment to conception. Diagnosis. — The stenosis of the external os can be felt by a prac- tised finger and is seen by means of the speculum. That of the internal os can only be inferred from the difficulty with which the sound passes. The beginner must, therefore, be on his guard, as he will find many cases of stenosis of the internal os, which in my ex- perience is by no means common. The normal opening is only ^ inch (p. 49), and it is tight enough to be distinctly felt as a yielding obstruction, when the knob of the uterine sound passes it. Before diagnosticating a stenosis of it, the physician must make sure that the end of the sound is not caught between the folds of the plicae palmatse or arrested by a flexion. For this purpose it must be intro- duced in all directions and with different degrees of curvature. The best proof that a stenosis really exists is that the common sound is arrested while a thinner probe passes. Treatment. — Stenosis used to be treated with incision, either bilat- erally or in the median line of the posterior lip. The cervical por- tion was split open up to the vaginal junction with Kiichenmeister's scissors (Fig. 257), that have a blunt and longer blade for entering Fig. 257. Kiichenmeister's Scissors. the cervix and a shorter blade ending in a sharp hook, which prevents the scissors from sliding. Besides, the incision was carried more or less up to or through the internal os with Sims's uterine knife. For cutting the internal os and more or less of the whole cervix Simpson's DISEASES OF THE UTERUS. 443 metrotome (Fig. 258) was used, a sheathed knife, the excursion of which is regulated by a screw, and which cuts in one direction at a time, or Greenhafgh^s metrotome, that cuts both sides at the same time. When it was found tiiat this deep cutting not infrequently was accom- panied by dangerous or fatal hemorrhage or by not less dangerous Fig. 258. Simpson's Metrotome. and fatal pelvic septic inflannnation, superficial trachelotomy was sub- stituted.^ Cutting for stenosis has in a great measure been replaced by dilatation. I make only a very small nick at the external os, if it is necessary for the introduction of the sound. I also cut out a wedge-shaped piece of the cervix, if the os besides being too nar- row is situated excentrically. There is no hemorrhage, and inflam- mation is avoided by the use of antiseptic precautions (p. 209). In most other cases I only use dilatation with blunt conical and diverging instruments (p. 158), which is much safer than any degree of incision or the use of tents. I have, indeed, never seen any trou- ble arise from rapid dilatation. In most cases I treat the })atient in the office twice a week. I use first the lower numbers of Hanks's dilators, and then my own diverging dilator up to one-half inch ex- pansion. I never go farther in one sitting than that the patient can stand the pain without an anesthetic. In more exceptional cases I operate in the patient's house, etherize her, use the strictest antiseptic precautions, and o})en the dilator to full expansion, one and a quarter inches in all directions. In order to avoid tearing the tissues tiiis must be done very slowly and gradually. I introduce some iodoform into the cervix, and cover it with iodoform gauze. The ])atient is kept in bed for foin- days. A glass stem (see chapter on Flexions) is placed in the cervical canal while it is contracting. The canal of the cervix may also be enlarged by means of electro- lysis. For this piu'pose the galvanic; current is to be used with the negative pole in the uterus, the positive on the abdomen. For the latter I have used Fiigchuaini's electHnle (p. 248), for the former Fry'sj which has six nickel-plated conical ti|)s, ranging from 11 to 25 millimeters in circumference, to be screwed on tli<' same iiaiidle. I have, however, not found any advantage in tiie electric treatment over the mechanical. ' IVaslee, Amcr. Joum. ObM., 1870, vol. ix. ji. 374. 444 DISEASES OF WOMEN. CHAPTER VII. Ulcers of Cervix. AVe have mentioned, in treating of chronic endometritis (p. 408) that the term ulcer is often erroneonsly applied to eroHio7is and gran- ulations of the cervix. But the cervix may be the seat of true ulceration — i. e. an inflannnatory process in whicli there is molecular loss of substance. Such ulcers may be chancroids, chancres, tubercu- lar idcers, simple vJcers, or corroding ulcers. Chancroids have been described on p. 291 and chancres on p. 293, tuberculous ulcers p. 288 and p. 363, in treating of the diseases of the vulva and the vagina. Simple idceration takes ])lace Avhen the cervix protrudes through the vulva, be it in consequence of hypertrophy or prolapse. It is due to friction against the clothes. There is a flat more or less irregular loss of substancic surroHuding the os, or what seems to be it, if the case is complicated with bilateral laceration of the cervix. The surround- ings have a blue or purple color and are harder than normal. With proper treatment these ulcers heal easily. If they accompany simple hypertrophy, the cervix is amputated and no treatment directed to the ulcer. If the uterus is jn-olapsed, it should be replaced, kept inside the vagina by a perineal bandage, and the wound covered with a piece of lint smeared with the ointment of iodoform and balsam of Peru (p. 266), to be changed morning and evening. Corroding ulcer looks mucii like a cancerous ulcer, and is destruc- tive in character. It may open into the bladder, but on microscopical examination no epithelial elements are found. It seems to be due to senile gangrene induced by calcification of the internal iliac artery.^ The diagnosis can only be made by means of the microscope. The treatment is the same as for cancer, especially total extirpation before the formation of a fistula. For ulcerated cancer, see Chapter XIIL, Sarcoma and Carcinoma. CHAPTER VIII. Hypertrophy of the Uterus. An increased size of the uterus, apart from neoplasms, is com- monly due to subinvolution or chronic metritis (p. 436) ; but it may be due to sim])le hypertrophy, independent of all inflanmiatory action. The uterus presents abnormally large dimensions, but there is no change in structure. This hyi)ertrophy may be general or partial. ^ John Williams, Trans. Obd. Soc. of London, vol. xxvii., reprint. DISEASES OF THE UTERUS. 445 General hypertrophy is a very exceptional condition. Partial hypertrophy has rarely its seat in the body. As a rule, then, it is the cervix that is the affected part. We distinguish between infravaginal and supravaginal hypertrophy.* A. — Infravaginal hypertrophy consists in an increase in size of the vaginal portion of the uterus, which, as a rule, takes place chiefly or exclusively from above downward, resulting in an elongated cervix. This hypertrophy may be congenital (p. 406) or acquired, and the condition differs somewhat in the two classes. The congenitally hypertrophied cervix is only elongated, cylindrical, or conical, sometimes trunk-shaped in consequence of the greater development of one of the lips, mostly the posterior, or more rarely club-shaped. The os is round, of normal size, or too narrow. The elongation may be slight or so considerable that the cervix protrudes penis-like from the vulva. In the acquired form of hyi)ertrophy the cervix is commonly not only elongated, but thickened, and it is frequently thicker near the end than at the base, forming a club- or cabbage-sliaped mass. The OS is large and forms a transverse slit. Very often the cervix has sustained bilateral laceration (p. 415), and frequently the condition is combined with prola])se of the uterus, but in these two classes of cases I think we have to deal with chronic metritis, and no longer pure hypertrophy. The acquired form is exclusively found in women who have borne many children. Etiology. — The cause of the congenital hy})ertrophy is unknown. The acquired is evidently due to childbirth. HymjdonuH. — Sometimes hypertrophy of the cervical portion does not give rise to any symptoms. In other cases the patient eomj)lains of a bearing-down sensation and discomfort in walking or sitting down. Sometimes she has considerable dysmenorrhea, but this is probably due to the accompanying stenosis of the os (p. 441). The friction against the vaginal walls may cause leueorrhea. When the cervix })rotrudes from tlic vulva it is liable to become ulcerated (p. 444). li' the hvjK'rtrophy is pronounced, it gives rise to dys- pareunia, the male nuimlxT meeting Avith an obstruction, which is pushed forward, causing discomfort and even pain to the female, and sometimes to tlu; mah; too. The semen, being ejaculated into the deej) jMHich formwl beliind tlw; cervix, does not easily enter the os, and sterility is, therefore, (|uite common. I)itignos-is. — TIk' diagnosis is easy. By vaginal examination the finger may be carried round the hyj)ertroj)hied cervix, "^riie vaginal ' Schroeder has aiUlcl :is a tliinl catci^ory the hyportroj)liy of what Ik> calls the inlrrmiylinlf. jxirlloii ; tliat is, that |»art of the corvix that is hound to the hiaddcr in front, but has iH'hiiid the deep iionch fomii'd liy tlio posterior fornix of tiu' vatjina (p. 42 ; from a practical standpoint this variety may ho taken toirctiier with the Btipravjiginal. 440 DISEASES OF WOMEN. vault is found normal. The sound may enter from three to six inches, and yet bimanual examination finds the fundus uteri at its normal place. Prognosis. — The disease is chronic and has no tendency to retro- gression. In virgins, in whom the vaginal walls and the uterus have preserved their normal resiliency, an elongated cervix does not find room enough, but is pushed down in the direction of the outlet and serves as a lever to tip the uterus backward into the position called retro- vereion. Treatment. — Slight degrees of elongation may successfully be treated with dilatation (p. 156), which enlarges the os and shortens the canal. In more pronounced cases the redundant tissue must be removed by amputation. For simple elongation, Hegar's method (p. 438) is the best ; for hypertrophy with thickening of the cervix Simon's cone-mantle-shaped excision (p. 439) recommends itself. In order to control hemorrhage it is a good plan to surround the base with an elastic ligature. If feasible, this should even be placed above one or two needles perforating the cervical portion at right angles and preventing the ligature from slipping, or sewed to the cervix wath a few stitches. The common ecraseur has the fiult of having a ten- dency, w^hile being tightened, to pull in neighboring tissue, by which the peritoneal cavity or the bladder may be opened. The galvano-cautery, and the common cautery even more, expose to stenosis of the cervical canal (p. 441). B. Supravaginal hypertrophy consists in the increase, especially elongation, of that part of the cervix that is situated above the utero-vaginal junction. Pathological Anatomj/. — The supravaginal part of the cervix is felt as a long cylindrical body, somewhat flattened in the antero- posterior direction, and, as a rule, thinner than normal ; but excep- tionally it is of normal circumference or even thicker. The dimensions of the infravaginal portion and of the body are not much increased. In growing the cervix descends, and pulls the neighboring organs down with it. Thus the vaginal fornix sinks down. In front the pouch formed by it disappears entirely, while behind more or less of it still remains. The vagina becomes inverted. The bladder forms, as a rule, a swelling in front of the hypertrophied cervix (cystocele) ; Douglas's pouch descends with it behind, and sometimes there is a rectocele, but in many cases the rectum retains its place. The os uteri forms a large slit, and descends to or beyond the rima pudendi. The interior of the uterus measures from six to ten inches in depth, the increase coming nearly exclusively from the elongation of the upjier part of the cervix. Etiology. — This condition is due to prolapse of the vagina (p. 356). The body of the womb remaining in its place, and the cervix being DISEASES OF THE UTERUS. 447 pulled down, the latter is drawn out like a rubber tube. At the same time free circulation is impeded, the blood stagnates, and chronic metritis sets in, with formation of new cells, new connective tissue, and new muscle-fibers, rendering the total increase in bulk possible. Those conditions which promote prolapse of the vagina, such as laceration of tlie vaginal entrance, frequent childbirth, too early get- ting up after deliv^ery, subinvolution, occupations that keep the woman in a standing position, and vebereal excesses, lead indirectly to hyper- trophy of the supravaginal cervix. Symptoms. — The symptoms are like those of prolapse of the vagina and uterus, combined with those of infravaginal hypertrophy. The patient complains of bearing-down, backache, an uncomfortable sen- sation in the vagina, especially in walking and sitting down. She has often dysmenorrhea. She has frequent desire to micturate, and finds it often difficult to empty the bladder. She is constipated. The fric- tion in the vagina produces leucorrhea, especially in the posterior pouch. Connection is rendered unsatisfactory. That part of the mucous membrane that is turned out of the body becomes horny, like epidermis. The enlarged cervix is seen and felt, while the body of the uterus is felt above of nearly normal size, often antefiexed or retroflexed, and the infravaginal portion is not much elongated, if at all. Nearly always there are signs of bilateral laceration of the cervix, and the cervix participates in the inver- sion, so that the lips of the os uteri are situated far apart, and the inverted cervi(!al canal a})pears between them, more or less inflamed or even ulcerated (p. 444). Diagnosis. — A pohjpus and an inverted uterus have no opening at the lower end. In the itifr<iv<i(jiii(tl lii/pertrophy the vaginal vault is normal. The chief })oint in the diagnosis is the distinction from prolapse of the uterus, with which the supravaginal iiyj)ertroj)hy is often confounded ; but the fing('r-sha])ed mass formed by the cervix is easily felt by bimanual ])alpation with one finger in the rectum; the uterus is felt in its place; tiu; uterine cavity is much deeper than in simj)le prolaj)s(' ; a catheter introduced into the bladder is not felt from the rectum, tlie uterus intervening between the two canals. Frequently, however, the hyj)ertrophy is combined with j)rolapse. Prognosis. — Xo spontaneous cure is lo be expected. Tredtment. — In the lesser degrees the uterus may be pushed up, th(! body becoming strongly nuteverted, and nuich comfort may be afforded 1)V the use of a cujHshaped su])i)orter attached to an abdomi- nal belt. (See Pro/ojisr.) IT this j)l;iu does not su('ce(>d, i"eeours(! nnist be h;id to ;in oper:ition. 1. JI(t/iir''.-< Method, Fit ini< l-.^Jio jted I'lrrixioii (I'^ig. 209). — Dorsal ])Osture. The cervical ))ortion is e.\|)osed with a single Sims or (iarrigues speciilinn and latei'al retractors, seized with a \olsella, and pnlled (htwn. A circuhir incision is made below the ntero- 448 DISEASES OF WOMEN. vaginal junction. From this the knife is carried in a slanting direc- tion upward and inward to the cervical canal. When the canal has Fio. 259. Hegar's Funnel-shaped Excision of Supravaginal Cervix (natural size). been opened in front and the hemorrhage is considerable, a suture is passed immediately under the whole wound in the cervix, and so as to comprise the mucous membrane of the canal. If there is not much bleeding, the excision is continued from the sides and from behind with knife and scissors. The excised piece forms a cone, the length of which above the utero-vaginal junction may be 1^ to 1|- inches or more. The mucous membrane of the cervix is sutured all around to that of the vagina, passing the sutures with small, strongly curved needles under the whole wound — a procedure that is very difficult. It is, therefore, preferable to apply the thermo-cau- tery as soon as a part is cut, and continue alternating with the cut- ting and the searing instrument, or to do the whole operation wdth the galvanocaustic knife (see p. 450). 2. Schroeder^s Method (Fig. 260) is still more radical. A circular incision is made as in Hegar's. If vaginal arteries bleed, the hem- orrhage is checked with ligatures or clamps. Then the cervix is separated with the finger and blunt instruments in front and behind. Next it is pulled over to one side, and with a half-blunt aneurism- needle bent to the side (Fig. 269, p. 462) a ligature is carried around the tissue going to the side of the cervix and containing the blood- vessels. After having tied the ligature tightly and cut the tissue between the ligature and the cervix, another ligature is placed above the first. The other side is treated in the same way. When the cervix has been loosened sufficiently high up, the ante- rior wall is cut through to the cervical canal, and a deep suture is DISEASES OF THE UTERUS. 449 carried through the vaginal wall, the parametral connective tissue, and the severed cervical wall, and out through the cervical canal. If necessary to check hemorrhage, several such deep sutures are passed Fig. 260. A. Fig. 260, B. Schroeder's Supravaginal Amputation of Cervix. and tied before the posterior wall is severed. These sutures are left long, and serve to keep the uterus down. When the posterior part of the cervix has been cut, it is treated in the same way as the ante- rior, thus stitching the uterus all around to the vagina. If it happens that the ])eritoneal cavity is opened, the rent may be clo.sed separately with silk or catgut, or comprised in the sutures fixing the po.sterior cervical wall to the vagina. The vagina being much larger in circumference than the cervix, it forms folds and on the sides two gaps, through which the ligatures hang down. .'>. KcdfenbdcJi^s Method (Fig. 261). — After emptying the bladder and pushirig the intestines u|) from Doughis's pouch, the cervix is constricted at the vaginal entrance with an elastic ligature, which is stitched to tiie inverted vagina in front and behind, or the uterine artery is s<'cured on both sides (]). 188). A cireuhir incision is mad<', and the elongated supravaginal cervix is <'asily separated from the surrounding tissue with knile and scis.sors, and even partly with blunt instruments. A\'heii this has been done to the extent deemed iieees- .SJiry, .sometimes even above the internal os, the cervix is divideci with Kiichenmeister's scis.sors (p. 442) into an anterior and a ])osterior half, a transverse incision is made through the mucous meml)ran(! o(" each iialf, an inch from the lop, and the nnicous membrane; is dissected off, 29 450 DISEASES OF WOMEN. except at the top, about half an inch. Then the remainder of the cervix is cut off transversely at the base of the flaps. These flaps Fig. 261. Kaltenbach's Supravaginal Amputation of tlie Cervix. are stitched to the vaginal wall with three or four deej) sutures, coin- prising some of the muscular part of the stump. If we go too near the constrictor, the stumps of the cervix are apt to retract be- yond it. Next, a triangular piece is cut out on both sides of the collar formed by the receding vagina, and a couple of deep sutures are passed through the edges and around the vessels running on the side of tiie cervix, the base of the triangle being about a quarter of an inch from the outermost suture on either side and the top at the constrictor. This excision allows us to exercise tighter pressure on tiie ligated blood- vessels, and affords an excellent adaptation of the fornix to the stun) p. Finally, the contact between the edges of the two mucous mem- branes is perfected with a running suture of catgut. Then the con- strictor is removed, and if there is any bleeding, one or more deep sutures are inserted on the sides of the stump. This is the best of all the operations, in so far as it exposes less to hemorrhage and leaves a fine stum}). The amputation of a conical piece of the cervix, as in Hegar's opera- tion, may also be accomplished by means of the galvano-caustic knife or wire (p. 253). But even this does not prevent secondary hemorrhage, and is liable to cause stenosis of the cervical canal (p. 441). Tiie patient should, therefore, be carefully watched during the healing process. Besides primary and secondary hemorrhage, those methods of the DISEASES OF THE UTERUS. 451 supravaginal amputation which leave a large deep-seated, more or less anfractuous wound predispose to sepsis. 4. Vaginal Hysterectomy. — These drawbacks are avoided by removing the whole uterus, which may be done from the vagina or from the abdomen. The vaginal operation will be described below under Prolapse of tlie Uterus. 5. Abdominal Hysterectomy. — If the supravaginal hyi^ertrophy of the cervix is combined with such an hypertrophy of the body that the removal of the uterus through the vagina would be difficult, it may be undertaken through the abdominal wall, exactly as for a myomatous uterus. (See below, under Fibroid.) CHAPTER IX. Acquired Atrophy ; Superinvolution. Atrophy of the uterus may be congenital or acquired. We have described the congenital form above (pp. 411,412) as the fetal, the infantile, and the pubescent uterus. Acquired atrophy is a normal condition after the climacteric (p. 127), — senile atrophy, — but in consequence of the atrophy closure of the cervical canal, especially at the external or internal os, may occur and give rise to hydro- or pyometra (p. 441). The writer has also always found atrophy of the uterus in removing this organ after having previt)usly performed salpingo-oophorectomy on the same patients. Patliologicid Anatomy. — In the non-puerperal form the uterus is small, the vaginal ])ortion (lisai)j)oars sometimes entirely, so that the vagina ends in a narrow funnel, at the bottom of which is situated the OS. The tissue is hard, its arteries often calcareous, and it some- times contains foci of extravasated blocxl. The cavity of the uterus is less deep than normal. The puerperal atrophy differs in some resjM}cts from the non-puer- peral form. The walls are thin and often very soft, and the uterine cavity may preserve its normal de|)th. pjtioUxjy. — Pu(!rperal atroj)hy, or supcrinvolution, is a rare disease. It is, j)erhaps, oftener ('oiuiected with abortion than with childbirth. It is caused by loss of I)1o(h1, protracted lactation, debilitating dis- eases, such as scarlet fever, tuberculosis, chlorosis, syphilis, diabetes, Bright's disease, and exophthalmic goiter. Th(! non-j)U('rpcral atrophy can be caused mechanically by press- ure of a uterine (ii)r()i(l or an ovarian (;yst. It may l)e brought about bv trachelorrhaphy, ampntution of cervix, or oophorectomy. Sometimes salpingo-o<')phoritis seems to be tiie cause of it, and it has been found together with paraplegia. 452 DISEASES OF WOMEN. Great acquired atrophy of the uterusand ovaries occurring in a young healthy woman, who never had been pregnant, has been observed/ St/mptoms. — Senile atrophy does not give rise to symptoms unless it is combined with atresia. Before the climacteric atrophy is characterized by amenorrhea and sterility. Some patients complain of sacral pain, headache, in- somnia, mental depression, anorexia, indigestion, and general weak- ness. Sometimes the uterine cavity measures only an inch or an inch and a half, but in the puerperal form the sound often enters to the normal depth (pp. 49 and 155). Its knob is felt with unusual distinctness through the abdominal wall. Prognosis. — Puerperal superinvolution is sometimes only transitory, whereas the other forms are permanent. Treatment. — The treatment is the same as for congenital atrophy (p. 413). CHAPTER X. Gangrene. Gangrene of the uterus may occur as a result of puerperal infec- tion and is then fatal ; but an inverted uterus, a fibroid, or a cancerous tumor may slough, and in this way a spontaneous cure may occur. Treatment, — The patient's strength sliould be kept up by means of quinine, strong alcoholic drinks, and nourishing food. Locally, fre- quent antiseptic injections should be used in the vagina (p. 175), and even in the interior of the uterus. CHAPTER XL Hysteralgia. Hysteralgia, or neuralgia of the uterus, may be idiopathic or symptomatic. Idiopathic hysteralgia is a rare disease. Etiology. — It is most common at the menopause, but may be found in young girls, especially before menstruation is well established. It is also found in anemic, nervous, and hysterical women. Sometimes it is of malarial origin or due to rheumatism. Symptomatic hysteralgia may accompany any of the organic diseases of the womb, especially metritis and cancer. Symptoms. — Ilystc^ralgia is characterized by sudden attacks of severe pain in the uterus, often radiating to the sacral region, the iliac fossa, and down the leg, which recur with regular or irregular intervals. Diagnosis. — The chief point is to discover whether the affection is ' Martin Schuli, Med. Record, Dec. 24, 1898, vol. liv. p. 914. DISEASES OF THE UTERUS. 453 purely nervous or whether the neuralgic attacks accompany organic disease. Prognosis. — The prognosis is favorable if the neuralgia is not grafted on malignant disease. Treatment. — During tlie neuralgic attack nothing equals in cer- tainty and swiftness of action the hypodermic injection of morphine. In the intervals the underlying disease, if any, should be treated ; and the idiopathic form, according to the etiology, calls for tonics (p. 242), antiperiodics, or antirheumatic medicines. The galvanic current, with the positive pole in the vagina or uterus (pp. 248, 249), is very effective, and so is the high-tension faradic current (p. 246). CHAPTER XII. Displacements. The normal shape and position of the uterus have been discussed above (p. 51), and we have seen how it changes position according to the degree of fullness or emptiness obtaining in the bladder and the rectum (p. 53). Every breath makes it perform a see-saw movement. During inspiration the fundus is ])ushed forward and downward, while the cervix moves upward and backward. During expiration the opposite movement takes j)lace. During urination and defecation it is pushed down ; during copulation it is lifted up. It is therefore clear that the uterus is an umisually mobile organ. But certain ])er- manent changes and deviations from the normal take place under certain conditions, and constitute the so-called displacements. These are antevrrsion. anfcfle.riou, retroversion, retrojle.rion, lateroversion, laterojlexion, ante position, retro position, lateroposition, prolapsus, ele- vation, inversion, and hernia. Anteposition, retroposition, and lateroposition, if not due to press- ure from a neigliboring tumor, are developmental abnormalities of merely anatomical interest (p. 413). A. Antevrrsion. Anteversion (Fig. 202) is that j)osition of the uterus in which the fundus points forward, and sometimes downward, to tlie symj)liysis pubis, the os backward, and sometimes upward, toward the sacrum. The uterine canal preserves its normal direction in a line tliMt is stniight or slightly curved forward (p, 52), l'at}iol()(/ieal Aiidtounj. — The uterus is more or less enlarged ;uid in a condition ol" chronic metritis. 8()metin)es adhesions are luund 454 DISEASES OF WOMEN. between the fundus and the peritoneum or signs of celhilitis round the cervix ; or the ovary or tube may be found adherent to the anterior wall of the pelvis. Often the vaginal portion is unusually short. Fig. 262. Anteverted Uterus (Fritsch). Etiology. — Anteversion is due to inflammation of the parenchyma of the womb, in consequence of which the organ becomes larger and heavier and tips down in the erect and sitting posture ; or to inflam- mation of the pelvic peritoneum or the appendages, in consequence of which the fundus uteri is dragged forward and downward ; or to a deficient development of the vaginal portion or its operative removal. Anteversion is sometimes due to subinvolution after childbirth or abortion, but is not rare in virgins. SymjAoms. — These are the same as in chronic endometritis and parenchymatous metritis (pp. 427 and 436), especially frequent mic- turition, dysmenorrhea, menorrhagia, leucorrhea, and sterility. The frequency of micturition is probably due to pressure of the enlarged uterus, just as we commonly find it in pregnancy. The dysmenor- rhea may be mechanical, the exit for the blood being less free when the uterine canal is horizontal or even lies higher with its open than with its closed end ; or it may be explained by the increased sensitive- ness due to the inflammation of the uterus or its surroundings. The menorrhagia and leucorrhea are likewise probably due partly to me- DISEASES OF THE UTERUS. 455 ehanical interference with free circulation and partly to the structural changes in the uterus. If there are no adhesions, a peculiar, uncomfortable feeling is pro- duced by the movements of the enlarged and stiff uterus. Diagnods. — By bimanual examination the fundus of the uterus is found tipped forward, the anterior surface forms a straight line or nearly so, and the os is not situated centrally in the pelvis, within easy reach, but points backward and is only reached with difficulty. Prognosis. — Anteversion does not threaten life, but is hard to cure, mechanical disadvantages increasing the troubles inherent in the sub- jacent inflammatory conditions. Treatment. — The treatment is directed against the inflammation, or is intended to overcome the mechanical disadvantage. In regard to the first, the reader is referred to wiiat has been said above (pp. 432-435 and 437, 438). The remedies especially useful are the hot douche, glycerin or ichthyol tampon, Fig. 263. scarification, electrolysis, gold, corrosive sublimate, massa2:e, and hemostatic meas- ures (pp. 181, 182 and 243). The uterus may be lifted up by means Fig. '204. iiraily Hewitt's Antevtjrsinn IVs.sary : ab, anterior bow restiiiK on tlie ante- rior wall of the vajrina: r <, upjier end pre-ssint; on tlu; anterior surface of the uterus ; (/, pcislerior bow going behind cervix. Thomas's Anteversion Pessary: ^, lower end rest- ing just inside the vaginal cTitrance: B, unpen end to be introduced in tlie posterior pouch of the fornix: (', anterior, nioval)le bow, which is to lift the uterus through the anterior pouch of the f<iriiix. of vaginal peasarU.s — that is, supporters. Those most used for tliis purpose are Graily Hewitt's cradle pessiuy (Fig. 203), Thomas's two kinds (Figs, 204 and 205) of anteversion ])essaries, Gehrung's ])es- sary (Fig. 200). If the uterus bends over these instruments and an anteflexion is formed, they do, however, more harm than good. There is a soft-rubl)er Vienna pes.sary consisting of a tiiick elas- tic ring which surrounds the cervix, and a straight ])ieee lying in the canal of the vagina, which I occasionally have found very u>eful. 456 DISEASES OF WOMEN. General Remarks about Pessaries. — Some pessaries, such as elastic rings, work bv pressing excentricallj on the vaginal walls ; others, a class to which the above-mentioned Thomas pessary (Fig. 264) belongs, S'lo- 266. rest against the muscles and fasciae y' \ forming the vaginal entrance; Gelirung's pessary and Thomas's / i Fig. 265. / Thomas's Horseshoe-shaped Anteversion Pessary. Gehrung's Double Horse- shoe-shaped Pessary. horseshoe pessary find support on the anterior and the posterior vaginal walls. In the choice of a pessary great care should be taken never to choose a larger one than necessary. If it is made of some hard material, it is liable to erode, and even to burrow deep into the flesh and perforate the rectum or the bladder. The vagina ought, there- fore, to be inspected three or four days after the introduction of a pes- sary, in order to make sure that there is no erosion, and later the exam- ination ought to be repeated at least once every two months. If at any time it is found that the vagina becomes excoriated, the })essary ought to be left out for a week, during which the patient should use injections with carbolized water. In order to avoid erosion the ring forming the pessary should be i-ather thick and perfectly smooth. Soft rubber, and in some women even hard rubber, emits an unpleasant odor when in contact with vaginal discharges. This may be obviated by using block-tin for the construction of the pessary, but that has the fault of being heavy. An excellent material is aluminium. Hard-rubber pessaries become eroded or incrustcd, and must then be removed. Pessaries are introduced while the patient occupies the dorsal or left lateral position. In aiitedeviations the former is preferable, in retrodeviations the latter. The uterus ought, as a rule, to be replaced in the right position with tlie fingers or sound before introducing the pessary, just as fractures are set before the splint is applied. The pes- sary, except the part seized by the physician, should be smeared with a lubricant (p. 142). DISEASES OF THE UTERUS. 457 Graily Hewitt's cradle pessary is inserted with the patient on her back. First, one ring is introduced inside of the vaginal entrance along the posterior wall of the vagina, then tlie middle part is pushed up in front, and finally the second ring. The first ring is placed round the cervix ; the middle part presses against the anterior fornix of the vagina ; and the second ring rests on the anterior vaginal wall. In removing it the index-finger is hooked into the lower ring and pulled back. Thus this ring will come out fii*st, rolling over the perineum, then the middle piece, and finally the upper ring. Thomas's anteversion pessary with movable front bow is introduced closed behind the cervix, and then withdrawn a little, so as to allow one to separate the anterior bow from the rest of the instrument and push it in front of the cervix ; finally, the Mhole is pushed up until both bows rest on the vaginal vault, one in front and the other behind the cervix. (Compare rules for introducing Hodge's pessary under Retroflexion.) Thomas's horseshoe-shaped }>essarv is introduced open ; the horse- shoe is placed against the anterior surface of the uterus, and the lower bow turned forward against the anterior vaginal wall. In withdraw- ing it this bow is seized, when the remainder of the instrument follows easily. Gehrung's pessary is placed with the upper horseshoe turned down on a table, the two bows uniting the hoi-seshoes pointing toward the doctor. Next he seizes the nearest bow with the right thumb and index-finger, pushes the opposite bow into the right side of the pelvis, then the bow he holds, into the left side, and finally he turns the whole pessary in the vagina, until the two uniting bows rest on the ]>osterior wall and the two horseshoes embrace the cervix anteriorly. In with- drawing the same movements are gone through in opposite order. The best-fitting j)essarv irritates the vagina somewhat. Whenever one is worn, the woman must, therefore, at least once a day use an injection of" a pint of lukewarm water, to which may be added a tea- spoonful of borax or carbolic ac^id, in order to keep the pessary clean. She should also be instructed to remove it immediately if it causes ])ain, as neglect in this respect may cause serious pelvic infiammation. An elastic abdomhutl hell may give comfort by taking off pressure from above and steadying a large mobile uterus. The latter object is attaiiKid still better by an abdominal suj)porter witli a solid hyj)o- gastric; pad, such as tiie one represented in I'Mg. 179, p. 200. Certain opcmtlonH have proved useful in different ways. If the cervix is thl(;k, Simon's con(>-mantIe-sliaped excision (p. 4^39) may l)e performed, and result in a considerabh' reduction in the size of the bo<ly of th(! uterus (p. 438). Sims fi)lded the anterior wall of the vagina transversely, denuded the wlges of the fold just in front of the cervix and an inch and a 458 DISEASES OF WOMEN. half lower down, and united the two somewhat crescent-shaped sur- faces with silver- wire sutures (p. 234). B. Anteflexion. We know from the anatomical part (p. 52) that the canal of the uterus is normally straight or slightly curved, with the concavity for- ward, or slightly S-shaped. When it forms a more decided curve or an angle, the condition is abnormal, and is called anteflexion (Fig. 267). Fig. 267. Anteflexion (Orally Hewitt). Claitsification. — A time-honored division of anteflexion is that according to the size of the angle between the cervix and body, an obtuse angle constituting the first degree, a right angle the second, and an acute angle the third. A better classification, because of greater practical value in regard to treatment, is that into corporeal, in which the body of the womb dips too far forward and downward, while the cervix has the normal direction ; cervical, in which the cervix is turned forward ; and cervico-corporcal, in which both the body and the neck are turned forward ; each of which varieties may again be reducible — that is, the flexion can be overcome with pressure of the fingers or by the introduction of a sound ; or irreducible, when the uterus cannot be straightened.' ' T. G. Tlioma-s, Gynecol. Trann., 1888, vol. xiii. p. 142 — a paper of the greatest value to anyljody who undertakes to treat antellexion. DISEASES OF THE UTERUS. 459 Still another classification is that which distinguishes a congenital, or rather developmental, form from an acquired. Pathological Anatomy. — The bend in the uterus is, as a rule, situ- atefl at the internal os, but may exceptionally be situated higher up in the body or lower down in the neck. At the angle is often found fatty degeneration, atrophy, or cicatricial tissue. The uterus is often in a condition of chronic metritis (p. 436), with enlargement of the cavity. Frequently the supravaginal portion is elongated (p. 446). In the developmental form the anterior vaginal wall is short, the cervical portion elongated and coniform, with a small os, which some- times is situated on the anterior surface instead of at the end of the cervix. Sometimes the sacro-uterine ligaments are swollen or short- ened. The fundus may be bound with adhesions to the anterior wall of the pelvis, or similar adhesions implicate the ovaries and tubes. Sometimes the anteflexed uterus is at the same time anteverted or retro verted. Etiology. — The uterus undergoes a great development from the time of approaching puberty until the woman is full-grown, say be- tween the ages of twelve and twenty years (p. 33). During this time it is more liable to become anteflexed than after it is fully formed. The pressure of corsets (p. 131) and the weight of heavy skirts are apt to force the body down. An accumulation of hard scybala in the rectum presses the cervix forward and impairs the general health (p. 130), which again weakens the tissue of the womb. Mastur- bation (p. 318) causes hyperemia, and thus furthers anteflex- ion. Exposure during menstruation (p. 131) may have a similar effect. The acquired form is, however, mostly due to inflammation of the uterus or its surroundings : metritis, which makes the uterus heavier ; cellulitis around the utcro-sacral lig-aments, which pulls the angle between corpus and cervix uj)ward and l^ackward ; and perimetritis or inflammation of tiie a])p('ndages, resulting in adhesions pulling the fundus forward and downward. These inflammations are also caused by g(morrlical or puerperal infection, or may be simply due to colds ; that of the sacro-uterine ligaments may also originate in irritation caused by tiie j)assage of hard scybala. Anteflexion may also be due to subinvolution following childbirth or abortion ; pressure from an alxhuninal tiuiior; the presence of a growth, especially a fil)roi(i, in the wall of the corpus; and softening of the uterine ])arenciiyma in consequence of wasting diseases or insufficient nutrition. Sym/)tomt<. — Sometimes women with pronounced anteflexion enjoy perfect health, and the only thing that brings them to the ])hysi('ian is sterility. The svriiptoni next in frequency is (lysiuenonhea (]). 2511), which may be (hie to obstruction at tiie angle with formation 460 DISEASES OF WOMEN. of clots, .and which, perhaps, in other cases is rather attributable to the concomitant inflammation, the menstrual congestion pressing on the tender inflamed tissue of the womb or the surrounding parts. Young girls affected with the developmental form may also suffer from amenorrhea. The patient often complains of pelvic pain or diverse reflex disorders, es])ecially j)ain in the epigastrium, with dys- pepsia, intercostal neuralgia, headache, backache, asthenopia (p. 229), etc. She has often leucorrhea. She is often inconvenienced by fre- quent micturition, as in anteversion. Anteflexion predisposes to abortion and to hyperemesis during pregnancy. Diagnosis. — AVhen the cervix is turned forward the observer might think of retroversion, but by bimanual examination the whole shape of the womb, and especially the presence of the fundus at the ante- rior vaginal fornix, is distinctly felt. If in stout women there is any doubt, the flexion is felt still better by placing the patient in Sims's position, when the fundus tips forward on the examining finger. The direction of the canal can be made out with the sound or probe (pp. 154, 155). In anteversion the os points backward and the uterus is straight. The presence of a fibroid in the anterior wall can be made out by introducing a sound, which will enter with the normal curvature turned forward, and feeling the tumor between the sound and the vaginal vault. Inflammation and shortening of the sacro-uterine ligaments are characterized by the high position of the vaginal portion, its approxi- mation to the posterior wall of the pelvis, its forward direction, and the diminished or suspended mobility of the uterus. By direct pal- pation through the anus one or both folds are felt swollen, tender, or hardened. Prognosis. — Less pronounced cases are much benefited by treat- ment, and often cured, especially if pregnancy occurs, wliich is often the case. Otherwise there is tendency to relapse. I have never seen an anteflexed womb become straight, but the symptoms may dis- appear and the patient feel well. Irreducible cases have to be treated by 0})erations, which are, however, not sure to result in cure. Treatment. — The treatment is partly directed against the inflamma- tion, and partly it is mechanic. The patient should avoid violent exercise and tight lacing. Her skirts should be suspended by means of braces from the shoulders. Her bowels should be kejit open, and a tonic treatment followed in regard to food, regimen, and medicines (p. 242). Congestion and inflammation are combated with hot vaginal douches (p. 176), glycerin or ielithyol tampons (p. 182), painting with iodine (p. 175), and scarification (p. 194). When there is a DISEASES OF THE UTERUS. 461 Fig. 268. tendency to hemorrhage, curetting (p. 181), with or without intra- uterine packing with iodoform gauze (p. 185), does a great amount of good. The curvature may be attacked directly with sound or fingers. The sound is introduced with a curvature nearly as strong as that of the uterine canal, withdrawn, straightened, and reintroduced. Soon, if not in the first sitting, it is turned Avitli the concavity back- ward, establishing a transient retroflexion. The uterus may also be stretched bimanually by pushing the cervix back with a finger in the vagina, and pressing, with the other hand, on the fundus through the abdominal wall. If the patient is treated at home, she should con- tinue in the dorsal posture for an hour, keeping up pressure on the replaced fundus by means of a hard-rolled towel applied over the symphysis. Mild or complete dilatation with Hanks's and my dilators (p. 157) not only overcomes the obstruction in the canal at the angle, but straightens the whole uterus. By the insertion of a glass stem while it recontracts, a better shape may be obtained. Permanent dilatation is secured by Outerbridge's instrument (p. 192). Some praise electrolysis (p. 443). An abdominal belt or supporter (p. 199) may serve to take off pres- sure from above. The same pessaries as for antever- sion may be used for anteflexion. Per- sonally, I have almost abandoned them, and find that I obtain better results without them. If a vaginal j)essary may irritate and cause inflammation, tlie intra- uterine stem (Fig. 2G8) is still more dangerous.' It should be of glass, and half an inch shorter than the cavity of the uterus. It may be solid or hollow, straight or sh'ghtly bent. In order to hold it in place, it is sometimes coiubiiicd with a vagi- nal pesHjiry Juiving a little ouj) into which the plat(! of the stem fits. It siiould iuive a string attaclKd to it. It is introduced with the fingers or dressing- forceps (p. 152) through a Sims sjx'cnhiiii. Irreducible cases may l)e treated by cmj)loying the opcrati(»n : ' (iarri>^iu's, "(/'ase Illiistratin<^ tlie Danger of Stoin IVssarics," Anitr. Jour. (Jlisl , lS7y, vol. xii. p. 7o<). iiIni-iitiTin(> Slciu aiui Itclnilloxiuu- Tesi^aiy witli Cup (T. G. 'I'lioiuas). r..ii (»\\ iiig 462 DISEASES OF WOMEN. Garricjues^ Discission of the Posterior Lip} — The patient is placed in the dorsal position with elevated feet. The cervix is exposed with Gtirrigues' weight speculum (Fig. 192, p. 226), and pulled down Fici. 269. A Anteflexion OpenitiDn, S|ilitting jjosterior lip of eervix : a, Garrigues' weight speculum ; ?>, transverse furrows of vagina; r, incision in median line of cervix to uturo-vaginal junction; d, os after dilatation; e, bullet-forceps. with a l)ullet-forceps applied to the right side of the eanal. As a rule, there will be indication for curetting, and, at all events, the ' This operation, as I now perform it, is an evohition from Sims' operation, de- scribed in former editions. The advantaf;;es are absence of hemorrhage, of suppura- tion, and of danger to life or health, and a speedy recovery. DISEASES OF THE UTERUS. 46a uterus is washed out with creolin emulsion (1 : 100). Next, tlie posterior lip is cut in the median line up to the utero- vaginal junc- tion (Fig. 269, A) with KUchenmeister's scissors (Fig. 257, p. 442), and the incision extended up through the internal os with Simpson's metrotome (Fig. 258, p. 443), until the opening admits the tip of the finger. A second bullet-forceps is now inserted in the left Hap of the cervix, and the edges of the first incision are seized with a tenaculum and brought together with a running suture of chromi- cized catgut No. 2, uniting the mucous membrane of the vagina with that of the cervical canal. If there is no hemorrhage, the cavity of the uterus is packed loosely with iodoform gauze, and the Fig. 270. 7?.— Cervix split open; n, vagina; b, cut surface: r, anterior wall of Cervical canal. '/, external os. C.—a, b, c, (I, as in /// c, runnint; .'^uturo of cliromicizcil catgut, uniting the edges of the lir.vt incision. vagina is treated in the same way. If there is some bleeding, tlie uterus is ])aeked tightly, and under the vaginal gauze is ])hiee(l a hemostatic tampon of cotton wrung out of creolin (p. IH.'i). In this ease, the vaginal dressing is removed or changed the next dav. Otherwise it inav remain undisturbed ibr several days, but by ehaug- ing the loo.'je vaginal ])acking every day a more elTeetive (b'aiuage of th(! uterus and its app<'ndages may be secured, if desired. The wound lieals by first intention ; when the intni-uterine jiaeking is removed after five or six days, a glass stem is kept in the uterus during the remainder of the healing process at the inter- nal OS. 464 DISEASES OF WOMEN. If the anteflexion is complicated with considerable elongation of the cervix, the preceding operation may be combined with amputa- FiG. 271. D Z).— Side view of sagittal section : a, vagina ; b, uterus ; c, base of first incision ; d, base of second incision. tion of the cervix by cutting off the end of the open cervix before suturing it. Salpingo-odphorectomy. — If the flexion is caused by, or at least combined with, inflammation of the uterine appendages, and milder means do not lead to a satisfactory result, much benefit may be ob- tained by removal of these organs. C. Retroversion. The retrodeviations or displacements backward of the uterus are twofold — retroversion, corresponding to anteversion ; and retrojlexioji, corresponding to anteflexion. In retroversion tiie uterus as a whole is tipped backward over a transverse axis. Accordino- to the de2:ree to which the tilting: is car- ried the os points downward or forward against the symphysis pubis, and the fundus, just opposite it, turns ujiward or backward toward the sacrum. The longitudinal axis is straight. In most cases retroversion is only a transition to retroflexion, or the two are combined ; the DISEASES OF THE UTERUS. 465 pathology, the symptoms, and the treatment are identical, and since the flexion is so mnch more common than the version, Ave prefer to describe them under that heading. Diagnosis. — We have seen above (p. 460) that the direction of the cervix might lead one to think of antefiexion, but by bimanual exam- ination and the sound the direction of the fundus backward is easily made out. An anteflexed uterus may at the same time be retroverted. Then it is curved or bent forward, os and fundus being approxi- mated in front of the anterior surface, and this curved uterus is tilted backward as a whole. In these cases the os is turned forward and upward, the fundus or the posterior surface is felt lying against the rectum, the anterior surface is felt concave, and the posterior convex. The difference between retroversion and retroflexion is that in version the uterus forms a straight line, while in flexion it is bent with the concavity backward. D. Retroflexion. Retroflexion is that displacement in which the body of the uterus is bent backward, the cervix remaining in its normal position (Fig. Fici. 272. Retrnflcxion of the Uterus (Fritsch). 272). It is often combined with retroversion, when the os points downward and forward. 30 466 DISEASES OF WOMEN. Pathological Anatomy. — Besides the peculiar shape of the uterus, we find, as a rule, signs of chronic metritis, and often of pelvic peri- tonitis, salpingitis, oophoritis, or cellulitis. In many cases adhesions are found between the posterior surface and the rectum or between the appendages and broad ligaments and the posterior wall of the pelvis. Most of these adhesions are thread-like and friable; otiiei-s are spread over a large surface and very tough. The uterus is commonly enlarged, situated lower down than normal, and has a large os and a thick cervix. Retroflexion may by twisting the broad ligaments interfere with the free circulation in the pelvic veins. Etiology. — Retroflexion may be congenital, but that is much rarer than congenital anteflexion. As a rule, it is acquired. It may be due to subinvolution after childbirth. Parts of the placenta may re- main attached to the anterior wall and cause incomplete involution, by which the anterior wall becomes larger than the posterior, and a retro- flexion is the result. A frequently over-filled bladder may predispose to it. In the normal condition the abdominal pressure from above in the erect posture keeps the uterus in an anteverted and often slightly auteflexed position ; but vyhen the fundus is lifted up, so that the direction of the pressure comes to lie in front of it, the uterus is more and more tipped and bent backward. This will be favored by weakness of the round and broad ligaments, which again, in most cases, is a sequel of childbirth. This tilting may also be due to elongation of the cervical portion, or to shallowness of the cul-de-sac at the posterior vaginal fornix. The most common cause is some form of perimetric inflammation. Endometritis, very often gonorrheal in origin, leads to salpingitis, the inflammation spreads to the peritoneum, and adhesions are formed between the broad ligaments, the appendages, and the uterus on one side, and the posterior wall and the floor of the pelvis with the rec- tum on the other, which adhesions drag these organs with them backward and downward. In other cases the inflammation may spread directly through the wall of the uterus, and cause parenchy- matous metritis and perimetritis with adhesions between the fundus and posterior surface of the uterus in front and the rectum behind. Symptoms. — In rare cases retroflexion does not give rise to any symptoms. In most they are those usually found in uterine disease, and especially in chronic metritis (p. 436) : pain, dysmenorrhea, men- orrhagia, metrorrhagia, leucorrhea, dyspareunia, and dysuria. Ster- ility is not so common as in anteflexion, the direction of the uterine canal being more favorable for the entrance of the semen. Consti- pation is very common, and is easily explained by the mechanical obstruction offered by the fundus pressing against the rectum. Ner- vous reflexes and general malnutrition are, as a rule, prominent features. DISEASES OF THE UTERUS. 467 Diagnosis. — By bimanual examination the peculiar shape and posi- tion of the uterus are easily made out. It is not enough to feel a mass in the posterior cul-tle-sac of the vagina. That might as well be a fibroid in the posterior wall of the uterus or an exudation or a sar- coma in Douglas's pouch. If the uterus cannot be mapped out, tlie direction of the uterine cavity may be ascertained with the sound or probe. There are cases of flabby uterus without adliesions in which the corpus moves at tiie level of the internal os, as if there were a hinge, and the uterus is sometimes found anteflexed and at other times retro- flexed. A chief point in the diagnosis is to discover whether the uterus is movable or bound by adhesions. For this purpose examination in the dorsal decubitus is insufficient. Sometimes a uterus can be replaced with the sound in this position in such a way that the ante- rior wall of the rectum follows the uterus. This is not the case in the genu-pectoral position. By introducing a finger into the rectum in this position the adliesions are felt as tense bands. Sometimes it is possible, under ether, to replace a retroflexed uterus which seems immovable, and to retain it by a pessary. Prognosis. — In tlie great majority of cases we may expect to cure the patient, or at least make her comfortable, with a pessary. Retro- displacements predispose to prolapse. If pregnancy occurs, and the uterus does not rise spontaneously out of the pelvis, a serious con- dition may be brought al)out. In some cases operations are neces- sarv in order to procure relief, and in the laboring classes, in which harder work is combined with less cleanliness and care, they are j)referable to pessaries. Treatment. — If the uterus and its surroundings are tender, the inflammation should be combated with hot vaginal douches (p. 176), painting with iodine (p. 175), and iciithyol or glycerin tampons (p. 182) before any attempt is made to replace and retain the uterus in a i)etter position. If there are signs of chronic metritis, curetting (p. 181) and packing with iodoform gjuize (p. 185) may reduce the bulk of the uterus and form a useful introduction to other measures. Replacement. — The retroflexed uterus may be replaced in different ways. Air-pressure. — One way is to place tin; patient in the genu-pectoral position (p. 140) an<l introduce Sims's speculum. In rare cases this may suffice to make the fundus uteri sjwntaneously sink l<)rward. The pressure may be increased by means of a sponge on a sponge- holder or a cotton tampon held in a dressing- forceps ap])lied against the posterior vaginal vault. Bimannal Maniprdation. — Another way is to place the patient in the dorsal decubitus, intnxluce one or two fingers into the vagina, ami 4G8 DISEASES OF WOMEN. press their tips, with the volar surface turned up, into the posterior vault. The four finders of the other hand are inserted above the symphysis pubis and press the abdominal wall down until the fundus Fig. 273. Bimanual replacement of retrofloxed uterus. of the uterus is reached and can be pulled forward, while the fingers in the vagina push in the same direction (Fig. 273). This method can only be used on rather lean patients. Digital Pressure. — A good Avay is to place the patient in Sims's posi- tion and introduce the middle and index-fingers into the vagina with the dorsal surface turned against the back of the uterus, and press upward and forward. If the uterus is enlarged, some advantage is obtained by directing the pressure toward the .«acro-iliac synchondrosis. depositors. — Special instruments have been invented for replacing the uterus, but the simplest way is to do it with the uterine sound. It is introduced as described on p. 154, but with the concavity turned backward, and when the knob has passed the internal os the handle is pushed forward until the knob touches the fundus. Then the handle is made to circum.scril)e one-half of a large circle, so as to keep the knob on the same point in the interior of the uterus. When the concavity turns forward, the handle is brought gently back, the index- DISEASES OF THE UTERUS. 469 finger of the left hand helping to tilt the uierus forward by pressing ou its posterior .surface. As soon as a resistance is felt or the reposi- tion causes pain, the o])eration should be discontinued. Pessaries. — When the uterus is replaced, it is kept in the normal position by means of a pessary. Tiie best is Emmet's modification of Hodge's (Fig, 274). It is made of hard rubber, and is introduced Fig. 274. Hodge-Emmet Pessary. in the following way : The patient being in Sims's position, and the doctor standing behind her back, the j>essary is seized by the lower, narrow end with the right thumb and index-finger, lubri- cated, and held in the sagittal plane in front of the vulva. With the left thumb and index-finger the labia are separated, and the pe&sary is pushed tiirough the vaginal entrance pressing upward toward the j)romontory and backward against the ])erineum. When the broadest part has j)asse(l the vaginal entrance, the pessary is turned into the coronal plane. Next the lower end is seized from the point with tiie left thumb and index-finger, and the right index- finger is applied to the inside of tiic u})p('r arcii, which, by a com- bined movement with both iiands, is brought uj) l>ehind the cervix as high as possible. Finally, the right index-iinger is inserted in front of the lower arch and pushes it back, the effect of which is to pusli the up[)er arch well forward ag-.iinst the posterior surface of the uterus. Beginners arc ai)t to insert the pessary in front of the cervix, but by following the above directions they will soon succeed in placing it behind the .same. In a spacious vagina the ])('ss:iry may be introduced while ])ull- ing the perineum bac-k with Sims's speculum, a method which oilers the advantage that th(; hand is guided by the eye. Most pessari(>s on the market have too strong a curvature. This may i)C remedied by dipping them in oil and heating them in the flame of an alcohol lamp, when the hard rubber becomes soft and ("an l)e shajxnl at will. A well-fitting jx'ssary extends from the dej)th of the posterior cul-de-sac to the vaginal entrance, and takes its sup- port th<'re. It follows the normal curvature of the vagina. The 470 DISEASES OF WOMEN. lower end is bent back a little, so as to avoid pressure on the urethra. If there is much tenderness of the womb or a displaced ovary, the pressure of the hard-rubber pessary sometimes becomes intolerable. In such cases one of a similar shape, but made of whalebone covered with soft rubber, may yet prove useful. Practitioners will find a great variety of pessaries in the stores and catalogues which we can- not enumerate in a work of this kind. If the posterior cul-de-sac is too shallow to allow the Hodge pes- sary to penetrate far enough along the posterior uterine surface to keep the corpus bent forward, it is apt to bend Fig. 275. backwarcf over the pessary, which then does more harm than good. To obviate this the vagina may he deepened by meth- odical packing (p. 183). In e.xceptional cases 1 have succeeded with Fowler's pessary (Fig. 275) wlien others failed. Some use the intra-uterine stem with or Fowler's Pe>,sary. without Vagiual SUpport (p. 461). Postural Treatment. — Some help may be derived in the treatment of movable retroflectcd uteri by direct- ing the patient to spend the night on her abdomen, or at least on the sides in a semi-prone position, and to avoid lying on her back. Besides, it is recommended to let her, on retiring, take the knee- chest position, and pull back the perineum with a finger, or, better, introduce a glass tube that will admit the air right up to the vault.^ In some women it is only necessary to use the Hodge pessary for some time, say from three to six months. Others need it all their lives. General remarks about pessaries are found on p. 456. An elastic abdominal belt (p. 199) may be useful, especially in stout patients. If these milder means do not succeed in curing or relieving the patient, recourse may be had to different operations — viz. perineor- rhaphv, trachelorrhaphy, excision of cervix, extraperitoneal shorten- ing of the round ligaments, forcible tearing of adhesions, massage, hysteropexy, and intraperitoneal shortening of ligaments. 1. Perineorrhaphy. — If the vaginal entrance is torn, and the pessary does not find the necessary support, in addition to the other opera- tions, the perineum should be repaired (p. 327). 2. Trachelorrhaphy and Wedge-shaped Exeision of Cervix. — If the cervix is torn, it should be brought together (p. 419) ; and even -if it is not torn, but bulky and presenting a large canal, Gordon's operation (p. 438) should be performed. The involution caused in the body 1 H. F. Campbell, Gyn. Tranx., 1885, vol. x. p. 305. DISEASES OF THE UTERUS. 471 of the uterus by operations on the cervix (p. 438) is in many cases, together with postural and astringent treatment, sufficient to ensure the reposition of the displaced womb.^ 3. Extraperiioneal Shortening of the Round Lkjaments {Alex- ander's Operation). — This operation is chiefly indicated in cases where there are no adhesions. Its object is to keep the fundus forward bv removing a part of the round ligaments without opening the abdom- inal cavity. It is contraindicated in women who have passed the menopause, as this event entails fatty degeneration and atrophy of the ligaments. 3Iodu8 Operandi. — The pubic hairs having been shaved off, and the vagina having been disinfected, the womb is replaced with a uterine sound, and in cases of retroversion a small easy-titting Hodge pessary is introduced. In cases of retroflexion this is combined with an intra-uterine stem. The patient is then stretched at full length on her back. The operator stands on the side of the table oppo- site the ligament to be operated upon. He feels for the spine of the pubis, and makes with his nail a little dent in the skin over it. An incision is made approaching tlie j)erpendicular line a little more tlian Poupart's ligament, just in the direction of the slit between the pillars of the external ring, but so as to stay within the region covered by pubic hair, which covers the cicatrices entirely, from 1^ to 3 inches in length, according to the amount of subcutaneous adipose tissue, passing through the dent and going down to the tendon of the obliquus exteruus alxiominis muscle. Beginners should, however, first cut through the skin with one incision, then sever the sul)cutaneous connectivt! tissue with several smaller cuts in the same direction, until the superficial fascia is exposed, n(>xt divide this with one in(Msion and lay bare the ])illars in their full length and the intcrcolumnar fascia with its transverse fibers, ])artly witii the edge aud partly with the iiaudh' of th(! scalpel. The ring is situated immediately abov(; and a little outside of the s])ine. Bleeding vessels are tied or (■om|)ressed. From the ring emerges a bunch of adij)Ose tissue that contains the ends of the round liga- ment, which sprea<l out in fine filaments often hard to distinguish. Tiiis who/r nid.ss is seized with a pressure-f()rcej)s, and an aneurism- needh; inserted under it c/omc to the hone. Next we })idl on the m;iss, and see tlie white genital branch of the genito-crural nerve, which lies just in front or to one side of the ligament. If it is in tliewav.it is severed with knife or scissitrs, and so are some fine tendinous fil)(>rs runuintr fnxu the liif:im<iit to the wall of the canal. Sometimes the p!-ritoueum is in\!igin;ite(l and accompanies the ligament, from which it must i)e stripj)e<l with the fin<j:ers and pushed back. When the ' fiordon and Kiitrflmaiin, Iiitfrnational M('(li<'al Concrn'ss, l-^Sl ; Onnptf-irwln iks Irnvdux (Ik la St-r/ion 'T (Jhstt'lrii/w ct dn (lijncrdbujir^ pp. 157-1()0. 472 DISEASES OF WOMEN. li«^amont begins to peel out easily, this side is covered with an anti- septic or sterilized pad. The operator now steps over to tiie other side of the table, and repeats the operation on the other ligament. ^^'hen both ligaments are free, they are pulled out from 2 to 4 inches, until a decided resistance is met. Next, the ligaments are secured in their new position by passing two or three sutures of chromicized catgut through the pillars and the ligament, and in so doing we should keep outside of the center of the ligament in order to avoid tying the artery (p. 60), which might lead to slonghing. It is well to carry the last suture not only through the pillars, but through the fibrous tissue covering the pubes. Finally, the redundant part of the ligament is cut off, the edges of the superficial fascia united with a running catgut suture, and the external wound closed with interrupted silk or silkworm-gut sutures. In very fat women, or if the tissues have l)een much bruised, a soft- rubber drainage-tube is left in the whole length of the wound. An antiseptic dressing is put on and left for a week. Then the outer sutures are removed. The patient is kept in bed for a month, and should wear a Hodge pessary for six months or longer. If Alex- ander's operation is combined with perineorrhaphy, the pessary is introduced at the end of four weeks. If the ligament breaks or cannot be found, it is necessary to split the anterior wall of the inguinal canal. Xobody should undertake this operation M'ithout having tried it several times on the cadaver, since even experienced surgeons have found it difficult or impossible to find the ligaments. The structures mentioned above should be distinctly seen, but no muscular tissue is at any time visible. If any apjiears, it is a sign that the opera- tor has gone too deep, and he should try to find the ligament more superficially. In case no ligaments were found or that they tore, the operator should search for them from the vagina and fasten them there (p. 475). If there are signs of endometritis, it is a good plan to curette the uterus before performing Alexander's operation. Several cases of childbirth after this 0])eration are on record. If the fundus is held back by adhesions which cannot be disposed of by manipulation, hqiarotoniy should be performed, the adhesions severed, and the uterus kept forward by one of the methods presently to be described. Instead of the buried sutures, one or more silkworm-gut sutures may be inserted through the skin, the superficial fascia, the pillar, and the ligament, and left for two weeks. The intra-uterine stem is withdrawn at the end of three weeks. The Hodge pessary should be worn nine weeks or lono-er. DISEASES OF THE UTERUS. 473 Alexander lays such stress upon the use of pessaries that he declares the operation is not properly performed without them.^ The intra-uterine stem should always be used in cases of retro- flexion ; but as I as a rule combine the Alexander operation with colpoperineorrhaphy, it is not feasible to use the Hodge pessary at the time of operation. 4. Forcible Tearing of Adhesions {Schultze's Method). — When the uterus is bound down with adhesions, Schultze dilates the cervical canal with aseptic laminaria (p. 157). He introduces the index- and middle fingers into tiie vagina, and the latter up to the fundus. Next he uses this finger to replace the uterus, while the other hand grasps it through the aixlominal wall. When the uterus is replaced, it is kept in situ witli a })essary. Most adhesions are easily separated, and the operator will, of course, use a good deal of judgment in deciding which resistance he will try to overcome, and when to desist; but on account of the uncertainty as to the conditions found in the pelvis, this method is fraught with dangers, which are still enhanced by substituting a thick sound for the finger.^ It is much safer to open the cul-de-sac. In a modified form Schultze's method may, however, be recom- mendable. The cervical canal is not dilated, the patient is anes- thetized, and if there is not found any marked enlargement of the tubes and ovaries, and the adhesions are not unusually dense, they are torn by bimanual manipulations in the vagina and through the abdominal wall. 5. M(tssar/e ( Hr<rrid1\^ Method). — Not less efficacious and safer than Schultze's is Brandt's method, that obtains similar results by means of manipulations dircrtcd through the aixlominal wall and the vagina (p. 199). By this method the adlicsions are stretched gradually, and made to be absorbed by increase in vital processes.^ If, however, there is a pyosalpinx or other |)urulent collection in the ])elvis, the ])us may be pressed into the peritoneal cavity and cause an acute indamniation that may end fatally. 0. Jft/steroj}e.rl(t, or Wdinh-fitsleiiiiui.* — There are tliffereut opera- tions by which the uterus is stitched to other ])arts in order to mfike it adhere in a position that prevents it filling back again. They may be <livide(l into two classes, according to the ])oint chosen for the adhesion — viz. rdt/imtl hijsteropexid and (ibdotni)ud hifxteropcrid. A. Vaf/i)iaf IFi/.sfrrojx.rid. — In this operation the anterior wall or ' Willium Aleximiit r, I\nrlic<il Gi/iu'roloip/, I'Miiiburjjli, 1890, p. nO. ' Kricii of I'.Mltimorc, Aam: .fonr. OhM.', Oct., 18S0, vol. xiii. p. 83() ; Van de Warker of Syracuse, (iiju. 'I'mnx., 1881. vol. vi. p. 18'). ' lu)r {Ictails tlu- reader is referre<l to |)r. V'inebertr's pa|)er, (juoted on ]>. ISS. * Hysftcrd, wonil) ; ju'tptiimi, i fastcTi. Tlii.s name i.s more correct than liystcnirifi(ipfii/, which means oniv womh-sewin''. 474 DISEASES OF WOMEN. the fundus of the uterus is made to adhere to the anterior wall of the vagina by the introduction of temporary sutures.* It ox})oses to pain during pregnancy, abortion, or great difficulties in delivery, even the Cesarean section having become necessary on account of the unnatural position of the os upward and backward, Avhich prevented engagement of the fetus. Other operations should, therefore, be preferred. B. Abdominal Hystcropexia, or Ventro-fixation of the Uter'us. — In this operation the uterus is attached to the abdominal wall. There are many varieties, but wc shall describe only one. Kclli/'s 3Ietho(h'^ — An incision is made in the median line, be- tween three and four inches in length, beginning about one and a half inches above the symphysis pubis. The uterus having been lifted up, a ligature is carried through the parietal peritoneum and adjacent tissue one-eighth of an incli deep and a third of an inch wide, and througli the posterior wall of the uterus below the fundus, and finally through the peritoneum and adjacent tissue on the other side. When this suture has been tied, a second is carried in a similar way just above the first on the abdominal wall and below it on the ])ostcrior wall of the uterus. Adhesions form at once, but stretch, so that after a short time the organ is found mobile, with the fundus well forward in an easy anteflexion and with a marked space between it and the abdominal wall to which it was attached. In a subsequent laparotomy the adhesions have been found drawn out to a cord two inches long, extending from the abdominal wall to the fundus of the uterus. Such a cord contains an clement of danger in regard to intestinal obstruction ; but so far no such case has been reported, although the operation is extensively performed. C Desmopexia, or FaHfcniv<j of the Rouvd Lic/aments. — Instead of attacking the uterus itself, the round ligaments may be used to correct its position. a. Ventrofixation of the Round Ligaments. — a. Olshausen's Method.. — After having opened the abdomen as described, and lifted the uterus up, three sutures of chromicized catgut (Leaven's No. 1) are carried on each side with a curved needle through the round ligament and the peritoneum, transversalis fascia, and part of the rectus abdominis or pyramidalis muscle, at intervals of about half an inch, the upper- most being inserted near the cornu of the uterus. The needle should not be carried so deep into the ligament as to interfere with the funicular artery (p. 59). All six sutures are inserted before any ' Mackenrodt, Deutsche med. Wochensc.hr., 1892, No. 22, with improvements I'V Winters (Centralbl.f. Uynak., 1893, No. 27, p. 627), Diihrssen {ibid., No. ;^0, p. ti90), Orthmann {ibid., No. 45, p. lOoS), and others. ■■'Howard Kellv, " Siis[)ension of the Uterus," Jour. Amer. Med. Ashoc, Dec. 21, 1895, vol. XXV. p." 1079. DISEASES OF THE UTERUS. 475 of them is tied. The uterus should be lifted sufficiently to leave only a narrow slit between it and the bladder. Before tying, the operator makes sure that neither the intestine nor the omentum is in the way. /9. Beck's Method^ is an adaptation of Bassiui's operation for inguinal hernia. The abdomen is opened in the median line and the uterus lifted up by means of a volsella or a temporary suture through the fundus. One of the round ligaments is separated from the broad ligament, near the uterus, and a loop about one and a half inches long pulled out of the peritoneal cavity. Next, the peritoneum is united behind the loop, and in a second layer tlie aponeurosis of the ol)liquus externus muscle, piercing the loop at both ends. Finally the abdominal wound is closed. 6. V(i(final Fixation of the Round Ligamentn ( Vineberg's 3Iethod).^ — The operator seizes the anterior lip with two volsellsn and draws the uterus down to the vulva. Another volsella is inserted into the anterior vaginal wall, just beyond the urethral mound, and the ante- rior wall put on the stretch. Next an incision is made from the urethral mound to the cervical attachment of the cervix, and the two flaps are separated from the bladder, using partly the handle and partly the edge of the knife. The sej)aration should be gener- ous, in order to gain room. The two flaps are then held asunder by tenacula near the cervix ; Avitli a stroke of the knife the vesico- vaginal septum is divided, and the bladder separated from the uterus with the iudex-tiugcr. It is well to insi'rt the two in(l(\\-tiugers into the opening between the bladder and the uterus and dilate it as much as possil)le, avoid- ing undue force. The cervix is now pushed backward with the two volselije, and Enghsmaun's retractor is inserted into the op(>ning, so as to hold the bladder out of the wav. liy this nuuneuvre the lower part of the anterior surface of the uterus is exj>osed. A traction suture is car- ried through the anterior wall as high as one conveniently can, by means of a short, stout curved needle. With this suture the Ixxly of the uterus is drawn downward and forward into the incision. Now is a convenient time to snip open the peritoneum and enlarge the opening with the fingers, providecl an opening lias not already been made in it in the elfort to strip the bladder from the uterus. If no adhesions exist and the uterus is not overlarge, it mav now be ti))ped outside the woutxl by hookintr two fingers over the lundus. If th(! direct palpation shows that the adnexa are normal, tiie uterus need not be pulled out in /o/o, i)uf the two fingers are hooked Ix'hind Tarl r.t'ck of New \i,rV, ('.•nlnilhliill flir (ii!niri/lr. 1897, No. .'?.''.. ^ Hiram N. N'iiiflicrt,', Ainrr. Jom; Obnl., vol. xxxvi., No. 1, 1S!)7, ami 7';yhi.s. Artwr. (lyn. Soc, 1S'.*7, vol. xxii. pp. 2*>9-2H2. 47G DISEASES OF WOMEN. one horn and the corresponding end of the tube, and the round hVanient is drawn well into the incision. If inspection of the adnexa is desired, tiie uterus is brought outside the wound either by the lingers, as just described, or by traction sutures, inserted one above the other on the anterior wall. Bullet-forceps are less recom- niendable, as they are likely to tear the uterine tissue. Cases are met with in which the adhesions are so extensive or the infundibulo-pelvic ligan)ent so short that the a])pendages cannot safely be brought out. Then it is better to adopt the suprapubic method. If the round ligaments can be brought well within reach, a silk- worm-gut suture is carried around it from behind forward, about an inch and a half from its uterine end. A similar suture is passed half an inch nearer the uterus. The four ends are carried through the vaginal flap by means of a silkworm-gut carrier, which has the advantage over silk of being stiff and not becoming ravelled. The same is done on the opposite side, the uterus replaced, the traction sutures removed, the vaginal sutures tied, and the slit in the peri- toneum closed with a running catgut suture. Finally, the vaginal flaps are united with the same kind of suture. If there is a cystocele, they are first shortened. The last couple of stitches are made to enter the cervical tissue so as to attach the vaginal wall to the cervix. D. Dcsmorrhaphy. Intrdperitoneal Shortening of the Round Lig- aments. — The ligament is folded on itself, forming a single ( Wylie^s method ^) or a double (Mann's method') loop. The peritoneum is scraped off where the folds of the ligaments touch one another, and the latter stitched together w-ith chromicized catgut. Taifs Method produces a shortening of the round ligaments by passing the ligature for removal of the appendages (see Diseases of the Tubes) under the ligament, so as to include a loop of it in the part that is cut away. Gaffe's Method.^ — While in all these methods the ligaments are reached by lajiarotomy, Goffe obtains access to them through the vagina much like Vineberg; but he shortens the ligaments by fold- ing and stitching them together, and does not fasten them to any other organ, in which respect he follows a method described by Bode ;* but he secures much more room than that operator, and he avoids the use of traction sutures or l)ullet-forceps on the body of the uterus. He drags the cervix strongly down with a volsella, and makes a transverse incision on the anterior wall of the vagina one inch in >Gill Wylie, Am^r. Jour. OhM., May 18S9, vol. xxii. p. 484. *M. D. Mann, Trnns. Amer. (h/n. Snc.. 1897, vol. xxii. M. R. Goffe, Trans. Amer. Gyn. .^V., 1897, vol. xxii. pp. 2.S4-241, and 1898, vol. xxiii. p. 71. * Bode of Dresden, Centralhl. f. Gyndk., 1896, No. 13, p. 358. DISEASES OF THE UTERUS. 477 front of the cervix, the low position of the incision facilitatin<^ the swinging back of the cervix when the fundus is being delivered into the vagina. By blunt dissection, as in hysterectomy, the bladder is dissected from the uterus up to the peritoneum. The lower edge of the transverse incision is then caught with two artery forceps near to the median line, and a longitudinal incision is made at right angles to the first, through the vaginal wall, down to the origin of the urethra. The two lateral flaps are dissected from the bladder an inch or an inch and a half on each side. The ])eritoneum is now opened and torn freely toward each side by passing the two index- fingers through the opening and making lateral pressure. The uterus and appendages may now be pulled into the vagina with a finger hooked over them. The round ligauient is caught with an artery forceps as far out from the corner of the uterus as will permit the point at which it is caught being drawn to the site of origin of the round lijniment — a distance varviny: from two and a half to three inches. A fine silk suture is drawn through a point midway between the forceps and the corner of the uterus, and through another point at the same distance from the forceps on the distal side of the liga- ment. When this suture has been tied, another suture fastens tiie point held l)y the forceps to the origin of the ligament. The other ligament is treated in the same way, the uterus replaced, and the peritoneum and vaginal wound closed. Severance of Adhemoiia. — In all cases in which the abdominal cav- ity is opened, adhesions that hold the uterus in its faulty i)osition should be severed, beginning at the distal end of the broad ligaments. As a rule, this can be done with the finger alone; but sometimes tiie adhesions are so tough that they have t«» be tied with a double liga- ture and cut witii scissors, or they have to be severed with the thermo- or electro-cautery. If there is much bleeding from torn adhesions, it may become necessary to use a provisional intra-abdominal tampon of iodoform gauze (p. 18(J). Kramiiififion of Aj>pe)i(l(i(/cs. — When the abdomen is op(Mied the appendages should be brougiit into view, and, if seriously affe('t(>d, they should l)e removed. In the; latter ease (Mth(T the stumj)s or the fundus uteri inav be fastened to the abdominal wall. The a])|)end- ages may also b<' treated in any way desired, through the vaginal incision. 7V.s.sr//-//. — In all eases of direct or indirect hvsteropexia a Hodge ]K'ssarv should be introduced and worn for several months. The bladder soon ae<'oniino(lates itself to its new relations with the ut<'rus. Shortening of the saero-uterine and the infundibulo-pelvic liga- ments has also been attempted for the correction of retroflexion, but without success. 478 DISEASES OF WOMEN. In regard to tlie laparotomy forming part of most of the above- mentioned methods the reader is referred to the description of Ovariotomy. In the writer's opinion it is hardly warrantable to perform laparot- omy for retroflexion alone; bnt if the appendages have to be removed, or if adhesions canse great pain and cannot be disposed of otherwise, it may be nsefnl to attend to the retroflexion at the same time in one of the ways mentioned. Comparison between the Different Operations for Retroflexion. — Alexander's operation offers the great advantage that the peritoneal cavity is not entered, and that the scars, covered by hair, become practically invisible. If tlie uterns is movable and the appendages healthy, and the patient is not so old that the ligaments arc atro- phied, that ought to be the operation of choice. If the appen- dages are diseased, they may be examined, treated, or removed by either the abdominal or the vaginal section, the first of which gives more room and is always available ; the second leaves no abdominal scar, but is more diflficnlt and has sometimes to be abandoned. (See p. 476.) All operations that are directed against the round ligaments are preferable to those that fasten the uterus to other structures, because they present no danger of intestinal obstruction or dystocia. E. Lateroversion and Lateroflexion. Lateral deviations of the uterus, unaccompanied by other patho- logical conditions, are rare. They may be congenital (p. 413) or due to inflammation later in life. The displacement is often produced by inflammatory exudations in the pelvis or tumors in the broad liga- ments. The diagnosis is made by bimanual palpation or the sound. These displacements are apt to cause sterility. No direct treatment is applicable. F. Prolapse. Prolapse, Prolajisus, Descent, Procidentia, popularly called Falling of the Womb, is that displacement of the uterus in which it sinks down to a lower position than normal. Some authors reserve the term " prolapse " for the lesser degrees of descent, in which the uterus is inside of the vagina, and designate by " procidentia " only the highest degree, in which the uterus sinks more or less completely out of the body and hangs between the thighs. Others call the first degree incomplete, and the second complete prolapse. Prolapse is sometimes acute ; that is to say, it may occur suddenly in an otherwise healthy person, even a virgin, while making a mus- cular effort, but this is rare. It has also been observed in a child. DISEASES OF THE UTERUS. 479 in consequence of diarrhea, a few days after birth, Commonly it is chronic; that is to say, it is developed slowly and gradually. In the latter case it is combined with more or less hypertrophy and metritis. Pathological Anatomy. — The vagina becomes inverted, as in supra- vaginal hypertrophy (p. 446), but in prolapse the peritoneal pouches in front and behind the uterus are dragged down with it (Fig. 276). Fig. 276. Procidentia Uteri, with pared surfaces for Lefort's operation: A, anterior denudation; B. posterior denudation ; I/, fundus uteri; L'/J, meatus urinarius; if, rectum. Etiology. — As just stated, the acute prolapse is due to a muscular eifort in carrying a heavy weight, such as a tub with water, in front of the body. The chronic is mo.stly referable to childbirth. Tiie vaginal entrance being ruptured (pp. 821 and 324), the uterus does not find its usual suj)p()rt ironi below. It becomes retroverted and then retroflexed (pp. 464 and 465). Intra-abdominal ])ressure drives it like a wedge down through the vagina. The sacro-uterine liga- ments (p. 55) become weakened and elongated, tlie pelvic c(mnective tissue lo.ses its tonus, and the weight of the subinvoluted vagina drags the uterus down (p. .356). Finally, the uterus sinks by its own weight. Thus lack of .<uj)|)ort from above and below combines with v/eight, pressure, and dragging to displace the uterus. Thedes<x'nt may also b(! (hu; to tum(»rs in the uterus, which inerea.se its weight, or in the alxlomen, which j)ress on it. The incre:i.se in weight and succulence ol' all pelvic structures caused by pregnancy may also result in prolap.se. 480 DISEASES OF WOMEN. Symptoms. — The symptoms of chronic prolapse are identical with those of hypertrophy of the cervix (p. 447). The acute form is accompanied by sudden severe pain, faintness, and peritonitis. Diagnosis. — A polypus and an inverted uterus form tumors with- out the opening at the lower end leading into the interior of the tumor. Prolapse dift'ers from supravaginal hypertrophy by the low position of the uterine body and the normal or only slightly increased depth of the cavity. The lesser degrees of prolapse become more apparent in the erect posture (p. 138). Treatment.— If there is an ulcer, it ought to be treated with the ointment of iodoform and balsam of Peru (p. 284) ; and secondly the uterus should be replaced and retained. As a rule, common pes- saries cannot be retained, on account of lack of support from the perineum. A large soft-rubber ring, an inch thick (Mayer's pes- sary), will sometimes retain the uterus in the pelvis by distending the upper part of the vagina. Breisky recommends large ovoid Fig. 277. uterine and Abdominal Supporter. bodies of hard rubber. Gariel's air-pessary consists of a soft-rubber bag, which the patient can introduce herself into the vagina and fill with air. In most cases of complete prolapse it is necessary to use supporters composed of a cup and stem pressing against the vaginal portion and fastened to an abdominal belt (Fig. 277). This appa- ratus is removed during the night, and the cup cleansed with some disinfectant. DISEASES OF THE UTERUS. 481 Operations. — As a rule, combined operations are required, and even they may not always prevent a return of the condition.^ Trachelorrhapliy, excision of a piece, or complete amputation, of the cervix, is used for reducing the bulk of the uterus (p. 418) ; Alexander's operation (p. 471) is combined with colpo-perineor- rhaphy (p. 327) ; abdominal hysteropexia (pp. 474-477), or abdom- inal or vaginal desraopexia (p. 477), or vaginal shortening of the round ligaments, is also used to hold up the uterus, in order to fasten it above and support it from below. Fig. 278. Lefort's Prolapsus Operation: ^.anterior (Kiiiuiaiioii ; 7;, posterior denudation; C C, upper right lateral sutures ; J> J/, upper left lateral suture. Leforf'i^ Oprrfifioii. — For complete ])rolapsus I^efort's operation of pardfionirir/ t/ir rnr/itift is vahial)U' by ])roviding a solid cohmin of tis- sue right ill the middle of the vagina for the uterus to rest on. In the middle of the anterior surfiice of the tumor hanging in front of the vulva a ])arallelogram three-tjuarters of an inch wide and over two inches long is denuded close up to the vulva. Next, the tumor is held up and a (•orresj)ondiug denudation is made on the pos- terior surface. Then the; uterus is replaced sufficientlv to bring the two u|)per ends of the jiared surface.-^ in contact, and to unite them ' I (iiiiibiiicd ill one case rein ival of tlie ap])eii(Iaf;:es, ventrofixation of tlic iitonis, Tail's perineal flap operation, and Stol/.'s cvstoeele operation. I"'or a lime tlic snc- eess was coinpiete, but a year had not elapsed before the uterus was i)r()iapsed a^airi. 31 482 DISEASES OF WOMEN. with a riinninj; suture of ehromicized catji;ut, whicli is continued tier after tier until the entire surfaces are brought together (Fig. 278). It is a good plan to combine a perineorrhaphy with this operation.* An improvement by Coe consists in introducing several rows of buried catgut sutures in the middle of the wound, each row covering the preceding one. Chromicized catgut is particularly well adapted for this operation, since the sutures cannot be removed, and ought to resist dissolution for some time (p. 216). This operation does not interfere with coition, since it only forms a double vagina ; but in case childbirth should take place the artificial septum would probably be destroyed. The operation is, therefore, particularly indicated after the menopause. In women who are beyond the child-bearing period, or who are absolutely incurable by any of the conservative methods, Mund^^ has resorted to the high amputation of the cervix by making a circu- lar incision around the cervix, pushing up the vaginal walls with finger and scalpel-handle, and removing the bladder and the perito- neum of Douglas's pouch from the seat of operation. Having thus exposed an inch to an inch and a iialf of the raw cervix, he am})u- tated it with the galvano-caustic wire. Passing a tent of iodoform gauze into tlie cervix to prevent the closure of that canal, he returned the uterus into the pelvic cavity and packed the vagina with iodoform gauze. The cicatricial contraction of the vaginal vault resulted in forming so firm an attachment that the uterus was retained in its normal position. Freund's operation'^ is mentioned only in order to warn against it. It consists in the insertion of three or four silver wire rings under the mucous membrane of the vagina, one below the other. It can only be used in old women, since it excludes connection. It is said to be so painless that it can be performed without anesthesia, but it is decep- tive, since the Mires soon cause suppuration and come out. Vaginal Tli/deredomy. — In those very rare cases of jirolapse that have resisted all other methods, or when the uterus is diseased, and the woman has passed the mcnojiause, the extirpation of the ])ro- lapsed uterus is justifiable. In performing it, a considerable part of the vagina must also be removed. The modus ()))eran(li^ is the fi)l- lowing : The patient is in the breech-back position (]). 388). The uterus is curetted and disinfected. Each lip of the vaginal ])()rti()n is seized with a traction f()rce})s (p. 228), and the cervix is j)nlled ^Fannv Berlin of Boston, Aiupr. Jour. Ohf<L, Oct., 1881, vol. xiv. p. 870. •' P. F.'Mundo, Amer. Jour. OhM., Nov.. 1891, vol. xxiv. p. 1291. ^ H. W. Frcnnd, Centralhl.f. Oynuf:., 189.'5. No. 47. vol. xvii. )). lOSl. * I have evolved this method from the description of H. Fritsche's operation given hy Asch, Archiv/iir Gyndkologie, 1889, vol. xxxv. p. 20(5. DISEASES OF THE UTERUS. 483 well upward (Fig. 279). Now an incision i.s made on the posterior vaginal wall, between the middle and upper third, in the shape of an acute angle, the top of which is situated in the median line and points backward toward the posterior commissure, whereas the sides extend to the side of the cervix. The incision goes through the whole thickness of the vaginal wall, and is deepened with tiie finger and closed with blunt scissors, until the peritoneum in Douglas's pouch is exposed. The peritoneum is seized with two pairs of Kocher's tissue-forceps (Fig. 199, p. 229) and cut transversely with scissors. Fig. 279. HysterertDiiiy fur proliipsod uterus. The next ste|) is to stitch the posterior flap of the peritoneum to the posterior vaginal wall, and to ins(>rt a sponge with attaclied thread >o as to retain the intestines. Next, the vaginal ])ortion is carricnl i'ar down, and an incision similar to that on the posterior wall is ina<l(> on the anterior wall of the vagina (Fig. 2.S0), but only tlirough the vaginal wall, without entering the bladder, and, if there is a large cvstoeele, extending to the mound of the urethra and joining the ends of the posterior incision on the sides of the cervix. This trianguhir flaj) is separated IVoiii the bladder, partly with blunt instruments and partlv with the knife ; a transverse incision is made just below 484 DISEASES OF WOMEN. the bladder. This organ is separated from the uterus, and the peritoneum of the vesico-utcrine pouch incised, after having secured the anterior flap with a silk thread. The uterus is easily retroflexed and pulled out. The intestines and the omentum are kept back by a pad with a string attached to ir. The broad ligaments are tied in portions from their upper edge downward to the point where the incisions meet on the sides of the cervix. This is done with a half-sharp-pointed needle (Fig. 270, Fig. 280. Hysterectomy for prolapsus uteri. p. 463). As soon ais a portion is tied, it is cut between the ligature and the uterus. If the ovaries are healthy, one or botli should be left in. AVhen the uterus has been removed, the edges of the wound on the anterior wall are whip])ed together with a running catgut suture ; the stumps of the broad ligaments are fastened in tlie vagina ; and finally the peritoneum of the; bladder stitched to the anterior ciniumfcrence of tlie vagina and the opening in the vagina packed with iodoform gauze. DISEASES OF THE UTERUS. G. Elevation. 485 The uterus may be raised by tumors in the pelvis, or ascend by its own size, as in pregnancy, or be pulled up by contracting Fig. 281. Supra- and infra-vapinal hypertrophy of the cervix. Specimen removed by vajiinal hys- terectomy': ri, hypertroj)hied vafriiiiil i)ortioii; /j, tumor full of cysts ; r, jiiirt of the vatfina removed; d, hypertrophied supravaKiual cervix; r, corpus uteri;//, KalJoi)iaii tubes; ;/ ,'/, ovaries. inflammatory adhesions. Sometimes the whole vauinal portion disappears. 11. InrerKion. Inversion consists in a turning inside out of th(> uterus (Fig. 2S2). It may be fofal or jxirtu/f. As a rule, tlie inversion begins as an 'Specimen obtained from mv openition on Mrs. II. at St. Mark's Hospital. Aug. 8, 1898. 486 DISEASES OF WOMEN. indentation at the fundus, but it may also begin in the cervix, subse- quently dragging down the body. We distinguish three degrees. In the first degree the inverted part is found inside of the uterus ; in the second, it has descended into the vagina; and in the third it is combined with prolapse and hangs outside of the vulva. Inversion comes under observation at three different periods: Section of the Second Degree of Inversion of Uterus (Crosse): a, vagina; b, fundus uteri; c,c, angles of inflection ; c,c, d,d, extent of uninverted cervix ; e, vaginal wall ; /, the perito- neal cul-de-sac of the inverted uterus ; g,g, Fallopian tubes passing down into tne in- verted uterus ; h.h, ovaries ; i,i, broad ligaments ; k,k, round ligaments. immediately after the occurrence of the accident, especially during or immediately after childbirth, in regard to which the reader is referre<l to works on obstetrics ; about six weeks after labor, when hemorrhage or other symptoms induce the patient to seek advice ; and, finally, a long time, often many years, after its formation. Etiology. — Inversion is a very rare accident, only one case having occurred in about 1 50,000 cases of delivery. The most common cause is childbirth, especially if it takes place in the erect posture, if the cord is too short, if the accoucheur or the midwife pulls on it in order to remove the placenta, and if it is inserted on the fundus. But the inversion may also take place some time after the birth of the child, especially at the time of getting up, although the lying-in period has been normal in every respect. Laceration of the cervix may predis- pose to it. After abortion it is still rarer than after childbirth. It has also been observed in connection with a vesicular mole. Secondly, a tumor of the fundus uteri, especially a fibroid, being expelled, drags the uterus along. Thirdly, inversion may occur when the uterus is enlarged and its tis- sue softened, indej)end('ntly of pregnancy and the presence of a tumor. Where there is no tumor, the mechanism is the following : A part of tlie uterine wall, most frequently the placental site, becomes par- alyzed and sinks down, while the surrounding parts contract above it. DISEASES OF THE UTERUS. 487 Thus a kind of peristaltic movement is set up, proceeding from above downward. But if the inversion begins at the cervix, the movement takes place in the opposite direction, from below upward. Pathological Anatomy. — The inverted part of the uterus may only be a cup-shaped depression near the fundus ; or it may form a pear- shaped body, the lower end of which does not ]iass the internal os ; or it may hang in the vagina, the pedicle being surrounded by a ring formed by the cervix ; or the whole cervix and part of the vagina may have become inverted in their turn. If the tumor is yet retained in the body of the uterus, it is covered with a dark-red, swollen mucous membrane that easily bleeds. On the lower end may be seen two minute openings, admitting a bristle, which are the uterine ajjertures of the Fallopian tubes. When the inverted part lies in the vagina, its mucous membrane sometimes loses its glands and becomes like that of the vagina. If it is expelled outside of the ])atient's body, it often ulcerates and cicatrizes, which gives it a cutaneous a})pearance. Seen from the peritoneal cavity, the inverted uterus forms a funnel- shaped depression, into which descend the Fallopian tubes, the round ligaments, and sometimes the ovaries. In old cases this funnel may be impervious, the contiguous sides of the peritoneum having grown together. tSi/mptoms. — In most cases the inversion of the uterus, taking place suddenly in connection with childbirth, is accompanied by marked symptoms — hemorrhage, pain, collapse, and the formation of the cliaracteristic tumor in the vagina and the funnel above the symphy- sis. But in exceptional cases all alarming symptoms may be absent.^ In the subacute and chronic forms the chief symptom is again hem- orrhage, which may undermine the constitution by its frequent recur- rence or profuseness, to which are added Icucorrhea, dragging pain, difficulty in walking, and different nervous reflexes. Physical exam- ination reveals the peculiar shape of the fundus and the })resence of a tumor in the vagina. DiafjiKix'ix. — Tile diagnosis of inversion, apart from obstetric cases, may be very difficult, and is of the utmost importance in regard to treatment. Only great careleasness could fail to distiuguish common prolapse and In/pcrtrophi/ of the cervix from inversion, the distinctive feature being the j)resence of the os uteri at llie lower end, through which the soiuid can be entered more or less deeply. The tumor in prolapse is broader at the upper end than at the lower, whereas the opposite is the case with an inverted uterus. A catheter goes downward into the cystocele accompanying prolaj)se, but upward in rase of inverted uterus. A />oli//)U.s may offer entirely similar symj)- ' .John ('. lieeve has contributed a paiier full of instruction, on Inversitui, in ('t/n. TrartK., 1884, vol. ix. p. 69. 488 DISEASES OF WOMEN. toms, and a tumor of the same shape and appearance may be found in the same ])laee ; but if it is a j)olvpus the sound can be introduced to the depth of a normal uterus or deeper between the tumor and the cervix, while in inversion it is soon arrested at the place where the uterus is inflected. Bimanual examination shows, when we have to do with a polypus, that the uterus is in its j^lace. If, especially in stout women, the uterus cannot be felt through the abdominal wall, recoui'se may be had to rectal examination (p. 144). A catheter held in the bladder may help to settle the diagnosis, and if there is any doubt the urethra should be dilated (p. 144), and the index-finger introduced into the bladder, from which it can palpate the uterus. If it is a case of inversion, these same manipulations will show that the uterine body is not in its place, and that instead there is a funnel- shaped depression. It is also claimed that if a needle is thrust into the tumor, it will cause pain in an inverted uterus, but not in a polypus. If we have a fibroid as cause of the inversion, and it is yet in the uterus, the differential diagnosis may be particularly difficult. Under such circumstances the sound enters to its usual depth, but the depres- sion of the fundus can be made out by the above-named means. If the fibroid has dragged the uterus down with it, the sound does not enter, but it becomes necessary to distinguish which part of the tumor is the uterus proper and Avhicli the fibroid. In this respect the fact that the fibroid is harder, nodulated, and painless on acupuncture is an aid to diagnosis. If adhesion takes place between the pedicle of a polypus and the cervix, the sound cannot enter, but then the uterus is found in its normal place and of normal shape. A similar condition obtains when it is a so-called holloio polypus^ an exceedingly rare disease, the pathology of which is not quite settled. There is found a tumor in the vagina as in common polypus and inver- sion, but the sound cannot be made to enter anywhere between the pedicle and the cervix without violence. This tumor is soft and con- tains fluid, which distinguishes it from a fibroid polypus adherent to the cervix. One theory is that a plastic deposit is produced on the endometrium, and that blood or other fluid accumulates between it and the uterine wall, lifts it up, and forms the ])oly])oid tumor tliat is ex- pelled through the os. Another theory is that it is the endometrium itself that becomes detached and peeled off down to the cervix. A third possibility — and, in my opinion, more likely than either of the others — would be that a common fibroid })olypus contracts adhesions with the cervix ; that its interior becomes myxomatous and melts, forming a cyst in the way we shall see in studying the formation of fibro-cysts, which cyst later communicates with the uterine cavity by absorption of the partition. However this may be, the fact is that ' Sussdorff, Jour. Obat., 1877, vol. x. p. 553. DISEASES OF THE UTERUS. 489 we have a sac filled with fluid protruding through and attached to the cervix. The sound does not enter, but the tumor is softer than an inverted uterus. By pulling on it, the relations between it and the cervix remain unchanged, whereas in inversion the cervix becomes more inverted or disappears altogether. Examination through the rectum practised while this traction is made will show that the ute- rus is in its place and has its normal shape. If the sound is made forcibly to penetrate the obstacle round the pedicle, it enters a cavity of the normal depth of the uterus. Prognosis. — Inversion of the uterus is a very dangerous condition, accompanied by great mortality. The total mortality is 20 per cent., but it is far less in chronic cases than in obstetric practice. Spon- taneous replacement is possible, but rare. Another spontaneous cure, accompanied by the dangers of septicemia, is occasionally brought about by gangrene of the inverted mass. Most of the measures adopted for the cure of inversion are more or less dangerous. Treatment. — The measures to be taken for the inversion occurring during labor are taught in works on obstetrics. Here we treat only of more or less old eases. Experience has shown that the best treat- ment is that with elastic pressure. The vagina is disinfected and Aveliru/s repositor applied. It is made of hard rubber, and consists of a little cup which presses on the inverted fundus, and an S-shaped rod, which protrudes from the vuK'a and carries pressure made at its lower end u})\vard in the direction of the pelvic axis. To the lower end are attached four elastic tapes, which are drawn through rings fastened to an abdominal binder. Two of the tapes are brought for- ward and two backward, and they enable us to give the rod the desired direction. A pressure of two and a half pounds is sufficient. Tiiis method is safe, hardly ever fails, and leads to replacement in a short time — from nine to fifty-four hours — by starting an anti- peristaltic movement, so that the part forming the pedicle is first replaced, and the fundus last. The same principle of elastic pressure may be applied in difi'crent ways. A soft-rubber cup is attached to a curved hard-rubber stem, from the end of which tapes go to rings in a belt round the abdomen (Barnes). Another way, that disjK'Uses with the use of any ])Mr- ticular instrument, is to i)a('k the vagina firmly with iodoform gauze, which is renewed every two or three days. During all these treatments the |)atient is kept in bed, and if ne('(>s- sary the pain relieved by hypo(lermi(; injections of morj)liiue. If the elastic ])ressure does not succeed, recourse is had to onv. of the following methods of manual rcphtccmcnl, which are used on the an<!sthetized patient. Kmmet surrounded the tumor with the finwrs of the lefi IimikI and 490 DISEASES OF WOMEN. pressed at the base, making counter-pressure through the abdominal wall on the ring in the peritoneum. Xoeggerath applieil the tliumb and middle finger to the horns of the uterus, replacetl first one of them, then the otiier, and finally the fundus ; counter-pressure was made as in Emmet's method. Courty introduced two fingers of the left hand into the rectum, which allows pressure on the cervical ring with greater eifect, while the fingers of the right hand press at the base of the tumor in the vagina. Tate of Cincinnati dilated the urethra, introduced the right index-fin- ger into the bladder, and pressed on the ring from this side, at the same time using the left index- and middle finger in the rectum, as Courty did, and applying both thumbs to the horns as in Noeggerath's method. It must, however, be borne in mind that such dilata- tion of the urethra occasionally has led to incontinence of urine (p. 1-44). If a partial reinversion is obtained in any way, Emmet's device, of pulling the lips of the cervix together over the still inverted fundus, and uniting them with deep silver-icire sutures, may be followed. Thus an elastic pressure is obtained that may lead to complete replacement. The efforts to reduce the inversion must be continued as long as possible, say for half an hour, different operators relieving one another. If one method does not succeed, and her condition war- rants delay, the patient should be given a few days' rest, and another method tried. In the meantime, the tumor may be softened with warm vaginal injections, sitz-baths, and glycerin tampons. Conservative Cutting Operations. — Thomas performed laparotomy and dilated the cervical ring with an instrument like a glove-stretcher. This method would probably be the best in old cases in which adhe- sions have formed between the walls of the internal ring. Barnes pulled the tumor well dow^n with a tape, and made three longitudinal incisions in the cervix. After that he could easily replace the tumor by manipulation. Kiistner performs posterior transverse colpotomy (p. 171), intro- duces the left index-finger into the funnel-shaped depression formed by the inverted uterus, and tries reposition. If it does not succeed, he makes a longitudinal incision in the median line, through the whole posterior wall of the uterus, when the reposition becomes very easy. Next, the uterus is rctroflexed and drawn into the wound in the vagina, the incision in the uterus closed with a running suture of catgut, the uterus replaced, and finally the w'ound in the vagina closed. This method has given such excellent results that it should be resorted to as soon as elastic pressure by Aveling's method and manual taxis according to Noeggerath and Courty have failed. DISEASES OF THE UTERUS. 491 Amputation. — When all conservative measures fail, the tumor must be removed. The chief danger of this method is the possibility of the presence of the intestine in the inverted part. The mass may be removed by means of the f/alvano-caustie u-ire or Paquelin^s thermo-cautery. If reinversion of the stump should take place, the cut surface forms a hollow cone from which discharge can escape into the vagina. The tumor may also be cut away with knife and scissors, but then silver sutures should be drawn through the base before the ablation, so as to be able to close the peritoneal cavity. On each side one suture should be brought out transversely, so as to encircle the lateral blood- vessels, while three middle sutures bring the cut surfaces together. Destruction of the Mucous Membrane. — In irreducible cases in women near the climacteric, the dangers of amputation may sometimes be avoided by destroying the mucous membrane and producing cicatri- zation by means of potassa cum calce or the thermo-cautery. If inversion is produced by a fibroid, this must be removed before an attempt is made to reduce the inversion. It is sometimes difficult to find the line of demarkation. The safest is to make an incision over the end of the tumor and enucleate it with Thomas's serrated scoop (Fig. 290), which will be described in treating of fibroids. When once the tumor is removed, perhaps parts of the tissue in which it was imbedded have to be cut away. Next, the uterus is to be rein- verted and packed with iodoform gauze. •If the tumor is malignant, the whole uterus should be extirpated by vaginal hysterectomy, as detailed under Cancer of the Uterus. If we have to deal with a hollow polypus, it should be pulled down, which is best done by surrounding it with a noose. If there is any difficulty in applying it, a sling-carrier in the shape of a uterine sound with a small cresccint at the end will easily bring it up (Fig. 26.3, p. 455). A small incision is made in the pedicle, through which the sound is ])ass('d, and only enters to a depth corresponding to the size of the uterus. The diagnosis thus having l)een comj)leted, the protruding tissue is removed by the thermo-cautery or the gal- vano-caustic wire or knife or scissors, followed by a hemostatic running suture. I. Hernia Uteri. Hernia uteri, or hysterocele, is that displacement of the uterus in which it is found lying outside of the pelvis in a sac formed bv the peritoneum. The uterus has been found in an inc/uinal and in a n'ur(d hernia. Sucii cases are extremely rare. Thev are iiearlv always congenital malformations. (See p. 41.'}.) 492 DISEASES OF WOMEN. CHAPTER XIII. Neoplasms. A. Oysts of the Uterus; Adenoma Uteri; 3Iiicous Polypi ; Myxoma. In regard to cysts of the cervix and ovula, of Naboth we refer to what has been said above under Lacerated Cervix (pp. 396 and 318) and Chronic Endometritis (pp. 427 and 433). Tliese cysts, being formed by occluded glands, are a kind of adenoma. Cysts of the corpus uteri are very rare. Sometimes they are multi- ple. They are supposed to owe their origin to a detachment of the bottoms of uterine glands, or to be developments of Gartner's canal. (Compare Vaginal Cyst, p. 378.) In speaking of hyperplastic endometritis (p. 427) we have men- tioned another kind of adenomas, small benign tumors formed by a conglomeration of hyperplastic uterine glands. They may be sessile and do hardly ever become larger than a waliuit, but have a tendency to become pedunculated and form so-called glandular polypi. Such polypi start very frequently from the mucous membrane of the cervix, and hang out from the os, where sometimes they may acquire so con- siderable a size as to fill the vagina ; but that is rare. Most of them come under treatment when they are not larger than a cherry, a pigeon's Qg^, or a small oyster. They are soft, covered with a dark red mucous membrane. They are full of cavities, the contents of which are thin or thick, clear or dark. Sometimes the polypi are formed of myxomcdous tissue consisting of a delicate fibrous network, with slight thickening at the points of intersection, and a hyaline or finely granular mucoid basis sub- stance in the meshes, in which we find imbedded single or multiple granular corpuscles. Glandular formations are rare or absent.^ The name " adenoma " is also taken in a narrower sense, and used to designate a tumor formed by an exuberant growth of utricular glands, while the connective tissue between the epithelial tracts is extremely scanty and fibrous, only a small number of medullary cor- puscles being present. In contradistinction from this benign adenoma, some authors speak of a malignant adenoma, which is only the first stage of carcinoma. The microscopical aj^jiearance which characterizes it is described as follows : The gland-spaces are very much enlarged, very irregular, and are frequently seen to break through into other gland-spaces. The columnar epithelial cells are attached to the stroma, as a rule, and they are often converted into cuboidal or even squamous cells. These ^ Louis Heitzmann, "The Differential Diagnosis between Fungous Endometritis and Tumors of the Mucosa of the Uterus," Amer. Jour. Obst., Sept., 1887, vol. xx. p. 897. DISEASES OF THE UTERUS. 493 cells are frequently seen filling up a gland-space. They, however, never infiltrate the interstitial or stroma tissue. The neoplasm ex- tends to, and appears progressively to destroy, the muscular wall by atrophy or, perhaps, fatty degeneration. It persistently progresses as an atypical, glandular, epithelial type of disease.^ Fibrinous polypi are pedunculated growths formed by layers of fibrin deposited over a remnant of the after-birth left in the interior of the womb after childbirth or abortion. Symptoms. — ]\Iucous polypi cause hemorrhage, leucorrhea, sterility, and sometimes pelvic pain, backache, or dyspareunia. When situated above the internal os, they may work like a ball- valve and cause great dysmenorrhea. The treatment of mucous polypi and benign adenoma must begin with the removal of the growths. In the interior of the uterus this is done with the curette (p. 178). From the cervix they may be torn off by seizing them with forceps and turning the instrument until the j)edicle is severed (torsion). Or they may be cut off with scissors, but then it is well to have a thermo-cautery in readiness, as there may be some hemorrhage. They may also be removed with the galvano- caustic wire or a simple cold wire ecraseur. After removal of the growth the accompanying chronic endome- tritis should be treated as described above (pp. 432-435). Malignant adenoma is an indication for speedy hysterectomy. B. Cavernous Angioma of the Uterus. This neoplasm is very rare. It consists of a tumor formed of ectatic veins filled with blood. Patholof/ieal Anatomy. — The tumor varies in size from a hickory nut to an English walnut. It is situated in the muscular coat and covered with the endometrium and the peritoneum. The inner sur- face is nodular. The tumor is either spongy or harder than the sur- rounding uterine tissue. On incision the cut surface is covered with dark, fluid blood, and after this has been removed a delicate fram(>- wr)rk with thicker nodules appears. The cavities of the framework, which differ in size and intercomnuniicate, are filled with fluid blood. Th(^ framework consists of smooth muscle-fibers covered with fibrill.'o of connec'tive tissue with an endothelium. In some ])laees are seen outgrowths of connective tissue forming })a|)ill;e. The cavities of the tumor comnnmicate with the veins of the neighboihood. Ktiolo(jy. — TJie cause of the formation of uterine angioma is un- known. Perlia[)S it sometimes originates in a subinvolution of the placental site. ' II. I). Ik-yea, Amrr. .Jour. OliM., Feb., 189*!, vol. xxxiii. p. 200. 494 DISEASES OF WOMEN. Sj/mptoms. — This kind of tumor gives rise to recurrent and pro- fuse heniorrhatje. The diagnosis can only be made by microscopical examination of the scrapings obtained by curetting. Treatment. — Since this neoplasm may occupy the whole thickness of the uterine wall, curetting may lead to perforation. In the only case observed clinically, the uterus was removed by vaginal hysterectomy.^ C Uterine Fibroids ; Fibroid Polypi ; Fibro-cysts of the Uterus. Fibroid tumors, or fibroids of the uterus, fibromata, are more exactly called myomata — i. e. muscular tumors — or myofibromata, or fibro- myomata — names denoting a mixture of muscular and fibrous connec- tive tissue in their composition. Pathological Anatomy. — Fibroids are so common that they are found in the body of one out of every five women over thirty-five years of age. They are globular tumors composed of several nodules, and may attain enormous dimensions, weighing up to 140 pounds. They are mostly harder than normal uterine tissue, but may be so soft that they impart a sensation which cannot be distinguished from fluctuation. On the cut surface they appear white or pinkish, show an irregular concentric arrangement of the fibers around different centres, and bulge out beyond the surrounding parts. In most cases the tumor is separated from the uterine tissue by a layer of loose connective tissue, the so-called capsule, so that it is easily shelled out; but often this capsule is incomplete, and the tumor is a direct continua- tion of the surrounding muscular wall. As a rule, the substance is compact and contains less fluid than the surrounding tissue, but some- times it is full of dilated arteries, veins, or lymph-vessels {cavernous myoma, myoma teleangiectodes and lymphangiectodes). Generally the tumors themselves have scant blood-supj)ly, but are surrounded by a zone rich in arteries.^ Nerves can be followed into the interior; The uterus grows with the tumor, so that its cavity becomes larger ; as a rule, the muscular tissue becomes hyperplastic, and numerous blood-vessels are developed in it. But in exceptional cases the nor- mal muscular tissue nearly disappears, and the uterus forms only a mass of fibroids held together with a small quantity of connective tissue, as in the case represented in Fig. 283, or a bag filled with calcified tumors. Fibroids may be developed in the body or in the neck of the womb, but the cervical are much rarer than the corporeal. In non- > II. J. Boldt, AvKT. Jour. ObsL, Dec, 1893, vol. xxviii. pp. 834-846. Klob, Paiholnfjhche Anatnmie der weiblichen Sexualorgane, Wien, 1864, p. 173. 'J. (r. Clark, Johns Hopkins Hospital Bulletin, Marcli, 1899, No. 96. DISEASES OF THE UTERUS. 495 pregnant women only 5 per cent, are situated in the cervix ; in pregnant women 20 per cent, have this situation, the relative frequency in the state of gravidity being due to the fact that Fig. 283. rtonis in which all muscular tissue was replaced by connective tissue and fibroids, nine f)f which were enucleated before the uterus could be delivered : a, vaginal llaps; /), su]ira- vut,'inal liy pertrophied cervix ; c, body of uterus still full of fibroids ; d, vaginal portion.' o('rvi(;al fibroids are likely to cause serious complications of preg- nancy and childbirth, wiiich bring the patients under medical observation. They are either srssi/c or pedunculated, and the latter may either hang from the cervix and develop into the vagina, or spring ' I)r;iwinj( of specimen Iroin the writer'^ (ii)eratiua on ^Irs. li. iit 6t. Mark's IIoHpitul, .June 11, IHOS. 49G DISEASES OF WOMEN. from the interior of tiie corpus or fundus ; or they may spring from the outer surface of the corpus and fundus and develop into the peri- FiG. 284. Transition from Imbedded to Pedunculated Uterine Fibroid. Smooth right end free, the remainder imbedded.^ toneal cavity. Those which spring from the cervix and the uterus proper and are covered with mucous membrane are caUed fibroid polypi (compare glandular and fibrinous polypi, pp. 427 and 492, 493), the word " polypus " being used as a general term for any pedunculated tumor attaclied to a mucous membrane. Sometimes a fibroid may be partly imbedded in the uterine wall and partly form a polypus, thus forming a transition from a sessile to a pedunculated tumor (Fig, 284). Pedunculated Submucous Fibrous Tumor (fibroid polvpus) enclosed in Uterus (Cruveilhier) : F, fundus of uterus; 0,0, ovaries; L,L, round ligaments; C, cervix; U, vagina; P, polypus. Fibroids are called submucous (Fig. 285) when a part of them is only covered with mucous membrane; subperitoneal (Fig. 286) if they are partly situated immediately under the peritoneum; and interstitial or iy\tramural (Fig. 287), if they are surrounded by * Specimen from my operation on Mrs. S., March 24, 1894. DISEASES OF THE UTERUS 497 a layer of muscular tissue. This latter variety has a tendency Fig. 286. Pedunculated Subperitoneal Fibroid (Hofmeyer). to work its way outward or inward, so as to pass into one of Fig. 287. Intrniniiriil Fibroid ((iu.sscrow). the two other varieties, and may even become podiciilnte. :i2 498 DISEASES OF WOMEN. Sometimes there is only a single tumor, but quite frequently fibroids are multiple. In 'the latter case the uterus with its tu- mors may form a mass of fantastic shape, often reminding one of certain forms of cactuses (Fig. 288). Fig. 288. Large Cactus-shaped Uterus full of Fibroids.' If the fibroid is developed in the infravaginal part of the cervix, it may form a polypus attached to one of the lips, and from the upper part it may develop upward into the wall of the body or into its cavity or into the connective tissue of the parametrium, the broad ligaments, and the pelvis in general, separating the layers of the meso rectum. Microscopical examination shows that fibroids originate from round cells surrounding capillaries which are undergoing obliteration. The well-developed tumor consists of unstriped muscle-fibers, mixed with more or less fibrous connective tissue and fusiform cells. Fibroids are not so apt to be bound to the ])eritoneum of the abdominal wall or other organs as ovarian cysts, but if they do form such adhesions, these ai'e often broad and contain very large blood- vessels ; so much so that the tumor to a great extent derives its nour- ishment from the adhesions ; nay, in course of time it may be severed altogether from the uterus, and be found attached exclusivelv to an- other part of tiie abdomen. Such pediculate tumors may even be torn off from the uterus and lie loose in the abdomen as necrobiotic ma.s.ses, without fi)rming new adhesions. Fibroids are very fre- quently accompanied by local peritonitis, and may also cause cellu- * Specimen from my operation on Miss B. M., in St. Mark's Hospital, March 13. 1894. DISEASES OF THE UTERUS. 499 litis. They are often the cause of ascites, usually serous, sometimes chylous, and rarely bloody. Fibroids are apt to undergo changes in their constituent elements. Some of them soften and swell at each menstruation, and if they are pedunculated the tumor at that time may be driven out througii the cervical canal and appear in the vagina. After the menstrual period the swelling subsides, and the tumor recedes again into the interior of the womb, forming what is called an intermittent polypus. A similar softening and swelling take place on a larger scale during pregnancy, but, on the other hand, the tumor partakes of tlie geneml involution after the birth of the child, and may disappear entirely. Such disappearance has also been observed after inflammation or under circumstances where no simultaneous process could be sup- })osed to be the cause.^ And quite frequently fibroids remain of small dimensions and give rise to no symptoms during the bearer's whole life. After the menopause fibroids, as a rule, become smaller and harder, but they may continue growing. Even apart from menstruation and j)regnauey fibroids are apt to become edematous. Sometimes myxo- matous tissue is found in their interior. Cysts may be developed either by simple accumulation of serum in the meshes of the tumor, or by resorption of myxoid tissue, or by dilatation of lymph-spaces. The latter kind has an endothelial lin- ing.^ Often these cysts fii*st appear spread as small hollows, so-called c/eodes, throughout a fibroid, but subsequently the intervening tissue is al)sorbcd, and finally one large cyst is formed. Such cysts increase rapidly in size, and may become very large, twenty quarts having been evacuated from one. The Jiuid contained in fibro-cysts, as might be expected from their different nature, diffei-s very much. Sometimes it coagulates by exposure to tiie air, and more frequently it is a serous, non-coagulat- ing fluid. In small cysts it is citrine, viscid, or serous, but in larger cysts it contains more or less blood and becomes yellow, bloody, dark brown, or chocolate-colored. Sometimes the contents arc jiurulent. The fluid is alkaline, and coagulates entirely on boiling and with acids. It contains always much albuuiin, and sometimes fibrin. Tile microscope reveals sometimes detached unstriped muscle-cells from the surrouuding tissue. When a consid(!ra))le bloody extravasation takes place into the cyst, it may rupture, and the contents be poured into the peritoneal cavity. ' Doran, "On the Alworptioii of Fibroid Tumors of the Uterus," 7V((/i.s. Lon<l<>n Oh.il. S(>r., 1S'J:j, p. 2.')0. ' A specimen of this kind is desoril)ed in detail in (}arripucs's I)i(i()ii().ii.< of Ovtrinn Cifil-t hy Meaiui of the Etaminatiim of their Contents, V\'m. Wood & Co., New York, 1882, pp. 60-03. 500 DISEASES OF WOMEN. The fibroid may slough, either spontaneously or after operations or the use of ergot. In tiiis way a cure may be effected, but the patient may also succumb to septicemia. By deposit of calcareous matter in their interior fibroids may become calcified and form a stony mass. They may also undergo sarcomatous or carcinomaiaus degeneration. Etiology. — The causes of fibroids are unknown. The tumors are developed during the fruitful age of the woman. They are found more frequently in sterile women than in those who have borne chil- dren. Celibacy may perhaps predispose to their formation, but in most cases the sterility is probably the effect and not the cause of the fibroid. It is stated nearly everywhere that the negro race is more liable to fibroids than white people, but of late this has been denied by an American physician, who has had exceptional opportunities for personal observation of the fact.^ Symptoms. — Fibroids, especially polypi and the submucous variety, cause menorriiagia (p, 262) and metrorrhagia (p. 264), leucorrhea (p. 268), hydrorrhea (p. 430), and pain. The bleeding is partly of venous origin, the tumor causing stasis in the veins of the endometrium ; and partly it is arterial, the arteries between the tumor and the en- dometrium changing their direction from one perpendicular to the endometrium (p. 59) to one parallel Avith it, and giving off twigs at right angles to the endometrium. The mucosa itself atrophies, and finally disappears over a large area, laying bare the capsule of the myoma. The blood-vessels themselves undergo changes which lead to the occlusion of some, to the widening of others, and to the rendering of their loops brittle.^ The pain may be located in the abdomen, and be due to accompanying peritonitis, to the distension of the abdominal wall, or to the weight of the tumor. By pressure on the sacral plexus severe neuralgia may be caused in the pelvis, and shoot down through the legs. A polypus that is being expelled through the cervix gives rise to " cramps" or labor-like pain. The circumference of the abdomen may increase enormously. A tumor is felt entering the vagina, from the uterus, or imbedded in the uterine wall, or extending from it into the peritoneal cavity or into the broad ligaments or the pelvic floor. If it is a solid fibroid, it is generally more or less hard, globular, nodular, but may be quite soft, as we have seen in the anatomical descri})tion. If it is a fibro-cystic tumor with large cysts, it is fluctuating. The presence of the tumor may oppose an obstacle to micturition or make it frequent. If it presses on the ureters, it may cause pye- litis and hydronephrosis. By pressing on the rectum it may be the J Middleton Michel of Charleston, S. C, Mexl. News^. Oct. 8, 1892. * J. G. Clark, "Tlie Cause and Sifrnificance of Uterine Ilemorrliajje in Cases of Myoma Uteri," Johns Hopkins Hospital Bulletin, Nos. 94-90, Jan. -Mar., 1899. DISEASES OF THE UTERUS. 501 cause of constipation and hemorrhoids. The presence of the tumor may interfere with the free circulation of the blood, causing edema, ascites, dilatation of the heart, or myocarditis. It may push the uterus down and cause prolapse (p. 478). If attached to the fundus, a fibroid polypus in descending may drag the uterus along and cause inversion (p. 485). In rare cases it produces diastasis of the linea alba, and lies partly in a ventral hernia. By pressure on the uterine vessels, fibroids may cause a sound like the uterine souffle of preg- nancy, and in very rare cases a thrill like an aneurism. The intraligamentous variety forms a tumor in the iliac fossa ; that in the pelvic floor may be traced to the cervix. Diagnosis. — In most cases the diagnosis is easy, but it may be very difficult or impossible. From hemorrhagic metritis sessile fibroids differ by the presence of a tumor, which can be felt imbedded in the wall. A polypus in the vagina is felt with the finger ; in the interior of the womb with the sound or, after dilatation (p. 156), with the finger. One examination, at least, ought to be made at the time of menstruation, since we have seen that the so-called intermit- tent polypus at that time becomes accessible to touch, and may be seen through a speculum. In cancer of the cervix soft masses can be scraped off" with the nail. There soon appears a hard ring around it ; it ulcerates at au early date; and the discharge has au offensive odor. Cancer of the body gives rise to greater pain than a fibroid ; the constitution suffers much more and sooner ; the jwtient becomes emaciated, the skin has an ashy-yellowish color, while those affected with fibroids preserve for many years a florid hue and are in fairly good health. The lymphatic glands corresponding to the part affected with cancer be- come infiltrated. Ascites is more common with cancer, and a bloody ascitic fluid is nearly always associated with malignant disease. A sloughing fibroid polypus may resemble an epitheliomatous growth of the cervix, but the microscopical examination shows an entirely different structure. A fibroid polypus is distinguished from a glandular by its hardness. It may not be possible to differentiate it from a fibrinous po/i/pus until it has been removed and examined microscopically, but the fact that the trouble has begun after childbirth or abortion would make it likely to be the fibrinous variety. A fibroid in the posterior wall may from the vagina feel like a retroflcxiov , but l)y bimanual examination the funihis may be felt turned forward, or the direction of the uterine canal may be ascer- tained with the sound, and the greater tliickness of the same between the sound and the ])osterior fornix of the vagina may be felt. A fibroid in the anterior wall may i)e taken for an antcjicxion, but the diagnosis is made by judging of tiie thickness of the wall between the sound and the anterior fornix of the vagina. 502 DISEASES OF WOMEN. A ntenis bicornis may be taken for a single uterus with a fibroid, but the contour is more regular, the consistency normal, and the sound can be introduced into both horns. In regard to the often difficult and very important differential dia- gnosis between polypus and inversion of the uterus the reader is referred to what has been said above (p. 487). Another diagnostic feature of the utmost importance is the distinc- tion between a sessile fibroid and pregnancy. As a rule, menstruation stops in the latter, while in tlie former it goes on, or is even increased in regard to the amount of the secreted blood and the duration of the discharge. The development of the swelling is regular and more rapid in pregnancy, k^oftening of the cervix and lower uterine segment, fluctuation, ballottement, and recognizable parts of the fetus are felt. The fetal heart may be heard, and fetal movements both felt aud heard. The mammary and stomachal signs of pregnancy are not found in connection with fibroids. In hydramnion we have besides the history of pregnancy an open cervical canal, through which the ovum can be touched. Fibroid tumors may be combined with pregnancy, and the detection of such a condition may be of great practical importance in regard to treatment. A suspicion of such a condition should always be awak- ened by hemorrhages during pregnancy. The sound is, of course, not available. The physician must rely on the history, the stethoscope, and a careful palpation. A small subperitoneal fibroid may form a tumor somewhat like that formed by swollen appendages adherent to the uterus, but, as a rule, the latter swelling will be softer and much more tender, and the ute- rine cavity is not enlarged. Accompanying peritonitis may, however, make a fibroid quite tender, and, on the other hand, old inflammatory masses around the appendages may form a very hard tumor. Before making any diagnosis of abdominal tumors the physician should be sure to have the bowels well emptied with aperients and enemata, and the urine drawn with a catheter. Otherwise he might be deceived by scyhcda or a full bladder. A pedunculated subperitoneal fibroid may be so like a solid ovarian tumor that the distinction becomes impossible, and the same holds gootl in regard to the diagnosis between a fibro-cyst and a multilocular ovarian cyst. In trying to differentiate them the following points should be considered. Fibro-cysts are rather rare ; ovarian cysts common. Fibro-cysts are seldom found in women under thirty-five years of age ; ovarian cysts are frequent in young persons. Fibro- cysts develop more slowly. Patients with fibro-cysts preserve long a good general health and have a florid face, while in those with a mul- tilocular ovarian cyst the constitution soon suffers. With a fibro-cyst the abdominal veins rarely become dilated ; with an ovarian cyst it is DISEASES OF THE UTERUS. 503 quite common. Hard masses are felt above the fibro-cyst ; in ovarian cysts they are found nearer the base if at all. A fibro-cyst draws the uterus up ; an ovarian cyst pushes it down and backward or forward. With a fibro-cyst the uterine cavity becomes often considerably elongated ; with an ovarian cyst it remains of normal length or is only slightly deepened. By means of the sound it may be possible to move the uterus independently of an ovarian tumor, while a fibro-cyst follows the movements of the uterus. Ascites is more com- monly found with fibro-cysts than with ovarian cysts. Now-a-days we avoid aspiration and tapping, but if for some reason one of these operations has been resorted to, coagulability of the fluid and the presence of muscle-cells in it militate strongly in favor of a fibro-cyst, while the presence of numerous small round bodies with several shining granules speaks as strongly in favor of an ovarian cyst.^ Fibro-cysts of the uterus can only be distinguished from fibro-cysts of (he ovary by the circumstance that the former move with the uterus, while the latter may be movable independently. The fluid is identical. Myomas of the knr/e intestine have in a few cases reached con- siderable size, and may be much like uterine tumors of the same kind; but as a rule it is possible, at least under anesthesia, to find that they are not connected with the uterus.^ In plain ascites there is a swollen, fluctuating abdomen, but no tumor. In ascites combined with a fibroid the tumor is felt on dis- placing tlie fluid. Iloiiatoccle and exudative peritonitis are acute diseases with a sudden start. Prognosis. — The majority of fibroids give rise to no symptoms and are harmless. They are in themselves benign, but may endanger life in different ways. After the menopause their development is, as a rule, arrested ; tiiey begin to shrink and the ])atient suffers less; but, on the other hand, tlie change of life is often postponed in women affl'cted with fibroids, and some fibroids continue gnnving, jnirsue a more disastrous course than before, and frequently become cystic, calcareous, or have abscesses develop in them.* A spontaneous cure may occasionally be effected by involution after pregnancy or by expulsion of a })olyj)us. Hemorrhage' rarely l)e<'omes directly fatal, but through the repeated losses of blood and the drain caused by leucorrhea the constitution finally suffers. Pain, worry, and disturbed sleep iiave a similar effect. Meciianiciilly, the tumor may cjiuse death by closing the ureters or the intestine. The heart sufftTS in consequence of the increase<l work • Exceptions are treated of in my al)<)ve-nanie(l work on Ovarian C>isl.^, pp. G3 G7. 'Richard Krukeiiliern, ('iiilralhl. f. (ii/niik:, 1S97, No. '(2, vol. x.xi. j). i.')l"). 'Joseph Taher .Johnson of \Va.shin<,'ton, I>. C, "(Jrowth of Filiroids after tlie Menopause," Amer. .Jour. (M)M., l)ec., IS'JI, vol. xxiv. p. M'JO. 504 DISEASES OF WOMEN. thrown upon it. Large tumoi-s press on lungs and liver, interfering with respiration and digestion. The tumor itself has some tendency to sarcomatous or carcinomatous degeneration. The peritoneum becomes the seat of chronic inflam- mation, and sometimes papillomatous degeneration. In rare cases a fibroid becomes the cause of embolism and paralysis. For the treatment of these tumors sometimes operations are required that belong to the most difficult and most hazardous. Treatment. — In treating a case of fibroid tumor of the uterus the therapeutical resources at our command should, in the opinion of the writer, be considered in the following order : Cut off polypi ; Tie and cut pedunculated subperitoneal tumors ; Lift tumor ; Hemostatic and anticatarrhal remedies ; Galvano-chemical cauterization ; Curetting ; Vaginal enucleation ; Ligation of ovarian and uterine arteries ; Abdominal enucleation — (a) from the uterine wall ; (6) from the broad ligament ; (c) from the pelvic floor ; Supravaginal amputation — (a) with retroperitoneal treatment of the pedicle ; (6) with extraperitoneal fixation of the stump ; Total extirpation of the uterus. Fig. 289. Tape-carrier. For a polypus there is no other treatment than to remove it as soon as possible. If it lies in the vagina, this is a very simple matter. The anesthetized patient is placed in the dorsal position, the legs fast- ened with Robb's leg-holder (p. 208), the vagina disinfected, the tumor brought into view with s])eculum and retractors, the cervix dilated with a steel dilator, the tumor seized with a volsella and pulled down, M'hile an assistant pre.s,ses on the fundus uteri. If the tumor is not very small, a better hold of it is secured by passing the noose of a linen tape around it above the volsella. If necessary, the tape may be pushed up by means of a crutch, an instrument exactly like a uterine sound ending in a little fork (Fig. 289). This loop allows us to pull DISEASES OF THE UTERUS. 505 the polypus considerably down, and its pedicle is cut oiF with a few rotary movements of Thomas's spoon-saw (Fig. 290), a shallow spoon Fig. 290. Thomas's Spoon-saw. with dull serrated margin.^ The pedicle may be cut near the tumor, and it is safer to do so. Subsequently the stump is drawn into the substance of the uterus and disappears. If the polypus is situated in the interior of the yet closed uterus, the cervix must first be dilated with aseptic laminaria (p. 156) or iodoforraed cotton balls (p. 159). If it spring from the fundus, a pair of strongly curved scissors may be needed for removing it (Fig. 291). Fig. 291. Bozeman's Double-curved Scissors. An intermittent polypus should be removed during menstruation, when it can be seized in the vagina. Very large polypi may be brought out, after the pedicle is severed, by means of the obstetric forceps. Wedge-shaped pieces may be cut out of the lower part of the tumor in order to make it smaller, a pro- cedure called marcel lation^; or a sj)iral incision may be carried around it, right into its substance, while it is being pulled down, which is called allongement. As there often are other fibroids imbedded in the uterine wall, which in c»nrse of time become jK'dunculate, the operation may have to be rejx;ated, although it is radical in regard to tiie tumor it is ap})lied to. .Subperitoneal tumors ciui only be I'cached by laparotomy (see Ova- riotomy). If they have a well-developed pedicle, it should be trans- ' Many instrurnent-niakcrs make it too liollow and witli too .Hliarp teetli, wliicli clwiiitfes it from a .safe and vaiiuihlc iiistrmiK'iit into a (ianu'iTous otie. ' I removed in tliis way a tiiiroid weifrhintr twenty-eiL;Iif ounces, from the ntiTiis of Mrs. M., in St. Mark's Hospital, on Dec. 1<), l.sys. 2>'eue I'Drken DU'dicinischc Monataachrift, vol. xi. No. .'!, p. r.'o, March, 1899. 506 DISEASES OF WOMEN. fixetl, and a double silk ligature of proportionate strength drawn through and cut into two halves, which are made to cross one another so as to form two interlocked loops, each of which is tied on opposite sides (Fig. 286). Tlie object in dealing with the pedicle in this way is to prevent the ligature from slipping, which may cause fatal hem- orrhage. Great relief from pressure on rectum, bladder, or nerves, or from pulling on ligaments, may be afforded by lifting the tumor up, and sometimes it may be prevented from falling down again by a pessary, such as a large-sized Gehrung's (Fig. 266, p. 456) or Thomas's (Fig. 264, p. 455), or an abdominal belt with vaginal cup (Fig. 277^ p. 480). Medical Treatment. — Alone or as an adjuvant to other measures medicinal treatment is of considerable value in combating symptoms, and may even occasionally effect a radical cure. The chief symptoms that call for medicinal treatment are hemorrhage and leucorrhea, and we refer to what has been said on this subject in the general part under Hemostatics (p. 243), Menorrhagia (p. 262), and Leucorrhea (p. 268). The writer would particularly call attention to the value of gossypium for combating hemorrhage and pain. Ergot may be given by the mouth, in suppositories (extr. ergotse, gr. ij-v in each, one, two, or three times a day), or hypodermically. For the latter purpose ergotin (gr. ij or iij) or sclerotinic acid (gr. f) is preferred. Some years ago, before the Apostoli treatment was introduced, I used such injections and saw good effect from them. The formula was R. Acidi sclerotinici, gr. x ; Glycerini, 3ss ; Aq. dest. q. s. ad 3ij. M. Sig. Eight minims hypodermically. The injections are made in the abdominal wall in front of the tumor, and they should be very deej). The syringe must be clean and the skin made aseptic. By so doing I have never seen an abscess form, but each injection is accompanied by considerable pain, redness, and swelling, and leaves a knob slow to disappear. The injections were repeated three times a week. This treatment has afforded such good results in the hands of many observers besides myself, leading even in some cases to the total disappearance of the tumor, that under circumstances it is well worth trying. As a rule, the method is safe. Too large doses of ergot have, however, caused symptoms of pois- oning; and a case has been reported in which the tumor became gangrenous, and the patient died of septicemia.' Instead of sclerotinic acid, ergotin (gr. iij pro dosi) may be used dissolved in five parts of water : » W. T. Lusk, N. Y. Med. Jour., July, 1882, vol. xxxvi. p. 30. DISEASES OF THE UTERUS. 507 I^. Ergotini (Squibb), Hss; Aq. dest., Sijss ; Acid, carbol., TTLij. M. Sig. Eighteen minims for each injection. To inject ergot preparations into the substance of the uterus is dangerous and oifers no advantage. Desiccated mammary gland of sheep, three to six tablets a day, each containing two grains of the dry gland powder, is praised. Under its influence the tumors are said to decrease, hemorrhage to stop, and the general health to improve.^ Compare p. 245. Among mineral watei-s, Kreutznach, used both internally and in fomentations and baths, has the best reputation for its effect on fibroids. With the exception of polypi, pedunculate subperitoneal fibroids and fibrocysts, most other fibroids should, if possible, be treated with galvano-c.hemical cauterization after Apostoli's method (p. 250). In cases of hemorrhage and leucorrhea the positive pole is used in the uterus; in more dry cases the negative. If the electrode can be intro- duced into the canal, there is hardly any danger. I even allow the patient to go home by street-car and elevated railroads immediately after the application, which I prefer to make in the office, where more perfect apparatus is available. The first effect is to assuage pain, which gains the patient's confidence. In the vast majority of cases the tumor will become smaller, and in some it disappears. Hemor- rhage will nearly always cease. The softer the tumor is — that is to say, the less connective tissue and the more serum are contained in the muscular bundles — the better are the prospects. In some cases I have seen parts of the tumor gradually pushed out, so as to form prominences in the peritoneal cavity. The method is compara- tively safe and promises so much, and, on the other hand, most of the cutting operations are so dangerous, that, as a rule, electricity should be given a fair trial before resorting to the latter.'' The method is, however, not devoid of danger. Sometimes local peri- tonitis may follow the application, and some uteri are so distorted by the fibroids they contain that some j)laces of the wall may be- come very thin, li it should happen that the intra-uterine elec- trode were applied to such a place, the cauterization might go through the whole tiiickness of the wall. Many ])atients cannot get the tedious galvanic treatment, and, ^ J. B. Hhoher of I'iiiladelpliia, Tnins. Amer. Gpier/d. Sf>c., 1898, vol. xxiii. p. 204. 'ThorTi;i.s Keith, wIk) in his time was by far more successful than all ('oiitempo- raneous operators, strongly reconirnciHicd Apostoli's method (" ( outriljutions to tlie 8urj(ical Treatment of Tumors of the Al)domen," I'art II,, Klcrtririttj in the TratlmnU Ulerinr Tumorfy I']<linhurgh, 1889, p. viii.). Only wlien the tjalvanic treatment led did he perform hysterectomy {(lynccoL Traris., 1890, vol. xv. p. 148). of U ftiilec: 608 DISEASES OF WOMEN. moreover, the experience of later years has shown that by operating early the prognosis for the operation — like that for ovariotomy — has become much bettor. Hemorrliage may be checked by curetting (p. 180). Perhaps it gives relief only for some months, but may then be repeated. By thus scraping off the endometrium with its dilated veins the patient may sometimes be kept alive until the menopause arrives and brings permanent relief.^ Properly performed, the operation is, as a rule, harmless ; the writer has, however, had a case in which it was fol- lowed by gangrene.^ Vaginal Enucleation by 3Ieans of the Spoon-saw. — Large sessile my- omas, weighing up to three pounds,^ have been successfully removed through the vagina. The method is applicable to both cervical and corporeal fibroids. The patient is placed in Sims's position, and the largest Sims speculum is introduced. If the cervix is partially open, and the tumor offers a free end near it, the cervix is seized with a tenaculum-forceps and severed bilaterally up to the vaginal vault. A volsella is fixed in the lower end of the growth, and the uterine attachments severed with the spoon-saw. The cavity should next be washed out with disinfectant fluid and packed with iodoform gauze (p. 185). If the cervix is open and the tumor entirely imbedded in the wall of the body or situated in the cervix, a strong tenaculum is plunged into it, and a hole is cut with scissors in the lowest part of the pre- senting mucous membrane covering the tumor. This is extended on a director, the mucous membrane detached with the finger, a vol- sella fastened in the white tissue of the myoma, and the spoon-saw introduced and swept all around, detaching the tumor from its uterine bed for about an inch and a half or two inches, while traction is kept up. If the tumor is too large to be dragged dowu as a whole, it is removed piecemeal. For this purpose pieces large as hen's eggs are cut out, one after the other, from the detached part of the tumor. Then the tumor is again seized with the volsella, a new zone de- tached and removed piecemeal in the same way, and so forth until the remainder can be removed with the spoon-saw in one piece. It is only the first incision that is accompanied by serious hemorrhage ; the tumor itself has few vessels, and the spoon-saw with its blunt serrated edge peels it out from its bed without much bleeding. If the cervix is closed, it must be thoroughly dilated before enu- ^ An instructive paper on this subject was published by Henrv C. Coe in The Med- ical Record, Jan. 28, 1888. ' The patient recovered, and was radically cured, but another time the result might be less favorable. 1 scraped away what I could with the finger, tore dead shreds off with forceps, and used carbolized intrauterine and vaginal injections. ' Thomas, Amer. Jour. Med. Sc, April, 1880, vol. Ixxix. p. 405 ; Munde, Amer. Jour. ObsL, 1885, vol. xviii. p. 189. DISEASES OF THE UTERUS. 509 cleation is begun. For this purpose it is split up to the vaginal junction with Kuchenmeister's scissors, and the internal os incised bilaterally with Simpson's metrotome (p. 443), until all resistance is overcome, and finally full dilatation is obtained by using tents or cotton balls impregnated with iodoform, procedures which take days and weeks, and during which I more than once have seen the patients succumb to septicemia. The danger from septicemia after the operation is also considerable. Greater than the danger from hemorrhage or septicemia is that of perforating the uterus. It is impossible to know if the tumor has more than a peritoneal covering. At all events, the spoon-saw must be kept close up to the tumor. In pulling the uterus down it may become inverted (p. 491), and the inverted part must be replaced as soon as the fibroid is enucleated. In fact, the dangers are so great that this method cannot be recommended for entirely imbedded tumors, but for partially polypoid fibroids I think it is less danger- ous than oophorectomy and hysterectomy, and unlike them it pre- serves the possibility of impregnation. In exceptional cases, the fibroid starting from the posterior surface of the uterus presses against the vagina, and may be enucleated through an incision there. Kmmeffi Traction Method is, in some respects, like the preceding method of enucleation, but the capsule is never opened, and all is done in the vagina, not in the interior of the uterus. The tumor is seized with a volsella, ])ulled down, and removed piecemeal as it emerges from tlie os. In this way muscular contraction is induced, and the surrounding tissue gradually closes ujwn the removed tumor, so that it becomes jx'dunculate and leaves only a small raw surface. Ligation of Blood -rc.^^cln. — I^igation of both uterine arteries from the vagina (Franldin Marti n^x nnfliod, ■\). 1H8) has given good re- sults, both MS to hemorrhage and shrinkage of the tumor.' (loelet isolat<'s the artery, seizes it with a long pressnre-foree])s, ties it with stroiiir e:itti:nt outside and inside of this forceps, re- moves the forceps, and cuts the artery between the liiratures. The peritoneal cavity is not entered.^ 'I'his nu'thod, nlthoiiLih the trunk of" the uterine artery is cut, is less effective than I^'ranklin M;irtin's, because there are side; branches iroinsi; off from the uterine artery, which would facilitate the formation of a collnteral circnhition. Perhaps th'' nerx'c-siipply is also of some importance. It is, there- fore, better to tie the whole jtaramctrium by a mass ligature. ' I-'ranklin Martin of ( liicatro, Amrr. Jonr. ()h^l„ Apr., IS'.i:], vdl. xxvii. |)p. 481 40'J ; ihitlnii, .]:\n., IH'.ll. vol. xxix. pp. li'J-.''?. Nortli Ainrrirnn I'rddiliimrr, isy4, veil. vi. pp. -") 14; .I'Kir. Avirr. Mril. Afivtr., 1S94, vol, xxiii. pf). '21.'>-217. ' .\. H. (loolot, Avwr. (Jyn. and Obgt. Jour., Kel)., IH'.tT. 510 DISEASES OF WO 31 EN. C. C. Frederick ' of Buffalo reports good results, especially enormous shrinkage of the uterus, by tying the uterine arteries either from the vagina or after laparotomy. Others have tied the ovarian blood-vessels, and Rydygier^all six arteries supplying the uterus with blood, and yet the hemorrhage returned after ten months. In such a case the uterus and its tumor are supplied with blood through other normal arteries — the anterior and posterior azygos, or the middle hemorrhoidal (p. 60) — or through new-formed arterial connections imbedded in adhesions. The ligation of the uterine arteries from the vagina seems to be worthy of more attention than it has received. It is particularly applicable if the uterus does not rise much above the umbilicus, and in women who have born chil- FiG. 292. Segond's Speculum : a, anterior blade ; b, posterior blade. dren. It is safe, and, if it fails, it in no way interferes with a fol- lowing hysterectomy. Hysterectomy, may be performed through the vagina — vaginal Jiy.s- terectomy — or through the abdominal wall — abdominal hystei'ectomy. Vaginal hysterectomy may be performed with pressure-forceps, ligatures, or without either. Modus Operandi. — Clamp 3fethod, or l-'ean's Operation. — The pa- tient lies on her back, the legs held up with a suitable leg-holder (p. 207). The lower end of the table is raised about four inches. The exter- nal genitals having been shaved and disinfected, and the vagina ^ Amer. Jour. Obst,, Sept., 189o, vol. xxxii. p. 348. ^Cenlralbl./. Gyndk., 1894, vol. xviii. p. 297. DISEASES OF THE UTERUS. 511 disinfected (p. 207), Garrigues' self-retaining weight speculnm (Fig. 192, p, 226) is introduced, and depresses the posterior wall of the vulva and vagina, or this is done with a univalve speculum held by an assistant (Fig. 292, 6). The anterior wall is held up with a short, broad, univalve speculum (Fig. 292, a). The cervix is seized laterally with a bullet-forceps and dilated. The uterus is curetted and wiped with sterilized gauze wound around a pair of forceps, or, better, dis- infected by means of vaporization (p. 187). Next, a four-pronged traction-forceps (Fig. 197, p. 228) is inserted in the middle of the posterior lip and another opposite to it in the anterior lip. With these the cervix is moved up and down so as to show tlic utero- vaginal junction. Tiie cervix is then drawn forward toward the symphysis, exposing the posterior cul-de-sac well. A transverse incision is made with a scalpel at the utero-vaginal junction, about an inch above the end of the vaginal portion. Next, the cervix is drawn back and a similar incision is made in front, just below the bladder, about half an inch above the end of the vaginal portion. This is carried round the cervix till it merges in the posterior in- cision, the two forming one circular incision close up to the cervix. Next, a transverse incision, two-thirds of an inch long, is made on both sides corresponding to the transverse diameter of the os, and carried through the mucous membrane so as to unite at right angles with the circular incision. This enables the operator to make a larger anterior flap and carry the bladder and ureters well out of the way. It is used in all vaginal hysterectomies in which the cervix is small or the uterus large. Once the incisions are made, the operator pulls steadily down on the cervical volsella, cutting with small nicks of scissors and using the nails of his thumb and forefinger as much as possible. Behind, the peritoneal cavity is soon reached, and the opening is enlarged by pulling the peritoneum apart from side to side with the two forefingers, wiiile the posterior speculum is temporarily removed. This posterior opening is large enough to admit two or three fingers. In front the operator ])roceeds in a similar way, exposing as much of the uterus as he can and without paying any attention to tlie peritoneum. On the sides he can push up the parametria almost without cutting until he is near the broad ligament. No retractor should (!ver he inserted between the bladchn* and the uterus, as it draws the ureters together and might wound them or the bladd(>r. It siioidd only be iield flat against the mons Veneris, at right angles to the uterus, and push the bladder up. So far no attention whatsoever is paid to hemostasis, but when the operator has proceeded in front as far as he can and on the sides is nearly tiirough the parametrium, he places a pair of strong hemo- statics forc(>j)s (Fig. 29.'>) on the lower part of the broad ligament on i)oth sides, inchiding the uterine artery. The forceps is j)ut on in 512 DISEASES OF WOMEN. a peculiar way. The operator holds it close up to the cervix, holds the open jaws in front and behind the uterus and moves the point outward, describing part of a circle, by which he is sure to push the Fig. 293. Long Pressure-forceps, closing from point backward, bladder and ureter out of the way before he clamps the artery. Next, he closes the forceps just outside the uterus and cuts with scissors the tissue close up to the clamps and near up to their end, which makes the nterus much more mobile. The posterior speculum is then removed for good. The anterior wall of the uterus is pulled doM'n. As soon as feasible the uterus is anteflexed and the fundus brought into the wound, for which purpose, as a rule, the uterus is incised or pieces cut out of it, which procedure presently will be described. The adnexa are pulled out into the wound, if necessary after loosening adhesions with two fingers introduced into the pelvis. This is the only step that is done by feeling alone ; otherwise all is done in the wound under the control of the eye. AVhen the appendages of the left side are brought out, a pair of hemostatic forceps are placed from above over the broad ligament, outside of the appen- dages, and brought in contact with the forceps compressing the lower part of the ligament. This compresses the ovarian vessels in the infundibulo-pelvic ligament. The uterus is then cut loose on this side, and the broad ligament of the other side is clamped and cut in a similar way. If there is any bleeding from tlie cut surface, another clamp is placed outside of the first and this one removed. Thus, in a typical case, only four clamps will be left in the vagina, but if needed more are added. When the uterus has been removed, the operator should look carefully for any bleeding. For this pur- pose a pair of Pean's long narrow retractors, so-called ecarteurs, are introduced, one in front aud one behind, by means of which a view is obtained deep into the abdominal cavity, so that even the appendix vermiformis of the caecum may become visible. These retractors are much like Schroeder's (Fig. 193, p. 227), but longer and broader, the blade measuring five by one and a quarter inches. In searching for bleeding points, real sponges as large as hens' eggs, on account of their great porosity, are preferable to gauze pads. DISEASES OF THE UTERUS. 513 When all bleeding points have been secured, the wound is tamponed with long strips of dry sterilized gauze. Each strip is a quarter of a yard wide and several yards long. It is folded in several layers lengthwise, so as to be about two inches wide, and this pad is again folded transversely in zigzag at the top, and carried in just beyond the jaws of the clamps. If there is any suppuration, iodoform gauze is used instead of sterilized gauze. The vagina is packed loosely out- side of the handles of the clamps with iodoform gauze. For safety's sake the rings of each forceps may be tied together separately. The handles are surrounded with absorbent cotton held together with a string. A self-retaining soft-rubber catheter (Fig. 294) is left in the Fig. 294. Petzer's Self-retaining Soft-rubber Catheter: a, bulb; 6, flange. bladder and closed with a small pressure-forceps. It is introduced by entering a uterine sound through the central opening of the bulb A, and pressing it up against a point in the periphery. The bladder is emptied every two hours. The clamps as well as the surrounding dressing are removed forty- eight hours after the operation. If there is no fever, the pelvic tam- pon is left in for six or eight days. It becomes very offensive, but is removed more easily than at an earlier date. If the patient be- comes feverish, the j)aeking is removed at once. If the omentum sinks down, either during the operation or after removal of the tam])on, it must be pushed high up with a sponge or pad on a holder, so as to prevent its agglutination to the wound. If the intestine is adherent to the uterus, a reasonable amount of adhesive tissue should be left on it to go off by suppuration. The abdominal tampon is removed gradually by pulling down and cutting olf a piece every day.' Lif/aturc Mrfhod, or Schrocdo^s Oj)rr(d!on. — If we want to use ligatures, the two transverse incisions in the vagina are not united, l)ut a bridge, half an inch wide and two-thirds of an inch long, is left on each side of the cervix. The ])()steri(>r cul-de-sac is ojxiied as descrii)ed nbove. As soon :is the peritoneum of the utero-vesical pouch is reached, it is incised and torn from side to side, so tiiat we liave one opening behind and one in front of the uterus. The parametriinn on the left side is surrounded witii a strong 'The operation hero (iewrilwd is in all t>Hsentials that of Dr. Paul Sofroiid of Paris, an adherent of I'i'an, who was the inventor of vaginal liysterectoiny hy the clamp nieth(Kl. 33 514 DISEASES OF WOMEN. lifjaturc carried with a half-blunt handled needle, bent to the side (Fig. 295). After having cut the tissue between the ligature and KiG. 295. Schroeder's Needle. the uterus, another ligature is carried over the tissue situated above that comprised in the first ligature. Next, similar ligatures are placed on the right parametrium, which is also cut. Then we return to the left side, tying and cutting until the whole broad ligament has been tied in small portions, which, when tightened, ought not to exceed the thickness of a lead pencil. The application of tlie upper liga- tures is very much facilitated by throwing a strong silk thread over the ligament by means of J. B. Hunter's needle, which is constructed on the principles of Bellocq's tube for plugging the posterior nares. If po.ssible, the tube and ovary should be drawn inside of the upper- most ligature, or they may be tied separately and removed (see below). When the left side of the uterus is free, the right broad ligament with the appendages becomes much more ea.sy to handle, and is se- cured with a few ligatures passed from above downward. In regard to the material to be used for the ligatures tastes differ. If silk is used, the threads should be left long, and pulled out when they become loose, or they may be removed any time after two days 1)V using the ingenious device of Dr. (irad.' For each ligature two or three traction strings, strong silk loops marked with one, two, or three knots respectively, so as to be able to distinguish them from one another, are used. One of these strings is inserted in each loop of the knot, and by pulling on them each can be opened at the time the ligature is to be removed. If catgut is used, which is just as well in other respects, it is cut short, aiul is expelled together with the tissue forming the button of the ligature during the healing process. If there is hi'inorrhage from the cut surface of the parametrium behind or in front of the cervix, it may be ciiecked by uniting the edge of the peritoneum with tliat of the mucous membrane of the vagina. If there is still any bleeding from the dej)th, it may be checked by means of a Mikulicz tampon (p. 186). Otherwise the opening at the top of the vagina and the vagina itself are only parked loosely with iodoform gauze. * Herman Grad of New York, Amer. Gynec. and Obst. Join:, Feb., 1897. DISEASES OF THE UTERUS. 515 Some go a step farther and close the whole wound, drawing the stumj)s of the broad ligaments into the vagina. This makes recovery- speedier, avoids the disagreeable odor of decaying tissue, and prevents prolapse of the vagina, but makes the ojieration more difficult and tedious. It has been stated above, how the appendages should be removed ; but if the ovaries are healthy, it is better to leave them ; and the same rule applies to one of them, if that is healthy and the othc diseased. This rule has been evolved from observation of the mani- fold and serious disturbances following double oophorectomy (see J^csults of Salpingo-oophorcctomy), while single hysterectomy is tolerated much better. This rule does not, however, ap}>ly to cases of carcinoma of the uterus, because the ovaries are very liable to be involved in the cancerous degeneration. Comparison between Ligatures and Forceps. — Whetlier a surgeon will prefer ligatures or forceps depends often more on personal predi- lection and aptitude than on anything else. Forcejis may be applied at a depth whore ligatures cannot be ap])lied and where there is not tissue enough to form a button. The application takes less time, and is perfectly safe unless impatient and reckless operators remove the forceps too soon. If, however, a serious hemorrhage occurs after the vagina is partially filled with forceps, it may be very difficult to check it. The removal of forceps and of the pelvic packing is very pain- ful. Great care nuist be taken to avoid ])ressure-uecrosis of the vulva from forceps. In certain operations, such as those for large fibroids and for extensive pelvic inflammation, forceps alone are available. Often it is an advantage to combine both methods, and not to bind one's self stubbornly to either of them. Esj)ecially, it is sometimes an advantage to use ligatures for the easily accessible parametria, which leaves more room for the following manipulations of the uterus and ligaments. jrorcelldtioti. — If the uterus is too large to be removed in one piece, at least with preservation of its shape, recourse may be had to morcel- lation. In its sim[)lest form this operation consists in an incision in the median line through the whole thickness of the anterior wall, extending more or less to the fundus, whereby the organ bcconuN already much more mol)ile. Another way is to excise a wedge-siiaj)ed \)iQ('Q of the anterior wall or to make two incisions, diverging fioin below upward, and remove the intermediate tissue piecemeaL Often it is an advantage to begin by removing the cervix. In cases of" retroflexion the posterior wall is attacked in similar ways instead of tile anterior. Some divide the uterus into an anterior and posterior flap, which are amj)utatcd and thus give i)etter access to the fundus. Others divide the whoh; uterus into two halves in the median line, cut- ting first the anterior wall, then, after having anteflexed the uterus. 516 DISEASES OF WOMEN. the fundus, and, finally, the posterior wall. Tumors may also be cut out from the inside of the uterus with long straight or curved knives and scissors, and pulled out with forceps with teeth like N^laton's cyst-forceps (see Ovariotomy and Fig. 296). In all these operations the uterine arteries are first secured, and, if possible, the broad ligaments too, but often this is impossible, and hemostasis is then obtained provisionally by pulling the uterus down all the time, and often by everting the fundus and thus twisting the Fig. 296. Morcellation of Fibroid Tumors of Large Size (P6an). broad ligaments ; besides that the uterine tissue itself does not bleed much. Before cutting off any piece of the uterus a good hold on the remainder must be secured with a bullet- forceps or a four-pronged (Fig. 197, p. 228) or eight-pronged traction-forceps. Another prin- ciple is only to cut what can be seen, and to see or feel all tissue that is being ligated or clanaped, so as to be sure of not including the intestine in the part grasped. With large tumors the principle is to remove as much as possible of the tumors, and deal with the uterus DISEASES OF THE UTERUS. 517 subsequently. In all eases the uterine cavity should be disinfected. While a moderate morcellation is easy to perform and very helpful, it need hardly be said that the last described procedures are dangerous and require great dexterity.^ Limits of Vaginal Hysterectomy. — P^an removes all uterine fibroids by the vaginal method, if the fundus is below or even a little above tiie umbilicus. In most operators' hands it will probably be safer to prefer the abdominal section when the uterus is larger than a normal fetal head at the end of gestation. Vaginal Hysterectomy without Ligature or Pressure-forceps. — The uterus and the appendages may be removed without securing a single vessel. This is based on the anatomical fact that the trunks of the large arteries, the uterine and the ovarian, are situated in the broad ligaments at some distance from the uterus, tubes, and ovaries, and send only small branches into these organs. In regard to the uterus, the writer has found and shown before medical societies that each branch of the uterine artery has a very fine lumen and a very thick muscular coat, so that the very severance of the little vessels makes its thick muscular wall contract. If, however, a few arteries spurt, they are seized separately and tied. The advantage claimed for this method is that we avoid compressing nerves, which we do in using ligatures or forceps. The operation is feasible, but less safe than the other methods.^ The writer has successfully removed the uterus in this way in cases in which the appendages had been removed before, but a case ending fatally from hemorrhage has been mentioned in a society meeting in this city. The opening left at the to]) of the vagina by hysterectomy closes by granulation in the course of three weeks. The patient may be allowed to get uji at the end of the second week. As soon as the wound canal is shnt off from the abdominal cavity by granulation, vaginal antiseptic injections may be used. There is often formed some proud iiesh which does not heal, and may keep up a discharge indefinitely. Thos(! granuhitions ought to be scraped off witli a sharp curette and the wound touched with lunar caustic. Abdominal Hysterectomy is done either by sujiravaginal ampnta- iion or by total e.vtirpation of the uterus. Su])ravaginal Amputation of the Uterus. — In tiiis operation the cervix or a small part of it is left and forms a stump. There are two chief varieties, with intra-abdoviinal and witii e:ctra-alxlominal treat- ment of the pedicle. ' Details about ninrcollation niav hi- fouiul in an article by Edgar (rarceaii, in Amer. Jour. ObM., March, 1895, vol." xxxi. pp. 305-346. ' It is an old operation, having been performed as early a.s 1^22, revived in our davs by Dr. K. H. Pratt of Chicago, .Jour. Orificinl Surf/., .Jiuie, lS!t4; (ieo. Knpelniann, "History of Vaginal Hysterectomy," Anrr. Jour. (Jbst., Feb., 1895, vol. xxxi. p. 295. 518 DISEASES OF WOMEN. 1. Intra-abdominal, Retro-peritoncdl Treatment of the Pedicle. — Tlie unquestioned victory won in ovariotomy by the intra-peritoneal treatment over its rival the extra-peritoneal constantly has impelled surgeons to apply the same ])rinciple to the amputation of the uterus; but special difficulties are met with in the contractility of the pedicle and the danger of infection taking place through the cervical canal — unfavorable circumstances, which, however, have been obviated in different ways. Modus Operandi. — An incision is made through the abdominal wall, extending from the sym})hysis pubis to the umbilicus or still farther. In so doing, most operators go to theleftof the umbilicus. Acorkscrew is bored into the uterus, by which it is more easily tilted out through the wound and manipulated later. If the tumor is not very large, the fundus may be seized with a strong volsella instead of using a corkscrew. After turning out the uterus, the edges of the abdominal incision above it are held together and covered with a flat sponge or pad. With large tumors extending far beyond the umbilicus the writer has found it advantageous to insert four sutures through the whole thickness of the abdominal wall before turning out the uterus, and tie them after it is done and before commencing the removal of the uterus. The infundibulo-pelvic ligament, including the ovarian vessels, is tied, a long pressure-forceps (Fig. 293) placed inside of the ligature, nearer the uterus, and the intervening tissue cut. In placing this ligature it is well to carry the needle around the vessels at a little distance from the free border of the ligament, by which slipping of the ligature is prevented. Next, the round ligament with the funicular artery is ligated, a pressure-forceps placed on it nearer the uterus, and the first incision continued between the forceps and the ligature. From the point where this incision ends, just below the round ligament, a superficial transverse incision is made a finger-breadth above the bottom of the vesico-uterine pouch through the peritoneum to the corresponding point on the otlier side, and the bladder separated from the supravaginal cervix. A similar incision behind, in Douglas's pouch, separates the rectum from the uterus. The uterus is pulled well over to the opposite side by an assistant, and the operator goes with thumb and index-finger down between the two layers of the incised broad ligament until he can see or feel the uterine artery at the upper end of the cervix, where it ascends alongside of the edge of the body of the uterus. Here it is tied and cut after a pressure-forceps has been placed above the line of incision. Xext, the cervix is cut across,' and when the last fibres are cut or torn, the uterus simultaneously being ])ulled well up and rolled ov^er to the other side, the second uterine artery comes into ' H. A. Kellv uses a special spud for this purpose {Bulletin of Johns Hopkins Hos- pital, Feb.-Mar., 1896j. DISEASES OF THE UTERUS. 519 view. It is tied and cut about an inch above the cervical stump, so as to be sure not to include the ureter, which lies below and outward. Next, the second round ligament is reached from below, tied and cut, and finally tlie ovarian vessels. This leaves the uterus with appendages as one piece, to which on the first side are attached three pairs of forceps, which prevent recurrent hemorrhage. Next, the cervical stump is hollowed out a little and its edges sutured together. The anterior peritoneal flap is drawn over the wound and stitched to the posterior flap with a running suture. Instead of ligating the infundibulo-pelvic and round ligaments, they may be caught with pressure-forceps, and the single arteries picked out on the cut sur- face and tied. This may also be done as a particular precaution if the ligaments are ligated. Catgut may be used for all sutures and ligatures. The latter may \)o carried with the Schroeder needle (Fig. 269, p. 462). Finally, the abdominal wound is closed and dressed (see Ovariotomy).' If the myoma extends into the cervix, this may be elongated by constant traction made upon the pedicle by the assistant who is holding the tumor, so that the uterus may be amputated at a lower level, leaving a cupped surface. Separate fibrous nodules may bo enucleated from the stump. 2. Extra-abdominal Treatment of the Ped'u-Ie. — a. ITef/ar's Jllethod. — When the uterus is turned out an elastic ligature is thrown around the cervix, including the broad h'gamonts. Only in exceptional cases, if tiie tension is too gn.'at or the mass too vohuninons, are the liga- ments tied first and cut betw(;en two rows of ligatures. An elastic ligature — a piece of ruljber tubing as thick as the little finger — is turned twice around the cervix, drawn very tight, and crossed once. Then tiie ends are seized in front of tiie crossing between the blades of a pressure-tbrceps, and tied togetlier with a silk ligature behiud the forceps. When this is tied, the ends of the elastic ligatures are j)ulled out a little more, aud a second silk ligature is placed at some little dis- tance i^ehind the first, aud all ends of rubber and silk ligatures are cut short. Another way of securing the elastic ligature is to have an assistant lay the silk ligature on the top of the first half hitch of the knot at right angles to the clastic ligature; next, to tie this with a second hitch ; and, finally, to tie the silk ligature across this second crossing of the elastic ligature. ' Tliis method lias hoeii fvolvcd by Anicriran surpeons, and lias liv Sotrond heon called the Ainerirnn virllioil in contradistinction from the vajiiiial claiii]) iii(tho<l, which is the invention of IVan. The chief points in the Aiiieri<'an operation are the retroperitoneal method of trealinf? the stump (T. A. Emmet, IHSl), the separate ligation of vessels instead of mas^s liualiires ( L. A. Stimson, A'. )'. MkI. Jmir., Mar. 1», 1889, vol. xlix. p. '277), and the side-to-side incision ( \V. K. I'ryor, Mrd. Xrws, Dec. 1, 1894, and TntriK. .V. )'. OhM. S„r., Dec, 1891j. 620 DISEASES OF WOMEN. Next, the uterus is cut off oue and a half to two inches above the elastic ligature, and the peritoneal covering of the stump stitched with a fine curved needle and a continuous catgut suture to the peri- toneum near the lower end of the abdominal incision, under the liga- ture, so as to close the peritoneal cavity. The remaining peritoneal edges are stitched together, and the abdominal wound closed as in other laparotomies, leaving a circular furrow formed of the receding muscular, fascial, adipose, and cutaneous layers of the abdominal wall. The stump of the uterus is transfixed with a pair of steel pins crossing one another at right angles above the ligature. Small caps are pushed over the points iu order to protect the skin. The cut surface and the cervical canal are seared with Paquelin's cautery, and covered, as well as the surrounding furrow, with a mixture of 3 parts of tannin with 1 part of salicylic acid. Finally, the whole is dressed as after a common laparotomy, and the dressing need not be changed for eight or ten days, when the sutures are removed. It is not rare that a bloody discharge from the vagina appears three or four days after the operation. It is without importance. The stump falls off after fifteen to twenty days, leaving a deep funnel-shaped depression, the necrosis extending beyond the elastic ligature. This funnel is dressed with iodoform gauze, which is changed daily until the surface is healed. In leaving the above-described furrow free between the pedicle and the abdominal wall, except the peritoneum, a great source of infection and death has been eliminated, but, on the other hand, a weak point is left in the abdominal wall, and it is necessary for the patient to wear an abdominal belt. If the ovaries are left behind, it happens occasionally that the men- strual flow continues through the pedicle. This method is not applicable to tumors that have not risen up from the pelvic into the abdominal cr.vity ; it entails a tedious conva- lescence ; and it exposes the patient to vcntrnl hernia ; but it is expe- ditious and convenient in dealing with very large tumors. b. Senn's Method. — Extraperitoneal hysterectomy has been much improved by Dr. 8enn of Chicago.^ He does away with the elastic ligature, ligates the uterine arteries, sutures tlis cut surface, and ob- tains healing by first intention. A circular incision is made through the peritoneum, at a point corresponding to that at which the broad ligaments have been divided. The peritoneum is then with the fingers and blunt instruments peeled from the pedicle, which is then (;ut transversely. The uterine arteries are tied immediately after they are divided, and parenchymatous oozing is arrested by ^ Nicholas Senn, Pathology and Surgical Treatment of Tumors, Phila., 1895, pp. 509-511. DISEASES OF THE UTERUS. 521 suturing the stump with several rows of catgut sutures. A small strip of mucous membrane is then excised, after which the cut sur- faces are brought together with several rows of catgut sutures. The stump is stretched to the ^parietal peritoneum, as in Hegar's opera- tion. The pedicle is accessible at all times in case of hemorrhage. The space around the sutured pedicle is packed with iodoform gauze. Secondary sutures are in place, and provisionally tied in a Fig. 297. Extraperitoneal Abdominal Hysterectomy without the use of the elastic constrictor or the wire loop: operation completed (Senn). loop over the packing. On the second day the gauze is removed and the sutures tied ( Fig. 297). While this method is an advance from Hegar's, it is inferior to the intra-alxlominal methcxl as (h'seril)ed above, whicli gives rise to no hemorrhage, is simph', expeditious, and finished at once, and leaves the alxlominal wall free from any unnatural attachment. Total Ah(lomh\(il Krflrpdfinn of the P/o-z/.s. — When th(> body of the uterus with its appendages has been removed as described under Su|)ravaginal ATn])ntation it is not difficult, if so desired, to remove the stump of the cervix. It is seized with traction-forceps and Revered all around partly with closed, partly with cutting scissors. 522 DISEASES OF WOMEN. Even when all throe chief arteries of the uterus are tied on both sides there may be, and commonly is, severe hemorrhage from one or more arteries in removing the cervix. This is due to the fact that the internal iliac often continues below the departure of the uterine artery, and gives ott* the vaginal arteries, either as one or separately as two or three branches (Fig. 37, p. 45). The anterior and superior azygos artery and one or more of the lateral vaginal branches normally anastomose with the circular artery of the uterus, and the origins of the vaginal arteries vary much (p. 45). It happens some- times that the operator, without knowing, cuts into the vaginal vault instead of the cervix. The opening in the vagina may either be left open for drainage or closed. Special Difficulties met with in Abdomined Ili/sterectomy. — The bladder may be spread out and adhere to the front of the tumor. This condition may sometimes be diagnosticated before the opera- tion by means of a male urethral sound. If so, the incision through the abdominal wall should be made above the upper limit of the bladder, the contour of the organ made out l)y the sound, an incision made corresponding to it, and the bladder dissected oif from the tumor, using as much as possible blunt instruments and the fingers. If during the operation the operator is in doubt about the upper limit of the bladder, the uncertainty may be dispelled by directing an assistant to introduce a catheter or a uterine sound into that viscus through the urethra. If the bladder has been wounded, the wound is closed separately wdth a catgut tier-suture (p. 237). The mucous membrane is first closed by one row of sutures, and the remaining tissue is brought together by one or two rows. For the peritoneum it is well to use Lembert's intestinal suture. A catheter should be left permanently in the bladder or the urine drawn frequently. If there is an open uracJnis, it may be avoided by making the incision through the abdominal wall at the side of it. If it has been wounded, the wound may be closed by applying a double tier suture. The writer once, in performing supravaginal amputation for uter- ine fibromyoma on a woman forty-five years old, found the whole fetal bladder preserved, as shown in Fig. 298.^ ^ Specimen from my operation on Miss S. at vSt. Mark's Hospital on Feb. 13, 1899. The bladder presented itself in tlie line of incision after division of the aponeuroser. of the abdominal muscles as a triansjular body, being a. full-width continuation of the lower part of the bladder and ending in a point at the umbilicus. It lay between the transversalis fascia and tlie peritoneum, surrounded by somewhat tliickoned connective tissue, from wliicli it was separated bluntly. The top was tied and cut loose from the umbilicus, and tlie wliole organ dropped into the pelvis. On either side the In'pogastric artery was seen as a hard, solid white cord, one-eighth of an inch in diameter, outside of which the separation was made. The patient succumbed to nephritis ten days after the operation. DISEASES OF THE UTERUS. 523 On the side of the cervix great care should be taken not to include the ureter in a ligature. The omentum is often attached to the tumor. If the adhesion is slight, the separation is best made by brushing the omentum away from the tumor with a dry sponge. If it is tough, it must be cut between one or more sets of double ligatures. Sometimes the intestine is found intimately adherent to the tumor. If it cannot be peeled off, an incision is made on the tumor, through Fig. 298. Kt'tal Ijladdor in adult woiiiuu: (i, bladder; hb, hypogastric artcrios as solid Lurds; ureters; '/, urethra; r, vHK'inn. the jH'ritoneum around the a<lh('sion, and the jK'ritoneum dissected off from the tumor and left in (ionncction with the intestine. Next, the raw surfa(!e is fielded together by means of one or more catgut sutures (Fig. 'I'M)). In order to overcome the diniculties presented bv the mere weight of large soli<l abdominal tumors of any kind, and by tlie assistant who lifts it being in the way of the operator, Reverdin has invented a 524 DISEASES OF WOMEN. particular lifting apparatus. A pulley is fastened to a beam in the ceiling of the operating-room above the table. Over it moves a thick cord, to the lower end of which is attached a metal chain dividing into two smaller chains, each ending in a hook. These hooks are inserted into the rings of a strong volsella, with which the tumor is seized. An assistant, standing at a distance, out of the way of the operator, raises the tumor on command by pulling on the cord. To the chain is fastened a ring or hook, through which the free end of the cord is draw-n, so that the assistant is enabled also to pull the tumor to the side. Fig. 299. Method of Closing Peritoneal Flap left on intestine, after separating it from uterine fibroid (Schroeder) : I, intestine ; P, peritoneal coat of fibroid ; S, catgut suture. Comparison between the Vaginal and the Abdominal Section. — When the vaginal method is feasible it should be preferred. Many patients dislike to have a large cicatrix on their abdomen on account of its unsightliness ; in which respect, however, the operator can do much by skill and patience in uniting the wound after laparotomy. If we use tier sutures, most of them can be placed subcutaneously. Only thin silk or silkworm-gut sutures arc tlien required on the skin. They should not extend far from the edges of the incision. If aseptic when inserted and removed in time, they will not cause suppuration. Finally, the cutaneous sutures may be avoided altogether by uniting the edges by the subcuticular suture (see Ovariotomy). Another and more serious objection to the cicatrice is that it may yield in the cour.se of time and give rise to a ventral hernia. This danger is much smaller in the vaginal section on account of the small- ness of the wound and the thickne.'^s of the cicatricial plug in case it is allowed to heal by granulation. There is much less shock in the vaginal operation, which is chiefly due to the fact that the intestine is not handled. The patient need not stay so long in bed as after lap- arotomy, and the after-treatment is simpler. On the other hand, the vaginal method is more difficult on DISEASES OF THE UTERUS. 525 account of the smaller dimensions of the field. Adhesions are more difficult to separate or cannot be reached at all. Hemorrhage is more difficult to check. The bladder and the intestine are more exposed to injury, and if such an accident occurs, it is more dif- ficult or impossible to repair the injury. The pelvis cannot be ex- plored so easily for concomitant disease, and the abdomen not at all. There is usually somewhat higher temperature the first few days after the vaginal operation, and in most of the methods there is more or less dead tissue to be thrown off, during which time it gives rise to an offensive odor. Comparison between Total Extirpation and Supravaginal Amputa- tion of the Uterus. — For the treatment of fibroids, in which the cervix, or at least the lowest part of it, is healthy supravaginal amputation is preferable to the total extirpation. There is hardly any hemorrhage, while in the total extirpation, at least when the whole operation is performed from above, there is oflc i toward the end of the operation a troublesome hemorrhage from an artery hard to find and to secure at the bottom of the deep wound. The supravaginal amputation is easier and can be performed in le.-s time. The stumps of the broad ligaments and the roof of the vagina hold one another, so that there is no danger of prolapse of the vagina nor any danger of vaginal hernia (p. 354), which occasionally has been observed after total extirpation. The vagina retains its depth, while sometimes it is shortened in the rival operation. The mortality is little more than one-half of that of total extirpation.' There are numerous modifications of these myoma-operations, upon which the scope of this work does not allow us to enter. Abdominal Enucleation or Jfi/omcctomi/. — A fibroid may l)e enu- cleated ; that is to say, separated from the surrounding tissue and removed from the substiuice of the uterus, from the broad ligaments, or from the pelvic floor. A. Ewu'tvation from the Uterine Wall. — When the uterus is not studded with fibroids or their size is too large, and if there is reason to iielieve they are intrair.ural, enucleation of the tumors is to be preferred to hysterectomy, as thereby the genital organs ar<' preserved in their integrity. In order tf) avoid hemorrhage an elastic con- stri(;tor may 1)0 aj)j)li(!d around the cervix and the broad ligaments. An incision is carried right through the muscular tissue covering the tumor. This is shelled out of its eapsule, and the cavity closed with rniining tier-sutures of catgut. If there are several myomas, it may be necessary to make nHiltij)le incisions. That the tumors are not submucous may i)e inferred from the fact that they have only ' Olshansen lia.s coUectt'd the following; statistics: supravaginal aiiipiitatiou, 806 cases, 45 deaths 5.6 j)er cent. ; total extirpation, 520 cases, 50 deaths [KG per cent., Veil's Handbuch dcr dynakolorjie, vol. ii. p. 713, Wiesbaden, IfS'JT. 526 DISEASES OF WOMEN. caused some increase in the menstrual flow, no serious liemorrhage nor intermenstrual loss of blood. If the uterine cavity is opened, the operation may still be continued ; but in that case the endo- metrium siiould be brought together by a separate suture. If it is impossible to arrest hemorrhage in any other way, supravaginal amputation should be resorted to. In ease it is found impossible to unite the walls of the cavity left after the enucleation of a libroid by suture, Alexander's method might offer a means of ending the operation before recourse is had to supra- vaginal amputation of tlie uterus. After having temporarily clamped bleeding vessels, he packs the cavity with iodoform gauze and closes the edges of the wound in the uterus by suture, leaving each end of the gauze hanging out at the ends of the incision. Kext, he closes the abdominal wound and draws the gauze out through the two ends of the wound. This gauze serves the double purpose of a plug and a drain. It is gradually withdrawn, the cavity closes, and, finally, the uterus drops down to its normal place.' B. Enucleation from the Broad Ligaments. — If possible, it is a j^re- caution ag-ainst bleediuo- to tie the ovarian and uterine arteries. But even without this a transverse incision is made through the peritoneum over the whole tumor. The peritoneum is stripped back with the finger, and a volsella inserted into the tumor, which is pulled up- ward. As a rule, the tumor is enucleated without a pedicle ; in other cases the tube or the substance of the uterus forms one, which is tied and cut. The enucleation should be performed from above downward and from the wall of the pelvis toward the uterus, so as to avoid the ureter and have the uterine artery in the pedicle if there is one. A large cavity is left, that may be dealt with in diflFereut ways. 1. A. Martin's method is to perforate the bottom so as to enter the vagina with a forceps which is pushed through to the vulva. Here a soft-rubber T-shaped drainage-tube is seized, and pulled up till the transverse bar lies in the bed of the tumor. Then the peritoneum is stitched together. 2. Fritsch's method is to cut off redundant tissue, stitch the edge of the pouch to tlie edges of the abdominal wound, and fill the pouch with iodoform gauze disposed like a fan, Avhich serves both to check hemorrhage and to secure drainage. Another way of packing the iodoform gauze is that of Mikulicz : a large piece of gauze with a strong silk thread attached to the middle is introduced into the cavity to be compressed, and is filled with strips of gauze like a bag. After a day the interior strips are withdrawn, and finally the outer piece is removed by pulling on the silk thread. If it is not possible to stitch the sac to the abdominal wall, it is ^William Alexander, Practical Gynecolorjy, Edinburgh, 1899, p. 112. DISEASES OF THE UTERUS 527 packed with iodoform gauze, tlie peritoneum closed over it with a tobacco-pouch suture, an incision made in the vagina, and the end of the gauze, which has been marked beforehand bv attaching a silk thread to it, pulled a little down into the vagina. In both cases the vagina is solidly tamponed with iodoform gauze. 3. A third method (Hofnieier's) is to stop hemorrhage by stitching the bleeding places with a continuous catgut suture, and let the walls of the wound fall together. Sometimes it suffices to touch the bleeding spots with Monsel's solution or the thermocautery. It is also advisable to throw an elastic ligature around the cervix as soon as feasible, or around the lower part of the tumor, so that a part of it may be cut off, which facilitates the removal of the remain- der (so-called morcellation). C. Enucleation from the pelvic floor, under the broad ligament, is still more difficult and dangerous. Ifis carried out according to the same principles as for intraligamentous tumors. Small tumors springing from the cervix or lower uterine segment can sometimes l)e enucleated from the vagina, either by posterior col- potomy,as in the first step of vaginal hysterectomy (p. 510), or by ante- rior colpotomy,as described in treatingof vaginal hysteropexy (p. 473). Complication with Pre(/)}((uci/. — Fortunately, most women with fibroids are sterile, and if they conceive, their })regnancy quite fre- quently ends in abortion or in premature labor. Labor at term may be easy, but oftener the fibroid j)roves a dangerous com])lieation. If we are consulted as to the advisability for a woman afflicted with a fibroid of the uterus to contract marriage, it is, as a rule, best to dis- suade her from it. Pregnancy having occurred, it is in harmony with nature's own method to induce abortion or j)rematurc labor, if the tumor is situated in such a place or has such ])roportions that great trouble may be anticipated by allowing gravidity to go on to full term. To perform operations during ])regnancy will be likely to lead to abortion. Unless there be urgent symj)toms, such as hemorrhage or pressure, it is better to delay ()|)erative interference till labor sets in. A pedunculated subserous tumor may sometimes be ])us]ied up out of the way of the cjiild. A cervical tiunor may be enucleated, and on account of the succulence of the womb and the uterine contractions ]>resent, the enucleation is both easier and safer than under ordinary circumstances. But if the tumor extends high uj), it may be neces- sarv to perform (VsarcMii section, supravaginal amputation, or total extirpation, or to .sicrifice the cliild. If the child has been horn, it is better to j)ostj>one the consideration of o))eration, so much moi"<' so as we have seen that the tumor may (lisa|»pear during involution. Sloiif/hitif/. — l''or some gynecologists the appearance of sloughing in a sessile filtroid is an indication for hvstcrectomv. 'I'akini:- into 528 DISEASES OF WOMEN. consideration the unfavorable condition in which that grave operation would have to bo performed, and the case referred to above (p. 508), I am inclined to think a more palliative treatment is preferable, especially if septicemia has developed. Decubitus Aeutus sive Ncuriticus, Acute Bedsore. — This is a uni- lateral gangrene which sometimes complicates operations in which the nerves of the j)elvis are pinched or otherwise irritated. Segoud has observed its occurrence in nearly 1 per cent, of his vaginal hysterectomies. AVomen who suffer from old perimetric inflamma- tion seem to be predisposed to this occurrence. On one side of the crest of the sacrum and the corresponding part of the nates appears suddenly an erythematous spot with a more or less regular contour, rather sensitive to touch, and accompanied by a pronounced swelling of the derma and subjacent tissues. There is a rise in temperature, and the general condition is bad. In the course of a few hours blebs filled with a reddish fluid are produced on the erythematous area, and in two or three days an eschar is formed as large, at least, as the hollow of the hand and implicating all the soft parts down to the bone. All the patients thus affected have recovered, the eschar being thrown off and the wound filling up slowly.^ 3Iortality. — In deciding the question of the advisability of per- forming cutting operations for tlie removal of fibroids, we should bear in mind that the disease for which they are to be performed rarely leads to death ; that, as a rule, improvement takes place after the menopause ; and that, on the other hand, tlic operation is folloAyed by a large mortality. Until recent years operations were very fatal. - But constant progress is being made, and several opei'ators have of late reported long series of hysterectomies without a death. Early recourse to operation, as well as an improved technique, has had great influence in diminishing the mortality. It would, however, not do for the average operator, and still less for the beginner, to expect results like those of Pean and Tait, who reduced their mor- tality to 1.5 per cent. The mortality among good American opera- tors ranges now between 5 and 6 per cent.^ ^ Paul Segond, Revue de Gynecologie, No. 1, pp. 59-66, Jan.-Feb., 1897. ^ Complete statistical tables are found in "A Review of the Operation of Gastrot- oruy for Myofibroma," by II. R. Bigelow of Washington, D. C, in Ame): Jour. Obst., 1883-84. <leo. W. Johnston of Washington, D. C, has collected a large number of cases of fibromata of the cervix, Amer. Jour. Ohi<t., 1885, vol. xviii. p. 1280. (See also "Analysis of Home Statistics on Supravaginal Hysterectomy," by Marie B. Werner, Annals of Gynemlogi/, Oct., 1892, vol. vi. p. 56.) s Chas. P. Noble, Med. and Surg. Reporter, June 2, 1894, publishes the follo\¥ing table : Kelly 57 cases 2 deaths. Baer 57 " 3 '' Polk 40 " 3 " Noble 14 " 1 " Total 168 cases 9 deaths = 5.36 per cent. DISEASES OF THE UTERUS. 529 Causes of Death. — Death after fibroma-operations is due to shock, hemorrhage, septicemia, nephritis, embolism, intestinal obstruction, ligation of the ureters, or tetanus. Shock plays a very great role in operations that often are very pro- tracted,' and in which the abdominal organs are exposed to much handling. The danger is so much greater, as sometimes, in conse- quence of the presence of the fibroid or its treatment by ergot, the patient has a weak heart. (See p. 244). HemorThar/e is now controlled much better than formerly by means of pressure-forceps and tlie elastic ligature. If the intra-abdominal treatment of the pedicle is used, internal hemorrhage may take place after the operation is finished. This dangerous condition makes itself known by the restlessness of tlie patient, a weak, frequent pulse, pallor, a cold, clammy skin, a swelling of the abdomen, and sometimes a distinct feeling of the warm fluid being poured out into the abdom- inal cavity. Under such circumstances the only means of rescue is speedily to reopen tlie abdomen, clean out the cavity, find the source of hemorrhage, tie the bleeding vessel or put in additional sutures, inject warm saline solution (common salt, a little over ^ per cent., will do) into a vein, into the peritoneal cavity, into the rectum, or under the skin. (See p. 220.) For any of these injections an apjKi- ratus which I descrilxd in 1878, and have used many times with success, will be found convenient. It is essentially a fine Davidson 'iarritrncs' Transfusion nrul Inftision Apparatus : /I, pluntjcr ; /;, bulb ; r, st(ii)C()ck ; /^ flex- ible probo-iKjiiitfd cunula; K, K, valvis. syringe- (I'ig. .'>()()). For the subcutaneous injection a hollow needle is substituted for the blunt flexible camda. JM)r subcutaneous injec- tions, instead of the valve-syringe, the needle may be cotnie(!ted with tlie tubing of a fountain syringe, which needs less attention. Scjificciiiia may be due to the entrance of path(»genic germs (hiring ' I'l'an's operations have oficn taken tliree hours. (lYanet Uniy, " Ilysteroto- niie," Paris, l>^~'.'>.) '^(iarrij^ues, " Aiijiaratus for Transfusion," Atmr. Jmir. 0/>^7., October. l>7s, vol. xi. No. 4, p. 7o4. U 530 DISEASES OF WOMEN. tlie operation, to the use of insufficiently disinfected materials, and to infection from the pedicle, or perhajis even from the intestine.^ The more bacteriology progresses the more difficult it seems to guard against infection. JVcphriiis. — AVe have seen (p. 218) that- anesthetics produce acute nephritis. As a rule, this is only a transient phenomenon that dis- ap})ears in a day or two ; but occasionally, especially if the kidneys were affected before the operation, the inflammation may become permanent and cause the ])atient's death. Thrombosis beginning in the pelvic veins may extend to those of the thigh, and from the thrombus a piece may be detached and form an embolus. Infesfina! Obstruction may be brought about by exudation and adhesions. The means to avoid it in supravaginal hysterectomy are to lift the intestines up before dropping the pedicle, to avoid as far as possible leaving raw surfaces in the abdominal cavity, and to move the bowels early. (See Ovariotomy.) If obstruction sets in, it should be combated with large injections of lukewarm salt solu- tion from a fountain syringe. The enema with ox-gall described on p. 178 may also be tried. I^avage of the stomach with a weak solution of salt, sometimes combined with the administration of castor oil, has proved very effective. (See Ovariotomy.) If the obstruction remains, the abdomen must be reopened and the obstacle removed manually. The ligation of one or both ureters leads to acute hydronephrosis and vomiting. If thirty-six hours have elapsed since the operation, there would be little danwr of hemorrhao;e in removino- the lio-atures on the uterine arteries, which are likely to be those that include the ureters. The situation being desperate, it might be worth trying this heroic remedy. Tetanus is an exceedingly rare complication. It has been suc- cessfully treated with tetanus antitoxin. If that fails, an attempt should be made with bromide of potassium, chloral hydrate, and curare. Indications for Operative Interference. — Polypi should always be removed, at least when they become easily accessible. Subperitoneal fibroids with a thin pedicle should be removed if they annoy the |)atient or grow miieli. Fibro-cystic and snj^purating tumors nuist be removed. In all other cases Apostoli's treatment should be employed, and o})erations only resorted to in those in which it fails or when it cannot be obtained. When a fibroid grows in s]>ite of medical and electric treatment, it or the uterus containing it should be removed as soon as possible. In regard to fibro-cysts, it may be safer to desist from a total extir- * Welcli, "Wound Infection," Amer. Jour. Med. ScL, Nov., 1891, p. 443. DISEASES OF THE UTERUS. 531 pation, and only to make a large incision, evacuate the fluid, stitch the sac to the abdominal wound, and pack it with iodoform gauze. It will then shrink, and be filled by granulation. D. Sarcoma. Under the vague name of cancel- are united neoplasms of different anatomical structure, having this in common, that they undermine the constitution and sooner or later, in most cases rapidly, lead to death. To this group belong sarcoma, carcinoma, malignant adenoma, — the last being only the first stage of some cases of carcinoma, — and certain impillomas. Sarcoma. — Pathological Anatomy. — Sarcoma preferably aifects the body of the uterus. In the neck it is very rare. It appeal's in three forms — the circumscribed, the diffuse, and the papillary sarcoma. The circumscribed forms globular tumors like fibroids, and used to be called recurrent fibroid, because it developed again after extirpation, which a genuine fibroid never does. Like a fibroid, it may be sub- mucous, intramural, or subperitoneal, and it may form a polypus. It has very rarely a capsule. Its consistency is generally soft and brain-like, but it may be as dense as a fibroid. It may start from the mucous membrane, the muscular tissue, or the peritoneum. Often it has its origin in a myoma. The diffuse sarcoma starts, as a rule, from the submucous connective ti.ssue, invades the mucous membrane, and may spread more or less deeply into the muscular tissue of the uterus or perforate the whole wall, so as to form a tumor in the abdominal cavity. It is composed of a whitish or grayish extremely vascular mass. Most sarcomas have a fasciculated arrangement, bands of fibrous connective tissue separating groups of cells — a disposition which may even be seen macroscopically by l)reaking hardened s|)ecimens. The less fibrous tissue they contain, and the more the cells ]>rcdominate, the more malignant tluy are. In younger ])ortions of the growth a jelly-like amor{)li()us mass is found between the fibrilla) whicli later disappears. The cells may be spindle-shaped or round. Sometimes also so-called giant-cells with many nuclei are interspersed among the others. The sarcomatous tissue is full of enormously dilated ca])illaries with very thin walls, which exj)lains the hemorrhages that form so prominent a featun; among the symptoms. The diffuse sarcoma, as a rule, contains cpitiielial cells, so that a transition is made to carcinoma. SarcoTuas ar(! Ui)t \mmv to ulcerate so soon as carcinomas. As a rule, the tumor (htcs not l)C(!omc decomposed until parts of it descend into tlu; vagina or are removed artificially. In myxosarcoma, also called colloid cancer, there is a })repondcrance 532 DISEASES OF WOMEN. of tlie intercellular amorphous substance containing mucin, to Nvliich is due its gelatinous consistency. Papillary san'oma starts from the vaginal portion of the uterus. It arises from a hypertrophy of the papillae of the mucous membrane, consists of fusiform or round cells, and has a hydropic intercellular substance. Sarcomas may spread to the neighboring organs — the vagina, the bladder, and the abdominal cavity. They may also give rise to Fig. 301. Cj'Stosarcoma of rterus, seen from behind (hall size) : «, uterus: 5, risrlit Fallopian tube ; c, right (jvary ; </, largest cyst cut open ; e, small solid tumor cut open. metastatic deposits at distant places, such as the vagina, lym])hatic glands, the connective ti.ssue of the pelvis, the peritoneum, the liver, the lungs, the pleura, the vertebne, and the skin. A .sarcoma may become cystic, and is then called cysto-sarcoma} Etiology. — The cause of sarcoma is unknown. It is most common at the climacteric age, between forty and fifty years, but differs from ' I have described and represented in the Nev; York MedicalJoumaJ, Angust, 1882, such a case in which the mucous membrane of the uterus was intact, but a large tumor composed of cy.sts and solid masses had been developed in the abdomen. DISEASES OF THE UTERUS. 533 carcinoma by being found iu persons under twenty yeare of age, so that it may be called the cancer of youth. It may even be congenital. It differs likewise from carcinoma in this respect, that among those affected with it many are sterile, while carcinoma is rarely found in women who have never borne children. It sometimes folloM'S endo- metritis or develops in a fibroid. Symptoms. — In the beginning the symptoms hardly differ from those of fibroid tumors — namely, menorrhagia, metrorrhagia, leucorrhea, hydrorrhea, and pain. The uterus may be enlarged and nodular, and may become inverted. But the growth is a rapid one. There is soon established a continuous sero-sanguinolent discharge with offensive odor. The patient becomes emaciated, exsanguinated, and weak, and has an ashy color — a complex of symptoms called cachexia. The cervix often becomes dilated. Pieces of a soft brain-like mass may be expelled from the interior of the Avomb. The pain may be due to pressure or to the nature of the disease. Sometimes it is expulsive in character. The finger introduced after dilatation of the cervix feels the soft mass in the wall of the uterus. Diagnosis. — The diagnosis of sarcoma is by no means always an easy matter. An intramural sarcoma offers the same symptoms as a fibroid similarly situated. The sarcomatous degeneration of the mucous membrane is somewhat more characteristic by the rapid dis- integration that takes ])lace and the speedy development of cachexia. The appearance of a tumor like a fibroid at the time of the mono- pause, and its growth after the same, and hemorrhage recurring after the menopause, must awaken a suspicion of its sarcomatous nature. A sero-sanguinolent discharge, the softness of the tumor, — which often allows the finger to penetrate it or break pieces off' from it, — a more agonizing pain, and the rapid emaciation and cachexia, are all characteristic of sarcoma. In regard to softness, we must, however, remember that it is likewise found in a gangrenous fibroid. From hyperplcuHtic endometritis it is differentiated by greater tender- ness of the b(xly, by the often open cervical canal, by sometimes forming a polypus that iiangs out through the cervix, by tiic apjiear- ance of cachexia, and l)y the spontaneous expulsion of torn-off pieces of the tumor, which never takes j)lace in endometritis. Particles ob- tained by curetting, on the other liand, are deceptive : a sarcoma may furnish a specimen exclusively composcHl of healthy mucous mem- brane, while in endometritis the curette may bring away granulation tissue that looks entirely like small round-cell sarcoma. The clinical diagnosis is, therefore, more reliable than the microscopical, but one may corroborate the other, and sometimes the j)resenee of large cells separated by intercellular ba<is siiljstance is coifclnsivc;. As long as the epithelial cells of the utricular glands — either origi- nal or of" new formation — arc unchanged, the diagnosis of chronic 534 DISEASES OF WOMEN. endometritis is admissible, whatever the nature of the interstitial tissue be. As soon, on tiie contrary, as the regular arrangement of the epithelial cells is broken up, and they give way to sarcomatous tissue, the diagnosis of sarcoma can be made.' When a whole tumor is removed, its nature may be settled by the microscope; and if it is reproduced in the same place or forms metastases, its sarcomatous nature is proved. In this connection it must, however, be remembered that endon^- tritis may produce new fungoid growths after curetting, and that another myoma may develop in another place after one has been re- moved. The differentiation from carcinoma of the body may be impossible, and, as we have seen above, tlie two are frequently mixed in the diffuse form. The discharge in sarcoma is less fetid ; ulceration does not appear so soon ; extension to the neighborhood is slower, and sarcoma may form a polypus emerging from the os, which carcinoma never does. Prognosis. — The prognosis is bad. The disease ends in death, on an average, in about three years, sometimes as rapidly as four months, and very exceptionally as late as ten years. Treatment. — On account of the immense danger to health and life, the best treatment, wlien once the diagnosis is certain, is to perform the total extirpation of the uterus, either by the vaginal or the ab~ dominal method (pp. 510-517). Morcellation should not be thought of, on account of the danger of infecting the neighboring tissue during the operation. Even if the cervix is healthy the whole organ should be removed. Since the development of sarcoma is slower and does not implicate the surrounding ])arts so soon as carcinoma does, the operation is oftener indicated than in the latter disease, and the prognosis as to complete recovery is considerably better. A polypoid sarcoma may be cut off and the base cauterized. If a radical operation is impossible, a palliative treatment, similar to that for carcinoma, especially curetting followed by cauterization with the thermo- or galvano-cautery or nitric acid, and the application of diluted liquor ferri chloridi (1 to 10 parts of water), should be insti- tuted. The application of calcium carbid may also be tried (see Carcinoma). In handling sarcomas great care should be taken to avoid mechan- ical infection of yet healthy parts. Decidual ^arcoma."^ — Of late several cases have been described of sarcoma of the uterus which appeared shortly after abortion or cliild- 1 L. Pleitzmann, Amer. Jonr. Ohst., 1887, vol. xx. pp. nOfi, 907. ^ Aocordinj? to Pfannenstiel, " drrlduomn maJignum" is not a sarcoma, but an en- dothelioma, starting from the endotlielium of the capillaries of the decidua. DISEASES OF THE UTERUS. 535 birth. The tumors were composed of large decidual cells imbedded in a meshwork of connective tissue, forming pseudo-alveoli and con- taining nuclei and giant-cells. The aifection caused increase in size of the uterus, hemorrhage, putrid discharge, metastatic deposits in the iliac fossae, the lungs, and other organs ; and ended in death in the coui"se of from six to seven months. If the diagnosis is made early enough, complete ablation of the uterus is the only rational treatment, and has been performed success- fully. E. Carcinoma. Carcinoma (Fig. 302) is a neoplasm composed of epithelial cells often grouped in alveoli formed of connective tissue, with a tendency to invade neighboring organs and undermine the constitution. Fig. 302. Cervical Curciiioiim of Uterus cxtciidinj; into IJody :' a, body of uterus ; h, cervix ; r, mbe ; d, ovfiry ; c, liylutid ; /, piece of wood inserted in order to expose tlie ciivity of tlie \itcni^. Pfifhohf/ical A)i(tf(iiiii/. — Carcinoma is most common in the VMgiiial portion of the utrrus. Next in fre(|uency is that of ihc ccivix, while that of" the h(Miy is comparatively rare. Uj)on the whole, th(> ' Specimen from my vaj,'iiiiil iivsterectomy on Mrs. C. C. nital, March 25, ISUl. -, St. Mark's llos- .536 DISEASES OF WOMEN. uterus is very frequently aifected in this way, perhaps oftener than any other organ, the only question being if carcinoma of the breast ocoui's as often or oftener. Carcinoma of flic VaghiaJ Portion begins in that part which is covered with flat vaginal ej)ithelium. It does not, however, start directly from the epithelium, but from new-formed glands, and may dip deep into the muscnlar tissue of the cervix without attacking the cervical mucous membrane or the outer circumference. It may also form a papillary growth which develops in the direction of the vagina, and may become so large as to fill it down to the vaginal entrance. From its shape this form lias derived the name of canli- floiccr crcrcaccnce. A third form is that of a flat ulceration, which has been described under the name of rodent ulcer. Cervical carcinoma begins as nodules in or under the mucous mem- brane of the cervical canal, which coalesce and form an ulcer on the mucous membrane, whence it may spread outward, forming a deep cavity in the cervix without showing at the os or invading the corpus. The carcinomatous degeneration may begin in the glands of the mucous membrane or in the connective tissue. Carcinoma of the Body may be primary or secondary. The primary starts from the epithelium of the surface or from the glands. It appears in a diffuse and a circumscribed form, tlie latter forming a tumor, which may become pedunculated so as to form a polypus. Often the nmcous membrane of the body is aflected at an early date in cases of carcinoma of the cervix. In regard to differences in structure, several varieties of uterine carcinoma are distinguished : 1, epithelioma, where flat or cuboidal epithelial cells are arranged concentrically, so as to form so-called can- cer nest^ or pearls — a form probably only occurring in the cervix ; 2, adenoid carcinoma, composed of columnar epithelial cells, and cha- racterized by the presence of tubular formations, with manifold con- volutions, arranged in groups or alveoli or exhibiting a plexiforra arrangement, the epithelial cells often breaking up into medullary corpuscles; S, medullary carcinoma, \vheve the cellular element pre- dominates, forming a soft mass ; and 4, scirrhous or fibrous caraino- ma, in which there are larger trabecule of fibrous connective tissue, imparting greater hardness to the growth. Of these varieties the medullary is the one that grows fastest and soonest leads to a fatal issue. Carcinoma of the uterus extends to neighboring parts, especially the vagina, the bladder, the pelvic connective tissue, the tubes and ovaries, the peritoneum, the rectum, and very rarely the bones of the pelvis. When ulceration takes place, a vesico-uterine fistula may be formed, or, more rarely, a rectovaginal fistula. The internal iliac, sa- cral and lumbar, or the inguinal glands become infiltrated according DISEASES OF THE UTERUS. 537 to the part of the uterus that is aifected (p. 62). Of the above-named varieties, the epithelioma is least likely to spread to the glands. If the bones are aifected, the growth may enter the hip-joint and dislocate thefemur; the tumor may compress the ureters, causing hydronephrosis. Compression of an artery may be followed by the formation of an arterial thrombus, but thrombi are much more commonly found in tlie veins of the pelvis and the thighs. They may be due to direct pre&sure or be caused by the general marasmus and weak heart- action. Secondary carcinoma of the body may attack the uterus by exten- sion of a primary carcinoma from the bladder, the rectum, the ovary, or the peritoneum of Douglas's pouch. Metastases from uterine carcinoma are rare, but have been found in the liver, the stomach, the lungs, pleurae, kidneys, the peritoneum, the brain, and other parts. Etiology. — Carcinoma of the uterus is a disease of advanced age. Jt is very rarely found below the age of twenty, in which res])ect it diifers from a sarcoma. It is most common during the first five years following the menopause. It is much more frequent in the lower classes than in the higher walks of society, ])robal)ly because poor women, as a rule, have more frequent childbirths, because they are much less cleanly, and because worry and want favor the malig- nant degeneration. It is to some extent hereditary, and is frequently found in families other members f)f which are tuberculous. Perhai)s also syphilis in ancestors, by giving rise to a deterioi-ated constitution, may jwedispose to it. ' Carcinoma of the neck is usually found in women who have borne a large number of children or had difficult labors. Lacerations of the cervix (j). 415), with the concomitant eversion, glandular devel- opment, and erosions, are apt to become the starting-))()int of it. Carcinoma of the body, on the other hand, is comparatively com- mon in nulliparous women. Benign tumors may in the course of time become carcinomatous. Carcinoma of th<; placental site is mon; common than sarcoma (p. 534), and originates from the syncytium of the villi chorii (('(trci- iiotiuf .syncytidlc). The syncytial character is even repnuluccd in metastases.' Carcinoma in general is found twice as often in brunettes as in blondes, but, in the United States, twice as often among whites as among blacks. Carnivorous animals arc more ])rone to cancer than herbivorous, just the reverse being the case concerning tuberculosis. W omen are nujch more the subject of cancer than men. It is more preva- ' Jlirst, Tift-l'xiok <ij (//jxlflrirs. p. 129. 538 DISEASES OF WOMEN. lent in certain localities than in others. Thus Buffalo, N. Y., is near the center of an area with a radius of two hundred miles where the death-rate from cancer is greater than in any other part of the States. Malignant tumors are more frequent in habitations sur- rounded by or near W(jods and in persons who are occupied in woods. Although carcinoma undoubtedly is transmissible from one part of the body to another with the current of the blood and lymph, there is no evidence that it can be inoculated into another individual, and the great rarity of carcinoma of the penis compared with the very common appearance of the disease in the cervix uteri goes far to show that the disease is not transmissible by coition. Still, much evidence is accumulating in favor of cancer being a germ disease. Sanfelice, Roncali, and their pu])ils have proved experimentally that certain blastomycetse are capable of being isolated by culture from certain carcinomas and sarcomas, and of producing in animals into which they arc injected tumors strikingly analogous or identical with those from wliicli the cultures were made, from which artificial tumors the germs can again be isolated and used for farther inoc- ulations.' Statistics in Enghmd and America show that cancer has increased alarmingly of late. According to the returns of the Board of Health, the number of cases in New York State has nearly doubled during the decade 1885-1895. Si/mptoms. — The first symptom that brings the patient to seek advice is loss of blood. Often it is only a slight bleeding following coition. In other cases it is a return of bloody discharge after the menopause. In others, again, the menstrual flow becomes too abundant or pro- tracted, or there is loss of blood in the intermenstrual period. Another early symptom is a common leucorrheal discharge streaked with blood. Sometimes a shooting pain or a dull ache occurs at inter- vals in the sacral or hypogastric region, or the patient may have sciatica. If the carcinoma is developing in the collum, we in most cases find a laceration with eversion. The mucous membrane is swollen, bleeds easily, and contains hard nodules. The cervix is indurated in its totality, and not only at the angle of the tear, where a cicatricial plug (p. 416) is so common an occurrence. At the same time, the tissue is friable, so that a part may be scraped off with the nail. Sometimes the uterus is tender on ])ressure. In carcinoma of the body there are no other early symptoms than hemorrhage and leucorrhea. As the disease progresses these symptoms may become more 1 Koswell Park, " An Inquiry into the Etiology of Cancer," Amer. Jour. Med. Sci., May, 1898. DISEASES OF THE UTERUS. 539 marked and new ones are added. The hemorrhage often becomes profuse. After ulceration has taken place there is at times a profuse watery discharge with a penetrating, most disagreeable odor, and in the interval a fetid muco-purulent discharge. The pain becomes more constant and intense. In carcinoma of the body paroxysms of expulsive pain are caused by detached pieces of the neoplasm which cannot pass out through the closed cervix. Finally, the whole body aches. In other cases the pain may be due to peritonitis or to the direct affection of the nerves in the uterus. The acrid discharge is apt to cause pruritus vulvae and excoriations of the skin on the inside of the thighs. In some cases different forms of dysuria are present. Cystitis, causing frequent and painful micturition, is common. If one of the ureters is compressetl or invaded by the new growth, hydrone- phrosis is developed on the corresponding side. The amount of urine that is excreted is diminished. The patient complains of pain in the lumbar region, nausea, and headache. If both ureters become obstructed, complete anuria sets in, followed by uremic convulsions and death. In other cases the uremic symptoms become less toward the end, the obstruction being removed by the extension of the ulcer- ation. In regard to the alimentary canal, the patient frequently complains of a bad taste, thirst, loss of appetite, eructations, nausea, vomiting, and constipation. The hemorrhoidal veins surrounding the anus often swell. She loses flesh and strength, and her skin has a peculiar ashy yellowish hue. If venous thrombi form in the ])elvis and thigh, the corresponding extremity becomes swollen and unwieldy. Sometimes the abdomen is swollen, some ascitic fluid may collect, and the cutaneous veins in the abdominal wall become distended. Peritonitis is of frequent occurrence. Inflammation of the lungs, pleurie, and kidneys is less frequent. Sonietimes dysentery sets in. A detached embohis may be driven into the pulmonary artery and put a sudden sto}) to the suflerings of the ])atient. Septicemia is rare, tlie inflammatory exudations serving as a barrier against the entrance of the products of decay into the circulation. The glands in the groins and in tiie depth of the pelvis are felt to be enlarged. By vaginal examination we find the uterus to be immovable. "^I he vaginal vault is as hard as a board. From the cervix we may find hanging a soft j)olv|)oid tumor, which may fill the whole vagina. It is friable and bleeds ea-ily. Or the finger enters a crater-shaj)ed ulee'nition surrounded hy hard walls. Often the infiltration with car- cinomatous tissue can l)e felt as hard nodules in the broad ligaments or as a hard string following the course of the uterine vessels out to the pelvic wall. 540 DISEASES OF WOMEN. Diagnosk\ — A sponge left in the vaj^ina and forgotten lias given rise to such hemorrhage and offensive discharge that it has been taken for a cancerous growth. An examination with the finger and the eye and the removal of the foreign body will soon settle that error. The distinction from erosions may be difficult. A papillarj^ ulcer surrounded by follicles is likely to be benign. On the other hand, we find in carcinoma of the cervix a sharp line of demarkation be- tween the diseased and tiie healthy tissue: the former is elevated, has a yellowish tint, and contains glistening yellowish-white nodules. The carcinomatous tissue is more friable than the healthy or simply inflamed, so that a ])iece may be broken off with the nail of the exam- ining finger. The result of treatment as a diagnostic measure is valu- able : erosions heal in a short time if they are treated with sulphate of copper or some other astringent (p. 434), whereas carcinoma spreads in spite of the treatment. Microscopical examination maybe entirely negative, but in many cases it gives positive information in regard to the malignancy of the tissue. For this purpose a wedge-shaped piece must be cut out of the cervix, choosing the most affected spot and going deep enough to include in the excision part of the muscular tissue. The wound is united by a suture. The operation is so little painful that general anesthesia is superfluous. A strong solution of cocaine may, however, be applied to advantage. The excised part should be hardened, cut, and stained. The diagnosis of carcinoma is only warranted if atypical epithelial pegs dip into the muscular tissue. A carcinomatous ulceration must be, and in most cases is easily, distinguished from the other kinds of ulcers found on the cervix (p. 444). Chancroid is an acute affection characterized by sharp edges, a yel- low bottom, a red halo, and an abundant secretion of pus of a different odor. Chancre may give rise to doubt, but the history, the presence of other syphilitic symptoms, the result of an antisyphilitic treatment, and microscopiciil examination furnish abundant means of dispel- ling it. TubercuIoHS ulcers are surrounded by tuberculous nodules ; are, as a rule, combined with tuberculosis of other parts, especially the lungs ; and sliow the characteristic bacillus. The simple friclion ulcer found where the cervix protrudes in front of the vulva is surrounded by bluish tissue, and heals easily under proper care. The lymphatic glands are not affected. Corroding nicer ' has not such hard surroundings, and can be diag- ^ Corrodinrj ulcer is the term used bv Dr. AVilliams for tlie one lie ascribes to senile gangrene caused by calcification of the internal iliac arteries, while rochnt nicer is the old classical name that may yet be retained for very flat ulcerations of the vaginal portion, which extend very slowly to the sides, and very late dip into the depth of the cervix, but are microscopically proved to be carcinomatous. DISEASES OF THE UTERUS. 541 nosticated by means of the microscope, which shows absence of epithelial proliferation. Papillary hypertrophy may give rise to small benign growths, bnt they have a narrow base ; w^ien seated on a broad base a papillary growth is carcinomatous. Carcinoma of the body has to be differentiated from hyperplastic endometritis, fibroma, and products of conception. In regard to hyper- plastic endometritis tlie reader is referred to what has been said above (p. 431). Here we will only add a few words about the microscopical examination. The diagnosis of scrapings removed by the curette as being carcinomatous is only warranted if we meet with encephaloid masses which show, not a glandular structure, but atypic epithelial pegs. Fungous endometritis is characterized by the presence of a varying number of tubular glands, the epithelium of which is un- broken. The interglandular tissue may be crowded with lymph- corpuscles, or it may be myxomatous or fibrous in character.^ A fibroid follows a benign course. It develops very slowly, no particles are expelled, there is no l)ad odor, the uterus is freely mov- able, the patient has no fever, and her constitution does not suffer except from loss of blood. She may be pale, but she has not the yellowish color of carcinoma. It is true, a fibroid may slough, and then there may be higli temperature and fetid discharge, but this is a condition tiuit comes on suddenly, and ends in a short time in death or recovery. Pieces of secundine.s may be retained in the uterus for years and cause considerable hemorrhage, pain, and leucorrhea. When they are removed with the curette the microscope clears the diagnosis, and the patient recovers. The diagnosis from .sarcoma can only be made by a microscojiical examination of expelled, scraped-off, or excised parts, carcinoma being comjwscd of rpithclial angular cells, sarcoma of round or spindle-shaped. The diagnosis is in so far of imjiortance, as the prospects for success in a radical operation are greater in sarcoma than in carcinoma. H' the early recognition of carcinoma may Ix; difficult, in its ad- vancc<l stage the disease presents so uniform a picture that it is easilv recognized, tlie most striking featiu'es being the hemorrhage, the offensive watery discharge, the immobility of the uterus, the implica- tion of neighboring organs, the crater-like ulcer, the large, friable, soft mass springing from it, tlu; pains, and the cachectic condition. The ascitic fluid accomj)anyiiig ean-inoma of the body and obtained by aspiration contains sometimes large round or peai'-shajx'd endo- thelial c(!lls with large nuclei, either isolated or in groups. This sign is of some positive value, but not of negative — /. r. if' these malig- * Louis Heit/.Dianii, Ainrr. ,Jonr. ObM., St'j)t<.'ml)i'r, 1SS7, p. \)\\). 542 DISEASES OF WOMEN. nant cells and cell-groups are found, it is very likely that the disease is malignant (carcinoma, sarcoma, or papilloma), but their absence does not prove anything.^ Prognosis. — The disease is fatal. Even the most radical treatment effects only quite exceptionally a permanent cure, and it is even doubtful if, upon the whole, it prolongs life. Under palliative treat- ment patients affected with carcinoma of the cervix may live three or four years. When the disease is in the corpus they live rarely more than one or two. Treatment. — Prophyla.ris. — Cervix lacerations, if they give rise to eversion and consequent irritation of the mucous membrane, should be operated on (pp. 418, 419), and endometritis treated as stated above (pp. 433, 434). Coe^ recommends the excision of the cervix in cases of extensive erosion with general induration, whether cancer has actually developed or not. He cuts out a cone, the apex of which may be as high as the OS internum, the raucous membrane of the entire canal being removed with the cone, but leaves the vaginal mucous membrane. He then introduces a plug of glass or iodoform gauze, and closes the cervix with deep silver-wire sutures. Palliative Treatment. — By far the greater number of patients do not come under observation before the disease has spread so much that a radical treatment, aiming at the complete removal of the affected part, cannot be instituted wath any hope of benefiting the patient. But very much may be done to relieve her, prolong her life, and make her a less objectionable companion for others. The chief indications are to relieve pain, combat hemorrhage and bad odor, and keep up the patient's strength. The disease being fatal, and having only a duration of a few years, we need not be afraid of making opium-eaters of our patients (p. 244). There are no other drugs that will relieve the pain of cancer as opiates do, and the patient should simply have as much of them as is needed to make her comfortable. In cancer of the cervix small doses will suffice for a long time, and need only be increased very gradually. In the beginning four drops of Magendie's solu- tion, two or three times a day, are enough, and I have not found it necessary to go beyond ten or twelve (Iroj)s three or four times a day in the later stages. The hypodermic injection is most efficaci- ous, but for obvious reasons most patients take their morphine by the mouth. In cancer of the body larger doses are required to dull the pain. Moderate hemorrhage may be kept in check by means of injections with chloride of iron (p. 176). In more profuse hemorrhage, or if ' For details see Garrigues' Diagnosis of Ovarian Cyst, pp. 94-97. 2 H. C. Coe, Med. Neivs, Feb. 16, 1889. DISEASES OF THE UTERUS. 543 the seat is in the body, curetting (p. 180) is of great value. In removing large sprouting masses from the cervix I have found Thomas's spoon-saw (p. 505) a very useful instrument. The patient is placed in the dorsal or left-side p()sitit)n, Garrigues' weight-speculum or a Sims speculum is introduced, the tumor is seized with a volsella, and as much of the friable tissue as possible is removed with the spoon-saw, followed by Simon's sharp spoon. Jagged edges may be cut off with curved scissors. Most operators use the thermo- or gal- vano-cautery as supplemental to curetting in order to arrest hemor- rhage and destroy infiltrated tissue. Others object to the cautery, because it destroys the tissue that is not yet affected, and thus hastens the pr(x;ess of destruction. Whether the cautery be used or not, the cervix is packed with pledgets wrung out of a solution of chloride of iron (p. 184), and the vagina with an antiseptic plug (p. 184). After having removed this tam])on the next day, some ap]dy pled- gets wrung out of a solution of chloride of zinc (.^v to distilled water ^j,or, if there is a wall more than a quarter of an inch thick around the cancerous tissue, even equal ])arts). The vagina is protected by a tampon of cotton balls wrung out of a solution of bicarbonate of soda (1 part to 2 of water), which is left in for two or three days. If the zinc pledgets do not come off easily, they are left for a day or two longer. This treatment produces a thick slough, leaving a vel- vety surface, and is followed by considerable contraction. It may even effect a permanent cure, but is not quite safe, since the action of the caustic may involve healthy tissue or the cancerous degeneration go deeper than anticipated. During the separation of the slough and cicatrization disinfectant injections are used. Some substitute excision with knife and scissors for curetting as the first step in the chloride-of-zin<; treatment, cutting out a cone from the vaginal junction to the internal os. Nobody should undertake curetting for a large cancerous mass without being ])rej)ared to ligate the uterine artery from the vagina (p. 188), or even to extirpate the uterus if necessary.^ It is also recommended to scrape off all diseased ti.ssue and dress the wound with a sjiturated solution of soda. Hemostatic drugs ni\> not of much avail. Gossypium (p. 214), however, is useful as an adjuvant. Injections with crcolin (j). 177) are very valuable, both as a hemo- static aud an autiseptie. Tiie odor of the drug itself is by no means disagreeable. Still nioi-<! astringent is li(ju. ferr. chloridi (p. 17(J). ' T (lid so in a rase in wliich I liad refused to jx'rfnrin the radical operation on account of infiltration of the liroad lif^aniont on one side. The enrettinji; entailed a larpe openintr in Donirlas's poudi. I then jHirfornied vajjinal hvsterectoniv. The patient made an excellent primary recovery, but the cancer, of course, continued developing. 544 DISEASES OF WOMEN. Periiianganate of potassium (enough to give the water a dark purple color) has no odor at all, but stains the linen. Peroxide of hydrogen has neither wlor nor color, and has a high disinfecting power. Small tampons dipped in terebene and olive oil, equal parts, may be left in place for two or three days. Equal parts of iodoform and charcoal applied as a powder on the ulcer relieves pain, cleanses the ulcer, and combats the odor, but has a smell of its own that to many persons is objectionable. All these benefits may also be derived from the daily application of the odorless aristol. Suppositories with chloral and tannin (da gr. xv-.^ss) combat hemorrhage, pain, and odor. Occasionally the use of a styptic tampon (p. 184) may become necessary. For carcinoma of the body Yulliet's dilatation (p. 159), followed by curetting and chloride of zinc, may be used. Simple curetting, although less exact and powerful, is also very useful ; repeated every three to six months, it prolongs life considerably. The local use of calcium carbid is an important addition to our palliative resources, which in cases that have not progressed too far may even effect a permanent cure. Calcium carbid is one of the new combinations effected by Masson's electric stove. It is a brownish stone-like, very hard mass. A piece varying in size from that of the last ])halanx of the little finger to that of the thumb is placed in contact with the cancerous tissue in the vagina or in the uterus. A bubbling sound is heard and a foam seen, due to the development of acetylene gas. The vagina is rapidly packed with iodoform gauze, which may be left in place three or four days. Then it is removed. The calcium carbid is found transformed to a calcareous, clayish mass, which is scraped out with Kecamier's dull curette (p. 182) and incrustations removed with the finger. The sore is irrigated with lysol and dried carefully, and then a fresh piece of calcium carbid is applied. The three chief symptoms — pain, hemorrhage, and odor — are checked, and occasionally the whole cancerous cavity heals and contracts.^ In using tonics the reader should remember the warning (p. 245) against giving ii-on when there is any hemorrhage. So far, no drug has been found that will cure cancer, although from time to time some new specific is praised even by good observers. Some years ago it was condurango-bark ; then came Chian turpen- tine; next methyl bine enjoyed a short-lived celebrity. I have not seen any effect from the use of these substances ; but since others have ' Aime Giiinanl of Paris, Tribune Medirale, 1896, vol. xxvii. p. 827. J. IT. Ktlier- idwe, Jour. Ampr. Med. .i.s.wr., July 9, 1898, befran hy curetting and cauterization; but tlie original method of the inventor, Guinard, has the great advantage that it may be used in dispensary practice. DISEASES OF THE UTERUS. 545 claimed success, and since we must sometimes prescribe something, I add the following forrauhie : ^,. Extr. condurango, fl. 5ss ; Aqu., ad Sviij. — M. Sig. A tablespoonful four times a day. ^i. Extr. condurango, iss; Vaselini, §iss. — M. Sig. To be a])plied daily on tampons to the ulcerated surface. ^i. Terebinthinfe Chiensis, sss: Sulphuris sublimati, Siiss; Rad. glycyrrhizse, q. s. Ft. pil. No.' c. Sig. Three pills every four hours. To those who cannot swallow pills it may be given as an emulsion with mucilage, a yolk of an eg^, syrup, and sherry wine. Methyl blue is given in doses of 3 to 4 grains, once or twice a day, in capsules, by the mouth, or by the rectum. It is also injected into the tumor (TTLxx to .^j of a solution of 1 part to 300 pails of water), or the ulcer is covered with it in substance. As it stains every- thing, it is a disagreeable stuff to handle and to take. Injections of one-eighth of a grain of bichloride of mercury into the tissue retard the extension of the disease and clean ulcers, proD- ably by obliterating lymph-vessels and killing some microbe: ]^. Ilydrarg. cliloridi corros., gr. iij ; Sodii chloridi, oj ; Aq. destill,, 5j. M. S. — 20 minims for parenchymatous injection, three times a week.' Radicfil Tredhacnt. — Although some of the heretofore-mentioned methods have been claimed to have eflected a complete and perma- nent cure of cancer, we restrict the term " radical " to methods in which a cure is sought by surgical operations in the healthy tissue surrounding the disejiscd j)ai"t. In this connection we have to con- sider the supravaginal aiiii)utation of the cervix, and total extirpa- tion of the uterus. Tke high cervix ampndition (Schroeder's method) has been described on p. 448. It is not an easy ()j)cration, exposes to the danger of con- si(l(!rable hemorrhage, and is less rational than the total extirpation of tlie uterus, since we iiave seen that cervical carcinoma often is (•oini)ined with a beginning of the same disease in the bodv of the womb. Tlie whole cervix has also been cut out with the fhcnno-cdiilcri/, by ' Scliiiiiiiiii, Ct-ntntlbl./. (iijndk., 1>S8S, vol. xii. p. 'Jl.'!. 546 DISEASES OF WOMEN. which means hemorrhage is avoided, but neighboring organs may be implicated. Thennal galvano-cauterizafion seems to have given better resuhs, both in regard to mortality and the length of time before a relapse oc- curred, than any other method.' It is performed with the cautery loop, the cautery knife, and the dome-shaped burner (p. 252). At least the whole cervix should be removed. If the uterus is immo- bile, the supravaginal amjiutation is made with the cautery knife, not the loop (Fig. 303), and thorough cauterization of the bottom, sides, and edges of the excavation is added.^ The need of a costly instrumentarium and its liability to get out of order have undoubtedly prevented this method from becoming more popular. The total extirpation, or hysterectomy, may be jierformed by the vaginal, abdominal, vagi no-abdominal, sacral, perineal, or perineo-vaginal section. Vaginal hysterectomy is a German operation that has met with much opposition in this country.'^ The bad results are, however, probably due, in a great measure, to the fact that it has been undertaken when the disease had progressed too far. It is contraindicated if the carcinoma is not strictly confined to the uterus proper. The uterus should be freely movable, and an exam- ination under anesthesia should not reveal any infiltration of the broad ligaments or of the pelvic glands. But even with these restrictions relapses, as a rule, come sooner or later, the probable explanation being that at the time of the operation there is already an infiltration of the surrounding parts which cannot be felt. A. jNIartin has, how- ever, tried to prove by statistics that the permanent— or rather final — results are as good after extirpation of the cancerous uterus as in operation for cancer in any other part of the body, but at the end of five years all his patients were dead. Modus Operandi. — The operation may be performed with ligatures, pressure-forceps, thermo-cautery, or galvano-cautery. In order to ' Statistics of a large personal experience have been published by Pawlik of Vienna and John Byrne of Brooklyn, N. Y., Gynecol. Tran.'<., 1889, vol. xiv. p. 90. Dr. Bvrne's batterv and instruments niav be obtained from Mr. Kaysan, 34 Bond St., Brooklyn, N. Y. '■^ John Bvrne, Amer. .Jour. Ob.4., Oct., 1895, vol. xxxii. p. 559. ^ J. Bvrne, Gyn. Trans., 1889, vol. xiv. p. 90; ibid., 1892, vol. xvii. p. 3; Baker, ihi'l., 1891, vol. xvi. p. 170; Resimy, Gun. Trans., 1888, vol. xiii. p. 183; Jackson, Med. News, Jan. 18, 1890; Coe, ^Imer. Jour. ObsL, June, 1890, vol. xxiii. p. 587. Supravaginal .Xmputation of Cervix witli tiie gal- vano-caustic knife. DISEASES OF THE UTERUS. 547 avoid infection of the wound from the cervix or the interior of the uterus the latter should be cleaned with a disinfectant injection and the former cauterized. The ligatures and forceps may be used as described for the removal of the fibroid uterus (pp. 509-51 5). As the cervix usually is most affected Fig. 304. Bernays' Utero-tractor. and offers a bad hold for the traction-forceps, some instrument is needed that can take hold of the uterus from within. For this pur- pose Bernays' utero-tractor (Fig. 304), with its series of thick lateral projections, has proved very satisfactory in my hands. It is intro- duced closed into the cavity of the body of the uterus, opened, and traction made with it, in order to make the hooks penetrate the flesh. The use of pressure-forceps instead of ligatures is often necessary on account of lack of space, and is by many preferred under all cir- cumstances.' In order to avoid inoculation of cut surfaces with cancer germs, hysterectomy i'ov carcinoma of the uterus is of late often done with pressure-for<'cj)s and the thcrmo-cautery — so called tliermo-cduter- eviomy of the ntcriUH. First, the cancerous surface is cauterized with Paquelin's instrument and the vagina disinfected. Next, a trans- verse incision is made witii the cautery just below the bladder, the latter separated from the uterus with blunt instruments and fingers, and the wound cleaned with a strong solution of corrosive sublimate before the peritoneum of the vesico-uterine j)ouch is severed. Next, tlie posterior fornix of the vagina is opened with the thermo-cautery, and the mucous membrane! of the lateral fornix incised with the same. Pressure-forceps aie placed on the parametria and broad ligaments as described above, and the uterus cut loose with the thermo-cautery. - Still Ixitter than the th(M'mo-caiitery is the (/(ilirnio-cdiifcri/. This ' I do not know if it is ninre tlian ;tn :ic<i(lont tli:it I lost a ))ati('tit l)y totaiins who ha<l been doini; oxceilcntly until llif nintii day after tlu' i'Xtir|iatioii liy tlie ciainp method. Still, it has been siiriniscd that similar occiirrenrcs after ovariotomy and tlie extraperitoneal treatment of tlie pedicle after alKlominal hystereelomy for fibroids stood in some relation to the use of clamps and pins. 'J'he forceps has also caused the formation of a fecal fistula. Compare decubitus acutiis (p. 528). ' ('nitraWl. f. Gyniik., \H'J'), So. 21, vol. .xix. p. 5GU. 548 DISEASES OF WOMEN. instrument gives off much less nuliating heat, so that the neighboring parts are not so easily injured, and, on the other hand, it seems to exert a remedial influence on the tissue even at some distance. It is claimed that this method not only is characterized by absence of fever and pain, but that the scar shows a particular immunity from reappear- ance of the disease, and that there is an unusually long period of exemption before the disease reappears in remote organs.^ Mackenrodt goes so far as to demand the extirpation of the upper half or the who/e of the vagina in all cases in which the uterus is being removed on account of carcinoma. The reason is that there is great suspicion of the vagina being in a state of latent infection, and there is no means of distinguishing a healthy vagina from one thus affected. He uses tlie galvano-cautery. He begins the operation witli a lateral incision with tlie cautery-knife through the left vaginal wall and the perineum. Next, he seizes the edge of this incision with a forceps and dissects it off with the cautery up to the vaginal portion, rolls the vagina around the forceps, and burns it loose from the vaginal por- tion, proceeding first toward the rectum, then to the right side, then to the bladder, and finally back to the starting-line. If only tlie upper half of the vagina is to be removed, a circular incision is made with the cautery between the upper and lower half through the whole thickness of the vagina, and then the upper half is removed as described above.^ This method may, perhaps, be of value in preventing relapse, but it must entail a tedious convalescence, and lead to atresia or consider- able stenosis of the genital tract, and can, therefore, not be followed if the vagina is yet needed as an organ of copulation. After hysterectomy the pelvis and vagina are packed as described above (p. 513). The pregnant cancerous uterus has repeatedly been successfully re- moved in the second and third month by vaginal hysterectomy, which is particularly indicated under these circumstances. An accident that is not very rare in separating the bladder from the uterus is the formation of a vesicovaginal fistula. If such a thing happens, the opening in the bladder shoukl be closed at the end of the operation, and all precautions taken to insure healing (pp. 383, 385). If the attempt fails, and spontaneous closure does not occur, and there is no relapse, the fistula should be closed later. In order to gain room for the extirpation of the uterus, the peri- neum and the whole rectovaginal septum has been cut through in the median line, and healing by first intention has been obtained by means of silkworm-gut sutures (WincUel). Sacral Hijsterectomy. — 1. Kraske's Method. — Kraske's operation for ' John Byrne, Aiiu:r. Jour. Obttt., Oct., 18i)-'), vol. xxxii. pp. 5G5, 566. ^ Mackenrodt, Centralbl.f. Uyndk., I>9(i, vol. xx. ^'o. 5, p. 129. DISEASES OF THE UTERUS. 549 cancer of the rectum has been adapted to the removal of the cancer- ous uterus. The patient is placed in Sinis's position. A curved incision is made from the iliosacral synchondrosis on the right side to the tip of the coccyx. Then the gluteus maxiraus muscle and the great and le&ser sacrosciatic ligaments are detached from the sacrum. The coccyx is freed all around, and removed, together with the lower end of the sacrum, by sawing the latter bone through from between the third and fourth posterior sacral foramina on the right side to the left cornu. The rectum is loosened and pushed over to the left side. The peritoneum is incised close to the margin of the rectum, exposing the posterior surface of the uterus. The ligaments may now be tied and severed, and the uterus separated from tlie bladder. This operation is recommended in cases in which the uterus is large and the body of the organ fills up the j)elvis, or in which the ova- ries and tubes are the seat of prior disease and are adiierent.' The mortality is very great, and the wound heals very slowly, and is apt to leave fistulae. 2. Hegar's Method. — Hegar makes on the posterior surface of the sacrum a V-shaped incision with the base turned upward, cuts muscles and ligaments on the edges of tlie bone, detaclies the rectum, and cuts the sacrum with a chain-saw between the third and fourth sacral foramina in a slanting line, preserving the periosteum on the posterior side. The end of the sacrum is not detached, but only thrown upward, and later replaced. In regard to the whole procedure of sacral hysterectomy it may be said that a cancerous uterus that cannot be removed by the vagina is not fit for extirpation. Abdominal iri/derectomj/ (Freund's 3fethod) for carcinoma was at first attended with such extreme mortality that the operation was universally abandoned, and was only used as a necessary addition to vaginal hysti.'rcctomy (rdf/ino-ahdoinina/ hyHtcrcdomy) when dillicMil- ties were encomitered which could not be overcome in any other way. Still, from the ready ac(!ess it gives to all the pelvic organs, it is ])re- f(!nihle to the sacral mc^thod. And the great success ()btaine(l with abdominal hysterectomy for fibroids of the ut(!rus has induced some operators to j)erform abdominal hysterectomy for cancer also. It offers the advantage that one can remove more of the broad ligaments, and thus come further away from the seat of the disease. It has (!V('n i)('(>n recommended as routine pra(!tice to extirpate the iliac glands, in analogy with what -is (lon(! with th(> axillary glands in amputation of the i)reast.^ \\y ])reviotis iutrodnction of llexible ' Details may he foiiiKi in a paper hv E. K. Moiitgonierv of I'liiladeliiiiia in llie Trmnt. of llif Amrr. Akxhc. nj ()hKh'triritinH and (ii/iK'niliiiilsttt, IfSDI. " K. iiii'ii, Zeitscli. /. G»-buiUfi. u. Gyniik., vol. xxxii. No. 2. 550 DISEASES OF WOMEN. cathotors into the ureters by Kelly's method (p. 163) these organs may be avoided. Fennco-caginal Hysterectomy {Sclmchardf s Method)} — The same advantages are, iiowever, claimed for the perineo- vaginal method, which is particularly adapted to cases in which one of the broad ligaments is involved in the cancerous degeneration. The patient is })laeed in the dorsal position with drawn-up feet. On that side on which the ligament is affected an incision is made from a point be- tween the middle and posterior third of the labium majus, encircling the anus at the distance of two finger-breadths, and ending about the level of the tip of the coccyx. This incision is deepened, especially in its anterior part, in the adipose tissue of the ischio-rectal fossa, until the w\all of the vagina is exposed. Next, the whole vaginal Mall is split from l>elow up to the cervix, and after that the operation is the same as in common vaginal hysterectomy with ligatures — cir- cular incision around the cervix, opening of the pouch of Douglas, severance of the ligaments, separation of the bladder from the uterus, only with this difference, as it is claimed, that everything is done with the greatest ease, and that all ligations are made under the guidance of the eye. Both ureters can be extensively laid free, and even diseased parts of the bladder may be cut out. The incisions are only made on one side, and the wound heals by granulation in three weeks. If the uterus is movable and any part of it is cancerous, the whole organ, in my opinion, should be removed, together with the append- ages. If it is immobile, a suitable palliative treatment up to extir- pation of the cervix is indicated. In order to be able to extirpate cancerous glands from the pelvic floor it has been advised to ligate the anterior division of the internal iliac artery, which normally gives off the superior vesical, the vaginal, the uterine, the obturator, the middle hemorrhoidal, the internal pudic, and the sciatic arteries, and by the ligation of wiiich the sur- geon would be enabled to work in a bloodless field. But tlie internal iliac artery and its branches are subject to many variations. Frequently there is no separation into an anterior and a posterior division, or the anterior division may be so short that it cannot be ligated. It would, therefore, be necessary to tie the whole trunk of the internal iliac, which can be done. It lies between the upper end of the sacrum and the upper end of the great sacro-sciatic notch, and is usually an inch to an inch and a half in length, but sometimes it is only half an inch long.^ It lies at the inside of the psoas muscle, under the peritoneum. The vein lies behind it and somewhat to its inner side, the ureter in front and to the outer side (Fig. 84, p. (So). ' Centralbl.f. Chirun/ie, 1894, No. 'di), Beilage, p. 61. * " Quain's Anatomy," 9th ed., 1882, vol. i. p. 451. DISEASES OF THE UTERUS. 551 The obturator artery is especially erratic, not unfreqnently arising from the posterior division of the internal iliac, and sometimes from the external iliac or the epigastric, which is of so much more import- ance as the obturator gland is more liable to be affected than any other. But when once glands are aifected there is no telling how far the infiltration extends, and under such circumstances it is better to desist from operation. F. Papilloma. Under the name of papilloma many different tumors have been described which have in common a dendritic, digitate, or villous shape. Most of them are simply a form of carcinoma of the cervical portion — Clarke's cauliflower excrescence (see p. 536). Others are fibroid polypi (p. 496), formed by increase in size of the papillae of the cervix, and are generally covered with stratified flat epithelium. They have a pedicle comj)osed of connective ti&sue and muscular fibers. Others, again, contiiin glands, and belong, therefore, to the mucous polypi (p. 427). Others, again, are sarcomas that have taken the papillomatous form (p. 532). Some, finally, are t7'ue papillomas. In these the tumor is formed by hypertrophy of the papilla? of the vaginal portion. It contains highly dilated capillaries and larger vessels with very thin walls, but no epithelial elements. It gives rise to a profuse watery discharge and hemorrhage, but the general health does not suffer much, and if the growth is removed by an operation in the healthy tissue, no relapse follows. But when these tumors become old, epithelial ele- ments a})pear in them, and they tai<e on the structure of epithelioma. This true papilloma is likewise found springing from the nuicous membraue of the body of the uterus, but is exceedingly rare in that locality. Treatment. — True ])apilloma is to be treated by amputation of the cervix, or, if situated in the cavity, by curetting and cauterization. G. Dnchondroma. Enchondroma has been found in the cervix, but is very rare. It should be removed by amputating the cervix. H. Tuberculosis. Next to tho tul)es, the uterus is the part of the genital tract which is most commonly the seat of tulu'rculosis. It may be j>rimary or .'<econ(Jary, and the latter may again spread from neighboi'ing organs or hc: due to infection through the blood. The disease is usually limited to the mucous membrane. It occurs in three forms — llic 552 DISEASES OF WOMEN. acute miliary, chronic diffuse, and chronic fibroid form. Of these, the chronic diffuse is by far the most common, and is characterized by the formation of cheesy masses. Tuberculosis is nearly always limited to the body of the uterus ; and, on the other hand, in a con- siderable portion of the few cases of cervical tuberculasis on record the disease did not invade the bcxly.^ Diagnosis. — Besides offering the symptoms of endometritis, the uterus is considerably enlarged, which is partly due to tuberculous infiltration, partly to hyperplasia of the normal elements. Knobs may be felt near the cornua. If the os is closed, pus may accumu- late, so as to form a fluctuating tumor {pyometra, p. 349). If it is open, caseous masses may be expelled from it. Shreds removed with the curette and examined microscopically may show bacilli and cells, as described on p. 307. As a rule, a tubercular affection is at the same time found in the tubes and the lungs. Tuberculous ulceration of the cervical portion may be mistaken for carcinoma. Microscopical examination of a piece cut out from the neighboring tissue shows, how^ever, an entirely different structure in the two diseases — in carcinoma epithelial cells ; in tuberculosis small round cells, giant-cells, cheesy masses, and the bacillus tuberculosis. Treatment. — As to general treatment, the reader is referred to what has been said in speaking of tuberculosis of the vulva (p. 307). The local treatment consists in curetting and the application of iodoform. If the disease relapses and the general condition of the patient is not too bad, the uterus, together with the appendages, should be removed by vaginal hysterectomy. ^ J. Withridge Williams, " Tuberculosis of the Female Generative Organs," Johns Hopkins Hospital Report in Pathology, ii. Baltimore, 1892, p. 126. PART Y. DISEASES OF THE FALLOPIAN TUBES. CHAPTER I. Ma lform ations. The tubes are sometimes unusually large. In most cases this increase in size is due to the presence of some aMominal tumor, with which the tube is connected and grows in length and width. But even apart from any such complication it has been found to measure six inches and a half in length. One tube may be longer than the other. Sometimes the lumen is so large that a uterine sound can pass it, and then, of course, also fluid. Intra-uterine injections should, therefore, be administered in the dorstil position only, and with sufficiently dilated cervical canal, unless a double-current tube is used (p. 178). They may be wound in a spiral or be abnormally contorted, condi- tions which predispase to retention of fluid, inflammation, and extra- uterine pregnancy. Tliere may lie from one to three accessory abdominal ostia. They are surrounded by fimbriae and situated near the abdominal end of the tube, on the uj)per part of the wall. There may also be ticccssori/ tubes, either as cystic diverticula starting from the tube, but without communication between the two cavities, or as independent tubes with fimbria? starting from the meso- salpinx. In the latter variety ectopic gestation may take place — paratubal pregnancy} The tulx!S may be absent, on one or both sides, which is due to a destruction of the corresponding part of the Miillerian ducts in the embryo. In other cases there may l)e a partial or totiil absence of tunneling of the tubes, the result of an arrest of development (p. 30). In otliers, again, the tube is normal near the uterus, but is soon lost in the con- nective tissue of tlie broad ligament. The corres[)onding ovary is usually absent or little developetl. Deficient development of the tube may be the cause of })ain at the menstrual j)eriod, and hw-al peritonitis, when ovula and 1)1(xk1 from the Graafian follicles fall into tiie alxlominal cavity. ' yiinger, MomitJischr. f. GeburhMil/e uiul Gyruikologie, 189o, vol. i. No. 1, p. 25. 554 DISEASES OF WOMEN. At the fimbriatetl end of the tube is often found a little cyst called the hydatid of Morcfagni. Its inside has a ciliated epithelium, and it is filled with a clear fluid. As a rule, it has only the size of a pea, but it may acquire that of an English walnut. It is not of surgical interest. CHAPTER II. Salpingitis. Salpingitis is the inflammation of the Fallopian tubes. Diffei'ent Forms. — ^^It may be acute catarrhal or acute purulent, both of which are seated in the mucous membrane, and are, therefore, called endosalping'dis ; or it may be chronic interstitial, which is also called pacht/salpinc/itis, mural salpingitis, myosalpnngitis productivay or parenchymatous salpingitis, and is located in the muscular coat. Salpingitis may be cystic, and according to the character of the fluid contained in tlie dilated tube it is called pyosalpinx when the tube is filled with pus, Jiydrosalpinx when it contains a watery fluid, or hematosalpinx when the contents are bloody. Perisalpingitis is the inflammation of the peritoneal covering of the tube, a condition which only occurs as part of a more extended pelvic peritonitis. Proflucnt salpingitis is only a variety characterized by the discharge of a Matery fluid, pus, or blood from the tube through the uterus and vagina. When the fluid is watery the disease is also called hydrops tubce prqfluens or intermittent hydrocele of the ovary (Bland Sutton. See Tubo-ovarian Cysts in the pathology of the Ovaries.) Under the name of Scdpingitis isthmica nodosa has been described a form of chronic salpingitis in which nodules can be felt at the cor- ners of the uterus. In their interior is found the tubal canal, hyper- plasia and hypertrophy of the muscular elements of the wall, and sometimes cysts. Pyosalpinx saccata is a variety of pyosalpinx in which the lumen of the tube is partitioned ofl" into a series of pus-filled sacs, which partitions may subsequently become absorbed, so as to form one cavity. Taking the etiology as base for a classification, salpingitis may be divided into infectious and non-infectious. The non-infectious is always catarrhal ; the infectious is nearly always purulent, but may in the beginning or toward the end of the disease be catarrhal. Paihologiccd Anatomy. — One or both tubes may be diseased. The infectious form is usually bilateral. The tube is swollen to a thick- DISEASES OF THE FALLOPIAN TUBES 555 ness varying from that of a little finger to that of a thumb (com- pare below, cystic salpingitis). In catarrhal salpingitis the aifection is chiefly limited to the mucous membrane. The folds are edematous and hyperemic, or slightly infiltrated with small round cells. The epithelial cells are swollen, show slight increase in size of their nuclei, and vacuoles form in their protoplasm, Side-b randies grow out from the folds, and these, as well as the original folds, may grow together, forming closed cavities. The muscular coat does not participate much in the inflammatoiy process. The secretion is in- creased, and contains mucus, albuminoids, and thrown-oif epithelial cells. In purulent salpingitis the process is more destructive. The tubes are swollen, often distorted, adherent to neighboring organs, and sometimes divided by internal partitions or external bands into a series of compartments, which give them a beaded appearance. The epithelial cells lose their cilia. The e])ithelium is thrown oif over large areas, and the underlying tissue is crowded with small round cells, which are thrown oif as pus-corpuscles. Commonly the mucous membrane is the primary seat, but by extension the inflammation invades the muscular coat, and tiie coinicctive tissue between the muscle-i)undles becomes infiltrated with pus-corpuscles. Probably tears of the cervix and pelvic cellulitis may also lead through the lymph-vessels to infiltration of the tube. The fimbriic become agglu- tinated to one another or to the ovary. In the beginning the ostium uterinum may remain open, constituting a profluent purulent salpin- gitis. If purulent salpingitis is cured, it leads to a temporary or perma- nent hypertrophy of the wall by formation of new connective tissue. Interstitial salpingitis is a chronic disease which has its scat in the muscular coat.^ It may follow either catarrhal or purulent sal})in- gitis. The extension from the nuicou-^ membrane to the muscular layer takes place through the connective tissue. In the fii'st stage the connective tissue between tlie muscle-bundles is edematous. Next, a large number of inHammatory corpuscles (small round cells) form in it, and even the smooth nuiscle-fibers themselves break down and are transformed into such cells. Later, the interstitial inflammatif)n may lead to the formation of new connective tissue. Jt is doubtful if iiniscular tissue is also formed. In this way the wall is thickened, and the prwess may end in a permanent hypertrophy (Fig. .')();")). On the otlier hand, interstitial salpingitis may lead to atrophi/ of the tube. Here the wall is thin, the caliber small, and the e})ith('lium partially lost. The muscle-tissue is to some extent replaced by con- nective tissue. ' II. J. T>oI(lt lias iiiiulc a sj)e(ial study, illiisf ratid by instriiclivc dr.iwiiifrs, of tlio microscopical changes characleristic of this form in Ama: Jour. Ohft., I'ch., 188S, vol. xxi. p. Vl'l. 556 DISEASES OF WOMEN. Fig. 305. Hypertrophy of Fallopian Tube due to Interstitial Salpingitis. The tube is cut open, showing the lumen, a, in the middle of the thiclc hard wall, 6.1 Fig. 306. Salpingitis: a, tube finger-thick at lower end, narrowed in many places ; 6, cyst as large as a chestnut situated in the wall of the tube ; c, ovary containing a recently ruptured Graafian follicle, the size of a large hazelnut; d, torn adhesions.^ ' Specimen from my salpingo-oopliorectomy on Mrs. S., in St. Mark's Pfosiiital, on July 24, 1890. ^ Specimen from my salpingo-oojiliorectomy on Mrs. L. S., in St. Mark's liostatal, on August 29, 1890. DISEASES OF THE FALLOPIAN TUBES. 557 The different forms of salpingitis, aspeeially the purulent, ai'e often accompanied by pelvic peritonitis, due to an extension of the inflam- mation through the wall of the tube to its peritoneal covering, or to the entrance of irritating fluid into the peritoneal cavity through the ostium abdominale. In most cases the ovary becomes implicated in the inflammation. It is full of small cysts or may form an abscess. An exudation is formed in Douglas's pouch or around the tube and ovary, which are then matted together into one globular mass. Ad- hesions are formed to the intestines, the omentum, the bladder, the uterus, the broad ligament, or the wall of the pelvis. The loss of epithelium and growth of new folds springing from those normally formed by the mucous membrane may lead to closure of the Fig. 307. 1. Left Tube cut open, f'atarrlial and Interstitial Salpingitis: a, closed fimbria'; a h, a c, thickness of wall ; d, central cavity. 2. Right Tube cut oirti, I'yosalpiiix : a, closed fimbriic; b, cavity filled with pus; c, c, r, smaller cavities coinmunicatiMK with central canal. S. Small round body found loose in pelvic cavity, probably atrophic right ovary .i ends of the tube or coalescence between the walls 'u\ one or more places in their cour.-e. As a rule, the abdominal opening is first closed by agglutination between the fiml)ria3 or between them and tlie ovary. Later, agglutination may also take place at the uterine end. If both ends are closed, the fluid ac(;umulates, forming a cyst, filled with a serous, mucous, pultaceous, purulent, or l)Io(Kly fluid. The wall is in most j)laces thickened, but through distention or ulceration in the interior it has thin })laces liable to rupture. Most ' Specitrieii from mv salpingo-tx'ppliorectomy on Mfh. F. K., in St. M:nl< .« Ilospi- tal, on May 19, 1894. ' 558 DISEASES OF WOMEN. frequently this thinning is found in the upper and posterior part of the tube, so that the fluid, in ease of rupture of the wall, flows into the peritoneal cavity. In rarer instances the rupture takes place downward between tiie folds of the broad ligament and produces pelvic cellulitis and abscess. These tubal cysts are mostly club-shaped, Avith a thinner inner end and a thicker outer. Sometimes they are more pear-shaped or round, or form a string of alternating wide and narrow parts, like a string of sausages (Fig. 306). Diflferent forms may be found simultaneously in the same individual. Thus I have seen pyosalpinx in one tube, the fluid being purulent with a few columnar cells, while the other tube showed marked interstitial and catarrhal salpingitis, the much distended canal being filled with a putty-like mass exclusively com- posed of ciliated columnar epithelial cells (Fig. 307). Frequency. — Salpingitis is a very common disease. Etiology. — Salpingitis is hardly ever a primary disease. As a rule, it is secondary to inflammation of the uterus or the peritoneum. The inflammation may follow the mucous membrane or be propagated from the uterus through the lymphatics of the broad ligament. The disease is nearly always limited to the period of genital activity. It is quite frequent in prostitutes, causing colica scortorum ; and unfor- tunately, it appears often in newly-married pure women. Malformations, such as atrophy, a spiral twist, and angles in the course of the tubes, predispose to their inflammation. Salpingitis may be due to infectious and exanthematous diseases, such as cholera, typhoid fever, scarlet fever, and smallpox. It may be brought on by flexion, myoma or carcinoma of the uterus, and perhaps stenosis of the os, with retention of mucus in the cavity, or by ovarian disease. It may be caused by exposure to cold, violent exercise immediately before menstruation, or too frequent coition. But in the large majority of cases salpingitis, and that in its worst form, the purulent salpingitis, is either gonorrheal or puerperal. If gonorrhea once invades the uterus, it has a great tendency to spread to the tubes. Puerperal salpingitis is found as part of the affections cha- racteristic of puerperal infection or of incomplete abortions, in which the ovum or the spongy decidua is allowed to remain in the uterus. In rare cases the presence of actinomyces is the cause of sal- pingitis. Purulent salpingitis may also be due to gynecological treatment, not only operations, such as incision of the cervix ; but the mere intro- duction of a sound or the administration of an intra-uterine douche may, in rare cases, lead to salpingitis or change a comparatively harm- less catarrhal into a purulent inflammation. Symptovis. — There is no pathognomonic symptom. Even a dan- gerous puerperal salpingitis, calling for removal of the pus-filled tubes. DISEASES OF THE FALLOPIAN TUBES. 559 need not cause any other symptom than emaciation and recurrent fever. A symptom, however, that must awaken great suspicion is an intermittent outjiow of mucous or purulent fluid irom tlie genitals, but the same may sometimes be due to endometritis. The patient is, as a rule, sterile, or has had one child, so-called secondary sterility. The disease is, in most cases bilateral or, if only found on one side, the left is more likely to be aifected, a peculiarity which may have its cause in the preponderance of cervical tears on this side (p. 415) or the absence of a valve in the left ovarian vein (p. 77). Pain may be insignificant or excruciating. It is felt in one or both iliac fossa and in the sacral region. It often has a colicky character, and may be due to contraction of the inflamed nuiscular coat or to pressure on the ends of nerve-filaments. In other cases the pain is burning. If only one side is affected, the pain is sometimes felt in the opposite side. It is increased by any kind of exertion, so that the woman becomes unable to do any kind of work ; and it is much enhanced by coition. It is worst at the menstrual period. Leucorrhea is common. Often the ])atient suffers from menorrha- ffia or metrorrhagia, the hemorrhage taking place in the diseased tubes themselves or in tlie uterus, the endometrium of which may be inflamed. Periods of menorrhagia may alternate with others of amen- orrhea. The general health suffers, the patient loses flesh and strength, becomes nervous, and often has fever. By vaginal examination tlie tubes are found tender, thickened, often distorted and either movable or adlierent to neighboring organs, Very often the ovary is felt enlarged and tender, or there may be an' exudation or new-formed connective tissue matting it and ])erliaps a knuckle of intestine and a part of the omentum, together with the tube, into one sliajx'less mass. A unilateral mass of this kind may so fill the pelvis as to push the uterus over towardthe other side, at tlie same time canting it forward. In ca.se the masses are bilateral and large, they ])ush the uterus with the broad ligaments from behind forward up against tlie anterior wall of the pelvis, or j)ress on it more from above, tipj)ing it forward into complete anteversion. In other cases again the uterus is found retro- flexed and often adherent to the posterior wall of the pelvis. JJiar/notiiH. — The diagnosis of salpingitis may be very diflicult, the di>- ease being so often combined with oophoritis, peritonitis, and cellulitis. The intermittent spontaneous outfiow of nuicus or ])us ])receded by a burning sensation or cramps makes the })resence of salpingitis veiy probaiile. Tiiis symj)tom actpiires still more weigiit if the examiner by gentle pressure exerted on the tui)al region can make the fiuid appear at th<; os uteri. (Jophoral(/i(f is oidy found as a ])art of general hv>teria ; luinho- ahdoniinal 7U'iir(il(/i(i is elicited by j)ressure on the skin over the iliac 5G0 DISEASES OF WOMEN. region, but not by pressure from the vagina, and in none of these purely nervous affections is there any swelling. From oophoritis the inflamed tul^e is distinguished by its shape, and sometimes the ovary can be felt beside the swollen tube in a normal condition, or only slightly enlarged and tender compared with the swelling formed by the tube. Cellulitis forms a swelling situated lower down than the swollen tube. Peritonitis form?, as a rule, a larger exudation of more globular shape extending from Douglas's pouch to one of the iliac fossse. Sometimes it is hard to tell a swollen tube from an intestinal knuckle felt in Douglas's pouch, but the latter is not particularly tender, is not always present, and is sometimes empty, while at other times it contains feces. In order to obtain full knowledge of the condition of the tubes, it is necessary, besides the common examination in the dorsal and Sinis's positions and by rectal touch (p. 144), to anesthetize the patieiit, place her in lithotomy position, let the legs fall out, so as to put the psoas muscle on the stretch, introduce the fore- and middle fingers of one hand into the lateral vault of the vagina, and depress the ab- dominal wall with the other. The vaginal examination is performed W'ith the left hand for the left side of the pelvis, and the right hand for the right side. A purulent salpingitis may be surmised if the history reveals gon- orrheal or puerperal infection, and the purulent nature of the fluid in the tube, together with the permeability of the ostium uterinum, is proved if pus am be made to appear at the os uteri by the above- mentioned manipulation. Prognosis. — Salpingitis is a serious disease. Its course is usually a tedious one. It may end fatally from exhaustion ; it may cause sudden death or make the patient an invalid for life, and it very often entails sterility. It is especially the purulent form the prognosis of which is so doubtful ; the catarrhal is more amenable to treatment, less protracted, and less dangerous. Treatment. — Prophylaxis. — Women should be sufficiently clad (see p. 130) and avoid sudden refrigeration when heated, especially during the menstrual period. As far as possible they should avoid marriage with a man who has or has had a gonorrhea which is not perfectly cured ; or to put it the other way, a man with gonorrheal threads, designated with the Ger- man name " tripj>er faden," in the urine, or at whose meatus urina- rius appears a little secretion in the morning, should not marry unless the discharge is free from pus, and when even a purulent discharge, artificially produced by injection with nitrate of silver or corrosive sublimate, does not contain gonococci (see latent gonorrhea, p. 133). DISEASES OF THE FALLOPIAN TUBES. 661 Childbirth should be surrounded by all antiseptic precautions.^ In cases of incomplete abortion the uterus should be emptied immedi- ately. If salpingitis is present, the doctor should abstain from making an incision in the cervix, introducing an intra-uterine pessary, using in- tra-uterine injections, nay, even from carrying a sound into the uter- ine cavity, as all these interferences may give new impetus to the disease or change a catarrhal salpingitis into a purulent, and lead to death. Curative Treatment. — In acute salpingitis we prescribe absolute rest in bed, fluid diet, an ice-bag on the lower part of the abdomen, opium suppositories (p. 243), hot vaginal douches (p. 176), and, if necessary, a saline aperient (p. 242). Hot rectal injections serve both to move the bowels and combat the inflammation. If the inflammation is unmistakably purulent and gives rise to serious symptoms, it is safer to remove the appendages immediately without losing any time in palliative treatment. In the chronic form much may be accomplished by mild treatment, if the patient can take care of herself. It is often well, even in this form, to begin with confining the patient to her bed for three or four weeks. Painting internally and externally with tincture of iodine (pp. 174 and 196), pledgets soaked in ichthyol-glyccrin (p. 182), gal- vanism with one pole against the vaginal vault (p. 249) or in the uterine cavity (p. 248), preferably the former, scarification of the cervix (p. 194), intra-uterine applications of chloride of zinc (p. 175), blisters applied over the inguinal fossa, superficial cauterization of the same region with Paquelin's cautery, poultices, hot^ water bags, Pricssnitz compresses (p. 195), and warm entire baths, — are all very eff<'ctive remedies, which, combined with substantial food, mild stimu- lants (p. 241 ), and tonics (p. 242), may efl'ect a cure. In milder cases of swollen tubes and ovaries, curetting (p. 180), followed by pac^king of the uterine cavity with iodoform gauze (p. 185), has proved very beneficial in the writer's hands — an effect which probably must be attributed to the depletion from the surroundings due to the drainage from the uterus. Others think they can evacuate fluid from the tube by dilating the uterus, curetting, especially around the openings of tlie tubes, and packing with iodoform gauze, to be removed every day or two. MuHHage (|). 199) has also been praised, but seems to me to be sur- rounded by too great dangers. '\\\i\ only indication I see for it is the cases in which the abdominal opening of the tube is closed, and the ' V\\\\ information in this respect is found in the writer's Prartiml fhiiilr In Aiill- Sfjylir Midviff-ni in IIuspilnlH and I'rivdtr I'rnrHcf, Hetroit, Mich., 1SS(>. jiixi in his articit^ on " I'iier[)eral Infection" in Amrr. Si/slrvi of Ohxlt'lrint, I'hiia., iSSit, vol. ii. I){). 3'.i7-;'>f)l, and in Avur. Text hook of OhsMnrs, I'fiiia., IS!)."), i)|.. TOS 719. 36 562 DISEASES OF WOMEN. uterus renmius opeu. Uudcr such cirounistanees a very gentle press- ure followiug the course of tlie tube froui without inward toward the uterus may press out the fluid whicli has accunuilated in tjie tube. But the diagnosis is not easy to make on the living, and if the abdom- inal ostium was just a little agglutinated, the pressure might reopen it and drive the contents of the tube into the peritoneal cavity. Intra-uterine injections should be avoided, as they are apt to increase the inflammation of the tubes. If these milder measures do not succeed, the tube may be attacked surgically from the vagina or through the abdominal wixW. Catheterization of the tube is in normal cases, and in most patho- logical ones, impossible. It has only been performed when the ute- rus was Literoflexed and the ostium internum much dilated, or in cases of abnormal width of the tube (p. 553). In otlnir cases of supposed catheterization the sound has perforated the uterine wall, which is easily done, and, as a rule, has no evil consequences (com- pare p. 181). Aspiration through the vaginal vaidt is not devoid of danger, not only on account of the organs that may be wounded with the needle, but still more on account of the nature of the fluid that after its withdrawal may drip into the peritoneal cavity. It should, therefore, only be used if the swelling is situated in the posterior half of the pelvis, so low down that it is within easy reach, and when it seems so flrmly adherent in Douglas's pouch that we have reason to hope that no fluid will escape into the j)eritoneal cavity. Besides, as a rule, aspiration will have greater value from a diagnostic standpoint than from a curative. It is most likely that the diseased mucous mem- brane of the tube will reproduce a similar fluid. xVn incision may be made from the vagina, a method es])ccially indicated in acute puerperal cases, where the patient is too weak to stand salpingo-oo])horcctomy or hysterectomy.' A transverse in- cision is made behind the cervix as for hysterectomy. With the finger and l)lunt instruments the operator approaches the tubal swell- ing as much as possible, and then opens it with the expanding per- forator (Fig. 177, p. 199). The cavity is either ])acked with iodo- form gauze, or a soft-rubber drainage-tube with cross-bar (Fig. 169, p. 193), and long enough to protrude from the vulva, is placed in the tube. A safety-])in is inserted at the lower end, and iodoform gauze wound round tube and pin, so as to close the tube without preventing drainage. This method should, however, only be used if the conditions mentioned in speaking of aspiration are ])r(>s(nt ; and, as a rule, if the diagnosis is sure — that is, if the fluid is in the ^ The writer has successfully opened five distinct pus collections in a puerper;i, corresponding to abscesses in tioth tubes, both ovaries, and encysted peritonitis, from the vagina. DISEASES OF THE FALLOPIAN TUBES. 563 Fallopian tube, and not in the peritoneal cavity or the connective tissue of the pelvis — the tube should be removed. In all cases that have withstood the palliative treatment for four months or longer, an exj)lot'atory laparotomy or colpotomy is indicated, whicii may lead to the removal of the uterine append- ages with or without the uterus, or to their preservation by diifer- ent means. Laparotomy, or abdominal section, is described under Ovariotomy. Colpotomy, or vaginal incision, may be made either in front of the cervix — anterior colpotomy — or behind it — posterior colpotomy. The modus operandi is exactly the same as for the first steps of vaginal hysterectomy (p. 511), or, so far as anterior colpotomy is concerned, more room may be gained by following the rules laid down for vaginal fixation of the round ligaments (p. 475). The conservative treatment is now mostly carried out by vaginal section. Conservative Treatment. — In some cases it suffices to separate adhe- sions, ]>ass a probe tlirough the whole length of the tube, wash it out from the fimbriated end with a weak solution of bichloride of mer- cury (1 : 5000), and stitcli the fimbriae to the peritoneum near the ovary, so as to prevent them from curling in and closing the abdom- inal opening again. If the fimbriae cannot be separated, the end of the tul^e may be cut off, and the mucous membrane stitched to the peritoneal coat with a few catgut sutures. By tying the mesosalpinx without comprising the tube in the ligature, more or less of the latter may be removed and yet a passage left for an ovulum from the ovary to the uterus. Several cases of pregnancy under such circumstances have been reported. At the same time it may be necessary, in order to prevent reformation of torn adhesions, to perform abdominal hys- tero])exy (p. 474) or shortening of the round ligaments (p. 471). Such conservative measures have even Ix'en successful wh(>n the tube con- tained from a half to a whole fluidrachm of pus. Where there is a large collection of fluid, the tubes should be removed.' Halpiwjo-o'nphorectomji. — Indications. — In acute sal))ingitis the re- moval is contraindicated excej)t when a purulent salpingitis extends to tiie peritoneiun and threatens to l)Of!ome generalized. Under such circumstances tiie extirpation should l)e performed immediatelv, with- out losing time with j)alliative measures. If at the same time tiiere is a ])urulent discharge from the uterus, this organ ought to be cu- retted or removed. Tlie removal of tlie apj)endages is also indicated fi)r interstitial sal- pingitis, if the j)atient sufl'ers much pain and has repeated attacks of ' I'olk has (lone miidi in tho line of conservatism, and descrihed his i)roc(>(iiire8 in Mediml Rermd, Sept. 1«, IHSO; Amn\ Jour. ()I>M., 18«7, vol. xx. |). ti.SO; Tmn^. AviPT. Gyn. Sor., 1H87, vol. xii. p. 128; Jonr. OhxI., Dec, IS'.tO; i7>i(/(?/i, Sept., IS'.tl; IVaim. Amer. Gyn. Soc., Wfd, vol. xviii. p. 175; Med. Neua, Jan. 4, 189(1. 564 DISEASES OF WOMEN. pelvic peritonitis, and for most cases of cystic salpingitis, especially pyo- and hematosalpinx. It is true, numerous autopsies have proved that pus can become in- spissated in the tubes to a puttylike mass, and, on the other hand, it can probably, by a process of clarification, be changed into a serous or mucous fluid, but such favorable events are too uncertain, and it is, therefore, safer to remove the tube, if it contains more than a very small amount of pus. If the endometrium shows signs of infection, it is advisable first to curet and drain (p. 180) l^efore performing salpingo-oophorectomy, and in this way the latter operation may sometimes be avoided. On the other hand, in general, the removal should not be under- taken as long as the uterine ostium remains open. Under all circumstances the consent of the patient must be obtained. The oif-hand way in which some operators spay a woman without her knowing it is not only unjustifiable on moral grounds, but exposes the operator to a suit for mayhem and heavy damages. 3Iodus Operandi. — The appendages may be removed through the abdominal wall or through the vagina : the former method is called Tail's operation, the latter BaMey's operation.^ The reader is referred to the general description of laparotomy given under Ovariotomy. Here we shall add a few points with regard to salpingo-oophorectomy. A. Abdominal salpingo-oophorectomy. — The incision is made in tiie median line, so low down that the lower end is half an inch above the symphysis. The upper end varies according to circumstances. In easy cases only room for two fingers is needed ; in difficult it may become nece&sary to introduce the whole hand, push the intestines up, and expose the whole pelvic cavity to view. When the small incision is made in the abdominal wall, the left fore- and middle fingers are introduced into the abdominal cavity. Pushing omentum and intestines up, the fingers are placed on the fundus uteri, and moved out along one of the tubes to the ovary. If tliere are no adhesions, the tube and ovary are lifted between these two fingers up through the abdominal wound. If necessary, this proced- ure may be facilitated by having the uterus lifted from the vagina by means of a dilator introduced into the cervix or simply with the fingers of an assistant, or by packing the vagina before the operation with gauze. In this and other operations in the depth of the pelvis the manij)- nlations may also be much facilitated, especially on the left side, l)y introducing a eolpeuryiiter — /. e. a rubber bag — into the rectum, and * Battev's operation was originally devised for the " extirpation of the functionally active ovaries for the remedy of otherwise incurable diseases" (Trans. Amer. Gyn. Soc., 1876, vol. i. p. 101), but has been much extended both as to object and method. DISEASES OF THE FALLOPIAN TUBES. 565 distending it with water. If oozing points are left in the pelvis after the operation, this same bag filled with ice-water and combined with abdominal compression may serve as a hemostatic plug working both by pre&sure and refrigeration. If the broad ligament does not yield, Tait gains room by making small tears in it with his nails near the pelvic wall. The peritoneum and connective tissue are torn, but the stronger vessels resist. The parts to be removed may also be seized beneath the surface of the body with suitably curved forceps, and ligated there, without being brought out through the incision. If there are adhesions they are cautiously torn, the surgeon, if pos- sible, relying on his sense of touch alone. Otherwise, they are lifted up into the wound and separated there. Sometimes it is necessary to enlarge the incision so as to make the whole pelvis accessible to the eyes and hands. The intestines are pressed up under the abdominal wall, and held there with a flat sponge or a gauze pad. In very ex- ceptional cases they are even pulled out through the opening, laid on the upper abdomen, and covered with a cloth wrung out of hot nor- mal salt solution f() : 1000). The elevated-pelvis ])()sition lielj)s much to avoid handling of the intestines, which is likely to cause shock and predisj)oses to adhesions after tiie ojK'ration. If the tube and ovary are imbedded in a mass of resistant new- formed tissue, it may be ne(!essary to desist from their removal ; but with increasing experience and skill an ojicrator will be able to remove organs which, at an earlier stage of his career, it was wise to leave undisturbed. Tait did not giv(; up the oj)eration even if it was necessary to wound bladder and intestine in order to finish it. The ensuing fistula heals spontaneously.' Sometimes serous fluid accumulates in the interior of adh(>sions, by whi(;h thev become tubular, and look much like a Fallopian tube or the appendix vermiform is. Vascular bands arc; often cut Ix^tween two catgut ligatures. When the tube; and ovary are lifted up, a dull handled needle (Fig. 202, p. 2?>\) threaded with a strong silk ligature (braided, No. 12), 20 inches long, is pushed from the front backward through the broad Iigan)ent, half to three-fourths of an inch under the ovaiy. An assistant seizes the ligature with a ])air of fbreej)s and his finders and holds it while the oj)erator withdraws the needle. Next, the loop is i)rought forward over the ovaiy and tube, comj)risiiig as nnKJi of the latter as feasible. One of the fre(^ ends is carried through this loop, the (jther remains above it. I'he opei'ator seizes both ends with the fingers of his right hand and ])ulls on them, and j)resses with his left thum!) and index finger against the tissue to be li- ' Lawson Tait, t'adratbldtt. Jar (lyndk., Keb. 4, 1893, vol. xvii. p. IKJ. 566 nrSEASES OF WOMEN. gated. He may also pull on one end alone, and have his assistant pull on the other, or, preferably, he may combine both these manipu- lations. The ligature is pulled very tight, Fig. 308. but slowly, so as not to break it, and then tied with a reef knot. This way of tying the ligature is called the Staffordshire knot (Fig. 308), because it is the badge of the county of Stafford in England. It is, however, safer and allows us to get closer up to the uterus Staffordshire Knot (Tait) to cut the ligature in the middle and cross the halves twice, as described under Ovariot- omy. From each side a pressure-forceps is put on the pedicle just above the ligature, and tube and ovary are cut off with small cuts made with a pair of scissors curved on the flat, taking care to remove all of the ovary and as much as possible of the tube ; and, on the other hand, to leave enough of the pedicle to prevent the ligature from slipping. Next, one of the pairs of forceps is removed, and a strong tenaculum or tenaculum-forceps inserted in its stead. Then the second forceps is taken off. If there is no bleeding from the stump, the ends of the ligature are cut short. If tliere is bleeding, the ligature is carried round the pedicle and tied on the other side. The cut surface is powdered with iodoform or aristol, or seared with the thermo-cautery, taking great care not to burn the ligature. Fi- nally, the tenaculum is removed, and the pedicle dropped into the pel- vic cavity. If there is too much tissue, it may be cut off under the tenaculum. Instead of thus including a large part of the broad ligament in the ligature, two separate ligatures may be placed, one on the ovarian vessels in the infundibulo-pelvic ligament and the other on the anas- tomosis between the ovarian and the uterine artery, just outside of the corner of the uterus. Then the ovary and the tube may be cut off. If, exceptionally, there is any bleeding, the bleeding point is secured by a sj^cial ligature. This method offers the great advan- tages that there is less danger of the ligatures slipping, that very little tiasue is compressed in the ligature, that all ovarian tissue can be re- moved, and that there is no traction on the scar.* Another good way is to place clamps inside and outside of the appendages, cut those out, tie the ovarian and the uterine arteries separately on the cut surface, and close the whole in- cision with a running catgut suture. If there is any bleeding, more clamps are provisionally put on and removed Avhcn they are reached by the suture. Then it is best to loop this for every stitch (p. 238). It should be remembered that the ovarian vessels at the brim of ' C. B. Penrose, Amer. Jour. Obst., 1895, vol. xxxii. p. 221. DISEASES OF THE FALLOPIAN TUBES. 567 the pelvis cross in front of the ureter, and care should be taken not to embrace this tube in the ligature. If the tumor is situated in the broad ligament, leaving the lower part of the same free, this may be tied in small bundles, between two ligatures, gaining access to the deeper portion by gradually cutting what has been tied. If there is no pedicle at all, the peritoneal cov- ering of the tumor must be split, and the tumor enucleated. This leaves a sac which is treated as described above (p. 526) under Fib- roids of the Uterus. As to the treatment of the appendages of the other side there is much difference of opinion. Tait recommended to remove them even if they were healthy, because they would be affected later, and the second operation had a mortality altogether disproportionate to the first proceeding, while many die for want of a second operation. But experience having shown that tiie removal of both ovaries often gives rise to great mental depression and piiysical disturbance (see J). 569), it is better, if the otlier set of appendages is healthy, and even if it is only moderately diseased, to try to save it, or part of it, so much more so as tliis has in rare cases permitted of pregnancy and childbirth.' The ovary may be cut open, (ysts enucleated or part of the ovary cut out, and the e<lges united by a continuous catgut suture. A piece of the tube may be cut off, and hemorrhage arrested by ligating the ala vesjK'rtilionis without interfering with the vessels nourisiiing tiie ovary. An ojxiuing may be cut in the tube, and the mucous mem- brane stitched to the peritoneum around it (p. 563). While the removal of non-adherent appendages is a comparatively easy oj)('rati(»n, it becomes one of tlie most dlflicnlt when there are many extensive and unyielding adhesions. Great benefit may, under these circnmstances, be derived from tiie elevated-pelvis position (p. 141). In attempting to free the adiierent a])pendages, we nuist try to find natural lines of ch'avage. Remembering tiiat the ovary s})rings from the posterior layer of the broad ligament, and that the tube is sit- uated at the u|)per border of the ligament and forms a ciu've around the ovary (pp. (j;3, 65), we nuist try to free them l)y going in Ix'tween them and the sacrum, behind the broad ligament. M' j)()ssible, the ligature shoidd be |)asse(l ix'low the round ligament, which lessens the danger of its slij)|)ing. For the same reason the broad ligament is shurkened in drawing the ligatures tight. If the tissue is so friable that the ligature cuts tiirough the tube and ligament, it may become necessary to tie the ovarian artery sej)arateiy and close the wound in the uterus with a nuuiing sutun; of" catgut. If" hemorrhage cannot l)e checked in this way, the uterine artery nnist be tied below, at ' Details arc found in papers l>y A. Martin, (Vntralhlatt jiir (ij/nii/:., Anno 20, 1891, Vol. XV. No. lio, J), ol"), and I'olk, Avkt. Jour. Obst., Dec, 1S9(), vol. .\xiii. ]>. i;?7r>. 568 DISEASES OF WOMEN. the upper end of the cervix on one or both sides, or the uterus itself removed. If the tube or ovary, or both, contain much fluid, it may be well to remove it with the aspirator, in order to avoid rupturing the append- ages ; but if feasible, the removal of the filled organs is easier. If a rupture occurs, which most frequently takes place in the upper poste- rior part of the wall of the tube, the fluid should be carefully wiped ofl^*, and a drain of iodoform gauze carried out from the contaminated area tiirough the abdominal wound or the vagina. If much of the pelvis becomes infected, the best plan is to fill the cavity with a Mikulicz tampon (p. 186), the eflect of which is that by exudation and organization of plastic lymph a temporary partition is formed between the pelvic and the abdominal cavity. If the fluid spreads widely among the intestinal knuckles, the whole abdominal cavity should be washed out with copious irrigations of hot salt solution, and a drain left in. If there is much oozing, a drain is likewise indi- cated ; or it may be necessary to apply a Mikulicz tampon (p. 186). If both appendages must be removed, it is best to remove the uterus also. This organ is often the source of infection of the others. It is not only useless after their removal, but often hemor- rhage and pain continue after removal of the appendages. Under such circumstances I have repeatedly been obliged to remove the uterus after months or years. The uterus may be removed by one of the methods descrilied above under Uterine Fibroid (p. 494 seq.), but Faure^s method is particularly adapted to cases of suppuration of both sets of adnexa with a small uterus. It is based on the principle that enucleation from below is easier than that from above, and applies it to both sides. After having opened the abdomen, the fundus uteri is seized with two pairs of traction- forceps, one on either side of the middle line. A transverse incision is made above the vesico-uterine pouch, and the bladder pushed down. Next, the fundus is divided in the median line with strong straight scissors, and with three or four clips the whole uterus is divided into two halves, whereby the vagina is opened in the median line in front and behind. Then one half of the cervix is seized, beginning with the side that seems easiest. If there is no difference, the right is taken first. This is pulled on, until a strong resistance is felt, formed by the correspond- ing half of the vagina. This is cut close up to the cervix, and half the uterus removed with its set of appendages. Afterward the same is done with the second half. The uterine artery is seized with a clam]) either before or after cutting it. The round ligament and the ovarian artery are seized and tied. If there are intestinal adhesions, they are separated last. By going from below upward the enuclea- DISEASES OF THE FALLOPIAN TUBES. 569 tion of the adnexa boconios mucli easier. The arteries are tied with catgut. The vagina may be closed or left open. Faure prefers the latter, and uses a thick tube and a strip of iodoform gauze for drain- age. For sterilizing the uterus, when opened it may be touched with Paquelin's cautery ;' or, preferably, it should be vaporized before opening the abdomen. If the vagina is closed, the whole wound in the peritoneum should also be closed as in supravaginal amputation of the uterus (p. 517). If only one set of appendages is removed, it is, as a rule, well to curet the uterus at the same time. The mortality after salpiugo-oophorectoray has, in Tait's hands, only been 2.5 per cent. The objection that the operation deprives the patient of the possibility of becoming a mother has not much weight, since in the large majority of cases she has proved to be or would be sterile on account of the condition of the ovaries and tubes. Her sufferings may be intolerable, and render it impo&sible for her to earn a living or perform any Jiseful work. Often they make an opium-eater of hei-. Now, in most cases, but, it must be admitted, not in all, the operation restores her to health and makes her again a useful member of her household and the comnuinity at large. Immediate and Remote RcHiUta. — In 8G per cent, the operation brings on the menopause at once or after a few months (compare p. 121). When menstruation continues it may be due to incompK'te removal of the appendages, irritation of the stumps, or disease of the uterus. As a rule, there is a discharge of blood for several days fol- lowing the operation, which is accounted for by the unusual congestion caused by the ligature cutting off the normal roads of circulation. In some cases a hematoma is developed in the broad ligament. Some- times, during convales(;enc(', or later, an encysted collection of serous fluid takes place in ])seudoniembraiies. Many complain of vertigo and fulne-s in the head, which may be relieved by bromides or cauterization with Patjuelin's thermo-cautery on the nape of the neck, or which may even necessitat<! repeated venesection. Purpura heiuorrhagica has been observed at the time when men- struation was due, but the operation does not give rise to vicarious menstruation. During the first week after the operation most patients c()in])lain of pain in tlu; pelvis, which probably is due to the constriction of the pedicle. In some this j)ain disaj)pears soon, and they feel relieved from their sufferings and bless the day they submitted to the opera- tion. In others this Iiapj)y event does not o(;cur before the la{)se of several moiuhs, and in a lew the j)ain j)ersists indeliniU'ly. This sad condition may be accounted for in ditl'erent ways. The chronic peritonitis had extende<l beyond the tui)es and ovaries, and part of it ' 1. L. I'aure, I'rc.isn mc'lirak, Urt. I'J, ISUT, vol. ii. p. 'S.i~. 570 DISEASES OF WOMEN. remains, therefore, after their removal. Tlie operation itself may lead to new peritonitis. New adhesions may form between the stump and its surrounding parts. In several cases a secondary ope- ration has shown that a cyst had formed near the stump on one or both sides. Adhesions to the bladder may cause a troublesome desire to urinate. Those to the intestines may cause pain, or give rise to intestinal occlusion. In some cases there is congestion of the uterus cjiusing pain, leucorrhea, or hemorrhage. The persistent pelvic pain is best treated with counter- irritation or galvanism, and sometimes a second laparotomy is performed and adhesions disposed of, or the uterus has to be removed, if it was not done when the appendages were taken out. The sexual appetite may remain unchanged, increase, diminish, or disappear. Many become fat and dyspeptic. Experiments on animals have shown that removal of the ovaries has a marked in- fluence on the metabolism. The phosphates eliminated in the urine and the carbonic acid contained in the expired air diminish, while tlie weight of the body increases. Whether the uterus is removed or not has no influence on metabolism.^ In a large percentage melancholia has developed, but alienists think they can account for it in other ways than by charging it directly to the lo&s of the genital glands and the cessation of men- struation. Even if the mental disturbance does not go so far as insanity, despondency, irritability, and laziness are quite frequently observed. Congestions of the head and thoracic organs and perspiration appear soon after the operation, and may continue with lessening fre- quency for years.^ Other disturbances that have been noticed are loss of memory, irritability of temper, diminution of the power of vision, a more masculine voice, skin aflfecticms, nightmare, and in- somnia.'* The functional troubles following the removal of both ovaries may sometimes l)e successfully treated by the internal administra- tion of powdered desiccated ovarian tissue — gr. ij in a capsule at midday. Perhaps even a radical cure and pregnancy may be obtained by the implantation of a piece of ovarian tissue either from the patient herself or from another patient into the fundus uteri or a Fallopian tube. A piece of ovarian tissue as largo as a pea is excised and kept in warm normal salt solution. The fundus uteri is reached by * Curatulo and Tunilli, La Secrezione Interna delle Ovaie, Home. 1896. ^The results of salpingo-oopliorectoiny have been discussed by Coe, Medical Record, April 19, 1890; bv Jjoldt, ibidem, May 17, 1890; and Lusk, Amer. Jour. Oh.«t., 1891. ^Sherwood-Dunn, Annals of Gynecol., Nov., 1897, Mar., April. 1898, vol. xi. DISEASES OF THE FALLOPIAN TUBES. 571 laparotomy or, preferably, posterior or anterior colpotoray. An incision is made in the median line of the fundus to the cavity. The ovarian graft is inserted in such a way that its epithelial sur- face protrudes into the uterine cavity, and the raw surface is in con- tact with the raw surface in the fundus, where it is fastened by a single stiteh of fine catgut, which also, as well as other sutures, serves to close the incision in the fundus. A gauze drain, inclosed in a rnbber tube, is placed in the uterus against the place of grafting and let out through the vulva. After forty-eight hours it is re- moved. If the tube is chosen, a probe is inserted, the wall cut on this ; and in one point of the circumference the mucous membrane and the peritoneum stitched together, in order to prevent protrusion of the former. Xext the tube is dilated and the graft inserted with the epithelial surface turned into the lumen, and the raw surflice stitched to that of the tube ; and finally the tube is closed by suture over the graft. ^ Like other laparotomies, this operation may cause injury to a ureter, ventral hernia, fecal fistula, an abdominal sinus following the use of a drain, and intestinal obstruction ; or it may aggravate pre-existing diseases in other organs, all of which has to be considered before determining on the operation. B. Vaginal Salpingn-odphorccfoviy presents the advantage that there is less shock and less risk of causing a hernia, but it has the draw- back that the field of operation is so narrow and deep-seated. Now, the frequency of ventral hernia following laparotomy was due to the hasty and imperfect w'ay in which the abdominal wall used to be closed, and can to a great extent be avoided by proper care. On the other hand, the abdominal section offers the immense advantage that if necessary every part of the pelvic cavity can be made visible and accessible, and, taking into consideration how uncertain the diagnosis is in these dee])-seated affections, and how often there are adhesions to the intestine and its appendix, that is a point of ])aramount im])ort- ance. If we enter through the abdominal wall, the incision may bo enlarged, and we are able to coj)e with every arising difficulty, while when entering through the vagina we have to work through a small opening at the bottom of a long tube. Without speculum and retract- ors we do not see anything at all, and if we use them, they block the passage for our fingers. 'J'his method was excellent for the removal of healthv ovaries and at a time when lack of antise|)tic surg<'rv made the opening through the abdominal wall much more dangerous than that thn)Ugh the vagina, but for the needs of tiie present day, when W'e es|K'ciallv wish to i-emove diseased tubes, and witli our ])resent H'sources in regard to heniostasis and drainage, the abdominal method is ])referiibl('. ' KobtTt T. Morrihoii, Lrrture.t an Ajipnulicitis, New York, IS'.ifi, |>. ITjG. 672 DISEASES OF WOMEN. In the vaginal operation the vagina is opened by anterior or pos- terior colpotoniy, or both ; and in order to gain more room an incision in the median line may be carried from the posterior transverse in- cision as far down as tiie bottom of the pouch of Douglas, after which the operator works mostly with liis forefinger, until he can plunge it into the peritoneal cavity. Adhesions are torn and the appendages brought down and ligated, or treated otherwise and re- placed. Hemorrhage is stopped by the same means as when lapa- rotomy is performed, and the wound is closed or left open. (See Hysterectomy for Uterine Fibroids.) If the appendages of both sides are so diseased that they must be removed, much space is gained by first extirpating the uterus by vaginal section. But since it is so much better to leave even only part of an ovary (p. 570), and since this cannot be done if we begin by performing hysterectomy and tear out the appendages in the dark (p. 567), either laparotomy or colpotomy should be pre- ferred to hysterectomy. The situation of the appendages and the shape of the pelvis ought also to have great weight in the choice of method ; if the parts to be removed are situated near or above the brim of the pelvis, or if the pelvic cavity is deep and narrow, the abdominal method may be the only available one. Cystic Salpingitis. When a considerable amount of fluid distends the tube, it forms a cyst. The abdominal ostium is closed, the uterine may yet remain open. The cyst forms a tumor situated to the side of and above the uterus, whence it may extend up into the abdominal cavity or down betweeu the layers of the broad ligaments. The swelling may be club-shaped, with a narrower inner and a wider outer end ; or it may be more globular and be bound to the uterus with a narrow pedicle, corresponding to the inner undilated part of the tube ; or it may be divided by external bands or inner partitions into a series of com- partments, which gives it the appearance of a string of sausages. The contents vary much, but may be divided into three chief classes according to the preponderating element — namely, pus, blood or serum. Often different kinds are found in the same individual. Symptoms. — When salpingitis leads to the formation of a cyst, pres- sure-symptoms are added to those due to inflammation. The patient complains of heaviness and a bearing-down sensation, meteorism, con- stipation, often combined with a frequent desire for defecation and micturition, which is an inconvenience in daytime and disturbs her rest at night. Sometimes there is a constant slight discharge of blood from the uterus. She has pain in the inguinal and sacral regions, and repeated attacks of peritonitis. By bimanual examination a tumor of the description just given is DISEASES OF THE FALLOPIAN TUBES. 573 felt which may be movable or immovable, more frequently the latter. Diagnosis. — The diagnosis between cystic salpingitis and certain other diseases may be difficult or impossible. Tubal pregnancy forms a similar globular tumor fastened to the cornu of the uterus. The history, the presence of signs of pregnancy, the expulsion of shreds of a decidua, and attacks of sudden pain so violent as to make the patient scream and sink down on the floor may, however, enable us to make the diagnosis of tubal pregnancy. An ovarian cyst, be it pedunculated or intraligamentous, may be entirely like cystic salpingitis; but sometimes the ovary may be felt beside the cystic tube, and the history of the case may give useful information. Cysts of the broad ligament are less painful, hardly tender, immov- able, and tip the uterus to the opposite side. A periionitic exudation causes a constant pain, is immovable, and pushes the uterus forward and downward, but all this may also be found in cystic salpingitis. A uterine fibroid may form a similar tumor either in the abdominal cavity or between the layers of the broad ligament, but it is harder, never fluctuating, and the depth of the uterine cavity is increased. A uterine fibro-cyst is in closer connection with the uterus, and the sound reveals an increased depth of the uterine canal. Swollen pelvic glands may give a similar history and form a similar tumor. Aspi- ration may give information about the presence and nature of fluid, but ought not to be used unless the tumor is adherent to the abdomi- nal wall or tiie vaginal vault. Tiie differential diagnosis between the three kinds of cyst may also be very obscure, although certain circumstances may point more dis- tinctly to one rather than to tiie others. Thus pyosalpinx is by far more common, follows gonorrheal or puerperal infection, is very adher- ent and tender, often rauses fever, and is apt to form fistula?. Like iiydrosalpinx it is usually bilateral. Hydrosalj)iiix may form a timior of much larger size. As a rule, it is less adherent and less tender, and causes less constitutional disturbance. Hematosalpinx is cxcccdiiigly rare, is often unilateral, and may be accompanied by a (constant bloody discharge from tiie uterus. Sonie- tinies it is combined with hetnatocolpos and hematonietra. Treatment. — As a rule, the cystic tube with the ovary should be removed. An (-xploratory laparotomy should be performed. If the cyst is large, it is well to empty it with trocar or aspirator, and close the opening with pressure- forceps bef"ore extirj>ating the tumor. If it is small, it may be removed in tofo. Some jirefcr the removal through the vagina, wliich also may begin as an exploratory incision. The arrest (A' /icmorrliagr may l)e very troublesome. It lias become 574 DISEASES OF WOMEN. necessary to leave pressure- forceps in the abdominal cavity till the next (lay, and even to perform hysterectomy, but as a rule the opera- tor will be able to control bleeding by the usual means : tying of arteries, temporary compression with forceps, sponges, or compresses, flushing the abdominal cavity with hot water (p. 186), uniting perito- neal edges with a continuous suture of catgut, stitching other bleeding places in a similar way (p. 526), and permanent comj)ression with iodoform gauze with or without (iounter-pressure in the vagina (p. 185). (Compare Treatment of Intraligamentous Ovarian Cysts.) Broad adhesions are often better separated with a sponge than with the fingers. Band-like adhesions should be tied near both ends and cut away, as their presence later might give rise to intestinal obstruc- tion. If there are many adhesions, the removal of the cyst is some- times facilitated by cutting the tube between two ligatures near the inner end, and proceeding outward instead of going from the infundi- bulopelvic ligament and the pelvic wall toward the uterus. In order to guard against infection it is best to cut the tube with Paquelin's thermo-cautery or sear the ends after having cut with knife or scissors. The prognosis for the operation is better in hydro- and hematosal- pinx than in pyosalpinx. Besides these considerations applying to cystic salpingitis in general, each of the three varieties offers some peculiarities. Pyosalpinx. Pyosalpinx is that form of cystic salpingitis in which the contents are purulent. The name is only used if an appreciable cyst has been formed, while a small amount of pus in the tube simply constitutes purulent salpingitis. The cyst has in most cases the size of a Bartlett pear, but may be as large as a fetal head at term or even a cocoanut. The wall is in general thickened, but has thin places, especially upward and backward, where the cyst is apt to burst during the operation for its removal. The abdominal ostium is closed by agglutination of the fimbriae among themselves or to the ovary. The uterine ostium may yet be open. As a rule, the cyst is adherent 'way down in Douglas's pouch. The uterus is often retro- flexed. The fluid is thick ])us, sometimes of a dirty color and offensive odor, due to the neighborhood of the intestine. In the course of time it may change, blood being admixed with it by hemorrhages from the wall, or it may become inspissated to a putty-like mass, or the cellular elements may be absorbed, leaving a more serous or mucoid fluid. If left alone, the cyst may rupture and discharge its contents into DISEASES OF THE FALLOPIAN TUBES. 575 the peritoneal cavity, causing sudden death, or in between the layers of the broad ligament, whence it may find an outlet through the rectum, the vagina, the bladder, or the skin, either above or below Poupart's ligament, or in the gluteal region. Such rupture often leaves a fistulous tract with no tendency to heal, the continued dis- charge exhausting the patient. Treatment. — If the cyst adheres to the abdominal wall, an incmon should be made parallel to Poupart's ligament, and, if possil)le, a counter-opening made in the vagina, establishing through-drainage with a soft-rubl)er drain. If tiie cyst adheres to Douglas's pouch, the incision may be made in the vagina. If situated higher up, it may still be reached through incision and puncture (p. 562). It may be drained, as stated above (p. 562), irrigated with antiseptic fiuids, injected with tincture of iodine, touched with a stick of nitrate of silver, or painted with iodized phenol (a mixture of iodine 1 part and crystallized carbolic acid 4 parts), but tlie abscess may continue to discharge for many months. Some operators perform kiparotomij either in one sitting or in two acts. By the latter method the sac is made to adhere to the abdomi- nal wall before it is opened. The common way is to operate in one sitting, guard the peritoneal cavity against the entrance of pus by means of large sponges or gauze compresses, and, if it has entered, to wipe it off, drain or pack the pelvis or irrigate the abdominal cavity with plenty of warm normal salt solution and extirpate the sac (p. 567). Boinet found that j)us from an old pyosalpinx does not contain bacteria; and even from recent cases pus containing streptococci may be injected into animals without causing disease. Jiut if these same cocci are cultivated on agar bouillon, they become very virulent; and as raw surfaces left by operations have a similar elfect, he advocates drainage of the ])eritoneal cavity in these cases. ^ Many prefer the rayiudl <:vtirp(iti()V,x\'> a rule, beginning with hys- t(!reetomy. \\\ this method, however, it is often impossible to re- move the cyst. 'J'hen a large incision is made into it, and it is j)acked with iodoform gauze, which acts as a drain, and later may be replaced by a double-current soft-rubber drainage-tube. ILjdroHalpbix. In hydrosalj)inx the fluid is sentus, mucous, or pultaceous. Some- times it contains cholesterine. The wall is, as a rule, thin and trans- lucent. This variety of (ystic; salpingitis is less apt to become adhe- rent and is, therefore, often movable. Like pyosalpinx it is in general bilateral, but it develops more slowly, gives rise to less pain, and » Boinet, Macredi Mcdiml, 1894, No. 47. 576 DISEASES OF WOMEN. may become larger. In most cases it is not larger than a pear, but it sometimes reaches the size of a fetal head at term, and may even form a very large cyst (Fig. 309). Even if only one side is affected Fro. 309. Hydrosalpinx.! the patient is, as a rule, sterile. Often hydrosalpinx is accompanied by a cystic degeneration of the ovary, and through inflammation it may become adherent to an ovarian cyst, which may make an im- pression as if the hydrosalpinx itself were of unusual size. Rupture of the sac is an exceedingly rare event, and the general condition is much better than in pyosalpinx. It is probably the remnant of an old catarrhal or, perhaps, even a purulent salpingitis. The diagnosis might, perhap.s, be made surer by aspirating the fluid, but, being less adherent, iiydrosalpinx is less fit for this operation. We might find ' Specimen from my operation on Mrs. A. N in St. Mark's Hospital, on April 30, 1892. In this case a unilateral hydrosalpinx formed a tumor filling the pelvis and reaching to the level of the umbilicus. DISEASES OF THE FALLOPIAN TUBES 577 ciliated columnar epithelium in the fluid, but that may also be found in certain ovarian cysts. Treatment. — A small cyst of this kind may give so little trouble that it may be left alone. Sometimes aspiration through the vagina may effect a cure. The tumor may be emptied by means of an incis- ion made in the vagina and drained, but this process may prove a tedious one. In most cases laparotomy is performed and the tumor is removed. If the tumor is not very large, and the ovaries are in a fair condition, an attempt may be made to save one or both sets of append- ages (p. 663). Hematosalpinx. Hematosalpinx is the name of a cyst formed by the tube and filled with blood. There are two forms : in one the blood is not coagulated, but kept fluid by admixture with alkaline secretion from the inside of the tube; in the other is found a laminated fibrinous clot due to successive hemorrhages. In the former the wall need not undergo much change, and the blood may be reabsorbed ; in the latter the wall is much thickened. The effused blood may be inspissated to a syrupy mass or changed to pus, and the wall may ulcerate and finally rupture, an accident which is nmch more common with hematosalpinx than with hydrosalpinx, and has to be guarded against in operating for atresia of the genital canal (p. 347). Etiolocjy. — Exanthematous and infectious diseases, phosphorus-poi- soning, extensive burns, and diseases of the heart, lungs, and kidneys, may cause ecchymosis or sligiit hemorrhage into the tubes. In pyosalpinXjhemorrliage may take place from the wall, and blood mix with the pus. Wlien there is an occlusion of the genital canal, the menstrual blood which normally is secreted in the tubes (p. 118) is retained and forms hematosiUpinx coml)ined with hemato<"()lpos and hematometra, al- though the comnnuiication between the tube and the uterus may be interrupted (p. 345). Hematosalpinx may also be due to a uterine fibroid or an inflamed ovary, causing salpingitis by extension of the inflammation of the endo- metrium or the ovary and closing the tube, or it may be a reflex eflect of an extra-uterine |)regnancy in the other tube. The most common cause of hematosalpinx is, however, extra-uterine pregnancy in the same tube. Ircatmnif. — Small tumors need no treatment. In that lorni which contains fluid bloml, laparotomy or colpotomy may be performed, the tube; cleaned out, made perviabh;, and allowed to remain (]>. 563). If the cystic tui)e has deveio|M'd down between the layers of the l)road ligament, which may be supposed when it is low down and immovable, an incision may be made in the vaginal vault and the cyst drained. 578 DISEASES OF WOMEN. Large tumors filled with clots or blood mixed with pus should be removed by laparotomy. The same procedure becomes necessary after the operation for atresia of the genital canal, if it has not pre- ceded it (p. 347). Hematosalpinx due to ectopic gestation is treated by extirpation of the tube in which the ovum is developed through either an abdominal or a vajjinal section. CHAPTER HI. Displacements. The tube may be found in a crural or inguinal hernia, and is then generally accompanied by the ovary. In the higher degrees of invereion of the uterus the tubes are always drawn into the sac formed by the inverted uterus (p. 487). CHAPTER IV. Neoplasms. The neoplasms of the tubes are not of much practical interest, as they often cannot be diagnosticated, are so small that they do no harm, or appear together with affections of greater importance in the neigh- boring organs. A. Ci/sts. — Real cysts, which are something entirely different from cystic salpingitis (p. 572), may be found in all three layers composing the wall of the tube. They range in size from a millet-seed to a wal- nut, and contain a citrine, serous fluid. They are seen very frequently in laparotomies and autopsies. One of them situated at the ab- dominal end of the tube is so common that it is described in works on normal anatomy under the name of the hydatid of Morgagni. It is a development of the up])er end of the Miillerian duct (p. 30). Some of these cysts are doubtless remnants of the Wolffian body (p. 20), and others are the result of extravasations of blood. ^ The fluid contained in them is so bland that, even if through a rupture in the wall it should find its way into the peritoneum, it could hardly do any harm. B. Fibroma. — ^Myomatous and fibrous tumors like those of the uterus (p. 49.3) are formed in the muscular coat, but do not, as a rule, acquire surgical dimensions. One case, however, has been reported in which the growth reached the size of a fetal head at term. ' This was so in a ca.se of chronic oophoritis and salpingitis operated on by me and exaniiiud niiscroscopically by Charles Heitztnann. DISEASES OF THE FALLOPIAN TUBES. 579 C. Lipoma. — Fatty tumors of the size of a bean to that of a wal- nut have been found at the lower side. D. Papilloma, a real neoplasm, must not be confounded with the growth of the raucous membrane due to simple hyperplasia and hypertrophy accompanying salpingitis (p. 55-1), nor with malignant growths, all new growths of the Fallopian tubes having a tendency to assume the papillary appearance. True papillomata of the Fal- lopian tube are rare, only seven cases having been reported.^ Cysts are formed either by fusion of the papillomatous excrescences or in the wall of the mother cyst. Papillomatous tumors may close, dilate, and even rupture the tube, in which latter case a papillomatous in- fection would be likely to take place in the peritoneum. They are commonly small, but may reach the size of a child's head. E. Cancer, either carcinoma or sarcoma, may occur primarily in the tubes, but is nearly always secondary to cancer of the uterus or the ovary. The disease makes its appearance about the time of the menopause, and develops slowly. It gives rise to a sanious discharge from the vagina, which, in connection with the presence of a tumor and the absence of signs of uterine or vaginal cancer, may lead to a diagnosis. As a rule, it is not recognized before an autopsy is made. If it can be diagnosticated in life, the tube and ovary should be removed by laparotomy. F. Tuberculosis. — The Fallopian tube is more apt than any other part of the genital apparatus to be the seat of tuberculosis. In fact the tubes are affected in nearly all cases of tuberculosis of the genital tract, and genital tuberculosis is much more common than was for- merly surmised. It may be primary in this locality, and is then probably due to infection through the semen of a tuberculous man. Much more fre- quently, however, it is secondary, following tubercular peritonitis or being the eti'ect of infection through the blood in persons sulfei'ing from phthisis. As a rule, both tubes are affected. The wall is swollen, its epitiielium is thrown off, the ostia are generally closed, the caliber is enlarged, and the tube is filled with a caseous mass. The microscope reveals the characteristic formation of tubercles in the wall — nuclei centering around giant cells — and the presence of Koch's bacillus in the tissue and in tlie secretion. Often the peritoneum in the vicinity is studded with miliary tubercles. Jn advanced cases the whole nuicous membrane is destroyed. Tiie tubes are in general out of place, often drawn down along the edges of the uterus, and bound to neighboring parts by adhesions. They may form tumors as larg<' as a goose-egg, the shape of which is that of a sausage, a club, or most frequently a string of 3 to o beads, the 'J. G. Clark, Johns Hopkins Hospital Bidldin, July, 1898, No. 88. 580 DISEASES OF WOMEN. single knobs of which are round or oval and hard, while in pyosal- pinx they are soft. Another point of difference between the two is that in pyosalpinx the part of the tube situated near the uterus is nearly always free, while in tuberculo.sis the disease affects this part and even the intramural portion as well. Sometimes tubes, ovaries, and uterus are all matted together by exudation into one large mass. The disease is very rarely acute; in general it has a chronic course. The si/mpto7ns are like those of salpingitis. The diagnosis is often obscure ; but occasionally it may be made by reference to hereditary predisposition ; by finding signs of tuberculosis in other parts, especially the lungs ; by finding caseous masses and bacilli in the vaginal secretion ; and by the peculiarities of the tumor just mentioned. Treatment. — As a prophylaxis connection with a man affected with tuberculosis should be avoided. The hygienic and medical treatment is the same as for tuberculosis in general. If the general condition of the patient is not too bad, salpingo-oophorectomy may perhaps effect a cure; but on account of the adhesions the operation is often difficult and sometimes impossible. If the uterus participates in the degeneration, this may be removed together with the tubes and ovaries. But as it is uncertain if all affected tissue has been removed, and as the operation itself by rupture of the tube and entrance of its contents into the peritoneal cavity may spread the infection, the treat- ment, upon the whole, is unsatisfactory. The presence of tubercular peritonitis or a mild degree of phthisis is no contraindication for the operation.^ ^ An exhaustive monograph by J. AV. Williams on "Tuberculosis of the Female Generative Organs" is published in Johns Hopkins Hospital Report in Pathology, ii., Baltimore, 1S92, pp. 85-144. PART VL DISEASES OF THE OVAEIES. CHAPTER I. Malformations. Excessive Growth. — The ovaries of new-born children may have twice the normal size, which may either be due to a uniform hyper- plasia of all the constituent parts, or, more frequently, to fetal inflam- mation, resulting in a preponderance of connective tissue and a partial or total disappearance of tlie Graafian follicles, Supernumerari/ Ovaries. — Small globular, pedunculated bodies of the same structure as the normal ovaries, and varying in size from that of a pea to that of a hazelnut, are found in 5 per cent, of all bodies of women. These small ovaries are situated near the peri- toneal border of the normal ovaries. An ovary may be more or less completely divided into two parts by fissures. In a unicpie case there were even found three large ovaries, eacii bound to tiie uterus with a separate ligament. The possil)ility of supernumerary ovaries must be kept in mind in order to explain the persistence of menstruation after the extir- pation of both ovaries (j)p. 121 and 569), the presence of two nor- mal ovaries l)esides an ovarian cyst, and the occurrence of pregnancy after double ovariotomy — phenomena which have actually been observed.' Absence or liudimentavy Development. — Both ovaries may be absent, a condition which usually is combined with absence of the uterus. One ovary may be absent in cases of uterus unieornis. More common than the total absence is a rudimentary develo])ment of the ovary. Such rudimentary ovaries may or may not contain Graafian fi)llicles. In the latter case they consist only of connective tissue and smooth muscl(!-fi bet's. As a rule, the rudimentary condition is found in connection with an arrest of development of the uterus, but it may also be foiuid when ' F'or details st>e my article on " Mallonnations of the I'Vinak' (Jiiiitals," in Atiwr. System of Gifnecoloyy, edited by Mann, vol. i. p. 23G. 5HI 582 DISEASES OF WOMEN. the uterus is normal. Women without Graafian follicles do not men- struate, and are sterile, but may have sexual desire and a perfect female Rudimentary ovaries are often found together with an imperfect development of the large blood-vessels, especially the aorta, or of the central nervous system, especially in idiots and cretins. CHAPTER II. Foreign Bodies. In rare cases a needle has been found in the ovary. A sewing- needle may enter the ovary after wandering a more or less long dis- tance through the soft tissues of the body, or more directly from the intestine.^ A darning-needle, found partially in the uterus and partially in the ovary, had probably been introduced through the OS with the intention of producing abortion.^ The foreign body causes pain and inflammation, and should be re- moved. If part of the body is situated in the uterus, it will prob- ably be possible to reach it by dilatation, and withdraw it. If it is all imbedded in the ovary, anterior colpotomy or laparotomy will probably allow one to remove it by cutting down upon it and to sew the ovary up again ; but if it has formed an abscess, it may be necessary to remove the ovary. CHAPTER III. Displacements. One or both ovaries may occupy an abnormal position. In its unusual place the ovary may have preserved its normal connections, or it may have been cut oflp altogether from the broad ligament by an inflammatory process in fetal lite. It may then either float about as a small hard body in the abdominal cavity or it may become fastenal to the lower border of the omentum. If the displaced ovary retains its normal connections w'ith the ala vespertilionis and the tube, it may be found outside the pelvis or remain in it. Extrapehic Displacements. — It may be found in the lumbar region, or, passing through the same openings as other hernise, it may occupy the inguinal canal or the labium majus {inguinal hernia) ; the ante- 1 Frank W. Haviland, New York Med. Record, Oct. 2, 1892, vol. xlii. p. 398. 'C. Liebmann, Cenlraibl. f. Gyndk., 1897, vol. xxi. No. 16, p. 421. DISEASES OF THE OVARIES. 583 rior side of the thigh below Poupart's ligament (a-ural hei-nia) ; the gluteal region [gluteal hernia) ; the depth of the anterior wall of the pelvns (obturator hernia), or the anterior surface of the abdomen (ventral hernia). The position of the ovary in the lumbar region is very rare. It is due to a lack of descent (p. 23), and is only found together with a considerable arrest of development in other respects. Inguinal hernia of the ovary may be congenital or acquired. The congenital may be due to a deficient development of the round liga- ment, by which the ovary, tube, and sometimes one horn of a uterus bicornis and part of the omentum are pulled through the canal of Nuck. More rarely the ovary alone is found in a congenital inguinal her- nia, into which it easily drops during intra-uterine life on account of being much smaller than the caliber of the canal of Nuck. The acquired form can only occur if the tube and the infundi- bulopelvic ligament are unusually elongated and lax, and may. then be produced by a fall or similar violence. In its abnormal place the ovary may become inflamed or undergo cystic or cancerous degeneration. Congenital inguinal hernia cannot be replaced. It may be pro- tected by a hollow pad or, if it gives trouble, it may be extirpated. The acquired form may be brought back through the canal and kept back by means of a truss or the radical operation for hernia. If it cannot pass the canal, herniotomy shoidd be performed. If the ovary is seriously diseased, it should be extirpated. Crural ovarian hernia is always acquired. If the ovary cannot be replaced by taxis, herniotomy should be performed, after which a truss should be applied. It should only be removed, if it is so seri- ously affected that medical and palliative treatment must be without avail. The other hernine througii natural openings are exceedingly rare. The ovary may he found in a ventral hernia after laj)ar()tomy, and would offer a special intlication for operating on the hernia. The ovaries may also be drawn with the tubes into the funnel of an inverted uterus (p. 487). Intrapelric DiKplacnncnta. — While the preceding displacements are anatomical or surgical curiosities, the infraprlrir <li-y)lacanenf, or prolap.^e, of the ovarij is a common disease of considerable practical importance.' The normal ovaries may frecpiently be palpated in their normal situation by bimanual vagino-abdominal examination. Thev mav likewise be felt by recto-abdominal (examination, but the latter ' This disease lias lu'en treated of in an exhaustive way hy P. 1'. Mund<^, 7V((n,<t. Avirr. (iijn. Sor., 1871*, vol. iv. p. 1G4 el ne<j. 584 DISEASES OF WOMEN. offers no advantage, except in intact virgins or women with atresia of the vagina, unless the uterus is pulled down at the same time (p. 143). When the ovary becomes displaced it sinks backward, downward, and inward, describing an arc with the ligament of the ovary as a radius and its insertion on the uterus as a center. Thus it sinks first down on the retro-ovarian shelf (p. 94), and next into Doug- las's pouch, and may sink as low down as the level of the os uteri. Etiology. — The left ovary is much more frequently prolapsed than the right, the cause of which is probably to be sought chiefly in the absence of a valve in tiie ovarian vein on this side, and its opening into the renal vein under a right angle — circumstances that favor passive hyperemia in the gland and predispose to disease (p. 77). The presence of the rectum on the left side and the motion of hard fecal lumps downward help also to dislodge the ovary. The mere increase in weight of the ovary is sufficient to cause it to prolapse, as is proved by cases in which, after the subsidence of swelling, the organ returns to its normal place. It may be pushed out of place by tumors or drawn down by a retro verted or retro- flexed uterus or by adhesions remaining after ])elvic peritonitis. It may also sink on account of insufficient support from below, espe- cially rupture of the vaginal entrance (p. 322). Prolonged sexual irritation may cause the prolapse by producing hyperemia. Pregnancy offers particularly favorable circumstances for the pro- duction of prolapse, since the ovaries are enlarged and ascend into the abdomen, and their attachments become softened and elongated. Inflammation and beginning cystic degeneration increase the weight, and are often the cause of adhesions. AA hether a normal ovary can become prolapsed by a fall or similar injury, as is the case with the uterus (p. 478), is doubtful, but if it is enlarged beforehand, such a traumatic impulse is enough to cause the displacement. Prolapse of the ovary is frequently associated with acquired ante- flexion of the uterus, the cause of both troubles being probably sub- involution after pregnancy and the concomitant lack of tonus in the tissues. It is also often combined ^\•ith tubal disease. Symptoms. — The symptoms are those of chronic oophoritis com- bined with those due to the abnormal position of the ovary. Plypere- mia, edema, and inflannnation may be both the cause and the effect of the displacement. The patient com])lains of pain in the sides of the pelvis, the sacral region, or the rectum, often shooting down to the knee and up into the hi]). The pain gets worse when she walks, pre- DISEASES OF THE OVARIES 585 vents her from standing for any length of time, and is sometimes aggravated by sitting down. It is also increased very much by pal- pation, and may continue through the whole day u])ou which the ex- amination has been made. This great tenderness also renders coition painful or impossible, and causes great pain during the passage of hard fecal masses, and often painful tenesmus after they have been expelled. Menstruation is, as a rule, painful and often too profuse. Nausea and vomiting are not rare. The whole nervous system suifers much. The })atient is tired, des])ondent, and irritable. Some- times she may even have attacks of epilepsy. Diagnosis. — The diagnosis is, as a rule, easily made by bimanual examination, when the ovary is recognized by its shape, its connection with the uterus, its great sensitiveness if it is inflamed, or at least a sickening feeling on pressure if it is normal. If the ovary is situated on the retro-ovarian shelf, it is felt best by examining the patient in the left-side position and pressing the perineum well back. The swollen tube has a more sausage-like slia})e. A small pedun- culated fibroid of the uterus is harder and not sensitive. Remnants of pelvic inflammation are more diffuse and less tender. Sci/bala are less tender, may often be indented or crushed, and may be removed by enemas and aperient medicines. Prognosis. — The displaced ovary is liable to become inflamed or cystic. If it is movable, the prognosis is comi)aratively good ; but if it is bound in its new position by adhesions, the treatment will at best be a very protracted one, and a cure is doubtful. Treatment. — The two chief indications are to combat hyperemia and inflammation and to replace and retain the ovary in its normal place. The first is aimed at by rest, keeping the bowels open (p. 241), prohil>iting sexual connection, prescribing hot vaginal douches (p. 170), using scarifiation of the cervical portion (p. 15)4), making a])plications of iodine (p. 17")), or inserting j)ledgets with iehthyol- glycerin (p. 182) into the vagina, or by means of galvanism with the positive pole in tlu; vagina (j). 248). Tile displaced organ should be rej)laced as soon as feasible, but sometimes the above-mentioned measures must be taken lirst befon* the ovary recovers sullieiciitly to l)e able to bear the pressure (»!" a pessary. The ovary is best rej)laeed in the genu-pectoral posture (j). 1 10), and if it <'anuot b<' I'eplaeed or retained at once, the dailv us(> of this ])osture and a glass tube admitting the air into the \agina (p. 17<>) may j)repare the way for its final replaeemetu. I f the ovary is adherent, it is necessary first to trv to bring about the stretching and absorption of" the adhesions. This is douc liy packing the vagina (p. 182 1. If" the o\ary is \-ery tender at lii'st, 58G DISEASES OF WOMEN. perhaps only a single cotton ball will be tolerated, but gradually more are put in, so as to lift the ovary up in the pelvis. Massage (p. 199) is also a powerful means of stretching and break- ing up adhesions. The gtilvanic current has, in consequence of its electrolytic property (p. 248), a similar effect. Schultze's method is somewhat similar to that used by the same author for uterine adhesions (]). 473). The forefinger is introduced into the rectum of the anesthetized patient in the lithotomy position, and bored in between the ovary and its surroundings, while the uterus is grasped with the other hand through the abdominal wall and pulled upward. The retention of the ovary in its normal position is often more difficult than its replacement. Sometimes Thomas's hard-rubber bulh-peKsai'i/, essentially a Hodge pessary (Fig. 274, p. 469) with a thickened upper arch, answers a good purpose. Special pessaries of hard rubber with a cross-bar of unusual width, or with a notch in the middle or a corner cut off, have been constructed for this condition.^ In cases in which no hard pessary can be tolerated, one of whale- bone covered with soft rubber (p. 470) may be tried. If these measures fail, we may have recourse to cutting operations. If the uterus is retroverted or retroflxed, it may be brought forward by shortening the round ligaments (p. 471), suspensio uteri (p. 474), or fastening of the round ligament to the abdominal wall or the vagina (p. 475). If the uterus is not displaced, but the ovarian displacement is due to an elongation of the infundibulopelvic ligament, that may be shortened by taking a reef in it (p. 577). The ovary may also be sutured directly to the peritoneum of the pelvis. But if the ovary, besides being prolapsed, is diseased, the pr()])cr thing to do is to ])erform salpingo-oophorectomy, especially by vaginal section (p. 576j. CHAPTER IV. Hyperemia and Hematoma. A normal hyperemia doubtless takes place in the ovary during coition in consequence of contraction of the uiistriped muscle-fibers of the broad ligament (p. 57), and contributes to the expulsion of the ovum (p. 77). A similar normal hyperemia probably returns at regular intervals, corresponding to menstruation. At least the gen- ' See the above-mentioned article by Munde. DISEASES OF THE OVARIES. 587 eral blood-pressure of the whole system is increased before menstrua- tion sets in (p. 117), and in some women a very considerable increase in size may be found alternately in one ovary or the other at the menstrual periods (p. 120). An effusion of blood also takes place normally into the ruptured follicle after the expulsion of the ovum (p. 75). Pathological Anatomy. — Abnormal hemorrhage may take place into the Graafian follicles or into the stroma of the ovary, the fol- FiG. 310. Hematoma of Ovary (a little less than natural size): a, follicular hematoma, 12 millimeters in diameter, inner measure ; fresh bloo<lclot easily separated from tlie surrounding wall, situated in the outer end of the ovary, one-half of it touching tlie stroma, the other half covered with a layer varying from 2 to 3 millimeters in thickness, without any opening; 66, dilated follicles with serous contents ; c, Fallopian tube.' licular being much nioic coininoii than tiic stromal. Follicular hem- orrhage forms a tumor that is rarely larger than a hazelnut (Fig. 310), but may reach the size oi" a wahiut. Tlie ovary is only moderately eularg-ed and a little nK)re resistant. If manv follicles are filled with blood at the .same time, it is dark and studded all over the suriiice with small ])rotul)erances. The sac is thinned on the side nearest the surface. The contents ai'c dark, thin l)lood mixed with clots. In the course of time it may change into ' Loft ovary from my Haliiinf^o-fMiphnrectomy on Mrs. 1* in St. Mark's Ilospitiil, Nov. 29, 1892. Tlie rij^ht ovary contained a serous cyst ineasuriiiL,' 2 cm. in diameter. 688 DISEASES OF WOMEN. a thick chocolate-colored fluid, M-hicli may l)e of the consistency of honey. Tlie fluid part may be absorbed altog;ether, leaving a granular pigment; or the solid parts may be absorbed, so that only a cyst filled with serous fluid remains; or suppuration may set in. As a rule, the follicle does not bui-st, but tiie ovum is destroyed. Stromal hemorrhage may cause so small an extravasation of blood that it can only be seen Avith the microscope, but it may impart a red- dish color to the ovary, and even show as minute red points on the cut surface. On the other hand, it may gradually, by repeated new escapes of blood, destroy the whole tissue of the ovary, and form a hematoma as large as a man's fist or a child's head. In other cases the tissue is preserved, but so infiltrated with blood that the whole ovary is like a sponge soaked in blood. Such enlarged ovaries are bound by adhes- ions to the neighboring organs. The stromal hemorrhage may be primary or follow as a secondary event after follicular apoplexy. Any extensive hemorrhage may cause rupture of the ovary, the blood pouring into the peritoneal cavity or penetrating between the two layers of the broad ligament. The extravasated blood under- goes changes similar to those just described for the follicular form. Etiology. — Hyperemia and hematoma of the ovary may be due to any thing that causes venous stasis, such as masturbation or venereal excesses, heart disease, pulmonary phthisis, cerebral apoplexy, tumors, adhesions compressing the veins, or torsion of the ala vespertilionis. Secondly, they may be referable to dissolution of the blood, such as occui*s in severe burns, phosphorus-poisoning, typhoid fever, })uer- peral septicemia, scurvy, etc. Thirdly, hematoma may be developed from gyroma,^ which is the same as corpus albicans (p. 77), and may be the terminal stage of a corpus luteum, or under influence of chronic oophoritis may represent the first stage of an endothelioma, an abnormal formation, which will be described under Oophoritis. Gyroma may occasionally lead to tlie formation of a hematoma, and endothelioma does so quite frequently. Symptoms. — A patient affected with hyperemia of the ovary is liable to suffer from menorrhagia. At the time of menstruation she is seized with sudden pain in the region of the ovaries, extending down the thighs, and sometimes accompanied by neuralgia of the breasts. She has no fever. Hemorrhage in the ovary may take place without giving rise to symptoms. If the collection is large, it causes pain, nausea, vom- iting, and the ovary is felt to be enlarged. If rupture occurs, the ^ This subject was first treated In- Dr. Mary Dixon Jones, and later bv Dr. Francis Foerster and Dr. II. J. Doldt, all workinjj nnder the egis of Dr. C. Heitzmann: Jones, X Y. M>(1. Jour., Sept. 28, 1889. May 10-17, 1890; Timea and Jifrpster, .Apr. 80, 1892; P^oerster, AmiT. Jour. Obst., May, 1892, vol. xxv. p. 577 ; Boldt, International Med. Congresx, Berlin, 1890, and Deutsche med. Wochenschr., 1890. DISEASES OF THE OVARIES. 589 usual symptoms of internal hemorrhage are present, such as shock, pallor, abdominal pain, a cold clammy skin, and a weak, rapid pulse. If a large hematocele is formed, a fluctuating swelling can be felt through the abdominal wall and the vagina. Diagnosis. — Hyperemia or apoplexy may be diagnosticated, if in a healthy person one or both ovaries suddenly become enlarged and tender without fever. In a patient affected with blood-dissolution the apoplexy may be inferred, if she suddenly is seized with ovarian pain, and a movable tumor can be felt in the pelvis. A periodical increase of suffering at the time of menstruation in a person with diseased ovaries is a sign of congestion. The sudden appearance of the signs of internal hemorrhage in such a person denotes that rupture of the ovary has taken place. An extravasation of blood into the broad ligament does not extend so high up as the tumor formed by intraperitoneal hemorrhage; indeed, it often forms a tumor at the base of the broad ligament. A swollen Fallopian tube often is more sausage-shaped, whereas the ovary is more round. Sometimes an aspirating needle may be thrust in through the vagi- nal roof, and the bloody fluid will then help to establish a diagnosis. Prognosis. — Hyperemia can, as a rule, be cured. Hematoma may also be absorbed, but occasionally a rupture occurs, which may end fatally. If due to endothelioma, the whole constitution suffers, and grave nervous symptoms are developed. The normal ovarian tissue disappears gradually, and the ova are destroyed. Treatment. — In hyperemia, rest, inclusive of physiological rest — that is to say, abstinence from sexual excitement — is of great imj)ort- ance. The general health should be improved by means of hygienic measures and tonics (p. 241). The nervous system may be quieted by the use of bromides. A derivation to the skin by means of blis- t<irs may bo useful. The bowels should he kept open. Scarification of the vaginal portion ([). 194) may give great relief In girls of ardent temperament or with l)ad habits marriage may answer a good purpose. The usual treatment for jx-lvic inflammation, such as the use of hot douches, painting with tincture of iodine, tampons with i(!litliyol-glycerin or plain glycerin, or the galvanic current, should be instituted. If then; is an acut(! atta(d<, tlie patient should stay in l)ed, have an i(;e-bag on the hypogastric region, and be given mor- j)liine enough to combat pain. If th(! ovaries have suffered much in their stru(;ture, it may even become necessary to remove them. When symj)toms of ru|)ture are present, laparotomy shotdd be per- formed at once, and the ovary from which the hemorrhage comes should b(! extirj)ated together with its tube. The other ovary should be left, if it is not seriously diseased. 590 DISEASES OF WOMEN. In a case operated on by the w ritor the hematoma was due to a solid, imperforate uterus and atresia of tlie u})permost part of the vagina. The left ovary was transformed into a sac larger than a fist, and filled the pelvic cavity behind the uterus. It was uniformly adherent all over to the intestines and the pelvic organs, and con- tained eight or ten ounces of inspissated chocolate-colored blood. The left tube was the site of interstitial salpingitis ; the right tube Fig. 311. Large hematoma of left ovary : a, imperforate uterus with cervix ; b, right ovary with ruptured Graafian follicle; e, right Fallopian tube with part of broad ligament ; d, left Fal- lopian tube swollen ; e, serous cvst ; /, left ovarv transformed into sac filled with inspissated blood.i and ovary were normal, the latter showing a ruptured Graafian follicle the size of a hickory-nut (Fig. 311). The patient had been suffering for four years from severe molimina, preceded and often followed by epileptic fits. CHAPTER V. Oophoritis. OoPHOEiTis, the inflammation of the ovary, may be acute or chronic. 'Specimen from my abdominal hvsterectoinv on Miss M. B., at .St. Mark's Hos- pital, Oct. 25, 1899. DISEASES OF THE OVARIES. 591 A. Acute Oophoritis and Ovarian Abscess. The inflammation may begin on the surface, — perioophoritis, — which is identical with local peritonitis (although the ovary has no perito- neal covering, p. 69), in the follicles, — -follicular oophoritis, — or in the stroma, — interfollicular oophoritis, — -just as we have seen in regard to hemorrhage, with which it is in many cases connected in such a way that it is difficult to say which hais preceded the other. The distinctive anatomical feature is here, as in the inflammation of other parts of the body, the infiltration of the tissue with small round cells, and, if suppuration supervenes, the presence of pns-corpuscles. To the naked eye the condition is in the beginning much like hyperemia ; the ovary is enlarged and impregnated with a reddish fluid ; later yellow points and streaks aj^pear ; and finally these melt together, and an abscess is formed. Of these there may be one or more. In» puerperal and gonorrheal cases usually both sides are affected ; in others, as a rule, only one ovary is inflamed. Before pus is formed the inflammation may end in resolution, but the ovary rarely returns completely to its pristine condition. As a rule, it remains enlarged by formation of new connective tissue or becomes smaller by subsequent cicatricial retraction — cirrhosis. The ovum and the epithelium of the follicles undergo fatty degen- eration. Sometimes the follicles are transformed into small cysts with thickened walls; or they are destroyed, leaving a cicatrix. An abscess may destroy the whole ovary. xVs a rule, })lastic lymph is thrown out as a superficial (;overing over the abscess In the depth of the ovary, and thus the organism is protected ; but rupture may take place into the peritoneal cavity and cause general j)eritonitis. The pus in an ovarian al)scess may be " laudable " or have an off^en- sive odor due to absorj)tion of gas from the rectum. It may become insj)issated, and finally form an innocuous calcareous mass. The niajority of abs(;esses of the ovary arc the work of staphylococci. A few contain bacillus coli communis, and a few otluT ])yogcnic bac- teria have been found in ovarian abscesses. In three cases Kth- ridge found the pneumococcus to be the sole bacterium pn^sent.* The coccus may rea<'h the ovary from the external g<'nitals, from the intestine — where it ai>oun(ls — or through the general circulation. J'Jtiolof/i/. — Extensive cx'iphoritis is a rare disease outside of the puer|x,'ral state. It may be jirinuiri/ or sccondarj). The primary may be caused by hyperemia and hematoma of the ovary (p. oHO), by sexual excesses, or by sudden su})j)ression of tiie menstrual flow (pp. 128, 256). It may also appear as part of a constitutional dis- ease, sucli as the eruptive levers, cholei-a, sej)ticemia — whether puer- peral or not — and poisoning with phosphorus or arsenic. It may ' .1. H. Kthridge of (.'liicago, Amcr. Jour. Med. Sci., April, 18'J(J. 592 DISEASES OF WOMEN. follow minor operations, such as the use of the sound, the incision of the cervix, trachelorrliaphy, etc. The common course is that the inflammation fii-st attacks the endometrium, then the tubes, and finally extends to the ovary ; but it may also reach the ovaries directly through the lymphatics. Secondary oophoritis may also follow after peritonitis, and most frequently it is due to gonorrheal infection, which latter works its way up from the vagina through the uterus and tubes. Si/nij)toms. — In most cases the symptoms are obscured by those of the accompanying disease, especially salpingitis or peritonitis. But sometimes it is possible to feel tlie ovary to be enlarged. It is the seat of a burning pain, radiating down to the knee, to the bladder, and the rectum, and it is exceedingly tender to the touch. The knee on the aflPected side is sometimes drawn up ; occasionally there is a reflex pain in the breast, and nearly always nausea. Like orchitis in the male, oophoritis may alternate with mumps. An ovarian abscess gives rise to recurrent attacks of chills and fever. Sometimes the swollen ovary can be felt, and perhaps even fluctuation can be made out. The abscess may open into the peritoneal cavity, the intestine, especially the sigmoid flexure, the bladder, less fre- quently into the vagina, and rarely even through the abdominal wail. Diagnosis. — It is seldom possible to make an entirely sure diag- nosis. This can only be done if we feel the enlarged and tender ovary. In a suppurating ovarian cyst the symptoms are less acute. Salpingitis and pyosalpinx are sausage-shaped, the inflamed ovary and ovarian abscess globular. Pelvic abscess is situated lower down and absolutely immovable, while the ovarian abscess may be more or less movable. Prognosis. — Tlie prognosis in the common non-septic, acute oopho- ritis is, upon the whole, favorable as to life, even if the disease rarely ends in complete resolution. The inflammation may subside in four or five days. The septic form is apt to form an abscess, and it is not rare that the abscess bursts into the abdominal cavity and causes death from septic peritonitis. If the abscess opens into the gut, the opening may close speedil^v, but sometimes a fistulous communication remains, which may give rise to exhausting fever. Since we have seen that the ova are liable to degenerate, we can understand that oophoritis often leads to sterility. One attack is frequently followed by others, so-called chronic oophoritis. Treatment. — The patient must be kept quiet in bed. An ice-bag is applied over the affected part (p. 195). The bowels should be kept open witii saline aperients (p. 241). Pain is to be combated with opi- ates, preferably hypodermic injections of morphine. If the symptoms indicate the presence of an abscess, the ovary should be removed, either by abdominal or vaginal section. Even DISEASES OF THE OVARIES. 593 if the ovary is adherent, the adhesions are recent and can in all likelihood be separated. If the ovary is within easy reach it is, however, better to make a transverse incision behind the cervix, separate the tissues bluntly, plunge the expanding perforator (Fig. 177, p. 199) into the abscess, dilate, as recommended for py ©salpinx (p. 533), and drain from the vagina. B. Chronic Oophoritis. By chronic oophoritis is understood a chronic condition charac- terized by the remains of acute inflammation of and in contact with the ovary, congestion, and repeated attacks of acute inflam- mation. Pathological Anatomy. — In most cases the ovary is enlarged to two or three times its normal size, and has an ov'al or globular shape. In others it is smaller than normal, forming an irregular shrivelal mass. Very frequently it is more or less cystic (Fig. 312). The Fig. 312. Chronic Oophoritis : a, cut siirfaro of ovary sttiddod with cysts ; b, tube ; <*, pedunculated cyst hiinniiit,' from tlic nicsof^iilpiiix.' capillaries increase in size from the poripliery toward the center, form- ing a structure like that of erectile bodies. The ana-^tomosis between the ovarian and the uterine artery is dihited, whicli may explain the endometritis so often found combined with ehronie ()Oi)horitis. The ovisacs and the ova are often diseased or disappear. First medullary corpuscles are developed, and the yolk and the genninative vesicle ' Specinicn from my salpingo-oophorectoniy on Mrs. ('. C , in St. Mark's IIos- piUiI, on .June 9, IS'JI. .■J8 594 DISEASES OF WOMEN. Fig. 313. y Chronic Oophoritis (natural size) : a, cor- pus luteum changed into cyst ; 6,6, yel- low masses with remnant of central cavity ; c,c, corpora nigra : d, albuginea. break dovvu, leaving a granular mass ; later fibrous connective tissue replaces the whole structure. Sometimes the ovum undergoes colloid or waxy degeneration. The follicles may be transtbrnied into cysts with a thickened wall and surrounded by indurated tissue. The albuginea is thickened, and often covered with an adhesive layer of peritonic origin. A single cyst may reach the size of an English walnut, and cause the absorption of the rest of the organ, so that the ovary is changed to an ovarian cyst. The fluid is se- rous and yellowish, or may by admix- ture of blood become thick and brown. The stroma of the ovary is harder, of a white color, and shows hyperplasia of fibrous connective tissue. The hyperplastic ovary is generally free ; the atrophic, on the contrary, im- bedded in adhesions, to the pressure of which its dwindling probably is due. The formation of cysts is probably caused by congestion at the men- strual period, if the blood-pressure is insufficient to rupture the fol- licle or the rupture is prevented by the thickening of the albuginea, ])erioophoritic adhesions, or the too deep situation of the follicle in the stroma. Sometimes it can be seen that the cyst has formed in a corpus luteum (Fig. 313).^ Etiology. — Chronic oophoritis is by far more common than acute. Often the acute inflammation forms the starting-point, and the reader is, therefore, referred to what has been said above (p. 592) in regard to the causes of that affection. The disease is found most commonly in young women between twenty and thirty years of age. The left side is oftener affected than the right for the same reasons that we have given for the greater frequency of prolapse on this side (p. 584). A misplaced ovary is indeed more liable to the development of chronic oophoritis than one in its normal situation. For the same reason retroflexion ^ Besides the large corpus Inteiim which has heen transformed into a cyst are found numerous small, generally oblong, yellow masses, in the centre of which traces of a cavity are still discernible, and two corpora nigra (p. 77). For want of a more suitable place, I wish liere to refer to the calcification of cor- pora lutea. Concretions of the bright yellow color characteristic of the recent corpus luteum have been found imbedded either directly in the stroma of the ovary or sur- rounded by a cyst-wall. They consist of a dense tissue impregnated with lime-salts. Occasionally these hard bodies may even be felt through the vaginal wall, and give rise to the impression that one has to deal with the sac of extra-uterine gestation, containing fragments of bone (Bland Sutton, Amcr. Jour. ObsL, Dec. 1892, vol. xxxvi. p. 908, and H. C. Coe, iiiclem, Feb., 1892, vol. xxv. p. 246). DISEASES OF THE OVARIES. 595 of the womb predisposes to it. It is often found together with an ovarian cyst on the other side. Ordinarily, chronic oophoritis is due to puerperal or gonorrheal infection. Other factors are venereal excesses, masturbation, and perhaps, unsatisfied desire. The abuse of alcoholic beverages seems also to produce the disease. Working on sewing-machines causes pelvic congestion, and may, therefore, become a cause of chronic oophoritis. Syphilis has also been thought to be a cause of the dis- ease — a supposition that has much to recommend it when we think of the frequency with which that disease localizes in other glands, and especially of the analogy with syphilitic orchitis. Nothing is more common than to find extravasated blood by microscopical examination of even apparently healthy ovaries, and larger collections of this kind can hardly fail to elicit an inflammatory reaction in the surrounding tissue. Thus hyperemia and hematoma may lead to chronic inflammation of the ovarian tissue, and to the formation of cysts (p. 593). Symptoms. — The symptoms are, as a rule, more or less masked by inflammation in the surroundings, especially salpingitis and local peritonitis, as well as retroflexion of tiie uterus. Very frequently both ovaries are affected. The patient complains of pain in one or both iliac fossae, to which often sacral pain is added. At times it extends with a neuralgic character to the rectum, the bladder, the hip, and down to the knee. The whole leg may feel heavy. The pain is always increased at the approach of the menstrual period, and often during intercourse — espe- cially if the uterus is retroflexed and the ovaries prolapsed — or during defecation and micturition. Any kind of exertion is badly borne. Some patients can hardly stand or walk for any length of time. In rare cases the pain appears regularly in the middle of the intermen- strual period. (Con)j)ar(' p, 437.) Menstruation is often irregular and too profuse. When the follicles and ova are destroyed, there Ibllows, on the contrary, a stage of anjcnorrhea. Very often these patients arc sterile or become so secondarily after the confinement or tiie abortion that gave rise to the disease. T^eucorrhea is (juite common. The digestion sufli'rs, the j)ationt loses flesh, and the nervous system is nnieh upset — disorders which may end in hysteria or hystero-epilepsy. A woman of the laboring class affected with this disease undergoes an enormous amount of suffering, and her wealthy sister may by invalidism b(! confined to her bed or her room Ibi' months or vears. Viarpiosi.s. — Often it is very difficidt oi- impossible to tell if a mass we feel through the roof of the vagina is an ovary or a tube, or both matted together in one mass by peritonitic exudation. Some- 596 DISEASES OF WOMEK times we can, however, distinctly feel the enlarged or prolapsed ovar}\ It lies more laterally and backward, and is of oval shape, while the swollen tube is sausage-shaped and lies nearer the edge of the uterus. The ovaries, or at least one of them (p. 122), swell regularly before each menstrual period, and decrease after menstruation. The tender- ness of the inflamed ovary is greater than that of any other part of the pelvis. The pain usually gets worse at the approach of the menses. How the examination should be made in difficult cases is described ou p. 561. Prognosis. — Chronic oophoritis rarely leads to death, although it may do so when an abscess forms and ruptures. On the other hand, it rarely ends in perfect recovery. It is at best a very tedious dis- ease, causing much pain for months or years, and it may even affect the mental condition, making the patient irritable, despondent, hys- terical, epileptic, and weak-minded. It often entails sterility. Treatment. — The treatment coincides in most respects with that for chronic salpingitis (p. 562). The patient should abstain as much as possible from sexual intercourse, and stay in bed during menstrua- tion. A depletion and much relief from pain are obtained by giving hot vaginal douches (p. 176), painting the vaginal vault with iodine (p. 175), and applying cotton tampons with ichthyol glycerin (p. 182). If this does not effect a cure, the galvanic current should be tried. I use it, as a rule, in the vagina (p. 248), and make the current as strong as the patient can stand, which in most cases is up to Fig. 314. Garrigues' vaginal electrode. 50 milliamperes (Fig. 314). If, besides the ovary, the cervix is inflamed, I apply the current there. For application in the in- FiG. 315. darrigues' cervical electrode. tcrior of the cervix I have had made cylindrical and slightly- curved electrodes of carbon (Fig. 315) in three thicknesses (y^, \, ^ -inch). Often scarification of the cervix (p. 194), or the application of a fly-blister, 2 to 4 square inches in size, every evening, to the iliac DISEASES OF THE OVARIES 597 region, has a good effect. Massage (p. 199) has been much praised, and may undoubtedly do good by causing absorption of perioophor- itic adhesions that compress or pull on the ovary. But if the ovarian inflammation were combined with pyo- or hematosalpinx, there would be the danger of pressing the contents of the tubes into the peritoneal cavity. The medicinal treatment should, above all, consist in the adminis- tration of tonics (p. 241). Tiie nervous troubles are often greatly benefited by the use of bromides. Chloride of gold has frequently seemed to me to reduce the size of the swollen ovary (p. 243). Desiccated parotid gland substance of sheep (3 to 6 tablets daily, each containing 2 grains) is praised. Rubbing with chloroform oil (p. 242) affords temporary relief from ])ain. A warm entire bath should be taken twice a ^\■cek. For those who can travel a treat- ment with the strong iodine brine of Kreuznach or the iron mud of Franzensbad, Marienbad, or Schwalbach, combined with the effects resulting from the change of air, new impressions, and the interrui)tion of marital relations, is often followed by decided improvement. The palliative treatment, carried out methodically and patiently, is of great value, but in some few cases nothing short of an operation will cure tiie patient. Even when laparotomy or colpotomy is per- formed, the ovaries need not always be removed. If the tubes are in a fair condition, the ovaries may be incised, diseased parts cut away, cysts enucleated, and the wound closed with a continuous suture of catgut. If tiie ovaries arc prolapsed, th(>v may be lifted up and fastened in a bett(>r position by stitching the round ligaments to the anterior abdominal wall ' (pp. 471, 470-478). But if the ovaries are much diseased, and if the tubes arc in a bad condition, tiie appendages should l)e removed on one or both sides (p. 563). Appendix. — Gijronia and Endofheliomn. — It is a peculiarity of the ovary that, examined microscopically, it shows so ni;iiiy variations that hardly two ovaries are alike, and it is, therefore, difficult to decide wliat is a normal structure and what represents an abnormal j)r()i -ess. (See p. 77, foot-note.) Two conditions have l)een described as diseases under the names of (jijroiivi and endof/ic/ioiiid,' which are intimately connected with * Pnlk, Aiiwr. Jour. Ob.tl., Sopt., 18',»1 ; Trans. Amer. Gyn. Soc, ]S'j;5, vol. xviii. p. 175. ' M. A. Dixon .Jones, "A IlitlitTto UndescrilR'd Disease of tiie Ovarv, Kndollie- lionia ciian{,'in,t^ to Anj^iotna :in<l Hetnatoina," X. Y^. Mfd. .lanr., Sept. -X, ISSU, and ''Anotiier Ilitlierto I 'ndts(iil)ed Disease of the Ovaries, Anomalous Menstrual BmJies" ((iyroma), ihiti, May 1(1 ami 17, ls;»0. t'onipare foot-note on p. 77. (Tvronia i.s, however, doubtless the same that has been descriited by I'atenko under the name of corpu.i Jibromm in Virchoiv's Arcliir, vol. Ixxxiv. p. 193. 598 DISEASES OF WOMEN. each other, aud one of which, endothelioma, under some circum- stances, is a normal development. Gyromas (Fig. 316) are convoluted, highly refracting masses, which in many instances replace most of the ovarian tissue. They are found both in the cortex and in the medulla (p. 71). In the former locality they are transformed corpora lutea — abnormal menstrual bodies — or corpora lutea of pregnancy (p. 74) ; in the latter they arise from Fi(3. 316. Ovary containing Corpus Luteum changed into Gyroma: a, cut surface of ovary; b, tube; c, c, gyroma. 1 arteries which become obliterated by endarteritis. The convolu- tions of gyromas are in the former case due to the convoluted figure of the structureless membrane — the membrana propria — of the fol- licular wall after it has ruptured ; in the latter they arise from the tortuous course of the arteries (Fig. 317). Those that are developed from the corpora lutea are due to a transformation of the medullary corpuscles which are found out- side and inside of the ruptured Graafian follicle. Instead of being absorbed or transformed into connective tissue, these me- dullary corpuscles become infiltrated with an clastic or colloid substance. In the vicinity of a gyroma the blood-vessels are in an abnor- mal condition : the capillaries are large and straight, the veins di- lated, and the arteries not infrequently sufiering from obliterating endarteritis and waxy degeneration. Gyromas are not found in the cow, pig, or sheep, and are probably always a pathological pro- duction.^ * Specimen from my salpingo-oophorectomy on Mrs. M , in St. Mark's Hos- pital, on Dec. 14, 1889. _ * Dr. Dixon Jones tliinks that what has been described as corpora lutea vera or DISEASES OF THE OVARIES. 599 Gyroma is found in all cases of endothelioma, but may also be found independently of the latter. Clinically gyroma is character- FiG. 317. Gyroma X I'K) (Fr. Foerster): GO, gyrorna traversed by delicate tracts of fibrous connective tissue: CO, newly-formed inflamed fibrotis connective tissue; AA, arteries witli sligbt sclerosis and hyaline degeneration ; V. vein in transverse section; B, capillaries. izcd by pain in the ovarian region, exhaustion, and marked nervous disturbances, which last may proceed so iar as hysteria and mental aberration. EwlotheJioiiKi (Fig. 318) is always an outcome of ovuhition, a growth of the structureless membrane of tlie follicular wall ([). 71). Simihir formations are found in the pregnant cow, pig, and sliecp. Some endotheliomas arc, indeed, nothing but c()rj)<)ra lutea of i)reg- nancy, but others are transformed gyromas, which, as we have seen, are always a j)athol(»gical product. Wliile gyromas may be found in an ovary in varying numbers, endothelioma is invariably single. It is eomj)oscd of large alveoli, or closed spaces, filled with endo- oorpora lutea of prcsmaiicy (p. 74) is nothing else hut auotnaloiis menstrual hodies, gyromas and endotheliomas changing into angiouui-s and lu'nuitonias (".Vnother liitherto L'ndeacribed Dise:i.se," reprint, p. 24) — a rather startling supposition (see p. 7Tj. 600 DISEASES OF WOMEN. thelial cells. The wall of the alveoli consists of coarse fibrous con- nective tissue, richly supplied with blood-vessels. The endothelial cells are globular, fusiform, or polyhedral corpuscles, mainly arranged Fig. 318. Endotheliomaof Ovary (Jones) : C, coarse connective tissue containing r, large blood-vessels, mainly venous in character; S, septum or prolongation of connective tissue into a closed space filled with globular and angular corpuscles in rows ; between the rows there are fat-globules and empty slits ; A, cellular elements. in rows and intermixed with dark brown fat-globules and pigment- granules. The rows are in many places interrupted by liglit gaps, probably caused by liquefaction of some of these cells. In the vicinity of an endothelioma there are large varicose veins and often aneurismatic arteries, which occasionally rupture, and cause hemorrhage under the albuginea or into adjacent cysts. Sometimes some of the cells are transformed into red blood-cor- puscles, while others fuse together, forming ve.'^sels around the new- formed blood. (See Hematoma, p. 586.) The endothelial growth replaces gradually the normal ovarian tissue, and may occupy the whole DISEASES OF THE OVARIES. 601 ovary, which, however, is not much increased in size, and sometimes even smaller than normal. The ova are diseased or destroyed. The clinical features of endothelioma are lancinating pain in the region of the ovary, progressive emaciation, pronounced pallor, and great weakness. By destroying the patient's health and rendering her sterile the affection is of great importance. Both gyroma and endothelioma originate in chronic oophoritis, and, again, they cause inflammation in the surrounding tissue. Some path- ologists take endothelioma to be a variety of carcinoma, which fits well with the clinical aspect. As the presence of these conditions can only be proved by micro- scopical examination, they cannot be a guide in regard to treatment, but when, after oophorectomy, they are found in the removed ovaries, they bear witness to the justifiableness of performing the operation. CHAPTER VI Neoplas]ms. The ovaries are very frequently the seat of neoplasms. Some are cystic, others are solid. A. Ci/sts. Pathological Anatomy. — Ovarian cysts offer a great variety in their anatomical structure, but they may, nevertheless, be reduced to a few I. Dropsy of the Graafian Jollick {hydrops folUculi), assuming one of three forms : 1, a conglomeration of many small cysls in the interior of the ovary ; 2, a similar formation, but with pedunculated cysts, by which the whole ovary may become like a bunch of grapes (Jkohi- tanski's tumor) ; and S, the develo])ment of a few or one large (yst ; 11. Proliferating cysts, occurring in three varieties: 1, glandidar, 2, papillary, and 3, mixed: III. dermoid cysts; and, lY. tubo-ova- rian cysts.' ' While the aiitlior was collecting materials for his work on I)iit(i)iii.<i.< nf Ontrlmi. (,)/!<ln 1)1/ m^'iiis (if till- J'JjdtiiiiKitiDii of tlicir (''i)iti'iil.<, 111' had the advantat^es of wit- nessing all tile ovariotomies performed in tiie Woman's Hospital in the State ol' New York during eif^hteen months, and of ohtaiiiiiif,' a jiart of the Ihiid and tiie sac and the ovary of the opposite side when it was diseased. Not only was the flnid examined ehemieally and nneroseo])ically in every ease, hut many hundreds of specimens were cut from the hardened sacs or small ovaries. In that work he refeix also in many places to the solid part of ovarian cysts, and if other occupations have prevented him from increasing? the material and utilizin<r it for a speeial essay, his 1)ersonal aeqiiaint.ance with all slaves of cystic defjeneratioii n\' ovaries has eiial>l<'(l lim to better understand and value the work of other investigators in this domain. 602 DISEASES OF WOMEN. I. Dropsical Graafian Follicles. In studying chronic oophoritis we have seen (p. 559) that often in that disease many small follicles may be transformed into cysts, and Fig. 319. Ovary with many Dropsical Follicles (Leopold). that a single follicular cyst may cause the absorption of the rest of the ovary. Thus there is a gradual transition from oophoritis, an Fig. 320. Bilateral Oligocystic Ovarian Tumors (Hooper). inflammatory disease, to cystic degeneration, a neoplasm, and it is in reality, in .some cases, only the size of the specimen which decides us in calling tlie disease by one or the other name. The proof that a cyst is of follicular origin is the presence of the ovum ; and by the con- formity of the structure and the fluid we are led to regard larger cysts^^ DISEASES OF THE OVARIES. 603 even when the ovum has disappeared, as being developed from follicles. If many follicles are affected simultaneously (Fig. 319), the ovary does not obtain very lai'ge dimensions, indeed hardly more than the size of a hen's egg. The stroma may be unchanged or infiltrated with medullary elements. Gradually it is absorbed. Fig. 321. Rokitanski's Tumor, one-third actual size (Tail) ; on the right is seen the adherent omentum. Sometimes a f(;\v follicles become cystic, forming what is called an oligocystic tumor (Fig. .'>20). Veiy rarely the partition between two 604 DISEASES OF WOMEN. such cysts ruptures, so that they communicate. As a rule, only one Is developed ; or, predominating iu its development, causes the atrophy and disappearance of the others. If only one follicle undergoes cystic degeneration, it may form a tumor of the size of a man's head or even a uterus at term.^ Such a large cyst is strictly monocystic. Nowhere are found rem- nants of partitions. The icall is white, and consists of two layers of dense fibrous connective tissue held together with a layer of loose connective tissue, iu which run blood-vessels. The arteries are thick- ened in consequence of endarteritis. These two layers correspond probably to the tunica propria and the combined tunica fibrosa and albuginea (p. 71). The outside is covered with a short coluiunar epithelium ; the inside has a similar epithelium with somewhat longer cells. The fluid is serous, alkaline, and almost colorless. It does not coag- ulate spontaneously nor by heat. It contains paralbumin, the presence Fig. 322. Ovaries with Pedunculated cysts (Winkel) : a, anterior wall of uterus cut open, showing a primary sarcoma of the body; 6, c, ovaries with multiple pedunculate cysts; d,e, tubes; /, posterior wall of bladder. of which is characterized by its precipitation when the fluid is boiled with a small amount of acetic acid, tlie })recipitate being redissolved by adding an excess of the same reagent. It contains only a few granules and no cellular elements. These monocystic and oligocy.stic tumors are much rarer than the proliferating and dermoid cyst.s. RohUanski^s Tumor (Fig. 321). — Much rarer still is that species ' I have seen it contain a i)ailful of fluid [Diagnosis, p. 9). DISEASES OF THE OVARIES. 605 of ovarian cystic tumor which from the name of the man who first described it is called Rokitanski's tumor. In fact, only a few cases are known. This seems always to be a bilateral affection. The tumors grow slowly. They are of moderate size, between that of the fist of a man and that of the head of a four-year old child. They are composed of innumerable cysts varying from the minutest size to that of an orange. The wall is thin and lined with columnar epithelium ; the contents are limpid ; and the ovum is nearly always found in every cyst. The cysts may become more or less pedunculated, so as to impart to the whole tumor the appearance of a bunch of grapes. Fig. 323 A. C V^A ^K A. Inner Pnrfaoc of filandular Ovarian Cystoma ( [lartly fliaprainmatic) x 120: (7, connective tissue; ^, ('f)itlieliiim ; <■, howl-shaped 'Icpression witli STuall oiteniii},''. '/, a similar one. the opeiiint,' cIosiiiK up; r.f, huds of epithelium, growing from tlie bottom of tlie howl: ,'7.7. depressions in the conneelive tissue, from which the epithelium lias been removed. i5. Same a.s r in FIr. -SlCi A, enlarRed :W) times. It is comi)osed of two pouches unitintr at the top. The centre of each is uudertroinK Ii(|uefaction. A kind of tliready nuiterial is seen exten<lintr from the periphery into tlie interior of the pouch Ijctween the epithelial cells (cement sulistauce). Fig. 322 .'^liows the ovaries with a few pcdunciilatod cvsts on the surfice, II. Prolifrrafhif/ Ojixts. — Proliferating cysts are also called myxoid cj/sforiuift, in opposition to the dermoid cystomas, bcranse their inner surface re-sembles a mticous membratie. The epithet "proliferating" 606 DISEASES OF WOMEN. has been given them because they, differing entirely from the above- described large cysts due to dropsy of the follicle, which are strictly monocystic with a snKX)th inner surface, produce new cysts or papil- lary growths from their inner surface. With regard to these two different kinds of proliferations the myxoid cystomas are again sub- dividt^l into two groups — glandular myxoid cystoma and papillary myxoid cystoma. a. Glandular ovarian cysts have a wall composed of the same two layers we found in the case of follicular dropsy, and a similar external epithelium, but the internal epithelium undergoes a remarkable pro- liferation, which results in the development of gland-like growths. This epithelium is polymorphous ; that is to say, different forms of cells — columnar, goblet-shaped, and flat — are found in it, but the long columnar is the predominating variety. It is stratified and forms pouches, which at first are placed regularly side by side, and are of about the same size (Fig. 323) ; but in consequence of the continued proliferation of the epithelial cells some of these pouches become closed, thus forming a secondary cyst in the wall of the primary cyst. At first, it is a nearly solid mass of epithe- lial cells, but soon the cell-body begins to melt, setting the nucleus free (Fig. 324), and forming a fluid in the secondary cyst. This Fig. 324. Melting of Epithelial Cells in Secondary Cyst in the Wall of an Ovarian Cyst. process can be followed under the microscope, and, by analogy, we may infer that the same takes place in the primary cyst. When the secondary cyst is formed, the same process of proliferation is repeated, so that continually one generation of cysts is formed in the wall of another. Simultaneously with this production of new cavities a reduction in their number takes })lace by the absorption of the partition which separates two cysts from each other. At first there is only a small hole of communication between the two sacs, but gradually the open- DISEASES OF THE OVARIES. Fig. 325. 607 Small Glandular Ovarian Cyst, with beginning absorption of partition. Slightly reduced from natural size (Dorani. Fig. 326. Lar^;< i .,ai,.iiilar Ovarian Cyst, sliowiiig nuiiicnius .secondary cy.^ls and rid^'t's as remnants of absorbed partitions; n, primarv cyst turiieii insi<lc oi'it iind stulVcd witli cuiton ; hb, secondary cysts; cr, reiniianls of iibsorljed panilions.' ' Sj)e<inicn from my ovariotomy on Mrs. M. S- Aug. 14, 18'J0. It contained si.xtcen quarts of liiiid. -, at St. .Mark's llospit.ii, (508 DISEASES OF WOMEN. ing increases in size until, finally, only a low ridge remains as a rem- nant of the former partition (Figs. 325 and 326). By this continual proliferation of epithelial cells, formation of new cysts, and absorption of partitions very large tumors are formed, in which, as a rule, one cyst predominates, but there are invariably found a greater or smaller number of secondary cysts in its wall. These cysts are, therefore, always muUiloeular from a pathological standpoint, even if from a surgical they may be regarded as unilocular. The healthy ovarian tissue disappears entirely as soon as the tumor reaches a few inches in diameter. The glandular variety is by far the most common, and forms the largest tumors of all. Their growth may, indeed, become so enor- mous that they weigh more than the rest of the body (Fig. 327).^ Fig. 327. Enormous Glandular Ovarian Cystoma (Rodenstein). Fig. 328, on the other hand, represents sucli a glandular cystoma found in a new-born child, and enlarged thirty times. The outer layer of tlie wall corresponds to the albnginea, is smooth, of dense texture, a pearl-gray or white color, and takes no part in the formation of secondary cysts, which exclusively takes place in the inner layer. The inner layer furnishes the connective tissue which, together with the inner epithelium, enters into the composition of the secondary cysts. It is of a reddish color, slightly uneven, and velvety like the inside ' The figure represents the patient after death at the age of forty-five years. The tumor stood three feet high, covered the breasts, went down to the knees, and weighed 146 pounds (Dr. L. A. Rodenstein, Amer. Jour. Obst., 1879, vol. xii. p. 315). DISEASES OF THE OVARIES. 609 of the stomach. Often it is brown from impregnation with extrava- sated blood, or yellow in consequence of fatty degeneration. Some- times it has hard spots, due to calcareous infiltration. Fig. 328. Congenital Mnltilocular Cystoma, X 30 (Winckel). From the outer layer may grow small excrescences, covered with the common short columnar epithelium (Fig. 329). Fig. 329. PaplUoraatous Excrescence on Outer Pnrfacc of Myxoid Proliferating Glandular Cystoma of Ovary (natural size): A, seen from above; B, sagittal section of the same, with part of cyst-wall, showing that the papilloma was only connected with the outer part of the wall, and did not spring from the interior of the cyst: a, papilloma, sagittJil section through pedicle; I), main cyst; c, secondary cyst, partially filled with cheesy contents, partially empty ; d, secondary cyst with cheesy contents. In the loose connective tissue betwoon the two layers of the wall are found ])lain muscular fibers, osj)ocially near the ligament of the ovary. Sometimes cysts have boon found there, and even a corpus luteum. The glandular cy.stoma has, as a rule, a pe<liclo. Relation to Omcer. — licing a neoplasm ciiiefly composed of epi- 30 610 DISEASES OF WOMEN. thelial cells and a stroma of connective tissue, the glandular cystoma approaches the structure of carcinoma. The diiference is that glandu- lar cystoma does not affect the lymphatic system, does not give rise to relapse after extirpation, and has tlie tendency to produce more or less fluid in its compartments. If, however, the epithelial prolifera- tion predominates nuich, and the formation of cysts stops, the condi- tion is passing into tiiat of carcinoma. The appearance in the wall of epithelial cells of nmcli larger size than those commonly found in the wall of ovarian cysts is likewise characteristic of beginning car- cinoma. Contents of Glandular Cysts. — In microscopical new-formed cysts nearly the whole body is one solid mass of epithelial cells. As a rule, the contents become more fluid as the cyst grows, but there are tumors called parvilocular, in which each compartment never reaches any considerable size. The whole tumor is like a honeycomb, and the contents never become more fluid than a thick gelatinous mass, in which even the microscope fails to find any structure. The fluid in common ovarian cysts is of a gray, yellow, or brown color. It may be limpid as spring- water, or so filled with solid bodies as not even to be translucent. Usually it is more or less viscid. The specific gravity of the specimens examined by me varied from 1013 to 1062. Its reaction is alkaline. As a rule, it does not foam much, if at all, on being withdrawn from the cyst. Generally ovarian fluid does not coagulate sponta- neously; but by being boiled, as a rule, the contents ^ are more or less completely turned into a solid mass. 0i ^ Ovarian fluid possesses a remarkable degree of resist- ance to decomposition : while in ascitic fluid all form- ^ elements are destroyed within a few days, in ovarian fluid they are sometimes preserved for weeks or months. ^ „ The fluid contains nearly always paralbumin. n^ As a rule, ovarian fluid is full of a variety of form- elements: red blood-corpuscles, epithelial cells (either O O intact or metamorphosed), nuclei, pigment-granules, w ® ^ finely granular globular bodies like lymph-corpuscles Red Biood-cor- or colorlcss blood-corpusclcs, pus-corpuscles, spindle- shaped cells, crystals of cholesterin and of indican. Figures 300-31 3 show most of these bodies. A few remarks about them will suffice. Besides the well-known common shape of red blood-corpuscles we find crenated, rosette-shaped, thorn-apple-shaped, and hematoblasts (Fig. 330). Epithelial cells (Fig. 331) are almost constantly found. They are columnar seen in side view, and multangular in front view. All show signs of fatty degeneration. When this process reaches a high degree, DISEASES OF THE OVARIES. Fig. 331. 611 Epithelial Cells, single and grouped, in front and side view. the epithelial cells appear as so-called gorged corpuscles, or Bennett^s large corpuscles (Fig. 332). Often vacuoles are formed in epithelial Fio. .S.32. Bennett's Large Corpuscles, or Nunn's Gorged Cori)uscles— i.e. epithelial cells in fatty degeneration, cells, which probably are a kind of disintegration leading to the destruction of the cells. Fig. 333. Colloid Corpuscles. 612 DISEASES OF WOMEN. Colloid corpuscles (Fig. 333), large and small, are probably either parts detached from epithelial cells or a transformation of the whole cells. Fig. 334. Fio. 335. Horn-cells. Proliferating Cells. Horn-cells (Fig. 334) are epithelial cells that have lost their proto- plasm, have shai'p ridges, and look horny. Fig. 336. Fig. 337. Ameboid Bodies. A Large Bennett Cor- puscle with ame- Doid movements. Proliferating cells (Fig. 335) are large cells containing a brood of vounger ones in their interior, from which they escape to lead an inde- pendent existence. Fig. 338. Bennett's Small Corpuscles, or Drysdale's Corpuscles— i. e. nuclei in fatty degeneration. Fig. 339. Fig. 340. Cells with nucleus and fine dark granules (enlarged colorless blood-corpuscles ?) Flakes of epithelium, the cells melt- ing and setting the nucleus free. In quite fresh fluid it is not rare to find cells with ameboid move- ments. In Fig. 336 we .see the same two cells in three different stages of separation and amalgamation. DISEASES OF THE OVARIES. Fig. 342. 613 Fig. 341. Fat-granules. Spindle-cells from a myxofibromatous ovarian cyst. Drysdale's corpuscles (Fig. 338) are small globular or polyhedral clear bodies with a small number of shining granules. My inves- FiG. 843. fP Cholesterin. tigations have led me to believe that these bodies are nuclei of epi- thilial cells in fatty degeneration (Fig. 340). Fig. 344. rajdllary Ovarian Cyst sprinnintr from tlio liiliim of tlio ovnry, ttic preater part of wliich is not involved in tno niortiifl jtrowtli. Tlit- fvst lias forot-d its way betwoun the layers of the broad liKanient as far as the Fallopian lube (Doran). Ovarian Ihiid contains also round cells, each with a nucleus and finely granular ])rotoplasin (1^'ig. 339), tlie nature of" which is un- certain. Perhaps they an,' enlarged colorless blood-corpuscles. 614 DISEASES OF WOMEN. b. Papillari/ Ovarian Ci/sts are not so common as glandular, being found in only one out of ten ovariotomies, and they do not ac- quire such large proportions. They contain a comparatively sniall number of secondary cysts. From their insid(i spring dendritic or cauliflower-shaped growths, calksd papillomas (Fig. 344), which may fill the secondary cyst in wiiich they grow, and break through its wall into a neighboriug cyst, or perforate the wall of the primary cyst, so as to come to lie in the peritoneal cavity, where they may cover the outside of the ovary and neighboring parts. They may eveu penetrate tiie uterus, the bladder, the rectum or other viscera, so as to form one mass with them. The ends of papillo- matous growths may also coalesce in the interior of the cyst, thus forming a separate compartment or secondary cyst. The papillae range in size from that of a pea to that of a small orange. They are sessile or pedunculated, white, dark red, or black. The inside of papillary cysts is usually lined with a ciliated epithe- lium, and the fluid in their interior is not viscid or colloid, but more watery. This kind of tumors is often bilateral, and develops in a consider- FiG. 345. pvu Superficial Papillomata on both ovaries (Coblenz) : RO, right ovary ; LO, left ovary ; fu, fun- dus uteri ; he, hyaline cyst ; pv, papillary vojretations ; cy, cystic tumors ; hg, blood-vessels „ hm, hydatid of "Morgaftni ; old. abdomiiia! orifice of right tube: o^v, abdominal orifice of left tube ; kc, calcareous deposits; //. broad ligament; Ir, round ligament ; av, Infundibulo- pelvic ligament; id, uterus; ;jri(, vaginal portion of uterus; inv, vaginal wall laid open. able number of cases between the folds of the broad ligaments. The development is much slower than that of the glandular variety. It DTSEASES OF THE OVARIES. 615 is often accompanied by ascites, and, if removed by tapping, the fluid reaccumulates in a short time. It is not rare to find grains of a sand-like substance in the papillo- matous masses, so-called corpora arenacea, or sand-bodies, like those forming in the brain the tumor called a psammoma. In this variety normal ovarian tissue is preserved longer than in the glandular. Superficial Papillomata. — Papillomata on the outside of an ovary are not always due to rupture of a papillomatous cyst. They may also develop originally on the surface (Fig. 345). c. Mixed Proliferating Ovarian Cysts. — In one and the same cys- toma some cavities may be of the glandular type, others of the papil- lary. Thus there seems not to be any radical difference between the Fig. 346. Portion of the Wall of a Dermoid Ovarian Cyst (Ziegler) : a, wall ; ft, elevation composed of (if fatty and eiitaiieoiis tissues : c, liairs ; (/, tectli. two varieties — a point to wl)ich we shall come back in sj)caking of tlie origin of ovarian cysts. From the liistoiy of the <l('V('loj)ment of the ovaries (p. 20) we know that from a very <'arly period these bodies are l)uilt up of two ehiinents — epithelial (;ells and connective' tissue. In the glandular cystoma tiie Ibrnier ))re(lominat<'s, in tiie papillary the latter. III. Dermoid C^.sis. — Dermoid (;ysts diller entirely from all those 616 DISEASES OF WOMEN. liitherto described, both as to sac and contents. While in the other kinds of cysts the inner surface reminds one of the mucous membrane of the intestinal canal, in the dermoid variety it is like skin, not only in general appearance, but in regard to the elements that enter into its composition (Fig. 346). Thus the inside is covered with a thick layer of stratified epidermal cells, the most superficial, flat and with- out nuclei, the deeper, round or polyhedral. Outside of this comes a layer like derma, then one of subcutaneous adipose tissue, and finally a layer of fibrous connective tissue corresponding to the outer layer of other ovarian cysts. The derma is often raised in more or less regular papillae. It may contain sudoriferous glands, with ducts opening on the inner surface, or sebaceous glands opening into the sheaths of hairs. Such hairs spring often from a small prominence and may form a switch several feet long, rolled up into a ball, and usually of a reddish yellow color. In other places may be seen teeth, often in large number (up to three hundred have been found in one cyst). Sometimes several teeth together are inserted in one piece of bone. Even a kind of shedding may go on, a tooth with a decaying root sitting over a young healthy one, just as in the mouth the milk- teeth are eroded and thrown off by the permanent teeth. If there are many teeth, the bicuspid form predominates. If there are only few, they are generally like the incisors or canines. Besides these attributes of the skin, many other tissues, or even simulacra of organs, have been found in the wall of dermoid cysts : bones (usually of the flat type), cartilage, striped and plain muscle- fibers, gray brain matter, nerves going to the teeth, mucous membrane like that of the intestine, a body like the submaxillary gland, a breast with papilla, a metacarpus with articulations, a trachea, a heart with mitral valve, columnse carnese and chordae tendineae,^ and even an eye. The outer surface of a dermoid cyst is, as a rule, of a dull gray or greenish color with orange or ocherous ])atches. Dermoid cysts are small or of medium size, rarely exceeding that of the head of an adult. Commonly only one ovary is affected, but the occurrence of the disease on both sides is not rare. Two or three dermoid cysts may develop in the same ovary. In the course of time, when the separate cysts grow, the partitions between them are absorbed, and they are blended into one. A. dermoid cyst may form adhesions and ru])ture into another organ or on the surface of the body. If it opens into the bladder, hairs may be eliminated with the urine (piliniiction). Dermoid cysts may give rise to metastasis in the shape of small yellow nodules on the peritoneum, of characteristic composition. A dermoid cyst in one ovary may be combined with a proliferating ' A. W. Johnstone, Trans. Amer. Gyn. Soc, 1893, vol. xviii. p. 305. DISEASES OF THE OVARIES G17 myxoid cystoma in the other. In the same ovary some compart- ments of a cyst may have the dermoid and others the myxoid type, and the two kinds may even be represented in one and the same small secondary cyst. Contents of Dermoid Cysts. — The fluid contained in dermoid cysts is characterized by its richness in fat-globules and cholesterin. It may be so thick that it hardly can pass through a canula, and solidifies as soon as it is exposed to the air. It contains often lumps of solid fat, and in a few cases this has been found in the shape of a large number of balls of the same size and as round as billiard- balls. This fluid has a nauseating odor. It does not give the reaction of paralbumin. It contains cholesterin, urea, oxalic acid, leucin, tyrosin, and xanthin. Dermoid cysts are much rarer than proliferating cysts, less than 4 per cent, of ovarian tumors having this type. Before ])uberty this is, however, the })redominating variety. Fre- quently its occurrence is combined with an imperfect development of the genitals. Similar cysts have been found in other parts of the body, such as the head, the neck, the sacrum, the ])it of the stomach, the perineum, the testicle, the uterus,' the organs of the chest, and other abdominal organs, etc. ; but they are more frequent in the ovary than anywhere else. IV. — Tabo-ovarian Cysts, or Hydrocele of the Ovary. — Tubo- ovarian cysts consist of a combination of a cystic salpingitis (p. 572) with a cyst of the ovary. They have the shape of a retort. The line of demarkation between the two organs is, as a rule, distinctly visible. The fimbriae may have disiippeared altogether or may be spread over the outer surface of the ovarian cyst ; or Ave may find them inside, floating from the inner surfiu-e or attached to it from end to end. The tubal part is covered with peritoneum, and the inner surface has in the beginning ciliated columnar ej)ithelium, but later the cilia disappear, and the cells may become flattened. Tiie uterine oj)ening commonly remains pervious, so that the con- tents may from time to time, when pressure increases, be evacuated through the vulva. Bland Sutton^ calls tubo-ovarian cysts hydrocele of the ovary, and says there is good reason to believe that tiiey arise in a tunic of" the peritoneum that occasionally invests the ovary, much in the same way that the tunica vaginalis clothes the testis. The oviii'v is replaced by ' W. W. Stewart of ('oliinil)us, Ga., Med. Record, Nov. 11, iS't:',, vol. xliv. No. 21, p. 648. ' IJIaiKl Sutton, J tisf'tuieis of the Ovaries and Tiibex, Philadelphia, 1S91, p. 111. 618 DISEASES OF WOMEN. a cyst which communicates with a distended tube, but the orifice of oommunication is an adventitious opening, and does not represent the abdominal ostium of the tube. What is usually called hydrops tubae profluens this author calls intermitting ovarian hydrocele. As a rule, the affection is unilateral. All kinds of ovarian tumors may undergo this blending with cystic salpingitis. All that has been said above about the size of the tumor and the nature of the fluid of ovarian tumors applies, there- fore, to tubo-ovarian cysts. Probably a catarrhal salpingitis (p. 555) is a forerunner for the formation of this kind of cyst. A hydrosalpinx (p. 575) is formed, adhesion to the cystic ovary follows, the partition becomes atro})hied, and finally the two cavities form one. All ovarian cysts may be unilateral or bilateral. Dermoid cysts are oftener only found on one side ; proliferating papillary cysts and RoUitanski's tumor, on the other hand, are nearly always bilateral. Even in unilateral cases of ovarian cysts the other ovary very fre- quently shows beginning cystic degeneration. Pedicle. — Ovarian cysts in most cases rise up into the abdomen, and are connected with the uterus by means of a pedicle, which facil- itates their removal. In some cases, however, — and we have seen that this applies particularly to the papillary variety, — the development takes place downward, so that the cyst is situated between the layers of the broad ligament, more or less close up to the uterus, and has no pedicle. The pedicle of ovarian cysts varies much in size and composition. It may be long or short, thick or thin, broad or narrow. It contains always the ligament of the ovary and part of the broad ligament, and, as the tumor grows, the Fallopian tube is drawn in, so as to form part of it. The tube, as a rule, is both elongated and thickened. The arteries may become as thick as the radial, and the veins as a finger. Besides there are lymphatics, nerves, smooth muscle-fibres, and con- nective tissue, all forming a bundle covered by a peritoneal sheath. Torsion of Pedicle. — The longer and thinner the pedicle is, the more easily it may become twisted, the tumor rotating around its perpendicular axis. Such rotation can only occur, if there are no adhesions, and the tumor is of moderate size. It is probably due to the peristaltic movement of the intestine, the differences in the state of emptiness and fulness of intestine and bladder, the irregular development of secondary cysts, by which the centre of gravity changes, and to the movements of the patients. It is often caused by the development of the pregnant uterus. It is much more frequent with dermoid than other ovarian cysts. Sudden twisting of tiie pedicle leads to gangrene and fatal peri- tonitis. If it develops slowly, it causes edema and hyperemia of the DISEASES OF THE OVARIES. 619 wall, hemorrhage into the wall and the cystic cavity, or suppuration. The cyst-wall is dark red — nearly black. If the torsion continues, the whole pedicle may be severed ; but in the meantime, as a rule, adhesions form with other organs, from which the tumor henceforth derives its nourishment. Even the uterus has been found as part of the severed mass. Large cysts have also been found lying loose in the abdominal cavity, without any kind of attachment.^ Tiie rotation of the tumor and twisting of the pedicle may involve the intestine, and cause its occlusion. On the other hand, the twist- ing may effect a cure of the cyst by causing atrophy, fatty degenera- tion, and calcification of the diminished tumor. Adhesions. — As long as the ovarian cyst is covered by its columnar epithelium, it slides freely over the surfaces with whicli it comes in con- tact; but, when the epithelium is rubbed off or covered by infiamma- tory exudation, adhesions to the surroundings, such as the bladder, the uterus, the intestine, the omentum, the liver, the abdominal wall, etc., are easily formed. These adhesions may be like long cords, which are easily torn or divided between two ligatures ; or extend over a large surface, when they may place considerable difficulties in the way of the removal of the tumors. By extending downuanl between tiie layers of the broad ligament and into its base, tlie tumor may be- come adherent to tlie ureter and the large blood-vessels of the pelvis. Ascites. — An accunmlation of ascitic fluid in the peritoneal cavity sometimes accompanies an ovarian cyst, especially tlie proliferating papillary variety. Tiie fluid may be mixed witli blood, wliieli is a sign of a deteriorated constitution. Fusion. — When an ovarian tumor develops in each ovary, the two may become adherent to each other in the abdomen ; the conunon ])ar- tition may be absorbed, and the two form one tumor with this ]K'culi- arity that it has two pedicles, one attaciicd to each cornu of the uterus. IntraUfjameiitoHs and E.vtraperilone(d Developinenf. — We have seen that while most ovarian cysts have a pedicle, some are sessile. They develop downward between the layers of the broad ligament, and may extend far away from their base outside of the peritoneum, going in between th<! uterus and rectum or the uterus and bladder, and reaching the; ciccum, colon ascendens, and even the kidney. All kinds of ovarian cysts are liable to become retroperitoneal in this way, but this development is found most frecpiently in ])aj)illary proliferating (ysts. lleinorrhaf/e. — At times more or less considerable amounts of blofxl may Ix' poun-d into the cystic fluid, with which it mixes, and to which it imj)arts a dark red or l)rown color. Tiiis hemoj'- rhage may come from erosion of vessels in the partitions which aie being al)sorbe(l, from ulceration of the wall, or torsion of" the pedicle. ' I. 1^. Stoiu', \Vasliiii),'t(>n, I). ('., Mi'/niul Tiiiiinr, \>\i. S jirid Id. 620 DISEASES OF WOMEN. Suppuraiion. — The wall of a cyst may become inflamed, and the contents changed to pus. This grave accident may he due to torsion of the pedicle, but is most frequently attributable to puncturing of the cyst without sufficient antiseptic precautions. It may be caused by puerperal infection or occur spontaneously. In the latter case pyogenic bacilli are supposed to have worked their way in from the outer world through the genital canal or the intestine. Rupture. — An ovarian cyst may burst and pour part of its con- tents into the peritoneal cavity, where a bland fluid is al^sorbed and eliminated, especially by the kidneys. Even thick colloid con- tents of cysts, if not mixed with blood or pus, do not irritate the peritoneum, although their absorption requires more time. But bloody, purulent, or ichorous fluid, as well as the contents of dermoid cysts, causes more or less violent peritonitis or death from shock. The rupture into the peritoneal cavity may give rise to the for- mation of a metastatic tumor of the peritoneum, of which more will be said presently. Rupture may also occur into the intestine, the stomach, the vagina, the bladder, the Fallopian tube, or through the abdominal wall, especially the umbilicus. Under favorable circumstances the rupture may effect a cure of the disease. Evidence of rupture is found in 8 or 10 per cent, of all ovarioto- mies. This accident may be due to a fall, a blow, a kick, or similar violence. It may also be caused by torsion of the pedicle, by great thinness and brittleness of the wall, by the development of unusu- ally numerous secondary cysts or perforating papillomata, fatty de- generation, or hemorrhage into the cyst. Calcification and Ossification. — We have mentioned above (p. 609) that frequently calcareous incrustations form hard plates in the cyst- wall. This process may acquire such proportions that the whole tumor is changed into a hard shell, in which even bone-corpuscles may be found. Cancerous Degeneration. — We have seen above (p. 610) that the proliferating glandular myxoid cystoma may become malignant. The same is the case with dermoid cysts, and when once degeneration into sarcoma or carcinoma has taken place, not only neighboring organs may l)e involved, but metastatic deposits may form in remote parts of the body. It has been found that 20 per cent, or more of all ovarian tumors become cancerous. Metastasis. — Pa})illomatous cysts have a tendency to cause the pro- duction of small yellow nodules on the peritoneum. After removal of the tumor these may disai)|)ear or become innocuous by becoming calcified. Glandular and dermoid cvsts are much less liable to form such DISEASES OF THE OVARIES. 621 metastases, except the glandular variety with gelatinous — i. e. serai- solid — contents. When in consequence of rupture of the cyst before or during operation part of the contents enters the peritoneal cavity, it has in some rare cases given rise to the formation of large gelat- inous masses covering tiie peritoneum ; which condition is called pseudomyxoma of the peritoneum (\yerth) or gelatinous disease of the peritoneum (Pean).^ The gelatin is held in the meshes of fine membranes of connec- tive tissue, which may be covered with endothelium or columnar epi- thelium, and carry fine blood-vessels. In some cases this formation may be explained as a transformed peritonitis, but in others it is cer- tainly a growth of small solid particles of tlie tumor which go on forming a tumor in the peritoneum similar to the one in the ovary, from wiiich they were broken loose at the time of the operation. The Origin of Ovarian Cysts. — In speaking of the division of ovarian cysts into different classes (p. 601) we have seen that one class, the so-called dropsy of the Graafian follicles, is indisputably formed by a pathological development of one or more of such folli- cles. It is likewise sure that a corpus luteum may be converted into a cyst. As a rule, the cysts of this origin remain small as a hazelnut ; but they may attain the size of an adult's head. As to tiie second class, the proliferating cysts, there reigns yet con- siderable diversity of opinion in regard to their origin, and it is very likely that it differs in different cases. Microscopical examination has shown that both the glandular and the ])apillary variety may de- velop from a Graafian follicle. Another source may be the germinal epithelium, which in some ovaries, even of adults, forms pouches extending into the stroma of the ovary, much like the columns of epithelial cells giving rise to the primordial ova and primary folli- cles (p. 28). Even those tumors which have ciliated epithelium may have this origin, as part of the ovary, probably by extension from the tube, may have ciliated external e|)itheliuin instead of ])lain columnar. Some claim that the papillary cystomas are developed from remnants of the Wolffian body growing into the ovary from the liilum ^ The source of the glandular variety is by some thought to be a de- generation of the intima of tiie arteries in the ovary. ( 'olloid deposits an; often found in the stroma, the Gnuifian follicles, or a corpus lut(!um ; but there is no evidence that they are th<' starting-])oint of proliferating cysts. We find, likewise, frequently small (ysts without epithelium in the ovaries, but it is inilikely that formations of so'epi- ' A ca-se of the kind is described on p. 4() of my Dinffjinsin. ' In n'lfani to the liis'ofienosis of the pajjilhiry cystomata of the ovary a pood Bvnopsis of known facts and vahiahle new observations are found in articles by .T. WhitridRc Williams in ./oA/is [[iipkinn IFoMpilal liulletin, No. 18, December, lS9I,and Report in Patholofjij, II., Baltimore, 1892. G22 DISEASES OF WOMEX. thelial a character as proliferating cystomas originate in them. It is not proved that connective tissue can be transformed into epithelium, and it is, therefore, unlikely that proliferating cystomas can develop from the stroma of the ovary. As to the origin of dermoid cysts, the generally accepted theory is that of invagination. The ovary is developed from the axis-cord, in which it is impossible to distinguish the individual blastodermic layers. In the collection of mesoblastic cells destined to form the ovary may be included cells belonging to the epiblast, to ti)e hypoblast or to other parts of the mesoblast than those required for the ovary. This hap- pens most commonly with the epiblastic cells, which form epidermis, teeth, nails, hair, tiie cutaneous glands, and the central nervous sys- tem ; more rarely with the mesoblastic cells, forming bone, cartilage, and muscle-tissue; and least frequently with the hypoblastic cells, whose role it is to form the epithelium of the intestine and the glands connected with it. When not only extraneous tissue, but more or less perfectly formed organs are found in a dermoid cyst, it is, however, a question if this must not rather be looked upon as a case of foetus in fostu; that is, two fetuses, one of which has hardly developed and is included in the other. Etiology. — Little or nothing is known about the circumstances that cause the development of ovarian cysts. They are met with at all ages. Simple cysts have been found in the ovaries of fetuses. In young children even multilocular cystomas have been found in a small number of cases, and Fig. 328 (p. 609) represents a congenital cystoma of this kind. Before puberty the dermoid variety predominates. Commonly ovarian cysts appear, however, during the period of greatest sexual activity, between tlie ages of twenty and fifty years. Single women are proportionately much more liable to the disease than married, the reason for which may be sought in the physiolog- ical rest which the ovaries enjoy during pregnancy and lactation. Sometimes several members of one family are affected, which points to a hereditary disposition. Some think chronic oophoritis is the cause ; others have taken chlorosis to be a factor in tiie production of ovarian cysts : the monthly congestion in these patients is insufficient to cause a men- strual disciiargo, but strong enough to produce hypertrophy of the walls of the follicle, and tiuis start the development of a cyst. Symptom.'!. — If the tumor can rise freely into the abdominal cav- ity, it may pass unnoticed until it is large enough to give the patient the appearance of being in a state of advanced pregnancy. But, as a ride, it gives rise before tiiat to diverse abnormalities. Quite commonly she complains of pain in one or both sides of the pelvis or the sacral region. In some patients each menstruation is DISEASES OF THE OVARIES. 623 accompanied by pain, fever, and increase in size of the tumor, which symptoms are doubtless due to congestion. Sometimes the pain occurs regularly about a week after menstruation as a kind of intermenstrual pain (p. 429). As a rule, the patient has an abnormal sensation in walking, sitting down, or rising. Often she complains of cold feet, probably due to an imperfect circulation. In the beginning there are no menstrual disturbances ; but, when the tumor becomes large, it is often accompanied by meuorrhagia, especially if it is intraligamentous ; and still later, wlien all ovarian tissue has disappeared, menstruation often ceases altogether. On the other hand, even after the menopause new hemorrhagic discharges from the uterus may occur. Even if menstruation takes place, and only one ovary is affected, the patients are often sterile, which may be due to the diminished number of ovules, a more difficult ovulation, inflammatory deposits, tubal disease, the displacement of the uterus, or endometritis. On the other hand, women with two large ovarian cysts may yet occa- sionally become impregnated, but their preguancy is often cut short by abortion. Like other abdominal tumors, and, on account of the enormous size they sometimes attain, in a higher degree than most others, ovarian tumors give rise to a series of symptoms, all of which are referable to i)ressure. If the tumor is prevente<l by intraligamentous development, adhe- sions, or shortness of tiie pedicle from rising up into the abdominal cavity, symptoms of this class begin as soon as the tumor reaches the size of a fetal iiead. If, on the other hand, it leaves the pelvis, they come much later. Pressure on the bladder causes frerpient micturi- tion ; that on the rectum, constipation. Moderate compression of the ureters leads to a scanty excretion of urine. If one of them becomes closed, the urine; a('(;umulates above the stricture and in the jielvis of the corrcspouding kidney, eausing hydroucphrosis and uremia ; but sometimes the organism adapts itself to the new relations, and secre- tion ceases in the <'orresj)onding kidixy, the pressure from below being greater than that in the interior of the kidney.^ I'ressure on the hemorrhoidal veins or on the trunks to which they carry the blood — the internal iliac and the superior mesenteric — is conducive to the formation of hemorrhoids. The pressure on the internal iliac veins and the vena cava inferior may becotne so great that these chan- nels |)ractieally become impervious. Under such circumstances tin; blood finds an outlet through the deep and the su|)erfici;il ej)igastric veins, the roots of which anastomose with those of the internal mani- '.I. W. Hovc^c, " rrctero-iirctrnil Anastomosis." /In7i. o/A'j/n/., .Jan., 1S97, reprint, p. '2-"), referring to .James, I'liy.^iohnjirdl imtl Clinirnl Study, Kdinlmrgli, 1S88, p. 41). 624 DISEASES OF WOMEN. mary vein ; but, as a result of the increase of the blood carried, the veins on the lower part of the abdomen become much enlarged. The uterus is pushed over to tiie opposite side by a lateral cyst. If both ovaries are cystic, they push the uterus forward. In the begin- ning the uterus lies, as a rule, in front of the ovarian cyst, but later behind it. The pressure may become so great that it becomes pro- lapsed. Pressure on the stomach is accompanied by nausea, vomiting, and anorexia. The liver may become flattened, and in rare cases jaundice appears as a sign of compression of this organ or the excretory ducts destined to convey the bile to the intestine. Tlie apex of the heart may be pressed outward and upward, so that the whole organ occu- pies a more horizontal position. Even the substance of the heart is apt to undergo fatty degener- ation or brown induration, which may become a cause of sudden death. The compression of the lungs gives rise to rapid and super- ficial respiration. In rare cases a serous exudation takes place into the cavity of the pleura. Even the lower ribs and the ensiform process may be turned outward. Interference \vitli the free circulation in the femoral and ex- ternal iliac veins causes varicosities and edema of the legs and labia majora, which are still more increased, when the stagnation results in the formation of a thrombus in those large venous trunks. Rarely neuralgia appears in the legs in consequence of pressure on the sacral plexus or the large trunks innervating the lower extremities. Some- times a certain variability is observed in the pressure-symptoms. They increase during congestion of the tumor and diminish in conse- quence of profuse menstruation, diarrhea, and abundant diuresis. In some cases a blowing sound may be heard with the stethoscope on the abdomen, like the uterine souffle of pregnancy. It is probably due to compression of the large blood-vessels of the pelvis. The abdominal wall becomes thin, the umbilicus protrudes, and the skin is the seat of strijc, due to rupture of the corium. This tension of the skin may be accom])anied by painful burning and exasperating itch- ing, which disturb the sleep of the patient. A symptom that often is the first to bring the patient to the phy- sician is the increase in size of the abdomen. Sometimes she can distinctly tell that the swelling has begun in one iliac fossa ; and, per- haps, we can yet feel it there ourselves; but when the tumor grows large, it becomes central and fills the abdomen. The rapidity with which it grows varies much. The glandular variety grows fastest of all, and becomes largest ; the papillary grows more slowly, and does not acquire such large proportions; the paucilocular dropsy of the Graafian follicles and a monocystic dermoid cyst develop most slowly and remain smallest of all. DISEASES OF THE OVARIES. 625 The larojer the tumor becomes, the more the patient leans backward in order to move the center of gravity into a more favorable position, just as a pregnant woman does. When the growth becomes too heavy and unwieldy, she cannot Avalk at all. She cannot even lie on her back, but only on the side, and can only turn with the assistance of others. In the beginning the general health is good, but soon the patient begins to lose flesh and strength. Digestion, respiration, circulation, innervation, all suifer. Sleep is often disturbed. Pain, anxiety, and loss of adipose tissue give her face a pe<;uliar expression, the so-called fades ovariana (Fig. 347), characterized by pinched features and deep- ening furrows. Fig. 347. Facies ovariana (SpeuctT Wells). In rare cases the breasts may undergo a development similar to that of pregnancy. Sometimes aphthous stomatitis develops toward the end. As a rule, the disease ends fatally, and many are the ways in which death is incurrcKl. It may be due to lack of nutrition, dyspnoea, hydrothorax, pleurisy, pneumonia, insomnia, exhaustion, heart-dis- ease, hydroMcpiirosis, nephritis, uremia, hemorrhages into the cyst, inflammation and suppuration of the; cyst, rupture into the jx'ritoneal cavity, twisting of the pedicle, acute or chronic peritonitis, cancerous degeneration, etc. By physic.il examinati<tn the presence; of a tumor is made out. If the patient is nervous and contracts her abdominal muscles, it may be neeessjiry to anesthetize her (|). lOo), and certain details in regard to the j)edicle can only be a^^certained in this condition. 40 626 DISEASES OF WOMEN. A complete examination is to be made both of the pelvis and the abdomen (pp. 141, 160, cf i>e(j.). By bimanual examination (p. 143) we may find the womb dis- placed, as described above in spealving of pressure, or we may find the vagina elongated by being pulled up by the tumor and ending as a funnel-shaped canal, the vaginal portion of the uterus having dis- appeared. If the tumor is confined to the pelvis, we will feel it as a globular elastic mass to one side of or behind the uterus. As a rule, the tension of the cyst is too great to allow fluctuation to be felt. Even when the tumor is developed in the broad ligament, close up to the edge of the uterus, a shallow furrow between the two indicates the line of demarkation. In cases of large tumors part of the cyst may be felt in the pelvis. The independence of the uterus is also made out by introducing a sound and moving the uterus. The cavity of the uterus is often somewhat deeper than normal. Often a larger part of the tumor may be felt through the rectum than through the vagina. Some- times external papillomata may be felt through the rectum or the vaginal roof. If the tumor extends into the abdomen, we notice by ins})ection that the abdomen is more prominent than usual. By palpation we feel the resistance offered by the tumor, judge of the mobility or im- mobility of the same, and in most cases feel fluctuation. "SVe fold the abdominal wall in front of the tumor, and move it in different direc- tions, and move the tumor from side to side and up and down. In order to feel the pedicle, one assistant pulls the uterus down with a volsella, another lifts the tumor, and the surgeon tries to feel the hard string extending from one to the other. In palpating an ovarian tumor we sometimes hear and feel a super- ficial crepitation, which is explained in different ways. I believe it to originate in fresh adhesions between the tumor and the abdominal wall, as I have noticed almost identically the same sensation in peel- ing off the nienil)ranes from the inside of the uterus in performing Cesarean section. Percussion elicits a dull sound over the tumor, surrounded on both sides and above by an area of tympanitic resonance due to the intestine. Auscultation permits us sometimes to hear a blowing sound in enlarged and partially compressed blood-vessels. The following measures should be taken with a tape measure : the circumference at the level of the umbilicus and at the most prom- inent point, if that measure differs from the first ; the distance from the symphysis to the umbilicus and from the umbilicus to the ensi- form process, and to both anterior superior spines of the ilium. In DISEASES OF THE OVARIES 627 tumors of moderate size the distance from the symphysis to the umbilicus is longer than from the latter to the ensiform process, and the distance from the umbilicus to the anterior superior spine of the ilium is greater on that side where the tumor is situated. In very large tumors these differences disappear. In the course of the development of ovarian cysts some accidents may occur, the clinical asp^'ts of which would require special attention — namely, hemorrhage, inflammation, suppuration, twisting of the pedicle, ruj)ture, ascites, peritonitis, and intestinal obstruction. Hemorrhage. — Small amounts of blood are frequently mixed with the cystic fluid without giving rise to any symptoms, but if the intra- cystic bleeding is considerable, it may even jeopardize the patient's life. This occurrence is marked by a sudden increase in the size of tiie tumor, a weak ])ulse, dyspnoea, fainting, pallor, and a cold, clammy skin. While a moderate bleeding may, perhaps, be arrested by means of an ice-bag placed on the abdomen, signs of serious internal hemor- rhage call for inmiediate ovariotomy. Inflammation and Suppuration. — The cyst may become inflamed, which is accom])anied by fever, pain, and tenderness of the tumor. If the inflammation passes into suppuration, the patient is seized with more or less regularly recurring rigors, followed by profuse perspira- tion and high temperature. Simple inflammation is treated success- fully with ice-bags, while suppuration is an indication for immediate removal of the cyst. Torsion of the Pedicle. — If torsion takes place very slowly, it may develop without appreciable symptoms, except a gradual diminution of the tumor, but if it (Xicui's suddenly, it is accompanied by ra])id enlargement of the cyst, pain, tenderness, incessant vomiting, the vomit soon becoming green in color, and acceleration of the pulse. The torsion may be temporary. AVith its cessation the symptoms stop. If it continues, it may lead to ascites, internal hemorrhage, rupture of the cyst, suj)puration, peritonitis, or gangrene of the tumor. I?ut it may also follow a more chronic course, and end the j)atient's life by slow infe(;tion and marasiiuis. If the diagnosis of toi'sion of the j)e<licle can be made, ovariotomy should i)e performed at once. Wy means of artificial prola})se of the uterus (p. 145) the torsion may be directly felt. Rupftire of thr Ci/sf. — Rupture into th(> peritoneal cavity of small cysts with serous contents need not produce any symptoms. If the cyst is lai'ge and the eontcMits watery, the fluid is soon absorbed and dispose<l of by increased diuresis and pei-spiration. Colloid fluid may remain for months in the peritoneal ("avity. The ruj)ture of a cyst with bloody contents may be followed by the development of a retro-uterine hematocele. If pus or other irritiint fluid is poured into the ])eritoneal cavity. 628 DISEASES OF WOMEN. it sets up general peritonitis. Smaller amounts .of fluid may, how- ever, only cause local peritonitis and adhesions. If a large cyst ruptures into the peritoneal cavity, the patient has a sensation of something giving way, is seized with sudden severe pain and faintness. The surgeon can feel the fluid move freely in the peritoneal cavity. In rare cases a new large tumor may form in the peritoneal cavity (p. 620). In some cases rupture occurs repeatedly, each time accompanied by temporary diminution of the cyst and symptoms of peritonitis. The effects of rupture being so very different, the appropriate treatment must be decided on in each case according to circumstances. If the symptoms are at all alarming, ovariotomy should be per- formed at once. The rupture into the stomach is marked by vomiting of cystic fluid. That into the intestine is evidenced by evacuation of the fluid through the anus, and diarrhoea. When rupture takes place into the bladder, cystic fluid, hairs, and teeth may be evacuated with the urine. If the cyst ruptures into the vagina, the contents are evacuated through the vulva. The evacuation through a hollow organ or through the skin, like that into the peritoneal cavity, may be intermittent. If the com- munication has taken place with the intestine, no infection need take place, the opening being small and valvular, or being kept temporarily closed by the inside of the cyst-wall applying itself against it. The rupture through a hollow organ may effect a spontaneous cure. It is, therefore, wise to await developments before undertaking any dangerous operation. Ascites. — Serous fluid may accumulate in the peritoneal cavity, outside of the tumor, in consequence of chronic peritonitis, torsion of the pedicle, rupture of the cyst, hydronephrosis, and, perhaps, pressure on the vena porta. Papillary cystomas are particularly apt to be surrounded by ascitic fluid. A moderate amount of such fluid may be looked upon as bene- ficial, as it prevents the formation of adhesions, and, therefore, fiicili- tates the removal of the tumor. A large collection increases, of course, the gravity of all the pressure-symptoms. Peritonitis. — Local or general peritonitis, characterized by the usual symptoms, — fever, vomiting, pain in the abdomen, great tender- ness, exudation, and tympanites, — is a very common accompaniment of ovarian cysts. It may be caused by friction, torsion of the ])edi- cle, or rupture of the cyst. It leads to the formation of adhesions which render the removal of the cyst more difficult or impossible. As a rule, its occurrence should, therefore, be met by immediate ovariotomy. Intestinal Obstruction. — As the result of pressure of a large tumor DISEASES OF THE OVARIES. 629 on the intestine, or the formation of adhesive bands, or the torsion of the pedicle, involving the intestine in its convolutions, the latter may become impervious — an accident characterized by the usual symptoms, constipation, gaseous distention, pain, and vomiting, which finally becomes stercoraceous. This grave condition calls for immediate ovariotomy. Explorative Puncture. — The practice of withdrawing some fluid from the tumor by thrusting the needle of an aspirator through the ab- dominal wall, which in most cases gave valuable information about the nature of the tumor, has practically been abandoned. The reasons of this change are that a blood-vessel might be wounded ; or cystic fluid find its way into the peritoneal cavity, and cause peritonitis or metastases, especially in case of a papillary cystoma ; or suppuration be brought on in the cyst, which, however, can be avoided by using an aseptic syringe and disinfecting the skin ; or adhesion be caused between the cyst and the wall. I believe, however, that the chief explanation is to be found in the development of abdominal surgery : while twenty-five years ago most surgeons avoided operating on other tumors than ovarian cysts, they are now prepared to attack whatever they may find after opening the abdomen. Aspiration through the vagina is yet frequently used in different pelvic disorders, and thus familiarity with the fluid of ovarian cysts is still of importance, both for diagnostic and curative purposes. Diagnostic Value of the Examination of the Fluid. — By studying the physical, chemical, and microscopical characters of the fluid, it is almost always possible to diagnosticate ovarian cysts from others. Myxoid ovarian fluid has in most cases a certain ap})carance by which it can be recognizal at once simply by looking at it. Viscidity is the most important ])hysical character when present, but it may exceptionally be wanting in ovarian and present in non- ovarian fluid. No chemical prmluct peculiar to ovarian cysts has been found. As a rule, the fluid of an ovarian cyst does not coagulate sjwnta- neously, and, wiien it does, tiie coagulation takes place slowly. As- citic fluid, as a rule, coagulates spontaneously and slowly, forming a small coaguhiin. The fluid of uterine fibrcxysts sometimes coagu- lates, and then immediately after Ijeing evacuated and en max.se. Ovarian fluid, as a rule, coagulates to a great extent or entirely by heat. That of the cysts of the broad ligament does not coagidate by heat, unless an acid is added. There is no j)atliognomonic morj)hological (element in ovarian fluid. The most imj)ortant (ilement in regard to diagnosis is colunniar ('j)i- thelial cells se(;n in sich; vi(!W. Tlicir presence exchides all other tumors than those of the ovary, the Fallo|)ian tube, and tiie broad liganjent (perhaps with the exception of the rare pancreas-cysts). 630 DISEASES OF WOMEN. Although the small granular bodies described above, and repre- sented in Fig. 338, may be found in very different fluids, the pres- ence of many of them in an abdominal cyst is a strong presumption in favor of its ovarian origin. If a cystic fluid contains hair or epidermis-cells or is composed of fluid fat, it comes from a dermoid cyst ; but we can only conclude that it is ovarian, if besides it contains the just-mentioned form- elements. A fluid as clear as spring-water and containing veiy few histolog- ical elements may be found in ovarian cysts, both in true monocysts (hydrops folliculi) and in multilocular cysts with ciliated epithelium. Both ovarian cysts and cysts of the broad ligament may have serous or colloid contents, but the latter is common in ovarian cysts, rare in extra-ovarian, while a watery fluid is common in extra-ovarian, rare in ovarian cysts. Besides the information gained by the examination of the abstracted fluid, explorative puncture offers the advantage that many relations of a cyst, which were masked as long as it was full, may be felt after it is emptied. As to the modus operandi, see p. 169. Explorative Incision. — If the symptoms and signs of an abdominal tumor yet leave the surgeon in doubt as to its being ovarian or as to the possibility of its removal, resort should be had to explorative laparotomy (p. 170). Differential Diagnosis. — The diagnosis of abdominal tumors is often so difficult, and so many mistakes have been made, that an operator before coming to a final conclusion, and especially before beginning an operation, should bear in mind the mistakes that have been recorded and the means of avoiding them. It is convenient to consider separately the diagnosis as long as the tumor is confined to the pelvis, and when it has become abdominal. A. Pehic Tumor. An ovarian tumor in the pelvis should be differentiated from 1, cellulitis; 2, peritonitis; 3, hydro- and pyosalpinx ; 4, a cyst of the broad ligament ; 5, hematoma of the broad ligament ; 6, a retroflexed gravid uterus ; 7, extra-uterine pregnancy ; 8, retro-uterine hemato- cele ; 9, fibroid and fibrocystic tumor of uterus ; and 10, solid ovarian tumors. 1. Cellulitis gives the history of inflammation, and as a probable cause, labor or abortion. The swelling is hard unless an abscess has formed, when it is softer than a cyst. It is immovable. The limits are less distinct. 2. Peritonitis gives a history of inflammation, and is generally caused by the use of the sound, some operation performed on the DISEASES OF THE VARIES. 631 utenis, or gonorrheal infection. It is often combined with endo- metritis and salpingitis. The swelling is immovable. The fluid is serous, never viscid or ropy, and does not contain columnar epithelial cells. 3. Hydro- and Pyosalpinx are usually bilateral, and form long sausage-shaped tumors. 4. Cysts of the broad ligament have very distinct fluctuation, are less tender, and contain, as a rule, a fluid tiiat is thin, colorless, and does not coagulate by heat before the addition of an acid. 5. Hematoma of the broad ligament appears suddenly, is accom- panied by pallor and fainting, and is soon reabsorbed. 6. The retrqflexed gravid uterus is accompanied by signs of preg- nancy, and often constipation and retention of urine. The mass in Douglas's pouch is continuous with the cervix, and can often be replaced. 7. Extra-uterine pregnancy gives the signs of pregnancy. A tumor is felt either independent of the uterus or attached to it. The patient has attacks of sudden, violent ])elvic pain. Sometimes there is a bloody discharge from the uterus containing decidual shreds. 8. Retro-uterine Iiematocele gives a history of sudden abdominal pain at a menstrual period or of menorrhagia, followed by inflamma- tion. The tuMKjr, at first very soft, soon becomes hard. 9. Fibroids of the xderus are hard, situated in the uterus or inti- mately connected with it. The uterus has an irregular shape. Hard nodules are often feU. Fibrocystic tumors may be fluctuating, but form one mass with the uterus, and hard nodular masses are likely to l)e felt. 10. So/ id ovarian tumors are nmeii rarer than (ysts, are hard, often nodular, frecjuently accompanied by ascites, the fluid of which may, if the tumor is cancerous, contiiin large round or pear-shaped cells, isohited or in groups, and witli single large nuclei. B. Abdominal Tumor. If the ovarian tumor has risen into the abdominal cavity, it should be differentiated from the; foHowing swellings: 1, pregnancy (normal, with excess of iicpjor amnii, with dead child, or extra-uterine); 2, hy- datiform mole; 3, hematometra, hydrometra or j)hysonietra ; 4, fibroid or fibrocystic tumor of the uterus; o, ascites ; (5, hcniatocele ; 7, eiuysted peritonitic exudation ; 8, tui)erculosis of the j)eritoneum ; !), cancer of tiie p(;ritoneiiui ; 10, a cyst of the broad ligament ; 11, an omental (yst or solid tumor; I 2, hydronephrosis ; 1 .'>, a renal (yst ; 14, a floating kidiujy ; 1"), a hydatid; IG, a liver-(yst ; 17, a floating liver; 18, a pancreits-(yst ; 19, a (yst or solid tumor of" the spleen; 20, a (yst C'i2 DISEASES OF WOMEN. of the mesentery ; 21, a cyst of the abdominal wall ; 22, a solid tumor or swelling of the abdominal wall ; 23, hydrosalpinx ; 24, spina bifida ; 25, dilatation of the stomach ; 2G, a distended bladder ; 27, impacted feces; 28, tympanites; and 29, a phantom tumor. 1. Pregnancy is characterized by numerous signs, especially the fetal heart-sound, fetal movements to be heard and felt, parts of the fetus to be felt by vaginal or abdominal examination, ballottement, purple color of the vagina, and softening of the cervix and lower uterine segment. The tumor forms one mass with the cervix and is con- tractile. In hydramnion the fetal heart-sounds may be inaudible and the fetal parts may be difficult to feel, but we have the history and other signs of pregnancy, unusual distention of the lower uterine segment, and sometimes an open cervix, allowing the examiner to place the finger right on the ovum. Amniotic fluid differs from all others by containing large flat cells filled with fat, and free masses of fat. If the child is dead, we have, of course, no fetal sounds or move- ments; but the history and other signs of pregnancy remain, and the fetus can be felt. Extra-uterine pregnancy rarely advances so far as to form a large abdominal tumor. We have the history and the signs, not only of pregnancy, but of ectopic gestation (p. 631), and the fetus is even felt more easily than in intra-uterine pregnancy. 2. A hydatiform mole may be very like an ovarian cyst, but it differs from it by the condition of the cervix during pregnancy, the contractility of the uterus, and the discharge of a bloody fluid con- taining ddbris of the vesicles of the chorion. 3. Hennatometra, hydrometra and physometra (p. 441) are all sit- uated in the uterus, follow atresia of the genital canal, give rise to menstrual molimina, and do not affect the constitution. 4. Sessile fibroids are hard, nodular, and situated in the wall of the uterus. Pediculated fibroids may be much like an ovarian cyst, but are harder. Fibrocystic tumors of the uterus may be so like multilocular, colloid, sessile ovarian cysts that the most experienced gynecologists may be deceived in differentiating them. The points to keej) in mind are that fibrocysts are rare, that they usually appear in persons over thirty years of age, that the uterine cavity commonly is considerably enlarged, that the tumor, as a rule, forms one mass with the uterus, that its consistency is harder, that hard masses are often felt in the up])er part of the tumor, that the patient often suffers from profuse menorrhagia, that the development is slow, and that the constitution suffers less. If the fluid coagulates sj)ontaneoHsly, rapidly, and in toto, it is proof that the tumor is a fibrocyst. DISEASES OF THE OVARIES. 633 5. Ascites. — The abdomen appeal's flat, and no tumor is felt. The fluctuation is very marked. The percussion is tympanitic on the part of the abdomen turned upward, and dull in the dependent parts in whatever position we place the patient. In Fig. 348 the shaded Fig. 348. Percussion-sound in Ascites to the left and in Ovarian Cyst to the right when the patient lies on her baclc (Spencer Wells). parts mark the dull percuasion. The fluid is not viscid, forms a small coagulum by exposure to the air, and contains flat endothelial cells and lymph-corpuscles with ameboid movements. .Vs a rule, the condition is found to be due to di.seases of the liver, heart or kidneys. If the ascitic collection is so enormous as to distend the whole abdomen, it may, however, be impo.ssible to elicit the above-described signs ; but then such a mass of fluid may accumulate in the course of a few months in ascites, while an ovarian cyst takes years to gi'ow to such enormous proportions. The uterus is easily movable in ascites, immovable in cases of very large cysts. 6. Hematocele (see al)ove under Pelvic Tumor). 7. EnnjHted perifonitic ej-udation gives a history of inflammation. The fluid is serous, like that in a.scites. 8. Tiihcreu/osis of the peritoneum is accom])anied by free fluid, and often i)y a tumor formed by agglutinated intestinal knuckles and omentum, that may be hard to diflcrentiate from an ovarian tyst. These jiseudotiunors, howeviM", are much more common in voung women than later in life, and grow much more rapidly than ovarian cysts. iSometimes the central part of the abdominal wall is the seat of a red blush and edema. The fluid is straw-colored, and coagulates, at least partially, by exposure to the air. The presence of tul)ercl(>s in the lungs, pleurisy, gn'at tenderness, on pr(>ssure, of the intestines, and a rise in temperature in the evening, also go far to establish the diagno- 634 DISEASES OF WOMEN. sis of tuberculosis of the peritoneum ; and as laparotomy has proved a cure for this disejise, no harm is done, if a mistake should be made.^ 9. Caticer of the peritoiwuia is accompanied by rapid cachexia. The fluid often contains characteristic cells (p. 540). Large, hard, irregular masses can be felt in the abdominal cavity. 10. Cysts of the broad ligament are much rarer than ovarian cysts, seldom larger than an adult's head, immovable, and dip deep into the j)elvis, where they are situated close up to the uterus. As a rule, they develop slowly. Tlie fluid is as described above under Pelvic Tumor. AVhen evacuated, the tumor is slow to refill. 11. Omental cysts are situated higher up in the abdomen, and have no connection with the pelvic organs. The fluid is serous like that of ascites. ' There may also be a solid tumor of the omentum, especially a carci- nomatous tumor. 12. Hydronephrosis lies behind the intestine, and occupies a more lateral position. There is a history of urinary trouble. The fluid may contain columnar epithelial cells and a large amount of urea, but these features are very unreliable, and even deceptive. Perhaps it may be reached by means of catheterization of the ureter (p. 165). 13. Renal cysts are rare. There is a tympanitic percussion-sound, because the intestine lies in front of it. There is a history of urinary trouble. These cysts develop from above downward. Sometimes the peculiar shape of the kidney can be recognized. The fluid con- tains much urea. 14. A floating kidney or one fastened in the iliac fossa has also been mistaken for an ovarian cyst. In this case the characteristic shape is still better preserved than when the organ is the seat of cystic degeneration. 15. A hydatid of the liver develops downward from the right hypo- chondrium, and can be felt to be continuous with tlie liver. The dull percussion-sound extends uninterruptedly to the liver region. Some- times hydatid vibration can be felt. The fluid is clear as spring- Avater, does not coagulate by heat, and may contain booklets of echi- nococci or shreds of cuticula, the parallel striation of which is pathog- nomonic. In its chemical composition enter succinic acid, leucin, grape-sugar, and inosite, but never paralbumin. [Hydatids of the Pelvis will be described in Part vii.. Chap. ix). 16. Liver-cysts, other than hydatid cysts, are exceedingly rare. They develop from the right hypochondrium. The fluid may con- tain bile or liver-cells, and does not contain the bodies usually found in ovarian tumors. 17. A floating liver is recognized by its shape, the clear percussion ' Encysted tubercular peritonitis has been lucidly discussed by W. T. Howard of Baltimore in Trans. Amer. Gyn. Soc, 1885, vol. x. pp. 41-62. DISEASES OF THE OVARIES. 635 in the liver region, and the possibility of replacing the liver in its normal position. 18. Pancreas-cysts are rare and develop downward. The fluid is acid and contains small nuclei and peculiar thready bodies.^ 19. Cysts of the spleen are very rare, develop from the left hypo- chondrium, and the fluid is rich in leucocytes. Solid splenic tumors retain the peculiar shape of the spleen, and are harder. All tumors coming from above leave for a time a resonant space above the symphysis. The production of gas in the stomach and in- jection of water into the intestine drive a tumor in the direction from which it has started (p. 160). 20. Q/.s'fe of the rnesentertj are very rare. Perhaps both ovaries can be felt. The tumor is sometimes freely movable in an upward direc- tion. A kind of pedicle formed by tiie mesentery may extend to it from above. The fluid is serous, without epithelial cells. 21. Cysts of the abdominal wall have no connection with the uterus. The fluid is serous, and does not contain cellular elements. Cysbi of the nrachus contain flat ej)ithelial cells. 22. .1 solid tumor of tlie abdominal wall, especially a fibroma of the transversalis fascia with partial cystic degeneration, has been taken for an ovarian cyst." The lack of menstrual disturbance and of pain may give rise to a doubt, which may be cleared by examina- tion under ether. A thick layer of subcutaneous adipose tissue has given rise to tlie same mistake, but it may be raised between the fingei-s, and on deep percussion we get a clear sound. Edema of the anterior wall is characterized by the pitting left by pressure. 23. Hydrosalpinx very seldom forms a large tumor (p. 575). It is, as a rule, bilateral, always monocystic, and not very tender, Tlie fluid is serous, and does not contain tlie bodies coinmonlv found in ovarian tumors. Tlie presence of ciliated columnar ei)ithclial cells does not decide the (piestion (p. 614). 24. Spina bifida very rarely forms a tumor in the jK'lvis and abdo- men, i)ut in one case it contained some three (juarts of fluid.^ This is watery, colorless, limpid, without form-elcmciits, and contains only traces of albumin. Alt<'r evacuation of the fluid the fissiu-e in the sacrum through which the cyst entered the jxilvis may be felt. 25. Dilatation of flic Stomacli. — Tnci'edible as it mav seem, even a dilated stomach has been mi>lak('n for an ovarian cyst and <)j)erate(l ' fJarrigiK's, Ditif/nfiKln, p. 8G. * An intiTcstiiiK case of tlie kind wjts reported bv Kob. Weir, in llu! Med. Record, Dec. n, 18.S7, xxxiii. TO.".. ' Kinmel, (iipircolo</ij, 2d ed. p. 791. C36 DISEASES OF WOMEN. on.^ The chief points which are to be borue in mind in order to avoid a similar mistake are the great variations in the size of the tumor; the change in the distribution of the tympanitic and the dull percussion-sound, according to the presence of gas or food in the stomach ; and the large quantities of food vomited at times, rep- resenting nearly all that has been ingested for several days. Once on the alert, the diagnosis can be made clear by the introduction of an esophageal sound or the production of gas in the stomach (p. 160). 26. Distention of the Bladder. — A bladder may be overdistended with urine although the patient urinates {ischuria paradoxa), and may form a very large tumor in the abdomen.^ Before making his examination the doctor should, therefore, introduce the catheter, and empty the bladder. 27. Impaction of Feces. — A patient may likewise suffer from diar- rhea, and still carry large masses of feces in her intestines, which may be mistaken for tumors. Before a diagnosis is made, the bowels should be emptied with aperient medicines and large irritating enemas (p. 178). 28. Tympanites gives tympanitic percussion-sound. 29. A phantom tumor is a curious condition sometimes met with in hysterical patients and in those affected with caries of the vertebrte. Through a combination of adipose tissue in the wall and tetanic con- traction of the abdominal muscles a protuberance is formed on the abdomen, which even may give a somewhat dull percussion-sound. The moment the patient is anesthetized the supposititious tumor sub- sides and disappears, leaving an area yielding the normal tympanitic sound of the intestine. Large extraperitoneal ovarian cysts are particularly difficult to diagnosticate. They have no pedicle. Other signs, that, taken conjointly and not singly, may give rise to a more or less strong suspicion of the existence of this kind of cyst, are the following : 1, close adherence to the enlarged and laterally displaced uterus ; 2, elongation of the bladder, as proved by the introduction of a steel sound ; 3, pressure on the rectum and bulging out of the posterior vaginal cul-de-sac; 4, embarrassed defecation and micturition; 5, spontaneous rupture of the cyst; 6, unusual ])ain caused by the growing cyst; 7, tympanitic percussion-sound in front of the tumor, like that found in renal tumors; 8, an unsynnnctrical shape and preponderating development in one side of the pelvis of a firmly fixed cyst.^ Complications. — Ovarian cysts may be complicated by many dis- eases, some of which may be directly referable to the pressure ^ Reeves Jackson, Detroit Lancet, 1880 ; Cevtralblatt. fdr Gyndk., 1880, vol. iv. p. 368. ^ I have myself withdrawn three quarts of iirine from the bladder. ' Wm. Goodell, Amer. Syst. of Gynecol., vol. ii. p. 830. DISEASES OF THE OVARIES. 637 exercised by the tumor itself, while others are mere coincidences, which, however, may have considerable influence on the prognosis and treatment. Thus we would not perform ovariotomy, if the cyst is accompanied by cancer of the uterus, unless the latter organ could be extirpated at the same time — an addition to the operation which, of course, would cast a deep shadow over the prognosis. In advanced tuberculosis or any other serious chronic disease it may also be deemed inadvisable to subject the patient to the risks of a capital operation, which at best will fail to prolong her life. The complication with pregnancy is of particular interest, since it is not so very rare, and may influence the treatment very much. It may occur even when both ovaries form large tumors, and so nmch the more so when only one is affected. The diagnosis is made from the history and the objective find, the presence of an ovarian tumor having been known before the patient became pregnant, or being made out in connection with the gravid uterus. When the pres- ence of one child is ascertained, the investigation must next be di- rected toward the second mass, with a view to decide whether the case is simply one of twins or of uterogestation combined with a tumor or of uterogestation combined with ectopic gestation. The simultaneous pressure of a growing uterus and an ovarian cyst will in most ca^es cause so much discomfort, or even be attended with such danger, that interference is called for. Three methods are tiien at our disposal : 1, artificial abortion or premature labor; 2, tapping of the cyst ; or, 3, ovariotomy. If possible, we would wait till the child is viable, and then induce premature labor. Tapping has given excellent results, and there is no serious objection to it, if performed by a man prepared to let ovariotomy follow if untoward se(|ucnces should develoj). Ovariotomy has been performed many times during pregnancy. The dangers of the operation are very slightly increased, but sometimes it is followed by abortion. Prognosis. — A spontaneous cure of an ovarian cyst may take place by means of slow torsion of the ])edick', followed by atrophy, fatty degeneration, or calcification. Or it may be brought on bv ruptiu-e of the (yst. The tumor may also shrivel uj) after one or more tappings. It may also become stationary and stoj) growing. But all these occurrences are so rare, that they must he left entirely out of consideration when the question of treatment is raised. A patient may live; twenty years with an ovarian (yst, but in the vast majority of ejises a speedy death awaits the woman aflected with such a tumor. Of those having a |)roliferating cystoma, GO to 70 per cent. die within thre(! years, and 10 per c(!nt. additional in the fourth year. Treatment. — Medical treattnent is of no avail, and galvanopuncture is more dangerous than ovariotomy. Noeggerath ' claims that a ' E. Noo^jrenitfi. Crnlralhl.j. (iifniilc., 1890, vol. xiv., "Report of Tontli Iiitor- national CongrcsH," p. 8CJ. 638 DISEASES OF WOMEN. yvenk faradic cmrent applied three times a week for from one-half to one hour makes a glandular proliferating ovarian tumor of small or medium size disappear in six to eight weeks, so that only small rem- nants of it remain. He uses the secondary current, the negative pole, covered with a sponge, in the vagina, the positive, in the shape of a sponge-covered plate of the size of a hand, on the abdomen. As the procedure is innocuous, it might be tried. Two kinds of treatment only are generally recognized — namely, tapping and ovariotomy ; and it may be stated from the beginning that ovariotomy should be performed whenever it is practicable. Ta2)ping. Tapping as a therapeutic measure is objectionable for several reasons. It may cause hemorrhage, a danger which, however, is con- siderably reduced by using a fine needle or trocar and canula con- nected with an aspirator. It may cause suppuration of the cyst ; but that may be entirely obviated by using a clean instrument, and disinfecting the patient's skin and the operator's hands carefully. Acrid fluid may find its way through the opening in the cyst into the peritoneal cavity, and set up peritonitis. This may also, to a great ex- tent, be prevented by emptying the opened cavity entirely ; but nobody ought to tap without being prepared to have an ovariotomy follow in case of supervening peritonitis. A malignant infection of the peri- toneum may take place, if the tumor happens to be of the papillary variety, and particles of the papillomatous growths are carried out into the peritoneal cavity on withdrawing the instrument. As nearly all ovarian cysts contain secondary cysts, these will, on removal of the pressure from the emptied compartment, only develop so much the faster. The tapping has to be repeated again and again, with ever shorter intervals, thus constituting a serious drain on the strength of the patient. The sudden evacuation of a large amount of fluid may so change the shape of the tumor that a rotation is induced, accom- panied by torsion of the pedicle (p. 618). In spite of all real and imaginary dangers connected with tapping, there are, however, circumstances under which it is perfectly proper to have recourse to it : 1. If a patient absolutely refuses to have ovariotomy performed, tapping may yet offer relief, and sometimes even prolong her life. 2. AVe have seen above (p. 637) that during pregnancy tapping has in many cases given excellent results as a palliative measure. If the physician is first called during actual labor, and the cyst oifers an obstruction to its progress, tapping is in many instances preferable to any other treatment. 3. The removal of very large tumors has been attended by sudden death on account of anemia of the brain caused by the rush of blood DISEASES OF THE OVARIES. 639 Fio. 349. to the abdominal organs at the cessation of the pressure exercised on them by the tumor. Other vital organs, such as the heart, the lungs, and the kidneys, may be so compressed by the cyst that they are not in a condition to perform their functions properly. It is, under such circumstances, a good plan to prepare the system for the radical operation by the preliminary slow evacuation of some of the fluid contained in the cyst. 4. Tapping may be indicated by the presence of an acute disease, such as pneumonia, bronchitis, typhoid fever, smallpox, etc., which makes it desirable to re- move pressure, but excludes the immediate perform- ance of ovariotomy. 5. It is also indicated in advanced chronic diseases, such as tuberculosis, Bright's disease, and cancer. 6. Finally, in the rare eases in which ovariotomy is impossible. Tapping may be performed through the abdominal wall or through the posterior vault of the vagina. It may be performed with a large trocar, such as that used for ascites, or by means of an aspirator. The former is more expeditious, and, if the fluid is thick, the only available method ; the latter is considerably safer. If a large trocar is used, it is well to prevent the possible entrance of air by having a soft-rubber tube attached to it, the other end of wiiich is kept under the surface of some fluid in the receptacle. The instrument rejire- sented in Fig. 349 offers the further advantage that, in case of obstruction of the canula, the trocar can J)e pushed forward again. 3fodiis Operandi. — The patient should lie on her back. The puncture is usually made in the median line, midway between the symphysis pubis and tlie umbilicus. With a hypodermic injection of cocaine (p. 223) the skin may be made insensible, and a small longitudinal incision, large enough to admit the trocar, be made through it, which leaves a better wound for healing than if the trocar is thrust through the skin. If an asj)irat()r is usfid, the pain is so insignificant and the opening so small that neither cocaine nor the cutaneous incision is called for. If the canula becomes bhx^ked up during the flow of the fluid, a disinfected stylet should be used to clear it without i-emoving it. Sometimes the obstruction is due to contact with the inside of the cyst-wall, and is overcome by changing the direction of the canula. It is risky to open Warren's Ovarian Trocar. 640 DISEASES OF WOMEN. more than one cyst at a time, as large blood-vessels may run in the deeper parts of the cyst. After the operation the wound is closed, the abdomen covered with a thick pad of cotton, and surrounded with a binder, so as to counteract the loss of pressure caused by the removal of the fluid. If there is any bleeding, which is very rare, a hare-lip pin may be passed deep in under the lips of the wound and surrounded by a figure-of-eight ligature. The patient should be kept in bed for four days. (For furtlier particulars see p. 191.) Tapping through the vagina is much more hazardous, and likely to give less relief, since the large compartments of a cyst are found in the alxlominal part of an ovarian cyst. If the operation is followed by suppuration, ovariotomy must be performed or the opening in the vagina and cyst enlarged by incision, so as to make room for a T-shaped soft-rubber drainage-tube, through which disinfectant fluid shotdd be injected daily, until the discharge ceases. Ovariotomy. Ovariotomy is the operation by which an ovarian tumor is re- moved from the body, while the term oophorectomy is used to desig- nate the removal of ovaries which do not exceed the normal size of the organ very much (p. 593). Indications and Contraindications. — In a general way it may be said that ovariotomy is indicated in every case of ovarian cyst, and as soon as its presence is discovered. Small tumors may be more difficult to remove because the pedicle is less developed, but, ou the other hand, there is less danger from adhesions. The patient is spared all the accidents to which such tumors are liable in the course of their development (pp. 627-629). Finally, we must take into consideration the pronounced tendency ovarian tumors have to become malignant (p. 620). Special indications for immediate operation are serious hemorrhage into the cyst, sup])uration of the cvst, torsion of the pedicle, rupture into tiie peritoneal cavity followed by alarming symptoms, and the occurrence of peritonitis or of intestinal obstruction. The age of the patient need not be taken into consideration : ova- rif)tomy has been performed with success in young children and in old women over eighty years of age. Even hemophilia is no contraindication, since the operation has been successfully performed under such circumstances. On the other hand, the surgeon should abstain from so capital an operation, if tiie patient is in an advanced stage of tuberculosis or chronic nephritis or suffers from cancer in any other organ than the ovary, unless the cancer cjm be removed at the same time or by a separate operation. Cancer in the ovarian cyst itself also forms a DISEASES OF THE OVARIES. 641 contraindication, if the disease has invaded the surroundings or in- fected tlie constitution. The same applies to any other wasting dis- ease that may be expected soon to put an end to the patient's life. Ovariotomy may be performed through the abdominal wall or through the vagina, the former of which methods is by far the more common and important. Vaginal ovariotomy should be limited to cases of small, especially freely movable cysts. The drawbacks in entering the abdomen from the vagina have been set forth in speaking of oophorectomy (p. 570), and the great frequency of adhesions of ovarian cysts recommends particularly the abdominal section for tumors that have risen into the abdomen. Small cysts behind the broad ligaments may be removed by posterior colpbtomy, but small intraligamentous cysts are best reached through anterior colpotomy (p. 475). Vaginal ovariotomy has received a new im])ulse by being combined with hysterectomy by Pean's method (p. 510). It is claimed by those who advocate this method that it is indicated (1) for tumors of the appendages reaching or even passing a little the umbilicus, whether cystic or solid, but bilateral and perfectly movable ; and (2) for tumors that are less voluminous and situated low down, whether mobile or im- pacted, complicated with ascites or not, but decidedly bilateral.^ But in the author's opinion the diagnosis is often so uncertain, and the execution of the operation often so difficult, that, while it may be true that in the hands of surgeons who have had exceptional experience in vaginal hysterectomy, that method is to be preferred, the average surgeon is likely to serve the interests of his patient better by following the abdominal route. The stress laid upon avoidance of the abdominal scar seems under such grave circum- stances to be nither misplaced, but it emphasizes tlie importance of using the greatest possil)le care in closing the abdominal wound. In tiie following exposition we consider only abdominal ovari- otomy. Prrjxirafory Treatment. — If the patient is weak, and. has been living under unfavorable circumstances as to food and shelter, it is advisal)le to give her a elianee to gain in health and strength by proper diet and regimen. Under all circumstances the skin is cleaned, the bowels are em|)tie(l, and, if necessary, the functions of the kidneys regidated (p. 205). Some surgeons give ten grains of quinine for several days, in order to ward ofl' fever; which, however, is hardlv necessary, unless the patient is subject t(i nialaria. Others giv(^ strvchiu'iic to bnice her against shock. Otiiers |)raise bromides as a preventive of voiTiiting. In regard to season, the time of the day, menstruation, laetiition, the arrangement of tlie room and table, the ])reseuce of spectiitors, ' Paul Segond, Jin-iie de (lym'col. et dr Cliir. >il,<h„nii„di\ 1897, No. 2, p. ^aH. 41 642 DISEASES OF WOMEN. the administration of the anesthetic, the patient's dress, and disin- fection, the reader is referrtnl to what has been said in speaking of operation in general (pp. 201-233). Instruments, Spongi\'<, etc. — In a simple ovariotomy very few instru- ments are required ; but as it is impossible to foretell with certainty what difficulties may arise, a rather large armamentarium must be kept in readiness to overcome them. The following paraphernalia ought to be within reach : 4 large flat sponges or half a dozen large pads ; 4 large round sponges or a dozen mediimi-sized pads ; 8 small round sponges or two dozens of small pads (p. 210; about the substitution of gauze for sponges, see p. 211) ; 4 sponge-holders (Fig. 199, p. 229) or forceps; 1 sharp-pointed bistoury ; 1 pair of knee-bent, blunt-pointed scissors ; 1 pair of blunt-pointed scissors curved on the flat ; 1 dissecting- forceps ; 1 mouse-tooth thumb-forceps ; 1 director ; 12 pairs of small pressure-forceps (Fig. 164, p. 191); 6 pairs of long pressure-forceps (Fig. 293, p. 512) ; 2 pairs of Nelaton's cyst-forceps (Fig. 352, p. 647) ; 2 volsella (Fig. 196, p. 228); 2 pairs of Spencer Wells's pedicle-forceps (Fig. 353, p. 647) ; 1 male metal catheter ; 1 female metal catheter ; 1 male urethral steel sound. No. 25 French ; 2 small tenacula (Fig. 195, p. 227); 1 Simon's sharp spoon (Fig. 133, p. 156) ; 1 tenaculum-forceps ; 1 large curved trocar (Fig. 351, p. 646); 1 small curved trocar (Fig. 175, p. 197) ; 1 aspirator (Fig. 148, p. 171) ; 2 retractors ; 1 cautery-clamp (Fig. 354, p. 648) ; 1 thermo-cautery (Fig. 161, p. 187); 1 yard of rubber cord for temporary compression ; drainage-tubes of glass and soft rubber, two of the latter T-shaped ; 1 uterine sound ; 1 dull handled needle (Fig. 202, p. 231) ; 1 Shroedor needle (Fig. 295, p. 514) ; 2 strong curved Hagedorn needles for closing incision ; 3 smaller curved needles for passing ligatures ; 3 fine curved needles ; 6 cambric needles for the intestine ; DISEASES OF THE OVARIES 643 a set of 4 iVIurphy buttons (see Appendix) ; 1 Hagedoru needle-holder; 1 common needle-holder; Silk for ligatures and sutures, fine, medium, and strong; Catgut ; Silkworm gut. A movable electric lamp is sometimes very useful ; For dressing : Iodoform ; Iodoform gauze ; Gutta-percha tissue ; Aseptic absorbent cotton ; Rubber adhesive plaster ; Flannel binder or many-tailed muslin bandage ; 6 large safety-pins. Ovariotomy begins with laparotomy. Laparotomy^ or abdominal section, is an operation consisting in an incision through the abdominal wall into the peritoneal cavity. In ovariotomy the chief steps are — 1, the abdominal incision ; 2, the removal of the cyst ; 3, the closure of the wound ; 4, the dressing. With few exceptions laparotomy is performed in the median line, between the umbilicus and the symphysis pubis. According to dif- ferent circumstances the incision is made longer or shorter, more or less near the symphysis, and may be extended beyoivd the umbilicus all the way up to tiie ensiform process. The })atient is placed on her back, extended at full length on a tiible, with her feet toward the window. The necessary preparations have been described in the general division (pp. 206-237). The operator ' Dr. Robert P. Harris of Philadelphia published in 1890 a pamplilet entitled " Oieli»to)iii/. This, (iiul nt)t l/iparotnnii/, is the proper Grrek fti/noiiipa of ' abdominal licrtioii,' laparotoini/ hfinij an iivcinion of the flank onli/." Unfortunately this name has been adopted to some extent. First, it is to l)e regretted that the euphonious word lai)arotomy, with its beautiful liquids and npen vowels, should be driven out by "celiotomy" — for that is not only the [)ronuuciation, liut the modern spelling — with its sharp siliilant and thin sound of e. Secondly, when a word has existed for nearly a hundred years, has i)assed into all languages, atul forms the root of numerous derivatives .'uid part of compound words, it cjiuses only confusion to substitute another for it. I'inally, even the argu- ment drawn from i)hiloli)gy in favor of the new word, is to say the least, doubtful. If it must be admitted that v /a:rdf>(i means the soft part between the ril)s and the crest of the iliinn, it is oidy a very slight extension to apply it to the whole abdominal wall, and it has no other sense; whereas // /<'»//« means, 1, the abdonunal cavity; 2, the stomach ; .'5, stools; 4, the pulp of the fmger ; o, any cavity ; and cousc(|uently the word o-liotomy does not convey even approximately an idea of what is going to be cut. 644 DISEASES OF WOMEN. stands ou the right side. At least one assistant besides the one who gives the anesthetic is needed, and stands on the left side of the patient, facing the operator. Many operatoi-s prefer, in order to avoid sources of infection, to have as little assistance as possible, and take the instru- ments from the tray themselves. For operations in the pelvis the elevated-pelvis position (p. 141) oifers groat advantages, the organs being more exposed to view and easier to reach. For this position the patient is turned with the head toward the ligiit. The operator may stand on her right, which affords him better light, if it comes from the side only, but has the drawback that he must lift his arm in a somewhat fatiguing way ; or he may stand on her left. Often he has to change his position from one side to the other, the principle being that, when there is any difficulty, he must stand on the opposite side to the one where he wants to see. Behind and to the left of the operator is the instrument-table ; to the right, a basin with corrosive-sublimate solution (1 : 2000), and another with plain boiled water. 1. I)icif<io)i. — In many laparotomies it suffices to make an opening large enough to admit the index- and middle fingers. If the ele- vated-pelvis position is to be used, a much larger incision is needed. In order to inspect the pelvic cavity, an incision extending from the symphysis pubis to the umbilicus is required. The first incision is made with a medium-sized scalpel through the skin, the next, after changing knife, through the subcutaneous tissue. Bleeding vessels are secured with pressure-forceps. Then the linea alba is severed. If the operator misses it and goes a little out to one of the sides, no harm is done. The only diffi^rence is that he will see and per- haps separate the inner fibers of the pyramidalis or rectus muscle. The septum between the two recti is, however, easily found by pushing a director from the opening made in the sheath to the sides, resistance being met with in tiie median line. Instead of this incision in the median line, it has been recommended to make the incision half an inch to the side of the median line, whereby it is claimed that ventral hernia is avoided.' I have tried it several times, but found adaptation of the edges less accurate than with the median incision. This can, however, be avoided by holding the nniscle aside instead of going through it, and to unite the edges of the cut aponeurosis only, without including the nuiseu- lar tissue in the suture. In tliis part of the operation there is no danger, and it may be executed rapidly, simply cutting down on the tissues. But under the muscular, fascial, and aponeurotic tissue lies a layer of adipose * Abel, Archiv fiir Gijudk., xlv. 3; Flatau, Cenlralbl. fur Qyndk., 1894, No. 12, p. 278. DISEASES OF THE OVARIES. 645 tissue, the preperitoneal fat^ which forms an important landmark, for immediately behind it is found the peritoneum. This preperitoneal fat is, therefore, best torn -with ])ressure-forceps or the handle of the scalpel, until the peritoneum itself is exposed. When the abdomen is distended by a tumor, its wall is on the stretch, and the tissues separate more easily than in other laparoto- mies, and in consequence of the j)ressure exercised on it the prejjeri- toneal fat may become very nnicli reduced. Greater care is, therefore, needed under these circumstances in making the abdominal incision than, for instance, in oophorectomy, or the operator risks ])lunging his knife right into the cyst from the stai't, not to sj)eak of Mounding organs, such as the omentum, the intestine, or the bladder, that might be in the way. The exposed peritoneum is seized with two pairs of pressure-for- ceps or with a tenaculum, and lifted uj) in a fold, in which a small opening is cautiously made with the knife. Before doing this all hemorrhage should be stopped by grasping bleeding vessels with pressure-forceps, which are left on during the following steps of the operation, until they are in the way, and bleeding has stopped. Now the left index-finger is introduced, and the knife held against it and made to cut the ])eritoneum from within outward until the hole is large enough. If after a digital ex]>loration the. operator deems it necessary to enlarge the opening, it is done with a pair of strong knee-bent scissors, one blade of which is })laced inside of the abdominal cavity, between the middle and index-fingers, which keep intestine and omentum out of the way and protect the bladder; and the other touches the skin. Thus the whole thickness of the ab- dominal wall is cut through, and bleeding vessels are caught with pressure-fi)rceps. Most such scissors, designed to follow the groove of a director, have an inner pointed blade and an outer blunt one, which does not answer our purpose. The inner blade should be the blunt one, so as not to prick the abdominal oi'gans ; on the skin there is no danger, and it is immaterial whether the blade is j)ointe(l or blunt. As to the length of the incision, it should not be longer than required, but long enough to allow of all necessary manij)ulations. A pressure-fi)rceps is put on the jieritoneum on either side of the incision, .so as to facilitate finding it when the wound is to be closed. Instead, the peritoneum may be sutured to the skin in one or more phuM's on either side. These sutures are tied loosely and left long, so that they may serve as retractors. In closing the wound they are gradually removed as they are reacluMl in inserting the perma- nent sutures. It is, however, much better to use a pair of the large cnrv(Ml side retnictors re|)resented in Fig. .'ioO. They give more room and n^fiect light into the iwlvic cavity. ' It is sometimes tailed the subperitoneal fat, an txprossion that is apt to misUad. 646 DISEASES OF WOMEN. The lower end of the incision ought, finally, to be half an inch above the symphysis ; the upper varies according to size of the mass to be removed. If the incision extends beyond the umbilicus, Fig. 350. Landauer's Laparotomy Retractor. most operators avoid this point, as being thinner and less favorable for healing, and go to the left of it. • 2. Removal of Cyst. — When the peritoneal cavity is opened the cyst appears in the wound as a pearl-gray glistening body. In order to reduce its size, the patient is turned on the side facing the operator. Emmet's trocar (Fig. 351) is pushed into it near the upper end of the Fig. 351. Emmet's Ovariotomy Trocar. incision, and the fluid directed into a tub under the table. Many operators prefer to let the patient remain on her l)ack and to use a trocar with a rubber tube attached, conducting the fluid into the vessel destined to receive it, or to have a basin covered with an aseptic towel held under the trocar. As soon as the cyst begins to collap.se it is .seized with a Nclaton forceps (Fig. 352) and pulled out. If there is much fluid, the operation is considerably expedited by withdrawing the trocar and enlarging the opening with scissors. After a little while room will be gained for the application of a sec- DISEASES OF THE OVARIES. 647 Fig. 352. ond Nelaton forceps, and sometimes even one or two volsellae may answer a good purpose in pulling out the tumor. If there are sev- eral large compartments, tiiey are opened one after the other with tro- car, scissors, or fingers, from that first entered. During the removal of the cyst the assistant compresses the abdomen, and is particularly careful to prevent the protrusion of the intes- tine. He should also, during the following steps of the operation, always keep the abdo- men closed as much as possible by approx- imating the edges, and covering the incision with a sponge or a gauze pad. If the mass of the cyst left after evacuation is still heavy or bulky, it is best to get rid of it by seizing the j)edicle in a temporary ligature of rubber tubing or strong silk, or with Spen- cer Wells's pedicle- forceps (Fig. 353), or a cautery-clamp (Fig. 354), and cutting it off at a distance of about two inches abov'e the com- pression. If, on the other hand, the cyst is collapsed and light, the pedicle is simply seized with the fingers. As described under salpingo- oopiiorectomy (p. 563), a blunt handled needle is used to carry the pedicle ligature through, and the Staffordshire knot (p. 566) may be used; but in ovariotomy it is more convenient Naatons Cyst-f(m>eps : a, to cut the pedicle-silk in two halves, cross cir^'i'ir jaws with holes .1 111," Tin ^^'^ P*^SS ; B, catcli. them, and tie each half separately, thus form- ing two links of a chain perforating and surrounding the pedicle. Fig. 353. Spencer Wells".s redicle-Rirceps. As the stum]) of the Fallopian tube might su])purate, it ought to be tied as close up to the uterus as convenient. W'lien the pedicle 648 DISEASES OF WOMEN. lias been tied, it is cut three-quarters of an inch above the ligature, and trt>ated just as the stump in salpingo-ooj)horectoniy. Finally, it is dropped, the intestine kept back, and the omentum spread over it. Fig. 354. Smith's Cautery -Clamp. Some draw the peritoneum together over the stump and close it with a continuous suture of catgut, expecting thereby to ward off infection and adhesions to the intestine ; but the first may just as Avell take place through the peritoneal covering, and, since the peritoneal endothelium must be handled in stitching, it is just as liable, or per- haps more liable, to form adhesions than the raw surface dusted with a powder like iodoform or aristol. Others sear the stump over the ligature, which is a good means of preventing absorption and adhesion, but which shortens the stump and invites the risk of burning the ligature, unless a cautery-clamp is use<^l. On the other hand, it is a double assurance against hemorrhage to seize large arteries in tiie stump and tie them separately. The distal end of the stump does not slough, because new capil- laries are speedily formed around the ligature, which convey nour- ishment enough to the part beyond. The silk becomes encapsulated, and is slowly absorbed ; but it has been found as late as two years after it had been put in. If aseptic, Fig. 355. Noyes's Alligator-forceps. it is innocuous ; but often a secondary infection takes place and a fistulous tract is formed, which will not clo.se till the ligature is ex- DISEASES OF THE OVARIES. 649 pelled or withdrawn. This is done best with the alligator-forceps of the otologists (Fig. 355), which takes up little room and has a good grip. It is better to use catgut ; but as this material is likely to become loose at the knot, particular care should be taken in tying it. AVhere larger masses are tied, as in a pedicle, a triple knot is required. After having dropj)cd the pedicle, the second ovary should be brought into view and examined. In a young woman it ought to be saved if possible. If it is healthy, notiiing is done to it. If it only shows a few small serous cysts, they should be pricked open. A larger cyst may be cut out and the edges united with a continuous catgut suture. In women who have passed the climacteric or are near that period it is safer to remove the second set of appendages, so as to prevent the formation of a cyst on this side. The same rule aj)plies, if the cyst is cancerous, as experience has shown that in such cases the second ovary is predisposed to become affected in the same way. It should also be removed, if the uterus is the seat of a fibroid (p. 494) or if for any other reason it is advisable to hasten the menopause. If no blood or other fluid has escaped into the peritoneal cavity, no attempt should be made to clean it, but the wound should simply be closed when the rest of the operation is finished. A separate nurse should have care of sponges and gauze ])ads, and before the ojjcrator proceeds to the closure of the wound the s})onges, pads, and artery-forceps should be counted, as it has ha])})ened that such obje(!ts have been left in the abdominal cavity, from which place they often have l)eeu removed after a longtime, and after much injury had been caused. Another precaution is to liave a cord attached to a corner of each of the large pads which are packed into the ab- dominal cavity to cover intestinal knuckles, etc., and to leave the ends of the cords outside the wound. 8. Closure of the Abdominal IncLnon. — ]>efore closing the abdomen, the omentum sJiould be drawn down over tiie intestines. Great care should ho taken to unite tiie dilferent layers, and especially the fascial and aponeurotic structures, as otherwise a ventral hernia is very apt to form. The best practice is first to (^lose the pi^ritoncum with a contimums suture of thin catgut. The second row of su- tures should unite the aponeurotic structures. This may i)e done with interrupted sutures or a rumiing sutures of strong catgut. A particularly sf)lid union may be obtainecl by using the cobbler's stitch, inserting a stitch for every (piarter of an inch with a curved hainlled neeclle, which is unthreadecl and tlire:i(le<l again with the other end of the thread for every stitch, so that the two ends pass through the same hoh; (I'ig. 35!)), the loops lying on both sides and crossing under, not above, th(> edges. Catgut or kangaroo teiidon should be used. The suture should i)e tightened after everv two or 650 DISEASES OF WOMEN. three stitches sufficiently to cause apposition of the lateral surfaces, but no constriction. Of late years I avoid includino; the muscle-fibers in the stitches. In themselves they are soft and friable, and do not give a strong cicatrice, and they prevent the sinewy tissues from growing together, which form the natural material where a per- manent resistance is Avanted. On the other hand, a muscle in its natural condition, not invaded by sutures, may be used as a pad out- side of the cicatrix, which it then serves to strengthen. Finally, the skin and subcutaneous adipose tissue are united by deep silk- worm gut and superficial silk sutures, or by a subcuticular, absorb- able running suture. This method, invented by Henry O. Marcy of Boston, consists in carrying the suture only through subcutaneous tissue and the edge of the skin without perforating the epidermis. An absorbable suture — catgut or kangaroo tendon — is introduced through the skin a quarter Fig. 356. ^-^ -Sii^^ Marcy's Subcuticular Suture. of an inch from the end of the incision, carried in the subcutaneous ti>sue close up to the skin, in a direction parallel to the edge of the wound for about half an inch, then brought out at the edge of the skin and in.serted in the other edge riglit opposite to the point of exit. Here it is carried subcutaneously in a similar way, crossing from side to side, at right angles, and finally brought out through the skin a quarter of an inch from the end of the wound (Fig. 356). By pulling on the two ends the edges of the wound are brought into contact. Next, the wound is dusted with iodoform, and covered with a layer of iodoform collodion, in whicii the ends of the suture are fastened. The collo- dion is strengthened by a few fibers of absorbent cotton, and the whole covered with a soft cotton pad.^ The same stitch may be used with a silkworm-gut suture, the ends of which are tied together over a ]>ad of iodoform gauze covering the wound, and which is removed wlien the wound is healed. Plalsted unites the edges with interrupted sutures of very fine silk. These sutures do not perforate the epidermis, and when tied they be- ' Henry O. Marcy of Boston, "The Surgical Treatment f)f Inguinal Hernia," Trans. N. Y. Stale Med. Association, vol. xi., 1894, reprint, p. 12; "The Animal Su- ture," Trans. Amer. Assoc, of Obstetricians and Gynecologists, 1889, reprint, p. 24. DISEASES OF THE OVARIES. 651 come buried. They are taken from the under side of the skin and made to include only the deeper layers, those which are not occupied by sebaceous follicles. The idea is to avoid the pyogenic organisms present on the surface of the skin and in the follicles.^ If the incision is long, two or three sutures should be used, meeting one another at their ends. Before closing the two upper rows of su- tures the wound should be irrigated with some antiseptic fluid (p. 217). If the patient is in a low condition, the operator should, however, abstain from all these niceties and close the abdomen in the speediest way, which is to insert silkworm-gut sutures through the whole ab- dominal wall, inclusive of the peritoneum, one for each inch. 4. Dressinc/. — When all the sutures have been tied and cut off, the abdomen is washed with a solution of corrosive sublimate, the wound dusted with iodoform, a compress of iodoform gauze laid over it, and a piece of gutta-pcrclia tissue, an inch wider than the com- press in all directions, placed outside of it. Next, the whole an- terior surface of the abdomen is covered with a thick layer of sterilized dry absorbent cotton ; this is held in place by six two-inch- wide straps of rubber adhesive plaster, six inches long and sewed to tapes, the first of which are fastened on the skin outside of tiie dressing and the latter tied over it ; and, finally, a fiannel binder or a many-tailed muslin bandage is put around the whole abdomen and pinned in front with safety-pins. 5. After-treatment. — After the operation the patient is placed in her bed, and surrounded by half a dozen bottles filled with hot water. I'i there is no shock, she is allowed to sleep till she awakes spontaneously. If slie vomits, the measures recommended on p. 242 are taken. The urine should be drawn with a catheter three or four times a day, if she is unable to pass it herself. Opiates sliould be avoided as much as possible on account of the danger of their para- lyzing the intestine. Pain may often be considerably relieved by ap|)lyiiig ail i('c-l)ag to the abdomen ; but gn^it pain is weakening, and calls, in my opinion, fi»r a hvpodermic injection of one-sixth to one quarter of a grain of morphine. If there is no s])ecial indication for doing it earlier, tlie bowels should l)e moved l)y a gentle aperient on the third day. I |)rcicr for this purj)ose a heaping teaspof»nfnl of sulj)liate of sodium or t.ii'- tratc of ])otassinm and sodium, to be repeated evcrv four hours if needed. T(» allow tlie bowels to i)e at rest too long is dangerous, because it mav give rise to occlusion of the intestine bv adhesions. Hefi/re the bowels ;ire moved much relief from flatulence is afl'onled by inti'oducing a soft-rubber rectal tube. If" salts are vomited, I substitute calomel (gr. j evcrv hour) ; and if that does not operate when ten doses are given, I give an ox-gall enema (j). 17H). ' Will. S. Halsttnl, .Johns Hopkins HoxinUd Bulletin, 1889, vol. i. p. 13. 652 DISEASES OF WOMEN. During the first day no food is given. Thirst is relieved by very small quantities of hot or ice-cold \vater or an enema of a pint of tepid water. The following day the patient may have tea, milk, thin oatmeal gruel, and beef-tea, in small, frequently repeated por- tions (not over two ounces at a time). After the first week she may have common food. If everything goes well, the dressing is not touched for a week. Then the sutures are removed as described on p. 236. The abdomen is washed with a solution of corrosive sublimate, the sutures are replaced by strips of rubl)er plaster, half an inch wide and cut out in the middle so as to leave free exit for any discharge from the edges of the wound. Then a similar dressing is applied as at the time of the operation. In this way the wound is dressed once a week, and the patient should stay in bed for three weeks. After removal of the plaster straps the abdomen is cleaned Avith chloroform, which dissolves rubber plaster, and after having been up a few days the ])atient may be dismissed. Slie should, however, wear an abdominal supporter (p. 199) for at least three months. Some gynecologists dispense with the bandage, just as some ob- stetricians have abandoned the binder after confinements. But there is no doubt that after the removal of a large tumor or the expulsion of the child an abdominal supporter helps to avoid that relaxation of the abdominal wall which is so unseendy, and may give rise to a numlxn' of more or less serious symptoms, such as loosening of the abdominal organs from their moorings, atony of the stomach, slug- gish blood circulation in the abdomen with consequent hyperemia, giving rise to metrorrhagia, menorrhagia, hematocele, hematoma, hemorrhoids, inflammation of the uterus and its appendages, stasis of the gall in the gall-bladder, constipation, and weakness of the heart.' Difficulties md vith during the Operation. — If an ovarian cyst does not contain much solid matter, has no adhesions, and lias a long and strong pedicle, ovariotomy is one of the easiest operations. But numer- ous and manifold are the difficulties which may arise, wliich often cannot be foreseen, and for which the operator must be pre])ared. Bladder in Front of Tumor. — Just as we have seen that the blad- der may be spread over the front of a uterine fibroid (p. 511), so this may be tlie case with an ovarian cyst. I-*ersistent Urachu.s. — See j). 522. Peritoneum taken for Ci/st-iraU. — In consequence of the irritation caused by the tumor the peritoneum is often much thickened, and, taking it for the adherent cyst-wall, the operator has sometimes peeled it off from the aI)dominal Avail. If this is only done over a small space, 'Compare the excellent paper by Dr. Illoway, Amer. Jour. Obst., Sept., 1898, vol. xxxviii. p. 331. DISEASES OF THE OVARIES. 653 it is immaterial ; but if a large surface has been denuded, the peri- toneum, in order not to lack nourishment, and to prevent suppura- tion, must be stitched to the abdominal wall either by a continuous catgut suture or by the so-called mattress-suture-:— i. e. interrupted sutures going through the whole thickness of the abdominal wall — and tied over a quill or a small roll of adhesive plaster. If the operator is in doubt whether he has to do with the perito- neum or the adherent cyst-wall, it is better to continue cutting cau- tiously, even at the risk of extending the incision into the cyst. Adhesions may cause great trouble or even render the extirpation impossible. Adhesions to the abdominal loall may often be easily severed by pushing a male urethral steel sound between the abdominal wall and the cyst before tapping. If tliere is much resistance, the flat hand is introduced, and the ulnar edge of it used in the way a paper-cutter separates the leaves of a book. On account of bleeding it is, how- ever, not safe to go too far out, and more resistant adhesions should be left till the cyst has been emptied. If the adhesion is found in the line of incision, this should be extended upward above the adhesion, until a point is reached where the abdominal cavity is opened, and then the adhesions should be attacked from this point. If this cannot be done, the operator should cut into the sac and invert it. I-iong and resistant adhesions are cut between two ligatures. If they are too short for that, they should simply be cut and the bleed- ing points caught with pressure-forceps. Adhesions to the intestine are very serious. If an adhesion is string- shaped, it may bo torn or tied between two ligatures. If it is broad, it may be severed by pulling on the sac or pushing this away from the intestine by means of a sponge on sponge-holder. If it does not yield readily, a piece of the outer layer of the sac is cut out, and left on the intestine (p. 513). If the adhesion is very extensive, it is bet- ter not to try to separate it at all, but either to desist altogether from tlie operation or be satisfied with an incomplete operation by marsu- pialization, as will presently be described. If the intestine has been injured, it nnist i)e attended to, as even the smallest puncture may allow the contents to enter the ])eritoneal cavity, and as any place deprived of its peritoneal coat is apt to rupture. A mere puncture may be seized with foreej)s and surrounded by a ligature. TIh' edges of a longer tear must be brought together : if it is onlv peritoneal, they may be united with a continuous suture; but if th(! whoh; wail is torn through, the edges should be united by a rV.ernv-Lembert suture ; that is, a donbh' row, comprising the iniiscular layer and the peritoneum, l)Ut not the nineous membrane. 654 DISEASES OF WOMEN. the outer a quarter of an incli outside of the first. A fine cambric needle, threaded witli the finest iron-dyed black silk, is used for this delicate "svork. The inner suture may be interrupted or con- tinuous ; the outer is always continuous. If a rectangular suture is used, one row suffices. If the intestine has suffered much, it may become necessary to excise a portion of it. Small bleeding surfaces on the intestine may be seared by holding a Paquelin cautery a short distance from them, or they may be touched with Monsel's solution. The injured part should be kept near the incision, so as to favor the formation of a fecal fistula in case healing fails to take place. Serious injury to the intestine is commonly fatal. Special attention should be paid to the appendix vermiformis. If it is adherent to the cyst, and not easily detached, it should be cut off between two ligatures, the stump inverted, pushed into the caecum, and the peritoneum united with a running suture. (See Appendix.) Adhemons to the mesentery are vascular. If possible, they should, therefore, be tied before cutting. If that is not feasible, they must be cut, and a suture passed under the bleeding part. As much as possible, blunt instruments, such as a pair of closed blunt scissors or the finger-nails, should be used. If a large surface has been denuded, the edges should be united with a running suture. Adhesions to the omentum are common and bleed easily. They are best separated with a sponge squeezed dry. If they are exten- sive, a part of the omentum must be cut off, for which purpose it must be ligated in sections. Large veins may extend all alone without being accompanied by other tissue from the omentum to the abdominal wall or down into the pelvis. They are easily torn, and must l)e severed between two ligatures. No rent should be left in the omentum, as the intestine may be caught in it and become strangulated. Its edges should be united with continuous catgut sutures or the whole cut off. Adliesions to the liver and the spleen may cause severe hemorrhage. If they are not easily separated, it is better to leave part of the cyst- wall on the viscus. Bleeding from these organs may sometimes be stopped with Paquelin's cautery or Monsel's solution, and, best of all, with a current of steam directed for half a minute against the bleeding surface.' The operator should be careful not to tear the gaJl-t)lnddei\ If the accident happens, the tear must be comprised in the sutures closing the abdominal incision, temporarily establishing a biliary fistula which closes spontaneously. If this organ is badly torn, it is necessary to remove it entirely. 'Snegireff, Berliner Klinik, April, 1895. DISEASES OF THE OVARIES. . 655 Adhesions to the pelvis are the worst of all, as they are broad, deep-seated, and may implicate the ureter or large vessels. If the tumor is small, it is best to sever them before emptying it. It may be necessary to do so guided by the touch alone, although a great lielp has been secured in the management of such cases by the in- vention of the elevated-pelvis position (p. 141). It may be better to leave the outer layer of the cyst where it is adherent or to cut off the free part of the cyst and stitch the remainder to the abdom- inal wound. The ureter may have to be dissected out in order to free it from adhesions. If the ureter is injured during a laparotomy, the injury is to be remedied in one of the following ways. If the wound is lateral, the edges should be united by suture without penetrating the mucous membrane. If the ureter is torn transversely, but the ends remain in contact with each other, the same course should be pursued or tlie ends should be cut in a slanting direction before uniting them end to end (Bov6e).' Sometimes it is possible to introduce the upper end into the blad- der and stitch it there by intra-peritoneal cystostomy (p. 395). A sim])ler method and one which has given excellent results is that of Van Hook. The end of the lower portion of the ureter is closed with suture ; a longitudinal incision a quarter of an inch long is made into its wall below the closed end. A slit is also made in the end of the upper portion, in order to make the opening larger; a catgut thread, with a needle at each end, is carried through tlie wall from within outward, opposite the slit. Next the needles are inserted through the opening in the lower portion and ]>ushed tlirougli the wall, half an inch below the slit. ]iy gentle manij)ulation the upper extremity is dniwn into the lower tube, and the suture being tightened and tied the slit is entirely occluded.^ If no conservative method is available, nephrectomy should be ])er- formed at once, provided tlu; patient ap])ears able to stand the sliock. If she is too weak, a provisional urinary fistula should be established by making an incision in the lumbar region, suturing the up})er end of the ureter to it, and leaving a catheter in it. Tlie other end is lilJated and sutured to the lower end of tiie abdominal wound. If a '.T. Wesley Bovtje of Washinjifton, D. C, " TTrotero-iireteral Aiiastotnosis," Annals of Saiy/r.ri/, .Jan., 1S97. He re<-()iiiinonds silk in preference to catfiut, t)eratise it knots more firmly, siu-h long ends neetl not he left, and it occnpies less space in the ureteral wall. He re(;ommends also to use rectany;nlar sutures aitcrnaliiifj with ihe sin^^le interrui)ted. He thinks drainage should he used only in cases in wliich there is pus. ' Weller Van Hook of Chicago, "The Surgerv of the ^reter.^'' Jour. Aincr. Med. Assoc, 1893, vol. xxi. pp. !»1], Wo. 656 , DISEASES OF WOMEN. fistula forms here, another catheter is introduced and left in it. A tiiird is introduced throuoh the urethra into the bladder. From all three catheters rubber tubes go into vessels containing a solution of boric acid. When the patient has recovered, the kidney is extirpated.* If the litems has been Avounded, the bleeding may usually be stopped by passing a ligature under the bleeding point, by stitching some loose tag of peritoneum to it, or by searing it with the thermo- cautery. If, hoAvever, the hemorrhage cannot be checked in any other way, the uterus must be removed. The cyst may be so adhevcyd everywhere that it cannot be extirpated. In making the first incision the operator enters it, and the sac cannot be inverted. Then there is nothing to be done except to empty it, stitch it to the abdominal incision, wash it out, and pack it with iodoform gauze, which is changed every four or five days {mar- supiaUzaiion). Under this treatment the sac shrinks and fills with granulations. If an irremovable cyst has colloid contents contained in numerous small compartments, the upper and lower ends of the incision should be seized with volsellse and held up against the abdominal wall. The compartments should be broken up with one or more fingers or the whole hand. Sometimes adhesions in the upper part may be overcome by seizing the lowest part from within and inverting it. In other cases it suffices to let an assistant introduce his hand into the sac and put it on the stretch, while the operator severs it from its surroundings. If the cyst contains much solid matter, it is best to tie the pedicle and extract the lower end first. If the solid matter is found below, while the upper part forms a large cyst, the trocar should be pushed through the lower solid part into the upper cystic part, thus giving an outlet to the fluid, and then the upper ])art should be pulled out first. If it becomes necessary to pull the intestine out of the abdom- inal cavitv in order to sever adhesions or stanch bleeding, it should be laid on the upper part of the abdomen, and covered with cloths wrung out of warm salt water (p. 531). The elevated-pelvis posi- tion has, however, rendered this evisceration superfluous in most cases. Intrnlif/amentous Development. — Ovarian tumors that develop in the broad ligament are usually papillary (p. 614). They are smaller, grow more slowly, and have "fewer daughter-cysts. Their papillomas may rupture the cyst- wall and lie free in tli^ peritoneal cavity or grow into neighboring organs. They are more malignant, and are very apt to cause metastatic infection of the peritoneum. They are diffi(.'ult to remove, and special care must be taken to avoid infec- tion. The uterus is at first pushed over to the other side by the tumor, ' Puzzi, Centralbl f. Gynulc, Feb. 4, 1893, vol. xvii. p. 98. DISEASES OF THE OVARIES. 657 later elevated and immovable. When the lower limit of the broad liga- ment is reache<l, the tumor may develop forward or backward. If it goes forward, it strips off the peritoneum from the abdominal wall, and thus it is reached in making the abdominal incision before the peritoneal cavity is opened. Such tumoi^s may occasionally be removed without entering that cavity at all, but, as a rule, it becomes necessary to do so at a later stage of the operation. If the development takes place backward, the tumor separates the layers of the mesentery and comes to lie behind the large and small intestine. The inti'aligamentous tumor may also burst through its peritoneal covering, so as to present an upper intraperitoneal and a lower extra- peritoneal part. That portion which is free from the peritoneum has the usual pearl-gray color of ovarian cysts, while that which is cov- ered with peritoneum is pink. In exceptional ca^^es the tumor is even covered with a thick layer of unstriped muscle-fibers, which gives it the appearance of a uterine tumor. The ovarian vessels enter the tumor at itfi outer border ; the uterine follow the Fallopian tube and enter on the middle of the surface. The intervening part of the broad ligament may give way, so that the tumor has a double pedicle. Smaller cysts with thin walls are often present, and the uterus usu- ally lies in the angle between the chief cyst and the smaller ones. Rarely the whole encapsulated cyst can be drawn out and re- moved entire by forming a pedicle of tiie broad ligament. If the outer and lower parts of the ligament are free, the surgeon may put in a double row of sutures, beginning at the infundibulopelvic liga- ment, and cut tlie tissue that lies between each two sutures, whereby the deeper parts become more accessible. The following suture must always eml>race part of the mass comj)rised in the preceding one, in order to avoid hemorrhage. (Comj)are Vaginal Hysterectomy, p. 510). Proceeding in this manner we get under the cyst and diminish its attachment, until finally tiie tube and the rest of the broad liga- nient can be enclosed in one ligature. If the cyst extends down to the lower edge of the broad ligament, it can only i)e removed by enucleation (Miner's method),' which consists in stri|)ping the cyst of its j)erit()neal covering, and leaving this or part of" it as an empty sac. If the tumor does not rise much above the superioi- strait of the pelvis, tiiis is done by making an incision through the peritoneiun at the upper end of llu; tuni<»r and pushing it down with fingers and blunt instruments. If, <tn the other hand, the cyst is large, it should be emptied and pulled out to the level of ' JtiliiiK Francis Miner of I'liflhio, N. Y., jierforincd tlic (irst operation of this kind in 1H(;9, and in tlic follow inj: year piihlislicd tlic inctliod (Atixinson Iii<>(ii(i])hi- <(d hirtiinuiri/ of (oiilimixirary Amrrlrun I'hyxiridns (tnd Siirijfnns, I'liiladclpliia, ISSO, p. ir,,. 42 658 DISEASES OF WOMEN. the abdominal wall. On account of the dangerous character of the fluid and the inner wall, the opening in the cyst should not be en- larged with the knife nor })a|)illomata broken oft', but the hole left by the trocar should be closed with forceps. Next, a small incision is made on the anterior surface in a transverse direction. The peeling is begun here, and it is gradually extended all around the circum- ference. Before doing so the ovarian vessels should, however, be tied be- tween two ligatures and cut ; and if large veins are found in the invo- lucrum, they must be disposed of in the same way. Branches of the uterine artery which are severed in cutting the peritoneum are also tied. When the ovarian ligament and the Fallopian tube and the anastomosis between the uterine and the ovarian, that lies just under the inner end of the tube come within reach, they should be tied and cut ; and, finally, the uterine attachment is tied with one or more mass-ligatures. They include sometimes a part of the uterus itself, and it may even become necessary to perform supravaginal hysterectomy (p. 517). Often a large part of the uterus is left without peritoneal covering, and may bleed ; which hemorrhage may be checked by passing a con- tinuous catgut suture under the bleeding surface or inserting inter- rupted sutures under it or touching it with the thermocautery. It often happens in operations involving the broad ligament, the cornu, or the lateral edge of the womb that the tissues are extensively torn or so decomposed as to break down under the fingers, forceps, or ligatures. In such cases hemorrhage may be controlled by tying one or both uterine arteries and one or both ovarian arteries. For the purpose of tying the uterine artery the uterus should be drawn toward the opposite side. A stout curved needle armed ^vith strong silk or catgut, a foot long, is carried a quarter to half an inch below the lower limit of the tear, just entering the substance of the uterus. It is car- ried back throup-h the broad lirament about half an inch outside of the uterus and tied. The ovarian artery is easily secured in the in- fundibulo-pelvic ligament. When a large piece of the broad liga- ment has been removed, the raw surface may be disposed of by uniting the inner edge near the uterus with the outer near the pelvic wall by a few sutures, thus producing an artificial latero-version.^ The development into the mesentery gives rise to considerable hem- orrhage, Avhich must be overcome by mass-ligatures. Pieces three or four inches wide may be ligated without causing gangrene of the intestine. If part of the cyst is imbedded in the pedicle, its inner layer should be scraped out with a sharp curette or seared with Paquelin's cautery. * H. A. Kellv, Johns Ilopkms' Hospital Reports, Gynecology 1, Baltimore, Md., Sept., 1890, pp. 220-223. DISEASES OF THE OVARIES. 659 Sometimes, as a result of inflammatory processes, the peritoneum is so adherent to the intraligamentous ovarian cyst that in places it cannot be stripped oif, but has to be dissected off from the tumor with a knife, or the separation made within the limits of the tumor itself. In these difficult cases the peritoneal covering is often torn, and severe hemorrhage may take place. If papillomas have grown from the ovarian cyst into other organs, these parts are temporarily left, and after removal of the tumor they are, as far as possible, scraped out with nail or curette or cut out with the knife, to which treatment the uterus lends itself more readily than other organs. At the base of the tumor a sharp lookout should be kept for the ureter, which runs in a nearly antero-posterior direction, and is rec- ognizable by its hardness. Great care must be taken not to tear it, cut it, or comprise it in a ligature. After the enucleation, a large raw surface is left, which may be treated in different ways, as describetl in speaking of Fibroids (p. 526). Pseudo-intraligamentous Ovarian Tuviors.^ — There is a kind of ovarian tumor which simulates intraligamentous tumors, but in reality is adherent to the posterior surface of the broad ligament, which it draws up in front, sometimes high up in the abdominal cavity. The upper end and the posterior surface of the tumor may be free or covered with a pseudo-membrane of peritonitic origin, which is entirely like the peritoneum. The bottom adheres to Douglas's pouch. These pseudo-intraligamentous tumors can hardly be diag- nosticated clinically from the intraligamentous, except when the latter adhere with a broad surface to the vagina proper, situated laterally to and behind the uterus. The vagina is then immovably fastened to the lower pole of the tumor. A history of gonorrheal or puerperal peritonitis makes it likely that the tumor is pseudo-intraligamentous. Even when the abdomen is opened, it may be quite difficult to recognize the tru(! condition, and still it is of great imj)ortance, since it complicates the operation very much, if the operator enters the space between the layers of the broad ligament. Sometimes the tube may be separated from the tumor, and the separation continued along the posterior surface of the broad ligament, or one succeeds in getting behind and under the tumor and loosen- ing it from the ])eritoneum in Douglas's pouch. Th(^ best way of removing the lower end of the tumor is to j)ull on the sac after free- ing it from adhesions above, and tying the tube with a double ligutui'e near the uterus, and severing it with the thermocantery. Incomplete Operations. — SoiTK.'times it is impossible to remove the tumor, even by enucleation. Then three methods are at our com- mand — viz.: 1, marsupialization; 2, to leave the remainder and ' K. Pawlik, Ueber I'seudo-i»Jeiii;/<imriitiJxi' Eirrslock-KffeschwiilMe, Wieii, 181)1. 660 DISEASES OF WOMEN. close tlie abdomen ; 3, (lrainap:e through the vagina. But if it is evident that the operation cannot be finished, it is better not to operate at all. The conditions which make it impossible to per- form a complete extirpation are general adhesions, subserous devel- opment in its worst forms, and cancer which has spread to the surroundings. Jlarsupialization consists in stitching the edges of the tumor to those of the abdominal wall, so as to leave a pouch which has been likened to that in which marsupialian animals carry their young. This method is particularly indicated in monocystic tumors. If it is a papillomatous cyst, all vegetation and, so far as possible, the whole mucous layer on the inside of the cyst, should be scraped oif. Some- times the whole tumor is left in the abdominal cavity ; in other cases as much as possible is removed, and the rest stitched to the abdomen. If the opening in the cyst is larger than that of the abdomen, the cyst- wall must be folded so as to adapt itself to the abdominal incision. The interior of the cyst is packed with iodoform gauze, which is changed every few days. After a week when adhesion has taken place, the cyst may be injected with antiseptic solutions. The sac almost invariably suppurates, healing may take many months or even a year, the patient's strength may give out, a fistula may remain, or a relapse may occur. If the tumor is papillomatous, proliferation usually continues and puts an end to the patient's life in a few months. If, on the other hand, everything goes favorably, the sac fills gradually with granula- tions, and shrinks until the wound closes. If the tumor is polycystic, it is better to leav^e what cannot be re- moved and close the abdomen.^ If the tumor has an involucrura so full of large blood-vessels that the operator deems it impossible to remove the cyst, he may puncture Fig. 357. Boldt's Blunt Expanding Pelvic Dilator. it from the vagina with lioldt's blunt expanding dilator (Fig. o-")?), empty the cyst, and leave a drainage-tube in it. But this vaginal treatment, like the alxlominal, may give rise to an interminable secretion. ' Olshaiisen in Billrotli and Liicke's Frauenkrankheilen, vol. ii. p. 591. DISEASES OF THE OVARIES. 661 It has been sugji^ested ^ to cut off the blood-supjily of irremovable tumors by tying the ovarian artery in the infundibidopelvie liga- ment, and the uterine by passing a ligature round it with a curved needle from the vagina (p. 188) and again at the corner of the uterus. If possible, tlie cyst should then be stitched to the wall, opened, and drained. If the cyst is papillomatous or suppurating, it is, however, not desirable to proceed in this manner, on account of the danger of infection in passing the sutures. In such cases, and in others in which it is not possible to stitch the cyst to the wall, the abdomen is closed, the dressing applied, the patient's feet are lifted up, and the tumor opened from the vagina in the way just de- scribed. This is done bv thrustino; a stroup; blunt dilator into the opening made with the first, and expanding it. This will give a free opening, by which we can both emj^ty the sac and ensure free washing and drainage. A rubber tube with wings should be inserted into the cyst, or, better, the sac packed with iodoform gauze. Later on, from day to day, the mass may be broken down with a dull curette and the sac injected with diluted tincture of iodine of increas- ing strength, or peroxide of hydrogen. The Pedicle. — If the ])edicle is thick and short, there is danger of the outer part of the ligature slipping. This may be obviated by repassing it near the edge before t\ing it, or by first making a notch by passing a finer silk ligature around the pedicle one-third of an inch from the edge, and tying it before tying the thick pedicle-ligature. If the pedicle is so short that the ligature encroaches on the uterus, it is a protection against hemorrhage to unite the edges of the peritoneal covering of the stump with sutures. If it is very thick, it is necessary to tie it in more than two parts by means of a duiin- ligature. A long thread is carried with a handled needle through part of it, and seized witii a pressure-forcejvs. Next, the long end ot the same thread is carried through in one or more other places, and the loops secured in the same way. When all are in place, the loops are cut, one after the other, near the forceps, and the halves crossed and tied, so that finally the whole mass to be ligated is enclosed in threads, forming together a chain (Fig. ^58). The })edi('le mav be cut gradually, leaving at least half an inch of tissue above the liga- ture, and for greater safety it is advisable U) tie arteries visible on the cut surface with silk or catgut. }f(frcjfs Mcfliod' (Fig. ^359). — A handled needle, carrying a long tendon or catgut thread, is inserted through the j)art of the judicle ' \i. McK. p:nin)ctt, Aiwr. Jour. Ob.<t., .Inly, 1^90, vol. xxiii. j). TOO. ' Henry (). Marcy roixirtcil tliis nu'tliixl :it tlio Ititeriiational ('(iiiL'ress in l^niuloii, 1881, aixl rlaiins to lie tlic inventor of ilic slioeinakiT's stitcli : " Tlio Surpical Ad- vantages ot" the Buried Animal Suture," Jour. Aincr. Med. .twir., .Inly '2\, 1888, reprint, p. <>. 662 DISEASES OF WOMEN. farthest away from the operator (1). One end, A, is held by the assist- ant ; the other end, B, is pulled out from the stitch-canal and the eye of tlie needle (2), the needle threaded with A (3), pulled back (4), and then pushed with A through another part of the pedicle. Now A is Fig. 358. Wallich's Chain-ligature :— 1. P, pedicle : ppp, pressure-forceps ; aa, loops ;— 2, ligatures cut, crossed, and tied loosely. pulled out from the eye, B inserted (5), and the needle pulled back with B. Finally, the two ends are tied with a surgical knot over the la.st part of the pedicle (6). This does not tear the tissue, and com- pre.s.ses the whole pedicle tightly. It is only another way of making a cobbler's stitch. DISEASES OF THE OVARIES. 663 In dealing with thick pedicles it is also useful to compress them with Spencer Wells's forceps, so as to form a notcli before tying. If a hematoma forms under the ligature of the pedicle, another ligature should be placed nearer the uterus. The blood between the two ligatures is left to be absorbed. If the tube appeal's inflametl or if the stump contains parts of the cyst, the cut surface should be cauterized. If in combination with a \^ Cobbler's Stitch for I.igntioii of Pedicle. pcdiinctihited tumor we find metastatic masses behind the ])critoneuni, tlie hitter must be left alone. H the pedicle is so frial)le that the ligature cuts through, the single vessels must be se<'ure<l with forceps left in the wound. After the removal of a large tum(»r which has caused great dis- tention of the abdomiii.d wall, part of the skin and peritoneum insid(! of the recti muscles should be trinnned off before closing the wound. 664 DISEASES OF WOMEN. Toilet of the Peritoneum. — If adhesions have been torn, and blood or other fluids, such as pus, oyst-conteuts, etc., have found their way into the peritoneal cavity, it must be cleaned, the technical term for which procedure is the toUet of the peritoneum. Sometimes it is enough to introduce a few sponges or pads on sponge-holders into Douglas's pouch. If the bleeding is more profuse or more objectionable fluids have found their way into the abdominal cavity, it should be flusiied M'ith hot water to which table-salt has been added in the proportion of 6 : 1000. This is poured into it from a pitcher or through a thick glass tube. This saline solution comes very near the composi- tion of serum, and attacks the epithelium less than jilain water or an- tiseptic fluids. If there is still some oozing, the abdominal packing with iodoform gauze (p. 186) may be used. Only if there seems to be a decided hemorrhage, it is necessary to hunt for its source and tie the bleeding vessel. Experience alone can guide the operator in this respect. Hemostasis. — For arresting hemorrhage four methods are avail- able — pressure, ligature, cauterization, and styptics. A small hemorrhage may be arrested by simple pressure with a finger or sponge. A liberal use of pressure-forceps saves much time by avoiding many ligatures. Bleeding from larger surfaces in the pelvis may be arrested by packing it with sponges, pads, or cloths, which should be left in sometimes as much as fifteen minutes, while counter-pressure is being made from the vagina, and removed very cautiously, so as not to tear off newly formed coagula. Sometimes long forceps have to be left in the wound till the next day, but this should be avoided as much as possible. It is better to pack the peritoneal cavity with iodoform gauze (p. 186). After the abdomen has been closed, pressure may yet be used to arrest oozing by means of a tightly fitting bandage or two bricks placed outside the dressing, combined with packing of the vagina and a bag filled with ice-water in the rectum (p. 484). Bleeding from a large surface on the anterior abdominal wall may be checked by folding that part of the wall and excluding it from the abdominal cavity by passing some -quilled sutures at the base of the fold, which are left in place fi)r two days (Kimball's^ method). When blood may be expected to flow from both ends of a divided vessel, it is, if possible, cut between two ligatures. If this is not possible, it is cut, and both ends are seized and tied or com])reased with artery-forceps. It is safest to tie the isolated vessel that bleeds, but often this cannot be done, and we must be satisfied with a mass- ligature embracing the surrounding tissue. Bleeding from a sur- face may be arrested by passing a continuous suture under it and drawing it together. Sometimes loose tags of peritoneum are used as ' Oilman Kimball of Lowell, Mass. DISEASES OF THE OVARTES. 665 a patch. Bleeding from the anterior abdominal wall may sometimes be arrested by tying the corresponding epigastric artery. Cauterization has become quite convenient since Paquelin invented his thermocautery. It can be applied to bulky organs, such as the ab- dominal wall, the uterus, the spleen, and the liver; it can be used for cutting; and, iield at a distance, it has even proved successful in deal- ing with hemorrhage from the intestine. Tincture of iodine or Monsel's solution may be used as a styptic to smear on small surfaces of delicate organs, such as the intestine or bladder, but their use ought to be avoided whenever possible, as they form coagula which may become a source of inflammation or sepsis. Hot water is an excellent hemostatic, which operates by causing con- traction of the capillaries. A current of overheated steam led through a tube ending in a perforated nozzle like the rose of a watering-pot is said to be effectual in arresting hemorrhage even from large arteries (p. 054). In order to find the bleeding spot, it is sometimes necessary to enlarge the incision and even to draw out the intestine (p. 565). The search may be facilitated by throwing light into the abdominal cavity with a concave mirror, a large })lane mirror, or, still better, with a portable electric lamp. Much hemorrhage may be avoided by tying the pedicle as soon as possible, before beginning to separate adhesions. CompUcatioHK. — If a small myoma is seen in the uterus, it should be let alone, but its presence may be an inducement to remove the second ovary (p. 503). A large myoma may be in the way, and have to be removed according to circumstances (p. 503, d seq.). If the ovarian cyst is accompanied by at^cites, nothing should be done to remove the latter before the cyst is taken away, for the fluid serves as a diluent for any cyst-fluid that may enter the })eritoneal cavity. If the jKitient is afl'ected with an iiinhUh-dl or irnfntJ hernia, its sac shotdd b(! dissected out, and the thinned and superfluous tissues cov- ering it be cut away. Complication with jji-ef/nancj/ has i)een considered above (p. 637). If the j)atient is not seen l)efore /abor has set in, and an ovai'ian tumor obstructs the ])arturient canal, the oj)erator should try to ])usii it u)) into the abdominal cavity in tiie genupectoral position — a treatment which is, however, only applieal)le to small tumors. A large tumor should be ta|)pe<l from {\iv vagina (j). 640). li it does not collapse sutlieientlv, an incision may l>e made in the vagina, and the tumor removed or diminishr'd in this way. If it contains nuicli solid matter, craniotomy or Cesarean section may be ])referal)le. In the latter case ovariotomy should l)e added. J)r(iiii(i</c. — We have seen in the general i)art of this work (]). li>5) 666 DISEASES OF WOMEN. that the most experienced laparotomists entertain very divergent views as to the use of drainage. While some look upon it as a fifth emunctorv, of which thoy are very willing to avail themselves, others are loth to have recoui-se to it. In a general way it may be stated that it is indicated when pus or other irritant fluid has entered the peritoneal cavity during the operation ; when sepsis or peritonitis is present; when there is nmch ascites, especially in connection with papillomata; when there are many or large raw surfaces left; when the bladder or intestine has been wounded during the operation or is found in a sloughy condition ; and when the operator is in doubt about the efficacy of his hemostasis. Drainage-tubes have to a great extent been replaced by iodoform gauze, which has the advantage of being soft and of helping to check hemorrhage. It may be left in place from three days to a week. The objections to the use of drainage in the peritoneal cavity are that it irritates the peritoneum, may cause uncontrollable vomiting, interferes with free movements of the intestine, predisposes to intes- tinal obstruction, the formation of fecal fistula and ventral hernia, and maintains a danger of infection.^ Some prefer drainage through the vagina, a method which has already been referred to in speaking of enucleation of fibroids from the broad ligaments (p. 526), which is particularly indicated in cases in which the tumor extends far down into Douglas's pouch, and by which ventral hernia is avoided. It is established by means of iodo- form gauze or a soft-rubber drainage-tube. Two fingers are passed up through the disinfected vagina to the posterior vault. An opening is made from above through the bottom of Douglas's pouch with scissors or trocar, and dilated Avith forceps or an expanding dilator, until a finger can easilv be passed through it. A strip of iodoform gauze, four inches wide, is passed through from above into the vagina, and packed in or around the part from which one wishes to drain. After closure of the abdominal cavity the vagina is j)acked Avith iodo- form gauze. If there is a rise in temperature, the vaginal packing should be removed, and the abdominal gauze pulled out a few inches, which produces free drainage. At the expiration of from eight to tAvelve days the last of the abdominal gauze should be withdrawn. If there yet is a purulent discharge, a soft-rubber drainage-tube with crossbar should be introduced instead.^ Such tubes cause, however, a good deal of irritation, make the vagina very tender, and may pro- duce ulcers, a C(jndition which is successfully combated by injecting stearate of zinc with a powder-blower into the vagina, after having ' A strong plea in its favor is made by E. W. Cnsliing of Boston, Mass., supported by Lawson Tait and Bantock, in Annah of Gynecolorfy, Nov., 1890, vol. iv. p. G9. ' H. T. Hanks, "Counter-drainage after Cceliotomv," The PoM- Graduate, No. 4, 1893. DISEASES OF THE OVARIES. 667 injected a saturated solution of boric acid through the tubes and into the vagina. It ought to be distinctly understood that the more perfect asepsis is, the less drainage is needed ; and except in the conditions enu- merated it is nuicli better to do without it. Shock. — The sudden giving out of vitality called shock is very dangerous, and calls for immediate attention (see p. 224). Complications during After-treatment. Shock. — If shock is present after the patient has been brought to bed, she should be roused (p. 239) and stimulated as just described. Vomiting. — If the patient vomits, the medicine with hydrocyanic acid mentioned on p. 224 should be administered. Deep inspirations may be tried, by which air containing remnants of the anesthetic is expelled from the deeper part of the lungs. If vomiting continues at a time when the patient should take food, the diiferent modifica- tions of milk — peptonized milk, kumiss, or matzoon — can often be retained when everything else is ejected. If the patient vomits everything ingested, she must be fed by rectal alimentation, for which milk, eggs, and beef extracts are particularly useful (p. 241). As a rule, an ounce of brandy shoidd be added. The whole enema, in order to be retained, should not be more than six ounces. If vomiting accompanies intestinal obstruction, calomel is the best remedy. Internal Hemorrhage. — After bloody ojicratlons the patient may be very weak and n-stlcss, with a weak, rapid, and irregular pulse ; but if tlicrc is no bleeding, this condition will yield to the free use of stimulants, or injection of hot water into a vein or the rectum or under the skin (p. 224). IlemorrliMgc conies nearly always from the pedicle, rarely from large raw surl'aces. If a (lrainage-tub<> has been left in the abdo- men, the continuous appearance of pure blood after the tube has been emptied furnishes the diagnosis. Otherwise it must be made by the general condition of the patient — weakness; restlessness; weak, raj)id pulse ; cold, clammy skin ; and swelling of the abdomen. Then only two sutures should be removed, which will sutHce to as- certain the |)resence of blood in the abdominal cavity. If it is found, the whole wound must be reopened, and th(> source of the hemori"h;i^'e — first of all, the pedicle — looked for. When found, th(> l)lee(ling is arrested by means of ligatures, and the cavity cleaned and closed again. If the |)atieMt has lost nnich blood, injection of saline solution may prove of great value. TiiiiijX'nitrs with(»iit inflammation is nnich relieved bv the intro- duction of a soft-rubber rectal tube ; by enemas with turi)entine (,sss 668 DISEASES OF WOMEN. to Oj), with sulpliate of quinine (gr. v every four hours), or with infusion of nientha viridis (sij to aquoe Oj) ; by the administration of tinct. nucis vomicfe or tinct. capsici (V(lv every hour), or large doses of sul)nitrate of bismuth (gr. xxx-xl) ; by standing the patient on her head ; by loosening the t<apes crossing the abdomen, draw- ing up her knees, using faradization, or puncturing the transverse colon. Ekvaiion of Temperaixre. — The temperature should not rise above 100° Fahr. As soon as it does, the cause should be looked for, which may be constipation, emotions, suppuration of a stitch-canal, a mural abscess, peritonitis, or sepsis. An ice-bag or rubber coil with running ice-water should be applied outside of the dressing. Anti- pyretic drugs should be administered. One or more sutures may be removed to give exit to pus. If the temperature rises more than two degrees above the normal average, and swelling of the abdomen announces aj)proaching peri- tonitis, the bowels should be moved at once, which may be done with sulphate of sodium, a teaspoonful every hour, and an enema with ox-gall (p. 178) given in the mean time. Suppression of Urine. — If the secretion of urine stops, it should be promoted by giving digitalis and acetate of potassium. If a ureter has been tied or injured, a urinary fistula may form in the vagina, M'hicli sh.ould not be interfered with until the pa- tient has recovered. Hydronephrosis has developed, and been cured by extirpation of the corresponding kidney. In another case a cui'e was effected by pushing a trocar through the urethra and bladder into the abnormal reservoir, and leaving the canula till heal- ing had taken place. Perhaps it might suffice to remove the ligature from the uterine artery (p. 530). If not, the ureter may be cut above the ligature and implanted into the bladder by intra-peritoueal uretero-cystostomy (p. 395). Intestinal obstruction is marked by constipation, vomiting, and tym- panites. It is often due to adhesions between the stump of the pedicle and the intestine, and is now-a-days, as a rule, avoided by moving the bowels early. If this grave complication occurs, large ox-gall enemas (p. 178) should be given. By using a fountain syringe and low press- ure (p. 179) several quarts may be injected. Calomel is the best ape- rient, because it is least likely to be vomited. Tinct. belladonnse or atropine may help to relax the bowel. A very efficacious remedy is to wash out the stomach with five or six quarts of lukewarm solution of table-salt, which produces strong peristaltic movements of the intestine. If this does not give relief, a second lavage is made, followed by the introduction of nearly two ounces of castor oil through the stomach-tube.^ ^ Klotz, Centralblatt f. Gyndk., 1892, vol. xvi., ^'o. 50, p. 977. DISEASES OF THE OVARIES. 6Q9 If these milder means fail, the abdomen must be reopened and the obstruction removed manually. Septic Peritonitis. — In spite of all antiseptic precautions, some pa- tients develop peritonits, which is probably always of septic origin, and may lead to general septicemia and death. The infection cannot always be blamed on the operator, as it would seem that pathogenic microbes can find their way through the wall of the intestine to the peritoneal cavity (p. 529), where they find an excellent soil in blood and serum. Often the drainay-e-tube has been the door through which infection has entered. Peritonitis develops, as a rule, within four days. It is character- ized by green vomit, tympanites, tenderness of the abdomen, and a frequent pulse. Often there is no rise in the temperature, which, on the contrary, may be subnormal. The bowels should be moved at once, five grains of quinine or salophen given every four hours, brandy administered freely, and an ice-bag or ice-water coil applied to the abdomen. Finally, the wound may be reopened and the peritoneal cavity washed out with peroxide of hydrogen, but the ciiance of recovery is then slim indeed. I have seen a patient who evidently was dying of septicemia saved by merely taking out a couple of sutures from the abdominal incision, which gjive exit to a great amount of gas. Nothing was injected, and the abdomen was closed again. If peritonitis supervenes as late as ten to fifteen days after the operation, it is probably due to mortification of the pedicle or other large masses that have been ligated, and treatment is then nearly powerless. A jimral abscess is recognized by hardness and tenderness of the affected part. A small opening should be made, a drainage-tube in- serted, and the abscess-cavity washed out daily with peroxide of hy- drogen. If the ai)scess has formed around a suture, this should be removed, the pus pressed out, and the dressing changed daily. A deep (thscess may 1)C made out by bimamial examination. If it lies close up to the vatniia, it should be oj)cned and drained from that point. If not, the abdomen must be reopened, cleaned, and drained either tiirongh the skin or through the vagina. J'Jrtijjln/-'^eiii(i of the alxlominal wall is rare, i)ut is of importance, in so far as it j)redisposes to the formation of an abseess. Sijoiifaiuoiis reopciiiiir/ of the wound is an unfortunate occurrence that mav to a great extent i)e prevented by keeping the bowels o|)en, 1)V not removing the sutures too soon (some think liny ought even to be left in for ten days), and by rej)la('iug them l)y |)laster strips, as recommended al)ove(p. <)."»2). W it hapjx'us, the j)atient should be ane-thetized, and new sutures put in. It may be so diflieult to rej»lace the intestine that it becomes necessary to piuicture it and 670 DISEASES OF WOMEN. let the gas escape. Before replacing it, it should be washed with the normal solution of chloride of sodium. Sometimes a Jistulotis irad loads into the abdominal cavity, and resists healing for a long time. Patients affected with tuberculosis, syphilis, or cancer are predisposed to this untoward accident. In most cases it is due to the mechanical irritation caused by a drainage- tube or suture- and ligature-material. Sometimes the cause is sepsis. It not only protracts convalescence, but may lead to the formation of a fecal or urinary fistula, nephritis, and exhaustion. Many such fistulae heal by nature's sole efforts under favorable hygienic circum- stances, and the use of nourishing food. Daily irrigation with hot water or mild antiseptic fluids, especially the peroxide of hydrogen, contributes, however, much toward a favorable result. Sometimes much time can be saved by dilating the fistulous canal sufficiently to introduce a fine pair of forceps and pulling out a ligature from the bottom (p. 649). Packing with iodoform gauze or marine lint soaked in balsam of Peru is also often useful. Strong fluids and rough ma- nipulations must be avoided, as they may make the condition worse by wounding the intestine.^ In protracted cases the best treatment is to make an incision in the abdominal wall at the opening of the fistula, and dissect out the whole wall of the same, whether it becomes necessary for this purpose to enter the peritoneal cavity or not. A rubber drainage-tube or a strip of iodoform gauze is left in for a fe\v days, then replaced by catgut strands, which contribute to the healing. Fecal fistula is a rare complication. It is due to injury of the intestine during the operation or to pressure from a drainage-tube. It may occur as late as two or three weeks after the operation. The accident may be prevented by enlarging the abdominal incis- ion, if there are many adhesions, and using the elevated-pelvis posi- tion, so as to obtain a view of adhesions that implic.ite the intestine ; by using iodoform gauze as a drain instead of hard tubes ; and by using silk, not catgut, in repairing injury to the intestine. To operate for fecal fistula is dangerous and unnecessary, for, as a rule, it closes spontaneously within a year. The fistula should be tamponed with marine lint soaked in Peruvian balsam, or gauze impregnated with iodoform, aristol, or dermatol, and the dressing renewed daily. AVheu the opening in the bowel becomes very small, the intestines should be emptied by a cathartic, then kept at rest for a week, and then again moved by enemas. When the hole in the intestine is closed the same dressing should be kept up luitil the sinus heals up from the bottom.^ 'A valuable paper on this subject by Andrew F. Currier of New York is found in Annals of GyncEcology, July, 1892, vol. v. No. 10, p. 577. ^ An interesting paper on fecal fistulae after laparotomy by A. Palmer Dudley is found in Amer. Jour. Obst., Feb., 1892, vol. xxv. pp. 145-163. DISEASES OF THE OVARIES. 671 Tetanus is also a rare complication, and the prognosis is very bad. It should be treated with chloroform, chloral, and curare, or a sub- cutaneous injection of a specific antitoxin. Phlebitis occurs sometimes. The affected leg should be raised on pillows, painted with tincture of iodine, wrapped iu cotton batting and slightly compressed whh a roller-bandage. Great care should be taken not to press much on the swollen vein, as a clot may be detached, and cause sudden death by embolism of the pulmonary artery. Parotitis is a rare occurrence. The swelling of the parotid gland may simply be due to the mysterious consensus between that organ and the genital gland, also frequently observed in man. It is then of slight importance, and soon ends in resolution. But it may also be part of a septic infection, and then it has a tendency to suppurate, and is a serious complication. The abscess should be opened at once. 3Iental Aberration. — In rare cases ovariotomy is followed by mania, melancholia, and temporary or permanent insanity. This complication is most apt to arise in patients with an hereditary predisposition. If both ovaries have been removed, menstruation stops, as a rule, but may continue for a few months. (Compare pp. 121 anil 570.) If one ovary has been left behind, pregnancy may occur, and it, as well as the ensuing childbirth, offers nothing abnormal, except that the cicatrice is subjected to such a strain that it needs })rotection by means of an abdominal belt. If lx)th ovaries have been removed, the patient is, as a rule, sterile. (In regard to an exception to the rule and its explanation, see p. 581.) Prognosis. — The technique of ovariotomy has been brought to such a degree of perfection that in the hands of the most skillful o[)erators the mortality has been reduced to 5 per cent. Circumstances that make the prognosis good are a good constitution, a hopeful disposi- tion, absence of disease in other organs, a unilocular (jr j)aucilocular cyst, a good pedicle, and al)sen('e or easy s('j)arability of adhesions. Death is commonly due to shock, hemorrhage, peritonitis, or septi- cemia, to which are added the rarer causes, such as exhaustive sup- puration, uremia, tetanus, or embolism.^ B. So/ id Ovarian Tinnors. Solid ovarian tumors are nuich rarer than cystic tumors of the ovary and solid uterin(! tumoi's. They may be Jibroidfi, papilhyna.'^, .sarcomas, endothetioinas, carfinomas, 6v tubercuhms. ^ 11. C. Coe ha.s in :i most exc< Iloiit paper in Trnm. Avirr. di/n. Soc, 1S,S9, vol. xiv. pp. 170-ini, lia.scd on personal observation, disoussed "Death from Vi.sceral Affections after Ovariotomy." 672 DISEASES OF WOMEN. I. Fibroma. Pathological Anatomy. — Fibroids of the ovary are usually small, not larger than a hen's egg or an orange, but may reach the size of an adult's head, or even become enormous, weighing over sixty pounds. Tiiey are smooth, globnlar, and nodular, like uterine fibroids; but, unlike them, if they do not comprise the whole ovary, they are inti- mately connected with the surrounding tissue, and cannot be shelled out. They may be hard or so soft as to become fluctuating. They are most frequently found on one side only, but may be bilateral. They may be diffuse — /. e. comprise the whole ovary — or circumscribed, occupying only a part of it, and then generally the outer end, while the remainder is in a condition of chronic oophoritis (p. 593). The cut surface shows translucent gray or yellowish places alter- nating with opaque white ones. The follicles have disappeared. The tissue is composed of fine fibrillar connective tissue, peculiarly rich in long spindle-cells. Sometimes it contains smooth muscle-fibers, in other cases none. As a rule, the mesoarium is preserved, forming a pedicle to the tumor, but when this grows large it may invade the broad ligament, and become sessile. The tube is not implicated in the pedicle, unless the tumor becomes very large. The tumors are generally accompanied by ascites, which prevents the formation of inflammatory adhesions as long as they remain small. Sometimes they are found together with myoma of the uterus. They may undergo the same changes as uterine fibroids. They may become cystic, a transformation which is due to the dilatation of lymph-spaces in the connective tissue, so-called geodes, hollows filled with a coagulable serous fluid. Such cystic fibroids are called cystojibromas or fibrocysts. Fibroids may undergo mucoid, fatty, or cancerous degeneration, or become calcified or ossified or cartilag- inous. Internal hemorrhage, suppnration, and gangrene may occur in consequence of torsion of the })edicle or pressure during child- birth. Origin. — The fibroma may originate in the albuginea or in a corpus lutenm.^ Etiology. — The etiology of ovarian fibroids is unknown. They are more common in young women than later in life. Symptoms. — Commonly there are menstrual disturbances, such as amenorrhea, dysmenorrliea, or irregular menstruation. The tumor causes more pain than uterine fibroids. It grows very slowly. As- cites develops frequently and early. If the tumor acquires large ' Those who are more particularly interested in the pathology of ovarian fibroids will find an interesting monograph on the subject by H. C. Coe in the Amer. Jour. Obit., July and Oct., 1882, vol. xv. p. 561, et se^. DISEASES OF THE OVARIES. 673 proportions, all the pressure-symptoms described in speaking of ute- rine fibroids (p. 500) may be developed. As a rule, the tumor is freely movable. Diagnosis. — It may be difficult or impossible to distinguish an ovarian fibroid from o. pedunculated uterine fibroid, unless both ovaries can be felt, which, of coui-se, excludes an ovarian tumor. The ovarian tumor causes more pain. A malignant tumor grows more rapidly. A fibrocyst of the ovary, if not movable, closely resembles a uterine fibrocyst. In the latter the sound will, however, generally show a .greater depth of the cavity. A fibrocyst of the ovary can hardly be distinguished from other ovarian cysts. It may, therefore, often be necessary to perform exploratory laparotomy before a positive diagnosis can be arrivetl at. Progno.s'is. — The tumor may become dangerous by its size. It may op}X)se an insurmountable obstruction to childbearing, and necessitate Cesarean section. It may undergo dangerous changes, as mentioned above. Death may result from peritonitis, nephritis, uremia, intes- tinal obstruction, or an embolus in the puhnonary artery. Treatment. — Electrolysis is said to have caused a diminution of the tumor, but it is not known if the result is permanent. It should only be used if an operation is absolutely refused. The true treat- ment called for is abdominal or vaginal ovariotomy (compare Hyste- rectomy, p. 510), wliich ought to be performed a.s soon as the tumor is found. 11. Papilloma. AVe have seen above (p. 614) that a whole class of ovarian cysts is chanicterized by the presence of papillary growths in the interior, which may perforate the wall, and enter the peritoneal cavity. Simi- lar papillary growths may develop on the surface of a solid ovary or the wall of a glandular cyst. They are, as a rule, accompanied by ascites. They may be small like warts, or become a.s large as a fist, and extend to neighboring organs. Etiology. — Gonorrheal salpingitis has in several cases precedi.d this formation. Prognosi'i. — It has a tendency to become malignant. Treatment. — The treatment consists in early ovariotomy. III. Sarcoma. Sarcoma of the ovary is a rare affection. P<dhol()gic(d Ancdomy. — It may be primary or develop secondarily in an ovarian cystoma. It is often bilateral. It forms pink tuinore ranging in size from that of a child's fist to that of a man's head, or 4.3 674 DISEASES OF WOMEN. may even acquire enormous proportions. It is globular or oval, and lias a smooth surface, with varying consistency according to the com- position, the pure sarcomatous growth and cystosarcomas being much softer than fibrosarcomas. Often small cysts project slightly from the surface. . Like other solid ovarian timiors, it is commonly, and at an early date, accompanied by ascites, which prevents the formation of adhesions. It is rich in blood-vessels, and may become cavernous, forming large cysts. The follicles are destroyed. It may be combined with sarcoma of the uterus. Spindle-celled sarcoma is the most common variety, but round- celled and mixed-celled sarcomas are also found. The variety known as alveolar sarcoma has likewise been observed. The sarcomatous tis- sue may be combined with myxomatous, fibrous, or carcinomatous tissue {inyxosarcoma, fibrosarcoma, sarcoma carcinomatoswii) or a new for- mation of glands (adenosarcoma). The sarcomatous tissue may undergo changes, especially fatty degen- eration, by which hollows are formed without separate walls and filled with a fatty fluid.' A sarcoma may also become calcified. Torsion of the pedicle may lead to internal hemorrhage, suppuration, or gangrene. Etiology. — Sarcoma has been found in new-born children, and is, like fibroids, usually found in young persons. It may develop in a fibroid. Diagnosis. — It grows more rapidly than fibroids, and especially a cystosarcoma may in a short time acquire very large dimensions. Prognosis. — It is a malignant disease, ending in death, which may be due to marasmus, peritonitis, metastasis in other organs, or an embolus in the pulmonary artery. Treatment. — As soon as discovered the growth should be removed by ovariotomy. The danger of relapse is less than with carcinoma. IV. Endothelioma (Ackermann).^ Endotheliomas are malignant tumors which start as a prolifer- ation of the endothelial cells of the blood- or lymph-vcsscls of the ovary. They may acquire considerable size, and have a smooth sur- face studded with tuberosities formed of a brain-like or spongy tissue. In other places is found dense connective tissue. They cannot be diagnosticated from other solid tumors before their removal. Treatment. — Ovariotomy. * I have described a case of sarcoma composed of cysts with transparent walls, formed of spindle-cells, and containing a bloodv fluid, in Amer. Jour. Ohst., 1881, vol. xiv. p. 890 ^ The name has been used in another sense by Dr. Dixon Jones (p. 564). DISEASES OF THE OVARIES. 675 V. Carcinoma. The ovary may be the seat of malullarv, scirrhous, or alveolar (colloid) carcinoma, the fii-st of which varieties is by far the most common. Carcinoma may be primary — that is to say, beginning in the ovary — or secondary, invading the ovary from another organ, especially the uterus. The primary is much more common than the secondary, and may either attack the healthy ovary or an ovarian cystoma, in which latter ca.se the result h ^ carcinomatous cystoma. Any kind of cys- toma, myxoid or dermoid, may undergo carcinomatous degeneration, and the liability to this transformation is even considerable (p. 620). We have seen above that especially the glandular variety is so nearly related to the carcinomatous formation that it may be very difficult to draw the line of demarkation l^etween the two (p. 610). Primary carcinoma forms a tumor varying in size from a hen's egg to an adult's head. It is frequently bilateral. In the beginning the tumor preserves the oval form of the slightly enlarged normal ovary, but later it becomes more globular. It has a nodular sur- face, a whitish color, and varies in consistency from considerable iirmness to brain-like softness (Fig. 360). Fxo. 360. Carciiionift of Ovary. > At fii"st the mesoarium I'orms a pedicle, but later this may become infiltrated, thickened, and hard, and finally the tumor may be entirely sessile. At an early date JLscitic fluid accunmlates, which is often mixed with blood ; local |)eritonitis is of f"re(juent occurrence ; and the dcgcn- ' Photograph of Hi)ecimen from mv operation on Mrs. L., in St. Mark's Hospital on April 12, 1894. ' ' 676 DISEASES OF WOMEN. eration extends to neighboring organs, such as the peritoneum, the pelvic connective tissue, tlie bones, the lymphatic vessels or glands, especially those of the lumbar region, or to the uterus; or metastases appear in the liver, the lungs, the spleen, and other remote parts of the body. It seems that the carcinomatous degeneration originates in an atypic proliferation of the ei)itheliuni of the Graafian follicles or pouches extending from the germinal epithelium into the interior of the ovary (p. 621): Secondary carcinoma of the ovary is brought through the lym- phatics, cancerous epithelial cells being carried into these vessels, in which they cause thrombosis and infection of the surrounding tissue.' Like other tumors, carcinoma of the ovary may undergo secondary Fig. 361. Patient with Carcinoma of Ovary, Ascites, Anasarca, and Marasmus. changes, especially fatty degeneration, which leads to the formation of cystic cavities with ragged walls of carcinomatous tissue — a condi- tion called cydocai'cinoma. Etiology. — Carcinoma rarely attacks the healthy ovary, while, as we iiave seen, it often occiu's in ovarian cystomas. Its cause is unknown. It is found in young women, and even in children, most commonly near the two ends of menstrual activity, puberty or the menopause. Symptoms. — The disease may begin as an acute inflammation or develop gradually. It is characterized by amenorrhea, i)ain, rapid ' This is proved by acttial observation of microscopical specimens from a cantino- matons tumor of the pelvic floor and the ovaries belonging to it, by M. Dixon Jones, Med. Record, March 11, 1893, vol. xliii. ^'o. 10, p. 295, et seq. DISEASES OF THE OVARIES. 677 growth, local peritonitis, ascites, edema of the thighs, and general marasmus (Fig. 361). Diagnosis. — It is clistinguished from fibroid and sarcomatous tumors by the unusually rapid development, greater pain, edema of the thighs, and the presence of tumors in Douglas's pouch, the lumbar region, the omentum, stomach, liver, or spleen. The ascitic fluid accompanying malignant ovarian tumors (carci- noma, sarcoma, or pa]Mlk)ma), obtained by aspiration, contains some- times large round or pear-shaped cells, with a large nucleus, either isolated or in groups.^ Much more conclusive than aspiration is, how- ever, exploratory incision, which enables us to feel the nodules on the tumor, and perhaps on other parts, and to judge whether an extirpa- tion should be attempted or not. Treatment. — If performed early, ovariotomy may effect a radical cure. If the neighboring organs are implicated, it may yet give relief from painful tension for several mouths. But if other tumors are felt beside the ovary, the operation is contraindicated. VI. Tuberculosis. Next to the tubes and the uterus, the ovary is the })art of the geni- tal tract most commonly affected by tuberculosis. It may be primary^ or secondary. It may be part of general tuberculosis, and is then brought to the ovary through the blood, but it may also reach the ovary through the genital canal. Pathological xinatomy. — Miliaiy tubercles are rarely found. The affection may be limited to the surface or invade the whole organ. The ovary is tiien somewhat enlargetl, soft, and contains cheesy de- posits ranging in size from that of a millet-seed to that of a marble. These tuberculous nodules may soften and rupture into tiie })eritoneal cavity, causing peritonitis. The surface of the ovary is commonly covered with layers of inflammatory exudation and adhesions. Syuiptoiiis. — The symptoms are those of chronic oophoritis. l)iagno.'<ix. — The disease can only be diagnosticated, if swelling of the ovary is c(H)ii)ined with pulmonary tuberculosis or local tubei- culosis of the visible part of the genital canal, or if the discharge from the uterus contains cheesy masses and tubercle-bacilli. Treatment. — If the affection is primary, salpingo-o()phorectomy may lead to a cure. If it is combined with pulmonary tuberculosis, and the disease has been checked in the lungs, the removal of the apjx'ud- ages is still indicated. If it is alli<'<l to a siinilai- afleclion of the tube and the lUenis, hvsten'ctoinv niav be added ([>. Aid). I^veu tui)ercular |)eritoiiitis may be cured by the operation. On the other ' (iarri^'it's, Di^ujnoaU of Onifiim f'l/ulK, pp. 9l-it7. " Dr. (i. M. Tutllc of N»'w York lia.s reported !i case of apparently primary tul)er- culosis of the ovary in Amrr. ./nin: OImI., .Jan., IH'.H), xxiii. p. OH. 678 DISEASES OF WOMEN. hand, the operation is contra-indicated as long as the disease spreads in the kings. If no radical cure is possible, the usual medical and hygienic treatment is all we have to rely on. CHAPTER VII. Oophoralgia. The ovary may be the seat of neuralgia. In most cases this forms only part of hysteria, but the disease may be found in women who show no other symptoms of that affection. It may be of malarial origin. The left ovary is affected much more frequently than the right, for which circumstance we may, perhaps, find an explanation in its con- tact with the rectum, the contents of which are apt to press on the ovary on this side, or the different disposition and construction of the ovarian vein on this side (p. 77). Sometimes the affection is bilateral. The pain is spontaneous, or may be produced by pressure on the ovary. It is felt in the hip, shooting back to the lumbar region or down the leg, and is so severe that the patient can neither be moved nor stand. Very often it is combined with hemiansesthesia of the corresponding side and hystero-epileptic seizures. Pressure on the ovary produces, first, cardialgia and vomiting ; next, palpitations, with frequent pidse and globus hystericus; and, finally, often a hissing sound in the corresponding eai', pain in the temple, darkening of the eyesight, loss of consciousness, and convulsions. AVhile pressure on the ovary may produce such an attack, it can also check a spontaneous one. Diagnosis. — In chronic oophoritis the ovary is enlarged, and often uneven and fastened by adhesions. TreaUnent. — The treatment consists in rest, anodynes, galvanism, faradization with the secondary current of high tension (p. 247), and tonic and antihysteric remedies. If the disease is malarial, it yields to large doses of quinine.' Oophorectomy has sometimes a marked beneficial effect, but is in many cases fruitless. Desiccated parotid gland substance (tablets containing two grains each, from tiiree to six tablets daily) is said to have given far more prompt and lasting results than other forms of treatment." ' Case of H. C. Coe, Amer. Jour. Med. Sci., April, 1891, vol. ci. p. 365. 'J. B. Shober, Amer. Jour. ObsL, Feb., 1899, p. 175. Tablets made by Armour in Chicago and Mulford in Philadelphia. PART VII. DISEASES OF THE PELVIS. Under this title we describe the affections of the peritoneum, the connective tissue, and the blood- and lymph- vessels of the true pelvis, including the ligaments of the uterus. CHAPTER I. Ma lform ations. In speaking of the uterus (p. 406) we have mentioned that latero- position is due to an uneven development of the two broad ligaments, anteposition to defective development of the parts situated in front of the uterus, and retroposition to a similar defect in those behind it. Perhaps some cases of congenital anteflexion and auteversion orig- inate in too great shortness of the round ligaments. The peritoneal pouch, which in the fetus forms the ciuial of Nuck, and normally is transformed to a fibrous string, may remain open. It may either remain in connection with the abdominal cavity or be closed at the upj)er end and become the seat of hydrocele, or form a sheath around the round ligament, which must be pushed back in Alexander's operation (pp. 60, 280, and 47 Ij. ClIAPTEIl II. Aneurysm of the Uterine Artery. I AM not aware that more than one case of aneurysm of the ute- rine artery has been reported.' Upon vaginal examination there was found a j)nlsatiiig tumcjr in the ])elvis of the size of a hazehnit, which was (liminisjie<l by pressure, but refilled again each time press- ure was discontimied. It gave; a subjective sensation of thr()l)bing. It was supposed to be due to the use of leeches in the vagina, and might, perhaps, also be due to childbirth. The treatment recom- mended is galvanopuncture, with the positive pole in tiie tumor, or tbrcipressure. ' Mars, Exrcr,,(a MMua. No. 2, Nov., 1891. 679 680 DISEASES OF WOMEN. CHAPTER HI. Diseases of the Broad Ligament. A. Varicocele of the Broad Ligament, or Parovarian Varicocele. Varicocele in the female corresponds to the same condition in the male, but tiie different anatomical relations constitute rather consider- able differences between the two. While in man the veins of the testis follow an almost perpendicular coui'se, those of the ovary are nearly horizontal. The spermatic veins soon form a sinjjjle trunk, whereas the pampiniform plexus in woman communicates freely with the uterine, the vaginal, and the vesical ])lexus. There will, therefore, be less tendency to the disease in woman than in man. As a matter of fact, it is about three times less common in female cadavers than in male, and is rarely recognized in the living subject, although we may be sure that the swelling must have been much larger during the patient's lifetime than after death. By varicocele we do not mean the enlargement of veins in tiie broad ligament which accompanies tumors, especially uterine fibroids, but an isolated swelling of the ovarian veins, implicating more or less the other veins of the broad ligament. It has been divided into supe- rior ])arovarian varicocele when it is situated between the ovary and the tube, and inferior parovarian varicocele, when it is found below the ovary. It may reach the size of a hen's egg, and is composed of a conglomeration of veins, the walls of which are often thickened, and which may contain phlebolitlis. It is much more common on the left side, but may be found on the right or on both, the preponderance on the left side being without doubt due to the lack of a valve in the left ovarian vein, and to the fact that it opens at right angles into the renal vein (p. 77). Etiolof/j:/. — The condition is probably due to subinvolution after confinement ; a relaxed condition of the tissues following a low state of the general health ; an original weakness of the walls of the veins ; pressure from fecal accumulation in the sigmoid flexure, which lies in front of the ovarian vein ; or displacements of the uterus, esjiecially retroversion and retroflexion, whicii interfere with the free return of the blood through the infundibulopelvic ligament. Symptoms. — The most prominent symptom is pain of a ]>eeuliar dull, aching character, extejiding up the side to the region of the kid- ney. The pain disappears when the patient is in the horizontal posi- tion, and is increased by standing erect. By bimanual examination with one finger in the rectum a distinct doughy tumor or knotted swollen vessels may be felt in the broad ligament. Prognosis. — Some patients suffer so much that they are unable to stand or walk, and are bedridden invalids for years. The dilated veins may rupture, and form a hematocele or hematoma (see below). DISEASES OF THE PELVIS. 681 Diagnosis. — Salpingitis causes a sausage-shaped tumor ; oophoritis is harder and more painful ; cellulitis and pelvic peritonitis have more diffuse contours, and none of them becomes smaller in the recumbent position. A swollen vein may be confounded with a swollen ureter, but in the latter condition other symptoms of a pathological state of the uropoietic organs are present. Treatment. — If the condition is recent, hot douches, tincture of iodine, ichthyol glycerin, or faradic electricity, combined with frequent rest in a recumbent position and attention to the bowels, may effect a cure. If it is old enough to have produced ])ermanent dilatation of the veins and thickening of their walls, nothing is likely to be of avail except an extirpation of the affected part of the broad ligament, together with the tube and ovary ; which may be done by tying it with the cobbler's stitch or some other form of a chain-ligature, and cutting the parts away above the ligature.^ B. Ci/sts of the Broad Ligament. Xot every cyst situated in the broad ligament is a cyst of the broad ligament. We have seen above (p. 619) that ovarian tumors may develop downward into the broad ligament and even far beyond its base. A Graafian follicle or a corpus lutcum may form such a cyst. By a cyst of the broad ligament is meant a cyst developed in the broad ligament outside of the ovary. Such cysts arc sometimes called parovarian cysts, but this name is not quite correct, for the parovarium is a definite organ found in a definite locality, and, if it is true that sudi cysts may develop in it, it is no less true that they may develop in any other pail of the broad ligament. The schematic figure .362 gives a good idea of the locality of such cysts. Cysts of the broad ligament are much rarer than ovarian cysts. As a rule, they are monocystic, but exceptionally })()lycvstic tumoi-s of this origin have been found. Commonly, they do not exceed the size of a pregnant uterus at six months' gestation, but exceptionally they may become enormous. As a rule, the wall is so thin as to be translucent or transparent, but in exceptional cases the cyst may look like a uterine growth on account of a thick layer of smooth nuiscle-fibei's. The wall is com- posed of the j)eritoneum with its endothelium; a layer of connective ti&sue containing sonic plain muscle-fibers; often glands, which do not ojicn into the interior; and very few blood-vessels, which gives it u ' Tlie (lisca'^c has been dt'scrilu'd, with report of fmir rasos in wliicli laj)ar()tomy %vas |MTforinc<i Hiicccs^fuliy, hy A. I'. Dudley of New York in tiie X. )'. M(<l. Jour., Ann. 11 and is, ISSS — a j)a|)er tliat lias heeii srvcnly, and in my ojiinidu ratlier unjiiHtly, criticisefl by Coe in Amfr. Jour. Ohsl., May, ISS't. vol. xxii. ]>. 501. 1 have nivseir()j)erate(i on a ea.se ot'tliis kind— Mrs. JI., St. .Mark's Hospital, l"el). 1!», 1S".»4. The left broad ii),'aineiit tornieii a eon^donieralioii of torlnous dark bine, almost black vein.H, eacli as thick as a lead pencil, situated between the uterus and the tube. 682 DISEASES OF WOMEN. white color. Its interior surface is smooth or wrinkled, but has no glandular formations, and is covered with a single layer of vibratile, low columnar or flat epithelium. As a rule, these cysts extend right up to the tube, that becomes imbedded in the wall without mesosal- pinx. Like ovarian tumors, they may develop below the broad liga- ment, and lie below, in front of, or behind the peritoneum. They may become so large as to be much more abdominal than pelvic tumors. Diagram of the Structuresinandadjacentto the Broad Ligament (Doran) : 1, framework of the Eareut'hyma of the ovary, seat of 1 a, simple or glandular multilocular cyst; 2, tissue of ilum with 3. papillary cyst 1; 4, broad-ligament cyst independent of parovarium and Fallo- pian tube : r>, similar cyst in broad ligament, above the tube, but not connected with it; 6, similar cyst developed close to 7, ovarian fimbria of tube; 8, the hydatid of Morgngni; 9, cyst developed from horizontal tube of parovarium ; 10, the parovarium: the dotted lines represent the inner portion, always more or less obsolete in the adult; 11, small cyst devel- oped from a vertical tube : 12, Gartner's duct ; 13, track of the same in the uterine wall. The Jlilid is normally watery, nearly colorless, and alkaline or neutral. It does not coagulate spontaneously, nor to any extent by heat before adding an acid. It contains a few cells and Bennett's laro;e and small corpuscles (Figs. 331, 332, and 338, pp. 611, 612). But in exceptional cases a thick colloid fluid has been found in such cysts. Papillary and dermoid cysts may also develop in the broad ligament. As a rule, cysts of the broad ligament are sessile, but sometimes the ligament forms a pedicle, which may even become twisted, an accident that may lead to gangrene of the tumor. These tumors are found in the period of sexual maturity. They grow very slowly.' They do not impair the general health, and give rise to no symptoms except by their bulk. * This theory of the origin of these ovarian cysts is not generally admitted. ■•"Many years ago I assisted in aspirating one that had been tapped five years before by W. L. Atlee, and in that tinie had not become larger than the uterus at the end of six months' gestation. DISEASES OF THE PELVIS. 683 Diagnosis. — A small cyst of the broad ligament may be felt in the t)elvis separate from the ovary and tilting the uterus over to the opposite side. It may be so like hematoma that it cannot be distin- guished from it except by the history, the latter developing rapidly, and being reabsorbed after some time. The distinction from ovarian, especially intraligamentous, and other abdominal cysts may be veiy difficult. The leading points are the slow development, slight pain, absence of cachexia, the low seat, absence of solid masses, a very dis- tinct fluctuation-wave, flatness in front, and greater fullness in the flanks. It is impossible to tell for sure, by the fluid alone, whether a tumor is ovarian or a cyst of the broad ligament, although the presumption may be strongly in favor of one or the other ^ : both ovarian cysts and cysts of the broad ligament may have serous or colloid contents, but the latter is common in ovarian cysts, rare in extra-ovarian, while the watery is common in extra-ovarian, rare in ovarian cysts. Still, it may be found, not only in true monocysts, but in multilocular cystomas of the ovary. Treatment. — Small tumors of this kind should be let alone. When by their bulk they become troublesome, the best thing to do is to re- move them exactly like an ovarian tumor. Sometimes there is a pedicle, and sometimes one can be made of the peritoneal covering during the operation. Enucleation is, as a rule, easy. If it meets with difficul- ties, the sac should be cut open and the left hand introduced to help the right hand separate the cyst from the peritoneum. After the enu- cleation the empty shell may be tied as a j)edicle in one or more sec- tions, or the edges may be stitched together with catgut, or they may be brought together as a purse and fastened to the abdominal wound. The cavity is j)acked with iodoform gauze, and will fill by granula- tion, l)ut, as a rule, only with suppuration. If the tumor cannot be enucleated, the whole sac may be fastened to the abdominal wound [rnarsiijjid/irjifion). Redundant tissue is, of course, cut away in all these procedures. Anotlier way of operating is simply to cut out a large circular piece of the wall and close the abdomen. These cysts used to be treated by tajjpinr/ or aspiration, and their innocuous nature and the slowness to refill of most of tliem are indeed great indu<'ements to use that kind of treatment ; but since it has l)eeu discovered that some of them are papillomatous, and the radical ope- ration in most cases easy and siife, extirpation is preferred by most gynecologists. It' the ovary and tube are healthy and j)!acetl so that they need not be removed, they should be left behind. Of late the total extirpation or partial resection of the cyst by the 'Garrigues, iJiaijnoxiK, etc., j)p. 49-56. 684 DISEASES OF WOMEN. vaginal route has been recommended.* Small tumors of this kind can easily be removed by anterior colpotomy, but as to large tumors the writer feels the same hesitation as expressed (p. 641) in regard to the extirpati(m of adnexial tumors by Pean's method. \Ve must bear in mind that those who invent or are particularly identified with a cer- tain method incline to give it the widest possible range of application. C. Solid Tumors of the Broad Ligament. Besides uterine fibroids which grow in between the layers of the broad ligament, and of which enough has been said in speaking of that disease, the broad ligament is occasionally the seat of solid tumors which take their origin in the ligaments themselves. Thus, myomas, fibromas — sometimes melting to fibrocysts — lipomas, and sarcomas, have been observed. Such tumors may push the vagina before them and protrude into the vulva, or grow out through the greater sciatic foramen, simulating a hernia. All solid tumors of the broad ligament should be removed by laparotomy as soon as discovered. CHAPTER IV. Diseases of the Round Ligament. In an earlier part of this work (p. 274) we have said that any part of the round ligament may become the seat of a fibroma, and that this occurs more frequently outside than inside of the pelvis. The fibrous tissue is commonly blended with muscular, myxomatous, or sarcomatous tissue, constituting a myofibroma, myxofibroma, or fibrosarcoma. In one case the lymphatics were much distended [fibroma lymphangiectodes) . The affection is much more common on the right side than on tlie left. The diagnosis may be very difficult. The treatment consists in early extirpation. CHAPTER V. Diseases of the Sacro-uterine Ligament. We have seen above (p. 459) that inflammation of the sacro-uterine ligament is a chief cause of anteflexion of the uterus. One or botli ligaments are swollen, tender on pressure, and become shortened through cicatricial contraction. The usual antiphlogistic treatment, especially ichthyol glycerin, tincture of iodine, hot douche, and tiie galvanic current, is indicated. DISEASES OF THE PELVIS. 685 and often yields good results in fresh cases ; and even a chronic short- ening may be overcome by means of vaginal packing (p. 182). Since these ligaments form the chief support of the uterus (p. 55), their loss of tonus and elonf/ation, usually due to childbirth, are prin- cipal factors in the production of prolapse of the uterus (p. 478). The loss of tonicity may perhaps l)e remedied by the use of the faradic current or massage. If not, recourse must be had to pessaries, sup- porters, or the operations indicated for prolapse (p. 481). CHAPTER VI. Pelvic Hemorrhage. Internal hemorrhage from the genitals and the parts near them takes place in three ways, differing widely from one another as to fre- quency, anatomy, danger, and treatment, and which it is, therefore, appropriate to designate by three different names and to describe apart from one another. Since, however, most authors follow a different coui*se in tiiis respect, it is necessary to add the other names under which the described conditions are known. The blood may be poured freely into the peritoneal cavity. We call this simply intrajjeritoneal hcmorrliagc, but most writers class it with the se(;oud condition, and call it non-encysted hematocele or cataclysmic hematocele. Secondly, the blood may enter the peri- toneal cavity, and become limited by inflammatory exudation, so as to form a tumor. We call this lieinafocclc, but it luis been designated as pelvic hematocele, intraperitoneal hematocele, or true hematocele (always comprising the free intraperitoneal hemorrhage). Finally, the extravasated blood may be situated in the connective tissue of the broad ligaments, the ])elvis, and the abdomen. This condition we designate as henidfoinft, but it is also called extrnperitoneal hematocele, false iiematocele, pseudohematocele, or thrombus. (( "oinpare Throm- bus of the Vulva, p. 295.) ^ A. Intra prritoncal Ilcmovrliage. If a large amoinit of blood is j)oured nipidly into the healthy peri- toneal cavity, it meets with no resistance, tin; intestines are pushed asid(,', and the abdominal wall becomes distended, J'Jfiofof/if. — Most cases of abdominal hemorriiage are traumatic and due to rupture of" the liver, or they may be caused by the rupture of an aneurysm of" the aixlominal aorta or the celiac axis. In gyneco- ' Rf)SfnwaHscr of < 'levcl:in<l, ( )hi(>, unites the two last condition, under the name of circiimsrrllxfl or litiiitcd, hiinitnluii/r, opposed to tlie lirst, whieh lie ealLs fr<x linnai- rhage [Trans. Amer. Obnldriciurui and (•'i/necoloyi.fl.", iS'J.'Jj. 686 DISEASES OF WOMEN. logical practice they are nearly always brought about by tubal preg- nancy with, or oftener without, rupture of the tube, and sometimes by rupture of a tlilated vein, such as those forming a varicocele or accompanying a uterine fibroid, or by hemorrhage from a badly secured pedicle, or by adhesions torn during laparotomy. Symptoms. — The condition is characterized by sudden pain in the abdomen ; a sensation of a warm internal current ; faintness ; nausea ; vomiting ; a frequent, small, or imperceptible pulse ; a subnormal tem- perature ; difficult respiration ; pallor; a cold, clammy skin ; and often discharge of blood from the vagina. Consciousness is preserved and the ])atient feels that she is dying. Diar/nosis. — We have only these rational symptoms of internal hemorrliage to go by. No tumor can be felt, and we cannot wait for a dull percussion-sound or the feel of fluctuation. Prognosis. — The condition is absolutely fatal unless the hemorrhage is arrested by surgical means. Treatment. — Tlie indication is the same as for any other serious hemorrhage accessible to the surgeon's knife : laparotomy offers the only chance of rescue for the patient. Clots, fluid blood, and foreign substances, such as a fetus, must be removed from the peritoneal cav- ity, bleeding vessels tied, or diseased appendages removed on the affected side. It is even recommended, in cases of a ruptured fetal sac, not only to stitch up the tear in the tube, but to combine with it the ligation of both the ovarian and uterine artery in their continuity. B. Hematocele. Hematocele is an encysted effusion of blood in the peritoneal cav- ity of the pelvis. Pathological Anatomy. — As a rule, the blood is found in Douglas's pouch, but if the amount is large, it rises more or less above the brim of the pelvis, and may reach as far up as the umbilicus. At first it lies behind the uterus, and is, therefore, called a retro-uterine hematocele. If later it surrounds that viscus, it is designated as circumuterine. If Douglas's pouch is closed by adhesions, the blood accumulates in front of and above the uterus, which condition is named ante-uterine hematocele, and is, of course, much rarer than the otiier varieties. The blood is at first pure and thin, but becomes coagulated, in- spissated, tarry, and, still later, sometimes mixed with pus or sanies. Through adhesive peritonitis the intestinal knuckles are glued to- gether, and plastic lymph is poured out and converted into tissue, forming a roof over the extravasated blood, which roof in places is finger-thick and shuts it off from the peritoneal cavity. ^ Paul Segond, Revue de Gynecologie et de Chirurgie abdominale, 1897, No. 2, p. 235. DISEASES OF THE PELVIS 687 The blood may be derived from the ovaries, the tubes, the uterus, the broad ligaments, the peritoneum, or a fetal sac. If it is a case of tubal preguaucy, the fetus is found only in a small minority of cases, which shows that it becomes absorbed ; but on microscopical examination we always find villi chorii, which are entirely characteristic of an impregnated ovum. Sometimes peritonitic adhesions exist before the hemorrhage takes place, or repeated hemorrhage may occur under the already formed roof. Etiology. — Hematocele is a rather mre disease. It is found at the age of sexual maturity, most frequently in persons between twenty-five and thirty-six yeai'sof age. We may distinguisli two chief forms, of which one is brought about by rupture of some organ, while the other is due to menstrual fluid entering the peritoneal cavity through the abdominal ostium of the tube. By far the most common cause is a tubal pregnancy rupturing into the peritoneal cavity. Hematosal- pinx is more apt to cause fatal hemorrhage in rupturing than the formation of a tumor. Hemorrhagic salpingitis may furnish the blood. There may be closure of the uterine end of the tube or atresia of the uterus or vagina. In rare cases the hematocele is caused by bleeding from an apoplectic Graafian follicle or a hematoma in the stroma of the ovary (p. 587). A hematoma of the broad ligament may secondarily burst, and ])onr its contents into the peritoneal cavity. A ruptured vein is more likely to cause a speedily fatal hemorrhage. Torn peritonitic adhesions may cause hematocele — e. g. when an adherent retroflexed uterus is forcibly replaced (p. 468), or the adiie- sions may give rise to a bleeding in their interior by the same process as that which in ])achymeningitis leads to the formation of a hema- toma of the dura mater. This condition is called hemorrhagic pachi/- peHtonitis. The formation of a hematocele is often closely allied to menstrua- tion. It is not only when the genital canal is closed that regurgita- tion takes place, but lifting of heavy weiglits, violent exercise, coition, and exposure to cold during the menstrual period may have the same effect. Systemic diseases, sucii as scarlet fever, small-pox, purpura, and icterus gravis, may cause such changes in the composition of the bloo<J, and weaken the walls of the pelvic blo<xl-vftssels so much, that tliey give way and allow the bkxKl to escape into the peritoneal cavity. Hyiajdomx. — Sometimes there are premonitory symptoms. Jf the hematocele be due to ovarian or tubal disease, there will, as a rule, be a history of dysmeuorriica and ])ain in the pelvis. If the genital canal is cIose<l, the patieut has never menstruated, or at least not for a long time, and may have had monthly molimina. In extra-uterine pregnancy there may be signs of pregnancy, expulsion of decidua, and 688 DISEASES OF WOMEN. previous attacks of pain. Metrorrhagia or menorrhagia may have been present as a sign of some abnormal condition of the internal genitals ; or the patient may recently have gone through one of the above-named systemic diseases. In other cases the onset may be sudden and without warning. How severe it will be depends on the amount of blood that has extravasated, and the rapidity with which it escapes. There is always a sudden pain in the pelvis, to which may be added faintness, nausea, vomiting, a more or less rapid and weak pulse, and swelling of the abdomen, due to tympanites. Instinctively the patient avoids all movements, and lies, as a rule, on her back. If she is menstruating, the flow may stop, or, ou the other hand, outside of the menstrual period there may come a bloody discharge from the vagina. This stage of hemorrhage is followed the next day by one of inflanmiatory reaction, with a chill, a pulse beating 100 to 140 a minute, and a temperature of 102°-104° F. But this stage is like- wise of short duratiou. As soon as the fluid is well encysted pulse aud temperature return to the normal standard, and the pain abates. The third stage is that of absorption, in which the coagulated and inspissated blood is gradually liquefied and taken up into the circu- lation. Only in exceptional cases suppuration or septicemia super- venes. If rupture occurs, the contents are most frequently evacuated through tiie rectum, more rarely through the vagina, and still more so through the bladder. They may also enter the free peritoneal cavity. During the time of resorption there is often a discharge of thick, dark blood from the vagina, which probably is some of the extravasated blood that finds its way out through the tube and uterus, while others think it is of uterine origin and due to hyperemia. If the amount of blood in the peritoneal cavity is large, it may give rise to pressure-symptoms, such as constipation, retention of urine, tenesmus, uremia, neuralgia, edema of the legs, and rarely phlebitis. Sometimes jaundice is developed, and the urine contains urobilin, causing green fluorescence when chloride of zinc in ammo- niacal solution is added. By vaginal examination at first a soft mass, and later a tumor, is felt filling Douglas's pouch and extending more or less upward toward the umbilicus. The examination is best made with one fing-er in tiie rectum, one m the vaguia, and the other hand on the abdomen. Parts of the tumor may be hard and others fluctuating. It bulges with a round end into the vagina, which, as well as the vaginal portion, may be seen to be in an anemic condition. The uterus is pushed for- ward and upward against the symphysis. By means of the sound it can be ascertained that the fundus lies upward and forward. If Douglas's pouch was closed before the attack, the tumor is situated in front of the uterus, and tilts it backward against the sacrum. If DISEASES OF THE PELVIS. 689 it was partially closed by adhesions, the lower end of the tumor is irregular. In the cachectic form of hematocele the bleeding may take place slowly, and in certain cases, depending on menstruation, there may be a monthly exacerbation, with increase in the size of the tumor. Diagnosis. — The diagnosis is, as a rule, not difficult. • The general condition is not so alarming as in unlimited intraperitoneal hemor- rhage. Hematoma does iiot form so large a tumor, is not accom- panied by vaginal discharge or peritonitis, is lateral and pushes the uterus over to the opposite side, and is absorbed sooner. Pelviperito- nitis is ushered in with fever, while in hematocele it comes a day later. The well-defined tumor is formed later in peritonitis. It is often situated more laterally. The exudation remains fluid longer. But in the last stage it may be impossible to distinguish them. A retrofiexcd gravid uterus is accompanied by signs of pregnancy, a peculiar elasticity of the body of the uterus, softness of the lower uterine segment and the cervix, and a distinct angle between the two. Extra-uterine pregnancy is accompanied by signs of pregnancy, and is rarely developed in Douglas's pouch. As we have seen above, the two are frequently combined. Prognosis. — The prognosis is nmch better than in cases of free hemorrhage. Most patients recover if not interfered with, but the process is a slow one. Absorption takes from three weeks to six months. Some succumb, however. The rupture into the peritoneal cavity ends speedily in death from shock or septic peritonitis. After rupture through the rectum suppuration may continue and slowly ex- haust the patient's vitidity. Treatnund. — During the first stage the indications are to arrest hemorrhage, ('()ml)at shock, and relieve pain. The patient should be moved as little as possible; her head should be low; bottles with hot water should be applied to the extremities; morphine should be given hypodermically, and brandy by tiie mouth. An ice-bag should be placed over the symphysis, and ice- water injected into the vagina and rectum, unless the vitality is low, when very hot water is to be preferrc<h In \\\(i inflammatory stage ice-bags, hot-water injections, and opium are indicated. In the third stage absorption sjiould l)c promoted by the use of Priessnitz's compress (p. 195), ichthyol, iodine (internally and exter- nally), merciuy ointment or j)laster, and the galvanic current, with a large negative pole in the; vagina and Kngelmann's electrode (p. 248) on the abdomen. The vagina should l)e l«'j)t clean by means of an- tise|)tic injections, in order to avoid ])()>sil)l(' inf(>(!tion. In fresh cases all operative intcsrfi'rence is ai)S()huely contra-indi- cated. If there is any likelihood of a fluid collection in tiie pelvis 44 690 DISEASES OF WOMEN. being a hematocele, the doctor should abstain even from a puncture with a hypodermic syringe. Even it' his instrument is aseptic, and he disinfects the vagina, germs of suppuration and putrefaction may enter into this mass, which is so particularly favorable for their prop- agation, and cost the patient her life. If, on the 'Other hand, softening of the tumor, with high tempera- ture, frequent pulse, dry skin, chills, and pain in loins and legs denote that suppuration has taken place, an opening should be made in the vagina large enough to introduce one or two fingers ; the sac should be emptied and washed out with antiseptic fluid, and a finger- thick T-shaped soft-rubber tube introduced. If there is any bleed- ing, the cavity is })acked with iodoform gauze for forty-eight hours before using the tube. The end of the tube is surrounded with iodo- form gauze and rubber tissue, and the vagina packed loosely with gauze, Once or twice a day mild antiseptic injections are made through the tube (thymol is particularly appropriate on account of its bland ness). The incision in the vagina may be made in the median line, where there is the least chance of wounding vessels and the accumulated blood keeps the rectum away ; but of late most operators prefer a transverse incision just behind the cervix (p. 511). If the blood-cyst has ruptured into the rectum, and suppuration continues, exhausting the patient, it is best to make a counter-opening in the vagina and insert a drainage-tube. The sac may be so thick and stiff that a soft tube is compressed. Then it is necessary to have one of hard rubber closed with a stopcock. A nother indication for operation is a very slow absorption. If the collection is large, and at the end of a month no perceptible diminu- tion lias taken place, the patient may be spared the annoyance of spending many months in bed by evacuating the contents of the sac. Operation is also indicated in repeated rela]>ses. As in such a case we may expect some bleeding, the sac should be tightly packed with iodoform gauze, M'hich may be left in for a week. Vaginal incision is much safer than abdominal, on account of the danger of septic peritonitis in the latter. But if the extravasation cannot be reached from the vagina, laparotomy is indicated. The in- cision may be subperitoneal or transperitoneal. For the former an incision is made above and parallel to Poupart's ligament, the peri- toneum lifted up, and an incision made into the sac without opening the peritoneal cavity. If this is accidentally opened, the opening shonld be enlarged and tamponed with iodoform gauze for twenty- four hours, until adliesions have formed. Then the gauze is removed and the tumor opened. The cavity once emptied, a counter-opening is made in the vaginal vault and through-drainage established. Transperitoneal laparotomy is performed in the median line. If DISEASES OF THE PELVIS. 691 possible, the sac should be stitched to the abdominal wall, and drainage established in that way ; but often it is impossible because there is no separate wall. Then we can only wash the cavity out with an anti- septic solution, and drain with iodoform gauze through the wound in the abdominal wall. C. Hematoma. Pelvic hematoma, or hematoma of the broad ligament, is an effusion of blood in the pelvic connective tissue above the levator ani muscle, most frequently between the layers of the broad ligament, whence it may extend under the pelvic peritoneum, up under the abdominal peritoneum, and down on tiie side of the vagina.^ Pathological Anatomy. — The blood is situated in the loose connec- tive tissue between the two layei's of the broad ligament and between the peritoneum and the underlying fascia. In most cases it is not a very large collection, but the sac may contain several pints of blood, and form a tumor that nearly mounts to the umbilicus. As a rule, it is unilateral, but both sides may be affected, and then the two lateral tumors are united by an isthmus in front of and beiiind the uterus, and the rectum is narrowed by a ring-shaped stricture. The flow is arrested by the resistance offered by the surrounding sac, and the blood does not coagulate so rapidly as in hematocele. There may develop some peritonitis, but less than in hematocele. The sac may rupture, Mith the formation of a secondary hemat(x;ele, or it may suppurate, so as to become a pelvic abscess. (See Cellulitis.) Etiology. — Since the connective tissue of the |x?lvis becomes laxer by pregnancy, multiparous and pregnant women, as well as pucrperae, are more apt to l)e affected. A varicocele or the fetal sac in tubal preg- nancy may rui)ture in such a place that the blood escapes between the layei's of the broad ligament, and not into the peritoneal cavity. Ex- cessive coition may be the exciting cause. The accident ha])i)ens most frequently during menorrhagia or the pseudo-menstruation fol- lowing 0('>phorectomy and ovariotomy. The patient may be in j)erfect hetilth. Symptoms. — Suddenly the patient feels ])ain in the ])<'lvis, with faintness and rapid, small j)ulse, but the attack is less alarming tiian in hematocele. The vagina, and even the skin, may have a bluish color. A doughy tumor is felt on one side of the uterus, which it ])ushes over to the opj)osite side and upward. If the affection is bilateral, the uterus is lifte<l up. The tumor is in close comiection with the uterus, ' Acforfling tf> W. A. Freiind (Gyii'ikoloifi.'^chf Klinik, Strasburp, 1885, vol. i. p. 21tM till" pt'Ivic liomatoiiia may in iioii-piierperal cases form lu'twecn tlie rcftiim and the vapina, and in pufrpcral cascH exItMid fmm tlie sides of the vatfina to the ante- rior alulominal wall, the kidneys, and into tlie mesentery, vilhout enlirinc/ the broad liyamenl. 692 DISEASES OF WOMEN. which is rendered immobile. As a rule, the tumor does not rise beyond the pelvic brim, but it may, as stated above, ascend to the neighborhood of the umbilicus and be distinctly fluctuating. Diagnosis. — The etlusion is less rapid, causes less pain and shock, and forms a distinct tumor sooner than in hematocele. In large bilat- eral collections in the connective tissue the upper surface is convex, the lower more or less irregularly concave, so that the whole reminds one of a jellyfish, while hematocele bulges into the vagina with a con- vex end like a dilated bag. The ring-shaped stricture of the rectum is characteristic. The tumor is found just within the vulva, while in most cases of hematocele its base is situated higher up. It is found on one or both sides of the vagina — in hematocele, behind. It re- mains longer fluid. The uterus is sooner rendered immobile. Fever sets in later. In cellulitis the fever precedes the formation of the tumor, the uterus is not immobilized so soon, and the inflammation is referable to childbirth, abortion, or operative interference. Proc/nosis. — Xearly all patients recover in from ten to fourteen days. Only when occurring in pregnancy, childbirth, or the puer- perium is it dangerous. As a rule, the blood, and even the fetus in extra-uterine pregnancy, is absorbed. Suppuration is rare. But the sac may rupture into the peritoneal cavity, and in extra-uterine preg- nancy the fetus may continue to grow. Treatment. — As a rule, no operation should be performed, but the same measures be adopted as for hematocele. If the bleeding is severe or the tumor very large, and does not become absorbed, or is changed into an abscess, one of the operations described under Hema- tocele should be performed. In laparotomy the sac, if possible, should be stitched to the abdom- inal incision, but it may be so brittle that it cannot be lifted so far even when pressure is made against the vaginal roof. In such cases the uterus may sometimes be used to fill the gap. A suture is carried tlu'ough the abdominal wall, the edge of the sac, the peritoneal cover of the uterus, the other edge of the sac, and the otiier side of the abdominal wall. If it appears desirable, a second suture may be inserted in a similar way. When these sutures are drawn taut, the sac is closed by the uterus, and the latter brought in contact with the abdominal wall.^ Galvanopuncture through the vagina, with a fine platinum-pointed needle connected with the positive pole, and with a current of 50 milliamperes, used from five to ten minutes, has been recommended. In a small hematoma one application suflices; in larger it may be repeated in from three to six days.^ * Marcus Rosenwasser of Cleveland, O., Annals of Gynecology, March, 1891, vol. iv. p. 3-2o. 2 A. H. Goelet, N. Y. Med. Record, March 8, 1890, vol. xxxvii. p. 279. DISEASES OF THE PELVIS. 693 CHAPTER VII. Perimetric Inflammation. By " perimetric inflammation " is undei*stood the inflammation of the pelvic j>eritoneum, tiie pelvic connective tissue, the veins, and the lymphatic vessels and glands in the pelvis. On account of the inti- mate connection between these different structures and Avith the neighboring organs, it is quite common that more than one of them is affected at a time, and it is evident that there must be a cer- tain similarity between all pelvic inflammations; but according to the tissue from which the inflammation starts or tiie one that is most affected we distinguish perimetric inflammations by different names, and these different diseases present also sometimes peculiarities as to frequency, physical signs, prognosis, and indications for treatment. Our old knowledge, based only on clinical observations and ])ost-mor- tem examinations, has been greatly extended and corrected by the numerous laparotomies that have been performed in these conditions. Thus we describe separately pelvic peritonitis, pelvic cellulitis, pelvic lymphangitis, and pelvic phlebitis. A. Pelvic Peritonitis. Pelvic peritonitis is the inflammation of that part of the peritoneum which covers more or less of the uterus, the tubes, tlie bladder, the rectum, the vagina, and the walls of the pelvis, and which forms the broad ligaments. Pelvic peritonitis is sometimes called perimetritis as a companion name to parametritis, which is used to designate inflammation of the connef;tive tissue ; but since these names are not very characteristic in regard to their derivation, — jicri meaning "around," and j>«;-a, " at the side of," — since their sound, especiially in Englisii, is so much alike that there is little for the memory to take hold of, and since most excellent treatises have been written about them under their old names, we take it to l>e more practical to j)reserve the woi'ds " peri- tonitis" and " cellulitis," although the latter leaves much to be desired from an etymological stan(lj)oint, being a combination of a I>.atin root and a Greek suflix, and tiic root itself being a remnant from the time when what we now call connective tissue was di'sjgnated as cellular ti.s.sue. Of all the j)erimetric inflammations, peritonitis is In- far the most common. Patholof/ical Annfoini/. — Different forms of ])elvi(' pei'itonitis hnve been distingin'shcd — nanx-ly, the serous, the (id/iesive, and the snpjni- ratire — which arc sonietimcs only dilTcrcnt stages of the .same disejise. The inflammation mav be acute or chronic. 694 DISEASES OF WOMEN. In nearly all these eases are found diseased tubes, and usually the ovary is implicated. Often the inflammation of the tubes can be traced back to the corresponding condition in the uterus. Fii'st the peritoneum becomes injected, its endothelium is lost, and serum is secreted from the denuded surface. The neighboring organs are agglutinated by a yellow fibrinous mass that becomes organized, and forms a false membrane which encapsulates the serous exudation. Serum may also be enclosed in the meshes of the adjacent connective tissue, forming an inflammatory edema. The serum may gravitate down into Douglas's pouch or be found in one of the para-uterine foasse, or the quantity may be large enough to fill the whole pelvis, and even surmount the iliopectineal line. As a rule, the fluid is found behind the uterus and pushes it forward, sometimes also to one side, but in exceptional cases the uterus being already bound down with adhesions, the fluid is found above and in front of it. Later this serum in the peritoneal cavity becomes inspissated, form- ing a yellow mass like orange-jelly,^ the more watery part being reabsorbed and connective tissue being formed. Finally, the whole may be absorbed, or, as it is called, the disease ends in resolution. Even solid adhesions can probably disappear without leaving any trace ; at least a uterus that at one time is immovably moored to the surroundings may regain entire mobility. This absorption is doubt- less favored by the constant movement in which the pelvic organs are kept by respiration, the different degrees of fullness of the bladder and intestine, their evacuation, sneezing, coughing, muscular exer- tion, and sometimes an intervening pregnancy in which the adhesions are softened and stretched. But, as a rule, adhesions remain indef- initely. The serous cyst may remain unchanged for many months. Sometimes the contents become bloody in consequence of rupture of vessels in the adhesions, and in rare cases they become purulent. In the adhesive form we find on one or both sides of the uterus a tumor composed of the tube, the ovary, and, perhaps, a knuckle of intestine or a part of the omentum, all matted together with plastic lymph or organized adhesions. As a rule, this mass is bound in the same way to the posterior surface of the broad ligament, or, more rarely, to the posterior surface of the uterus, the anterior surface of the rectum, the sui)erior surface of the bladder, or the pelvic wall. Serum may ex- travasate into such a mass. The ovary is covered with a false membrane. The tube is contorted, and its sinuosities bound together ; the abdominal ostium is often closed ; the fimbriae may have grown together ; bands of adliesions form constrictions which cause adhesive salpingitis and strictures or total partitions in the interior of the tube. The uterus may be retroflexed or retroverted, and bound to the rectum, or, more rarely, ' John Williams, Obst. Trans, of London, June 3, 1885, vol. xxvii. DISEASES OF THE PELVIS. 695 anteflexed or anteverted. and bound to the bladder. The condition we here describe, as it presents itself in laparotomies, is in most cases probably a late stage of the preceding form, but in some cases there is little serous effusion from the beginning, and the exuded fibrinous lymph is soon transformed into connective tissue by a process similar to that causing dry pleurisy. This dry chronic form is particularly frequent in connection with tuberculosis, while the common acute form is ordinarily accompanied by more or less serous exudation. Pelvic peritonitis may be suppurative from the beginning, as when gonorrhea extends through the uterus and the tubes ; or a serous exudate may in the course of time, instead of being ab- sorbed, become purulent. Fortunately, this is a comparatively rare occurrence. Pus in the pelvis may be found in the tube (pyosalpinx), in the ovary (ovarian abscess), in the peritoneal cavity, or in the subperito- neal connective tissue. Often it is found in all these localities at the same time. We have described the first two in dealing with the Diseases of the Tube and the Ovary. Here we will only add that the pus-filled tube may become so distended that it occupies the wiiole pelvis, where it may adhere, so that it cannot be separated from the peritoneum. The pelvic abscess of the connective tissue will be described below. Here we have only to do with the intraperitoneal collection of j)us. On account of the preexisting wall formed by adhesions and the new irritation caused by the acrid contents, this abscess, although situate in the peritoneal cavity, is in reality, as a rule, separated from it In- a complete partition of varying tiiickness. Tills intraperitoneal al)scess may open into a hollow organ, most fre- quently the rectum, less often the vagina, and rarely the bladder. It mav rupture into the peritoneal cavity, which, fortunately, is a rare occiu'rence, and it may find its way out througli the peritoneum, the connective tissue, and the skin above or below Poupart's ligament, or burst in the gluteal region, whicii it reaches tiu'ough the great sacro- sciatic foramen. Often the abscess is only partially emj)tied through a long, narrow, and devious <'anal, surrounded by indurated tissue ; or it refills again when the outlet becomes blocked up. Such fistulous abscesses may remain indefinitely as a source of fresh attacks of peritonitis or as a drain on the patient's constitution, which makes Jier an invalid or causes death by exhaustion. In contact with the purulent collection the muscular fibers of the uterus are aj)t to undergo faltv degeneration. The inflanunatlon may follow the lymj)hatics through the lnfun(lll)ulopelvic ligament up to the diaphragtn, and cau>e dia|)hragtiiatic pleiu'ltis ; but this is of the dry varif'ty and of minor importance. 696 DISEASES OF WOMEN. Microscopical investigations* have shown that in peritonitis the en- dothelia of the peritoneum and blood-vessels, the epithelium of the ovary, the fibrous connective-tissue bundles, and the smooth muscle- fibers all break up, forming inflammatory corpuscles — i.e. small round cells — which, if they continue in connection with one another, become spindle-shaped and form new comiective tissue (adhesive peritonitis), or, if the connection between them is interru})ted, form pus-corpuscles (suppurative peritonitis). The latter is due to the influence of gono- cocci, staphylococci, or streptococci. Gonococci cause it most fre- quently. The other microbes may be introduced by unclean fingers and instruments ; since they circulate in the blood, they may be due to rupture of vessels caused by injuries, or they may be derived from a suppurating surface in a remote part of the body. False membranes consist of connective tissue with interspersed cells and blood-vessels, and not uncommonly contain miliary ab- scesses. Gonococci do not affect the lymphatics, but travel along the mucous membrane of the uterus and the tubes, while stajjhylococci are carried more rapidly by the lymphatics than in following the mucous membrane, and do not invade the veins until the lymph- vessels are choked. Streptococci are found extensively only in puerperal cases, and are transmitted in the same manner as the staphylococci.^ Etiology. — Pelvic ])eritonitis may develop in the fetus. In adults it is in most cases added to preexisting disease of some pelvic oi'gan, especially salpingitis. A serous peritonitis may accompany purulent salpingitis, for which an explanation may be sought by sup])osing the adhesions to serve as a filter, retaining the pyogenic microbes. Me- tritis may spread from the endometrium through the muscular wall out to the peritoneum, or it may first reach the connective tissue, the lymphatics, or veins of the broad ligament, and secondarily the peri- toneum. Enlargement, dis})lacement, fibroids, and cancer of the uterus are all very apt to be accompanied by peritonitis. Hematocele is limited by adhesive inflammation. Peritonitis may be due to rup- ture of a tubal pregnancy or an ovarian hematoma or abscess. Tubercular ])erit()nitis is usually propagated from the same affection in the tube. It is commonly preceded by simple })eritonitis. Peritonitis is chiefly the result of gonorrhea, trauma, childbirth, or disturbance of the menstrual flow, in all or most of which cases the real morbific cause is infection with mi(;robes. Traumatic peritonitis is often brought about by gynecological treat- ment, such as the passing of the uterine sound, application of caustics, ' Dr. M. Dixon .Jones, Medical Record, Mav 28, 1892, vol. xli. p. 599. * W. K. Pryor, Amer. Jour. ObsL, May, 1891, vol. xxv. p. 603. DISEASES OF THE PELVIS. 697 curetting, intra-uterine iujectious, teuts, stem-pessaries/ incision of the cervix, or traclielorrhaphy. Puerperal peritonitis may be gonorrheal or traumatic, in the latter case beginning as a hematoma or being due to microbes deposited on wounds by unclean fingers or instruments and similar carriers of infection. Menstrual peritonitis may be due to a malformation of the tubes or to flexion or stenosis of the uterine canal, but is in most cases brought on by exposure to cold or by coition. It is not rare in washerwomen who get wet feet, or prostitutes who bathe the genitals with cold water in order to stop the inconvenient flow. Perhaps also masturbation may cause peritonitis. Symptoms. — The symptoms of an acute attack of pelvic peritonitis are much like those of acute inflammation of the pelvic organs. The patient experiences a sudden severe pain in one side of the pelvis, which may extend over to the opposite side or down the anterior sur- face of the thigh. Slie feels faint and sometimes nauseated, and may vomit. As a rule, she has a chill, followed by rise in temperature, and a frequent small pulse. Very commonly she com])lains of rectal and vesical tenesmus. Her face has an exjn-cssion of anxiety, and she may become delirious. The abdomen is distended and tender. Metrorrhagia is of frequent occurrence. On vaginal examination is found an exquisitely tender swelling occupying Douglas's pouch or situated to one side of the uterus, and pushing tlie latter up against the symphysis, and sometimes over to the opposite side, but at the same time canting the edge forward. It is immovable. Sometimes crepitation is heard and felt, but the swelling is too tense to give fluctuation. As a rule, the fluid is absorbed, the tumor becomes smaller and disappeai's, and the uterus may regain its normal mol)iIity. In other cases induration and adhesions remain, and the uterus contimies more or less immobile. In other cases, again, recurring i'cvcr, chills, night- sweats, and a yellowish hue of the skin indicate the formation of ])us ; but all these sym])toms may be absent and, nevertheless, the exudate l)Ccome purulent. Sometimes the transformation is marked by an extension of the inflammation up into the alxlomen, l)y the oeciu'rence of persistent diarrhea due; to ulcerative (Miteritis, or by bronehoj)neu- monia with mucopuruk'nt expectoration. WiiiJe the above deseri])tioii aj)])lies to most ca'^es of acute pelvic peritonitis, there are others that pi-esent some jHvuliarities. Tims th(! temp<'ratnr(! may be normal, (»i' even sui»noi-mal, or fluctuate be- tween a high and a low mark ; which ai'c bad signs. Pain and tumor may be al>seiit in particularly dangerous eases. The tumor may fill ' I have described a case of tliis last kind in Awrr. Jour. Obat., 1S70, vol. xii. p. 7 06. 698 DISEASES OF WOMEN. the whole pelvis, extend considerably above the brim, or be as small as a pigeon's egg. It may change in position and size on account of the presence or disappearance of the accompanying edema or con- gestion. The chronic form maybe really chronic from the beginning; but oftener it is a succession of acute attacks brought on by bodily exertion, trickling of tube-contents into the peritoneal cavity, rupture of a fol- licular cyst or a distended tube. In this form the patient is often able to be up and about, and even to do some work, but she has more or less constant pain, with menstrual exacerbations. Menorrhagia or amenorrhea is common. By bimanual examination we feel on the side of the uterus the tumor described above in speaking of the pathological anatomy, or a large tumor that mounts into the abdomen simulating an ovarian cyst. Sometimes a fibrinous discharge from the uterus accompanies a serous collection in the pelvis. Prostitutes suffer often from a condition called coUca scortorum. Its symptoms are pelvic pain, fever, and purulent discharge, and it is due to slight attacks of peritonitis, and probably to painful con- tractions of the inflamed tubes. Diagnosis. — It may be impossible to differentiate pelvic peritonitis from other conditions, but in most cases the diagnosis is easy. In fresh cases the bulging tumor filling Douglas's pouch and pressing the uterus up against the symphysis is characteristic. Hematocele occupies, however, the same position, but it begins more suddenly and with greater violence, and the tumor is at first fluid, and becomes harder (p. 686), whereas peritonitis takes an opposite course. Hemor- rhage may take place into a serous pseudocyst, but the red blood- corpuscles are then chauged into pale spherical bodies, while in hema- tocele the fluid is pure blood with well-preserved or shrunken blood- corpuscles. In cellulitis the symptoms are less severe, the tumor is situated close up to the side of the uterus, and pushes it, together with the cervix, over to the other side. It may form two tumors, one on either side, connected by a bridge in front and behind the cer- vix. In peritonitis the whole vaginal vault presents one smooth, hard mass. The immobility of the uterus is less pronounced than in peritonitis. If cellulitis extends above the brim, it always follows the bone closely, while the peritonitic tumor, as a rule, is situatetl far- ther in, and allows us to insert the fingers between it and the bony pel- vis. If cellulitis involves the psoas and iliacus muscles, relief is found by flexing the corresponding limb ; in peritonitis both limbs must be drawn up to obtain the same effect. In chronic oophoritis the ovary may i)e movable, its shape is more or less recognizable, and it shows an unusual tenderness. In salpingitis the tumor is sausage-shaped, often bilateral, and follows the edge of tiie uterus. In cases of long standing the tube, may, however, be so distended as to fill the pelvis,. DISEASES OF THE PELVIS. 699 and adapt itself to the peritoneum, and then the diagnosis between this condition and a collection situated directly in the peritoneal cav- ity becomes impossible. In extra-uterine pregnancy there are signs of pregnancy, and the tumor is situated laterally. In cases of fibroid or fibrocystic tumors of the uterus this is, as a rule, movable, and the tumor moves with it. Fibroids are felt as solid nodular masses, and there is no history of acute inflammation. The uterine cavity is, as a rule, enlarged. In oop/io^'a/'^ia there is neither tumor nor inflamma- tion. An old encysted serous collection is easily mistaken for an immovable ovarian cyst, but there is the history of the acute begin- ning, and exploratory puncture shows a citrine fluid containing leuco- cytes and forming a small coagulum by exposure to the air. In the same way a peritonitic cyst is distinguished from a cyst of the broad ligament or a hydatid. In tubercular peritonitis the lungs are, as a rule, aflected. Prognosis. — When the disease is of traumatic or menstrual origin the prognosis is good, both as to life and complete recovery, but absorption may be very slow. The gonorrheal form is mucli more dangerous, and may in short time lead to death by general peritonitis or give rise to chronic peritonitis, which may end fatally through exhaustion, embolus, or tuberculization. The puerperal form is very grave. Often the patient is left with impaired health. Uterine displace- ments are a common sequel. Hematocele may develop in the adhe- sions (p. 087). Intestinal adhesions may cause constipation, alternat- ing with diarrlica, or give rise to occlusion of the bowel. Pressure on the nerves of the pelvis may cause sciatica or reflex paralysis. Steril- ity is very conmion, the ovary being covered with a false membrane tliat prevents the ovum escaping, or the tubes l)elng sealed by adhe- sions. If impregnation takes place, there is danger of the ovum being arre.ste(l in the tube; or if it reaches the uterus, the presence of a layer of old, unyielding false membrane around this organ or its fixation by adhesions in an untoward position may lead to abortion. Trcfd/iirnt. — In regard to prophylaxis the reader is referred to ■what has been said in speaking of Salpingitis (p. 5G0). "^flie ])atient nnist lie fpiietly in bed, and be kept on fluid diet (p. 240). Often a pill(»w rolled up, tied, and placed under her knees is grateful to her. In the acute stage an ice-bag or ice-water coil should be apjilied over the uterus, or, if cold is not well borne, a hot ])oulti<'e or.-tiipe(p. 195) may be substituted. Frequent hot vaginal injections should be ordei'ed, to which in infectious cases antise|)tics should be added (p. ITd). Heat may be us<'<l continually by combining the ])oultice on the abd(»men with one in the va<;;ina. or j>lacing a colpenrynter with hot water in the latter. Pain should be subdued by opiates. If it is severe, it is charitable to iK'gin with a hypodermic injection of I to 700 DISEASES OF WOMEN. 1^ of a grain of morphine. Later, the drug is given by the mouth in doses of ^ of a grain, rej)eated often enough to keep the patient com- fortable, for which purj)ose in most cases not nmch is required,^ or suppositories with | grain of pulvis opii are administered by the rec- tum every two or three hours. I prescribe in tliis as in all inflammations 5 grains of quiniue every lour houi*s, not as an antipyretic, but as an antiphlogistic. If the tem[>erature rises above 102° Fahr., antipyretics (p. 245) are indi- cated. Bacteriological researches having shown that bacilli find their way from the intestine, and change a comj)aratively harmless simple peritonitis into a dangerous septic one, it is a Avise precaution to keep the bowels open from the beginning with enemas (p. 178) or aperients, preferably sulphate of sodium (a heaping teaspoonful, repeated, if necessary, every three hours), or, if salts cause vomiting, calomel (gr. j every hour until the bowels move). When the disease after eight or ten days enters on a more subacute stage, — that is to say, Nvhen spontaneous pain and fever have ceased and the tenderness is diminished, — the patient is allowed more sub- stantial food, and Priessnitz's compress (p. 195) should replace the ice. A few days or a week later the abdomen should be painted with tincture o£ iodine, folloM'ed by a glycerin compress (p. 196). AVhen the tenderness has abated sufficiently to warrant the introduction of a speculum, the iodine is applied with greater effect to the vaginal roof every three days (p. 174), and combined with pledgets with ichthyol- glycerin (p. 182), abdominal inunction with ichthyol ointment (10 per cent.), and the internal use of iodide of potassium. By this time — about three weeks since she was taken sick — the patient will, as a rule, be well enough to get up cautiously and spend most of the day on a lounge. Still later, when she is well enough to be on her feet, galvanism with the negative pole in the uterus or vagina (p. 248). faradization with the high tension secondary current for ten minutes every day (p. 247), massage (p. 199), warm entire baths, sitz-baths (p. 196), and the constant use of a wet abdominal bandage well covered with water-proof material, are valuable means of causing absorption of exudation and inflammatory tissue. Finally, the treatment in places where they have mineral mud, so-called " moor," such as Kreuznach, Franzensbad or ]Marieni)ad in Germany, and Sandefjord in Norway, may be recommended. If serous pseudocysts remain after the acute symptoms have sub- sided, and do not yield readily to the absorbent treatment described, much time may be saved by aspirating the fluid (p. 169) from the ' In this respect, as in many others, pelvic peritonitis differs from general peri- tonitis, in which often enormous doses are not only well home, but heneficent. (See Garrigues, " The Opium Plan in Puerperal Peritonitis," N. Y. Med. Jour., Jan. 24, 1885, vol. xli. p. 98.) DISEASES OF THE PELVIS. 701 vagina; but the utmost care should be taken in disinfecting both aspirator and vagina, as otherwise the inoffensive serum may be fol- lowed by pus ; and bladder, ureters, and blood-vessels must be care- fully avoided, which limits the safe field to the posterior part of the pelvis and a moderate distance, say an inch, from the median line. In the chronic form of peritonitis, or when the acute and subacute stages have passed, the patient is allowed moderate exercise ; her diet should be nutritious and mildly stimulating (p. 240) ; but sexual intercourse should be avoided or restricted within narrow limits. To the therapeutic measures already mentioned may be added pack- ing of the vagina (p. 182), which may help to stretch adhesions and further their absorption. The internal use of resolvents (p. 242) has- tens absorption, and an abdominal belt (p. 199) often gives comfort by removing pressure from the inflamed peritoneum. PelviG Abscess.^ — If the fluid in the sac formed by the perito- neum, pelvic organs, and false membranes is purulent, it should be evacuated ; and the question arises, from what side is it best to attack the sac — from the rectum, the vagina, or the abdominal wall? To make an opening in the rectum, be it Mith trocar, aspirator, or knife, is not advisable, as the abscess inevitably becomes infected with the con- tents of the bowels. If there already is a communication with the rec- tum and it is within reach, a sound should be introduced through the opening in the rectum, bent well down against the vaginal roof, and a counter-incision made there, through which a drainage-tube with wings may be drawn, and left until the cavity is closed. It is, of course, kept clean witli daily injections of antiseptic fluid. If the rectal opening cannot be felt, the abscess cavity is entered from the vagina, as if there w<>re no communication with the int(>stine. More rarely tlie counter-opening is made in the abdominal wall. If tlio purulent collection is near tiie vaginal roof, it is best to make a larg(! ojx'uing, so as to be sure to have a free outlet and be able to insert a drainage-tube. Special foreejis have been made with which the abscess may be opened and the drainag(>-tul>e carried in.^ This method is simple and effective, and, as a rule, successful, but has the drawback that one is never sure of not woiniding a blood- vessel or the intestine. It is much safer to make a transverse in- cision beliind the cervix, separate the tissues bluntly from it, per- forate the abscess wall with my blunt ])erforator (p. 199), exj)and .lltlit'tl 111 iinj iiiijT^ \fi mi: t/i'<irV, '' Dr. I'afhe Kriiincl has (Icscrihtd aiui (K-lincilcd one in .V. }'. Mid. Rvcord Marc h 19, 18<J1'. f 702 DISEASES OF WOMEN. the instrument, enlarge the opening by means of Boldt's blunt dilator, and insert a sky-rocket drainage-tube (p. 193). If there is any bleeding, the cavity is tamponed with iodoform gauze, which, if the bleeding is not easily checked, should be steeped in diluted liquor ferri chloridi (1 : 10). The vagina is then tamponed with cotton wrung out of creolin. On the third day a double soft rubber drainage-tube with cross-bar is inserted instead of the gauze in the cavity and led out through the vulva. This allows us to inject the cavity with an antiseptic fluid without hurting the patient. The tube is removed after two or three weeks, or, if it has been fastened with silver sutures, when these cut through, which happens from ten to fourteen days after their insertion. Thereafter the tract should be washed out with iodized water, beginning with tinct. iodi oj- Oj, and graduaily increasing the strength till all secretion ceases. The injection is made with a double-current uterine tube, and if possible repeated daily. This operation has to a great extent replaced laparotomy, which in cases of suppurative pelvic peritonitis is particularly dangerous. It is especially indicated in puerperal cases, in M'hich the patient's vitality is so low that she cannot stand the shock of laparotomy or vaginal hysterectomy. If the abscess points near Poupart's ligament, a large incision is made parallel to the ligament, cutting layer by layer, and when an opening has been made a finger is introduced to the bottom, counter- pressure is made from the vagina, and, if there is not too much tissue, a counter-opening is made here and a soft rubber drainage-tube with side holes drawn through the cavity. This incision may even be used if the abscess does not point, but is at some distance from the ligament : the peritoneum is then lifted until the abscess can be entered from behind without opening the peritoneal cavity. When the pus extends upward and backward (in puerperal cel- lulitis), the most favorable point at which to cut deep is above the crest of the ilium, between the attachments of the latissimus dorsi and obliquus abdominis externus nmscles (Petifs triangle). Here a vertical incision is made, Avhich leads to the external border of the quadratus lumborum muscle. If there is reason to believe that the appendages are aflPccted, and the patient's general condition warrants the performance of a severe and tedious operation, the choice lies between laparotomy and vaginal hysterectomy. The former has the great advantage of allowing tlie operator to see, of giving him room to tie bleeding vessels, to remove the a])pendages if they are found to be the source of the sujipuration, and to empty se])arate ])us-foci wherever they may be, and of pre- venting subsequent infection. Theijjus should be aspirated and the DISEASES OF THE PELVIS 703 abscess-cavity washed out with antiseptic fluid before opening it. Even then the place where the incision is to be made should be sur- rounded by sponges or gauze pads in order to catch the contents. If the abscess unfortunately bursts, and pus enters the peritoneal cavity, it should be wiped oif with gauze pads, and a drain of iodo- form gauze be carried from the contaminated part through the wound in the abdominal wall or the one in the vaginal roof. But if the pus has spread widely among the intestinal knuckles, the cavity should be flooded with a warm solution of salt (p. 531) or thymol, or Avith Thiersch's solution (p. 218). If possible, the sac is stitched to the edges of the incision ; if not, an opening is made in the vaginal vault, drainage is established in that way, and the abscess- cavity is closed over it ; and if that too is impossible, the focus is simply opened and disinfected, and a drainage-tube or iodoform- gauze drain is brought out through the abdominal incision. If both appendages have to be removed, it is best to remove the uterus too, either by the transverse supravaginal amputation (p. 517) or Faure's method of total extirpation of the uterus (p. 568). Even when laparotomy is performed, it may be found advanta- geous to open the abscess above Poupart's ligament by lifting the peritoneum and getting in from behind, so that the abscess does not connect with the peritoneal cavity. It has been advised to o[)('n abscesses in two sittings (Hegar's method). An incision is made down to the sac without opening it ; the wound is packed with iodoform gauze, which is left in for four or five days until strong adhesions have formed all around, and then the abscess is opened. This method is ap})licable to both abdominal and vaginal incision. If the al)sccss is adherent to the anterior wall of tlie abdomen, a vertical incision is made over the most prominent ])()int. If ])os- sii)le a count(!r-o|)ening is made in the vagina, and under all circum- stances drainage is established through the openings made. Of late, laparotomy has to a great extent been rejilaced by vaginal hysterectomy and, if possible, removal of the a|)peu(lages. If tiiese cannot be removed and contain pus, they .^-hould be incised and drained thr(»ugh the vagina. This metliod pn'seuts the advantages that the |)rotecting partitioii which nature has j)laced between tlie abscess and the u])|)er part of the peritoneal cavity need, perhaps, not be broken, and that there is established free drainage through tlu» vagina. It was indeed for large, bilateral |)urulent coUec^tions in the pelvis that Pean invented his method of I>eginning with vaginal hysterectomy. On the other hand, the removal of the uterus does not always succeed, and still less that of the appendages. There is also considerable dan<;er of woundintr the intestine or bladder, and 704 DISEASES OF WO.\fEN. tlie parts are so little accessible between the hemostatic pressure- forceps fillinp: the vapna that repair becomes impossible. Often the removal of the uterus is facilitated by morcellation. (Compare Uterine Fibroid, pp. 494-502.) Other methods have been proposed in order to reach deep abscesses from the perineal or sacral region, such as vertical perineotomy, trans- verse perineotomy, and sacrotoray ; but none of these allows the operator to explore the pelvis to any great extent, and still less to remove diseased tissues or organs, as well by laparotomy or vaginal hysterectomy. To use the blunt curette in the abscess, except in cases of old standing, is hazardous, since we have seen above that the thickness of the sac varies much in different parts, and a perforation might be made unawares into the peritoneal cavity. If the abscess has opened into the bladder, a counter-opening has been made in this viscus, either by suprapubic cystotomy (Schroeder) or from the vagina (Buckmaster^), in order to establish good drain- age. But it often closes without operation by simply washing out the bladder. If the abscess opens into the ureter, it may perhaps be possible to repair the defect either by implantation of the upper end into the bladder (p. 395) or by uretero-ureteral anastomosis (p. 650). After an abscess has been emptied and well drained, the surround- ing hard masses soon disappear. Fistulous Tracts. — After spontaneous opening into the vagina the abscess heals in most cases, but if a fistula remains, and constant suppu- ration exhausts the patient, it must be dilated with the knife, dilator, or tents ; or perhaps a laparotomy may give the best access to the cavity. Spontaneous opening near Poupart's ligament or the iliac crest often leaves long sinuous fistulse that have to be dilated with laminaria or laid open with the knife, and good drainage established, sometimes by means of a counter-opening in the vagina, before recov- ery can take place. Sometimes it suffices to curette the fistulous tracts and old abscess- cavities that will not close, and inject them daily with peroxide of hydrogen, carbolized water (2 per cent.), Labarraque's solution diluted with 8 or 10 parts of water, Villate's solution^ mixed with 2 parts of water, or to use two or three times a week injections with tincture of iodine, in the beginning mixed with water, or a solution of nitrate of silver (2 per cent.). In some cases of adhesive peritonitis, laparotomy is performed with * A. H. Buckmaster, "Pelvic Abscess," Brooklyn Med. Joiir., April, 1891. 2 R. Cupri siilphat., \ ,. „. Pluinbi sulphat., )' "" ^'^-^ ' Liq. plurabi subacetat., 30.0 ; Aceti, 200.0.— M. DISEASES OF THE PELVIS. 705 the sole aim of breaking up adhesions (compare Salpingitis, p. 563). If it is possible to save the uterus and one set of appendages, it should be done (pp. 514 and 569) ; but if the tubes and the uterus are the seat of suj)pu ration, it is best to remove them, as the source of the suppurative peritonitis. B. Pelvic Cellulitis. Pelvic cellulitis is the inflammation of the connective tissue in the pelvis above the pelvic diaphragm. We have seen in the anatomi- cal part (p. 95) that there is a large amount of such tissue in this locality, and especially around and in the broad ligaments, and that it is in direct connection with the same kind of tissue outside of the abdominal peritoneum and under the skin. Some modern gynecolo- gists would have us believe that inflammation is rare in this tissue, and that, when it does occur, it rarely runs into suppuration. It is an unfortunate, but common, quality of the human mind to be en- grossed by one idea to the exclusion of others. When a new discovery is made we are apt to be dazzled by it to such a degree that we over- look other equally well-established facts. There was a time when every pelvic inflanmiation was looked upon as cellulitis ; then there came a reaction and it was all peritonitis ; and of late many exclusively lay stress on salpingitis. As a matter of fact, connective tissue in the pelvis, just as anywhere else in the body, is })rone to become inflamed ; but, as a rule, we have only clinical evidence of its existence. Since the patients usually recover, we have only few auto})sies to fortify our argument with. Yet we have some performed on women in which the inflammation was strictly confined to the connective tissue, without implicating perito- neum, tube, or ovary ; and there is the still more convincing case of a man who fell asleep on a Met bridge, and in whose pelvic connective tissue a large al)sccss formed, while the })eritoncum was entirely free.* In this case certainly no ])uerj)eral influence could be invoked, nor could the cellulitis l)e attributed to uterus, tubes, or ovaries. Some gynecologists exj)ress themselves as if the disease did not concern tliem when it is connected witii childbirth and abortion ; but, even if they do not practice obstetrics, they are very likely to be called in when an ojx'ration has to be performed, and science is one inde- pendently of the limits witiiin wiiich the j)hysi('ian may find it con- venient to confine his work. Jiut, even indej)endently of puerj)eral influences, celhilitis exists, and if we do not see it in laparotomies as often as we find ])eritonitis, it is for the simple reason that few lapa- rotomies are j)crf()rmed when the inflammation is limited to the pelvic connective tissue. ' T. 11. Burclianl, "Pelvic AItw-csr in tlie Male," piipcr read before the X. Y. Academy of Medicine, April 15, 1880. * 45 706 DISEASES OF WOMEN. Cellulitis not only exists, but it is a rather common occurrence, and useti especially to be so before antiseptic midwifery and sur- gery were so nmch practised as they are now-a-days. Certain localities are more liable to be affected than others, because they con- tain a larger amount of connective tissue, and because they are more exposed to injury — viz. the broad ligaments, the surroundings of the lower uterine segment and the fornix of the vagina, the sacro-uterine ligaments, and the space between the cervix and the bladder. Cellulitis may be acute or chronic. Acute cellulitis may arise by propagation of the inflammation from a tear or ulcers in the cervix or from corporeal endometritis, the inflam- mation spreading through the intermuscular connective tissue. It may also begin directly in a tear extending into the parametrium, or it may begin anywhere in the depth of bruised tissue. In most cases it is combined with pelvic peritonitis, lymphangitis, or phlebitis. That peritonitis and cellulitis go together, whether one or the other is the primary affection, is easy to understand, since the ijeritoneuni and the connective tissue are not only in contact, but the peritoneum is only a modification of connective tissue. When cellulitis is combined with lymphangitis, the latter is the pri- mary lesion, the lymph-vessels becoming inflamed in the uterus or in the tear of the cervix, and carrying the infection through and into the connective tissue. Phlebitis may be primary, extending from inflamed uterine sinuses, or secondary, beginning as periphlebitis by contact Avith inflamed connective tissue, and gradually gaining the deeper coats of the vein. Cellulitis is seldom bilateral. We may distinguish between a simple traumatic form and a sej^tic form. Both are due to infection with bacteria, but in the first simple bacteria of putrefaction are at work ; in the second we have to deal with specific pathogenic bacteria. Either of these forms may, again, be 2'>uerperal or non-puerperal. The traumatic extends in the loose connective tissue, following the interstices between sheets of hard connective tissue ; the septic respects no boundaries. As in other inflammations, we may distinguish different stages, one of infiltration, followed by one of resolution, suppuration, or organ- ization, Diu'ing the stage of infiltration the connective tissue is swollen by exudation of serum and formation of small round cells, which change the tissue into a gelatinous yellow mass. In most cases the serous fluid and the form-elements disappear again in the course of two or three weeks. In others pus is formed, and of all perimetric inflammations cellulitis is the one which most frequently ends in suppuration. Often the melting into pus takes place at several distinct points, and DISEASES OF THE PELVIS. 707 it is only in the course of time that these separate foci unite into one large abscess-cavity. As to tlie routes followed by the pus and the point where the abscess breaks, the reader is referred to what has been said above in speaking of pelvic abscess in general (p. 695). Here we shall only add that while a puerperal abscess commonly finds an outlet through the skin ; — breaking above Poupart's ligament or, more rarely, below the same; following the vagina down to the labium majus and the anus; going through the obturator foramen or the greater sacro-sciatic foramen ; or following the round ligament through the inguinal canal ; — the non-puerperal very rarely perforates the skin, and is usually discharged into one of the hollow organs in the pelvis. The abscess in the connective tissue rarely ruptures into the peri- toneal cavity, fatal i)eritonitis being, as a rule, due to simple extension of the inflammation to the peritoneum. C(!llulitis often leads to uterine displacement, cicatricial retraction of the sacro-uterine ligaments causing anteflexion (p. 458), and that of the broad ligament lateroversion (p. 478). If the inflammation ends in organization, pus may still form in the indurated tissue after a long time. Chronic Cellulitis. — Chronic cellulitis is found as a remnant of the acute form in the shape of cicatrices, indurated bands, discharging abscesses, and fistulous tracts. It may also be an originally chronic cirrhosis (atrophic chronic cellulitis), which will be described later. Etiologi/. — Acute cellulitis is not found in childhood, and is rare after the menopause. It is confined to the age of sexual maturity, and es]>ecially to the jnierperal state. Puerperal cellulitis may be due to a tear in the cervix in an other- wise normal labor ; but is especially caused by obstetric o])erations, such as forcal dilatation of the cervix or the extraction of the child with forceps through a narrow ])elvis. It may join inflammation of the uterus, tubes, and ovaries. Sometimes a hematoma — puerj)eral or non-puerperal — is first formal, which later supj)urates. Non-puerj>eral cellulitis is due to the use of tents, over-distention and other operations on the cervix, enucleation of tumors, or the presence of a non-pueri)eral hematoma. But, finally, all these cases are due to infection, and the dill'erence in their course depends on the difl'ercnt kinds of microbes at work, es})ecially the difterence between common bacteria of putrelaction and specilically pathogenic micro- cocci. Cellulitis may also be brought on by exposure to cold. Syinptoiiui. — The sym[)toins an; nuich like those of peritonitis, but with certain differences. The i)atient may have; a chill; there is a rise in temperature; her [)ulse l)e('omes fre<juent ; her tongue is furred ; she feels weak ; she has no a|)petite ; she has pain in the lower part of the alxlomen, and, perhaps, vesical or rectal tenesiinis ; but the 708 DISEASES OF WOMEN. pain is not so sudden nor so severe as in peritonitis ; there is less tendency to vomiting, and no distention of the abdomen. On vaginal examination we iind heat, swelling, and considerable tenderness. If the broad ligalnent is the seat of the disease, we feel a tumor varying in size between a walnut and an apple. If sufficiently large, it pushes the uterus over to the opposite side. If the inflammation is bilateral, the uterus is lifted up, and often the two lateral tumors may be felt connected by a bridge in front and behind the cervix. If the con- nective tissue around the sacro-uterine ligaments is affected, we feel the semilunar fold forming the upper limit of Douglas's pouch swollen on one or both sides. Occasionally the swelling may be limited to the connective tissue behind or in front of the cervix {iwsterior or anterior cellulitis). If the inflammation extends to the iliac fossa, the corresponding leg is drawn up. Transition to pus is marked by the swelling becoming soft, but hardly distinctly fluctuating. Induration of the tissue may last for many months. Often irrita- bility of the bladder continues after the fever and swelling have sub- sided — a symptom which is referable to shortening of the sacro-ute- rine ligaments, which pull on the cervix and indirectly on the base of the bladder, which is bound to it with a thin layer of connective tissue. As to other sequels, we may find amenorrhea, menorrhagia, or dysmenorrhea. Diagnosis. — Enough has been said under the Symptomatology and in speaking of pelvic peritonitis (p. 698) about the difference be- tween cellulitis and the latter disease. Hematoma begins suddenly without fever and with great pain. An inflamed ovarian tumor may be very hard to differentiate except by the history and later course of the disease. A common ovarian tumor is movable. A uterine fibroid forms one mass with the uterus and moves with it, whereas in cellu- litis it is possible to feel a groove between that organ and the swelling in the broad ligament, and the uterus is more or less immovable. Retrojja'itoneal sarcoma is a chronic disease, in which the constitution soon suffers. Prognosis. — The prognosis of cellulitis is less grave than that of peritonitis. It may, however, become fatal in a short time through septicemia or develop into the more dangerous peritonitis. As a rule, the prognosis is good as to life, but very uncertain as to time and complete recovery. Treatment. — All that lias been said above about the treatment of peritonitis (p. 699, et seq.) applies to cellulitis, whether an abscess is formed or not. I shall, therefore, limit myself to a few additional re- marks bearing especially upon cellulitis. Prophylaxis consists in avoidance of refrigeration and in antise])tic midwifery and surgery. Slowly dilating tents should, as far as possi- DISEASES OF THE PELVIS 709 ble, be discarded, and be replaced by rapid dilatation with steel dilators. Instead of the hot douche, some recommend a continuous current of ice-water, beginning at a pleasantly warm temperature and dimin- ishing the heat gradually. This injection can easily be administered through Frost's vaginal syringe (Fig. 363), which plugs the vagina and has an efferent tube leading to a vessel under the bed. If pus begins to form, the maturation of the abscess should be fur- thered by the use of warm abdominal poultices and warm vaginal injections. When pus begins to form in several foci, it is best to give them time to unite before opening the abscess. If an abscess forms between the uterus and the bladder, it must be opened very cautiously by anterior transverse colpotomy, enter- ing the space between the bladder, the vagina, and the cervix with Fig. 363. Frost's Vaginal Syringe. the finger and blunt instruments, enlarging the opening cautiously with my blunt expanding dilator, and draining with a rubber tube or iodoform gauze. An abscess in the broad ligament may be reached l)y ])artial exci- sion of the uterus.' First tlic cervix is removed, and tlien so much of tlie body cut away that the finger can be introduced into the abscess-cavity. Hemorrhage is controlled by liemostatic fi)rceps, wliicli arc left in j)la('e for forty-eight hours. This method would only be availubh' in women with a hirge vagina ; and tliis muti- lating oj)eration may pr<)bal)ly l)e avoided l)y ap])roaehing tlie abscess either bv posterior or anterior colj)otoniy, oj)ening it, and enhirging the opening as described al)ove ()>. 701 ). Some? go <'ven so far as to perform total vaginal hysterectomy in order to reaeii a purulent collection in the pelvis, whether situated in the conne(;tive tissue or elsewhere.^ It was doubtless a great progress ' Landau, Cmlrnlhlnll fiir G)/iiii/,»l(i'ilr, 1802, No. 3-5, vol. xvi. j). CiSO. '' lY-an, Hulhtin (k V Artulrmir ,1,- Mdlrrim-, No. 27, 1890 ; Sok<'11<1 " I>e I'JIy.sti'rec- toniie vaginale dans le Traitt'inent dts Supjuiration.s pelviennes," Revue dc C/iiniryie, 1891, No. 4, 710 DISEASES OF WOMEN. when P6an in 1890 iutroduocd vagiual hysterectomy for large puru- lent collections in the pelvis, and invented a new technique for its performance. This was the starting-point of the new vaginal method as opposed to the abdominal section, which had reigned since 1872. But, as in the beginning, many appendages were extirpated which might have been cured or were not diseased ; doubtless many uteri now share their fote, and the vagiual method is probably sometimes more used for display of the surgeon's dexterity than because the ope- ration is done better and more safely by that method than by lapa- rotomy. (Compare Pelvic Abscess, p. 703.) In regard to the technique the reader is referred to the description of vaginal hysterectomy by the clamp method (p. 510). In a case of pelvic abscess that had opened into the bladder recov- ery was obtained by making an artificial vesico-vaginal fistula, dilat- ing the opening between the bladder and the abscess, thrusting a pair of scissors in front of the cervix into the abscess, dilating the opening thus made, and fastening a drainage-tube there.^ Chronic Atrophic Cellulitis? — It consists in a cirrhotic contracti<)n and hardening of the pelvic connective tissue, like that taking place in the kidneys, liver, spleen, lungs, and other organs. It appears in a circumscribed and diffuse form. The circumscribed is due to ulcers in the bladder and the rectum, laceration of the cervix, or chronic metritis. The induration is situated on a level with the so-called superior sphincter. On the anterior wall of the vagina, correspond- ing to the base of the bladder, is found a stellate cicatrice, from Mhich the induration can be followed more or less far into the surrounding parts. This condition is combined with congestion of the hemor- rhoidal veins. The diifuse form starts from the base of the broad ligament, and may extend through the whole pelvis. The arteries are diminished in size; the veins are either narrowed or dilated, and contain often thrombi or ])hleboliths. It leads to venous congestion and varicosities, atrophy and sclerosis of the uterus, and synechise between the walls of the cervix. The vagina is shortened, and often funnel-shaped. The cervical ganglion (p. 65) is covered and inter- spersed wnth cicatricial tissue. The causes of the diffuse form are the same as those of the circum- scribed or too great or too frequent sexual excitement, especially mas- turbation, and losses through hemorrhage and Icucorrhea. Chlorotic women with hypoplasia of the genitals and the circulatory system are particularly predisposed to it. Symptoms. — Patients aifected with chronic atrophic cellulitis have a decided propensity to masturbation^ with indifference, or even aver- ^ A. H. Buckmaster, Brooklyn Med. Jour., April, 1891. ' This disease has heen described by Wilhelm A. Freund in Gijnak. Klinik, vol. i. pp. 239-326, hftrassburg, 1885. DISEASES OF THE PELVIS. 711 sion, for coition. They suffer often from erotic dreams, with emis- sions of mucus. They complain of pain in the iliac fossa, dyschezia, dysuria, dysmenorrhea, often intermenstrual pain (p. 437), and always present hysterical symptoms, among others copiopia hysterica (p. 265). Prognosis. — The circumscribed form may be cured when the cause is removed, and especially if pregnancy supervenes. The diffuse is incurable, but may remain stationary for long periods. Treatment. — The causes must be removed, the vagina treated with iodine glycerin or ichthyol glycerin and packing, and cicatrices cut out or incised and stretched (p. 374). The many reflex neuroses are treated as hysteria, especially with nitrate of bisnuith, nitrate of silver, acetate of zinc, ammonia, castoreum, and valerian. During the hysterical attack nothing should be done, as any interference only serves to make the condition woVse.^ C. Pelvic Phlebitis. Pelvic phlebitis is a rare disease. It is primary in puerperal cases, the inflammation starting in the sinuses of the uterus. In this variety the inflammation begins in the internal coat, and soon a thrombus forms in the lumen. The inflammation spreads outward, and may implicate the connective tissue. In non-puerperal cases it is exceedingly rare, and begins as peri- phlebitis, an afl'ection following secondarily after acute cellulitis. Congestion of the pelvic veins is very common, and the presence of phleboliths in the veins at the base of the broad ligament is not a rare occurrence. This congestion, which nuist not be confounded with pldcbitis, is often much relieved by lifting tlie uterus with a pessary, and thereby giving a straighter course to the veins. Pelvic phlcliitis blends always with cellulitis, and clinically they cannot be distinguished. D. Pelvic Li/mphancjitis and LympliadenHis. In the section on Anatomy (p. fil), we have seen that the uterus is exceedingly rich in lymph-vessels, uniting in tnuiks which traverse the broad ligaments and lead to the different glands in the pelvis. The lym])hatics from the upper two-thirds of the vagina go the same way, while those from the vulva and the lower third of the vagina go to the sup(TficiaI inguinal glands, that communicate with tlu; deep inguinal glands, from which other vessels go to the external iliac glands. Tlios<' from the tube and the ovary traverse the broad liga- ment, and go through the int'uudibulopelvic ligament to the lumlxir glands. ' 111 thisroniu'ction it is<]uito ititon'stin},' that ]"rcun<l states tliat in Strasshiir;,' tliey do not see the attacks (ieseril)e(l liy Chareot in I'aris — an experience wiiich is shared by many others in otiier j)hici's. 712 DISEASES OF WOMEN. The inflammatiou may extend from any part of the genital tract into the broad liorament and the peritoneum, causing lymphangitis, lymphadenitis, cclhilitis, or peritonitis. The lymphatic vessels jilay a very important part in the propaga- tion of infection in the puerperal state,^ and the inflammation follow- ing is then acute. In non-puerperal cases lymphangitis and lymphadenitis also exist, but seem to be rare, or so blended with other pelvic inflammations that they seldom can be discovered. ]\lany autliors do not mention the affection at all ; others have little to say about it or are doubtful as to its existence. In an extended gynecological practice I have met with only one or two cases. But tlie disease having been described by such excellent observers as Courty, Championniere, Munde, A. Martin, and others, each of whom claims to have seen, if not many, at least a certain number of cases, I shall here give a resume of their descriptions. The non-puerperal form is either acute or chronic, more frequently the latter. Lymphadenitis is characterized by the occurrence of small, rounded, irregular, uneven tumors, varying in size from a pea to a small hazelnut, and situated to the sides of the isthmus of the uterus, more frequently on the right, or on the posterior surface of the uterus. They are loosely connected with the latter and the vagina. Most authors claim only to have felt from one to three such tumors, but Mund^ has found at least twenty^ on the posterior surface of the uterus, and ]\Iartin speaks of glands in the broad ligaments forming rows like strings of pearls of moderate size.^ Now, there is this objection to the theory of looking upon these tumors as glands, that only those glands which I have mentioned in the anatomical part have been found in the pelvis by anatomists — namely, the obturator gland, the inguinal glands, the iliac glands, and the sacral glands. On the posterior surface of the uterus there are none ; but, on the other hand, there are large plexuses of lymphatic vessels ; and those small tumors felt clinically above the posterior vault of the vagina are probably clusters of swollen lymph-vessels or pouch-like dilatations of such vessels, just as we find them in puer- peral cases, in Mhich they may reach the size of a cherry. The same explanation holds good for the rows of swellings felt in the broad ligament. A third possibility is that the small tumors may be due to local- ized perilymphatic inflammation. A. Martin thinks that cellulitis often begins as lymphadenitis, the * See Garrigues, "Puerperal Infection," Hirst's Amer. System of Obstetrics, vol. ii. pp 290-378. *P. F. Mund^, Amer. Jour. Obst., 1883, vol. xvi. p. 1018. ' A. Martin, Frauenkrankheiten, p. 323. DISEASES OF THE PELVIS 713 gland suppurating and pouring its contents into the connective tissue of the broad ligament. Even without such suppuration and rupture it is very likely that cellulitis often starts from })erilymphangitis. Etiology. — The inflammation of the lymphatics is caused by endo- metritis — either catarrhal or non-specific purulent or gonorrheal. Lymphadenitis may also be due to syphilis or scrofula, when it is apt to be combined with adenitis in other parts of the body. Si/mptoms. — The patient complains of a pain deep in the pelvis, rather to one side, especially the right, extending to the pubes and the obturator foramen or downward and backward to the coccyx, and of a tenderness rendering coition painful. There is no rise in tem- perature. The parametrium is swollen and tender, but without effusion. The uterus is movable, but its movement causes pain. It is enlarged, tender, and often retroflexed. The ovaries are also swollen and tender. Behind and to the sides of the uterus are felt the above-described small tumors, which are very tender and some- what movable, or a bundle of tender, movable cords Avhich imi)art a feeling like a bunch of angle- worms.^ Diagnosis. — The tumors are much smaller and situated lower down than the ovary, not so movable, and when pressed do not cause the sickening pain elicited by pressure on the sexual gland. Their own mobility and the mobility of the womb distinguish them from cellulitis. The movable, worm-like cords are pathognomonic of lymphangitis. Treatment. — When endometritis is the cause, it should be treated according to the rules laid down for that purj)(>sc (pp. 432 and 489). Iodine (p. 174) and ichthyol glycerin (p. 182) should be used in the vagina. Packing of the vagina (p. 182) gives much relief and makes the swelling disaj)pear. Iodoform su])])ositories (p. 243) are useful both as anodynes and as resolvents. It is recommended to use inunc- tions of Ung. hydrargyri (20 parts) and Ext. belladonnas (1 part) on the hypogastric region. Galvanism has also ])rove(l bonefi'-ial. In extreme cases it may be justifiable to try to favor involution of the hyper])lastic uterus by amputation of the cervix (p. 438), If the patient is affecte<l with scrofula or syphilis, the usual remedies for those diseases should be combined with the local treatment. ' TliP preat tendfrness of the tumors, even in clironic ra«es, speaks also ajjainst their Injintr kI-'ukIs. for clironically inflamed lymph-glands, wliidi are so common in Bcrofula and syphilis, are not sensitive to touch. 714 DISEASES OF WOMEN. CHAPTER VIII. Sarcom.a and Carcinoma of the Pelvic Peritoneum and Connective Tissue. Cancer of the pelvis is usually only part of a similar affection spread over a larger territory or a direct propagation by continuity from neighboring organs. Thus, carcinoma of the broad ligament appears in connection with the same affection in other parts of the peritoneum, or begins as carcinoma of the uterus or the ovary. But both sarcoma and carcinoma may start as a primary disease in Douglas's pouch, and carcinoma may begin in the lymphatic glands. Sarcoma may form a large tumor behind the uterus, pushing this organ forward. Medullary carcinoma often appears as a relapse in the cicatrix after removal of the carcinomatous uterus. The malignant nature of these affections is proved by the cachexia which rapidly follows their advent. It is rarely possible to do any- thing of therapeutical value for them, except in the cases of relapse after hysterectomy. A patient who has had her uterus extirpated should be examined every few months for many years, and as soon as a local relapse appears the diseased tissue should be cut away and the wound cauterized.' In cases of malignant abdominal tumors that cannot be operated on, a cure may perhaps be effected by injection of the " Coley mixt- ure," containing bacillus erysipelatis and bacillus prodigiosus. The dose is from TTtss to TTLxx, beginning with the smallest and increas- ing till the temperature reaches 103°-104° F. The injection is, if possible, made into the tumor itself, and repeated every two or three days.' The remedy has been remarkably successful in some cases of sarcoma, but less so in carcinoma. ^ Dr. ]M. D. Jones has reported a case in which a carcinomatous tumor of the size of an orange in tlie pelvic floor was combined with a similar afiection of the ovaries. .She removed all tlie diseased tissue, and made a microscopical examination that ia of great interest, because it proves that the so-called inflammatory infiltration that surrounds a carcinoma to a distance of a quarter to half an inch is in reality a pre- cursory stage of carcinomatous infiltration, the inflammatory corpuscles shaping them- selves into tlie epithelial cells characteristic of carcinoma, and that the disease spreads by such cancer-cells being transmitted into the lymphatics and causing thrombosis of, and carcinomatous infection around, them {Medical Beconl, March 11, 1893, vol. xliii. p. 292). 2 W. B. Colev of New York, Amer. Jour. Med. Sci., May, 1893, July, 1894, Sept., 1896; Med. Record, Mav 18, 1895, p. 609, August 27, 1898. DISEASES OF THE PELVIS. 715 CHAPTER IX. Hydatids (Echixococci) of the Pelvis. Hydatids are so rare that few physicians have had opportunity to see a ease,^ but of the entire number reported 4 per cent, were situated in the pelvis ; and the disease is by far more common in women than in men.^ Pelvic hydatids are most common in the connective tissue of the posterior part of the pelvis near the rectum, but are also found in the uterus, the ovaries, the broad ligaments, the anterior part of the pel- vis, and anywhere in the bones. As a rule, the animal consists of a mother-cyst with endogenous or exogenous daughter-cysts. The mul- tilocular, or alveolar, Ibrm has uever been found in the pelvis. The echinococcus may enter the pelvis as a germ or reach it by extension from another part of the abdomen. Beginning in the pel- vis, the cyst may rise above the superior strait or follow the connect- ive tissue of the pelvis, press down on the perineum, grow out through the great sacro-sciatic foramen or the crural canal, and extend up on the anterior wall of the abdomen. In consequence of pressure from neighboring organs the animal may die, the fluid become turbid, puru- lent, or sanious, and the vesicles be broken up into shreds. Rupture may take place into the bladder, or exceptionally into the uterus or the vagina, but never into the peritoneal cavity — the peritoneum, on the contrary, always becoming thickened. Such rupture may lead to a cure. Etiology. — The disease is due to the entrance into the body of the eggs of the Tccnia echinococcus of the dog. As a rule, the entrance takes place through the moutli, but some women allowing their geni- tals to be licked by dogs for libidinous purposes, it is not impossible that the germs might be brought directly into the genital tract instead of passing througli the alimentary canal. The disease is endemic in certain parts of the world, such as Australia, Iceland, Mecklenburg, and Silesia. Syiaptorns. — The disease may exist for years without impairing the ' Personally, I have only seen one case, and that was in the liver {PrncecilingK of the Meilicdl Sorirty r,f Kinf/i', IJnioklyn, \. Y., IST'], vol. i. No."), p. 1'2I>). In the ahove description I chiefly follow \V. .\. I'"reinid, who, livinjif for many years in an echinococcus (iistrict, has had the rare opi)ortMnity of treating,' eif^hteen cases of hydatid disease in the true and false pelvis, and who has descrihed thetn in his Klinik (lir (rj/Kiikoln'/ir, vol. i. i)p. 29!*-!i'2(). Four of these he lias previously descrihed, conjointiv with .J. K. Chadwick of IJoston (Aiiht. .lour. 01)4., Feb., 1875, vol. vii. pp. 668-079)". * The Icelandic physician .Ion Finsen personally treated "2 15 cases of echinococcus disease. Of these. 17'J, or more than 70 per cent., were in the female sex ( (^i/rshri/l for Jy(rr/rr, '-'A series, 'A<\ vol. Nos. ')-8, ( 'opeidia^cn, 1S(J7). A French translation, made hv mvself from the Danish original, is found in Archives gcnemks de Medecine, Jan. and Feb., 1809, vol. i. pp. 23-40 and 191-210). 716 DISEASES OF WOMEN. general health or even causing much local trouble. Attention is first called to it when it causes dyschezia, dysuria, or dystocia, and often it gives rise to leucorrhea or menorrhagia. Later the nutrition suf- fei-s, the patient loses flesh, and she may become feverish, either when suppuration sets in or when the constitution becomes undermined. In consequence of pressure her feet may swell, her legs become paralyzed, she may have sciatic neuralgia or hydronephrosis, and even intestinal obstruction may develop. Death is often due to the presence of an echinococcus cyst in another organ. Diagnosis. — The disease being nearly exclusively limited to certain regions, geographical considerations may give a hint as to its exist- ence. Early in its course the presence of one or more round, remark- ably smooth, tensely elastic tumors in the connective tissue of the posterior part of the pelvis, with a thin homogeneous wall, little movable, insensitive, unconnected with the uterus or the ovaries, and not causing any local or general disturbance, makes it very likely that one has to deal with one or more echinococcus cysts in the con- nective tissue. The last point is the basis of the diiferential diagnosis from intraligamentous ovarian cysts, which very early become the source of such disturbances. The cervix is also very characteristic in hyda- tids, being situated in a depression surrounded by an elastic mass like an air-cushion. The fluid contained in the cyst is colorless, opalescent, or yellow ; clear or turbid. It does not contain albumin or only traces of it, but succinic acid, leucin, grape-sugar, iuosite, and sometimes urea and uric acid. A single booklet from the scolices (young tape-worms) or the smallest piece of cuticula (the tunica propria of the sac) which shows parallel structureless layers arranged with the utmost regularity, and which is not affected by acetic acid, is pathognomonic of a hydatid.^ If exploratory puncture is resorted to, it must, however, be made with the strictest antiseptic precautions. A vesicular mole always forms one continuous body, and has cha- racteristic appendages, while the echinococcus often is multiple, and has a smooth surface. Fibroma is harder and nodular. The hydatidic thrill cannot be utilized for the diagnosis, as it cannot be felt in pelvic hydatids. Treatment. — If the tumor is confined to the pelvis, and does not cause much discomfort, it is better to leave it alone. But if it is necessary to interfere, it is best to make a large incision in the vagina. If there are numerous tumors, the internal use of ])otassium iodide and tincture of kamala (3J-§ss) has been recommended. Electrol- ysis may, perhaps, kill the animal and cause absorption. A submu- cous uterine hydatid may be treated with ergot in the hope of its becoming pedunculated like a fibroid polypus. If the tumor rises ^ Garrigues, Diagnosis of Ovarian Cysts, p. 74. DISEASES OF THE PELVIS. 717 into the abdominal cavity, laparotomy should be performed, the tumor enucleated, and the cyst-wall of connective tissue formed around the animal, the so-called ectocyst, treated as after enucleation of a fibroid (p. 507). Often it is not possible to remove the whole mother-cyst, and then the edges of the opening made in the cyst should be stitched to those of the abdominal incision and packed with iodoform gauze. After spontaneous rupture of an echinococcus cyst it is necessary to dilate the opening or make a counter-opening. APPENDIX. I. STERILITY. Just as I found it proi)er to begin the description of the diseases of -women by special chapters on the two symptoms hemorrhage and leucorrhea, I deem it advisable for practical purposes to finish with one on sterility, since it is a symptom that often impels the patient to seek medical advice, depends upon a great variety of conditions, and calls for special treatment, part of which has not been described in the foregoing pages. "We have seen in the section on Physiology (p. 123) that fecunda- tion consists in the union of the male and the female generative elements ; but many obstacles may prevent such union, or, if it takes place, prevent the development that results in the formation of a fetus. The premature expulsion of the fetus by abortion or miscarriage, which also leads to childlessness, belongs to the domain of obstetrics. By sterility, barrenness, or infecundity we understand the lack of capacity for conception or impregnation. One marriage out of every eight is childless. It is commonly believed that the fault is always or nearly always to be found in the wife, and with some people it has been deemed a sufficient cause for repudiation ; but modern investiga- tion has shown that the husband is at fault in about one case out of every six.^ Sterility in the Hale. — Infecundity in man may be due to imjwtence, or inability to perform the sexual act ; to asjiermatism, absence of ejaculation ; or to azoospermia (also called azoospermatism or azob- spermism), the condition in which the ejaculated semen does not con- tain any spermatozoids, and, therefore, has no fertilizing power. It even seems that the man may ])roduce healthy semen in liis testicles, but that by admixture with abnormal secretions during the passage through the vas deferens, the canalis ejaculatorius, and the urethra a change takes place, in consequence of which the spermatozoids soon die. The chief cause of sterility in the male is latent gonorrhea. A man may have been free from gonorrheal discharge for years, and ^ Samuel AV. Gross, Impotence, Sterility, and Allied Disorders in the Male Sexual Organs, Philadelphia, 1881, p. 88. 718 APPENDIX. 719 still an olive-pointed bougie may discover wide strictures in the mem- branous part of the urethra, and bring to light a drop of muco-pus, while at the same time spermatozoids are absent, a condition which is supposed to be due to the action of micrococci/ Sterility in the Female. — The female genital tract being so much longer than that of the male, and subject to such numerous diseases, it is quite natural that the cause of barren marriages is found so much more frequently in woman than in man. It should be borne in mind that fecundity in Avomen is limited to a certain period of their lives. Before puberty and after the climac- teric sterility is normal. Sterility may be primary or secondary. It is primary Avhen a woman, in spite of frequent intercourse, never conceives ; it is sec- ondary if it appears after she has had one or a few children. The sexual element (the ovum) may be absent or it may be pre- vented from contact witli the male element, the spermatozoid, by incapacity for copulation, which, again, may be mechanical or nerv- ous; by incapacity for conception, which may be due to local tis- sue-changes or constitutional disturbances; or by incapacity for ges- tation. 1. Absence of Ova. — In chronic oophoritis the ovisacs and ova are often diseased and disappear (p. 594). By the development of cysts and solid tumors of the ovaries the ovisacs may disap})ear, but the sterility so common in these cases is often due to other causes (p. 623). 2. Incapacity for Copulation. — Incapacity for copulation may be mechanical or nervous. (a) Mechanical incapacity may either be ((b-solutr, as in cases of the absence of the vulva (p. 273), coalescence of labia (}). 27G), or atre- sia of the hymen (p. 345) or vagina (p. 347) ; or it may only be relative, opposing a more or less important obstacle to the perfect union of the sexes, such as solid or cystic ttimors of the vulva (pp. 294-30G), kraurosis (p. 307), or cysts, fil)r()i(ls, mucous polypi, or carcinoma of tlie vagina (pp. 378, 379, 381 ). A tear of the peri- neum, allowing the semen to How out, may also be a cause of steril- ity, but is of c<)m})arativcly small importance. {h) Xeri-ous incapacity is connected with hyj)eresthesia of the vulva (p. 294), painful urethral caruncle (p. 300), and, in its worst Ibrm, witii vaginisnuis ([). 375). 3. Incapacity for conception may either be local or constitutional, (a) Local incapacity may, again, constitute an absolutely insur- ' E. Noet^ijeratli was the first to call attciifion to latent ponorrliea in both sexes, and its iiitlnenei' on fertility ( Tniiii<. Ainrr. (lyn. Soc, 187'), vol. i. p. 2GS, ct .sw/.). ' These retrojrrade l^rlK^'sses hi;ve In-en earefnlly studied and delineated by Mary Dixon Jones {MaL Jtironl, Sept. I'J, 1891, vol. xl. p. 324; and Amcr. Jour, ('bst., 1897, vol. xxxvi. pp. 17o-200j. 720 APPENDIX. mountable obstacle to conception, as in cases of absence of the uterus (p. 406), a rudimentary uterus (p. 407), atresia of the genital canal (pp. 345, 347, 410, 440), or only a more or less serious hindrance. Vaginal catarrh (p. 364) may cause sterility through the hyperacidity of the discharge, which kills the spermatozoids. Women with urinary fistulae rarely conceive, partly on account of mutual disinclination to copulation, partly in consequence of concomitant diseased conditions. Most of the maliformations and diseases of the uterus, tubes, ovaries, and pelvis are accompanied by or have a tendency to produce sterility, such as the fetal, infantile, or pubescent uterus (pp. 411, 412), congen- ital or acquired displacements of the uterus (pp. 413, 453-483), elongation and hypertrophy of the cervix (pp. 400, 431), stenosis of the cervical canal (pp. 413, 441), superinvolution of the uterus (p. 451), chronic endometritis (p. 427), or a polypus obstructing the cervix or the tube (p. 492). Women with sessile fibroids are, as a rule, also sterile, and their barrenness is probably due more to the accompanying catarrh than to the mechanical obstruction. In car- cinoma of the cervix (p. 535) infecundity may be due to the consti- tutional disturbance as well as to mechanical obstacles. In regard to the Fallopian tubes congenital contortions (p. 553) or acquired displacement (p. 578) may oppose an impediment to the free movement of the ovum or the spermatozoids. They may be imper- vious (553), or their inflammation (p. 557) or neoplasms (p. 578) may prevent conception. The surface of the ovaries may be so covered with inflammatory products that the ovum cannot escape (p. 594). The presence of hydatids in the pelvis (p. 715) or a mole in the uterus, uterine hemorrhage, or leucorrhea from whatever cause, may render the woman sterile. (6) Constitutional Incapacity. — Anemic women are less likely to conceive than healthy women. Great obesity is quite frequently accompanied by barrenness. Tuberculosis, syphilis, and cancer, all diminish fecundity. The same applies to masturbation (p. 320) and to too frequent or violent coition, as in prostitutes. It is not unlikely that in the last-named condition impregnation often takes place, but that the ovum is expelled at so early a date that not even menstruation is interrupted. Bisulphide of carbon seems to exercise a highly deleterious influence on procreation in both sexes among those whose calling exposes them to its influence. It is used much in the arts as a solvent for vegetable oil and rubber. In the male it lessens the desire and the power for sexual intercourse. In females conception is rare, and, when it takes place, they almost always abort. 4. Incapacity for Gestation. — This condition is often combined with the incapacity for conception, barrenness alternating with abortions APPENDIX. 721 and miscarriages. An inflamed endometrium, for instance, offers a poor soil for the growth of an ovum, so that fetal development is likely to be arrested, the pregnancy ending in a miscarriage ; but the ovum may also be washed out by hemorrhagic and leuconheal dis- charges, before it ever becomes imbedded, and perhaps before it is fertilized. Diagnosis. — Fecundity depending upon the union of elements derived from two individuals, it is proper in a case of sterility to look for the cause or causes in both persons concerned ; but, unfortunately, it happens that the husband, while he is quite willing to submit his wife not only to the most searching physical examination, but even to operative procedures, absolutely refuses to be examined himself. There is, sometimes, a lingering doubt in his mind that the i'ault might be on his side, and he dreads above all to acquire this certainty, or at least to let his wife know it. If he is Milling to give the neces- sary information, he should, first of all, be questioned in regard to copulation, ejaculation, syphilis, and gonorrhea. The proper pcjsition of" his meatus urinarins should be ascertained. His urethra should be carefully examined with a bougie-a-boule or an endoscope as to caliber and small pus-secreting surfaces lurking behind strictures. Finally, his semen must be examined microscopically. The proper way of obtaining it unmixed with foreign substances is to let him have intercourse with his wife, using a condom. Immediately after copulation tliis bag with its contents is thrown into a wide-mouthed bottle and brought to the physician, who examines it without delay. If the man's semen is full of living spermatozoids, the examination may be extended to the woman, in order to find out if there be any discharge in the vagina that kills the spermatozoids. For this pur- pose the husband should be allowed to have normal intercourse with his wife, and shortly after the act a little semen should be removed from the posterior vault of the vagina with a Simon's spoon and examined microscopically. Often it suffices, however, to examine the woman without having recourse to tliis somewhat re})iigiiant procedure. In examining the woman, the physician will bear in mind all the malformations and diseases just enumerated that may entail sterility. TIk! vaginal secretion sjjould be tested witii litmus-paper. It is nor- mally acid, bnt it may be so to such a degree that it kills the sperma- tozoids. Ft should also be examined microscopical ly for ])Us-cor])Us- cles, th(; presence! of which always shows inflammation. 1'Iie utero- tubal nuicus is oi)tained by introducing a s|)eculnm and taking the nuiciis directly out of the cervical canal. This is normally alknline, and any acid fluid is deleterious to the spermatozoids. Trcfdinnif. — In regard to the treatment of the man tiie reader is refern'd to works on venereal diseases. 46 722 APPESDIX. Often a certain mutual adaptation seems to be necessary. Nothing is more common than that impregnation does not take place immedi- ately upon entering upon marital relations. iSIany months may even ela])se before it occurs between perfectly healthy individuals. A little patience is, thei'efore, always to be recommended. But, on the other hand, accurate statistics have shown that three-fourths of married women get a child in the coui*se of the first year of their marriage, and that if three years elapse without offspring the chances of hav- ing children become very small. As a practical rule, we may say that if a woman does not conceive during the first year of her marriage, and wishes to become a mother, she had better seek med- ical advice. The entrance of the semen into the uterus may be favored by rais- ing the pelvis during copulation or by coition modo hrutonvm. Trav- eling has a marked influence, which may be due to climatic influ- ences, change of diet, or, more likely, the diversity of couches. The causes of sterility in the female being so manifold and com- prising most of the malformations and diseases treated of in this work, the treatment will, of course, also vary much, the general rule being to remove, if possible, whatever cause or causes we may find by the means indicated in the preceding chapters. Anemia is treated with carnogen, iron, manganese, strychnine, cod- liver oil, terraline, and a diet in which albuminoids preponderate, and into which enters the use of milk, beer, or wine. Adipose tissue is reduced by iodine, fiicus marina, phytolacca, exercise, massage, Turkish baths, and a diet from which sweets and cereals are nearly excluded, and in which liquids are limited as much as possible.^ A too small uterus may sometimes be enlarged by the galvanic current. Many different operations maybe called for in order to remedy sterility. The labia may have to be separated ; a resistant hymen removed ; a painful caruncle destroyed ; a vagina made ; or an elon- gated cervix amputated. The cervical canal may require dilata- tion, which may bo kept up by the use of Outerbridge's ])ermaneut dilator (p. 192); a polypus may have to be cut oft'; a spongy endo- metrium may need curetting, etc. Sometimes the operation required is not one of division, but of union, as when a torn perineum and vagina are rej)aired or trachelorrhajihy is performed. A torn cer- vix would seem to favor impregnation by offering freer entrance to ^ Such a diet should l)e composed of beef, mutton, veal, pork, game, poultry, eggs, fish, lobsters, crabs, shrimps, oysters, clams, scollops, muscles, cheese, green vegetables, lettuce salad, and a small amount of juicy fruit, with a j^int of claret or Moselle wine, a cup of lilack coflee, a cup of tea without milk, and four ounces of bread per day. Butter and other fats are harmless. Forbidden, on the other hand, are soups, water, milk, Ijeer, jjotatoes, beets, puddings, pies, and other sweet dishes, as well as bananas. APPENDIX. 723 the interior of the womb ; but, on the other hand, the endometritis following the tear is a bai'rier to conception ; and, as a matter of fact, I may state that I have repeatedly removed sterility by this operation. Laparotomy or colpotomy will hardly be undertaken for sterility alone, since it would risk an existing life in the uncertain hope of rendering another possible ; but when it is undertaken for legitimate causes, it may perhaps even cure sterility, if the operator finds it pos- sible to leave one or both ovaries and render the tubes permeable (p. 562). When all other means fail, or no cause for the sterility can be found, or the woman refuses any kind of cutting operation, we may yet try artificial impregnation. Since the fundamental condition of fecundity is the union of a s})ermatozoid and an ovum (p. 123), since in most cases it is an easy matter to introduce semen all the way up to the fundus of the uterus, and since artificial fertilization is used on a large scale in pisciculture, one would think that artificial impregna- tion of a woman could likewise be performed without difficulty. But it is not so. It has been tried many times, but has nearly always proved a failure. The operation is very simple. The semen of the husband having been found normal, and especially after ascertaining that it does not contain pus-corpuscles, he has intercoui'se with his wife, using a con- dom. This he brings to the physician waiting in another room. The latter has in readiness an intra-uterine syringe (p. 176), properly disinfected and kept warm. He sucks a small amount of semen up with the syringe, exposes the os uteri with a speculum, wipes it ofi' with cotton dipped in some antiseptic fluid, introduces the nozzle up to the fundus, and expresses a few drops slowly into the interior of the womb. The woman should stay in lx;d on her back, and if she feels any pain an ice-l)ag should be a})plied to the hyj>ogastric region. The most favorable time for performing the operation is shortly before menstruation is expected, and the next best period is imme- diately after the catameiiia (p. 125). It may, of course, be repeated during several months, if the first attempt does not succeed. 11. LACK OF ORGASM. A coxDiTrox for which we are not infVofpicntly consulted is lack of the noi'inal feeling oi" the highest sexual excitement called orgasm (p. 123), lioth the husband and the wife (lei)lore a defect which deprives the marital relation of its highest ])hysical satisfaction, and some knowing women, in order to retain their husbands' affection, 724 APPENDIX. simulate a state wliich does not exist in reality. Some women have never felt this sensation. With them the fault is congenital, and is probably due to some imperfection in the central nervous system. Others know the sensation from previous experience,tbut have lost the faculty of feeling it. Some feel it dreaming, but never during intercourse. The lack of orgasm, both the primary and the second- ary, may be found in otherwise perfectly healthy women, and is not a barrier to conception. Primary lack of orgasm is incurable, and it is very doubtful if the acquired form allows us to give a better prognosis. In my own practice I have constantly failed with the use of tonics, the galvanic current, and aphrodisiac drugs, such as damiana, phosphorus, and cantharides. III. INTESTINAL SURGERY. In operations on the internal genitals, especially ovariotomy and salpingo-oophorectomy, the gynecologist is sometimes incidentally forced to operate on the intestine. A short description of the chief operations of this kind, such as resection, lateral anastomosis, end-to- end approximation by artificial invagination, the use of the intestinal button, and the removal of the appendix vermiformis, may, therefore, not be out of place here. A. Resection of Intestine. — The bowels are squeezed empty for five or six inches in either direction from the part to be removed and compressed with special forceps (Murphy), a safety-pin and sponge (Maunsell), a strip of gauze, or an elastic ligature carried through a hole in the mesentery and tied round the intestine. The intestine is cut across, and the mesentery is treated in one of two ways, either by excision or by folding. Either a wedge is cut out, the base of which corresponds to the piece of intestine to be removed, and the apex to the root of the mesentery ; next, the two edges are stitched together, according to the thickness of the mesentery, by a single running su- ture or by a double, stitching each layer of the mesentery separately. Or the mesentery is cut along the piece of intestine to be removed, using blunt scissors, and separating the peritoneum as much as pos- sible from the intestine before cutting it. When the ends of the intestine iiave been brought together, the edge of the mesentery is doubled up and stitched together, and tiie flap formed in this Avay is itself fastened to the remainder of the mesentery with a few stitches. B. Lateral Anastomosis} — A part of the intestine having been resected, each end of the inverted gut is closed with a double row of continuous sutures with fine black silk. Next, the mesentery is ' Robert Abbe, Med. Record, April 2, 1892, vol. xli. p. 365. APPENDIX. 725 divided sufficiently to draw tire ends of the severed gut past each other, so as to make thera overlap for six inches (Fig. 364). In this position they are sutured together by two rows of Lembert sutures, a quarter of an inch apart, carrying a running suture of finest black embroidery silk with a cambric needle. Half a dozen such needles should be threaded with silk threads twenty-four inches long, and the silk tied to the eye of the needle with a simple knot, leaving a short end two inches long. The lines of sutures are made about five inches long, and the two needles are left on their silk threads. Next, an incision four inches long is made with scissors in both ends of intestine, a quarter of an inch from the nearest of the two sutures, applying hemostatic forceps to bleeding jwints. Next, another over- hand suture is started at one end of the incision, uniting the two edges nearest the previoiis sutures, and penetrating both serous and mucous coats, which arrests hemorrhage. This suture is then contin- ued round each of the two free edges separately. Finally, the needles Fifi. 304. Fig. 3r..-> Abbe's Intestinal Ana=;tomosis. MnunseU's Intestinal Invufiination : n, a. tenii)()rary suturos; 6, needle carry- ing horsehair. of the first two sutures are taken up one after tiie other, and used to complete the double row of Lembert sutures around the opening made in the intestine. There is no doubt of the excellence of this opcratiou, but in order to l)e |>erformed within a ren.^onable time it (leninnds a hand u.-^ed to that kind of work. Dr. Halsted of Baltimore says that the peritoneal coat of the in- testine is so thin that it is impossible to suture it alone, and even sutures comprising the ]M'ritoneum and the niuscularis tear out easily. A thread of the strong fibrous subrnurosa should be included in the stitch. This coat is recognized by the resistance it offers even to th<' point of a fine needle. It is air- and water-tight, and is the skin in which .suisag<.' meat is stuffed and of" which catgut is made.' (.'. Kn(J-t()-r)ul Apjn'oximdtion hj/ Arfiflcid/ I inutt/iuitfitm.- — "^Pwo teniporary sutures are placed, one at the nicsenterv and one just oppo- ' W. S. Halste.l. riilhi.l.'lphin Mnl. Jour.. IS'.tS, vol. i. No. 2. |>. ('.4. '' H. Wideiihani Maiinsell, Amer. Jour. Mid. i'c/., Marcli, IS'.CJ, p. 245. 726 APPENDIX. site, carrying tliem throusxli nil three coats of tlic two ends of the severed intestine. Next, a lonijitndinal liole, one and a half inches long, is cnt in the larger part of the intestine one inch from the end, and the two tenipornrv sntnres are hanled out through this opening, carrying the end of the intestine after them. Ten horsehair or silk- worm-gnt sutures are now carried through both walls of intestine (Fig. 365), picked up in the middle, and cut, thus forming twenty sutures, which then are tied. The temporary sutures are removed. Next, the invaginated portion of intestine is hauled back, and the longitudinal opening closed with a running silk suture through the serous and muscular coats only. This is a reliable operation, and not particularly difficult. D. Murphy's^ Button (Fig. 366). — Through the ingenious device of Dr. ^Murphy of Chicago we are now enabled to do away with enterorrhaphy altogether. It consists of a set of four button-like contrivances, one of which is chosen according to the different sizes of the intestines to be united. Each button consists of a male and a female half. The female half, again, is composed of a cen- tral cylinder that has a shallow screw thread on its inner surface and a wide bowl-shaped flange with five large holes for the passage of gas. The male half is composed of a similar central cylinder with two small fe- nestrse, through which pass two small pro- tuberances fastened with springs to the in- side of the cylinder. The tube has a similar perforated bowl-shaped flange to that of the female half, but besides that it has a mov- able ring surrounding the central cylinder and fastened to the bottom of the bowl with a spiral spring. This male half fits in the female, the lateral prominences adapt them- selves to the screw thread, and the ring ex- ercises a pressure on the rim of the intestine comprised between the two halves of the button, producing constant approximation and ultimate absorption, while adhesive in- flammation closes the line of union between the two pieces of intestine, ^yhen this pro- cess is finished, the button is carried down through the intestine and expelled through the anus, usually in the ^ John B. Murpliv of Chicago, 111., North American Practitioner, Nov. and Dec, 1892 ; New Yurk Med. Record, May and June, 1894. Murphy's Int ton ( enlarged closed. APPENDIX. 727 Fig course of the second or third week. There is a linear cicatrice, and the bowel retains an opening as large as that of the button used. The Murphy button can be used both for lateral anastomosis and for end-to-end adaptation. For lateral anastomosis the ends of the in- testine are closed with a double row of Lembert sutures, as in Abbe's operation. A needle with a silk thread, fifteen inches long, is inserted in the bowel opposite the mesentery, and a stitch taken longitudinally through the entire wall of the gut one-third the length of the incis- ion to be made. The needle is again inserted one-third the length of the future incision from its outlet, in a line with the first. A loop of the silk, three inches long, is held here, and the needle is again in- serted, making two stitches parallel to the first two, a quarter of an inch from them and o-oing in the reverse direction. This forms the running thread, which when tightened draws the incised edge of the gut within the cup of the button. A sim- ilar running thread is placed on the other end of the gut. A hole is cut inside of the suture, which hole should not be longer than two-thirds of the length of the diameter of the button used. The lig- atures are tightened round the central cyl- inders, the two halves of the button are pressed together, and the intestine dropped into the abdominal cavity. In inserting the male half into the intestine the movable ring should be pressed down to a level with tlie flange, and this should be grasped with a forceps and held while the first half of the knot is ijeini; made. When the jriit is drawn dose about the central cylinder, the forceps is changed to the edge of this cylinder and the knot is completed. In the end-to-end adaptation each half of the button is inserted in one end, but before so doing a running suture is intro- duced in such a way as to prevent the cver- sion of the mucous membrane and insuring the overlapping of the mesentery. This is (jbtained by beginning at a opposite the ines- ent(,'ry, using a top stitch along the incised edge, taking a return over-stiteh (h) at the mesent(!ry, and eoiitinuing the toj) stitch on the opposite side, l)aek to the starting-point (Fig. ••MM). This method is tlu' simplest and most expeditious one of all Mnnnoi- of Insortiii!,' Rnntiiiiff siituro in Kiid of Intestine (Mur|)liy) : <i, start i M),'-|ii lint ; b, return oVLT-stitch ul mus- entery. 728 APPENDIX. E. Ecphyadcdomri, ftcolccectomj/, or removal of the appendix vcrnii- formis. If in pcrforniino; laparotomy the appendix Aermiformis is found diseased, it is projier to remove it. A continuous Lembert suture of silk is made to surround the appendix, running like a purse- string in the superficial layers of the cecum one-fourth of an inch from the appendix. The suture is not tightened, but only half of a surgeon's knot is made. Next, the appendix is divided, leaving a stump at least half an inch long. This stumj) is stretched by intro- ducing a pair of fine forceps through it into the cecum and opening it gently. With another pair of fine mouse-toothed forceps the stump is invaginated and carried into the interior of the cecum. And, finally, the suture around its base is tightened over it.^ ^ Dawbarn, International Journal of Surgery, 1895, vol. viii. No. 8. INDEX. Abbe, intestinal anastomosis, 725 Abdominal hysterectomy, 451, 517, 549 regions, 115 section, 641 wall, adherent to ovarian cyst, 653 Abortion, cause of disease, 135 Abortionist, 414 Abscess — after ovariotomy, deep, 669 mural, 669 of vulvovaginal gland, 309 ovarian, 591 pelvic, 701 Accessory abdominal ostia of Fallopian tube, 553 A. C. E. mixture, 222 Acid — carbolic, 197, 211, 290, 312 hydrocyanic, 227, 287 sclerotinic, 506 Actinomyces, 558 Adenoma — benign, 428, 492 malignant, 428, 492 uteri, 492 Adhesions ovarian, 585, 597, 641 peritonitic, 704 severance of uterine, 476 tearing of, 473 Aftor-treatmer)t, 239 after ovariotomy, 651 complications during, 667 Air-pressure, 467 Ala vesjKTtilionis, 2(5. 67 Albugincii, 27, 71 Alcohol for disinfection. 209 Alcxunder's operation. 471 Alinicntation, rectal, 241 Allantois, 32 Alligator forceps, 648 Allongfincnt of polvpu.s, ">05 Aloes. •_'J2 Ameboid bodies. 612 Airienorrhca, 255 proiMT, 256 Aincncan method of hy.sterectomy, 519 Ampulla — of Fallopian tube, 66 rectal, 87 AmputatiiMi — of cervix, 438, 448, 449, 464 of inverted uterus, 490 supravaginal, of uterus. 517. (See Hysterectomy. ) Anal region, 101 Anatomy, 35 Anesthesia, 218 causing nephritis, 220, 530 paralysis, numbness, or pain, 208 for examination, 162 in elevated-pelvis position, 221 Aneurysm of uterine artery, 679 Angioma — of uterus, 493 of vulva, 300 Anodynes. 243 Anteflexicm, 413, 458 acquired, 459 cervical, 458 cervicocorporeal, 458 congenital, 459 corporeal, 458 deyelo})mental, 459 Garrigues' oj)eration for, 462 irreducibb;, 458 reducible, 458 salpingo-oophoi-ectoniv, 464 Sims's operation for. 463 Anteposition, 453 Anterior commissure. 36 Antevei'sion, 453 ojx'nilions for, -157 Aiiliblennori'liagic drugs, 368 Anlidysmenorrheal drugs, 263 Aiitiphlogistine. I'.to Antipyretics, 245 Antisejisis, 209 Antiseptic — fluids. 217 material, 209 Anns, preternatural, 400 Aperients, 241 Apostoli, electrode, 248, 249 729 730 INDEX. Apostoli, method, 250 Applications, 175 Applicator, Garrigues', 175 Arhor vita^. 40 Arch, tendinous, !t(J Aristol. 217 Arnold, sterilizer, 209 Arteries — circular, (51 lielicine, 01 ligation of internal pudic, 189 of uterine, 188 of perineal region, 107 of uterus, 00 Artificial impregnation, 723 prolapse of uterus, 145 Ascites, 019, 028, 033, 065 Asepsis, 209 Ashton, speculum, 152 Aspermatism, 718 Aspiration, 101, 197 exploratory, 161, 629 through vaginal vault, 573, 629 Aspirator, 170 Dieulafoy's, 170 Emmet's, 170 Potain"s, 170 Assistants, 204 Asthenopia, 130, 429 Atresia — acquired, of uterus, 440 of vagina, 348 ani vaginalis, 354 vestibularis, 354 case of, 350 hvmenalis, 345 of urethra, 392 of uterus, 410, 440 of vagina, 347 acquired. 348 combined with double vagina, 353 complete, 347, 353 congenital, 348 incomplete, 347 Atrophy of uterus — acquired, 451 puerperal, 451 senile. 451 Atropine injected suhcutaneously before anesthetizing, 222 Auscultation, 101 Aveling, repositor, 489 Azoospermatism, 718 Azoospermia, 718 Azoospermisui, 718 Balloon I x(;. 148 Bandl. operation for ureterovaginal fis- tula, 393 Barnes, operation for inversion, 490 replacement of inverted uterus, 489 Bartholin's gland. (See Vulvovaginal Gland. ) Barton, Khea, operation for rectolabial fistula, 401 Base of bladder, 80 Baths, 195 general, 195 Russian, 195 sea-, 196 sheet-, 196 shower-, 196 sitz-, 196 sponge-, 196 steam-, 196 towel-, 196 Turkish, 196 Bath-speculum, 195 Battev's operation, 564 Bed, 202 Beef-juice, 240 Beef-tea, 240 Belladonna. 287, 433 Belt, abdominal, 199 Bernays, uterotractor, 547 Bichloride of mercury — for pai'enchymatous injection, 545 internally, 242 standard solution, 217 Bicycling, 201 Bimanual examination, 144 replacement of uterus, 468 Bipolar electrodes, 247 Bismuth, 242 Bisulphide of carbon, 720 Bladder — adherent to tumors, 525, 653 anatomy, 80 catheterization, 39, 162 distention. 036 fetal, in adult, 83, 523 function, 83 irrigator, 179 irritable, 429, 433 Blasius, operation for fistula, 389 Blind canals in vagina, 353 Blister, 190 Bloodletting, 194 Blood-pressure increased before menstru- ation, 119 Bode, vaginal shortening of round liga- ments, 476 Bodies, ameboid, 012 AVolffian, 20 Body, jierineal, 100 of womb. 48 Boldt, ]»lunt pelvic dilator, 001 table, 203 INDEX. 731 Boucies with iodoform, 426 Boves uretero-ureteral anastomosis, 655 Bozeman, button, 388 dilator, 374 operation for fistula, 388 scissors, 505 speculum, 388 table, 388 urinal, 398 Brandt, Thure, cure for prolapse, 480 cure for retroflexion, 473 Braun, syringe, 176 Breisky, pessary, 480 Brewer, speculum, 147 Broad ligament — cysts of, 681 diseases of, 680 during pregnancy, 58 solid tumor of, 684 varicocele of, 680 Broca's pouch, 37 Bubo, 312 Bulb, vestibulovaginal, 39 Bureau, operation for fecal fistula, 403 Burning sensation in genitals and abdo- men, 293 Burrage, speculum, 152 Button, Bozeman 's, 388 Murphy's, 726 Byrne, carcinoma uteri, 546, 547 Calcikkatiox — of corpus lutcum, 595 of ovarian cyst, 620 of uterine fibroid, 500 Calcium carbid, 544 Calculus due to suture, 391 Camj)hor — emulsion, 371 in collapse, 224 Canal — anal, 87 cervical, 50 Gartners, 20, 378 of Xuck, 37, hf'matoccle of. 281 Canals, blind, in vairina, 353 Cancer — carried through lym|ib-vesscl>, 675 definition, 531 of Fallopian tube, 579 of jjoritoncum, 634 of vulva, .'!()2. (See ('iircin(fi)in and S(i ri'(i])iti. ) Canfor-c(ll< in a>ritic tluid accompany- ing malignant tumors, 542 Capsub' of tibroid tumors, 494 Carbon bisulphide, 720 Carcinoma — in negro race, 537 not transmissible by coition, 538 of body of uterus, 536 of cervix, 536 of Fallopian tube, 579 of ovarian cyst, 610, 620 of ovary, 675 of pelvis, 714 of uterus, 536 of vagina, 381 of vaginal portion, 536 of vulva, 302 syncytiale. 537 Carnogen, 242 Carrier, 232, 420, 504 Caruncle, urethral, 300 Canuiculic myrtiformes, 47 Catamenia, 117 Cataphoresis, 250 Catarrh — of uterus, 430 of vagina, 364 Catgut,'^212 buried, 329 chromicized, 214 sterilized with alcohol, 213 cumol, 214 dry heat, 214 formalin, 214 Catheter — double-current, 178 self-retaining, Pctzer's, 513 Sims's, 387 Catheterization — of bladder, 39, 162 of Fallopian tube, 562 of ureter, 165 Cauliflower excrescence, 536 Cauterization, 187 galvanochemical, 247, 248 gal va?iot hernial, 252 bemostatic, 186 of fistula, 385. 402 Cautery-ciamp, 648 Cavity — of uterus, 49 liclvipcritoncal, 96 Celibacy — in relation to disease, 131 to uterine fibroid, 500 '•(".•liofomv," 644 Cells, proliV.'rating, 612 Cellulitis, 6:;(i anterior, 708 chronic atrophic, 710 ])elvic, 705 posterior. 708 Cervical canal, 49 732 INDEX. Cervical carcinoma, 530 gaiiEjliou, (i5 speculum, 152 stenosis, 441 Cervicitis, 423 Cervix, 48 amputation, 438, 448, 449. 404 cone-niantle-shaped excision, 439 concjenital cleft, 417 conical, 441 cyst^, 433, 492 development, 32 discission of posterior lip, 403 elongated, 414, 445 fuTinel-shaped excision, 447 high amputation, 448, 449 laceration, 415 single-dap excision, 439 stenosis, 441 supravaginal amputation, 448, 449 . ulcers, 444 wedge-shaped excision, 438 for retroflexion, 460 Chain-ligature, 602 Chancre^ 312 hard, 312, 444 mixed, 313 soft, 310 Chancroid, 310, 444 chronic, 296, 311 Change of life, 125 Charts, 101 Chian turpentine, 545 Childbirth, cause of disease, 132 Chloral hydrate, 288 Chloride of zinc, 174 for cauterizing carcinoma of uterus, 543 Chloroform, 222 embrocation, 243 -mask, 222 Cholesterin, 613 Cicatrices in vagina, 373 Circular artery, 61 Cirrh(jsis of ovary, 591 Clamji — compared with ligature, 514 Ko'lierle's, 191 method for hysterectomy, 511 Cleanliness, 142 a cure fur fistula, 385, 401 Cleveland, ligature-carrier, 233 table, 203 ' Climacteric, 125 treatment, 127 Clitoridectomy, 319 Clitoris, abnormal, 274 absent, 274 amputation, 319 Clitoris, anatomy, 38 development, 34 enchondroma, 300 function, 39 horn, 300 Cloaca, 34 persistent, 354 Cloacal o))ening, 34 Closure of uterus, 440 Clover's crutch, 207 Clyster, 178 Coalescence of labia, 276 Cobbler's stitch, 649, 602 Cocaine, 223 bougies, 370 Coccygectomy, 343 Coccygodj'nia, 342 Coccyx — anatomy, 342 extirpation, 343 Coe, improvement on Lefort's operation, 482 • preventive excision of cervix, 542 Coffee against vomiting, 224 Coil, 195 Coition — during menstruation, 132 modo brutorum, 722 Cold, 195 ■ Cole, administration of oxygen with ether, 218 Cole}' mixture, 714 Colica scortorum, 558 Collapse, 223, 224, 529 Collector, 249 Colpeurynter, 489, 504 Colpitis, 303 Colpohyperplasia cystica, 369 Colpoperincorrhaphy, 327 Colporrhaphy — anterior, 350 bilateral, 357 lateral, 357 median, 357 posterior, 300 Colpotomy, 5r)3 anterior, 475, 510, 513 posterior, 510, 513, 702 Columns — of Morgagni, 90 of vagina, 43 Comparison between ligature and forceps in vaginal hysterectomy, 515 between oj^erations for retroflexion, 470 between total extirpation and supra- vaginal amj)utation of uterus, 525 between vaginal and abdominal section for carcinoma of uterus, 549 INDEX. 733 Comparison between vaginal and abdom- inal section for fibroid of uterus, 529 for salpingo-oophorectomy, 569 Conception, incapacity for, 719 Condurango, 544 Condylomata acuminata, 296 Cone-mantle-shaped excision of cervix, I 439 I Conium pills, 243 Connective tissue, pelvic, 95 i Consent of patient necessary for opera- ' tions, 504 I Conservative treatment of appendages, i 563, 596 Contents, 5 Copeland, method of arresting vomiting, 201 Copiopia, 205 Copulation, 123 incapacity for, 719 Corporia arenacea, 615 Corpus — albicans, 77 cavernosum of clitoris, 38 luteum — calcified, 595 changed into cyst, 595 into gyroma, 598 false, 77 of menstruation, 74 of pregnancy, 75, 599 ossified, 595 verum, 599 nigricans, 77 nigrum, 77 uteri, 48 Corpuscles — lienneft's large, 611 small, 612 colloid, 611 iJrysdale's, 612 genital, 39 gorged, 611 Niiiiri's, 611 Corroding ulcer of cervix, 444 difl'erent from rodent ulcer, 540 Corset, i:!l Cortical substance of ovary, 71 ottnii, styptic, ISO otiiiter-irritalioii, 196 outlier-pressure liook, 235 our~cs, 1 17 otirty, inversion, 490 ramps, 124 reuliii, 177, 217 rn-hy, needle-liolder, 232 nis of clitoris, 3M urettage, \X0 Curettage for uterine fibroids, 508 Curette, 156 Kecamier's, 182 Simon's, 156 Sims's, 156 Thomas's dull-wire, 156 Current — constant, 249 interrupted, 249 Cusco, speculum, 152 Cyst— of abdominal wall, 635 of broad ligament, 631, 634, 681 of cervix. 433, 492 of Fallopian tube, 578 of liver, 634 of mesentery, 635 of omentum, 634 of ovary, 606 of pancreas, 635 of spleen, 635 of uterus, 488 of vagina, 378 of vulva, 301 of vulvovaginal gland, 308 ovarian, 606 parovarian, 680 renal, 034 tubo-ovarian, 017 Cystocarcinoma of ovary, 675, 676 Cystocele, 356 Cystoma of ovary, 615 dermoid, 615 glandular, 606 . mvxoid, 005 papillary, 000, 014 Cystopexia, 300 Cystosarcoma of uterus, 532 Cystoscope, KiO Czerny, ventrofixation, 474 Czerny-Ijcmbert suture, 053 Daktos, woman's, 37 Davidson, svringe, 175 Death- after hysterectomy, 529 after ovai-iotomy, 071 from chloroform, 220 Decidual sarcoma, 5:)4 Dcciduoma malignum, 534, 537 Decuhitus acutus, 538 Depressor — durrii^ues', 151 Hunters, 149 Sim-s, 1 J!) va-iiniil, 149 Dermoid cvsf - of ovary, •>15 out>ide of ovary, 017 734 INDEX. Descent — of ovary, 23 of uterus, 478 Detrusor of rectum, 87 Development — arrest of, of uterus, 400 excessive, of uterus, 406 irrejijular, of uterus, 413 of t^ie cervix, 82 of the female <j;enitals, 19 of the hymen, 33 of the ovaries, 22 of the uterus, 31 of the va<xina, 31 of the vulva. 31 Diaphragm, pelvic, 97 Diet- after operations, 239 tiuid, 239 for reducing fat, 722 Dieulafoy, aspirator, 170 Digitalis for reviving, 223 Digital pressure for replacing uterus, 468 Dilatation — of cervical canal, 156, 192 of urethra, 144, 165 of uterus, 158 of vagina, 348, 350 Dilator — hlunt pelvic, 661 Garrigucs', 157 Goelet's, 158 Hanks's, 157, 158 olive-shaped, 159 Outerhridge's. 192 puncturing, 198 vaginal, 348, 350 Discus proligerus, 28, 73 Disease, gelatinous, of peritoneum, 621 Diseases — exanthematous, 290 of broad ligament, 680 of Fallopian tube, 554 of ovary, 581 of pelvis, 679 of perineum, 320 of round ligament, 684 of sacro-uterine ligament, 684 of uterus, 406 of vagina, 345 of vulva, 273 of vulvovaginal gland, 308 venereal, 310 Disinfection, 200 by steam. 209 internal. 404 of catgut, 214 of instruments, 239 of laminaria tents, 157 Disinfection of silk, 213 with boiling soda solution, 210 Disj)lacement — of Fallopian tube, 578 of ovary, 583 of uterus, 453 Distribution of organs between perineal fascia;, 112 Douche-can, 175 Douglas's pouch, 94 prolapse of intestine into, 354 Dowd, sterilizer for catgut, 213 Drainage — abdominal, 192, 194, 666 after (jvariotomv, 666 of uterus, 192, 193 -tube, 193 vaginal, 667, 670 with iodoform gauze, 192 with rubber tubes, 193 Dress, 130 Drink, 240 Dropsy of Graafian follicle, 601 Duct, 'Miillerian, 29 Wolffian, 19 Dysmenorrhea, 259 membranous, 259, 435 nervous, 259 obstructive, 441 Dyspareunia, 123 Dyspepsia, 241 EcHixococci, 715 Ecphvadectomy, 728 Ectropium, 416, 427 Edebohls, table, 203 Edema — indurating, 304 of abdominal wall, 635 of lacerated perineum, 325 Education, 129 Ehrich, speculum, 151 Elastic ligature, how to tie, 518 pressure. Electricity — Apostoli's method, 250 bipolar electrode, 247 chemical, 247 galvanocauterization of the cervix, 251 different qualities of poles, 250 frictional, 246 high-tension coil, 247 inductional, 246 molecular ni(jvement. 250 Electrode — aluminium. 248 .Apostoli-s, 247, 248 bipolar, 247 INDEX. 735 Electrode — Engelmann's, 248 Fry's, 443 Garrigues', 249 gas-carl)on, 250, 251 Martin's, 248 platinum, 248 Electrolysis, 253 for stenosis of cervix, 443 inetaliic interstitial, 253 Elei)hantia.sis of vulva, 297 Elevation of uterus, 485 Elytritis, 303 Emmenagogues, 257 Emmet, Bache, trocar-forceps, 702 Emmet, T. A., aspirator, 171 button-hole operation, 31ti counter-pressure hooi<, 235 operation for fecal tistula, 404 for inversion, 490 for lacerated cervix, 419 for uterine flbroid, 509 for vaginismus, 377 for vesico-uterine listula, 395 perineorrhaphy, 332, 339 pessary, 409 tenaculum, 227 trocar, 040 wire-twister, 235 Emphvsema, 669 Ems, 197 Emulsion of camphor, 371 Enchondroma — of clitoris, 300 of uterus, 551 Encysted ])eritonitic exudation, 033 Endocervicitis, 423 Endometritis, 423 atrophic, 429 catarrhal, 427 chronic, 427 decidual, 429 exfoliating, 435 fungous, 427 hemorrhagic, 429 hyj)erj)lastic, 427 menstrual, 435 Endosaipingitis, 554 End<ithelii)ma (Ackermann) of ovarv, 599, (i74 f. Jones) of f)vary, 597, 599 Ein-ma, 178 tuitrient, 241, 007 Engflmann, electrode. 248 rt'trai'tor, 227 Enterocf'le, vaginal, -'{51 Emiclcation — alxiominal, 525 from broad liirament, 520 Enucleation — from pelvic floor, 527 from uterus, 528 Miner's method, 657 of uterine fibroids, 508, 525, 526 vaginal, 508 Enuresis, operations for, 359, 398 Epididymis, 22 Epispadias, 274 Epithelial coalescence of vulva, 276 Epithelioma of vulva, 302 Erection, 123 of internal genitals, 58 Ergot, hvpodermically for fibroids, 507 Ergotine, 507 Erosions, 433, 444, 507, 542 Erysipelas of vagina, 373 Esmarch's mask, 222 Esthi(^mcne, 303 Ether, 218 chloric, 223 Ethyl chloride, 223 Examination — bimanual, 144 chemical, 101 combined, 144, 145 digital, 141 for sterility, 722 in general, 134 in regard to operations, 206 intestinal, 144 microscopical, 102 of abdomen, 100 of bladder, 102, 558 of i)elvis, 141 of uretei-s, l'i5 of urine, 101 of uterine aj)))endages, 558 of virgins, 159 physical, 137 rectal, 144 under ane-tliesia, 109 vairinal. 142 verbal. 134 ve-ical, 144 Exaiitlienuitous disea,ses, 290 P^xcitor — bipohir, 247 uterine, 247 vaiiiiiai, 247 Kxcretions, 130 Kxercise, 129 Exploratory — aspiratioii. 101. (;'J9 inci.-ion, lOl. 0:'.<l iapanitomy. 573 )iun('tiire. 029 F^xtniets of meat. 241 736 INDEX. Extraperitoneal shortening of the round ligament, 471 Extra-uterine pregnancy, 631 Facies ovariana, 62") Falling of the womb, 478 Fallopian tubes — absence of, 553 accessory, 553 anatomy, 65 caTicer, 579 carcinoma, 579 catheterization, 562 cysts, 578 development, 30 diseases, 554 displacement, 578 examination, 558 fibroma, 578 function, 68 lipoma, 579 malformation, 553 neoplasms, 578 palpation, 558 papilloma, 579 relation to menstruation, 118, 120 sarcoma, 579 tuberculosis, 579 Faradism, 247 Faradization of diaphragm, 224 Fascia — anal, 97, 103 deep perineal, 102 distribution of organs between peri- neal fasciae, 111 levator, 103 obturator, 96 pelvic, 96 perineal, 102 pyriformis, 96 superficial perineal, 102 vesicorectal, 96 Fat— -granules in ovarian cysts, 613 preperitoneal, 645 retropubic, 95 Faure, hysterectomy, 568 Fecal fistula after ovariotomy, 670 Feces, impacted. 636 Fecundation, 123 Fergusson, speculum, 146 Ferripyrine, 174, 186 Fertilization, 123 Fibrocyst of ovary, 567 of uterus, 607 diagnosis, 632 treatment, 530 Fibroid — of uterus. 494, 631 Fibroid — of uterus, calcification, 500 causes of death from operations, 529 complication with pregnancy, 527 diagnosis from ovarian cyst, 632 indications for operations, 530 loose, 498 migrant, 498 mortality after operations, 528 sloughing, 528 of vagina,379. (See Fibroma, Myoma. ) Fibroma — molluscum, 300 of Fallopian tube, 578 of ovary, 672 of round ligament, 283 of uterus, 494 of vagina, 379 of vulva, 299 case of pedunculated, 300. (See Fi- broid, Myoma.) Fibromyoma — of uterus, 484 of vagina, 379. (See Fibroid, Fi- brom.a.) Fibrosarcoma of ovary, 674 Fimbria ovarica, 66 Fimbriie — anatomy, 66 development, 30 Fistula, 383 abdominal method, 391 Bandl's method, 393 Barton's method, 402 Blasius's method, 389 Bozeman's method, 388 Bureau's method, 403 combination of methods, 392 congenital rectovaginal, 354 denudation, 386 Emmet's method, 395 entero-vaginal, 399, 404 fecal, 399_, 670 flap-splitting methods, 389, 404 Follet's method, 395 Fritsch's method, 403 ileo-uterine, 399 ileovaginal, 399 Pozzi's method, 394 produced by coition, 283 rectolabial, "399 rectovaginal, 399, 402 rectovulvar, 399 Schede's method, 394 Simon's method, 388 Sims's method, 386 suprapubic method, 389 Taylor's method, 403 Trendelenburg's method, 389 INDEX. 737 Fistula, uretero-uterine, 390 ureterovaijinal, 391, 395 urt'terovesicovaginal, 390 urethrovaginal, 392 urinary, 383 uterovaginal, 41G vesioo-uterine, 395 vesico-uterovagiiial, 396 vesicovaginal, 3S;5 Vignard s method, 403 Wsilcher's metliod, 890 Fistulous tract, (iTU, 704 Flap-operation for atresia, 350 Flap-sliding metliod for rectovaginal fis- tula, 404 Flap-splitting perineorrhaphy, 327 Flatus vaginalis, 342 Fluid— in cvsts of broad ligament, 082 in ovarian cysts, (;64, 610, 617, 629 in uterine til)rocysts, 499 Fluids, antiseptic. 217 Foerster, table, 203 F(etas in fa-tu, 622 Folds, genital, 33 FoUet. vesico-uterine fistula, 395 FoliicU's— (Jraalian, 26 ])riniarv, 28 Folsoni-Skene, speculum, 154 Fomentation, 195 Food, 180, 240 Forcfp. — alligator, 647 artery-. 190 compared with ligatui-e, 515 cyst-. 646 dressing-, 152 hemo.-tatic, 190. 511 intra-utcrinf packing-, 185 pedicle-, 647 pressun;-, 190. 230, 511 tenaculum-, 228 tissue-, 228 tongur-. 223 tniction-. 228 trocar-, 702 Forcipressure. 190 used in hystfrcctomy, 511 ForcJLrn Ixxlji in ovary, ."iH"J in uterus. 422 in vagina, 362 Formalin cat;,'!!!, 214 Fornix of vai^ina, 42 Fossa— ischiorectal. 1 03 navicularis. 10 Foiirchctte, 37 (7 Fowler, pessary, 470 Franklinism, 246 Franzensbad, 196 Frenulum of clitoris, 38 Freund, hysterectomy, 549 operation for prolapse of uterus, 482 Fritsch, enucleation, 526 hysterectomy for prolapse, 482 operation for fecal fistula, 403 Frost, vaginal syringe, 709 Fry, electrode, 443 Fundus— of bladder, 80 of uterus, 48 Furrow, genital, 34 Fusion of ovarian cysts, 619 Gall-bladder torn in ovariotomy, 654 Galvanism, 247 Galvanocauterization — chemical, 250, 251, 507 for carcinoma of uterus. 546 for extirpation of uterus, 548 thermal, 252 Galvanochemical cauterization for ute- rine fibroid.s, 507 Galvanopunc-ture, 252 Ganglion, cervical, 65 Gangrene — of uterus, 452 of va<;ina, 372 of vulva, 289 Gariel, air-jtessary, 480 Garrigues', appai'utus for transfusion and infusion, 529 blunt ex))anding jierforator, 198 colpoperineorrhaphy, 327 diliitor. 157 headache jiowdcrs. 243 intra-uterine ap|)licatoi', 174 electrode. 249 packini^-forceps, curved, 185 strai-^djt, 185 tube. 177 j)erineal jiad. 324 scar! tier. I Hi serretiiies. ■■'.22 trachelorrhaphy needles, 418 weiiflit s))eculuili, 22') (lari-ulity ot" vnl\;i, 312 (Jarlner'^ canal. 20. ;!7S (ias arliliciallv develojx'd in stomach, 161 (ois-ether anesthesia. 220 (iauze ball-. 210 pads, I'lO .-|inne;es. 211 (iehi'iiii'.;. |iessary, 455 738 INDEX. Gelatinous disease of peritoneum, 021 Genital — cord, ;^1 cori)Uscles, 30 folds, 33 furrow, 34 tubercle, 33 Genitals — external, 35 internal, 35 Geode, 488 Genn-e]iitheliuni, 28 Germinal- spot, 74 vesicle, 74 Gestiition, incapacity for, 720 (iiraldez, organ of, 22 Glands — Bartholin's, 40 coccygeal, 105 Littre's, 79 manimarv, 116 pelvic, 62, 536 Skene's, 79 utricular, 51 vulvovaginal, 40, 308 GlanduliB vestibulares majores, 41 minores, 39 Glass plug for vagina, 354 Gloves for operating, 209 Glycerine tampon, 188 Glycerite of tannin, 188 Goelet, dilator, 158 ligation of uterine arteries for myoma, 509 Gold, 243 Goldan, inhaler, 221 Gonococcus, 364. 367 Gonorrhea, 133, 286, 287, 310, 366, 425, 558, 591, 695 danger of, 133 latent, 133, 718 Gordon, S. C, excision of cervix, 488 operation for chronic metritis, 438 Gossypii radicis cortex, 244 Graafian follicles — anatomy, 71, 72 development, 26 dropsy, 601 Gram's method of finding gonococcus, 864 Granular os, 428, 444 Greenlial<rh, metnjtome, 443 (Jymnastics. 200 (ivnecological treatment, cause of dis- ease, 133 Gyroma, 598 Hackdokn, needles, 280 Ilagedorn, needle-holder, 231 Hallucinations due to lacerated cervix, 416 Hanks, dilators, 157 Harris, M. L., separate collection of urine from the two kidnevs, 168 Headache powders, 243 Heart — artificial contraction, 220 examination in regard to operation, 205 Heat, 195 Heels, high, 130 Hegar, amytutation of cervical portion, 438 extra-abdominal treatment of pedicle in hysterectomy, 519 funnel-shaped excision of cervix, 447 operation for chronic metritis, 438 for complete laceration of perineum, 336 for pelvic abscess, 703 sacral hysterectomy, 549 Helicine arteries, 61 Hematocele, 631, 696, 698 of the canal of Nuck, 281 Hematocolpos, 345 Hematoma — of broad ligament, 631, 691 of ovary, 586 of round ligament, 282 of vagina, 361 of vulva, 295 pedendal, 283 Hematometra, 345, 408, 441 Hematosalpinx, 345, 554, 577 Hemorrhage — at climacteric, 128 from torn hymen, 860 from wound in vulva, 41 in hysterectomy, 529 in ovarian cysts, 619, 627 in perineal region, 110 int(!rnal, after ovariotomy, 667 intraperitoneal, 667 pelvic, 696 Hemostasis. 186 after ovariotomy, 664 Hemostatic— drutrs, 248 va«,Mnal ])lug. 183 Heredity, 129 Hermaphrodism, 276 Hermaphroditism, 276 Hernia — ant<'rior labial, 278 crural, of ovary. 582 in the canal of Nuck. 279 INDEX. 739 Hernia — inguinal, of ovary, 582 inguinolabial, 278 posterior labial, 279 umbilical, complicating ovarian cyst, 605 uteri, 418, 491 vaginal, 854 vaginolabial, 279 Herpes, progenitalis, 290 Hewitt, cradle pessary, 455 High-tension current, 247 Hilum, 08 Hodge, ])essary, 408 Hofineier, enucleation, 527 Horn of clitoris, 800 Horn-cells, (il2 Horns of uterus, 31 Horsehair, 210 Hottentot apron, 37 Hot water, 180 Hot-water l)ag, 195 Houston's valves, 90 Hunter, J. J3., needle, 514 Hvdatid— of liver, 084 of Morgagni, 30, 554 of pelvis, 715 Hydramnion, diagnosis from ovarian cyst, 082 " Hvdrobroiiiate nf hvoscine, 243 Hydrocele, 2H0 of ovary, 017 interi'iiitteiit. 554, 018 Hvdrolciiic. 270 Hvdrometra, 127. 411. 441, 032 Hydronaphthol, 218 Hydroii('pliro>is, 084 Hvdroj)s — ■folliculi, 001 tub;i' profiufiis, 554, 018 IIydn»rrheu. 480 gravidarum. 4;!0 put-rpcral. 480 Hydrosalpinx. 554, '■■ Hydrotherapy. 190 Hygroma, 844 Hymen — alinorma! opening al)>ent, 845 anatomy. 40 atresia, 845 bifenestratus. 847 bif-.ris, 847 cribriformis, ;M7 (level. i|iiiient. -V-', d..iit.le. :\\- fleshy. :!47 hemorrhai'e fn>m torn, 8tiO 5, 031, 035 in, 347 Hymen — malformations, 345 septus, 347 subseptus, 347 Hyperemia — of ovaries, 580 of pelvis, 129 Hyperesthesia of vulva, 294 Hyperplasia of vulva, 294, 304 Hypertrophy of uterus, 445 infravaginal, 445 supravaginal, 440 Hypnotics, 243 Hypodermoclysis, 226 Hypospadias, 273 Hysteralgia, 452 Hysterectomy, 510 abdominal, 451, 517, 549 compared with vaginal method, 524 American method, 519 causes of death, 529 extra-abdominal treatment of pedicle, 519 Faure's method, 508 for carcinoma uteri, 547 for hemorrhagic endometritis, 440 for prolapse, 482 for supravaginal hj'pertrophy of cer- vix. 451 for uterine libroid, 511 Freund's method, 549 Hegar's method, 549 intra-abdominal treatment of j)edi- cle, 518 mortality, 528 Pean's method, 510 perineovaginal, 550 Pratt's method, 517 retroperitoneal treatment of pedicle, 518 sacral, 549 Schroeder's method, 513 Schuchardt's method, 550 S))ecial difficulties, 522 su})ravaginiil am])Utation comiiared with total extirpation. 525 vaicinal, 451, 4H2, 511, 517. 710 C(im]iared witli abdominal, 524 vaLrino-abdomina], 517 with i^alvanocaiitery, 547 witii ligatures, 518, 547 with pressure-forceps. 511 witli therTnocauterv. 547 without ligature or foici'ps, 517 Hysteria, 20.') Hy>terocele. 491 Hysterocleisis. 897 Hysterocvstocleisis. 897 Hystero-epilejisy, 205 740 INDEX. Hystcr(>]>oxift, 473 al>cU>ininal, 474 vajjinal, 473 HYsterotrachelorrhaphy, 418 IcK-HAU, 19") Ichtliyol-<:;lyt'crine, 182 -lanolin, 17") Impotence, 718 Impregnation, artificial, 723 Incision — exploratory, 170, 630 of vaginal vault, 562 Incontinence of urine, operation for, 3.39, 398 Incubation, 311 Indurating edema of syphilis, 304 Induration, absent, 312 Inflammation, perimetric, 693 Infusion of salt solution, 529 Inhaler — Allis's, 222 Esmarch's, 222 Goldans, 221 Injections, 175 antiseptic, 176 astringent, 176 cleansing, 176 emollient, 176 hot-water. 187 hvpodermic, before operations, 206, 221 intestinal, for diagnosis, 161 intraperitoneal, 180 intra-uterine, 176 intravenous, 180, 220 iodine water, 702 rectal, 178 subcutaneous saline, 180, 529 vaginal, 175 vesical, 179 Injuries — of ])ody of uterus, 414 of cervix, 415 of intestine, 653 of perineum. 320 of uterus, 414 of vagina, 361 of vulva, 284 Insanity. 265 Inspection — of abdomen. 160 of trenitiils. 141 I]i.--trmiif'nt> — common. 226 disinfection of. 210 how to clean. 239 needed in all operations, 228 in ovariotomv, 642 Instruments — selection of, 239 Intermenstrual ])ain, 424 Intermittent hydrocele of ovary, 554, 618 Interpolar effect, 249 Intestinal — obstruction, 530, 628, 668 surgery, 724 Intestine — adherent to tvnnors, 517, 653 anastomosis, 724 button operation, 726 injury during ovariotomy, 653 invagination, 725 laid on abdominal wall, 565, 656, 665 resection, 724 Schroeder's method of repairing, 524 surgery, 724 Invagination theory, ()22 Inversion — instrumental replacement, 490 manual replacement, 490 of uterus, 485 of vagina, 360 operations for, 490 partial, 485 total, 485 Iodoform, 217 bougies, 426 gauze, 184, 185, 666 solution with tannin, 432 suppositories, 243, 324, 427 Iron contraindicated in uterine hemor- rhage, 245 pills, 242 Irrigation with hot antiseptic solution, 186, 239 Irrigator for bladder, 179 Irrital)le — bladder, 429, 433 vascular excrescence of the urethi'a, 300 Ischuria paradoxa, 636 Isthmus — of Fallopian tube, 65 of uterus. 49 Jacksion, speculum, 152 Jay, urinal, 398 Kaltkxbach, su])ravaginal amputation of cervix, 449 Kangaroo tendon, 216 Kasper, cystoscope, 166 Keith, opinion about Apnstoli's method. 508 Kelly, catheterization of ureter, 165 rubber cushions, 203 INDEX. 741 Kelh', spud for hysterectomy, 518 suspensio uteri, 474 vcntrotixatiun, 474 Kelsey, speculum, 152 Kemp, rectal tube, 17tt Keyes, irriijator, 179 Kidney — extirpation, G55 floating, •;o4 separate collection of urine from, 106 Kleptomania, 2(J5 Knives, 22i» uterine. 442 Knot, Staffordshire, 566 surgical, 233 Kocher, tissue-forceps, 228 Kieberle, artery clamp, 191 Kopnig, method of reviving, 220 Kraskc. hysterectomy, 549 Kraurosis vulvse, 307 Kreuznach, 196 Kucher)fneister, scissors, 442 Kiistner, Hajvoperalion for atresia. 3')0 operation for inversio uteri, 4'.»0 L.VHAKK.Mii'K, solution, 704 Labia majora — abnormal, 270 anatomy, 30 function, 37 Labia minora — anatomy, 37 function. 37 Labor, ovarian cyst during, 605 Laceration — of cervix. 415 of perineum. 320 compl.-t.'. 321. 325, 335 inconipl.-t.-, 321, 322. 320. 330, 338 inti'i-ni'-iiiate operation, 320 primary o])('ration, 322 secondary operation. 320 of vaginal entrance, 325 Lack of orgasm. 72:5 Laminaria. di>inffction of, 150 Lamp, clrctric, 055 I..aparotoniy. 043 compared with vaginal section, 524, 549, 570 for st.-niitv, 723 Late li..ur-.'l31 Laterol|e\i.,n. 113. 47S Latern|)o-ition. 113 Laterovi'r>ion, 4l:i. 47K Lauenstejn. suture. 33H Laxol, 311 I>ead and opium wa-h. 2h:! Li'avens, -lUure-,. I'l 1 Leech, artiticial. 194 Leeches, 194 Lefort's operation for prolapse of uterus, 481 Leggings, 207 Leg-hoider, 208 Leopold, apparatus for elevation of pel- vis. 141, 203 Leptothrix vaginalis, 309 Leucorrhea, 268 in jihthisis, 270 Ligaments — i)road, 57, 680 infundibulopelvic, 25, 65 interureteric. 83 of bladder. ^2 anterior false, 82 true, 82, 97 lateral false, 82 true, 82, 97 posterior false, 82 superi(^r false, 82 suspensorv, 82 true, .^2 ve?ico-uterine, 56, 82 of ovary, anatomy, 66 development, 23 of rectum, 98 of uterus, 55 perineal. 102 ])ubovesicai. 77. 97 round. 5'.t sacro-uterine. 50 sul>i.ubic. 102 superior round. 58 suspensory, of clitoris, 38 tran.-vei-se. of pelvis, 102 triangular, of urethra, 102 vesico-utei-ine. 50. S2 Ligamentum susj)ensorium of bladder, 82 Ligation of ])edicle of ovarian cyst, 047, 002. (Si'c Ligature. ) Ligature — -carrier. 233 chain-. 6i;2 <'oin])ared witli forceps, 515 ela>ti<'. 2:'.:!. 4'.iO. 51H for fec.MJ ti>t>ila. 402 in ovariotomv. 004 ma.-s-, ISS materi.'il. 233 method t'.ii- hvsterectomv, 513 of arteries. 1H7 of internal iliac artery, 5."><» pudic artery, ]s'.\ of utci-ine artei-y. l^s Lipoma — ■ of Kallo|)ian tube, 579 of vulva, 29'.) 742 INDEX. Lip? of cervical portion, 48 Liquor — ferri chloridi, 184 folliculi, 28, 74 Liver — adliesions, 655 floating, 034 Lotion to be used witli tincture of iodine, 197 Lotions — carbolic acid, 197, 290, 312 chloral hydrate, 288 hydrocyanic acid and lead, 288 Lubricant, 142 Lungs, examination in regard to opera- tions, 221 Lupus of vulva, 303 Lyjnjthadenitis, pelvic, 711 Lymphangitis, pelvic, 711 Lymphatics — of perineal region, 110 of uterus, 63 of vulva, 41 Lysol, 218 Malformations — of Fallopian tubes, 553 of hymen, 345 of ovaries, 581 of pelvic peritoneum, 679 of uterus, 40() of vatcina, 345, 347 of vulva, 273 Malignant tumor diagnosticated by can- cer cells in ascitic fluid, 541 Malposition of uterus, 413 Mammary gland, nonnal development simulating tumor, 116 for uterine fibroids, 507 of sheep in menorrhagia, 245 Manual replacement of inverted uterus, 490 Marcv. cobbler's stitch, 663 needle, 231 subcuticular suture, 650 ^larienbad, 197 Marriage — as a cure, 261 in relation to disease, 131 Marsupialization, 655, 660. 683 ^lartin, A., enucleation, 526 hysterectomy, 541 Martin, Franklin, ligature of uterine arteries for myoma uteri, 509 Massage. 199 for adhesions, 473 Masturbation, 316 ' Maunsell, artificial invagination of in- testine, 725 Mayer, pessary, 480 3Iayhem, 564 McXaughton, apparatus for elevated- pelvis position, 204 Meatus urinarius, 89 Medullary substance of ovary, 70 Membrana granulosa, 28, 72 Menopause, 125 treatment, 127 Menorrhagia, 263 Menses, 117 suppression of, 255 Menstrual — disorders, 265 period, 117 Menstruation, 117 abnormal, 255 coition during, 132 influence of operation, 121, 570 neglect during, 131 operations during, 201 precocious, 262 scanty, 258 supplementary, 258 tardv, 263 theory of, 122 vicarious, 258 Mensuration, 161 Mental aberration after ovariotomy, 671 Mercury, bichloride, 214, 545 Mesentery, adhesions, 625 of Miiilerian duct, 30 Mesoarium, 23 Mesorchium, 23 Mesorectum, 87 Mesosalpinx, 25, 67 Metastasis — from ovarian cysts, 620 from uterine cai'cinoma, 538, 540 Metbvl blue, 545 Metrftis, 423 acute, 423 chronic, 427 parenchymatous, 436 diphtheritic, 426 dissecting, 426 gonorrheal, 426 operations for, 438 parenchymatous, 423 Metrorrhagia, 265 Metrotome — Green halgh's, 443 Simpson's, 443 Migration of tumors, 498, 619 Mikulicz, abdominal tamponade, 186, 526 Milliamperemeter, 249 Miner, enucleation, 657 INDEX. 743 Mirror, concave, for throwins; light into abdominal cavity, 665 Mitchell, Hubbard, speculum, 149 Mitchell, S. "NV'eir, rest-cure, 241 Mixtures — A. C. E., 219 condurango, 545 hydrocyanic acid, 227 pepsin, 241 putash and belladonna. 287. 433 Schleich's, 218 strychnine, 242 Molecules moved bv electric current, 250 Molimina. 135, 141 Mons Veneris — anatomy, 35 function, 35 Monsel's solution — in enucleation of fibroid, 527 in ovariotomy, 665 .Monthlv— How, '117 sickness, 117 ;Murcellation, 505. 516 ^lorgagni, hydatid of, 30, 554 hicuna' of, 79 Morphine injected subcutaneously before anestiietizing, 221 Miillerian duct, 29 Munth', speculum. 149 Murphv, button, 726 MuM'ics— bulbocaverno.sus, 104 (•occyi;eu>. 99 com|)n'>sor urethnc. 10.5 constrictor urethne. 105 vagina', 106 deep transversus perinai, 106 dej)ressor urethra', 105 detrusor recti, 88 external sphincter uni, 88 (Jutliii.'s. 1(»6 intf-riial sphin<'ter ani, 88 iscliiocaverno.-us, 105 iscliiococcygeus, 99 Jarjavay s, 106 levator ani, 99 oliturat'icoccygeus, 99 jn-rinfal. 105 pubococcytci'ii-. 99 su]i('rti<'ial tr:iiisv<'r.-us perina-i, 106 tliini y^pliiiict<'r of n'ctum, 8K transversus urethra-. 106 Myotibroiiui — of utfTus. 494 of V!ii,'ina. 379. (See Fihroi'l, F'l- lir"»ni. l'"ihr<ii)itiuina, Mi/ditm. ) MyoniH — cavernous, of uterus, 494 Myoma — complicating ovarian cyst, 665 lymphangiectodes, 494 of uterus, 494 of vagina, 379 of vulva, 300 teleangiectodes, 494. (See Fibroid, Fibroma. ) Myomectomy, 527 Myosalpingitis productiva, 554 Myxoid cystoma, 605 Myxoma — of uterus, 492 of vulva, 300 Myxosarcoma — of ovary, 674 of uterus, 532 Nakoth, ovula of, 427, 430 Neck of womb, 47 Needles, 230 handled, 231 Hunter's, 514 Marcy's, 231 perineum, 437 Polk's, 519 Schroeder's, 519 Needle-holder — Crosbv's, 232 Hagedorn's, 231 Neglect of skin, 129 Negro, carcinoma, 537 uterine libroid. 5(K) Nelaton, artificial respiration, 220 cyst-forc<'ps, 646 Neoplasms — of P^illopian tube, 578 of ovary, (iOl of uterus, 492 of vagina, 378 of vulva, 29<) Nephritis caused bv anostlietics. 220, 530 Nerves — of perineal region, 110 of uterus. 65 Neuralgia — hunbo-abdominal, 431 of ut<'rus. 452 Neuroma of vulva, 300 NitroLclyccrin, 223 Noe<j;;erath. iiucrsion. 4!K) latent t;i>norrhea, 133 Nott, catlieter, 179 Nozzle witli stojK'ock. 209 Nubiiitv. 116 Nuck. canal of. :i7. 59. 281. 679 Nunn's i^orL;<'d coriuiscles. 611 Nussliaum, suj)rapuliic uretlira, 397 744 INDEX. Nyniplia> — anatomy, 87 progressive atrophy, 307 Obliquity of uterus, 414 Ooolusion dre.<siiii;. >V24 Okliuni albicans. 3t>U Ointments — chloral hydrate, '-'88 oonduraiii:;!). 044 Olshausen, ventrotixatioii, 474 Omentum adherent to tumors, 523, 655 Oophoralgia, G78 Oophorectomy — results of, 5ti9 Oophoritis, 590 acute, 5'Jl chronic, 593 follicular, 591 interfollicular, 591 transition to cyst, 594 Oozing tumor, 297 Opening, cloacal, 33 Operating-room, 202 Operating-table, 202 Boldfs, 203 Bozeman's 388 Cleveland's, 203 Foerster's, 203 Operations — after-treatment, 341 Alexander's, 471 assistants, 204 diet after. 239 disinfection, 209 during hot season, 201 during lactation, 202 during menstruation, 201 during pregnancy. 201 for incontinence, 359, 398 in general, 201 instruments which are used in nearly all. 227 preparation for. 202 of patient, 206 room, 202 rubber cushions, 203 spectators, 205 taljle for, 202 time of day for. 202 vessels needed in, 209 Opium — pills. 2til suppositorie-. 243 Organ of Giraldcs, 22 Organ. Kosenmiiller's, 22 Orgasm, 123 lack of, 723 Os— externum, 49 graiuilar, 428, 444 internum, 49 pinhole, 441 tinca>, 49 uteri, 49 Osmosis, electrical, 250 Ossilication — of corpus luteum, 595 of ovarian cysts, 620 Ostium — abdominale of Fallopian tube, 66 accessorv abdominal, of Fallopian tube, 553 uterinum of Fallopian tube, 66 Outerbridge, instrument for uterine dila- tation and drainage, 192 perineorrhaphy, 334 Ova- absence of, 719 anatomy, 74 development, 26 expulsion, 77, 119 formation, 26 primordial, 28 Ovarian — abscess, 591 cyst — adherent everywhere, 655 adhesions, 619. 653, 655 ascites, 628 blood corpuscles in fluid of. 610 calcification, 620 cancerous degeneration, 610. 620. 675 cholesterin in, 613 complicated with labor, 665 complications. 636, 665 congenital. (508 contents. 610, 617 cut oft' blood-supply from, 661 dermoid, 615 diagnostic value of examination of " fluid. 629 difi'erential diagnosis, 630 epithelial cells in fluid of, 611 etiology, 622 explorative — incision, 630 puncture. 629 extraperitoneal, 619 diagnosis, 636 fluid, 604, 610. 617. 629 fusion, 619 glandular, 606 hemorrhage. 619. 627 in mesentery, 658 inflammation, 627 intestinal obstruction caused bv, 628 INDEX. 745 Ovarian cyst — intraligamentous, 619, 656 irremovable, with colloidcontents,659 metastasis, 620 mixed proliferating, G15 multilocular, 608 myxoid, 605 origin, 621 originating in chronic oophoritis, 594 in corpus luteum, 594 ossification, 620 papillary, 614 parvilocular, (SIO part of, imbedded in pedicle, 657 pedicle, 618, 662 peritonitis caused by, 628 prognosis of, 637 proliferating, 605 pseudo-intniligainentous. 658 relation to carciiion.a, 610 retroperitoneal, 619 Rokitanski's. 604 rupture of, 620, 627 spindle-cells in fluid of, 618 suppuration of. 620, 627 symptoms of, 622 torsion of pedicle, 618, 627 treatment, 637 tubo-ovarian. 617 unilocular, 604 wall of, 604, 608, 616 with pregnancy, 637 tumor — intraligamentous, 619, 656 oligocvstic, 603 solid, 631, 671 (See Ovarian Cyst.) Ovaries — abscess, 591 absence, 581 ad<;no>arcoma. 674 alttiriiatf swelling at menstruatinn, 122 anatomy, 70 carcinoma, 675 carciiiomatDUs cystoma, 675 cirrli<>.--is, 591 cvstocarcinoiiia, 675 cvsts, (;06 d"<sc<-tit, 23 di"v<'lopiiicnt, 22 di-.-a-.-' nf, 581 di>j(la<-fm<'tit, 5K2 enilotl)<'lioma (Ackermann). 674 (.l<.ii.'<), 599 excessive growtli, 5H1 tibromu, 672 fibrosarcoma, 674 fon-igri l>odies, 5H2 function, 77 Ovaries — gyroma, 594 hematoma, 586 hernia, 582 hydrocele, 617 hyperemia, 586 inflammation, 590 intermittent hydrocele, 554, 618 ligament, 23, 70 malformations, 581 myxt)sarcoma, 674 neoplasms, 601 neuralgia, 678 palpation, 560 papilloma, 673 prola})se, 584 result of removal, 569 rudimentary, 581 sarcoma of, 674 carcinomatosum, 674 second ovary in ovariotomy, 649 supernumerary, 122, 581 transplantation, 571 tuberculosis, 677 with ))eduiiculated cysts, 605 Ovariotomy, 640 abdominal, 641 after-treatment, 651 causes <^f death after, 671 comjilications during after-treatment, 667 during oj)eration, 652, 665 contraindications, 640 difliculties. 652 drainage, 6f)5 hemostasis. 664 incomplete, 659 indications, 640 injury of gall-bladder, 654 of intestine, 653 of uterus, 65H instruments. 642 opiates. 651 papilloma extending into other organs, 659 }>ar<)titis after, fi71 pre])aratory treatment. 641 j)rognosis, 648 second ovary. 619 shock. 667 temjyerature. 668 toili't of jieritoiieum. 664 vaginal. <p41 Oviducts, r.'.t Ovi.sacs. 71 Ovula of Nabotb. 427. 430 Ovulation. 12(t Ovum. (See Oni.) Ox-gall, 178 ■4G INDEX. Pachydermia of vulva, 298 Pachyperitonitis, hemorrhagic, 687 Pachvsalpiugitis, 534 Pack; hot, IOC. Paokiiij::. vai^inal, 182 Pad, hypogastric. 200 perineal, 824 Pain, lotj intermenstrual, 437 Palnne plieata>, 49 Palpation — of abdomen, 160 of uretei-s, 166 Papilloma — growing from ovarian cyst into other organs, 659 in ovarian cyst, 614 of Fallopian tubes, 579 of ovary, 673 of uterus, 551 of vulva, 295 on outer surface of myxoid proliferat- ing cystoma of ovar\', 609 on outer surface of ovary, 615, 673 Paquelin's thermocauter}-, 187 Parametric connective tissue, 57 Parametritis, 693 Parametrium, 57 Parenchvmatous zone of ovary, 72 Paring, 229 Parotid gland in oophoralgia, 678 Parotitis after ovariotomy, 671 Parovarian varicocele, 680 Parovarium — anatomy, 77 development, 22 Partitioning the vagina, 481 Parturition — pelvic floor during, 113 results in regard to pelvic floor, 113 Patch, mucous, 314 Patient, preparation of, for operations, 205 Pawlik, operation for incontinence, 398 Pean, artery-clamp, 191 retractor, 512 traction-forceps, 228 vaginal hysterectomy, 709 Pectiniform septum. 38 Pedicle of ovarian cyst — com]iosition. 618 ligation, 647, 663 torsion, 618, 627 Pelvic — abscess, 701 hysterectomy for. 709 opening — in two sittings, 703 carcinoma, 714 Pelvic diaphragm — anatomy, 99 function, 99 floor — anatomy, 96 during parturition, 113 entire displaceable portion, 112 entire flxed portion, 112 function, 112 projection, 107 pubic segment, 112 results from parturition, 114 sacral segment, 112 sarcoma, 714 structural anatomy, 112 hematoma, 691 hemorrhage, 685 lymphadenitis, 712 lymphangitis, 712 peritonitis, 681 phlebitis, 711 sarcoma, 714 Pelvis — adhesions in, 654 diseases of, 679 hydatids, 715 malformations of, 679 three spaces of, 96 Penis captivus, 375 Pepsin, 241 Percussion, 160 Perimetric inflammation, 681 Perimetritis, 681 Perineal — body, 106 cystic hygroma, 344 hvsterectomv, 550 pkd, 324 region, 101 Perineorrhaphy — after-treatment, 341 Emmet's, 332 for retroflexion. 470 Garrigues', 328 intermediate, 326 Outerbridge's, 334 preparation for, 341 primary, 324 secondarv. 326 Tait's, 327 Perineum — complete laceration, 324 development, 31 diseases, 320 incomplete laceration, 322 injuries, 320 needle, 233 old lacerations, 327 recent lacerations, 320 INDEX. 747 Perioophoritis, 591 Perisalpingitis, 554 Peritoneum — function, 94 gelatinous disease, 621 pelvic, 92 pseudomyxoma, 621 taken for ovarian cyst-wall, 652 toilet, 664 Peritonitis — diagnosis from ovarian cyst, 630 pelvic, 681 septic. 669 with ovarian cyst, 628 Pessary — after ventrofixation, 469 Breisky's, 480 Emmet's, 469 Fowler's, 470 Gariels, 480 Geh rung's, 456 general remarks, 456 Hewitts cradle, 455 Hodge's, 469 Mayers, 480 retroflexion, 469 stem-, 461 Thomas's anteversion, 455 retroflexion, 586 vaginal, 455 Vienna, 455 , whalebone, 470 Petit s triangle. 7(»2 Petzer, catheter, 513 Phaijcdena, 311 I'liiintom tumor, 636 Phlebitis- after ovariotomy, 671 pelvic, 711 Phvsiologv. 116 Physometra, 127, 411. 441, 632 Pilimiction, 616 Pills— iilops and iron. 242 anti(ly.-iiif'ni)rrh(;ic, 261 C'bian turpi-ntiiM-, 544 coniuiii. 261 emmenagogue, J,-)i 'irihole os, 441 'inworms, 292 'latvsma, 58 'lf'(l'trct>. vaginal. 182 'liiM- palmatii-. 49 'iombi.'-ns. 196 'lug, vaginal, IH.-?. .'549 *oles, (|ualiti<'S <iC. "J.X) 'olvpus— fibrinous. 493 fibroid uterine. 494 Polypus — fibroid vaginal, 380 glandular. 492 hollow, 488, 491 intermittent, 499 mucous, of uterus, 427, 492 vaginal, 381 myxomatous, 492 Position, 138 breech-back, 139, 208, 388 dorsal, 138 elevated-pelvis, 140, 223 erect, 140 genupectoral, 140 high pelvic. (See Elcmfed pelvis.) Simon's, 208, 388 Sims's, 139 ventral, 141 Posterior commissure, 36 Postural treatuient of retroflexion, 470 Potain, as])irator, 170 Potassa, 287, 433 Pouch — Hrocas, 37 Douglas's, 93 oliturator, 93 para-uterine, 93 paravesical, 93 recto-abdominal, 93 recto-uterine, 93 utero-abdominal, 93 vesico-abdominal, 93 vesico-uterine, 93 Poultice, 195 Powders — headache, 267 phenacetine compound, 267 Pozx.i — injury to ureters, 655 operation for urethrovaginal fistula, 394 Pratt, hysterectomy, 517 Preoicity. 406 Pregnancy — diagnosis from ovjirian cyst, 623 in relation to uterine fibn^ids, 527 o])('rations during, 201 with cancerous uterus, 548 with ovarian cyst, 637 Pregnant cancerous uterus removed by vaginal hysterectomy, 548 Prenuce. 87 adherent, 275 Press) ire — as hemostatic, 663 -fonej)s. 190. 230, 511 symptoms, ')<K) Priessnit/'s cotnpn'ss, 195 Primary follicles, 2H 748 INDEX. Primordial ova, 28 Probe, 155 Procidentia of uterus, 470 Proiiressive atrophy of nyinphap, 307 Prolapse — acute, of uterus. 470 artificial, of uterus, 145 Brandt's nietiiod, 480 chronic, 471* complete, 470 incomplete, 469 Lefort's operation, 481 of anterior wall of vagina, 356 of intestine into deep Douglas's pouch, 355 of ovaries, 584 of p()sterior wall of vagina, 359 of urethra, 315 of uterus, 470 of vagina, 360 operations, 481 Prolapsus of uterus, 470 Proliferating cyst, G05 Pruritus, 291 l*ryor, hysterectomy, 519 Pseudohermaphrodism, 277 Pseudo-intraligamentous tumors, 659 Pseudomvxoma of peritoneum, 621 Puberty, "116 dilferent from nubility, 116 Puncture, explorative, 629 Puncturer, expanding, 198 Pus, inspissation of, 574 Pvocolpos, 345 "lateral, 353 Pvometra, 345, 411, 441 Pyosalpinx, 554, 574, 631 saccata, 554 Pyromania, 265 Raphe — ano-coccygeal, 99 perineal, I03 Pieceptaculum seminis, 67 Keftal— alimentation, 241 ampulla, 87 speculum. 153 Pvect(jcele, 359 Emmet's operation, 332 Rectum — anatomy, 86 functi<^n, 91 Reese, artitieial leech, 194 Regicjns — abdominal, 115 anal, 101 perineal, 101 urogenital, 101 Relaxation of abdominal wall, 652 Repositor — Aveling's, 489 Bvrne's, 490 White's, 490 for inversion, 489 for retroflexion, 469 Resolution, 243 Resolvents, 243 Respiration, artificial, 221 Rest-cure, 242 Retractor — Engelmann's 227 Landauer's, 646 muscles of uterus, 56 Pean's, 512 Schroeder's, 227 vaginal, 227, 512 Retroflexed gravid uterus, 631 Retroflexion, 465 Retro-ovarian shelf, 93 Retroposition, 413 Retroversion, 464 Reverdin, apparatus for lifting large tumors, 523 Reviving from anesthesia, 209. 223 Rheophores, 249 Rheostat, 249 Richardson's bellows, 221 Rima pudendi, 36, 43 Robb, leg-holder, 209 Rodent ulcer, 536 different from the corroding ulcer, 541 Rokitanski's tumor, 604 Roof of vagina, 42 Room, operating-, 202 Rose, H., separate collection of urine from kidneys, 166 vesical speculum, 167 Rosenmuller's organ, 22 Round ligament — anatomy, 59 diseases, 684 fibroma, 283 function, 51, 62 hematoma, 282 shortening, 471, 478 tumors connected with extrapelvic portion, 280 Rubber — - bag for injecting bladder, 180 cushions for o]ierations — Kellv's, 203 Marcy's 203 ligatures, preservation of, 221 Rudimentary horn of uterus, 4(»H Ruga; of vagina, 43 Rupture of ovarian cyst, 620, 627 Ruptures (hernite), 278 INDEX. 749 Sacral hysterectomy, 549 Sacro-uterine ligament, 56 diseases of, 684 Salpingitis, 554 acute catarrhal, 554 purulent, 554 chronic interstitial, 554 conservative treatment of, 563 cystic, 554, 572 infectious, 554 interstitial, 555 isthniica nodosa, 554 munil, 5->4 non-inffctious, 554 parenchymatous, 554 profluont, 554 Salpingo-iiopliorectomy, 563 abdominal, 564 for aiitetiexioii, 464 for hemorrhagic endometritis, 440 mortality, 568 results, 56!t vaginal, 570 with ventroHxation, 478 Salt, solution of. 529 Sand-bodies, 615 Sarcoma — carcinomatosum of ovary, 674 decidual, 5:^4 of Fallopian tube, 579 of ovarv. 674 of pelvis, 714 of uterus, 531 of vagina, 594 of vulva, 302 Scarification of vaginal [)ortion, 195 Scariticatur, Garrigues', 195 Scliede. operatioi> for un-terovaginal fis- tula. .".'.(4 Scliimmi'Ibu.-th. sterilizatioii-box, 212 Scbl.-iclrs anc-tlictic. 218 Scliroedcr, ni'i-djc for hysterectomy, 519 operation for vaginal cyst, .'!79 repair of iiite.-tiric. 524 vaginal retiactor, 227 Scbuchardt, hy.-terectomy, 549 Scliult/.e. disinfection of lumiMaria tents, 15*; nietliod of tearing adhesions of ovarv, 5h.'. of uterus. 47:' Scirrhus of vulva. :'02 Sciv-ors, 22'.» Mozeiiian'> 505 Kucbeiuiiei'ter's. 442 .•-^i;! relief, ureteral, 165 .■^eciiiiii, \ airiiial. compan-d with abdomi- nal. 524. 572 Sedativev 21:; Segmental vesicles, 21 Segond, speculum, 511 vaginal hysterectomy, 510 Septicemia, 530, 669 Septum — pectiniform, 38 retrohymenale, 347 transverse perineal, 103 Serrefines, 322 Shelf, retro-ovarian, 94 Shock, 528, 667 Shortening of round ligament — extraperitoneal, 471 intraperitoneal, 471 vaginal, 476 Shouldering, 235 Silk, 212 Silkworm gut, 216 Silver wire, 216, 233 Simon, cone-mantle-shaped excision of cervical portion, 439 curette, 155 operati()n for fistula, 388 position, 208, 388 Simpson, J. Y., metrotome, 442 Sims, Marion, catheter, 387 discission of posterior lip of cervix, 461 operation for anteversion, 457 for cystocele, 357 for rectovaginal fistula, 386 for urinary fistula, 386 speculum, 147 sponge-holder, 229 suture-shield, 234 uterine knife, 442 Sinus cojjularis. 30 urogenital, 20, 31 Sinuses of ^lorgagni, 90 Skene's glands, 80 Smith, cautery-clamp, 648 Snegiretf, vaporization, 186, 654 Sodium suljihate, 245 Solution — horosalicylic, 218 ergotine, 507 Labarraquc's, 704 Monsel's, 527, 665 normal salt, 529 sclerotinic acid, 50*) sodium carbomite, 210 tnnnin-iodoform, 432 Tliierscii's, 21 K Villates, 70 J Solutions, antiseptic. 217 Soullle, uterine. Ifil Sound, uterine. 1 51 Space — .-ui>cutan«-<ius, of jichis, 96 750 INDEX. Space — subperitoneal, of pelvis, 96 Spanish-fly blister, 197 Spectators, 205 Speculum — Ashton's, 153 bath-. 195 bivalve, 147 bladder-, 165 Bozonian's, 388 Brewer's, 147 Burrage's, 152 cervical, 152 Cusco's, 152 Ehrich's, 151 Fergusson's, 146 Folsom-Skene's, 154 Garrigues', 226 Jackson's, 153 Kelly's, 165 Kelsev's, 153 Mitchell's, 150 Munde's, 150 plurivalve, 146 rectal, 153 Segond's, 511 self-holding, 150 Sims's, 147 tubuliform, 146 univalve, 147 urethral, 153 vaginal, 146 Sphincter — ani, how to unite broken, 339 muscles of urethra, 79 of rectum, third, 88 Spina biflda, 635 Spiritus glonoini, 223 Spleen — adhesions, 654 cyst, 635 tumor, 635 Sponge-holder, 228 Sponge taken for carcinoma, 538 S{)(jnges, 211 Sponging, 238 Spongiopiline, 196 Spontaneous opening of wound ovariotomy, 669 Spoon, shai'j), 155 Spoon-saw, 505 Si)rings, mineral, 196 StatIV)rd.>hire knot, 566 Stt'airi as disinfectant, 209 as hemostatic, 654 Stearate of zinc. 667 Stem-pessary, 455 Stenosis — of cervical canal, 259. 394. 421 after Stenosis — of cervical canal, acquired, 421 congenital, 421 of vagina, 347 Sterility, 718 after double ovariotomy, 671 in the female, 719 in the male, 718 primary, 719 secondary, 719 Sterilization — of catgut, 212 of water, 216 Sterilizer, 209, 212 Arnold's, 211 Schimmelbusch's, 212 Stimulants, 223, 240 Stitch, cobblers', 649, 662 Stomach, dilatation of, 635 Stramonium pills, 260 Structureless membrane of Graafian fol- licle, 69 Strychnine — in collapse, 223 mixture, 243 pills, 257 Stupe, 195 Styptics, 186 Subinvolution of uterus, 436 menstrual, 263 Summit of bladder, 78 Superfetation, 410 Superinvolution of uterus, 451 Supporter — abdominal. 199 uterine, 480 Suppositories — with iodoform, 343, 407 with morphine, 343 with opium, 243 Suppuration of ovarian cyst, 620 Supravaginal amputation compared with total extirpation of uterus, 525 Suspen.sio uteri, 474 Suture, 233 buried catgut, 329, 331 button-, 368 chain-, 238, 660 cobblers' stitch, 649, 662 continuous, 236 Czerny-Lembert's, 653 for fecal fistula, 402 for hemostasis, 191 for inversion, 490 for urinary fistula, 365 forming nucleus of stone, 391 glovers^'. 238 Halsted's, 650 horsehair, 214 INDEX. 751 Suture, how to remove, 238 interrupted, 236 kangaroo tendon, 216 Lauenstein's, 388 looped, 238 Marovs, 650 material, 210, 233, 322 mattress-, 191 quilled, 191, 236 removal of, 238 running, 236 secondary infection of, 233 -shield, 235 shouldering, 235 silk. 211, 233 silkworm gut, 216 silver wire, 216, 234 sterile, 210 subcuticular, 650 suhmucous, 338 tier-, 237 twisting, 236 Swedish movement cure, 200 Svlvester's artificial respiration, 221 Syphilis, 312 indurating edema, 304 initial lesion, 312 secondary, 314 tertiary, 315 Syringe — Braun's, 176 bulb-and-valve, 175 Davidson's, 175 exploratorv vaginal, 169 for bladder, 179, 180 fountain, 175 Fritsch's, 288 Frost's, 709 uterine, 176 Tahlk— Daggett's, 137 examining-, 137 '){)erating-. (See Operatinfj-tahle.) Tait, llap-splitting operation for j)erineal laceration, 327 operation for f<!cal fistula, 403, 404 for urinary fistula, 3H9 sujpini^o-oopborectomy, 564 sliort<iiing of round ligaments, 476 "Tail's operation," 564 Tampon — abdominal. 186 vaginal. IK'J Tamponade, I Hi of Uterus, 1H5 Tannin — U'lycerite, 1H2 solution with iodoform. 432 Tape-carrier, 504 Tapping, 197, 638 Tate, inversion, 502 Taylor, I. E., operation for rectolabial fistula, 402 Temperature after ovariotomy, 668 Tenaculum, 228 Emmet's, 228 Tenaculum-forceps, 228 Tendinous arch, 96 Tent-carrier, 157 Tents, 156 Terraline, 270 Tetaims, 530, 671 Thermal galvanocauterization for cancer of uterus, 546, 547 Thermocauterectomy of uterus, 547 Thermocautery, 187 Thiersch's solution, 218 Thirst, 239 Thomas, antevei-sion j)essary, 4')5 cla.ssitication of antetlexion, 458 curette, 155 enucleation of uterine fibroids, 508 invei-sion, 489, 490 operation for vaginismus, 377 retroflexion pessary, 586 spoon-saw, 505 stem-pessary, 461 Thompson, bladder-syringe, 180 Thrombosis, 530 Thrombus — of vagina, 361 of vulva, 295 Thymol, 218 Thyroid, relation to uterus. 412 Tincture of iodine — in ovariotomy, 665 in ])elvic abscess, 702 in the vagina. 175 on the skin, 196 Tissue-forceps, 229 Toilet of jH'i'itoneum, 664 Tongue-force})s, 222 Tonics. 242 Torsion of pedicle, 618, 627 Trachel()rrbai>hy, 41H for retrollexion, 470 needles, 418 Traclielotomy. 442 Traction, for removing uterine (iliroids. Transfusion. 529 Transpliintation of ovary. oTO of vaLrinal l]aj)s, 353 Travelling, cure for sterility, 722 Trejilmeiit — electri.-. 246 external. 174 752 INDEX. Treatment — in general, 172 internal, 240 preventive, 172 Trendelenburg, operation for fistula, 389 position. (See Elevated Pelvis. ) anesthesia in, 222 Trithiasis, 2!ll Trichomonas vaginalis, 364 Trigone, Lieutaud"s, 81 Tripperfaden, uOO Trocar — Emmet's, (546 vaginal, 197 Warren's, 639 Tubercle, genital, 33 of vagina, 43 Tuberculosis — of Fallopian tube, 579 of ovary, 677 of peritoneum, 633 of uterus, 551 of vagina, 382 of vulva, 306 Tubes— double-current uterine, 178 drainage-, 193 Fallopmn, 66, 580 dilated, 177 rectal, 179 single-current uterine, 177 Tubo-ovarian cj'st, 617 Tumeur fluxionnaire, 437 Tumor — fibroid, of uterus, 493 loose, 498, 619 migrant, 498, 619 of abdominal wall, 635 of broad ligament, 684 of round ligament, 280 of spleen, 635 of vulva, 294 (See Cancer, Carcinoma, Cyst, Fi- broid, Sarcoma. ) oligocystic, 603 oozing, 297 painful, of urethra, 300 phantom, 636 Kokitanski's, 604 solid o\ariaii, (;71 vascular, of urethra, 300 Tunica — fibrosa of Graafian follicle, 73 propria of Graafian follicle, 73 Turns, 117 Turpentine, Chian. 545 Tuttlf. fibroma moUuscum, 299 Tympanites, 178, 636, 667 Ulcer — corroding, 444, 540 of cervix, 444 rodent, 53<) simple, 444 tuberculous, 306, 382, 444 venereal, 310, 312 TJnguentum Crede, 175 Urachus, 31, 83 persistent, 517, 652 Ureter — anastomosis, 655 anatomy, 84 at base of intraligamentous tumors, 659 catheterization, 165 course during pregnancy, 85 examination, 162 function, 86 implantation, 395 injury, 391. 393, 537, 655 ligation, 391, 530, 537 opening into vagina, 354 palpation, 166 Ureterocystostomy, 395 Urethra — anatomy, 79 atresia, 392 caruncle, 300 dilatation of, 144 ducts, 80 inflammation of, 289 function, 81 irritable vascular excrescence, 300 painful tumor, 300 prolapse, 315 suprapubic, 397 vascular tumor, 300 Urethral — ducts, 80 inflammation of, 289 speculum, 152 Urinals, 397 Bozeman's, 398 Jay's, 398 Urinary analysis, 161 Urine — alkaline, 375 collected separately from kidneys, 168 examination with regard to opera- tions, 205 suppression of, 668 Urogenital region, 99 sinus, 20, 31 persistent, 354 Uterine appendages of the other side — in ovariotomy, 648 when one set is removed, 567 artery — aiieurvsm, 679 INDEX. 763 Uterine artery — during pregnancy, 62 ligature of, 188 cancer, 530 radical treatment, 545 carcinoma, 536 fibrocyst, 499 treatment, 530 fibroid — aMominal enucleation, 521 apparatus for lifting, 523 cervical, 494 changes, 499 combined with pregnancy, 527 corporeal, 494 curetting, 508 galvanochemical cauterization, 507 hypodermic injection of ergot, 507 indications for operations, 531 in negro race, iyOO interstitial, 496 • intramural, 496 mortality of operations, 528 multiple, 498 pedunculated, 496 sessile, 496 single. 498 sloughing, 528 submucous, 496 subperitoneal, 496 supravaginal amputation, 523 traction method, 509 vaginal enucleation, 508. (See I'fn-iis. ) Uterotract^tr, 547 terus — absence, 406 acollis, 413 actjuircd atrophy, 451 adenoma, 492 anatomv, 4H untcficxion, 413, 458 ariteposition, 413 antcvcrsion, 453 apoplexy, 127 arrest of devflopment, 406 artificial prolapse, 145 atresia, 410, 440 atropliy, 451 bicariiiTiitiis vctiilarum, 127 bicoriiis. 409 liiloculiiris, 409 bimanual rej)lacernent, 468 body, 48 cancer, 531 carcinDniH, 536 of body, 537 of cervix, 537 48 Uterus — carcinoma of vaginal portion, 536 catarrh, 430 cavernous angioma, 494 cavity, 50 cervical carcinoma, 536 cervix, 48 closure, 440 congenitally atrophic, 412 corpus, 48 cystosarcoma, 532 cysts, 493 descent, 478 development, 31 excessive, 405 didelphys, 407 digital replacement, 469 dilatation, 158 diseases, 406 displacement, 453 duplex separatus, 407 elevation, 485 enchondroma, 551 erosions, 427, 433, 444, 542 excessive development, 406 extirpation, 510 fetal, 411 fibrocysts, 499, 632 fibroid, 494 tumor, 494 fibroma, 494 fibromyoma, 494 foreign bodies, 422 function, 65 fundus, 48 fangrene, 452 ernia, 413, 491 horns, 31 hypertrophy, 445 imperforate, 410 infantile, 411 inflammation, 423 injuries, 414 inversion, 485 irregular development, 413 isthmus, 50 lateroflexion, 413, 478 lateroposition, 413 lateroversion, 413, 478 ligaments, 56 lips, 49 male, 30 malformations, 406 maliiosition, 413 niucnus membrane, 51 myofibroma, 4!t4 myoma, 494 inyxoma, 492 myxosarcoma, 532 1 54 INDEX. Uterus — nec-k, 48 neoplasms, 492 neuralgia, 452 ohlicjuity, 414 pa})ill()nia, ool parvicollis, 418 perforation, 181 jwlypus, 41»2 clandular, 492 hollow, 488, 491 mucous, 492 niyxoinat<jus, 492 position, o'2 procidentia, 478 prolapse, 478 prolapsus, 478 pubescent, 412 relation to thyroid, 412 repositors, 4(J9 retractor muscles, 56 retroflexion, 465 retroposition, 413 retroversion, 464 rudimentary, 407 horn, 408 sarcoma, 531 senile atrophj', 451 septus. 409 severance of adhesions, 475 shape and position, 52 subinvolution, 436 subse))tus, 409 superinvolution, 451 supravaginal amputation, 517. (See Hystey^ectorny. ) suspension, 474 tamponade, 186 thermocauterectomv, 547 total extirpation, 510 compared with supravaginal am- putation, 525 tuberculosis, 551 tumeur fluxionnaire, 437 unicornis, 408 vaginal portion, 48 vaginofixation, 472 ventrofixation, 474 wounded in ovariotomy, 655, 658 Vagin'a — anatomv, 41 atresia, '348, 854 blind canals, 854 carcinoma, 881 cicatrices, 378 columns, anterior and posterior, 48 cysts, 378 development, 31 Vagina — diseases, 845 double, 858 entrance, 43 erysipelas, 873 extirpation, partial or total, in carci- noma of uterus, 547 faulty communications, 354 fibroid polypus, 379 tumor, 379 fibroma, 379 fibromyoma, 379 foreign bodies, 362 function, 46 gangrene, 872 glass plug, 349 hematoma, 362 how to keep open after atresia opera- tion, 349, 350 incision, 472, 511, 514, 562, 702 injuries, 361 inversion, -360 laceration of entrance, 325 malformations, 345, 347 mucous polypus, 381 myofibroma, 379 narrowness, 348 neoplasms, 378 partitioning, 481 prolapse, 360 of anterior wall, 356 of posterior wall, 360 roof, 42 ruga?, 43 sarcoma, 381 stenosis, 847 tamponade, 184 thrombus, 361 tubercle, 43 tuberculosis, 382 Vaginal — enterocele, 354 case of, 355 glass plug, 192 hernia, 854 hysterectomy, limits, 517 portion — anatomy, 48 development, 32 subinvolution, 486 speculum, 146 Vaginismus, 347, 375 deep, 875 superficial, 375 Vaginitis, 868 acute, 363 adhesive, 364 catarrhal, 864 chronic, 863 INDEX. 755 Vaginitis, diagnosis between simple and gonorrheal, 866 diphtheritic, 870 dissecting, 371 due to burrowing pus from pelvic ab- scess, 872 dysenteric, 871 emphysematous, 869 epithelial, 368 exfoliative, 368 exudative, 850 follicular, 364 glandular, 364 gonorrheal, 366 gniTiular, 364 mycotic, 361* phlegmonous, 371 primary, 363 secondary, 368 simple, 364 Vaginofixation of retroflexed uterus, 478 Valves — Houston's, 90 of rectum, 90 Van Hook, ureteral anastomosis, 656 Vaporization, 511 Varicocele — of broad ligament, 680 parovarian, 680 Vascular zone of ovary, 71 Vegetations of vulva, 296 Veins — of ])erineal region, 110 uterine, 61 varicose, of vulva, 295 Venereal diseases, 310 Ventrofixation of uterus, 474 Becks metliod, 475 Kelly's, 474 Olshausen's, 474 Vesicles, segmental, 21 Vesicula prostatica, 30 Vessels needed for operations, 208 Vestibule — anat<jmy, 39 development, 32 function, 4(» A'estilmiovagiiiiil l)ulk, 39 Vignard, operation fur fecal fistula, 403 Villate, solution, 704 Viiieberg, vaginal fixation, 475 \'irgins, examination of, 159 ^'itellin(! membrane, 74 Vitellus 74 Volseila. 22K Vomiting, 201, 227, 242, 243, 667 Vuillet, method of dilatation, 159 Vulva — absence, 273 Vulva — anatomy, 36 angioma, 300 atrophic carcinoma, 302 cancer, 302 carcinoma, 302 chronic infiltration, 303 inflammation, 303 ulceration, 303 cysts, 301 development, 33 diseases, 273 elephantiasis, 298 epithelial coalescence, 276 epithelioma, 302 exanthematous diseases, 290 fibroma, 299 gangrene, 289 garrulity, 842 hematoma, 295 hvperesthesia, 294 hyperplasia, 294, 304 injuries, 283 kraurosis, 307 lipoma, 299 lupus, 803 malformations, 273 medullary carcinoma. 302 mclanosarcoma, 302 myoma, 299 myxoma, 299 ne()j)lasms, 29() neuroma, 30:i oozing tumor, 297 pachydermia, 298 pa))illoma. 296 pi-uritus, 291 sarcoma, ;!()2 scirrlius, ;)()2 thrombus, 295 tuberculosis. 30*1 tumors, 294 varicose veins. 295 vegetations, 2'.t'i warts. 295 Vulvitis, 285 Vulvovaginal inland — abscess. 3(t'.i anatomv. 10 ciitarrh! :!(tx cvsts, 30S diseases, 30S Vulvovai:initi> in eliildren. 372 Wai.ciikk. operation for listula, 3iK) Walii<'h, cliaiM-snture, 662 Warren, tioi-ar, <i3'.i \Vart> of vulva. 2'.t5 756 INDEX. "Water — hot, 18G sterilized, 218 "Watkins, operation for cystocele, 358 Wells, pedicle-forceps, 647 White line — at anus, 89 of labia minora, 37 Whites, 268 Wiley, Gill, shortening of round liga- ments, 476 Wire-twister, 235 Wolffian— body, 20 duct, 19 Woman's dartos, 37 Womb, falling of, 478 Xenomenia, 258 Zona pellucida, 74 CATALOGUE OF THE MEDICAL PUBLICATIONS OF W. B. SAUNDERS & CO., No. 925 WALNUT STREET, PHILADELPHIA. Arranged Alphabetically and Classified under Subjects. THE books advertised in this Catalogue as being sold by subscription are usually to be obtained from travelling solicitors, but they will be sent direct from the office of pub- lication (charges»of shipment prepaid) upon receipt of the prices given. All the other books advertised are commonly for sale by booksellers in all parts of the United States; but books will be sent to any address, carriage prepaid, on receipt of the published price. Money may be sent at the risk of the publisher in either of the following ways : A post- office money order, an express money order, a hank check, and in a regisiereil letter. Money sent in any other way is at the risk of the sender. See p<^es 32, 33 for a L'^t of Contents classified according to subjects* LATEST PUBLICATIONS. American Students* Medical Dictionary, See page 34. American Text-Book of Physiology — Second (Revised) Ed. Page?. Friedrich and Curtis on Nose, Throat, and Ear. See page 34. Le Roy's Histology. See page 34. Ogden on the Urine. See page 34. Pyle's Personal Hygiene. See page 34. Salinger and Kalteyer's Modern Medicine. See page 34. Stoney's Surgical Technic for Nurses. See page 34. Hyde and Montgomery's Syphilis and Venereal Diseases — Revised and Enlarged Edition. See page 15. International Text-Book of Surgery. See page 15. Garrigues* Diseases of Women — Third (Revised) Edition. Page 13. American Text-Book of Dis. of Eye, Ear, Nose, and Throat. Page 5. Saunders' American Year-Book for 1 900. See page 8. Levy and Klemperer's Clinical Bacteriology, iee i-age 17. Scudder's Treatment of Fractures. See page 26. Senn's Tumors — Second Edition. See page 27. Beck on Fractures. See page 9. Watson's Handbook for Nurses. See page 31. Heisler's Embryology. See page 15. Nancrede's Principles of Surgery. See page 20. Jackson's Diseases of the Eye. See page J6. Kyle on the Nose and Throat. See page 17. Penrose's Diseases of Women — Third (Revised ' Edition. Page 20. Warren's Surgical Pathology— Second ' Revised) Edition. Page 31. Saunder's Medical Hand-Atlases. Sec pages 2, 3, 4. American Pocket Medical Dictionary — Third (Revised) Ed. Page 12. SAUNDERS' MEDICAL HAND-ATLASES. The series of books included under this title consists of authorized translations into English of the world-famous Lehmann Medicinische Handatlanten, which for scientific accuracy, pictorial beauty, com- pactness, and cheapness surpass any similar volumes ever published. Each volume contains from 50 to 100 colored plates, executed by the most skilful German lithographers, besides numerous illustrations in the text. There is a full and appropriate description of' each plate, and each book contains a condensed but adequate outline of the subject to which it is devoted. One of the most valuable features of these atlases is that they offer a ready and satisfactory substitute for clinical observation. To those unable to attend important clinics these books will be absolutely indis- pensable. In planning this series of books arrangements were made with the rep- resentative publishers in the chief medical centers of the world for the publication of translations of the atlases into different languages, the litho- grai)hic plates for all these editions being made in (Germany, where work of this kind has been brought to the greatest perfection. The expense of making the plates being shared by the various publishers, the cost to each one was materially reduced. Thus by reason of their universal transla- tion and reproduction, the publishers have been enabled to secure for these atlases the best artistic and professional talent, to produce them in the most elegant style, and yet to offer them at a price heretofore unap- proached in cheapness. The success of the undertaking is demonstrated by the fact that the volumes have already appeared in thirteen different langnages— German, English, French, Italian, Russian, Spanish, Japanese, Dutch, Danish, Swedish, Roumanian, Bohemian, and Hungarian. In view of the striking success of these works, Mr. Saunders has con- tracted with the ])ublisher of the original German edition for one hun- dred thousand copies of the atlases. In consideration of this enormous undertaking, the iniblisher has been enabled to prepare and furnish special additional colored j^lates, making the series even handsomer and more complete than was originally intended. As an indication of the practical value of the atlases and of the favor with which they have been received, it should be noted that the Medical Department of the U.S. Army has adopted the "Atlas of Operative Surgery" as its standard, and has ordered the book in large quantities for distribution to the various regiments and army posts. The same careful and competent editorial supervision has been secured in the English edition as in the originals, the translations being edited by the leading American specialists in the different subjects. SAUNDERS^ MEDICAL HAND-ATLASES. VOLUMES NOW READY. Atlas and Epitome of Internal Medicine and Clinical Diagnosis. By Dr. Chr. Jakob, of Erlangen. Edited by Augustus A. Eshner, M.D., Professor of Clinical Medicine, Philadelphia Polyclinic. With 68 colored plates, 64 text-illustrations, and 259 pages of text. Cloth, $3.00 net. " The charm of the book is its clearness, conciseness, and the accuracy and beauty of its illustrations. It deals with facts. It vividly illustrates those facts. It is a scientific work put together for ready reference." — Brooklyti Medical Journal. Atlas of Legal Medicine. By Dr. E. R. von Hofm.anx, of Vienna. Edited by Frederick. Peterson, M.D., Chief of Clinic, Nervous Dept., College of Physicians and Surgeons, New York. With 120 colored figures on 56 plates, and 193 beautiful half-tone illustrations. Cloth, $3.50 net. " Hofinann's 'Atlas of Legal Medicine ' is a unique work. This immense field finds in this book a pictorial presentation that far excels anything with which we are familiar in any other work." — Philadelphia Medical Journal. Atlas and Epitome of Diseases of the Larynx. By Dr. L. Grunwald, of Munich. Edited by Charles P. Gravson, M.I)., Physician-in-Charge, Throat and Nose Department, Hospital of the University of Pennsylvania. With 107 colored figures on 44 plates, 2^ text-illustrations, and 103 pages of text. Cloth, $2.50 net. "Aided as it is by magnificently executed illustrations in color, it cannot fail of being of the greatest advantage to students, general practitioners, and expert laryngologists." — St. Louis Aledical and Surgical Journal. Atlas and Epitome of Operative Surgery. By Dr. O. Zuckerkandl, of Vienna. Edited by J. Chalmers DaCosta, M. D., Professor of Practice of Surgery and Clinical Surgery, Jefferson Medical College, Philadelphia. With 24 colored plates, 217 text-illustrations, and 395 pages of text. Cloth, $3.00 net. " We know of no other work that combines such a wealth of beautiful illustrations with clearness and conciseness of language, that is so entirely abreast of the latest achievements, and so useful both for the beginner and for one who wislies to increase his knowledge of operative surgery." — Munchener mcdicinisclie Wochenschrift. Atlas and Epitome of Syphilis and the Venereal Diseases. By Prof. Dr. Franz Mracek, of Vienna. Edited by L. Bolion Ban<;s, M.D., Professor of Genito-Urinary Surgery, University and liellevue Hospital Medical College, xN'ew York. \\'ith 71 colored plates, 16 black-and- white illustrations, and 122 pages of text. Cloth, $3.50 net. '• A glance through the book is almost like actual attentiance upon a famous clinic." — Journal of the Amtrican Midical .-tssori.ttion. Atlas and Epitome of External Diseases of the Eye. 15y Dr. O. Haai!, of Zurich. Indited by G. E. dk S( mweini 1 /, .M.D., Professor of (Ophthalmology, Jefferson .Medical College, Philadelpliia. With 76 colored illustrations on 40 plates, and 228 ])ages of text. Cloth, S3-oo net. " It is always difficult to represent pathological appearances in coloicij plates, liut liiis work Sfems to have overcome these difficulties, and the plate., with one or iwi^ exception.'-, are aitsoiutelv satisfactory." — lio-<lon Medical anil Sit'xicil /ourual. Atlas and Epitome of Skin Diseases. By 1'koi. Dr. I kan/ Mkacik, of \'ienna. I'-dited by Hinkv W. SrKLWA<;o\, M.D., Clinical Professor of Dermatology, Jefferson Medical College, I'hiladelphia. With 63 colored plates, 39 half-tone illustrations, and 200 j)ages of text. ( "loth, 53.50 net. "The imiH.rtance of personal inspection of c.nses in tiie study of rutaneuus discuses is readily apprec iated, and next to the living subjects are ]iictiires which will show tiie ap|>ear- ance of tiie disease under consideration. Altogether the work will be found of \cry great value to the general practitionei ." — J«ui ual of the American .Medical A^uicialion. SAUNDERS^ MEDICAL HAND-ATLASES, VOLUMES JUST ISSUED. Atlas and Epitome of Special Pathological Histology. By Dr. H. DiJRCK, of Munich, luiited by Ludvig Hektoex, M. L)., Professor of Pathology, Rush Medical College, Chicago. In Two Parts. Part I. Just Ready, including the Circulatory, Respiratory, and Castro- intestinal Tract, with 120 colored figures on 62 plates and 158 pages of text. Price, $3.00 net. Parts sold separately. Atlas and Epitome of Diseases Caused by Accidents. By Dr. Ed. (ioLEBiKWSKi, of Berlin. Translated and edited with additions by Pe.xrce B.viLEV, M. D., Attending Physician to the Department of Cor- rections and to the Almshouse and Incurable Hospitals, New York. ^^'ith 40 colored plates, 143 text-illustrations, and 600 pages of te.xt. Atlas and Epitome of Gynecology. By Dr. O. Schaffer, of Heidel- berg. Hdited by Richard C. Norris, A. M., M. D., Cynecologist to the Methodist I'-piscopal and the Philadelphia Hospitals; Surgeon-in- Charge of Preston Retreat, Philadelphia. With 90 colored plates, 65 text-illustrations, and 308 pages of text. IN PRESS FOR EARLY PUBLICATION. Atlas and Epitome of Obstetrical Diagnosis and Treatment. By Dr. O. Sch.\ffer, of Heidelberg. Edited by J. Clifton Edgar, M. D., Professor of Obstretics and Clinical Midwifery, Cornell Univer- sity Medical School. 72 colored plates, numerous text-illustrations, and copious text. Atlas and Epitome of the Nervous System and its Diseases. By Prof. Dr. A. vox Strumpell, of Erlangen. Edited by Edward D. Fisher, M. D., Professor of Diseases of the Nervous System, Univer- sity and l)el!e\ue Hosjjital Medical College, New York. 83 plates and a copious text. Atlas and Epitome of General Pathological Histology. With an Appendix on Pathohistological Technic. By Dr. H. Durck, of Munich. Edited bv Ludvig Hektoex, M. D., Professor of Path- ology, Rush Medical College, Chicago, ^^'ith So colored plates, numerous text-illustrations, and copious text. IN PREPARATION. Atlas and Epitome of Orthopedic Surgery. Atlas and Epitome of Operative Gynecology. Atlas and Epitome of Diseases of the Ear. Atlas and Epitome of General Surgery. Atlas and Epitome of Psychiatry. Atlas and Epitome of Normal Histology. Alias and Epitome of Topographical Anatomy. THE AMERICAN TEXT-BOOK SERIES. AN AMERICAN TEXT-BOOK OF APPLIED THERAPEUTICS. By 43 Distinguished Practitioners and Teachers. Edited by James C Wilson, M.D., Professor of the Practice of Medicine and of Clinical Medicine in the Jefferson Medical College, Philadelphia. One hand- some imperial octavo volume of 1326 pages. Illustrated. Cloth, $7.00 net ; Sheep or Half Morocco, $8.00 net. Sold by Subscription. " As a work either for study or reference it will be of great value to the practitioner, 2a it is virtually an exposition of such clinical therapeutics as experience has taught to be o; the most value. Taking it all in ail, no recent publication on therapeutics can be compared with this one in practical value to the working physician." — Chicai^o Clinical A'eTinv. ** The whole field of medicine has been well covered. The work is thoroughly prac- tical, and while it is intended for practitioners and students, it is a l)etter book for the genera] practitioner than for tlie student. The young practitioner esjiecially will find it extremely suggestive and helpful." — T/te Indian Lancet. AN AMERICAN TEXT-BOOK OF THE DISEASES OF CHILDREN. Second Edition, Revised. By 65 Eminent ( "ontributors. Edited by I, oris Stakr, M. D.. ("on- suiting I'ediatrist to the .Maternity Hospital, etc. ; a.s^isled by I'mo.mi'- so.N .S. \\i..>rL()ri , M. IJ., .Attending Physician to the Dispensary for Diseases of Children, Hospital of the Cniver^ity of I'eiinsyl- vania. in one handsome imi)erial o<ta\o volume of 1244 pages, profusely illustrated. Cloth, 57. 00 net; Sheep or Half Morocco, $8.00 net. Sold l>y Subscription. "This is far and away the I'cst text-book on children's diseases ever jiublislu'd in the Knglish language, and is curtainly tlie one which is be^t adapted to .Ameriean readers. ^V'e congratulate the editor upon the lesuk of his work, and heartily commend it to the mtention (^f every student and practitioner." — .XincriLan Journal of tin MrJical Siii-n<i-i. AN AMERICAN TEXT-BOOK OF DISEASES OF THE EYE, EAR, NOSE, AND THROAT. By 58 Prominent Specialists. Ivliied by 0. E. DK Scmwiimtz, M.D . Professor of 0|>hthalmology in the Jefferson Me(li(al College, Phila- delphia; and B. Ai.kxandkr Randai.i,, M.D., Professor of Di.seases of the Ear in the University of I*cnnsylvania. Imperial 0( tavo, 125 1 pages ; 766 illustrations, 59 of them in cohjrs. (loth, ^7. 00 net ; Sherp or Half Morocco, SS.oo .oet. Sold bv Subscrif>tion. Ukutrated Catalos:tie of the ** American Text-Booka" «ent free upon applicatiun. 6 Medical Publications of W. B. Saunders & Co. \N AMERICAN TEXT-BOOK OF QENITO-URINARY AND SKIN DISEASES. By 47 Eminent Specialists and Teachers. Edited by L. Boltom Bangs, M. D., Professor of Genito- Urinary Surgery, University and Bellevue Hospital Medical College, New York ; and W. A. Hard- AWAY, M. L)., Professor of Diseases of the Skin, Missouri Medical College. Imperial octavo volume of 1229 pages, with 300 engravings and 20 full-page colored plates. Cloth, $7.00 net; Sheep or Half Morocco, ;^8.oo net. Sold by Subscription. "This volume is one of the best yet issued of the publisher's series of ' American Text- Books.' The list of contributors represents an extraordinary array of talent and extended experience. The book will easily take the place in comprehensiveness and value of the half dozen or more costly works on these subjects which have heretofore been necessary to a well-equipped library." — New ]'orA Polyclinic. AN AMERICAN TEXT-BOOK OF GYNECOLOGY, MEDICAL AND SURGICAL. Second Edition, Revised. By 10 of the Leading Gynecologists of America. Edited by J. M. Baldv, M. D. , Professor of Gynecology in the Philadelphia Polyclinic, etc. Handsome imperial octavo volume of 718 pages, with 341 illus- trations in the text, and 38 colored and half-tone plates. Cloth, $6.00 net; Sheep or Half Morocco, $7.00 net. Sold by Subscription. " It is practical from beginning to end. Its descriptions of conditions, its recommen- dations for treatment, and above all the necessary technique of different operations, are clearly and admirably presented. . . . It is well up to the most advanced views of the day, and embodies all the essential points of advanced American gynecology. It is destined to make and hold a place in gynecological literature which will be peculiarly its own."^ Medical Record, New York. AN AMERICAN TEXT-BOOK OF LEGAL MEDICINE AND TOXI- COLOGY. Edited by Frederick Peterson, M.D., Clinical Professor of Mental Diseases in the Woman's Medical College, New York; Chief of Clinic, Nervous Department, College of Physicians and Surgeons, New York ; and Walter S. Haines, M.D., Professor of Chemistry, Pharmacy, and Toxicology in Rush Medical College, Chicago. /// Preparation. AN AMERICAN TEXT-BOOK OF OBSTETRICS. By 15 Eminent American Obstetricians. Edited by Richard C. Nor- Ris, M.D.; Art Editor, Robert L. Dickinson, M.D. One handsome imperial octavo volume of 1014 pages, with nearly 900 beautiful colored and half-tone illustrations. Cloth, $7.00 net; Sheep or Half Morocco, $8.00 net. Sold by Subscription. *' Permit me to say that your American Text-Book of Obstetrics is the most magnificent medical work that I have ever seen. I congratulate you and thank you for this superb work, which alone is sufficient to place you first in the ranks of medical publishers." — Ali'.xander J. C. SkeNk, Professor of Gynecology in the Long Island College Hospital, Brooklyn, N. V. " This is the most sumptuously illustrated work on midwifery that has yet appeared. In the number, the excellence, and the beauty of production of the illustrations it far surpasses every other l)ook upon the suljject. This feature alone makes it a work which no medical library should omit to purchase." — British Medical fonrnal. " /Vfi an authority, as a book of reference, as a ' working book ' for the student or prac- titioner, we commend it because we believe there is no better." — American Journal of tht \f''dical Sciences. Ultistrated Catalogue of the "American Text-Books " sent free upon application* Medical Publications of W. B. Saunders & Co. AN AMERICAN TEXT-BOOK OF PATHOLOGY. Edited by Ludvig Hektoen, M. D.. Professor of General Pathology and of Morbid Anatomy in the University of Pennsylvania ; and David Riesman, M. D., Demonstrator of Pathological Histology in the University of Pennsylvania. In preparation. AN AMERICAN TEXT-BOOK OF PHYSIOLOGY. By I o of the Leading Physiologists of America. Edited by William H. Howell, Ph.D., M.D., Professor of Physiology in the Johns Hop- kins University, Baltimore, Md. Second edition, revised and enlarged, in two volumes. " We can commend it most heartily, not only to all students of physiology, but to ever}' physician and pathologist, as a valuable and comprehensive work of reference, written by men who are of eminent authority in their own special suljects. " — London Lancet. " To the practitioner of medicine and to the advanced student this volume constitutes, we believe, the best exposition of the present status of the science of physiology in the English language." — American Journat of the Meduul Sciences. AN AMERICAN TEXT-BOOK OF SURGERY. Third Edition. By II Eminent Professors of Surgerv. Edited bv William W. Keen, M.D., LL.D., and J. William White, M.D , Ph.D. Handsome im- perial octavo volume of 1230 pages, with 496 woodcuts in the text, and 37 colored and half-tone plates. Thoroughly revised and enlarged, with a section devoted to " The Use of the Runtgen Rays in Surgery." Cloth, $7-0(5 net; Sheep or Half Morocco, $8.00 net. •' Personally, I should not mind it being called THE Ti:xT-Bof>K (instead of A Text- Book), for I know of no sinj^le volume which contains so readable and complete an account of the science and art of Surgery as this does." — IlDML'NI) Owi.N, I". K.C.S., Member of the Board of Examiners of the Koyai College <f Surgeons, England. •' If this text-book is a fair reflex of the present f)0>ition of American surgery, we must admit it is of a very high onk-r of merit, and that English surgeons will have to look very carefully to their laurels if they are to preserve a position in the van of surgical practice." — London Lancet. AN AMERICAN TEXT-BOOK OF THE THEORY AND PRACTICE OF MEDICINE. By 12 Distinguished American Practitioners. Edited by William Pepper, M.D., LL.D.. Professor of the Theory and Practice of Medi- cine and of Clinical Medicine in the University of Pennsylvania. Two handsome imperial octavo volumes of about 1000 pages each. Illus- trated. Prices per volume : Cloth. $5.00 net ; Sheep or Half Morocco, $6.00 net. Sold by Siibscriptio7t. " I am quite sure it will commend itself both to practitioners and students of medicine, and become one of our most popular t(Xt-l)Ooks.' — Al.KKKD EooMls, M.I)., LI,. I)., Lro- fessor of Pathology and Practice (f Medicine, Lnirersitv oj the City of A no }o>/:. " We reviewed the first volume of this work, an<l said : * It is undoubtedly one of the l)est text-l>f)oks on the practice of medicine whieli we ])ossess.' A consideration <T the second and last volume leads us to modify that verdict an<l to say that the comiilcted work is in our o]iiiiion ///.' best <A its kind it has ever l»en our fortune to see." — A'eit> ^'orh Medicad Journal. Illostrated Catalogue of the "American Text-Books" sent free upon applkation. 8 Medical Publications of W. B. Saunders & Co. AN AMERICAN YEAR-BOOK OF MEDICINE AND SURGERY. A Yearly Digest of Scientific Progress and Autlioritative Opinion in all branches of Medicine and Surgery, drawn from journals, monograplis, and text-books of the leading American and Foreign authors and investigators. Arranged with critical editorial comments, by eminent American specialists, under the general editorial charge of Geokcie M. Gould, M.I). Volumes for 1896, '97, '98, and '99. One imperial octavo volume of about 1200 pages. Cloth, $6.50 net ; Half Morocco, $7.50 net. Yearl)Ook of 1900 in two volumes — Vol. I., including General Medicine; \'ol. II., General Surgery. Prices per volume: Cloth, $3.00 net; Half Morocco, $3.75 net. Sold by Siibscriptiofi. " It is difficult to know which to admire most — the researcli and industry of the distin- guished band of experts whom Dr. Gould has enlisted in the service of the Year- Book, or the wealth and abundance of the contributions to every department of science that have been deemed worthy of analysis. ... It is much more than a mere compilation of abstracts, for, as each section is entrusted to experienced and able contributors, the reader has the advant- age of certain critical commentaries and expositions . . . proceedini» from writers fully qualified to perform these tasks. ... It is emphatically a book which should find a place in everv medical library, and is in sever.il respects more useful than the famous 'Jahrbiicher' of Germany." — London Lanwt. ABBOTT ON TRANSMISSIBLE DISEASES. The Hygiene of Transmissible Diseases ; their Causation, Modes of Dissemination, and Methods of Prevention. By A. C. Abbott, M.l)., Professor of Hygiene and Bacteriology, University of Pennsylvania ; Director of the Laboratory of Hygiene. Octavo volume of 311 pages, containing a number of charts and maps, and numerous illustrations. Cloth, $2.00 net. THE AMERICAN POCKET MEDICAL DICTIONARY. [See D or I and' s Pocket Dictionaty, page 12.] ANDERS' PRACTICE OF MEDICINE. Third Revised Edition. A Text-Book of the Practice of Medicine. By James M. Anders, M.D., Ph.D., LL.D. , Professor of the Practice of Medicine and of Clinical Medicine, Medico Chirurgical College, Philadelphia. In one handsome octavo volume of 1292 pages, fully illustrated. Cloth, $5.50 net; Sheep or Half Morocco, $6.50 net. " It is an excellent book, — concise, comprehensive, thorough, and up to date. It is a Credit to you ; but, more than that, it is a credit to the i)rofession of Philadelphia — to us." 1 \MES C. Wilson, Professor of the Practice of Medicine and Clinical Medicine, Jefferson Medical College, Philadelphia. ASHTON'S OBSTETRICS. Fourth Edition, Revised. Essentials of Obstetrics. By W. Easterly Ash ton, M.D., Pro- fessor of Gynecology in the Medico-Chirurgical College, Philadelphia. Crown octavo, 252 pages; 75 illustrations. Cloth, $1.00 net; inter- leaved for notes, S1.25 net. [See Saunders' Question- Conipends, page 23.] " Emliodies the whole subject in a nut-shell. We cordially reconmiend it to our read ers." — Chicago Aledical Tunes. Medical Publications of W. B. Saunders & Co. 9 BALL'S BACTERIOLOGY. Third Edition, Revised. Essentials of Bacteriology ; a Concise and Systematic Introduction to the Study of Micro-organisms. By M. V. Ball, M.D., Bacteriol- ogist to St. Agnes' Hospital, Philadelphia, etc. Crown octavo, 218 pages; 82 illustrations, some in colors, and 5 plates. Cloth, $1.00; interleaved for notes, $1.25. [See Saunders^ Question- Compends, page 23.] " The student or practitioner can readily obtain a knowledp;e of the subject from a perusal oi this book. The illustrations are clear and satisfactory." — Medical Record, New York. BASTIN'S BOTANY. Laboratory Exercises in Botany. Bv En^ox S. Bastin, M.A., late Prof, of Materia Medica and Botany, Philadelphia College of Phar- macy. Octavo volume of 536 pages, with 87 plates. Cloth, S2.00 net. "It is unquestionably the best text-book on the subject that has yet appeared. The work is eminently a practical one. We re^^ard the issuance of this hook as an important event in the history of pharmaceutical teaching in this country, .nnd predict for it an unquali- fied success." — Alumni Report to the Philadelphia College of Phan/iacv. BECK ON FRACTURES. Fractures. By Carl Bh:ck, M.D., Surgeon to St. Mark's Hosi)ital and the New York German Poliklinik, etc. 225 pages, 170 illustration^^. Cloth, $3.50 net. BECK'S SURGICAL ASEPSIS. A Manual of Surgical Asepsis. By Carl Bfxk, M.D , Surgeon to St. Mark's Hospital and the New York Cierman Poliklinik, etc. 306 pages; 65 text-illustrations, and 12 full-page plates. Cloth, $1.25 net. " An excellent exposition of the ' %'ery latest ' in thi" treatment of wounds a.s practised by leading L»ernian ami American surgeons." — Birimngluiiii (1-^ng. ) Medical Revie^u. '• Tiiis little volume can be recommended tn any who are desirous ol Ic.iriiing the d(.iaii> of asepsis in surgery, for it will serve as a iru.itworili}- guiile." — Loiuiou Ltiiuet. BOISLINIERE'S OBSTETRIC ACCIDENTS, EMERGENCIES, AND OPERATIONS. Obstetric Accidents, Emergencies, and Operations. I'y L. Ch. PjOISLLN'Ik.re, M.D., late i^iiKTitiis J'rolcssor of Obstetrics, St. Louis Medical College. 3S1 pages, handsomely illustrated. Cloth, <»2.oo net. " .\ manual so useful to the stuilciit or the g<-neral practitioner has not been brought to our notice in a long time. The field cmlirarcd in the tiile is covcn-d in a Icr^e, interesting way. " — Yale' Medical Jouniiil. BROCKWAY'S MEDICAL PHYSICS. Second Edition, Revised. Essentials of Medical Physics. Il\ 1'ki i> |. P.kot KWA^, M.D., Assistant Demonstrator of Anatomy in the ('olleL:eof Physicians and Surgeons, New"\'ork. (^"rown 0( lavo, 330 ])ag(s ; 155 fii;e illuslrations. Cloth, 51.00 net ; interleaved for notes, ^1.25 net. [S'.'c Sdii/idt-rs' Qucstion-Compciids, l)age 23. j "We know of no manual that affords the mcdiral "-Inilftit a bcllcr or more concise exposition of |)liy>ics, and the book may b" cnmmindcd a-, a mo>.t sati^lactory prociiLition of lllo^e (ssmtial-. that are rc(iui->itL- in a cour-.<-' in medicino." — Xe;,' W'rk Medical J. uriial. 10 Medical Publications of W. B. Saunders & Co. BUTLER'S MATERIA MEDICA, THERAPEUTICS, AND PHAR- MACOLOGY. Third Edition, Revised. A Text-Book of Materia Medica, Therapeutics, and Pharma- cology. By George F. Butler, Ph.G., M.D., Professor of Materia Medica and of Clinical Medicine in the College of Physicians and Surgeons, Chicago ; Professor of Materia Medica and Therapeutics, Northwestern University, Woman's Medical School, etc. Octavo, 874 pages, illustrated. Cloth, $4.00 net; Sheep, $5.00 net. *' Taken as a whole, the book may fairly be considered as one of the most satisfactory* of any single-voUime works on materia medica in the market." — Journal of the American Medical Association. CERNA ON THE NEWER REMEDIES. Second Edition, Revised. Notes on the Newer Remedies, their Therapeutic Applications and Modes of Administration. By David Cerna, M.D., Ph.D., formerly Demonstrator of and Lecturer* on Experimental Therapeutics in the University of Pennsylvania ; Demonstrator of Physiology in the Medical Department of the University of Texas. Rewritten and greatly enlarged. Post-octavo, 253 pages. Cloth, ^i. 00 net. "The appearance of this new edition of Dr. Cerna's very valuable work .shows that it is properly appreciated. The book ought to be in the po.ssession of every practising physi- cian." — Attc York A/cdical Journal. CHAPIN ON INSANITY. A Compendium of Insanity. By John B. Chapin, M.D., LL.D., Physician-in-Chief, Pennsylvania Hospital for the Insane ; late Physi- cian-Superintendent of the Willard State Hospital, New York ; Hon- orary Member of the Medico-Psychological Society of Great Britain, of the Society of Mental Medicine of Belgium. i2mo, 234 pages, illustrated. Cloth, $1.25 net. " The practical parts of Dr. Chapin's book are what constitute its distinctive merit. We desire especially to call attention to the fact that on the subject of therapeutics of insanity the work is exceedingly valual)le. It is not a made book, hut a genuine condensed thesis, which has all the value of ripe opinion and all the charm of a vigorous and natural style." — • Philadelphia Aledical Joui-?tal. CHAPMAN'S MEDICAL JURISPRUDENCE AND TOXICOLOGY. Second Edition, Revised. Medical Jurisprudence and Toxicology, By Henry C. Chapman, M.D., Professor of Institutes of Medicine and Medical Jurisprudence in the Jefferson Medical College of Philadelphia. 254 pages, with 55 illustrations and 3 full-page plates in colors. Cloth, $1.50 net. "The best book of its class for the undergraduate that we know of." — New York Medical Times. CHURCH AND PETERSON'S NERVOUS AND MENTAL DISEASES. Second Edition. Nervous and Mental Diseases. By Archibald Church, M. D., Professor of Clinical Neurology, Mental Diseases, and Medical Juris- prudence in the Northwestern University Medical School, Chicago ; and P'rederick: Pktkkson, M. D., Clinical Professor of Mental Dis- eases, Woman's Medical College, N. Y. ; Chief of Clinic, Nervous Dept., College of Physicians and Surgeons, N. Y. Handsome octavo volume of 843 pages, profu.sely illustrated. Cloth, $5.00 net; Half Morocco, $6,00 net. Medical Publicntions of W. B. Saunders & Co. 11 CLARKSON'S HISTOLOGY. A Text-Book of Histology, Descriptive and Practical. By Arthur Clarkson, M.B., CM. Edin., formerly Demonstrator of Physiology in the Owen's College, Manchester; late Demonstrator of Physiology in Yorkshire College, Leeds. Large octavo, 554 images; 22 engravings in the text, and 174 beautifully colored original illustra- tions. Cloth, strongly bound, 34.00 net. " The work must be considered a valuable addition to the list of available text books, and is to be highly recommended." — jVe7o York Medical Journal. "This is one of the best works for students we have ever noticed. We predict that the book will attain a well-deserved popularity among our students." — 6'/;?Vtf^'0 Mimical Recorder. CLIMATOLOGY. Transactions of the Eighth Annual Meeting of the American Climatological Association, held in Washington, September 22-25, 1891. Forming a handsome octavo volume of 276 l)ages, uniform with remainder of series. (A limited quantity only.) Cloth, §1.50. COHEN AND ESHNER'S DIAGNOSIS. Second Edition, Revised. Essentials of Diagnosis. By Solomon Solis-Cohkx, M.D., Pro- fes.sor of Clinical Medicine and Applied Therapeutics in the Philadel- phia Polyclinic ; and Augustus k. Eshner. M.D., Professor of Clinical Medicine in the Philadelphia Polyclinic. Post-octavo, 417 pages; 55 illustrations. Cloth, gi.oo net. [See Saunders Question- Compcnds, page 23.] "We can lieartily commend the lif)ok to all those who contemplate ]iurchasing a ' com- pend.' It is modern and complete, and will give more satisfaction than many otlier works which are perhaps too prolix as well as behind the times." — Medical Ke^'irui, St. Louis. CORWIN'S PHYSICAL DIAGNOSIS. Third Edition, Revised. Essentials of Physical Diagnosis of the Thorax. By Akphur AL CoKWiN, A.NL, M.l)., Demonstrator of Physical Diagnosis in Rush Medical College, Chicago ; Attending Physician to Central Free Dis- ])ensary, Dejjartment of Rhinology, Laryngology, and Diseases of the Chest, Chicago. 219 pages, illustrated. Cloth, Ik- .xiblc covers, ^1.25 net. " It is excellent. The student who shall use it as his guide to tlie careful study of physical exjiloration ujjon normal and abmiriual subi<Tt> (an scarcely fail to accjuirc a good working knowledge ()f the subject." — I'hi'dJ' Ipliui J\>/\\/i>iic. ".\ most excellent little work. It biii;litctis the iiieinciry nf the ditt'erentiid di.ignostic signs, and it .irranges orderly .-iiKl in -ciiiuncc tiie \arious objective phenomena to logic. il solution of a careful diagnosis." — Joitrudl of .VerToiis and Menltil Diseases. CRAQIN'S GYN/ECOLOGY. Fourth Edition, Revised. Essentials of Gynaecology. I'.y 1j>\vin 1!. Ckacin. M. D.. Let turcr in Obstetrics, Ctjllcgc of i'hy.sicians and Surgeons, .New NOrk. < lown o(la\(). 200 jjagcs ; 62 illu>ti.iii()n>. (loth, ^l.oo net; intcrlca\ ed tor noto, S' -25 net. [See Sauni/rrs' Qu,stion-C<nnprnds, i)age 2,^.] " .\ handy volume. aii<l a distinct inii'rovcm<-iit on .students' cmix-nds in g<nenil. No author\vh o w Is imi hiin~elf a practical gynec..loL;i-.t cnuM have cnnMihed the Nludent'.s needs so ihorougidy a.^ Dr. ( ra^jin has i.V,\\fi:' — Mcdnal Record, .\c\v \<.ik. 12 Meaical Publications of W. B. Saunders & Co. CROOKSHANK'S BACTERIOLOGY. Fourth Edition, Revised. A Text-Book of Bacteriology. By Edgar M. Crookshank, M.B., Professor of Comparative Pathology and Bacteriology, King's College, London. Octavo volume of 700 pages, with 273 engravings and 22 original colored plates. Cloth, $6.50 net; Half Morocco, $7.50 net. " To the student who wishes to obtain ix pood rhuvii of what has been done in bacteri- ology, or who wishes an accurate account of the various methods of research, the book may be recommended with contiilence that he will Ihid there what he requires." — London Lancet. Oa COSTA'S SURGERY. Second Ed., Revised and Greatly Enlarged. Modern Surgery, General and Opentive. By John Chalmers DaCosta, M. 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One which we can commend to students as a reliable text-book, written with an evident knowledge of the wants of those entering upon the study of this special branch of medical science." — British Medical Journal. " A work that will meet the requirements not only of the specialist, but of the general practitioner in a rare degree. I am satisfied that unusual success awaits it." — William Pepper, M.D., Professor of the Theory aftd Practice of Medicine and Clinical Medicine. University of Pennsylvania. DORLAND'S DICTIONARY. Third Edition, Revised. The American Pocket Medical Dictionary. Containing the Pro- nunciation and Definition of all the principal words and phrases, and a large ninnber of useful tables. P^dited by W. A. Newman Borland, M. D., Assistant Demonstrator of Obstetrics, University of Pennsylvania; Fellow of the American Academy of Medicine. 518 pages ; handsomely bound in full leather, limp, with gilt edges and patent index. Price, $1.00 net; with thumb index, $1.25 net. DORLAND'S OBSTETRICS. A Manual of Obstetrics. By W. A. Newman Borland, M.B., Assistant Denionstralor of Obstetrics, University of Pennsylvania ; Instructor in Gynecology in the Philadelphia Polyclinic. 760 pages; 163 illustrations in the text, and 6 full-page plates. Cloth, 32.50 net. " By far the best book on this subject that has ever come to our notice." — American Medical Review. " It has rarely been our duty to review a book which has given us more pleasure in its perusal and more satisfaction in its criticism. It is a veritable encyclopedia of knowledge, a gold mine of practical, concise thoughts." — American Medico-Surgical Bulletin. Medical Publications of W. B. Saunders & Co. 13 PROTHINQHAM'S GUIDE FOR THE BACTERIOLOGIST. Laboratory Guide for the Bacteriologist. By Langdon Froth- INGHAM, M.D.V., Assistant in 15acteriology and Veterinary Science, Sheffield Scientific School, Yale University. Illustrated. Cloth, 75 cts. "It is a convenient and useful little work, and will more than repay the outlay neces- sary for its purchase in the savint; of time whicii would otherwise be consumed in looking up the various points of technique so clearly and concisely laid down in its pages." - Ameri- can Meiiico- Surgical Bulletin. GARRIGUES' DISEASES OF WOMEN. Third Edition, Revised. Diseases of Women. By Henry J. Garrigues, A.M., M.D., Pro- fessor of Gynecology in the New York School of Clinical Medicine; Gynecologist to St. Mark's Hospital and to the German Dispensary, New York City, etc. Handsome octavo volume of 7CS3 pages, illus- trated by 367 engravings and colored plates. Cloth, $4.00 net; Sheep or Half Morocco, $5.00 net. '• One of the heat text-books for students and practitioners which has been published in the English language ; it is condensed, clear, and comprehensive. The profound learning and great clinical experience of the distinguished author tind expression in this book in a most attractive and instructive form. Young practitioners to whom experienced consultants may not be available will tind in this book invaluable counsel and hel|i." — Thad. A. ReaMV, M.D., LL.D., Professor of Clinical gynecology. Medical College of Ohio. GLEASON'S DISEASES OF THE EAR. Second Edition, Revised. Essentials of Diseases of the Ear. ]\y K. I). (Jlkasox, S.B., M.D., Clinical Professor of Otology, Medicu-Chirurgical College, Philadelphia ; Surgeon-in-Charpe of the Nose, Tliroat. and Ear Depart- ment of the Northern Dispensary, Philadelphia. 20.S pages, with 114 illu-strations. Cloth, Si. 00 net; interleaved for notes, Si. 25 nei. [See Saimders' Question- Compends, page 23.] " It is just the book to put into the hands of a student, and cannot fail to give him a useful intro<iuction to ear-affections ; while the style of cjuestion aiid answer which is adopted throughout the hook is, we lielieve, the best method of impressing tacl> permanently on the mind." — Liverpool .Medico- Chirurgical Jourtia I. GOULD AND PYLE'S CURIOSITIES OF MEDICINE. Anomalies and Curiosities of Medicine. Bv GioRCii; M. Gould, M.D.,and Walter L. Pvle, M.D. An encyclopedic collection of rare and extraordinary cases and of the most striking instances of abnormality in all branches of Medicine and Surgery, derived from an exhaustive research of medical literature from its origin to the present day, abstracted, classified, annotatefl, and indexed. Handsome im- I)erial octavo volmne of 968 pages, with 295 engravings in the text, and \2 lull-page plates. POPULAR EDITION: Cloth, $3.00 net. Half Morocco, $4.00 net. "f)ne of the most valuable contribution^ cvrr made lo m<<li( al lit( lature I> i-. 'o far a^ we know, absolutely unique, and every page is a."^ (ascmating a> a tiovd. .\(.| aKme for the medical profession has this volume value: it will ^civi- a^ a IkkiK of rclerciMC lor ;ill who are interested in general scientific, sociologic, or niediri> legal t<'pi(s." — /■>>,<< l-!\)i .Medical I urnal. "This is c<-rtainly a most remarkable and itiKi. Ming volume-. It sl.iiid- alone among nw-Ueal literature, ati anomaly on anomalie-. in th.it there is nothing like it el.scwhere in medical literature. It is a lMM)k full of revehiiion, fn.m its first to its last page, and euinot but interest and sometimes almost horrify its iea<lers." — Americnt Medi. o-Surgual JUtlletin. 14 Medical Publications of W. B, Saunders & Co. GRAFSTROM'S MECHANO-THERAPY. A Text-Book of Mechano-Therapy (^Massage and Medical Gym- nastics). By AxKL \'. Orafstrom, B. Sc, M. U., late Lieutenant in the Royal Swedish Army ; late House Physician City Hospital, Black- well's Island, New York. 1 2mo, 139 pages, illustrated. Cloth, ^i.oo net. GRIFFITH ON THE BABY. Second Edition, Revised. The Care of tfie- Baby. By J- P- Crozer Griffith, M.D., Clini- cal Professor of Diseases of Children, University of Pennsylvania; Physician to the Children's Hospital, Philadelphia, etc. i2mo, 404 pages, with 67 illustrations in the text, and 5 plates. Cloth, $1.50 net. " The best book for the use of the young mother with which w-e are acquainted. . . . There are very few general practitioners who could not read the book through with advan- tage. ' ' — Archives of Pediatrics. " The whole lx)ok is characterized by rare good sense, and is evidently written by a master hand. It can be read with benefit not only by mothers but by medical students and by any practitioners who have not had large opjx)rtunities for observing children." — Ameri- can Journal of Obstetrics. GRIFFITH'S WEIGHT CHART. Infant's Weight Chart. Designed by J. P. Crozer Griffith, M. D. , Clinical Professor of Diseases of Children in the University of Penn- sylvania, etc. 25 charts in each pad. Per pad, 50 cents net. GROSS, SAMUEL D., AUTOBIOGRAPHY OF. Autobiography of Samuel D. Gross, M. D., F^meritus Professor of Surgery in the Jefferson Medical College, Philadelphia, with Remi- niscences of His Tiines and Contemporaries. Edited by his Sons, Samuel W. Gross, M.D., LL.D., and A. Haller Gross, A.M. Pre- ceded by a Memoir of Dr. Gross, by the late Austin Flint, M.D. Two handsome volumes, over 400 pages each, demy octavo, gilt tops, with Frontispiece on steel. Price per volume, $2.50 net. HAMPTON'S NURSING. Second Edition, Revised and Enlarged. Nursing: Its Principles and Practice. By Isabel Adams Hamp ton, Graduate of the New York Training School for Nurses attached to Bellevue Hospital ; late Superintendent of Nurses and Principal of the Training School for Nurses, Johns Hopkins Hospital, Baltitnore, Md. 12 mo, 512 pages, illustrated. Cloth, $2.00 net. " Seldom have we perused a book upon the subject that has given us so much pleasure as the one before us. We would strongly urge upon the members of our own profession the need of a book like this, for it will enable each of us to become a training school in him- self." — Ontario Medical Jonrnal. HARE'S PHYSIOLOGY. Fourth Edition, Revised. Essentials of Physiology. By H. A. Hare, M.D., Professor of Therapeutics and Materia Medica in the Jefferson Medical College of Philadelphia. Crown octavo, 239 pages. Cloth, $1.00 net; inter- leaved for notes, $1.25 net. [See Sautiders' Question- Comfends, page 23.] "The best condensation of physiological knowledge we have yet seen." — Medicai Record, New York. Medical Publications of W. B. Saunders & Co. 15 HART'S DIET IN SICKNESS AND IN HEALTH. Diet in Sickness and in Health. By Mrs. Ernest Hart, formerly Student of the Faculty of Medicine of Paris and of the London School of Medicine for Women ; with an Introduction by Sir Henry Thompson, F.R.C.S., M.D., London. 220 pages. Cloth, $1.50 net. " We recommend it cordially to the attention of all practitioners ; both to them and to their patients it may be of the greatest service." — Xeiv York Medical Journal. HAYNES' ANATOMY. A Manual of Anatomy. By Irving S. Havnes, M.D., Adiunct Professor of Anatomy and Demonstrator of Anatomy, Medical Depart- ment of the New York University, etc. 680 pages, illustrated with 42 diagrams in the text, and 134 full-page half-tone illustrations from original photographs of the author's dissections. Cloth, $2.50 net. " This book is the work of a practical instructor — one who knows by exjierience the requirements of the average student, and is able to meet these requirements in a very satis- factory way. The book is one that can be commended." — Medical Record, New York. HEISLER'S EMBRYOLOGY. A Text-Book of Embryology. By John C. Heisler, M.D., Pro- lessor of Anatomy in the Medico-Chirurgical College, Philadelphia. Oc- tavo volume of 405 pages, handsomely illustrated. Cloth, $2.50 net. HIRST'S OBSTETRICS. Second Edition. A Text-Book of Obstetrics. By Barton Cooke Hirst, M. D., I^rofessor of Obstetrics in the University of Pennsylvania. Handsome octavo volume of 848 pages, with 618 illustrations, and 7 colored plates. Cloth, $5.00 net; Sheep or Half Morocco, 56.00 net. "The illustrations are numerous and are works of art, many of them ajipearing for the first lime. The arranj^ement of the subject-matter, the foot-notes, and index arc l)eyond criticism. As a true model of what a modern text-book on oi)stetrics should be, \\ c feel justitieii in affirming that Dr. Hirst's book is without a rival." — A'cw York Medical Record. HYDE AND MONTGOMERY ON SYPHILIS AND THE VENEREAL DISEASES. Second Edition, Revised and Enlarged. Syphilis and the Venereal Diseases. Bv [amis .\i\in> Hvdk, M. 1)., Professor of Skin and \enereal Diseases, and I-kank \\. .Mon 1- ooMKKV, M. D., Lecturer on Dermalolog) and Cenito-L'rinary Diseases in Rush .Medical College. Chicago, 111. ()cta\o. nearly 600 pages, with 14 beautiful lithographic plates and numerous illustrations. " We can commend this manual to the student as a help to him in his >tudy of veneica! diseases." — Liverpool Medico-Chirurs^ical Journal. "The l)est student's manual which has ap|)eared on the subject.'' — St. Louts. AUdiioJ gnd .Surgical Journal. INTERNATIONAL TEXT-BOOK OF SURGERY. In two volunus i!v American and i'.ritish authors. Lditcd li\ j. Cmi.i ins ANakkin. NLI).. LL.l)., Professor of Surgerv. Harvard Mcdicil Si hool. Iloston ; and A. I'kakce C.on.i), .M.S.! K.R.C.S.. l,<(tiircr on I'r.i. ti.al Sur- gerv and Teacher of Ojjcrative Snrgcrw Mid.ilcscx ilosiiital Mcdii.al School. London. ICng. \'ol. I. C,V//./w/ .S'///;',-/! - 1 landsonic o( lavo, 947 !>;ig*^'>. \v'lli 4.v'"» beautitid illustrations rind <; lithographic jilalcs. Vol.' II. Sprciiil or /vV;vc;;a// .SV//;;'rn . -1 Ian<lsome octavo. 107.' pages, with 471 beautiful illustrations and S lithographic plates. Prices per volume: ("loth, ^5.00 net; Hall .Morocco. ■$,(■>. 00 net. • Ui Medical Publications of W. B. Saunders & Co. JACKSON'S DISEASES OF THE EYE. A Manual of Diseases of the Eye. By Edward Jackson, A.M., M.D., sometime Professor of Diseases of the Eye in the Philadelphia Polyclinic and College for (Graduates in Medicine. i2mo volume of 535 I^ges, with 178 beautiful illustrations, mostly from drawings by the author. Cloth, $2.^0 net. JACKSON AND QLEASON'S DISEASES OF THE EYE, NOSE, AND THROAT. Second Edition, Revised. , Essentials of Refraction and Diseases of the Eye. By Edward Jackson, A.M., M.D., Professor of Diseases of the Eye in the Phila- delphia Polyclinic and College for Graduates in Medicine; and — Essentials of Diseases of the Nose and Throat. By E. Bald- win Gleason, M.D., Surgeon-in-Charge of the Nose, Throat, and Ear Department of the Northern Dispensary of Philadelphia. Two volumes in one. Crown octavo, 290 pages ; 124 illustrations. Cloth, $1.00 net; interleaved for notes, $1.25 net. [See Saunders' Question- Compends, page 22.] " Of great value to the beginner in these branches. The authors are both capable men, and know what a student most needs." — Medical Record, New York. KEATING'S DICTIONARY. Second Edition, Revised. A New Pronouncing Dictionary of Medicine, with Phonetic Pronunciation, Accentuation, Etymology, etc. By John M. Keating, M.D., LL.D., Fellow of the College of Physicians of Phila- delphia, and Henry Hamilton ; with the collaboration of J. Chal- mers DaCosta, M.D., and Frederick A. Packard, M.D. With an Appendi.K containi g Tables of Bacilli, Micrococci, Leucomaines, Ptomaines, etc. One volume of over 800 pages. Prices, with Ready- Reference Index: Clrth, $5.00 net; Sheep or Half Morocco, $6.00 net. Without Patent Index: Cloth, $4.00 net; Sheep or Half Morocco, $5.00 net. "I am much pleased with Keating's Dictionary, and shall take pleasure in recommend- ing it to my classes." — Henry M. Lymax, M. D., Professor of the Pri)iciples and Practice ■>f Medicine, Pi./i Medical College, Chicago, III. KEATING'S LIFE INSURANCE. How to Examine for Life Insurance. By John M. Keating, M.D., Fellow of the College of Physicians of Philadelphia; Vice- President of the American Prediatric Society; Ex- President of the Association of Life Insurance Medical Directors. Roval octavo, 211 pages ; with two large half-tone illustrations, and a plate prepared by Dr. McClellan from special dissections ; also, numerous other illustra- tions. Cloth, $2.00 net. KEEN'S OPERATION BLANK. Second Edition, Revised Form. An Oper-'tion Bl .ik, with Lists of Instruments, etc., Required in Various Operations. Prepared by W. W. Keen, M.D., LL.D., Professor of the Principles of Surgery in Jefferson Medical College, Philadelphia. Price per pad, blanks for fifty operations, 50 cents net. Medical Publications of W. B. Saunders dt Co. 17 KEEN ON THE SURGERY OF TYPHOID FEVER. The Surgical Complications and Sequels of Typhoid Fever, By Wm. W. Keen, M.D., LL.D., Professor of the Principles of Sur- gery and of Clinical Surgery, Jefferson Medical College, Philadelphia; Corresponding Member of the Soci^te de Chirurgie, Paris ; Honorary Member of the Society Beige de Chirurgie, etc. Octavo volume of 386 pages, illustrated. Cloth, ^3.00 net. " This is probably the first and only work in the English language that gives the reader a clear view of what typhoid fever really is, and what it does and can do to the human organism. This book should i)e in the possession of every medical man in America." — AmfHcan MeJico-Surgical Bulletin. KYLE ON THE NOSE AND THROAT. Diseases of the Nose and Throat. By D. Braden Kyle, M.D., Clinical Professor of Laryngology and Rhinology, Jefferson Medical College, Philadelphia; Consulting Laryngologist, Rhinologist, and Otologist, St. Agnes' Hospital. Handsome octavo volume of about 630 pages, with over 150 illustrations and 6 lithographic plates. Price, Cloth, $4.00 net; Half Morocco, $5.00 net. LAINE'S TEMPERATURE CHART. Temperature Chart. Prepared by D. T. Laine, M.D. Size 8 x i^y^ inches. A conveniently arranged Chart for recording Temperature, with columns for daily amounts of Urinary and Fecal Excretions, Food, Remarks, etc. On the back of each chart is given in full the method of Brand in the treatment of Typhoid Fever. Price, per pad of 25 charts, 50 cents net. "To the busy practitioner this chnrt will be found of great value in fever cases, and especially for cases of typhoid." — Indiari Lancet, Calcutta. LEVY AND KLEMPERER'S CLINICAL BACTERIOLOGY. The Elements of Clinical Bacteriology. By Dr. IOrnst Lkvv, Profes- sor in the I'niversity of Strassburg, and Fklix Ki.k.mpkrek, Privat docent in the University of Strassbur-^. Translated and edited by .Augustus A. lCs}iNKK, M.I)., Professor of (Clinical Medicine in the Philadelphia Polyclinic. Octavo, 440 pages, fully illustrated. Cloth, $2.50 net. LOCKWOOD'S PRACTICE OF MEDICINE. A Manual of the Practice of Medicine. By George Roe Lock- wood, M.D., Professor of Practice in the Woman's Medical C"ollei;e of the New York Infirmary, etc. 935 pages, with 75 illiislnuions in the text, and 22 full-page j^lates. Cloth, $2.50 net. "Gives in a most concise manner the points cssoutial to treatment usually enumcrrtcc in the most clalxirale works." — Massailiitsetts Mt\li((ii Journal. LONG'S SYLLABUS OF GYNECOLOGY. A Syllabus of Gynecology, arranged in Conformity with " An American Text-Book of (iynecology." By J. \\. Long. M.D , Professor of Diseases of W'cjnicn and (hildreii, Medical College of Virginia, etc. Cloth, interleaved, ;«;i.oo net. " Tlie l>orjk is certainly an adniiralilc ;rf/^///r of what every ^ynocdlo^ical stuilriit nii'' practitioner should know, and will ])r<>ve of vahic not only to those who have tlit; ' -Ameruai Text-Hook of ( iyiieeoloj^'V, l)Ul to olh'TS as well. " — Htool;lyu Mfiiiciil Jouina!. 2 18 Medical Publications of W. B. Saunders & Co. MACDONALD'S SURGICAL DIAGNOSIS \ND TREATMENT. Surgical Diagnosis and Treatment. By J- W. Macdonald, M.D. Edin., F.R.C.S., Kdin., Professor of the Practice of Surgery and of Clinical Surgery in Hamline University ; Visiting Surgeon to St. Barnabas' Hospital. Minneapolis, etc. Handsome octavo volume of 800 pages, profusely illustrated. Cloth, $5.00 net; Half Morocco, $6.00 net. " A thorough and complete work on surgical diagnosis and treatment, free from pad- ding, full of valuable material, and in accord with the surgical teaching of the day. " — 7Vif Medical News, Ne'w York. "The work is brimful of just the kind of Practical information that is useful alike to students and practitioners. It is a pleasure to commend the bock because of its intrinsic value to the medical practitioner." — Cincinnati Lancet- Clinic MALLORY AND WRIGHT'S PATHOLOGICAL TECHNIQUE. Pathological Technique. A Practical Manual for Laboratory Woik in Pathology, Bacteriology, and Morbid Anatomy, wich chapters on Post-Mortem Technique and the Performance of Autopsies. By Frank B. Mallory, A.m., M.D., Assistant Professor of Pathology, Harvard University Medical School, Boston; and James K. Wright, A.M., M.D., Instructor in Pathology, Harvard University Medif:al School, Boston. Octavo volume of 396 pages, handsomely illustrated. Cloth, $2.50 net. " I have been looking forward to the publication of this book, and I am gi.Td to say that I find it to be a most useful laboratory and post-mortem guide, full of practical information, and well up to date." — William H. Welch, Professor of Pathology, fohns Hopkins Uni- versily, Baltitnore, Md. MARTIN'S MINOR SURGERY, BANDAGING, AND VEiiNEREAL DISEASES. Second Edition, Revised. Essentials of Minor Surgery, Bandaging, and Venoreal Diseases. By Edwvrd Marti.v, A.M., M.D., Clinical Professcrof Genito-Urinary Diseases, Univ^ersity of Pennsylvania, etc. Crown octavo, 166 pages, with 78 illustrations. Cloth, $1.00 net; interleaved for notes, $1.25 net. [See Saunders' Questioji-Compends, page 23.] "A very practical and systematic study of the subjects, and shows the author's famil- iarity with the needs of students." — Therapetitic Gazette. MARTIN'S SURGERY. Seventh Edition, Revised. Essentials of Surgery. Containing also \'enereal Diseases, Surgi- cal Landmarks, Minor and Operative Surgery, and a complete de- scription, with illustrations, of the Handkerchief and Roller Bandages. By Edward Martin, A.M., M.D., Clinical Professor of Genito- Urinary Diseases, L^niversity of Pennsylvania, etc. Crown octavo, 342 pages, illustrated AVith an Appendix on the preparation of the materials used in Antisejjtic Surgery, etc., and a chapter on Appendicitis. Cloth, $1.00 net ; interleaved for notes, 5! 1-25 net \^tQ. Saunders'' Question- Compends, page 23.] " Contains all necessary essentials of modern surgery in a comparativelv small space. Its style is interesting, and its illustrations are admirable." — Afedical and Surgical Peforter. Medical Publications of W. B. Saunders & Co, 19 McFARLAND'S PATHOGENIC BACTERIA. Second Edition, Re- vised and Greatly Enlarged. Text-Book upon the Pathogenic Bacteria. By Joseph McFar- LAND, M. D., Professor of Pathology and Bacteriology in the Medico- Chirurgical College of Philadelphia, etc. Octavo volume of 497 pages, finely illustrated. Cloth, $2.50 net. " Dr. McF'arland has treated the subject in a systematic manner, and has succeeded in presenting in a concise and readable form the essentials of bacteriology up to date. Alto- gether, the book is a satisfactory one, and I shall take pleasure in recommending it to the students of Trinity College." — H. B. Anderson, M. D. , Professor of Pathology and Bac- teriology, Trinity Medical College, Torottto. MEIGS ON FEEDING IN INFANCY. Feeding in Early Infancy. By Arthur V. Meigs, M.D. Bound in limp cloth, flush edges, 25 cents net. "This pamphlet is worth many times over its price to the physician. The author's exfjeriments and conclusions are original, and have been the means of doing much good." — Medical Bulletin. MOORE'S ORTHOPEDIC SURGERY. A Manual of Orthopedic Surgery. By James E. Moore, M.D., Professor of Orthopedics and Adjimct Professor of Clinical Surgery, University of Minnesota, College of Medicine and Surgery. Octavo volume of 356 pages, handsomely illustrated. Cloth, $2.50 net. "A most attractive work. The illustrations and the care with which the book is adapted to the wants of the general practitioner and the student are worthy of great praise." — Chicago Medical Recorder. "A very demonstrative work, every illustration of which conveys a lesson. The work is a most excellent and cummendable one, which we can certainly entiorse with pleasure." — St. Louis Medical and Surgical Journal. MORRIS'S MATERIA MEDICA AND THERAPEUTICS. Fifth Edition, Revised. Essentials of Materia Medica, Therapeutics, and Prescription- Writing. By Henry Mokkis, M.D., late Demonstrator of Thera- peutics, Jefferson Medical College, Phila(lel{)hia , Fellow of the College of Phvsicians. Philadcl|)hia, etc. Crown octavo, 28S jiages. Cloth, gi.oo net; interleaved for notes, ,si.25 net. [See Saun tiers' Question- Contpends, page 22.] "This work, already excellent in the old edition, has ieen largely improved by revi- sion." — American J'raclitioncr and A'eivs. MORRIS, WOLFF. AND POWELL'S PRACTICE OF MEDICINE. Third Edition, Revised. Essentials of the Practice of Medicine. r)y Hfnkv >[()Kris, M.D., late Demonstrator of rherapeutics, Jefferson Meditai College, Phila- delpiiia; with an .Appendix on the Clinical and Microscopic Ivxamina- tion of Urine, by L/vwhknck Woi.i k. M.D. . Demonstrator of Chemistry, Jefferson Medical College, IMiiladel|)hia. I'lnlarged hv some 300 es-sen- tial formulru collected and arranged by Wii.i.iam M. J'owkll, M.D. Post-octavo, .488 pages, ("loth. 51.50 net. [See Saunders' Question- Compends, page 22.] " Tlie teaching is sound, the prcscit itinn graphic ; in.UliT full as can be desired, •\arj style attractive." — American Practiii^'iiir ,itid \c7iis. 20 Medical Publications of W. B. Saunders & Co. MORTEN'S NURSE'S DICTIONARY. Nurse's Dictionary of Medical Terms and Nursing Treat- ment. Containing Definitions of the Principal Medical and Nursing Terms and Abbreviations ; of the Instruments, Drugs, Diseases, Acci- dents, Treatments, Operations, Foods, Appliances, etc. encountered in the ward or in the sick-room. By Honnor Morten, author of " How to Become a Nurse," etc. i6mo, 140 pages. Cloth, $1.00 net. " \ handy, compact little volume, containing a large amount of general information, all of which is arranged in dictionary or encyclopedic form, thus facilitating quick reference. It is certainly of value to those for whose use it is published." — Chicago Clinical Review. NANCREDE'S ANATOMY. Sixth Edition, Thoroughly Revised. Essentials of Anatomy, including the Anatomy of the Viscera. By Charles B. Nancrede, M.D., LL.D., Professor of Surgery and of Clinical Surgery in the University of Michigan, Ann Arbor. Crown octavo, 420 pages; 151 illustrations. Based upon Gray's Anatomy. Cloth, Si-oo net; interleaved for notes, $1.25 net. [See Saunders' Question- Compends, page 23.] " For self-quizzing and keeping fresh in mind the knowledge of anatomy gained at school, it would not be easy to speak of it in terms too favorable." — American Practitioner. NANCREDE'S ANATOMY AND DISSECTION. Fourth Edition. Essentials of Anatomy and Manual of Practical Dissection. By Charles B. Nancrede, M.D., LL.D., Professor of Surgery and of Clinical Surgery, University of Michigan, Ann Arbor. Post-octavo ; 500 pages, with full-page lithographic plates in colors, and nearly 200 illustrations. Extra Cloth (or Oilcloth for dissection-room), ^2.00 net. " It may in many respects be considered an epitome of Gray's popular work on general anatomy, at the same time having some distinguishing characteristics ot its own to commend u The plates are of more than ordinary excellence, and are of especial value to students ill their work in the dissecting room." — Jotanat of the American Medical Association. NANCREDE'S PRINCIPLES OF SURGERY. Lectures on the Principles of Surgery. By Chas. B. Nancrede, M.D , LL.D., Professor of Surgery and of Clinical Surgery, Univer- sity of Michigan, Ann Arbor. Octavo volume of 398 pages, illustrated. Cloth, $2. 50 net. NORRIS'S SYLLABUS OF OBSTETRICS. Third Edition, Revised. Syllabus of Obstetrical Lectures in the Medical Department of the University of Pennsylvania. By Richard C. Norkis, A.M., M.D., Demonstrator of Obstetrics, University of Penns) b.ania. _ Crown octavo, 222 i)ages. Cloth, interleaved for notes, $2.00 net. PENROSE'S DISEASES OF WOMEN. Third Edition, Revised. A Text=Book of Diseases of Women. By Charles B. Penrose, M.D., Ph.D., Formerly Professor, of Gynecology in the LTniversity of Pennsylvania; Surgeon to the (jvnecean Hospital, Philadeljjhia. Octavo volume of 531 pages, handsomely illustrated. Cloth, $3.75 net. "I .shall value very highly the copy of Penrose's • Di.seases of Women' received. I have already recommended it to my class as THE BEST book." — Howard K. Kelly. Prof ssor of Gynecology and Obstetrics, Johns Hopkins Unuiersity, Baltii/ioie, Aid. Medical Publications of W. B. Saunders & Co. 21 POWELL'S DISEASES OF CHILDREN. Second Edition. Essentials of Diseases of Children. By William M. Powell, M.D., Attending Physician to the Mercer House for Invalid Women at Atlantic City, N. J. ; late Physician to the Clinic for the Diseases of Children in the Hospital of the University of Pennsylvania. Crown octavo, 222 pages. Cloth, gi.oonet; interleaved for notes, $1.25 net. [See Saunders' Question-Compends, page 21.] "Contains the gist of all the best works in the department to which it relates."— ^ American Practitioner and A^e^us. PRINGLE'S SKIN DISEASES AND SYPHILITIC AFFECTIONS. Pictorial Atlas of Skin Diseases and Syphilitic Affections (American Edition). Translation from the French. Edited by J. J. Pringle, M.B., F.R.C.P., Assistant Physician to the Middlesex Hospital, London. Photo-lithochromes from the famous models in the Museum of the Saint-Louis Hospital, Paris, with explanatory wood- cuts and text. In 12 Parts. Price per Part, S3. 00. Complete in one volume. Half Morocco binding, §40.00 net. " I strongly recommend this Atlas. The plates are exceedingly well executed, and urill be of great value to all studying dermatology." — Stephen Mackenzie, M.D. "The introduction of explanatory wood-cuts in the text is a novel and most important feature which greatly furthers the easier understanding of the excellent plates, than which nothing, we venture to say, has been seen better in point of correctness, beauty, and general merit." — New York Medical Journal. PRYOR— PELVIC INFLAMMATIONS. The Treatment of Pelvic Inflammations through the Vagina. By VV. R. Pryor, M.D., Professor of (gynecology in New York Poly- clinic. i2mo, 248 pages, handsomely illustrated. Cloth, $2.00 net. "This subject, which has recently been so thoroughly canvassed in high gynecological circles, is made availai)le in this volume to the general practitioner an<l student. Nothing is too minute f(jr mention and nothing is taken for granted ; coiise(|uently the book is of the utmost value. The illustrations and the techni(juearc beyond criticism." — C/'iicago Medical Recorder. PYE'S BANDAGING. Elementary Bandaging and Surgical Dressing. With Direc- tions concerning the Immediate Treatment of Cases of Emergency. For the use of Dressers and Nurses. By Wamer Pyf, F.R.C.S., late Surgeon to St. Mary's Hospital, London. Small i2mo, with over 80 illustrations. Cloth, flexible covers, 75 cents net. " The directions are clear and the ilhislratioiis .ire good." — /.,'iidon Lancet. " The .-lulhor writes well, tiie diagrams are cle^.r, mikI llie book itself is small and )X)rt- able, although the paper and type are grxxl." — British Medical Journal. RAYMOND'S PHYSIOLOGY. A Manual of Physiology. P,y Joseph II. R.w.mond. .A.M., M.D., Professor of I'hysiology and Hygiene and Lecturer on (gynecology in the Long Island College H()S|jital ; Director of Physiology in the Hoagland Laboratory, etc. 3.S2 pages, with 102 illustrations in the text, and 4 full-page cc^lored plates, ("loth, ;>i.25 net. " F.xiremely well gotten up, and the il lust rat ion>< have been sclcctid with rate. The text is fully abre.Tst with modern jihysiology." — /hiti<.h Medical /ournal. (AUNDERS' Question Arranged in Question and Answer Form. npHE MOST COMPLETE AND BEST ^oi^TTTDrrivrr^c illustrated series of Vi^L/lVJJrJlliNlJo coMPENDs ever issued. Now the Standard Authorities in Medical Literature . . ♦ . with Students and Prartitioncrs in every City of the United States and Canada. ^<* ^ OVER ^75,000 COPIES SOLD. ^ THE REASON WHY. They are the advance guard of "Student's Helps" — that DO help. They are the leaders in their special line, well and authoritatively written by able men, who, as teachers in the large colleges, know exactly what is wanted by a student preparing for his examinations. The judgment exercised in the selection of authors is fully demonstrated by their professional standing. Chosen from the ranks of Demonstrators, Quiz-masters, and Assistants, most of them have become Professors and Lecturers in their respective colleges. Each book is of convenient size (5x7 inches), containing on an average 250 pages, profusely illustrated, and elegantly printed in clear, readable type, on fine paper. The entire series, numbering twenty-three volumes, has been kept thoroughly revised and enlarged when necessary, many of the books being in their fifth and sixth editions. TO SUM UP. Although there are numerous other Quizzes, Manuals, Aids, etc. in the market, none of them approach the " Blue Series of Question Compends;" and the claim is made for the following points of excellence : 1. Professional distinction and reputation of yjthors. 2. Conciseness, clearness, and soundness of treatment. 3. Quality of illustrations, paper, printing, and binding. Any cf these Compends Tvill be maikd on receipt of price (see next page for List). Saunders^ Question-Gompend Series^ Price, Qoth, $J.OO net per copy, except when otherwise ordered. " Where the work of preparing students' manuals is to end we cannot say, but the Saunders Series, in our opinion, bears off the palm at present."— AVzt/ y'orJk Aledxcal Record. 1. ESSENTIALS OF PHYSIOLOGY. By H. A. Hare, M.D. Fourth edition, revised and enlarged. 2. ESSENTIALS OF SURGERY. By Edward Martin, M. D. Seventh edition, revised, with an Appendix ami a chapter on Appendicitis. 3. ESSENTIALS OF ANATOMY. By Charles B. Nancrede, M.D. Sixth edition, thoroughly revised and enlarged. 4. ESSENTIALS OF MEDICAL CHEMISTRY, ORGANIC AND INORGANIC. By Lawrence Wolff, M.D. Fifth edition, revised. 5. ESSENTIALS OF OBSTETRICS. By W. Easterly Ashton, M.D. Fourth edition, revised and enlarged. 6. ESSENTIALS OF PATHOLOGY AND MORBID ANATOMY. By C. E. Armand Semple, M.D. 7. ESSENTIALS OF MATERIA MEDICA, THERAPEUTICS, AND PRE- SCRIPTION-WRITING. By Henry Morrls, M.D. Fifth edition, revised. 8,9. ESSENTIALS OF PRACTICE OF MEDICINE. By Henry Morris, M.D. An Appendix on Urine Examination. By Lawrence Wolff, M.D. Third edition, enlarged by some 300 Essential Formula;, selected from eminent authorities, by \Vm. M. Powell, M.D. (Double number, $1.50 net.; 10. ESSENTIALS OF GYN/ECOLOGY. By Edwin B. Cragin, M.D. Fourth edition, revised. 11. ESSENTIALS OF DISEASES OF THE SKIN. By Henry W. Stelwagon, M.D. Fourth edition, revised and enlargeii. 12. ESSENTIALS OF MINOR SURGERY, BANDAQiNO, AND VENEREAL DISEASES. By Edward Martin, M.D. .Second ed., revised and enlarged. 13. ESSENTIALS OF LEGAL MEDICINE, TOXICOLOGY, AND HYGIENE. By C. E. Armand Semple, M.D. 14. ESSENTIALS OF DISEASES OF THE EYE, NOSE, AND THROAT. By Edward Jackson, M.D., and E. B. Gleason, M.D. Second ed., revised. 15. ESSENTIALS OF DISEASES OF CHILDREN. By William M. Powell, M. D. Second edition. 16. ESSENTIALS OF EXAMINATION OF URINE. By Lawrence Wolff, M.D. Colored "VoGKL Scale." (75 cents net.) 17. ESSENTIALS OF DIAGNOSIS. By S. Solis Cohen, M.D., and A. A. Eshner, M.D. Second ciiition, iliorouLjhly revised. 18. ESSENTIALS OF PRACTICE OF PHARMACY. By Lucius E. Sayre. Second edition, revised and enlarged. 20. ESSENTIALS OF BACTERIOLOGY. By M. V. Ball, M.D. Third edition, revised. 21. ESSENTIALS OF NERVOUS DISEASES AND INSANITY. By John C. Shaw, NLD. Tliird edition, revised. 22. ESSENTIALS OF MEDICAL PHYSICS. By Fred J. Brockway, M.D. Second o<iiii(>n, revis(<l. 23. ESSENTIALS OF MEDICAL ELECTRICITY. By David D. Stewart, M.D., and I'.DWAKD S. LawkaN( K, NL I ). 24. ESSENTIALS OF DISEASES OF THE EAR. By E. B. Gleason, M.D. •Second edition, revised and greatly eidarged. Famphkt containing specimen pages, etc. sent free upon application. Saunders' New Series of Manuals for Students and Practitioners. * I ^riAT there exists a need for thoroughly reliable hand-books on the leading branches of Medicine and Surgery is a fact amply demonstrated by the favor with which the SAUNDERS NEV SERIES OF MANUALS have been received by medical students and practitioners and by the Medical Press. These manuals are not merely condensations from present literature, but are ably written by well-known authors and practitioners, most of them being teachers in representative American colleges. Each volume is concisely and authoritatively w^ritten and exhaustive in detail, w^ithout being encumbered w^ith the introduction of "cases," which so largely expand the ordinary text-book. These manuals will therefore form an admirable collection of advanced lectures, useful alike to the medical student and the practitioner: to the latter, too busy to search through page after page of elaborate treatises for w^hat he wants to know, they will prove of inestimable value ; to the former they will afford safe guides to the essential points of study. The SAUNDERS NEW SERIES OF MANUALS are conceded to be superior to any similar books now on the market. No other manuals afford so much infor- mation in such a concise and available form. A liberal expenditure has enabled the publisher to render the mechanical portion of the w^orfc w^orthy of the high literary standard attained by these books. Any of these Manuals w^ill be mailed on receipt of price (see next page for List). Saunders^ New Series of Manuals* VOLUMES PUBLISHED. PHYSIOLOGY. By Joseph Howard Raymond, A.M., M.D., Professor of Physiology and Hygiene and Lecturer on Gynecology in the Long Island College Hospital : Director of Physiology in the Hoagland Laboratory, etc. Illustrated. Cloth, $1-25 neu SURGERY, General and Operative.— By John Chalmers DaCosta, M. D., Pro- fessor of Practice of Surgery and Clinical Surgery, Jefferson Medical College, Philadel- phia; Surgeon to the Philadelphia Hospital, etc. Second edition, thoroughly revised and greatly enlarged. Octavo, 91 1 pages, profusely illustrated. Cloth, ;S4.oo net; Half Morocco, 35.00 net. DOSE-BOOK AND MANUAL OF PRESCRIPTION/-WRITING. By E. Q. Thornton, M.D., Demonstrator of Therapeutics, Jefferson Medical College, Phila- delphia. Illustrated. Cloth, $1.25 net. SURGICAL ASEPSIS. By Cari, Beck, M.D., Surgeon to St. Mark's Hospital and to the New York German Poliklinik, etc. Illustrated. Cloth, $1.25 net. MEDICAL JURISPRUDENCE. By Henry C. Chapman, M.D. Professor of Insti- tutes of Medicine and Medical Jurisprudence in the Jefferson Medical College of Phila- delphia. Illustrated. Cloth. $1.50 net. SYPHILIS AND THE VENEREAL DISEASES. By James Nevins Hyde, M.D., Professor of Skin and Venereal Diseases, and Frank H. MoNTOdMERY, M.D., Lecturer on Dcraiatology and Genito-Urin.nry Diseases in Rush Medical College, Chicago. Second edition, thoroughly revised and greatly enlarged. PRACTICE OF MEDICINE. By George Roe Lockwood, M.D., Professor of Practice in the Woman's Medical College of the New York Infirmary; Instructor in Physical Diagnosis in the Medical Department of Columbia College, etc. Illustrated. Cloth, S2.50 net. MANUAL OF ANATOMY. By Irvinc S. Haynks, M.D., Adjunct Professor of Anatomy and DemoriStrator of Anatomy, Medical Department <jf the Ne'v Yorn University, etc. Beautifully illustrated. Cloth, $2.50 net. MANUAL OF OBSTETRICS. By W. A. Newman Dorlano, M.D., Assistant Demonstrator of (Obstetrics, University of Pennsylvania; Chief of Gynecological Dis- pensary, Pennsylvania Hospital, etc. Profusely illustrated. Cloth, 52.50 net. DISEASES OF WOMEN. By J. P.land Sutton, F. R. C. S., Assistant Surgeon to .Middlesex Hospital and .Surgeon to Chelsea Hospital, London; and AkilHiK E. Gii.es, M. D., B. Sc. Lund., }•'.!<. C.S. Liiiii., -Assistant Surgeon to Chelsea Hospital, Lon<lon. Handsomely illustrated. Cloth, $2.50 net. VOLUMES IN PREPARATION. NERVOUS DISEASES. By Charles W. IUrk, M.D., Clinical Professor of Nervous Diseases, Medico Chirurgical tollcge. Pliiladel]iliia ; Pathologist tu the Ortliopa'dic Hospital and Infirmary for Nervous Diseases; Visiting Physician to the St. Joseph Hospital, etc. •»• There will be published in the same series, at short intervals, carefully-prepared workl- on various subjects by prominent specialists. Pamphlet containiug specimen pages, etc sent free upon application. 26 Medical Publications of W. B. Saunders & Co. SAUNDBY'S RENAL AND URINARY DISEASES. Lectures on Renal and Urinary Diseases. By Robert Saundby, M.D. Edin., Fellow of the Royal College of Physicians, London, and of the Royal Medico-Chirurgical Society ; Physician to the General Hospital ; Consulting Physician to the Eye Hospital and to the Hos- pital for Diseases of Women; Professor of Medicine in Mason College, Birmingham, etc. Octavo volume of 434 pages, with numerous illus- trations and 4 colored plates. Cloth, $2.50 net. " The volume makes a favorable impression at once. The style is clear and succinct. We cannot find any part of the subject in which the views expressed are not carefully thought out and fortified by evidence drawn from the most recent sources. The book may be cordially recommended.' ' — British Medical Journal. 5AUNDERS' MEDICAL HAND-ATLASES. For full description of this series, with list of volumes and prices, see page 2. " Lehmann Medicinische Handatlanten belong to that class of books that are too good to be appropriated by any one nation." — yournal of Eye, Ear, and Throat Diseases. '• The appearance of these works marks a new era in illustrated English medical works." — The Canadian Practitioner. SAUNDERS' POCKET MEDICAL FORMULARY. Sixth Edition, Revised. By William M. Powell, M.D., Attending Physician to the Mercer House for Invalid Women at Atlantic City, N. J. Containing 1800 formula selected from the best-known authorities. With an Appen- dix containing Posological Table, Formulae and Doses for Hypo- dermic Medication, Poisons and their Antidotes, Diameters of the Female Pelvis and Foetal Head, Obstetrical Table, Diet List for Various Diseases, Materials and Drugs used in Antiseptic Surgery, Treatment of Asphyxia from Drowning, Surgical Remembrancer, Tables of Incompatibles, Eruptive Fevers, Weights and Measures, etc. Hand- somely bound in flexible morocco, with side index, wallet, and flap. ^1.75 net. "This little book, that can be conveniently carried in the pocket, contains an immense amount of material. It is very useful, and, as the name of the author of each prescription is given, is unusually reliable." — Aledical J^ecord, New York. SAYRE'S PHARMACY. Second Edition, Revised. Essentials of tlie Practice of Pharmacy. By Lucius E. Sayre, M.D., Professor of Pharmacy and Materia Medica in the University of Kansas. Crown octavo, 200 pages. Cloth, $1.00 net; interleavec for notes, S1.25 net. [See Saunders^ Question- Co?npe?ids, page 21.] " The topics are treated in a simple, practical manner, and the work forms a very useful Student's manual." — Boston Aledical and Surgical Journal. SCUDDER'S FRACTURES. The Treatment of Fractures. By Chas. L. Scudder, M.D., As- sistant in Clinical and Operative Surgery, Harvard Medical School. Octavo, 433 pages, with nearly 600 original illustrations. Cloth, S4.50 net. Medical Publications of W. B. Saunders & Co. SEMPLE'S LEGAL MEDICINE, TOXICOLOGY, AND HYGIENE. Essentials of Legal Medicine, Toxicology, and Hygiene. By C. E. Armand Semple, B. A., M. B. Cantab., M. R. C. P. Lond., Physician to the Northeastern Hospital for Children, Hackney, etc. Crown octavo, 212 pages; 130 ilhistrations. Cloth, $1.00 net; inter- leaved for notes, $1.25 net. [See Saunders' Quesiion-Co7npends, page 21.] " No general practitioner or student can afford to l^e without this valuable work. The subjects are dealt with by a masterly hand." — London Hospital Gazette. SEMPLE'S PATHOLOGY AND MORBID ANATOMY. Essentials of Pathology and Morbid Anatomy. By C. E. Armand Semple, B.A., M.B. Cantab., M.R.C.P. Lond., Physician to the Northeastern Hos])ital for Children, Hackney, etc. Crown octavo, i 74 pages; illustrated. Cloth, $1.00 net; interleaved for notes, $1.25 n''t. [See Saunders' Question- Compends, page 21.] " Should take its place among the standard volumes on the bookshelf of both student and practitioner." — London Hospital Gazette. SENN'S GENITO-URINARY TUBERCULOSIS. Tuberculosis of the Genito-Urinary Organs, Male and Female. By NiCHOL.AS Senn, ^LD., Ph.D., LL.D., Professor of the Practice of Surgery and of Clinical Surgery, Rush Medical College, Chicago. Handsome octavo volume of 320 pages, illustrated. Cloth, $3.00 net. " An important book u|)on an important suliject, and written by a man of mature judg- ment and wide experience. The author has given us an instructive book upon one of the most im|X)rtarit subjects of the day." — Clinical Reporter. " A work which adds another to the many obligations the profession owes the talented author." — Chicago Medical Recorder. SENN'S SYLLABUS OF SURGERY. A Syllabus of Lectures on the Practice of Surgery, arranged in conformity with " An American Text-Book of Surgery." By Nicholas Skkx, M. I)., Ph.D., Professor of the Prat tice of Surgery and of Clinical Surgery, Rush Medical College, Chicago. Cloth, $1.50 net. "This syllabus will lie found of service by the teacher as well as the student, the work being superbly flone. There is no praise too hii^h lor it. >i'<^ surgeon slioui<l be witbom it." — Ne7v York Medical Times. SENN'S TUMORS. Second Edition, Revised. Pathology and Surgical Treatment of Tumors. Uy N. Sinn, .\I.l), I'll.!)., LI,.D., I'rok-sx)!' of Surgery and of (iiiiical Surgery, kti^ii Medical College: {'roli-s^or of Surger\, (hicago Polyclinic; Attending .Surgeon to l'resl)\ terian llo.s|)itai: .Surgeon-in-( 'hief. St. Joseph's Hospital, Chicago. Srroid h'.,/itioii, 7'/i(>r(>U[;/i/\ A'li'isrd. < )c- tavo volume (jf 718 pages, with 478 ilhistrations. in< hiding i .; full-page plates in colore. . I'ric e> : (loth, j;^.oo net : Half .Moicxco. >6.oo lui. " 'i he mtjst exhaustive of any rccciU Ixnik in Mngii^h on this suliject. It is well illus- trated, and will doubtless remain as the principal ni'iMO},'raph on tiie siii)ie(t in our language ♦^or some years The l.<><«k i> haiuisoniely illustrated and printed, and llie aiidior ha-, given ., notable and lasting contribution to surgery." — Journal 0/ the .■Iniriiurn .Mr,li,<i! Association. 28 Medical Publications of W. B, Saunders & Co. SHAW'S NERVOUS DISEASES AND INSANITY. Third Edition, Revised. Essentials of Nervous Diseases and Insanity. By John C. Shaw, M.D., Clinical Professor of Diseases of the Mind and Nervous System, Long Island College Hospital Medical School ; Consulting Neurologist to St. Catherine's Hospital and to the Long Island College Hospital. Crown octavo, i86 pages; 48 original illustrations. Cloth, $1.00 net ; interlea\ed for notes, Si. 2 5 net. [See Saunders' Question- Competids, page 21.] "Clearly ami intelligently written."' — Boston Medical and Surgical Journal. "There is a mass of valuable material crowded into this small compasi.' — American Medico- Surgical Bulletin. STARR'S DIETS FOR INFANTS AND CHILDREN. Diets for Infants and Children in Health and in Disease. By Louis Starr, M.D., Editor of ''An American Text-Book of the Diseases of Children." 230 blanks (pocket-book size), perforated and neatly bound in flexible morocco. $1.25 net. The first series of blanks are prepared for the first seven months of infant life ; each blank indicates the ingredients, but not the quantities, of the food, the latter directions being left for the physician. After the seventh month, modifications being less necessary, the diet lists are printed in full. P'ormulse for the preparation of diluents and foods are appended. STELWAGON'S DISEASES OF THE SKIN. Fourth Ed., Revised. Essentials of Diseases of the Skin. By Henry W. Stelwagon, M.D., Clinical Professor of Dermatology in the Jefferson Medical College, Philadelphia ; Dermatologist to the Philadelphia Hospital ; Physician to the Skin Department of the Howard Hospital, etc. Crown octavo, 276 pages; 88 illustrations. Cloth, $1.00 net; inter- leaved for notes, $1.25 net. [See Saunders' Question- Compends, page 21.] " The best student's manual on skin diseases we have yet seen." — Times and Register. STENGEL'S PATHOLOGY. Second Edition. A Text-Book of Pathology. By Alfred Stengel, M.D., Professor of Clinical Medicine in the University of Pennsylvania : Physician to the Philadelphia Hospital ; Physician to the Children's Hospital, etc. Handsome octavo volume of 848 pages, with nearly 400 illustrations, many of them in colors. Cloth, §4.00 net; Half Morocco, $5.00 net. STEVENS' MATERIA MEDICA AND THERAPEUTICS. Second Edition, Revised. A Manual of Materia Medica and Therapeutics. By A. A. Stevens, A.M., M.D., Lecturer on Terminology and Instructor in Physical Diagnosis in the University of Pennsylvania ; Professor of Pathology in the Woman's Medical College of' Pennsylvania. Post- octavo, 445 pages. Flexible leather, $2.00 net. " The author has faithfully presented modern therapeutics in a comprehensive work, and, while intended particularly for the use of students, it will be found a reliable guide and sufficiently comprehensive for the physician in practice." — University Medical Magazine. Medical Publications of W. B. Saunders <& Co. 29 5TEVENS' PRACTICE OF MEDICINE. Fifth Edition, Revised. A Manual of the Practice of Medicine. By A. A. Stevens, A. M., M. D., Lecturer on Terminology and Instructor in Physical Diagnosis in the University of Pennsylvania; Professor of Pathology in the Woman's Medical College of Pennsylvania. Specially intended for students preparing for graduation and hospital examinations. Post- octavo, 519 pages; illustrated. Flexible leather, $2.00 net. " The frequency with which new editions of this manual are demanded bespeaks its popularity. It is an excellent condensation of the essentials of medical practice for the student, and may be found also an excellent reminder for the busy physician." — BuffaU Medical Journal. STEWART'S PHYSIOLOGY. Third Edition, Revised. A Manual of Physiology, with Practical Exercises. For Students and Practitioners. By G. N. Stewart, M.A., M.D., D.Sc, lately Examiner in Physiology, University of Aberdeen, and of the New Museums, Cambridge University ; Professor of Physiology in the Western Reserve University, Cleveland, Ohio. Octavo volume of 848 pages; 300 illustrations in the text, and 5 colored plates. Cloth, $3.75 net. " It will majce its way by sheer force of merit, and amply deserves to do so. It is one of the very test English text-books on the subject." — London Lancet. "Of the many text-books of physiology published, we do not know of one that so nearly comes up to the ideal as does Prof. Stewart's volume." — British ALedical Journal. STEWART AND LAWRANCE'S MEDICAL ELECTRICITY. Essentials of Medical Electricity. By D. D. Stewart, M.D., Demonstrator of Diseases of the Nervous System and Chief of the Neurological Clinic in the Jefferson Medical College; and E. S. Lawr.ance, M.D., Chief of the Electrical Clinic and Assistant Demon- strator of Diseases of the Nervous System in the Jefferson Medical College, etc. Crown octavo, 158 pages; 65 illustrations. Cloth, $1.00 net; interleaved for notes, 51-25 net. [See Saunders' Question- Compends, page 21.] " Throughout the whole brief s])ace at their command the authors show a discriminating knowledge of their subject." — Medical A'euis. STONEY'S NURSING. Second Edition, Revised. Practical Points in Nursing. For Nurses in Private Practice. By l->Mii-V A. M. SioNKV, Oraduateof the Training-School for Nurses, Lawrence, Ma.ss.; late Superintendent of the Training-School for Nurses, Carney Hospital, Soutli Boston, Mass. 456 Images, illustrated witli 73 engravings in the text, and 8 colored and half-tone plates. Clotli, $1.75 net. " Tlit^re are few books intended for noti-professional readers which can be so cordially endorsed by a medical journal as can this one." — Tlnrapeutic Gazette. " 'i'liis is a wcllwrilten, ciniiiciitly practical volume, which covers the entire range of private nursing as distinguished f'oin hospital nursing, and instructs the nurse how best to iniM-t tile various emergencies wliicli may arise, and how to jirepare everything ordinarily needed in tiie illness of her patient.'' — .hnerican Journal of Obstetrics and Diseases of lt\ii/ien and Children. " It is a wcjrk that the plivsic Ian can pl.ice in the hands of his private nurses willi tlif assr,ran<e of benelit." — Ohio Medical Journal. 30 Medical Publications of W. B. Saunders & Co. STONEY'S MATERIA MEDICA FOR NURSES Materia Medica for Nurses. By Emily A. M. Stoney, Graduate of the Training-School for Nurses, Lawrence, Mass. ; late Superintendent of the Training-School for Nurses, Carney Hospital, South Boston, Mass. Handsome octavo volume of 306 pages. Cloth, $1.50 net. The present book differs from other similar works in several features, all of which are intended to render it more practical and generally useful. The general plan of the contents tollows the lines laid down in training-schools for nurses, but the book contains much use- ful matter not usually included in works of this character, such as Poison-emergencies, Ready Dose-list, Weights and Measures, etc., as well as a Glossary, defining all the terms used in Materia Medica, and describing all the latest drugs and remedies, which have been generally neglected by other books of the kind. SUTTON AND GILES' DISEASES OF WOMEN. Diseases of Women. By J. Bland Sutton, F.R.C.S., Assistant Surgeon to Middlesex Hospital, and Surgeon to Chelsea Hospital, London ; and Arthur E. Giles, M.D., B.Sc. Lond. , F.R.C.S. Edin., Assistant Surgeon to Chelsea Hospital, London. 436 pages, hand- somely illustrated. Cloth, ;^2.5o net. "The text has been carefully prepared. Nothing essential has been omitted, and its teachings are those recommended by the leading authorities of the day." — Journal of the American Medical Association. THOMAS'S DIET LISTS. Second Edition, Revised. Diet Lists and Sick=Room Dietary. By Jerome B. Thomas, M.D., Visiting Physician to the Home for Friendless Women and Children and to the Newsboys' Home ; Assistant Visiting Physician to the Kings County Hospital. Cloth, $1.25 net. Send for sample sheet. THORNTON'S DOSE-BOOK AND PRESCRIPTION-WRITING. Dose-Book and Manual of Prescription=Writing. By E. Q. Thornton, M.D., Demonstrator of Therapeutics, Jefferson Medical College, Philadelphia. 334 pages, illustrated. Cloth, $1.25 net. "Full of practical suggestions; will take its place in the front rank of works of this >ort. " — Medical Record, New York. VAN VALZAH AND NISBET'S DISEASES OF THE STOMACH. Diseases of the Stomach. By William W. Van Valzah, M.D., Professor of General Medicine and Diseases of the Digestive System and the Blood, New Vork Polyclinic; and J. Douglas Nisbet, M.D., Adjunct Professor of General Medicine and Diseases of the Digestive System and the Blood, New York Polyclinic. Octavo volume of 674 pages, ilhistrated. Cloth, $3.50 net. " Its chief claim lies in its clearness and general adaptability to the practical needs of the general i>ractitioner or student. In these relations it is probably the best of the recent sjjecial works on diseases of the stomach." — Chicago Clinical Review. VECKI'S SEXUAL IMPOTENCE. The Pathology and Treatment of Sexual Impoter.ce. By Victor G. Vecki, MT). From the second German edition, revised and en- larged. Demi-octavo, 291 pages, (^loth, $2.00 net. The subject of impotence has seldom been treated in this country in the truly scientific ST'.rit that it deserves. Dr. Vecki's work has long been favorably known, and the German 000k has received the highest consideration. This edition is more than a mere translation, »or, although based on the German edition, it has been entirely rewritten in English. Medical Publications of W. B. Saunders & Co. VIERORDT'S MEDICAL DIAGNOSIS. Fourth Edition, Revised. Medical Diagnosis. By Dr. Oswald Vierord r, Professor of Medi- cine at the University of Heidelberg. Translated, with additions, from the fifth enlarged German edition, with the author's permission, by Francis H. Stuart, A. M., M. D. Handsome royal octavo volume of 603 pages; 194 fine wood-cuts in text, many of them in colors. Cloth, ;^4.oo net ; Sheep or Half Morocco, $5.00 net. " Rarely is a book published with which a reviewer can find so little fault as with the volume before us. Each particular item in tlie consideration of an organ or apparatus, which is necessary to determine a diagnosis of any disease of that organ, is mentioned ; nothing seems forgotten. The chapters on diseases of the circulatory and digestive apparatus and nervous system are especially full and valuable. The reviewer would repeat that the book is one of the best — probably //<«■ dest — which has fallen into his hands." — University Aledical Magazine. WATSON'S HANDBOOK FOR NURSES. A Handbook for Nurses. By J. K. Watson, M.D., Edin. Ameri- can Edition, under supervision of A. A. Stevens, A.M., M.D., Lecturer on Physical Diagnosis, University of Pennsylvania. i2mo, 413 pages, 73 illustrations. Cloth, S^-So net. WARREN'S SURGICAL PATHOLOGY. Second Edition. Surgical Pathology and Therapeutics. By John Collins Warren, M.D., LL.D., I'rofessor of Surgery, Harvard Medical School. Hand- some octavo, 832 pages ; 136 relief and lithographic illustrations, t^Z iri colors ; with an Appendix on Scientific Aids to Surgical Diagnosis, and a series of articles on Regional Bacteriology. Cloth, $5.00 net; Half Morocco, $6.00 net. " A most striking and very excellent feature of this book is its illustrations. Without exception, from the point of accuracy and artistic merit, they are the best ever seen in a work of this kind. Many of those representing microscopic pictures are so perfect in their coloring and detail as almost to give the beholder the impression that he is looking down the barrel of a microscope at a well -mounted section.'' — Annals of Surgery. WOLFF ON EXAMINATION OF URINE. Essentials of Examination of Urine. By Lawrence Wolff, M.D., Demonstrator of Chemistry, Jefferson Medical College, Philadelphia, etc. Colored (Vogel) urine scale and numerous illustrations. Crown octavo. Cloth, 75 cents net. [See Saunders' Question- Compctuis, page 21.] " A very gf>o(l work of its kind— very well suited to its i)urpose."' — Times and Register. WOLFF'S MEDICAL CHEMISTRY. Fifth Edition, Revised. Essentials of Medical Chemistry, Organic and Inorganic. ("ontaining also Questions on Medical Physics, Chemical I'hysiology, Analytical I'rocesses, Urinalysis, and Toxicology. By Lawrence Wolff, .\LD., Demonstrator of Chemistry; Jefferson Medical College, Philadelphia, etc. C!rovvn octavo, 222 pages. Cloth, i^i.oo net; iiilcr- leavcd for notes, ^1.25 net. [See Saunders' Question- Comprnds, page 21.] •'The scoi>e of this work is certainly equal to that of the l)C>.t course of lectures on Medical Chemistry.'' — I'harmaceutidil Era. CLASSIFIED LIST OK THK Medical Publications OF W. B. SAUNDERS & COMPANY, 925 "Walnut Street, Philadelphia. ANATOMY, EMBRYOLOGY, HISTOLOGY. Clarkson — A Text-Book of Histology, 1 1 Kaynes — A Manual of Anatomy, ... 15 Heisler — A Text- Book of Embryology, 15 Nancrede — Essentials of Anatomy, . . 20 Nancrede — Essentials of Anatomy and Manual of Practical Dissection, ... 20 Semple — Essentials of Pathology, . . 27 BACTERIOLOGY. Ball — Essentials of Bacteriology, ... 8 Crookshank — A Text-Book of Bacteri- ology, 12 Frothingham — Laboratory Guide, . . 13 Levy and Klemperer's Clinical Bacte- riology, 17 Mallory and Wright — Pathological Technique, 18 McFarland — Pathogenic Bacteria, . . ig CHARTS, DIET-LISTS, ETC. Griffith— Infant's Weight Chart, ... 14 Hart — Diet in Sickness and in Health, . 15 Keen — Operation Blank, 17 Laine — Temperature Chart. . . .17 Meigs — Feeding in Early Infancy, . . 19 Starr — Diets for Infants and Children, . 28 Thomas— Diet-Lists 3° CHEMISTRY AND PHYSICS. Brockway — Essentials of Medical Phys- ics, 9 Wolff — Essentials of Medical Chemistry, 31 CHILDREN. An American Text-Book of Diseases of Children, . . 5 Griffith — Care of the Baby, 14 Griffith — Infant's Weight Chart, ... 14 Meigs — Feeding in Early Infancy, . . 19 Powell — Essentials of Dis. of Children, 21 Starr — Diets for Infants and Children, . 28 DIAGNOSIS. Cohen and Eshner —Essentials of Di- agno.-jis, II Corwin — Physical Diagnosis, .... 11 Macdonald — Surgical Diagnosis and Treatment, 18 Vierordt — Medical Diagnosis, .... 31 DICTIONARIES. Borland — Pocket DicticMiary, .... 12 Keating — I 'renouncing Dictionary, . . 16 Morten — Nurse's Dictionary, .... 20 EYE, EAR, NOSE, AND THROAT. An American Text- Book of Diseases of the Eye, Ear, Nose, and Throat, . 5 De Schweinitz — Diseases of the Eye, . 12 Gleason — Essentials of Dis. of the Ear, 13 Jackson — Manual of Diseases of Eye, . 16 Jackson and Gleason — Essentials of Diseases of the Eye, Nose, and Throat, 16 Kyle — Diseases of the Nose and Throat, 17 QENITO=URINARY. An American Text-Book of Genito- urinary and Skin Diseases, 6 Hyde and Montgomery — Syphilis and the Venereal Diseases, 15 Martin — Essentials of Minor Surgery, Bandaging, and Venereal Diseases, . iS Saundby — Renal and Urinary Diseases, 26 Senn — Genito-Urinary Tuberculosis, . 27 Vecki — Sexual Impotence, 30 GYNECOLOGY. American Text- Book of Gynecology, 6 Cragin — Essentials of Gynecology, . . Ii Garrigues — Diseases of Women, ... 13 Long — Syllabus of Gynecology, ... 17 Penrose — Diseases of Women, .... 20 Pryor — Pelvic Inflammations, .... 34 Sutton and Giles — Diseases of Women, 30 MATERIA MEDICA, PHARMACOL- OGY, AND THERAPEUTICS. An American Text-Book of Applied Therapeutics, .... 5 Butler — Text-Book of Materia Medica, Therapeutics and Pharmacology, . . . 10 Cerna — Notes on the Newer Remedies, 10 Griffin — Materia Med. and Therapeutics, 14 Morris — Essentials of Materia Medica and Therapeutics, . . 19 Saunders' Pocket Medical Formulary, 26 Sayre— Essentials of Pharmacy, ... 26 Stevens — E.ssentials of Materia Medica and Therapeutics, 28 Stoney — Materia Medica for Nurses, . . 30 Thornton — Dose-Book and Manual of Prescription-Writing, 30 MEDICAL JURISPRUDENCE AND TOXICOLOGY. Chapman — Medical Jurisprudence and Toxic(jlogy, ... .... 10 Semple — Essentials of Legal Medicine, Toxicology, and Hygiene, 27 Medical Publications of W. B. Saunders & Co. 33 NERVOUS AND MENTAL DISEASES, ETC. Burr — Nervous Diseases, 9 Cbapin — Compendium of Insanity, . . 10 Church and Peterson — Nervous and Mental Diseases, 10 Shaw — Essentials of Nervous Diseases and Insanity, 28 NURSING. Griffith— The Care of the Baby, ... 14 Hampton — Nursing, 14 Hart — Diet in Sickness and in Health, 15 Meigs — deeding in Early Infancy, . . I9 Morten — Nurse's Dictionary, .... 20 Stoney — Materia Medica for Nurses, . . 30 Stoney — Practical Points in Nursing, . 29 Watson — Handbook for Nurses, ... xi OBSTETRICS. An American Text-Book of Obstetrics, Ashton — E.ssentials of 01)stetrics, . Boisliniere — (_)l>stetric Accidents, . Dorland — Manual of Obstetrics, . Hirst — Text-Book of Obstetrics, . Norris — Syllabus of Obstetrics, . . PATHOLOGY. An American Text-Book of Pathology, Mallory and Wright — Pathological Technique, Semple — Essentials of Pathology and Morbid Anatomy, Senn — Pathology and Surgical Treat- ment of Tumors, Stengel — Text- Book of Pathology, . . Warren — Surgical Pathology and Thera- peutics, PHYSIOLOGY. An American Text-Book of Physi- ology, Hare — Essentials of Physiology, . . . Raymond — Manual of Physiologfy, . . Stewart — Manual of Physiology, . . . PRACTICE OF MEDICINE. An American Text-Book of (he The- ory and Practice of Medicine An American Year-Book of Medicine and Surgery, Anders — Text-Book of the Practice of Medicine, , Lockwood — Manual of the Practice of Medicine, Morris — Essentials of the Practice of Medicine, . Stevens — Manual of the Practice of Medicine, SKIN AND VENEREAL. An American Text-Book (;f (ienito- Urinaryand .Skin Diseases Hyde and Montgomery — .Syphilis and the \ encreal HistMses, 15 20 31 Martin — Essentials of Minor Surgery, Bandaging, and Venereal Diseases, . 18 Pringle— Pictorial Atlas of Skin Dis- eases and Syphilitic Affections, ... 21 Stelwagon — Essentials of Diseases of the Skin, 28 SURGERY. An American Text- Book of Surgery, 7 An American Year-Book of Medicine and Surgery, 8 Beck — Fractures 9 Beck — Manual of Surgical .Asepsis, . . 9 DaCosta — Manual of Surgery, . ... 12 International Text-Book of Surgery, . 15 Keen— Operation Blank, 17 Keen — The Surgical Complications and Sequels of Typhoid Fever, 17 Macdonald — Surgical Diagnosis and Treatment, 18 Martin — Essentials of Minor Surgery, Bandaging, and Venereal Diseases, . 18 Martin— Essentials of Surgery, .... 18 Moore — Orthopedic Surgery, 19 Nancrede' — Principles of Surgery, . . 20 Pye — Bandaging and .Surgical Dressing, 21 Scudder — Treatment of Fractures, . . 26 Senn — ( ienito-Urinary Tuberculosis, . 27 Senn — .Syllabus of Surgery, 27 Senn — Pathology and Surgical Treat- ment of Tumors, 27 Warren — Surgical Pathology and Ther- apeutics, 31 URINE AND URINARY DISEASES. Saundby — Renal and Urinary Diseases, 26 Wolff — Essentials of Examination of Urine, 31 MISCELLANEOUS. Abbott — Hygiene of Transmissible Dis- eases, 8 Bastin — Laboratory Exercises in Bot- any, 9 Gould and Pyle — .Anomalies and Curi- osities of Medicine 13 Grafstrom — Massage, ....... 14 Keating — How to Examine for Life Iiisur;ince „ . . 16 Rowland and Hedley — .Archives of the kocnIgiM Kay, 21 Saunders' Medical lland-.Atlases, .2, 3, 4 Saunders' New Series of Manuals, 24, 25 Saunders' I'ocket Medical lornnilary, 26 Saunders' ( hu-stion-Compends, . . 22, 23 Senn — Pathology and Surgical Treat- ment of Tumors, 27 Stewart and Lawrance — Essentials of Medical Electricity 29 Thornton — I)ose-l'ook and Manual of Pns(ri])tion Writing, . 30 Van Valzah and Nisbet — Diseases of the Stomach 3" BOOKS JUST ISSUED. THE AMERICAN ILLUSTRATED MEDICAL DICTIONARY. For Students and Practitioners. A Complete Dictionary of the Terms used in Medi- cine and the Allied Sciences, with a large number of Valuable Tables and Numerous Handsome Illustrations. Edited by W. A. Newman Borland, M. D., Editor of the American Pocket Medical Dictionary. Handsome large octavo, 800 pages, bound in full limp leather, and printed on thin paper of the finest quality, forming a handy volume, only i '4 inches thick. This is an entirely new and unique work, intended to meet the need of practitioners and students for a complete, up-to-date dictionary of moderate price. The book is designed to furnish a maximum amount of matter in a minimum space and at the lowest possible cost. It contains double the material in the ordinary students' dictionary, and yet, by the use of a clear, condensed type and thin paper of the finest quality, is only 1% inches in thickness. It is bound in full flexible leather, and is just the kind of a book that a man will want to keep on his desk for constant reference. The book makes a special feature of the newer words, and defines hundreds of important terms not to be found in any other dictionary. It is especially full in the matter of tables, containing more than a hundred of great practical value. A new feature is the inclusion of numerous handsome illustrations, many of them in colors, drawn and engraved specially for this book. These have been chosen with great care and add infinitely to the value of the work. The book will appeal to both practitioners and students, since, besides a complete vocabulary, it gives to the more important subjects extended consideration of an encyclopedic character. BOHM, DAVIDOFF, AND HUBER'S HISTOLOGY. A Text=Book of Human Histology. Including Microscopic Technic. By Dr. A. A. B;mM and Dr. M. vom Davidoff, of Munich, and G. C. Hubkr, M. D., Junior Professor of Anatomy and Histology, University of Michigan. FRIEDRICH AND CURTIS ON THE NOSE, THROAT, AND EAR. Rhinology, Laryngology, and Otology in their Relations to General Medicine. By Dr. E. P. Friedrich, of the University of Leipsig. Edited by H. Holbrook Curtis, M. D., Consulting Surgeon to the New York Nose and Throat Hospital. LEROY'S HISTOLOGY. The Essentials of Histology. By I,oitis Eeroy, M.D., Professor of Histology and Pathology, Vanderbilt University, Nashville, Tennessee. OQDEN ON THE URINE. Clinical Examination of the Urine. By J. Bergen Ogden, M. D., Assistant in Cliemistry, Harvard Medical School. Handsome octavo volume of over 408 pages, with 54 illustrations and I I full-page plates, many in colors. PYLE'S PERSONAL HYGIENE. A Manual of Personal Hygiene. Edited by Walter E. Pyle, M. D., Assist- ant Surgeon to Wills Eye Hospital, Philadelphia. Octavo volume of 344 pages, fully illustrated. SALINGER AND KALTEYER'S MODERN MEDICINE. Modern Medicine. By Tui.ius L. Salinger, M. D., Demonstrator of Clinical Medicine, Jefferson Medical College, and E. J. Kalteyer, M. I )., Assistant Demon- strator of C'linical Medicine, Jefferson Medical College. Handsome octavo volume of over 800 ])ages, fully illustrated. STONEY'S SURGICAL TECHNIC FOR NURSES. Surgical Technic for Nurses. liy Emily A. M. Stoney, late Superintendent of tile Trainiiig-School for Nurses, Carney Hospital, South Boston, Massachusetts. THE AMERICAN POCKET MEDICAL DICTIONARY. Edited by W. A. Newman Dorland, A.M., 2^D., Assistant Obstetrician to the Hospital of the University of Penn- AMERICAN POCKET MEDICAL DICTIONARY sylvania; Fellow of the American Academy of Medicine, etc. Over 500 pages. Full leather, limp, with gold edges. Price, $ J. 00 net; with patent thumb index, $J.25 net. THIRD EDITION, REVISED. This is the ideal pocket lexicon. — It is an absolutely new^ book, and not a revision of any old work. — It is complete, defining all the terms of modern medicine, and forming an unusually full vocabulary. — It gives the pronunciation of all the terms. — It makes a "One of the handiest lit le dictionaries for the pocket that we have ever seen. Its definitions are short, concise, and complete, so that it contains within a small space as many words, satisfactorily defined, as are found in some of the much larger volumes." — American Medico-Swgicul Bulletin. special feature of the new^er w^ords neglected by other dictionaries. — It contains a wealth of anatomical tables of special value to students in preparing for examinations. — The new^ or "reformed" spelling is employed. — A handy volume indispensable to every medical man. J* For sale by all Booksellers, or sent post-paid on receipt of price. W. B. SAUNDERS & CO., Publishers, 925 Walnut St., Philadelphia. CLINICAL EXAMINATION OF THE URINE AND URINARY DIAGNOSIS. A OGDEN ON Clinical Guide for the THE URINE Use of Practitioners and Students of Med- icine and Surgery. By J. Berg^en Ogfden^ M.D., Instructor in Chemistry, Harvard University Medical School; Assistant in Clinical Pathology, Boston City Hospital. Handsome octavo, 425 pages, with 54 illustrations, and a number of colored plates. Cloth, $3.00 net. JUST ISSUED. The design of this work is to present in as con- cise a manner as possible the chemistry of the urine and its relation to physiologic processes; the most approved working methods, both quali- tative and quantitative ; the diagnosis of diseases and disturbances of the kidneys and urinary passages. jIt jA ^ .^'t ^ jl jl jft j)t In addition to chemic and microscopic methods, w^hich have been described in detail, special attention has been paid to diagnosis, including our present knowledge of the character of the urine, the diagnosis and differentiation of dis- eases of the kidneys and urinary passages ; an enumeration of the prominent clinical symptoms of each disease; and, finally, the peculiarities of the urine in certain general diseases of the body. For sale by all Booksellers, or sent post-paid on receipt of price. W. B. SAUNDERS & CO., Publishers, 925 Walnut St., Philadelphia. Kb / 01 IROO THE LIBRARY UNIVERSITY OF CALIFORNIA Santa Barbara THIS BOOK IS DUE ON THE LAST DATE STAMPED BELOW. Series 9482 i£SOm>jERNREGIONAL LIBRARY FACILITY A A 000 146579 I