y ml 0«^ ^OFCAUFOM^ 1*1 IMf m^^ %a3AiNii-3y^^ i'?' r^ §1 irri ^JJimSOl'^ ^JQAJWUVJt '^OTJVSOl^ '^WAINn^V^ ^tUBRARYOc -s^^^UBRARYO^ ^OFCAUFOR^ ^ s %0JI1V}J0'^ ^OFCAUFORj^ 4MEUNIVER% ^lOSAKCFl^^ ^^QNVSOl'*^ ^5XIEUNIVER%. ■^aaAwniviv^ ^lOSANCn% !3 :3 _ "^/saaMNn-ivr [RS/A A>:lOSANCEl% 4AlllBRARYac^ ^^lUBRARYQc^ Fl (lE Wit itf ^^ ?-1 eo =3 I' i'^ %ojnwjo'^ <o»/3or AttoXXcuv Sophocles, in the CEdipus Coloneus, re- Ess. VI.] OF ARET.EUS. 97 presents (Edipus, as lie is walking to the spot where he is to die, foretelling to Theseus the prosperity of Athens, and of his family. Eyw ^t^x^cj, rex-vov Kiysus, cc aoi Y'npcos aCkvTtoL T-n^E KsiasTxi ttoXej. I long to give the messenger's awful ac- count of the extinction and disappearance of (Edipus immediately afterwards, which Longinus enumerates amongst his instances of the sublime, but I dare not trespass longer on your time. Virgil follows Homer in describing Orodes in the tenth book of the ^Eneid, prophesy- ing the death of Mezentius, by whom he had just been mortally wounded : jacet altus Orodes. Conclamant socii, laetum pseana secuti. Ille autem expirans : Non me, quicunque es, inuU6 Victor, nee longum laetabere : te quoque fata Prospectant paria, atque eadeni mox arva tenebunt. And Shakspeare adopts it in various places, as in Henry IV., where Hotspur, H 98 ox THE KATSOS OF ARET.T.US. [Kss. VI. mortally wounded and about to die imme- diately, says, ' Now could I prophesy — but that the icy hand of death,' &c. And again, in Richard 11., where the dying John of Gaunt exclaims, ' Methinks I am a prophet new inspired !' But I have extended this speculative part of my paper to too great a length ; not that I dread the reproach of those amongst you who delight to mix the elegancies of litera- ture with the severer studies of your pro- fession ; nor do I fear the disapprobation of such as are intent only upon acquiring a knowledge of physic. They will surely thank me for having laid before them so faithful, so beautiful an historian of disease ns Aretceus. 99 ESSAY VII. TREATMENT OF GOUT. So much has been written on the subject which I lay before you this evening-, that I feel as if some apology were necessary for taking up your time with remarks upon the Gout. But I rest assured, that you will receive in good part the result of my long- experience in the treatment of that disease ; and that, if I state to you that there is no malady to which I am called upon to ad- minister, that I prescribe for with so much confidence in the resources of our art, as for Gout, formerly the opprobrium medicorum, you will give me willingly a few moments of your attention. H 2 100 ON THE TREATMENT [Ess. VII. I will not dwell upon the various seats of Gout in the human frame. For though the terms Arthritis and Podagra would seem to limit the malady to the feet and the joints, we have seen it in almost every part of the human system. There are those who believe that they have observed it in the eye. I have certainly seen it in the kidney, in the urethra and prostate gland, and in the ton- sils. One of our esteemed colleagues has suffered it there ; and I remember an emi- nent physician in the country so harassed by it, and so disappointed by finding no effect from the most approved remedies for the Angina Tonsillaris, that at length he plunged a lancet into it ; if, peradventure, there might be some deep-seated suppura- tion there, to which he should give an exit. No matter followed ; but in a few minutes the Gout attacked the ball of his great toe. The Angina was soon forgotten, and the new Ess. VII.] OF GOUT. lOl disease ran its course with all its accustomed severity. With regard to the remedies for Gout, my dependence is placed upon the Colchi- cum. Under the common circumstances of an attack of Gout in the extremities, 1 do not use it immediately, but wait a day or two, until the malady shall have fixed itself. I then direct the wine of the root, prepared according to the directions of the Pharma- copoeia; and I do not hesitate to declare, that I have not known a single instance of any untoward effect from it. It often cures the disease without any manifest increase of any of the excretions. Sometimes it pro- duces perspiration, and sometimes it acts as a diuretic — the two objects aimed at gene- rally by a physician in the use of our com- mon resources in the treatment of this disease ; but so far is it from being prone to purge the body violently, as the Eau M^di- 102 ON THE TREATMENT [Ess. VII. cinale often did, that I find it necessary, in most cases, to combine a small portion of tlie Sulphate of Magnesia with the vAne, in the draught in which I administer it. The formula which I have found most useful is a Saline draught with Camphor mixture, a drachm of Syrup of White Poppies, and from 35 to 45 minims, not more, of the wine of the Root of Colchicum, at bed-time ; to be repeated in the morning with 25 drops only of the wine, and half a drachm of the Syrup of Poppies ; and in this dose a drachm of the Sulphate of Magnesia. It is necessary to repeat these draughts for three or four successive nights and morn- ings, and to follow its use by a piil con- taining three grains of an acetous extract of the Colchicum, (made by evaporating an in- fusion of the root in vinegar,) and one or two grains of the Pulv. Ipecac. Comp., and the same quantity of the Extractum Colocyn- Kss. VII.] OF GO IT. \03 thidis Comp., and to terminate the whole by a mild purgative. It has been objected to the Colchicum that it produces a temporary good effect only, and that the Gout is apt to recur when treated with this medicine after a shorter interval than usual. Be it so for argument's sake — yet surely the weight of three or four attacks of the disease, of three or four days' continuance each, not more, is hardly to be compared with the pressure of a six weeks' painful confinement in the spring, and one of equal duration at the latter end of the year, as was the case before the value of this remedy was known ; the paroxysms, moreover, terminating often by distortion and disfigurement of the joints by chalk stones ; an evil which is now prevented almost universally by that control which the Colchicum puts upon the inflammatory stage of a fit of Gout. But my experience 104 ON THE TREATMENT [Ess. VII will not admit it to be true that the disease returns more quickly. On the contrary, when the liquid preparation has been fol- lowed by the acetous extract, I think I am fully justified in asserting that the disease is removed for as long an interval as usually intervened between the fits, when left, as it was left formerly, to patience and flannel. I am not rash and inconsiderate enough to recommend this mode of treatment to you as a specific system for managing the Gout in all its forms, and under all the circum- stances of different constitutions^ which may present themselves to you. The formula will require to be varied occasionally, and it may be proper in many instances of an enervated state of the frame to reinvigorate it by a light preparation of the Peruvian Bark, after the Colchicum has done its duty — or, in other instances, to give two or three doses of the Pil. Hydrargyri at bed- Ess. VII.] OF GOUT. 105 time every night, in order to recall the bile into its proper channels, if the Colchieum or the Sedative with which it has been com- bined shall have produced ash-coloured evacuations by the bowels, denoting an ob- struction of the bile. Of all the preparations of this valuable medicine I prefer the infusion of the root in Sherry wine. A preparation has been made, and is in frequent use, in the manner of an infusion of the seeds in preference to the root, but this has appeared to me to be apt to create an insupportable nausea ; such an one as I have seen follow Wilson's Tincture for the Gout, and the Eau Medicinale. When such an effect has once followed, it is in vain that you request the patient to have recourse to it again. He will answer you, that he would rather endure his disease in all its severity than subject himself to the misery of such a remedy. This answer I 106 ox THE TREATMENT [Kss. VII. have heard given to a proposal to administer the Digitalis, when it had once affected the stomach in this manner — even when it had in one patient evacuated water from the chest in three successive attacks of Hydro- thorax ; and in another, controlled a danger- ous affection of the heart for several years. No — these patients both declared that they would rather die than swallow one dose of Digitalis more. Before I dismiss the subject of Colchicum, I must add that the use of this vegetable in Gout is by no means jiew ; for it is re- commended by Alexander of Tralles, a city of Lydia, in the sixth century, as a remedy for this disease, not under the name of Col- chicum, indeed, but of Hermodactyls. Now the Hermodactyls and the roots of Col- chicum are the same, as you will observe by a comparison of the specimens on the table. Being anxious to obtain some Her- Kbs. VII.] OF GOUT. 107 modactyls, I availed myself of the good offices of one of the king's messengers, and purchased those before you in the market at Constantinople. They appear to be the same vegetable root as Sir G. Blane has stated on the authority of Sir Joseph Banks : though our estimable colleague, Dr. J, A. Wilson, is of opinion that there is a differ- ence between them. I have not yet infused them in vv^ine, but intend to do so immedi- ately, and to try their efficacy upon Gout in the same manner as I have prescribed the Colchicum. But it is not enough to state what I have found the most easy and effectual method of treating a fit of the Gout, unless at the same time I lay before you the manner by which I attempt to prevent an attack. As to medicine, I have had, incomparably, the most satisfaction in giving a few grains of Rhubarb and double the quantity of the 108 ON THE TREATMENT [Ess. VII. Carbonate of Magnesia every day, either at bed-time or early in the morning ; or, under evident weakness of the powers of digestion, half an ounce of the compound Tincture of Rhubarb with fifteen grains of the Carbon- ate of Potash, in some light bitter infusion, daily, before the principal meal. The coarser purgatives should be carefully avoided ; as I have often known a strong dose of physic, as well as a bleeding, ag- gravate a mere slight indication of Gout into a severe decided fit. But the management of himself and of his habits, on the part of the patient, is of more importance in keeping off this malady than medicine. His diet must be restricted, and he must dine at an earlier hour than is the custom at present amongst the higher ranks of society ; his exercise must be gentle, but regular ; his mind must be kept free from solicitude and care ; he must Ess, VII.] OF GOUT. 109 avoid intense study*, and he must be chaste. The word which Pliny uses to express this item of precaution is a remarkable one, and, as far as I remember at this moment, pecu- liar to himself — it is sanctitas. He remarks of a friend of his, a martyr to the Gout, that ' Pedum dolorem fregit abstinentia, et sanc- titate.' This point of conduct may have been thought important in the eyes of the Roman, in consequence of what Hippocra- tes has remarked in the 30th Aphorism of the 6th Section, relative to the non-appear- ance of Gout before puberty, IlaT^ oo VToZaypicc, Ts^ too a(p^o8!ffT(», but a third kind is mentioned as a useful sedative. Es8. X.] PERSONS OF ANTIQUITY. 153 US suspect, that the Hyoscyamus had been known from very early times as a narcotic. But it is most probable that the poison which was administered to Socrates, was the same as that which was given to other con- demned criminals, and that, we know, was the x(i)vsiov*, the Cicuta, Hemlock. Dion, the father of Dionysius the tyrant of Syra- cuse, who was intimately acquainted with Plato, and therefore a contemporary of So- crates, was poisoned by Hemlock, and Plutarch f says, that Phocion drank the xcoveiov. This, we have reason to suppose, was always fresh pounded for the occasion ; and we learn from Theophrastus,^ that the whole plant was usually pounded together, but that the Chians peeled off the outer rind, as occasioning pain, and that then * See Aristophanes' Ran. 123, quoted by Forster towards tlie end of his notes on the Phsedo. •I" Vide Plutarchum in Vita Phocionis, 6. 37. t Hist. PI. ix. 17. 154 DEATHS OF ILLUSTRIOUS [Ess. X. having bruised the other part, and put it in water, they drank the infusion, and found it to cause an easy death. Juvenal was there- fore correct in speaking of the Cicuta as the poison which Socrates drank. ' Hunc inopem vidistis Athenae Nil praeler gelidas ausse conferre Cicutas.' Whatever the poison were, it must have been one of weak and tardy operation ; for the executioner told Socrates, that it would prevent its effect, if he entered into earnest dispute, and that it was sometimes necessary to repeat the dose three or four times. After a while, the Philosopher is described as having felt a weight in his legs, as if he had been intoxicated. The effect of the drug grew stronger, and made him, at length, so insensible to pain, that he did not feel when his foot was pinched. The ex- tremities grew cold, — he was convulsed, and expired. E8S.X.] PERSONS OF ANTIQUITY. 155 But what was the poison contained in that * Cannarum Vindex, et tanti sanguinis ultor Annulus' by which Hannibal destroyed himself? When the tyrant of Bithynia had pointed out to his enemies who were in pursuit of him, the house in which Hannibal lodged, the unfortunate General, finding his fate inevitable, said, according to Livy, ' Now* will we liberate these Romans from ' their unceasing solicitude about us. They * are tired/ it seems, of waiting for the death ' of an old man,' and took the poison. What it was, it is almost impossible that we should ever know. Modern chemistry, indeed, could furnish twenty poisons capable of being comprehended within the space of a ring. One drop of Prussic acid, contained in a small glass tube open at both ends, and held between the finger and thumb, so as to * Solvamus diuturna cura populum Komanum, qtiando mortem senis expectare longum ceiiset. — Livy. 156 DEATHS OF ILLUSTRIOUS [Ess. X. touch both when in motion, would paralyze the arm almost instantaneously, and, of course_, if taken into the stomach, would forthwith arrest the current of life. But although the Carthaginians were a much more civilized people than their enemies, the Romans (who happen to be their historians), are willing to allow, yet it is too much to suppose, that they knew how to prepare the Prussic acid. No, — Lyhia feraoc venenorum, Lybia abounding in the venom of serpents, and in the inspissated juices of deleterious vegetables more probably furnished them with the poisons in question, and afforded to Hannibal a sure resource whenever his circumstances should become desperate.* As to the report of his being poisoned by * My friend Mr. Hatchett conjectures that the poison which Hannibal took might have been the inspissated exu- dation of the Euphorbia officinalis. The Euphorbia is a native of Africa, abundant there, and was well known as one of the most powerful acrid vegetable poisons. Ess. X.] PERSONS OF ANTIQUITV. 157 drinking bullock's blood, mentioned by Plu- tarch, it must be a fable, as was that also of the death of Themistocles by drinking a similar draught, for the blood of that animal is not poisonous. An accomplished Noble- man told me that he was present at one of the bull-fights at Madrid, when a person rushed from the crowd, and having made his way to the bull which the Matador had just stricken, caught the blood, as it flowed from the wound, in a goblet, and drank it off before the assembly. On inquiring into the object which the poor Spaniard had in view, it appeared that the blood of a bull just slain was a popular remedy for consumptive symptoms. Of the poison by which Nero destroyed Britannic us — I think we may form a proba- ble conjecture, by considering all the circum- stances of the narrative of Tacitus*, taken in * See Annal. Lib. xiii. c. 15. 158 DEATHS OF ILLUSTRIOUS [Ess. X. comparison with the effects of a deleterious distilment made notorious in our days, thi laurel water. The historian states, that when Nero had determined to dispatch the ill-fated youth, he sent for Locusta, a con- victed female poisoner, who had been par- doned, and was kept for state purposes, Nero ordered her to prepare a poison which should produce its effect immediately, in distinction from one of those which should prove fatal at some distant given day ; for the notion prevailed then (as at the begin- ning of the last century, when the aqua topJiana, a solution of Arsenic, was used for these base purposes), that poisoners could devise a draught which would operate at any given period. Locusta prepared one which killed a goat after five hours. This would not serve the tyrant's purpose — he ordered her to provide a more speedy in- strument, to prepare it in his own chamber. Ess. X.] PERSONS OF ANTIQUITY. 159 ^and in his presence. The boiling began, cand was urged to the effectual moment ; in proof of which it was tried on a hog, and the animal was killed by it immediately. Dinner is served. The young members of the Imperial Family are sitting at the foot of the table. The Emperor and his guests re- clining on their sides. The unhappy youth calls for water — the Preegustator tastes it, and then serves it. It is too hot. Some of it is poured off, and the glass is filled up with a fluid resembling water — but this con- tains the poison. The young man drinks it, and is seized instantly with an epileptic fit, in which he expires. He is buried the same night. This detail may recall to the recollection of many of you the case of Sir Theodosius Boughton, who was poisoned by Captain Donellan, in the year 1780, with laurel water. It appeared probable, on the trial, 160 DEATHS OF ILLUSTRIOUS [Ess. X. that the fluid in which the jalap had been mixed as a purgative medicine, and sent by Sir Theodosius Boughton's apothecary, had been poured off, and laurel water substi- tuted in its room. The effect was precisely the same in the two cases ; each of the un- happy victims experienced an epileptic fit which proved fatal immediately. You re- member the testimony of the late Mr. John Hunter, who went down to Warwick to give his opinion respecting the disease of which Sir Theodosius had died, and that he pro- nounced it an epileptic fit. Nero, whilst the poor youth was convulsed and struggling under the workings of the poison, had the audacity to state to his associates at the table, that they need not disquiet themselves, the youth would soon be himself again — that he had been subject to epileptic fits from his infancy ; and Do- nellan, in the same defiance of truth, alleged Ess. X] PERSONS OF ANTIQUITY. IGl that there was no reason for surprise at the sudden death of Sir Theodosius Boughton, as he was subject to fits of this dangerous character. Another circumstance is mentioned by Dio Cassius ; viz., an extraordinary livid- ness* which came over the face of Bri- tannicus, and which Nero was tempted to endeavour to conceal by paint, lest it should betray the secret that he had perished by foul means. Now I remember to have seen the face of Sir Theodosius Boughton, when the corpse had been disinterred, in order to be examined for the satisfaction of * ^iXilm — Does Juvenal allude to this circumstance in his first Satire ? — Instituitque rudes melior Locusta propinquas Per famam, et populura nigros efFerre maritos. If so, by the epithet, nigros, he may l)e fairly supposed to have associated the name of the infamous Locusta, with the appropriate effect of the peculiar poison by which she usually executed her diabolical purposes. M 1G2 DEATHS OF ILLUSTRIOUS [Ess. X. the Coroner's Jury, and its colour resembled that of a pickled walnut. I do not lay much stress upon these circumstances, though they are not without their interest. But if we only suppose that the Romans were acquainted with the deleterious influence of the Laurel, and the process of distilla- tion, we shall find no difiiculty in supposing that Britannicus was poisoned by Laurel Water. It is true that it is the Lauro Cerasus from which we have distilled the Laurel Water, and that the Lauro Cerasus is not indigenous in Italy, but is a native of Col- chis*, and the neighbourhood of the Euxine Sea. But, why may it not have been im- ported trom thence with the Venena Col- chica, of which we read so frequently ? And when we recollect, moreover, that this * The first Laurel brought into this country came from Trebizond. Ess.X.] PERSONS OF ANTIQUITY. 163 Canidia, whom Nero employed, was a con- victed adept in the art of poisoning, it is not difficult to persuade ourselves, that the Lauro Cerasus might have been the mate- rial which Locusta boiled in Nero's presence. The Laurus Nobilis, the Daphne, grows spontaneously about Rome, and was dedi- cated to Apollo^ the God of Physic ; and the enlightened inhabitants of that great city could not fail to have heard of the influence of the Daphne upon the Pythian priestess at the temple of Delphi, the oracle of their Grecian neighbours, centuries before. The priestess, you know, was agitated and con- vulsed before she prophesied^ and these con- vulsions were occasioned by the use of the Daphne,* which she was compelled to take, * Professor Sibthorp, who visited Greece in 1794, thus writes in his manuscript Journal : — ' On the rocks of Del- phi I observed some curious plants; a new species of Daphne, which 1 have called Daphne Castaliensis, af- forded me singular pleasure.' M 2 164 DEATHS OF ILLUSTRIOUS [Ess. X. in some form or other, always to the dan- ger, and frequently to the destruction of her life. As to their knowledge of the art of dis- tillation, it is true, that they had not the still and the refrigeratory, which modern science has brought to such perfection ; but they practised the simpler mode of receiving the vapour of the boiling herbs in a handful of wool, or in a sponge, from which they squeezed it when cold, and kept it for use. This was a ruder mode of obtaining the virtue of herbs ; but nevertheless, not an ineffectual one. Alexander the Great was said to have been poisoned ; but the best account of his death is written by Arrian, who men- tions such a report as having prevailed ; but this, after giving a rational detail of his illness, and also recounting the daily bulle- tins which were issued respecting it, the Ess. X.] PERSONS OF ANTIQUITY. 165 most ancient series of bulletins on record. The story went, that a poison had been sent to him by Antipater* , prepared by Aris- totle, (to his everlasting infamy, had it been true, for the Stagirite had been Alexander's preceptor,) that this poison had been con- veyed in the hoof of a mule, being of so subtle a nature, that no vessel of silver or iron or any other metal could contain it. Plutarch states this, and so does Quintus Curfius, with whom agree Justin and Plinyf". But had it been sent at all, it would not have been conveyed in the hoof of a mule, or of any other beast of burthen, as tlie com- mentators on the foregoing authors amuse themselves with alleging ; but in an onyx, a stone of some value, which was employed to hold precious ointments. We have in * Viceroy of Macedon during Alexanders absence, t Lib. XXX. c. )5. 166 DEATHS OF ILLUSTRIOUS [Ess. X. Horace, "Nardi parvus onyx." Now ovu^ in Greek signifies, not only this stone, but also unguis, the first sense of which is a human nail ; but the second is the hoof of a horse, or mule. The second sense of unguis, therefore, was given by mistake, instead of a precious stone. The late Dr. Heberden (whose memory deserves the peculiar re- spect of our profession, as he was not only a ripe and good scholar, but an excellent physician) unravels the mysterious tale of the custom of professed poisoners, of carry- ing their poisons under their nails^ by this misinterpretation of the word ow^. And the same satisfactory explanation may be applied, I think, to this fable of the imputed atrocity of Antipater. Alexander died, in fact, of a remittent fever, which he had caught in the marshes of Babylon. He had resolved to make that Ess. X] PERSONS OF ANTIQUITY. 167 mother of cities and cradle of civilization the capital of his great eastern empire, and occupied himself, amongst other important objects, with diverting the channel of the Euphrates, and draining some enormous lakes which the river had left from time to time by overflowing its banks. He super- intended these operations himself, and be- gan to complain of fever on the day which he had set apart for offering a splendid sacrifice for the success of his intended ex- pedition to Arabia. After the banquet, he was prevailed upon to spend the evening with Medius, one of his favourites, where he remained till after midnight, not, however, to commit any ex- cess, but for the pleasure of social inter- course, for Arrian says, expressly,* that o) TTOTOi 6s, ou TOO oiuou svsxa, [xaxpol auTco * Vide Arrian de Expedit. Alexandri, lib. 7. Sub tinem. 168 DEATHS OF ILLUSTRIOUS [Kss. X. hyiyvovTO (ou yap ttivsiv TTo'kuv ohov A7\.s^av^^ov) aTO^a &A«vaan# ^lOSANCEl^^ •<»^3NVS01'^ %a3AiN(imv^ %&