med. Lib OS THE LIBRARY OF THE UNIVERSITY OF CALIFORNIA LOS ANGELES A SKETCH EARLY HISTORY OF PRACTICAL ANATOMY. THE INTRODUCTORY ADDRESS TO THE COURSE OF LECTURES ON ANATOMY AT THE PHILADELPHIA SCHOOL OF ANATOMY. TUESDAY, OCTOBER 6, 1874. BY WILLIAM W. KEEN, M.D., Lecturer on Anatomy and Operative Surgery in the Philadelphia School of Anatomy ; Lecturer on Pathological Anatomy in the Jefferson Medical College j Fell6w of the College of Physicians of Philadelphia ; Member of the Academy of Natural Sciences of Philadelphia, etc. etc. PHILADELPHIA: J. B. LIPPINCOTT & CO. 1874. CORRESPONDENCE. W. W. KEEN, M.D. DEAR SIR: The Class of 1874-5 In the Philadelphia School of Anatomy having heard with unfeigned interest your lecture of last even- ing on the " Early History of Practical Anatomy," earnestly solicit a copy for publication. Very respectfully, Your obedient servants, W. W. VAN VALZAH, R. H. MCCARTY, M.D., J. CRAIG MILLER, Committee. PHILADELPHIA, Oct. 7, 1874. Messrs. W. W. VAN VALZAH, R. H. McCARTY, M.D., and J. CRAIG MILLER, Committee. GENTLEMEN : Your note, on behalf of the Class, requesting a copy of my Address for publication, is received, and I accede to your polite re- quest with pleasure. My Address was delivered before the Class of 1870, and published by them, but the edition was very soon exhausted. Since that time I have made a number of corrections and additions, especially to the notes. Hoping that it may lead you to more thorough studies in the History of Anatomy, I remain, gentlemen, Very respectfully, Your obedient servant, W. W. KEEN, M.D. 1729 CHESTNUT STREET, Philadelphia, Oct. 10, 1874. THE EARLY HISTORY OF PRACTICAL ANATOMY. IN welcoming you here this evening, gentlemen, at the beginning of the winter session, and welcome you I do with the sincerest pleasure, it has occurred to me that in no way could we spend a pleasanter hour than in re- viewing the Early History of Practical Anatomy. We shall see in the difficulties that attended its introduction, and the improvements that have been gradually intro- duced, how much better off we are than were our prede- cessors, and how zealously we should avail ourselves of these advantages. The life and labors of Vesalius have been so often and so fully discussed, that you have readily at hand the means of acquainting yourselves with them. I shall not, there- fore, enter into these in detail, but only allude to them when necessary. But Vesalius, who was born in 1514, although the real father of anatomy, was by no means the first who practised human dissection. If we wish to see its starting-point, we must go back to ancient times. We must retrace our steps to the third century before Christ, and transfer ourselves from the amphitheatre of Padua to that of Alexandria, to discover the bold innovators who 3 4 EARL Y HISTOR Y OF first forced the dead human body to disclose its secrets for the benefit of the living. Two centuries earlier still, Democritus and Hippocrates had taken the first tentative steps, in the examination of the bodies of the inferior animals, butjthey ventured no further than this. It is in Alexandria, three hundred years before Christ, that we meet with the first human anatomists, Herophilus and Erasistratus ; and they are said to have been such zeal- ous cultivators of the new science that they not only dis- sected the dead human body, but even the living, in order to search for the hidden springs of life itself. 1 It is curious to note how this belief that anatomists were addicted to ante-mortem dissection has not been peculiar to Egypt, but has pervaded all lands and all times. Vesalius was shipwrecked and died, when fleeing for his life on a similar charge. 2 The Edinburgh act of 1505, giving the surgeons the body of one criminal annually "to make an anatomic of," was guarded by the proviso, "after he be deid," 3 and even Staupa, a medical man, in his book on dissection, published in 1827, gravely advises the student to assure himself that the body is "really dead." 4 Even 1 Biographic Medicale par ordre chronologique, par MM. Bayle et Thillaye, Paris, 1855, tome i. p. 40. This charge of Tertullian is reason- ably accounted for on the ground that such rumors would naturally attach themselves to the first dissectors of the human body. It is stated that Cocchi, in his " De Usu Art. Anat.," Florence, 1736, has vindicated them from the charge. Surgeons, however, not infrequently have been allowed to test operations on criminals, who were pardoned if they survived. Galen thus operated in cases of nerve-wounds, and Pare, Colot, and numerous other surgeons, in cases of lithotomy. a Bayle et Thillaye, op. cit., tome i. p. 231. 3 Prof. Struthers's Hist. Edin. Anatom. School, Edin. Med. Journ., Oct. 1866, p. 289, note. 4 Hyrtl, Handbuch der Zergliederungskunst, pp. 51-2. PRACTICAL ANATOMY. 5 poetry has lent its aid to perpetuate the legend of the "Invisible Girl," whose ghost was believed to haunt Sir Charles Bell's anatomical rooms, where she had been dis- sected alive on the night preceding that appointed for her marriage. 1 But the example of Alexandria in the cultivation of 1 See Gibson's Rambles in Europe, pp. 143-4. The poem does not follow the legend as to the dissection's being ante-mortem. THE INVISIBLE GIRL. i. 7. 'Twas in the middle of the night I vowed that you should take my hand, To sleep young William tried ; But fate gave us denial ; When Mary's ghost came And stood at his bedside ng in You'll find it there at Dr. Bell's, In spirits and a phial. Oh, William, dear! Oh, William, My rest eternal ceases ; Alas ! My everlasting peace Is broken into pieces. dear ! As for my feet, my little feet, You used to call so pretty, There's one, I know, in Bedford Re The t'other 's in the city. I thought the last of all my cares Would end with my last minute, But when I went to my last home, I didn't long stay in it. I can't tell where my head is gone, But Dr. Carpue can ; As for my trunk, it's all packed up To go by Pickford's van. The body-snatchers, they have come And made a snatch at me ; It's very hard them kind of men Can't let a body be. I wish you'd go to Mr. P. And save me such a ride ; I don't half like the outside place They've took for my inside. You thought that I was buried deep, Quite Christian-like and chary ; But from her grave in Mary-le-bone, They've come and boned your Mary. The cock, it crows, I must be gone ; My William, we must part; But I'll be your's in death, although Sir Astley has my heart. The arm that used to take your arm Is took to Dr. Vyse ; And both my legs are gone to walk The hospital at Guy's. Don't go to weep upon my grav And think that there I be ; They haven't left an atom there Of my anatomy. 6 EARL Y HISTOR Y OF anatomy aroused no imitators no rivals. For several centuries Egypt was the only medical centre of the world. Anatomists of every country resorted thither, and in the second century after Christ we find Galen compelled to go from Pergamus to Alexandria in order to see a skeleton. Even in Rome itself, and as court physician at a later period, Galen could dissect nothing but the lower animals. The burning of the dead by the Romans prohibited totally any attempt at anatomy, and instead of sending his stu- dents to Egypt to study anatomy, he sent them to Ger- many to dissect the slain among the national enemies, while he contented himself with the ape. 1 This feeble light at Rome and Alexandria, however, was soon extinguished, and human dissection disappeared from history for twelve centuries. The twilight of the well-named "Dark Ages" had set in, and when, in A.D. 640, the vast treasures of the Alexandrian library were burned, night itself came on. So long and so deep has that night been in the very natal city of human anatomy that it is but six years since the death of Clot Bey, the first public lecturer on anatomy in Alexandria for about seventeen hundred years; and so strong are Mussulman prejudice and hatred, that, although under the protection of the Pasha Mehemet Ali, when he first opened the thorax of a body a student rushed upon him and stabbed him with a poniard. The blade slid over the ribs, and Clot Bey, perceiving that he was not seriously hurt, took a piece of plaster from his dressing-case, and, applying it to the wound, coolly observed to the class, "We were speaking, gentlemen, of the disposition of the ribs and sternum, and I now have the opportunity of showing how 1 Hyrtl, Lehrbuch der Anatomic des Menschen, 8te Auflage, Wien, 1863, p. 230. William Hunter's Introductory Lectures, p. 24. PRACTICAL ANATOMY. 7 a blow directed from above has so little chance of pene- trating the thorax," and went calmly on with his lecture. 1 The Mohammedans, into whose hands medicine passed at the fall of Alexandria, wholly abandoned dissection, and, as we have just seen, had even the fiercest prejudice against it, based on its prohibition by the Koran and the seven days' ceremonial uncleanness it denounced against all who even touched a dead body. Galen's anatomy of the ape reigned supreme till the time of Vesalius, in 1543. Even then this substitution of the lower animals for man was neither wholly nor easily overthrown. In Paris we find Sylvius, the teacher, and afterwards the fierce oppo- nent of Vesalius as an innovator, lecturing "from small fragments of dogs." 2 The ape was preferred by many on account of its outward resemblance to man, but swine were the favorites, 3 because, being omnivorous animals, they still more closely resembled the human race, "es- pecially," says Hyrtl, with one of his usual sly thrusts, "certain individuals among them." Vesalius himself so far yielded to the popular fancy that some of his descrip- tions are drawn from this very source, and the frontispiece of his anatomy, in the edition of 1555, shows a perfect menagerie of apes, goats, and dogs. In 1627, Spigelius similarly honors the swine ; 4 and even so lately as the middle of the last century, William Hunter tells us that "the operations of surgery were still explained to very little purpose upon a dog." 5 But with the rise of the Italian universities came the first gleams of light. Bologna, the oldest of them all, is 1 Medical Times and Gaz., Sept. 19, 1868. 2 Morley's Life of Jerome Cardan, vol. ii. p. 100. 3 Hyrtl, Zerglied., p. 28. Text and note. 4 Ibid. 5 Introductory Lectures, p. 88. 8 EARL Y HIS TOR Y OF in many respects the most famous. Founded in 1119 as a school of Roman law, the fame of her professors was such that, as early as 1262, no less than ten thousand students were gathered there. 1 The faculties of medicine and of arts were founded before the fourteenth century, and soon added to her fame. Here, two centuries before Vesalius was born, the first dissections of modern times were made. In 1315, Mondini, or Mundinus, publicly dissected two female bodies, 2 and established what was intended to be an annual custom, but which, strange to say, was soon neglected. Bologna, the first in the new era of medicine, has not since then been behind her rivals in the healing art. The names of Carpi, Vesalius, Arantius, Malpighi, Valsalva, Varolius, and Galvani, alone, are enough to make her famous. But she was also the earliest exponent of one of the great questions of the present day in medical as well as other circles. Her female professors have rivalled their male associates in distinction. In medicine she has even had a professor of anatomy, Madonna Man- zolina, and, in 1865, I saw in the museum preparations made by her that would do credit to our own times. 3 In 1732, Laura Bassi was made doctor of laws and lecturer on philosophy, and in 1817, the immediate predecessor of that 1 Encyc. Britan., vol. xxi. p. 449. In the fourteenth century there were thirteen thousand. Paris had at one time as many as thirty thousand. 2 New Am. Cyc., first ed., article "Anatomy," i. 519. Encyc. Brit., eighth ed., article "Anatomy." Curiously enough, William Hunter, in his Introductory Lectures, does not mention Mondini, but traces modern anatomy back only to Leonardo, and says he was the first to go even thus far back. 3 Notwithstanding diligent search in every history and encyclopaedia here and in New York, I could find neither notice nor life of this leader among female physicians. Unfortunately, my journal states only the fact noted in the text. I would be glad to receive any information on the subject. PRACTICAL ANATOMY. 9 astonishing linguist, Mezzofanti, in the Greek chair, was Matilda Tambroni. In the fourteenth century we find Novella d' Andrea, the professor of canon law; 1 and such was her beauty that she had a curtain " Drawn before her, , Lest if her charms were seen, the students Should let their young eyes wander o'er her, And quite forget their jurisprudence." Yet notwithstanding the fame given to the Bolognese School and the impulse given to anatomy by the teaching of Mondini, the science retrograded, and all the Italian schools declined. The time of renovation had not yet arrived. The school of Salernum, which had been the most famous for several centuries, mourned by Petrarch, passed even out of existence. 2 The dark ages were not yet over. Boccaccio laments that when -visiting the library of the celebrated monastery of Monte-Casino, near Naples, he found the doors gone, grass growing in the windows, and the precious books and manuscripts yet undestroyed covered with dust and mould. 3 From Mondini to Vesalius, the best anatomist of his age was undoubtedly Leonardo da Vinci, the great artist. Not only did he dissect the horse and other inferior animals, but also the human body. From 'these dis- sections he made his celebrated Sketch-book of drawings in red chalk, now in the British royal collection at 1 Encyc. Brit., vol. xxi. p. 451. 2 Frederick II. (Charles II.? 1285-1309), of Naples, prohibited sur- geons from practising unless they understood " the anatomy of the human body, without which one cannot perform any operation, nor direct the cure after having done it." Malgaigne's edition of Fare's works, Introd., p. xxx. Did they then dissect? I can find no record of it, yet this would suggest it strongly. 3 Malgaigne's Pare, Introd., p. xlvif. 10 EARLY HISTORY OF Windsor, and labelled by him with reversed letters, so that they have to be read by a looking-glass. 1 But now came the revival of learning early in the six- teenth century. That wonderful awakening of the human mind which was manifested in the discovery of America, of the passage to the East Indies, and of the solar system, and in the invention of printing, of the compass, and of gunpowder, could not but find a new path of progress in medicine as well. Vesalius took the lead in 1537, as a teacher of genuine anatomy in Padua, and in 1543 he published his splendid work which soon revolutionized the science. A host of anatomists followed in his path. Columbus, Eustachius, Fallopius, Fabricius, Gasser, In- grassius, Arantius, Vidius, Varolius, and others, all dili- gent anatomists of the sixteenth century, have left their mark in the household names of elementary anatomy. I say elementary anatomy advisedly, for the first dissections were both naturally and of necessity confined to the grosser, ocular parts of the body. The bones, muscles, and viscera were almost the only well-dissected and well- described parts, and if we except Vidius and his perplex- ing "Vidian nerve," none of the anatomists just men- tioned have their names associated with any of the finer parts. For sucH minuter investigation, grosser anatomy had first to clear a path. Bodies also were too few, and had to be too hastily dissected; and their instruments were too imperfect. The dissecting-forceps, without which no minuter dissection could be carried on, is not certainly 1 Wm. Hunter, Introd. Lect., pp. 37-39, and R. Knox, M.D., "Great Artists and Great Anatomists," London, 1852, " Leonardo." It is un- derstood that these sketches will soon be published. Many autotype reproductions of other sketches by Leonardo have been published by Braun, of Dornach, and they amply attest his wonderful knowledge of anatomy. PRACTICAL ANATOMY. over one hundred and fifty years old, and may be far less. 1 Not to speak of modern pictures representative of practical anatomy, Rembrandt's famous painting in the Hague, about two hundred years old, represents Van Tulp demonstrating the muscles with our ordinary surgical dressing-forceps. This awkward substitute, together with double hooks on a handle, 2 and the fingers were then the anatomist's only resources. Moreover, no good means had as yet been devised for preserving bodies for more prolonged and delicate dissections, nor for injecting the vessels, nor for making permanent preparations, whether for reference or for teaching ; and models were undreamed of. Discouraged by many as a useless innovation ; frowned upon by others as repugnant to our better feelings ; ob- structed by the law; treated even as impious; fostered only by the love of knowledge and by its own necessity, the science found fewcultivators among the bulk of the profession. Among the teachers of anatomy it was not infrequent, but beyond the lecture-room no dissecting-rooms existed. Students saw the demonstration, and that was all. None of them dissected for themselves. Nor when we come to later times do we find the case rapidly bettered. The first Monro says that in his student days, early in the last cen- tury, his Scotch anatomy was limited "to seeing the dis- section of the human body once in two or three years." 3 In William Hunter's time, at the end oi the same century, practical anatomy was unknown to the mass of the pro- fession until he established the celebrated Great Windmill Street School. In 1866, we find Prof. Struthers, of Aber- 1 Hyrtl, Zerglied., pp. 19 and 20. 2 See them figured in Michael Lyser's Culter Anatomicus, Amstel., 1653- 3 Edin. Journal, Oct. 1866. " Hist. Edin. Anat. School." 1 2 EARL Y HISTOR Y OF deen, saying, "Less than a generation ago it was not an uncommon thing to find medical practitioners who had never dissected." J And even to-day, after considerable personal experience as a teacher of anatomy, I have grave doubts whether the majority of our students dissect the human body more than once. But, in spite of these obstacles, anatomy, both descrip- tive and practical, went on gaining favor with both its teachers and the profession at large. Italy, the focus of the arts and sciences in the revival of Greek learning, naturally took the lead. In her cele- brated universities professorships of anatomy were founded early in the sixteenth century, and her schools were crowded with hundreds, and even thousands, of students from all parts of Europe, who returned to their native cities, carrying with them patriotic desires for the ad- vancement of science in their own lands. 9 England was among the first to profit by the shining example. Soon after the founding of the College of Sur- geons in 1540, through the influence of Dr. Caius, the king's physician, and the founder of Caius College, Cam- bridge, Henry VIII. granted to the College of Surgeons the privilege of dissecting four felons annually, and in 1564 Elizabeth gave the same privilege to the College of Physicians. 3 In 1581 the latter college created the lec- tureship on anatomy, and in 1583 built in Knight Rider Street the first anatomical theatre. Here, in 1615, Harvey was elected lecturer, or, as it was then called, reader, in 1 Edin. Journal, Oct. 1866. " Hist. Edin. Anat. School." a From 1204, when the University of Vicenza (the first after Bologna) was founded, to 1445, eighteen universities were founded in Italy alone, and thirteen more in other parts of Europe, to which thirteen others were added before the year 1500. 3 " The Gold-headed Cane," pp. 91-2. PRACTICAL ANATOMY. ! 3 anatomy, and here he gave his first public demonstrations of the circulation of the blood about a year later. 1 The facilities for general medical dissection, however, were very limited, and, as if to discourage it still further, in 1745 a fine of ^10 was imposed on any one dissecting outside of Barber-Surgeons' Hall. But such a state of affairs could not long exist. The profession, under the lead of William Hunter, soon broke away from such bonds, and for over half a century almost every distin- guished anatomist had dissecting-rooms attached to his private dwelling, where he and his pupils cultivated the science. In 1770 William Hunter bought a lot in Great Windmill Street, London, opposite the Haymarket, and built on it a dwelling-house, an anatomical theatre, dis- secting-rooms, and a museum. The lecture-room was lighted from above, and the seats rose as in our own amphitheatres. Here he lectured, assisted by his brother John, by Hewson, and by Cruikshank, till his death, in 1783. Here he collected his splendid museum, now in Glasgow, at a cost of ^100,000," and his brother John began his own collection, which cost him before its com- pletion ^7o,ooo, 3 and now forms the chief ornament of the Museum of the Royal College of Surgeons. At Wil- liam Hunter's death the anatomical school passed into the hands of his nephew, Baillie, and then successively to Cruikshank, Wilson, Sir Benjamin Brodie, Sir Charles Bell, and Shaw, and finally to Mayo and Caesar Hawkins. On Mayo's removal, in 1833, to University College Hos- pital, this celebrated school came to an end. 4 But it had 1 " The Gold-headed Cane," pp. 95-8. 2 Brodie's Works, vol. i. p. 448. 3 Life of John Hunter, p. 72. 4 For these and other interesting particulars as to this celebrated school, see " Letter from Sir B. Brodie to Dr. Craigee," in Appendix to Thom- son's " Life of Cullen ;" Pichot's " Life and Labors of Sir C. Bell ;" Wm. 2 ! 4 EARLY HISTORY OF left its mark. Thousands of educated anatomists had gone forth from its walls to practise all over Great Britain and in this country. It furnished William Hunter's mu- seum to Glasgow in 1807, John Hunter's to the Royal Col- lege of Surgeons, London, and, later still, those of Wilson and Sir Charles Bell went to ornament the museum of the College of Surgeons of Edinburgh, and that of Mayo to University College, London. From it as a foster-mother, too, along with the institution of new public schools connected with the hospitals, many other private schools sprang up, and presented the finest opportunities for the diffusion of anatomical knowledge, so that in 1825-6, be- sides the hospitals, there were no less than seven such private schools of anatomy in London. 1 Next to England in point of time, Holland was the fore- most in cultivating anatomy in its modern revival. Ruysch, Swammerdam, Albinus, and Boerhaave, in the last half of the seventeenth century, were not only the anatomical lights of their pwn country, but also of all Europe, and especially of Germany through Haller, and of Scotland through the Monros. I have already quoted the Edinburgh act of 1505, which allowed of the annual dissection of a criminal, and also the early experience of the first Monro, which shows how rarely this was made available. The first Scotch anatomi- cal theatre was built, and the first public demonstrations given, in 1697. But it was not till 1720 that a regular Professor was appointed. At that date Monro primus was elected Professor, at the extraordinary salary of ^15 per annum! From this time till 1859, when Monro the third died, the history of Edinburgh anatomy, Hunter's Introd. Lects., Lect. 2d, and fol. papers; John Hunter's Life, and Life of Hewson. 1 Lancet, 1825, pp. 26 et seq., gives a list of them all. PRACTICAL ANATOMY. ! 5 and that of this astonishing family, are almost identical. True, John Bell and Knox, Charles Bell, Barclay, Innes, and others, lectured in private schools ; but the Monros held the sceptre. All of them lived to old age, Alexander primus dying at seventy, Alexander secundus at eighty- four, and Alexander tertius at eighty-six. All were pro- fessors early in life ; at twenty-three, twenty-one, and twenty-five respectively. All of them taught for long periods: thirty-eight, fifty-four, and forty-eight years ; and father, son, and grandson, they held the anatomical chair in Edinburgh from 1720 till 1846, a period of one hundred and twenty-six years ! x In view of the fact that this our own city was only founded in 1682, it shows unusual vigor and enterprise that in 1751 less than seventy years after it was a wilder- ness Dr. Cadwalader, a pupil of Cheselden, in London, gave demonstrations in anatomy in Second Street above Walnut. Eleven years later, Dr. Shippen, Jr., a pupil of the Hunters, became a regular lecturer, and the founder of the medical department of the University of Pennsyl- vania. The following is his announcement in the Penn- sylvania Gazette of November 25, 1762: "Dr. Shippen's anatomical lectures will begin to-morrow evening at six o'clock, at his father's house, in Fourth Street. Tickets for the course to be had of the doctor, at five pistoles each, and any gentlemen who incline to see the subject prepared for the lectures, and learn the art of dissecting, injections, etc. , are to pay five pistoles more. " His Introductory was delivered in the State House, and his class numbered twelve. Three years later his house was mobbed for al- leged violation of the church burying-ground, an assertion which the doctor denied in a public announcement, and 1 Edinb. Journal, Oct. 1866. " Hist. Edinb. Anat. School." !6 EARLY HISTORY OF at the same time declared that he had only dissected the bodies of "suicides, executed felons, and now and then one from the Potter's Field." ' Dr. Shippen was not alone in this misfortune, for Monro was mobbed in 1725, Macartney in Dublin many years after, and Sir Astley Cooper and others have barely escaped it, besides all the fights and riots in which students and resurrectionists have been involved ; and all these troubles point to a difficulty which from the dawn of practical anatomy has always been felt. The problem how to obtain a sufficient knowledge of anatomy and yet not to do vio- lence to the feelings of the community, is one difficult of solution. Had all anatomists been even so gallant as Riolan, physician to Louis XIII., who dissected females only on couches of germander, daphne, clematis, and thyme, and entombed them in their floral beds, 3 yet the difficulty would not have been overcome. The problem was only solved by the anatomy acts which were passed in England in 1832, 3 on the continent at various periods some years before, and in this country by Massachusetts in 1 83 1 4 and New York soon after. But these acts were only obtained after the community had been driven to it, not only by the repeated outrages to the public peace and public feelings, but also by repeated crimes. When a student with Sylvius in Paris, Vesalius had to prowl around the places of execution and spoil the gallows 1 Carson's History Med. Dept. Univ. Penna., pp. 39, 40, 80-1, and Ap- pendix, p. 217. For many other interesting facts in the early history of anatomy in this country, see Prof. A. B. Crosby's address before the New Hampshire Medical Society (1870). a Riolan's " Enchiridium," quoted by Hyrtl, Zerglied., p. 31. 3 For this act, known as the Warburton Act, see the Lancet, 1831-1832, P- 7I3- 4 For copy, see Am. Journ. Med. Sci., vol. viii., 1831, p. 264. PRACTICAL ANATOMY. I 7 of its victims, and to retain his booty was sometimes obliged to hide the bodies even in his own bed. 1 The more enlightened, though cautious rulers and legislative bodies, soon provided a partial supply. The first recog- nized source, and until the present century the only legal one, was from executed criminals an illustration of which maybe seen in Hogarth's "Reward of Cruelty." But Cortesius tells us about 1600, that so jealously guarded was this privilege (in Messina) that in twenty-four years he could but twice dissect a subject, and then under great difficulties and in great haste. 2 What a contrast to the five thousand now annually dissected in Paris alone ! 3 In England it was not till the reign of George II., in 1726," that #// criminals, instead of a few, were given for dissection. This act was in force till 1832, but this source of supply was insufficient even when executions were more frequent than now. In all Great Britain, from 1805 to 1820, there were executed eleven hundred and fifty crim- inals, or about seventy-seven annually ; and at the same time there were over one thousand medical students in London and nearly as many in Edinburgh. The result was a natural one. The graveyards were rifled ; and, as the demand was a permanent one, there arose a set of the lowest possible villains who provided a permanent supply the resurrectionists a race of men now happily almost extinct. At first but few in number, they soon rapidly increased, till in 1828 there were in London over one hundred reg- ular resurrectionists, 5 besides many occasional volunteers ; 1 Morley's Life of Jerome Cardan, vol. ii. p. u. 2 Hunter's Introd. Lect., pp. 41-2. 3 Hosp. and Surgeons of Paris, by F. C. Stewart, pp. 144-5. * 9 George II. cap. 31, Lancet, 1834-5, vol. i. p. 356. s Lancet, 1828-9, p. 793. 2* X 8 EARLY HISTORY OF and their trade was so extensive, that if the police were more than usually vigilant in Edinburgh or Dublin, they would supply those more distant schools. Their skill was such that no-obstacle was insuperable. The police watched the grounds they were either bribed or made drunk; relatives replaced them but a half-hour's unwary slum- ber on the part of the weary watcher was enough for an adept ; high walls were built they scaled them ; spring- guns were set they sent women as mourners to the fu- nerals, who discovered the position of the pegs ; a stone, an old branch, a blade of grass was made to act as a detective on a newly-made grave but the practised eye of a regular would detect it in a moment, and replace it after the theft. Such adepts were they that Sir Astley Cooper, in his evi- dence before the Parliamentary Committee, declared that no matter what the social position of any person in Eng- land, he could obtain his body if he desired it ; x and such villains were they, that, for a respectable price, they would unhesitatingly make a subject of him, their best though unwilling patron. The laws against their crimes, and the vigilance of the police, had but one effect not to stop the trade, but only to increase the cost of subjects. 3 The ordinary charge was from ^7 to ^10 apiece, but often this was largely increased. In 1826 the price was as high as ;i6 to 22 ; and sometimes, when the police were unusually vigilant, even ^30 $150 were paid for a single subject ! 3 Their avarice was unbounded. Stimulated by Life of Sir A. Cooper, vol. i. p. 407. ? So imperfect was the supply, that a serious proposal was made to im- port the subjects from France to Ireland. Lancet, 1826-7, p. 80. 3 Lancet, 1826-7, vol. ii. p. 80; and 1828-9, vo1 - i- PP- 434 and 563; 1837-8, vol. i. p. 589. Life of Sir A. Cooper, vol. i. pp. 361, 396, 397, 403. Some of the resurrectionists died rich. See A. Cooper's Life, vol. i. pp. 416-18. PRACTICAL ANATOMY. ! 9 the jealousy and rivalry of the various schools, they usually demanded a special fee at the beginning and the end of every session in order to obtain their favor ; and so necessary were they, that they were often paid as high as ^50 to ;6o in these special fees; and in case any one was imprisoned, his bail was paid, and often, also, an allowance of ten shillings per week while in jail. In one case recorded by Bransby Cooper, this was continued at least during two years. 1 But when any subject was spe- cially desired by an enthusiastic anatomist, then was their carnival of extortion. In 1783, when 'O'Brien, the Irish giant (whose skeleton, eight feet four inches high, now adorns the Hunterian Museum of the College of Surgeons), was in failing health, John Huntersent his servant Howison to watch the disposition of the remains. This fact unfor- tunately coming to the knowledge of the patient, in his unbounded horror of the surgeon's scalpel he ordered that after death his body should be watched day and night till a leaden coffin could be made, in which he should be taken to sea and buried there. Soon afterwards he died, and the watchers were set. Howison, having discovered the tavern where they refreshed themselves when off duty, soon struck a bargain with one of them, that if his com- panions would agree to it, the body should be stolen at night, and for their consent the watchers were to receive $o. The others, satisfied with all but the price, de- manded ;ioo, which Hunter agreed to pay. Finding him so eager, they soon made other difficulties, and again and again increased the price until they had raised it to ^500 ! Accordingly, the body was stolen at night, conveyed in Hunter's own carriage to his dissecting- room, and immediately prepared, but with such haste, 1 Sir A. Cooper's Life, pp. 360-2 and 369. 20 EARLY HISTORY OF for fear of interruption, that the bones could never be properly whitened. 1 O'Brien's coffin was not the only one which contained what might be called a " foreign body" when the clergy performed the burial service. Such thefts became a regu- lar part of the trade, and if a night intervened between the finding of a body and the holding of a coroner's in- quest, it was liable to disappear, and the resurrectionist often attended the inquest to see the astonishment of the jury. Sometimes they picked up cases of apoplexy in the street, carried them to one of the hospitals as relatives, claimed the body after death, and quickly assuaged their grief with the guineas from the anatomical school of another hospital. Patrick, one of the most celebrated of the gang, for some months carried on successfully the ruse of claiming relationship with dying men and women, whose names he ascertained, in the various workhouses, and his career was only cut short by the jealousy of a rival named Murphy, who denounced him to the authori- ties. But Murphy himself adopted a similar plan on another occasion. Observing one day, while walking, a neat .meeting-house with a paved burial-ground, in which was a trap-door, he soon returned in a suit of solemn black, seeking a quiet sanctuary for the remains of his wife. Descending into the vault to select the place of her repose, while the back of the sexton was turned he quietly slipped the bolts of the trap-door, and that very night, entering the vault by this means, he rifled every body there of the teeth, which, as porcelain teeth were then unknown, he sold to the dentists at a net gain of ;6o. Once, a body stolen from the grave was sold to 1 Otley's Life of John Hunter, pp. 106-7, in Palmer's Ed. of Hunter's Works, London, 1835. PRACTICAL ANATOMY. 21 Lizars, in Edinburgh, and paid for ; was re-stolen from Lizars's dissecting-room the same night and sold to Knox; the scoundrels netting ^25 in all, and without the possible fear of indictment, least of all for their second theft ! Sometimes adventurous students carried the plunder home in hackney-coaches, and this gave rise occasionally to amusing adventures. On one occasion, the hackman, aware of the illegal nature of his passenger's baggage, having arrived opposite the Bow Street police headquar- ters, thrust his head in at the window, and said to the uneasy occupant, "The fare, sir, to the hospital is a guinea, you know, unless you wish to be put down here." "Quite right, my man, drive on," was the unhesitating reply. Along with the debasing qualities necessarily developed by such an occupation, came also some of the more envi- able qualities of body and mind. Thus, on one occasion, when a party of medicals, headed by a noted Edinburgh surgeon, were discovered in a city churchyard, the chief actor laid hold of two large adults, just disinterred, and, carrying one under each arm, escaped into the garden of a private institution under the stimulating fire of blunder- busses. But strategy and adroitness, combined with brute force, were still more frequently called into play. A country lad, whose disease was peculiar and his skeleton much desired, had been buried in an exposed cemetery, in a fishing village on the Firth of Forth, and watchers were set. The resurrectionists, in full force, attempted to bribe them, to outwit them, to entrap them, but all to no avail. Weeks passed by, and the excitement was grad- ually dying out, when, one evening, at dusk, two well- dressed gentlemen, smoking their cigars, drove up in a dog-cart to the little inn and alighted. The whip-hand gentleman told the hostler that he expected a livery ser- 22 EARLY HISTORY OF vant to bring a parcel for him which was to be placed in the box. In a short time the parcel was delivered, and presently the two gentlemen returned and departed. The sharp-eyed stable-boy could not help remarking that the livery servant who brought the parcel "was deuced like the off-side gentleman," and fancied he saw a bit of scarlet lining under his brown overcoat. " Haud yer tongue, Sandie," said his superior; "ye're aye seeing farlies." While the gentlemen were driving away, the watchers were approaching the grave, and, to their utmost astonishment, it had been despoiled. Liston, the Edin- burgh surgeon, and Crouch, the London resurrectionist, needed but thirty minutes for such work, especially by daylight. All the detectives were put upon the track, and all the dissecting-rooms searched, but in vain. Years afterwards, skeleton No. 3489, with the donor's name attached, was added to the noblest anatomical collection in Britain. 1 The bodies were generally left in the night in bags, and this gave them occasionally a chance too good to be lost. They bagged drunken men on the street and de- livered them as subjects, sometimes to their great aston- ishment, at others with their connivance. Mr. Clift, the curator of the Hunterian Museum, was once thus waked up while a student with John Hunter, and two bags de- livered and paid for on the spot. The men had gone but a few steps when Mr. Clift perceived the swindle, and, though in his night-clothes, he ran after them, collared the principal, and said to him, "You've left me 1 These details, and many others equally interesting and amusing, may be found in the account of the Resurrectionists, in the Life of Sir Astley Cooper, vol. i. pp. 334-448, and in Lonsdale's Life of Robert Knox, the Anatomist, pp. 47-116. The comic side of the subject may be seen in Hood's " Jack Hall" (Jackal), in his Whims and Oddities. PRACTICAL ANATOMY. 23 a live man." "I know it," said the man, shaking off his hold and escaping with the money; "you can kill him when you want him." ' But such a degrading occupation necessarily debased the men to the level of any crime. The increasing number of students leading to a growing demand for subjects, and the increased vigilance of the police adding to the difficulty of procuring them, the fears of medical men that murder would be resorted to were soon realized. In 1827 the University of Edinburgh, with nine hundred students in its class, for the first time made dissection compulsory, and thus greatly stimulated the demand. London, Liverpool, and Dublin all in turn supplied the want, but the prices obtained soon gave rise to the horrible crimes of Bishop, 2 in London, and Wm. Burke, in Edinburgh ; the latter, from the atrocity of his crimes, being made eternally infamous by giving his name to the crime of "Burking." His trial, twenty-four hours long, one "of unexampled length," said the judge, by curious contrast to our more tardy justice, took place December 24, 1828. After his conviction he made a confession of all his many crimes. 1 The late Prof. S. H. Dickson informed me that he had this not uncom- mon "Joe Miller" of the present day from Mr. Clift personally. 2 I found this man's crimes alluded to several times in the Lancet, 1832-3, vol. i. pp. 244, 341, 568, when first preparing this lecture; but, notwithstanding the most thorough search, I was unable to obtain any of the particulars, save that he and a man named Williams murdered an Italian boy, and were betrayed by Hill, the dissecting-room porter at King's College. Since then, Dr. J. F. Clarke has published his "Auto- biographical Recollections of the Profession." In this entertaining book (pp. 100-104, and the Medical Times and Gazette, March n, 1871) a full account of the facts is given. A curious bit of history is added in the London letter of the Philadelphia Medical Times of May 17, 1873, P 524, showing how the murderers were detected by the sagacity of the late Mr. Partridge. 24 EARLY HISTORY OF While he and his mistress, Helen McDougall, were lodging with a man by the name of Hare, one of the lodgers died owing Hare 4. They took the body to Dr. Knox, and sold it for 7 -LOS. Finding it so profitable, the three then proceeded to smother every available lodger who fell into their hands, and, in the year that elapsed before their detection, sixteen persons had thus been murdered. Burke was executed Jan. 28, 1829, and, by order of the judge, like Anton Probst in this very city, was publicly dissected. 1 His skeleton is in the Anatomical Museum of the Uni- versity of Edinburgh, 2 and from his tanned skin John Arthur, afterwards janitor to Prof. John Goodsir, had made a tobacco-pouch, which he carried for many years as a memento of the period when he first became con- nected with the dissecting-room. 3 Such crimes called public attention to the imperative necessity of a proper source of supply for dissecting ma- terial. The Warburton anatomy bill accordingly was enacted August i, 1832, giving all unclaimed bodies, under proper regulations, to the various schools. This has been the model for all subsequent acts, our own passed but six years ago among them. For several years there were loud complaints as to its operation, 4>ut experience gradually removed its difficulties, and now it supplies all the schools well, and at moderate prices. The price in Edinburgh at present is $3 per part. 4 Our own act is 1 Lancet, 1828-9; his trial, pp. 424-31 ; his confession, pp. 667-8. 2 Lonsdale's Life of Knox, p. 76, note. This book contains a very full account of the career of Burke and Hare, and their relations with Knox. 3 Goodsir's Anatom. Memoirs, vol. i. p. 163, note. 4 Really the price of a "part" in Edinburgh is but 6.r. ($1.50), but the body is divided into ten parts two each to the head, the thorax, and the abdomen, and one to each of the four extremities. The body lies on its PRACTICAL ANATOMY. 25 suffering the same trial. Obstinacy and knavery are com- bined to defeat it, but I do not doubt that in the end it will gain the victory, and afford us an ample supply worthy of a great medical centre. Not only, however, do we have an immense advantage in these days over the so-called good old times in the facility of obtaining material, but also our means of pur- suing practical anatomy are vastly more perfect and more prolific. In the Museum of the Royal College of Physicians the curious observer will notice "six tablets or boards upon which are spread the different nerves and blood-vessels, carefully dissected," removed from the body and dried. "In one of them the semilunar valves of the aorta are distinctly to be seen." 1 Such are the, to us, wretched preparations with which Harvey illustrated his lectures on the circulation, and they were probably used before his royal patron, when he demonstrated his wonderful dis- covery to Charles I. He made them probably at Padua, under the eye of Fabricius, the re-discoverer of the valves in the veins. 2 If any one compares them with our splendid preparations and models, how insignificant they seem ! But they were among the first essays in a new art whose benefits are still felt by all medical students. back for three days to give time to have the thorax and abdomen opened and examined, and the perineum dissected; then on its belly, for dissec- tion of the muscles of the back and of the spinal cord. Each man then soon removes his own extremity, and dissects it separately. 1 Harlan's Gannal's Hist, of Embalming, p. 258, and Gold-headed Cane, pp. 127-8. Similar preparations are in the College of Surgeons, purchased in Padua, by John Evelyn, made by Fabritius Bartoletus, then Veslengius's assistant, and afterwards physician to the King of Poland. 2 Charles Etiennes (Carolus Stephanus) was the first who properly un- derstood the valves in the veins. He speaks of them (in his " De Dissec. 3 26 EARLY HISTORY OF Carpi, 1 Etiennes, 2 and Eustachius, 3 in the sixteenth century, and Malpighi, 4 Glisson, 5 and Willis, 6 in the seventeenth, had used air, water, milk, ink, and other colored fluids, with which to inject and trace the vessels. In Holland, however, the first substantial progress was made. DeGraaf, about 1668, improved the syringe, and injected mercury into the spermatic vessels. 7 Swammer- dam, Ruysch, and Albinus, however, really created and diffused the knowledge of the art of injections. Swam- part. Corp. Hum.," Paris, 1545, quoted in Hyrtl's Zerglied., p. 585, note), as " apophyses membranarum" which obviate the danger from re- gurgitation. This anticipates by two years Cananus, who, in 1547, when Fabricius was but ten years old, demonstrated the valves in the azygos veins. Aiken's Bibl. Med. " Harvey," p. 312, and Bayle et Thillaye, op. cit., i. p. 234. 1 Prof., in Pavia and Bologna, 1502-1527. He is the first who speaks of injections, when treating of the renal vessels "per syringam aqua callida plenam." Isagoga brevis in Anat. Corp. Hum. Bonon. 1522, in Hyrtl, Zerglied., p. 585. 2 He blew air into the veins by a metal tube. Hyrtl, Zerglied., p 585. 3 Eustachius, says Portal (Hist, de 1' Anatomic, Paris, 1770, torn. i. p. 634), injected " fluids of various colors and densities." * Malpighi used ink and other fluids assiduously, and by them made various discoveries in the kidney and elsewhere. 5 Glisson injected the liver with ink. Hyrtl, Zerglied., p. 586. Portal, iii. 261. 6 Willis injected the brain with "aqua crocata." He discovered the "Circle of Willis" by this means. The tubes of Bellini in the kidneys were discovered in a similar manner. The pains anatomists took at that time were even so great that a preparation by Hildanus (A.D. 1624) is said to exist in Berne, which exhibits the entire venous system dissected out by means of their distension by air, and the hundreds of ligatures that it would require. Hyrtl, Zerglied., pp. 586-7. 7 Encyc. Brit., vol. ii. p. 761. Portal, Hist, de 1'Anat., torn. iii. pp. 220-1, 261. Strangely enough, Hyrtl ( Zerglied., p. 587), who is usually So exact, attributes the first mercurial injections to Nuck, whose work (Adenogr. Curios. Leydae, 1692) was published twenty-four years later than De Graaf's " De Usu Siphonis." PRACTICAL ANATOMY. 27 merdam saw that in order to fulfil its purpose the material used ought to be injected as a fluid and yet solidify in the vessels, and not evaporate as water did. He first used suet; in 1667 he substituted wax, and in 1672 he sent to the Royal Society a preparation thus injected. 1 His suc- cess was such that in his best preparations he filled even the arteries of the skin of the face. Two years later he gave up anatomy as impious, joined the party of a religious fanatic, and died in 1680. Before relinquishing his profession he made his method public in Amsterdam, Paris, and London, and gave special instruction to his friend and fellow-townsman, Ruysch, who pushed the art so far that he was said to believe that the body was almost wholly made up of vessels. 2 Leu- wenhoeck, another citizen of Leyden, had fortunately just at this time invented, or rather made really available, the microscope, 3 and thus Ruysch was enabled not only to inject finer vessels directly, but also to discover, as re- sults of his injections, networks of vessels hitherto un- suspected. 4 His first trials were made on the bodies of 1 Portal, Hist, de 1'Anat., Hi. 334. 2 This erroneous belief (totum corpus ex vasculis) was really held by Ruysch and nearly all his contemporaries. "Antoine Ferrein," says Sprengel (Hist, de la Med., torn. iv. p. 338), "was the only one who ad- vocated the parenchyma of the organs against Ruysch and Malpighi." It was long held by Boerhaave's school also. 3 Magnifying lenses of rock crystal were found in the palace of Nim- roud, by Layard. The compound microscope was invented by Hans Zansz, spectacle-maker, at Middleburg, Holland, in 1590. Encyc. Brit., 8th ed., art. " Microscope," p. 801. 4 He discovered the vasa vasorum, the bronchial arteries, the vessels of the middle layer of the choroid, called the " Tunica Ruyschiana" (though this was first accurately described by Zinn, in 1755), the finervessels in the serous and synovial membranes, the pia and dura matres, the corpora cavernosa, and many parenchymata. Hyrtl, Zerglied.,p. 594- Sprengel, Hist, de la Med., torn. iv. pp. 144, 233, 277-8. 28 EKRL Y HISTOR Y OF infants, but finally, when, in 1666, Admiral Berkeley was killed and his body captured in the memorable four days' fight between the English and the Dutch fleets, Ruysch successfully embalmed his body by order of the States General, and sent it back to England with an almost nat- ural appearance. 1 Such was his success, 3 says M. Fonte- nelle, that he seemed not only to preserve men after death, but rather to prolong their life. At the close of his long career they remained perfectly preserved, with their orig- inal softness, flexibility, and color. In his museum, which was called the eighth wonder of the world, the dittce and the utile were elegantly combined. Flowers, ornamental shell-work, and rarities worthy a royal cabinet were interspersed with skeletons, injections, and other anatomical pieces, 3 and many of them, especially the fcetal skeletons, were labelled with appropriate and in- structive mottoes. Thus, one who did not attain to even uterine maturity holds an inflated bladder aloft, and teaches us the shortness of life in its motto, "Homo Bulla," "Man but a bubble." Another holding a prep- 1 Bayle et Thillaye, op. cit., vol. i. p. 528. Portal, Hist, de 1'Anat., torn, iii. p. 262. So natural was one infant's body that Peter the Great is said to have kissed it. 2 Hyrtl (Zerglied., p. 597) found the process described by J. Ch. Rieger (Introd. in notitiam rerum natural, et artefact., etc. Hagse, 1743, 4to, 2 vols.) under "Animal" (vol. i.) and " Balsamus" (vol. ii. pp. 54-7). The latter contains a copy of Ruysch's autograph directions as to his mode of injection and preservation. The following are extracts: "Pro materie ceracea sumendum sebitm, et quidem tempore hyemali simplex aestivo tempore exiguum frustum cerce alba addendum. Liquefactse materise additur cinnabaris factitise quantitas sufficiens, aut quantum vis, idque movendo, donee bene permixta sit cinnabaris. Liquor meus est spiritus, e vino, vel frumento confcctus, cui si addere velimus in destillatione manipu- lum piperis iiigri, eo acrius penetrat per carnosa spartes." 3 Bayle et Thillaye, op. cit, vol. i. p. 529. The plates in his " The- saurus Anatomicus," i.-vi., Amstel., 1701, in my own library, illustrate these quaint but withal artistic arrangements. PRACTICAL ANATOMY. 29 aration of the lymphatics showing their valves, which was made twenty-five years before, and not long after their first discovery by Aselius, in 1622, reminds you they are "as difficult as beautiful." A third, a uterus containing a foetus, hints at a questionable paternity : " Quo minime credis gurgite piscis erit," "Fish may be found in least suspected pools." A still-born child's motto, " Hsec mihi prima dies, haec mihi summa fuit," "This my first day was my last," reminds one of the laconic epitaph in a similar case " If I was so soon to be done for, What was I ever begun for?" And the head of a noted woman of Leyden, whose finger points to the syphilitic perforations of her skull, has the warning motto, " In similar waters similar fish are found." l The museum was the admiration of all distinguished men at home and abroad. Generals, ambassadors, princes, and even kings delighted to visit it, and spend whole days with its author. 2 Peter the Great, when in Holland, in 1 698, thus divided his time with Leuwenhoeck and Ruysch : he attended the lectures of the latter, and became an earnest student of medicine. He always carried a small surgical case. He learned to draw teeth, to bleed, and to dissect. So enthusiastic a pupil did he prove that he always occupied the front seat, and during one of the lec- tures he leaped up and was about to seize the scalpel the master held. 3 The Czar's surgical operations, however, did not prove so successful, for a Dutch merchant's wife 1 Ruysch, " Museum Anatomicum." An Appendix to his Opera Cra- nia Anat. Med. Chirur., 4to, Amstel., 1721, pp. no, 158, 156, 173-4, an d 163 respectively. (In the Library of the College of Physicians.) a Portal, Hist, de 1'Anat., torn. iii. p. 262. 3 Life of Peter the Great. London, 1832. 3* 3 EARLY HISTORY OF whom he tapped died soon after, but the Czar, by way of consolation, attended the funeral. On his return to Ley- den, in 1717, he purchased Ruysch's museum for 30,000 florins, and sent it to St. Petersburg. Ruysch, though seventy-nine years old, immediately went to work on another. When his son, his efficient assistant, died, in 1727, he pressed his two daughters into the work, and so diligent had he been that after his death, in 1731 (set. ninety-three), his second museum was sold to Stanislaus, King of Poland, for 20,000 florins. 1 1 These are the statements generally made as to their disposition on the authority of Burggrseve, Precis de 1'Hist. de 1'Anat., Gand, 1840, pp. 295-6. Hyrtl states (Zerglied., p. 592, note) that Heister asserts in the Preface to Vater's Museum Anat. propr., Helmst., 1750, that the second museum was bought by Fred. Aug. I., Elector of Saxony, from Ruysch's heirs, and carried to Dresden. Fred. Aug. II. sent it to Wittenberg, and Vater, Ruysch's pupil, then Professor of Anatomy in the University, made a catalogue of it (Regii Mus. Anat. August Catal. Univ. Vittebergse, 1736). Haller (Bibl. Anat., torn. ii. p. 43) says of this collection: " Aliquse partes carp, hum. ex Ruyschii thesauris coemtse, aliqua undique collecta." The question is often asked, "What became of Ruysch's prepara- tions?" Conflicting statements are made, some stating they exist at the present day in perfect preservation. (Bayle et Thillaye, vol. ii. p. 85, Par- son's Anat. Prep., Pref., p. v.) I am glad, therefore, to be able to give so valuable an opinion as that of Prof. Hyrtl, which being founded on per- sonal observation is both interesting and decisive. He says (Zerglied., pp. 593-3). " Ruysch's fame outlasted his collections, and the many preparations which he expected to preserve, ' per liquorem suum balsamicum seternos in annos 1 , no longer exist. In the Leyden Anatom. Museum Prof. Hal- bertsma showed me a planta pedis which it is thought was injected by Ruysch. In the Greifswald Museum I saw two others which, it is asserted, are Ruysch's injections. They came from Vater's private collection (" Mus. Anat. prop." above). The preparations sent to him by Ruysch (with whom he was in uninterrupted relations) are especially noted as such. After Vater's death the collection passed into the hands of his successor Langguth.andat the dissolution of the University of Wittenberg was bought by an apothecary for the glass ! By him a part vyas sold to Prof. Schultze, in GrciLwakl, when travelling through Wittenberg. In the Museum at PRACTICAL ANATOMY. 31 What in Ruysch's time was a profound secret, is in our day a common art. By the help of many workers in the same field 1 our means of injection are greatly increased, Prague, also, I found three small preparations an injected finger, a piece of intestinal mucous membrane, and a child's hand whose mode of pres- ervation so exactly corresponded with that in Ruysch's Thesaurus Ana- tomicus that they are most likely the work of this masterhand, and were probably among those collected by Du Toy, Prof. Anatomy at Prague in the first half of the last century, in his scientific tour in the Netherlands. Even in the Vienna Museum, according to Schwediauer, towards the end of the last century some of Ruysch's preparations were to be found. Those at Prague I have examined, and found them entirely worthless." On page 595 he speaks of them as "scarcely to be recognized as injections of the vessels," and of the " ruined specimens in Greifswald and Prague . . . which through long continuance in spirit (liquor balsamicus) are brittle, and by the development of the fatty acids are discolored and reduced to a grayish-brown and crumbling pasty mass (Teig) extrava- sation everywhere." The Russian collection, howevrt', Hyrtl seems not to have examined, and it is with pleasure, therefore, that I can state both on the authority of a letter from E. Schuyler, Esq., of the U. S. Legation at St. Petersburg (see the letter in the Phila. Med. Times, Feb. i, 1872, p. 173), and another private letter from Prof. Pelechin, Assist. Prof. Surg. in the Imperial Med- ical School of St. Petersburg, that Ruysch's cabinet forms at the present time part of the Anatomical Museum of the Imperial Academy of Sci- ences, and is in an excellent state of preservation, the injections being per- fect. Unfortunately, a small piece of a foetal intestine sent me by Prof. Pelechin for microscopical sections was destroyed by the carelessness of a third person. It was perfectly preserved, and looked very like a success- ful vascular injection. 1 Restricted as I was in time, I was unable to develop many points as I would gladly have done had time allowed. The principal cultivators of the art of injections since Ruysch are as follows : Alex. Monro primus added the stopcock to the injecting tubes, and used double injections, viz., glue to fill the finer vessels, followed by wax for the coarser. None of his preparations remain even in Edinburgh. Hyrtl, Zerglied., p. 599. Lieberkuhn (Berlin, 1711-46) was the first whose injections really stood the test of the microscope, and are worthy of comparison with the prepa- rations made at present. Sixty-six of them are in the Vienna Museum, each in the focus of one of his simple microscopes which are attached to the slides. He first made the joint between the syringe and the arterial 3 2 EARL Y HISTOR Y OF and our results, though to the eye they do not reach those popularly ascribed to Ruysch, yet for diffusing the knowl- edge of anatomy among the profession, and for anatomi- cal and microscopical research, they are vastly better. In- jections of plaster of Paris, 1 wax, paint, glue, 2 ether, and rubber every one can now make, and the wonderfully beautiful results of Hyrtl, Gerlach, Beale, and Thiersch are only equalled by the ingenuity of Chrzonszczewsky, who has recently effected the physiological injection of the bile-ducts by coloring the bile and then tying the hepatic duct. Bidloo, in Amsterdam, in 1685, and Cow- per and Nicholls, of Oxford, 3 a little later, added to our tube air-tight by means of friction instead of a screw. The wings by which it is now held were as yet unknown, and were replaced by a hook. He used wax, resin, turpentine, and cinnabar. Hyrtl, op. cit., p. 602. In the present century, Shaw's "cold paint injection" (see Parson's Anat. Preps., pp. 2-3, and Horner's Pract. Anat., Introd., pp. xviii. and xix., where this is attributed to Allan Ramsay) has been largely used. Bowman's double cold injection by acetate of lead followed by chromate of potash, both in solution, Voigt's solution of glue, Gerlach's of carmine, Beale's of Prussian blue, etc., have all been admirable. No one has done more to advance the art than Hyrtl himself, who was the first to make preparations of two, three, and four different colored injections, and has left no kingdom, family, or genus whose anatomy is not illustrated by his splendid researches. No medical man should visit this city without inspecting the splendid collection of his injected, and especially his cor- roded, preparations, recently purchased (1874) by the College of Physi- cians for the Mutter Museum. They are the most superb specimens of anatomical preparations I have ever seen. 1 First used by Trew (Commerc. Liter. Noricum, 1732, p. 298), and now in use generally in this country and in Berlin, while wax in various forms and combinations is used in Edinburgh, London, Heidelberg, Paris, Vienna, etc. First used by P. S. Rouhault, Surgeon to the King of Sardinia, 1718. Hyrtl, Zerglied., pp. 589-90. 3 Wm. Hunter (Introd. Lect., p. 56), and following him most other Eng- lish writers (e.g., Gold-headed Cane, p. 129; Horner's Anat., Introd., pp. xiv.-xv., note), give the sole credit of this beautiful invention to Prof. PRACTICAL ANATOMY. 33 means of illustration by injecting the vessels and hollow viscera with wax or metal, and then corroding or macerat- ing the animal textures, leaving the injection as their per- fect representative. Auzoux's splendid models have won for him the cross of the Legion of Honor. 1 Suchet, about 1850, revived the Egyptian method of tanning, but, unfor- tunately and wrongfully, kept the process a profound secret. In 1867, at the Paris Exposition, in noble contrast to this illiberal spirit, Brunetti, of Padua, explained to the Paris Medical Congress, in the crowded amphitheatre of the Ecole de Medecine, his method of tanning by which he had made the astonishing preparations which he then ex- hibited. For durability, preservation of form and struc- ture, both anatomical and pathological, even to microscopic exactness, they are unrivalled, and he was rewarded with a special gold medal, as well deserved as was the applause his liberal spirit elicited from an appreciative audience. 2 Still later (1873), Dr. Marini, of Naples, exhibited at the Nicholls. Hyrtl, however, places the credit further back and of right with Bidloo (Anat. Corp. Human., Amstel., 1685), who injected melted bismuth into the lungs, and Cowper (The Anat. of Human Bodies, Oxford, 1697), who used lead (Hyrtl, Zerglied., p. 604). Possibly Nicholls was the first thus to prepare the vessels. 1 Plastic models are now made by Auzoux with great beauty and exact- ness, and the history of their development may be found hi the New Amer. Cyc., first ed., vol. i.pp. 517-8, and vol.'ii. p. 409. In 1823, in the re-organi- zation of the universities to get rid of the materialism of the French Revo- lution, the old prejudices against dissection were revived. In consequence of the difficulties thus thrown in the way of dissection, it occurred to Auzoux, in 1825, to make models in papier-mache. In 1830 the invention was per- fected, and Auzoux now employs from sixty to eighty hands in his manu- factory, and supplies the world with his models (of which he makes about two hundred), both in human, comparative, and vegetable anatomy. 2 See Med. News and Library, Jan. 1868. I have in my possession now two specimens of tubercle and cirrhosis of the liver, kindly sent me by Prof. Brunetti, which are witnesses to the excellence of his method. The color is, of course, destroyed by the alcohol and the tanning. 34 EARLY HISTORY OF Vienna Exposition some anatomical preparations made by some new methods (which he also wrongfully keeps secret), which, it is asserted, after ten years, retain all their original freshness and natural appearance even to the fatty tissues. The body of Thalberg has been thus preserved for the adornment of his widow's drawing-room. 1 Dissections having for their object such permanent prepa- rations cannot be made in haste. They require consider- able time. So too dissections for a series of lectures on various systems, such as the muscular, the vascular, etc., require that we shall be able to preserve the body unless we go back to the short courses of bygone days. Thus, in Edinburgh, in 1697, in the first course of public lectures, as the felon's body by law had to be buried in ten days, ten lectures were delivered on successive days by as many- different lecturers, in which the entire subject was treated. How hurried the course was we may judge, seeing that on one day the brain, spinal cord, and all the nerves were fin- ished, and on another, all of the five senses. 2 But when we go back to Mondini in 1315, we find him the embodi- ment of brevity, for he completed the anatomy, physi- ology, and surgery of the entire body in five lectures. The first example we have of the use of preservative 1 Med. News and Library, Nov. 1873, p. 183 ; Med. Times and Gaz., Sept. 6, 1873. a Edin. Med. Journal, Oct. 1866, p. 294. The meagre number of lec- tures on important branches in later times also is striking. Thus, Mr. Bronfield, of St. George's Hospital, delivered but thirty-six lectures on anatomy and surgery, Dr. Nicholls, William Hunter's teacher, lectured on anatomy, physiology, pathology, and midwifery in thirty-nine, and Mr. Nource, at St. Bartholomew's, embraced " totam rem anatomicam" in twenty-three lectures. (John Hunter's Life, p. 4, note.) William Hunter enlarged the number of lectures on anatomy alone to eighty-six, about the present length of such a course. PRACTICAL ANATOMY. 35 means is in the now familiar Egyptian mummies. Be- lieving in the immortality of the soul, and that they could retain the soul within the body so long as its form was preserved entire, it was very natural that the Egyptians should endeavor to do by art what nature showed them to be possible in the desiccated mummies of the deserts around them. Various methods were adopted, of which we have a short description in the embalming of Jacob's body in Gen- esis, 1 and at a greater length in Herodotus and Diodorus Siculus. Three principal modes existed, differing chiefly in expense. The cheapest was available to even the poor, the second cost about $450, and the third about $1250." In the last, having removed the brain and its membranes through the nostrils, by breaking through the ethmoid bone with a curved piece of iron, they made an incision of five inches in the loins, removed the thoracic and abdominal viscera, cleansed them with palm wine and aromatics, and, after a prayer by the priest that all the sins of eating and of drinking might be forgiven, cast them into the river. 3 The abdomen was next filled with every sort of spicery except frankincense, and the body placed for forty days in natrum, an impure carbonate of soda. The heart embalmed apart, having been placed between the thighs, the whole body was then wrapped in cere-cloths with all the exactness of our modern spiral and reverse bandages, and sealed up with wax or bitumen, 4 and in some cases even gold was used. 5 Bitumen in many instances was used in the body 1 Gen. 1. 2, 3. 2 Rawlinson's Herod., vol. ii. pp. 119, 120, and notes. 3 Pettigrew's Hist, of Egyptian Mummies, London, 1834, p. 58. 4 Rawlinson's Herodotus Hist., ii. $ 136, and Diodorus Siculus, Bk. I. vol. i. p. 102, xcii. 5 One was found in Siberia, wrapped in forty pounds of gold. Petti- grew, op. cit., p. 65. 3 6 EARL Y HISTOR Y OF itself. In case the usual means were wanting, honey was used as the sole preservative, as in the case of Alexander the Great. 1 Some seem to have been preserved by tan- ning, and then enveloped in wax. In fact, the very name of mummy 2 is supposed to be derived from the Arabic "miimmia," from "mum," "wax." 3 1 Statius, lib. Hi., Carm. ii., v. 117. Pettigrew, op. cit., p. 86. King Aristobulus' body was similarly preserved. Josephus , Antiq. , lib. xiv. c. vii. 2 Rawlinson's Herod., vol. ii. p. 122, note. 3 William Hunter, at the close of each session, usually devoted one lec- ture to teaching his students how to make preparations, and described also a process in imitation of the Egyptian method, which he had put in use. In the case of the wife of Martin Van Butchell (whose body is now in the Royal College of Surgeons) his success was very good, and her husband's own account of it is such a curious document that I give it below. Not satisfied with preserving this treasure, he soon solaced himself with a second wife : " 14 Jan. 1775. At 2\ this morning my wife died. At 8 this morning the statuary took off her face in plaster. At half-past 2 this afternoon Mr. Cruikshank injected at the crural arteries, 5 pints of oil of turpentine mixed with Venice turpentine and vermilion. " i$th. At 9 this morning Dr. Hunter and Mr. C. began to open and embalm the body of my wife. Her diseases were a large empyema in the left lung (which would not receive any air) accompanied with pleurisy and pneumonia and much adhesion ; the right lung was beginning also to decay, and had some pus in it. The spleen hard and much contracted ; the liver diseased called Rata Malpighi. The stomach very sound. The kidneys, uterus, bladder, and intestines in good order. Injected at the large arteries, oil of turpentine mixed with camphored spirits, i.e. 10 oz. camphor to a quart spirits, so as to make the whole vascular system tur- gid ; put into the belly part 6 Ibs. rosin powder, 3 Ibs. camphor powder, and 3 Ibs. of nitre powder mixed with rectified spirits. " I7th. I opened the abdomen and put in the remainder of powders and added 4 Ibs. rosin, 3 Ibs. nitre, and i Ib. camphor . . . " i8th. Dr. H. and Mr. C. came at 9 this morning and put my wife into the box, on and in 130 Ibs. wt. of Paris plaster, at 18 pence a bag. I put between the thighs, 3 arquebusade bottles, one full of camphored spirits very rich of the gum, one containing 8 oz. of oil of rosemary, and in the other 2 oz. lavender. PRACTICAL ANATOMY. 37 The mummies have been put to some curious uses. The Egyptians gave them as pledges for the repayment of bor- rowed money, 1 the "hypothecated bonds" of the Alex- andrian "Bourse." But in the middle ages they were still more curiously employed, as potent remedies in falls, bruises, and other external injuries. "Mummy," says Sir Francis Bacon, "hath great force in staunching of blood, which may be ascribed to the mixture of balms that are glutinous." Francis I. always carried with him a little packet of powdered mummy and rhubarb for falls and other accidents. 2 So great was the demand that as the real article was difficult to obtain, like Waterloo bullets, they were manufactured at enormous profits by avaricious Jews in Alexandria. Ambroise Pare, who was born in 1509, in his book on the mummy, 3 states that having " igth. I closed up the joints of the box lid and glasses with Paris plaster mixed with gum water and spirits of wine. " 25th. Dr. H. came with Sir Thomas Wynn and lady. " Feb. 5. " Dr. H. came with 2 ladies at 10 this evening. " 7th. Dr. H. came with Sir Jno. Pringle, Dr. Herberden, Dr. Watson, and about 12 more Fellows of the Royal Society. " nth. Dr. H. came with Dr. Solander, Dr. , Mr. Banks, and another gentleman. I unlocked the glasses to clean the face with spirits of wme and oil of lavender. " I2th. - Dr. H. came to look at the neck and shoulders. " I3th. I put 4 oz. camphored spirits into the box at the sides and neck, and 6 Ibs. of plaster. ' ' i6th. I put 4 oz. oil of lavender, 4 oz. oil of rosemary, and i oz. oil of chamomile flowers (the last cost 4 shillings) on sides of the face, and 3 oz. of very dry powder of chamomile flowers, on the breast, neck, and shoulders." The body resembles a Guanche mummy rather than an Egyptian, and is, properly speaking, a desiccated rather than an embalmed body. Petti- grew, op. cit., p. 258, note. 1 Pcttigrew, op. cit., pp. 16 and 17. 3 Pettigrew, op. cit., p. 9. Even to-day they are used by the Arabs mixed with honey (p. 12.). 3 The Workes of that famous Chirurgion, Ambroise Pare, London, 4 38 EARLY HISTORY OF learned this fact from his friend De la Fontaine, who had observed it in Egypt, and also having never seen any good effect from the remedy, .he did all in his power to dis- courage its use both in his own practice and also in all his consultations. He gives us too, in his book on embalm- ing, a method he himself used for the preservation of a body, with very gratifying success, and as it is the earliest of the more modern methods, I will give its quaint and curious details and results. 1 "The body which is to be embalmed for a long con- tinuance must first of all be emboweled, keeping the heart apart that it bee embalmed as the kinsfolkes may thinke fit. Also the braine, the scull being divided with a saw, shall be taken out. Then shall you make deepe incisions alongst the armes, thighes, legges, backe, loynes, and but- tockes, especially where the greater veines and arteries runne, first, that by these meanes the blood may be pressed forth, which otherwise would putrifie, . . . and then that there may be space to put in the aromaticke powders. The whole body shall be washed over with a sponge dipped in aqua vitae and strong vinegar, wherein shall be boiled wormewood, aloes, coloquintida, common salt and alum. Then these incisions and all the passages and open places of the body and the three bellys shall be stuffed with the following spices grossely powdered : R. Pulv. rosar., chamomil. melil. balsam, menthae, aneth. saluise, lauend. rosism. maioram. thymi, absinthii, cyperi, calami aro- matici, gentianae, ireos flor. assas odoratae, caryophyll. nucis moschatae, cinnamomi, styracis, calamitae, benioini, myrrhre, aloes, santal. (with exquisite indefiniteness), quod 1649, p. 332. I cannot refrain from giving the capital pun on his name in the motto which is under his portrait in the frontispiece. " Humanam Ambrosii verehaec pictura Parasi, effigiem, sed opus continet ambrosiam." 1 Op. cit., pp. 1130-2. I PRACTICAL ANATOMY. 39 sufficit. Let the incisions be sowed up, and forthwith let the whole body be anointed with turpentine dissolved with oyle of roses and chamomile. Then wrap it in linen cloath and ceare cloaths. I put in mind hereby, that so the em- balming may become more durable, to steepe the bodys in a woodden tubbe filled with strong vinegar and the decoction of aromaticke bitter things, as aloes, rue, colo- quintida, and wormwoode, and there keep them for twenty days, pouring in thereunto eleven or twelve pints of aqua vitsei ' ' Alcohol is the real means, you will observe. And now for the result. "I have at home the body of one that was hanged, which I begged of the sheriff, embalmed after this manner, which remains sound for more than twenty-five yeeres, so that you may tell all the muscles of the right side (which I have cut up even to their heads, and plucked them from those that are next them for dis- tinctions sake, that so I may view them with my eyes and handle them with my hands, that by renuing my memory I may worke more certainely and surely when as I have any more curious operations to be performed). The left side remains whole, and the lungs, heart, diaphragma, stomache, spleene, kidneyes, beard, haires, yea, and the nailes, which being pared (he adds with charming naivete), I have often observed to grow again to their former big- nesse." A century later than Pare, Ruysch, as we have seen, was said to have the most astonishing means for the preser- vation of his subjects. But we must make large allowances for the natural exaggeration of the extremely happy results of what was then a new art. Nor should we be the better off did we possess the secret of his contemporary De Bilsius, a noted charlatan of Rotterdam, whose boasted method, Haller says, was bought by the States of Brabant for the enormous sum of 122,000 florins, or more than four times 4 o EARL Y HISTOR Y OF the price of Ruysch's first museum. The bodies he pre- tended to embalm for the University of Louvain were soon destroyed, and, apparently in proof of the inefficacy of his own method, so foul was the air of the rooms in which he prepared his subjects, that it was said to have been the cause of the consumption to which he fell a victim. 1 The traveller in Europe to-day finds a number of speci- mens of bodies preserved either by art or by nature, curious alike to the antiquary and the anatomist. In Milan is the body of St. Carlo Borromeo, who died in 1584; on the Rhine, near Bonn, in an old monastery, lie over a score of monks in cassock and cowl, placed in its vault before Columbus had discovered the New World ; and again, in the church of St. Thomas, at Strasburg, are seen the bodies of the Count of Nassau and his daughter, over six hundred years old. The skin is yellow and shrivelled, but perfectly preserved ; the small clothes of the father have been re- placed by imitations, but the clothes of the daughter are intact. The lace on her blue gown is perfect, bunches of silver flowers adorn her hair, jewels lie on her breast, and even diamond rings clasp the shrivelled fingers as in mockery of death. All of these have been probably pre- served by the aluminous soils in which they were placed. Cold has done the same work for the ghastly remains in the morgue on top of the great St. Bernard, while desic- cation has shrivelled both features and limbs into con- tortions worthy of purgatory. The largest collection of bodies preserved, not by nature, but by art, and by the simplest method, namely, that of desiccation by means of artificial heat, is in the monastery of the Capuchins, near Palermo. All its in- mates who have died for the last two hundred and fifty Bayle et Thillaye, op. cit., vol. ii. pp. 84-5. PRACTICAL ANATOMY, 41 years, more than two thousand in number, stand upright in ghostly companionship in the niches of its subterra- nean galleries. 1 None of these means, however, would do for dissection. For practical anatomy the introduction of alcohol 2 with- out the numerous drugs that Pare used, was the first efficient means which rendered patient and prolonged dissection available, and Cuvier points to its use as an indispensable step in the progress of comparative anat- omy, as it rendered possible the preservation of animals while being transported from distant parts of the world. Since then chemistry has added largely to our means for such purposes, such as chloride of zinc, arsenic, salt, and nitre, hyposulphite of soda, acetate of alumina, and other means for special purposes. In Berlin, Heidelberg, Vienna, etc., alcohol is used where a prolonged dissection is neces- sary ; but for the ordinary dissections of students nothing whatever is used. The greater number of unclaimed bodies, arising from overcrowding, poverty, and want, so amply supplies the anatomical schools that they dissect without any antiseptic, and remove the subjects the moment decomposition sets in. In Vienna no part is allowed to remain on the tables more than seven days. But' while such an arrangement would be disastrous here, 1 The reader who is curious in such things will find many other such instances described in full in Pettigrew's Hist. Egypt. Mummies, and in Harlan's Gannal's Hist, of Embalming, 8vo, Philada., 1840. Among them are not only full accounts of the Egyptian mummies, but also of those of Peru, Mexico, the Guanches, etc., and of the bodies preserved at Bordeaux, Toulouse, etc. Dr. A. B. Granville's " Essay on Egyptian Mummies," Phil. Trans., 1825, p. 969 efsey.,a\so contains some interest- ing facts, including a case of ovarian disease discovered in a mummy. a Abucasis in the twelfth century first showed how to get spirits from wine. Raymond Lully (thirteenth century) first dehydrated it by carb. potass. Gmelin's Handb. Chem., vol. viii. p. 194. 42 EARLY HISTORY OF it works well there by reason of their different mode of study. The dissecting-rooms are only open from twelve noon to seven P.M., and from October to April; but during the first two years the student does but little beyond dissection and the study of anatomy. In this country, where the supply of material never equals the demand, especially in the winter, we are com- pelled to preserve them for months. The chloride of zinc and arsenic are the favorite means. 1 By such a hasty review as I have now given of the imperfect methods, the meagre advantages, and the re- stricted opportunities for the cultivation of practical anatomy by former students of medicine, we can appre- ciate how vastly better off we of to-day are from every point of view. The good old times are the myths of croakers with which they would repress the progressive spirit of the present. Never has anatomy made so rapid and so substantial progress as in the present century, and never has it in this country attained such a point as it occupies to-day. Yet we lack much. Our very wealth of opportunities threatens us with a Capuan repose, unless the stirring examples of the great men who have pre- ceded us stimulate us to exertion. Tertullian says that Herophilus, in Alexandria, dissected over six hundred bodies. 2 Berengarius, of Carpi, the contemporary of Vesalius, dissected over one hundred. 3 Haller, who died 1 For some researches of my own with a new preservative hydrate of chloral see the Philadelphia Medical Times, March 21, 1874, " On the Anatomical, Pathological, and Surgical Uses of Chloral." My subsequent experiments have fully borne out the conclusions there stated. They will be given at length in a subsequent paper. 2 Encyc. Brit., vol. ii. p. 751. Wm. Hunter, Introd. Lect., p. 19. 3 Bayle et Thillaye, op. cit., vol. i. p. 244. PRACTICAL ANATOMY. 43 a century ago, says that with his own hand he had dis- sected over four hundred in seventeen years ; x and that almost unequalled worker, John Hunter, when asked at the trial of Captain Donellan, in 1781, whether he had not dissected more than any other man in Europe, re- plied, "In the last thirty-three years I have dissected some thousands of bodies." 2 It seems an exaggeration; but remember his habits. For thirty years his working- day consisted of nineteen to twenty hours. He rose at lour or rive o'clock, and always dissected till his breakfast hour, at nine, and after his labors in pmrJJre and the hospital- wank were aver, his labors in the dissect room re-comrhehced, and he never left it "till midnight even later. When any of you, then, visit the Hunterian Museum, in London, remember what it cost him in money, and, what is more, the unceasing labor of a long life. Such diligence has sometimes, alas ! cost the world more than money or toil. It cost the life of Bichat, who died at barely thirty-one from constant confinement in his dissecting-rooms. "Bichat," wrote Corvisart to the First Consul, "has just died on a field of battle that counts more than one victim. No man in so short a time has done so much and so well." 3 Joining diligent work to the unequalled opportunities that we now have, the laborers in the vast field of medi- cine, in whatever department they toil, will meet with a reward never before equalled. The future opens to the active worker the brightest prospects. Happy will he be who knows how to avail himself of its advantages ! 1 Encyc. Brit., 8th ed., vol. ii. p. 715. 2 Life, vol. i. p. 134. 3 Bichat sur la Vie et la Mort, p. xiv. 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