LEUCORRHCEA AND OTHER VARIETIES OF GYNECOLOGICAL CATARRH A TREATISE ON THE CATARRHAIv AFFECTIONS OE THE GENITAI, CANAI. OE WOMEN ; THEIR MEDICAI. AND SURGICAI, TREATMENT. BY HOMER IRVIN OSTROM, M. D. NEW YORK Surgeon to the Metropolitan Hospital Surgeon to the Hahnemann Hospital Senior Member of the American Institute of Homoeopathy; Member of the New York State Homoeopathic society; Homoeopathic Medical Society of the County of New York; Member of the Academy of Pathological Science; American Obstetri- cal Society; Surgical and Gynaecological Associa- tion; Fellow of the Medico Chirurgical so- ciety; Fellow of the British Gyneco- logical Society. AUTHOR OF A Treatise on the Breast and Its Surgical Diseases Epitheliofna of the Mouth The Diseases of the Uterine Cervix PHILADELPHIA, PA.: BOERICKE & TAFEL 1910 COPYRIGHTED BY BOERICKE & TAFEL 1910 PREFACE. Many of the minor diseases peculiar to women are associated with disorders of the mucous membrane that lines the genital canal, but we are rather inclined to disre- gard these affections in favor of operative gynaecology, and for the development of sur- gical technique. This class of disease, how- ever, merits careful consideration, not only because of its primary importance, but on ac- count of its significance as an etiological factor in more serious maladies. The commonly used term, leucorrhoea, sig- nifies only one form of catarrh— a milk}^ white flow — and is, therefore, not compre- hensive enough to embrace every variety of mucous discharge, while catarrh, used in the same sense as when applied to other mucous membranes, conveys a more accurate under- standing of the pathology and clinical his- tory of the gynaecic mucous membrane dis- ease. Specific catarrh is not included, for the reason that it constitutes a special class of disease, that requires special treatment. IV PRE^FACi:. The classification of gynaecological ca- tarrh here adopted is based upon the char- acter of the discharge. Such a grouping is not entirely satisfactory, but the anatomical divisions of the genital canal, which in health are clearly defined, become blurred in dis- ease, and in consequence cannot be relied upon for classification; and, moreover, no form of gynaecological catarrh belongs to any one period of life, and, therefore, the clinical history alone cannot be relied upon for this purpose. Part IV., dealing with Therapeutic Sug- gestions, includes a repertory, and is, as its name implies, merely suggestive. No at- tempt is made to record more than the actual symptoms of catarrh, with a few concomi- tants and generalizations. Because of the lack of exactness in recording symptoms, it has in some instances been found difficult to distinguish catarrh from the discharge of a malignant disease, or neoplasm, but such conditions have been eliminated as much as possible. 130 West ^yth Street, New York City. November, ipio. CONTENTS. Preface V Chapter I, Anatomy of the genital canal i Physiology of the parts especially involved in catarrh 13 Function of the mucous membrane 16 Chapter II. The nature of catarrh in general 18 The causes of gynaecological catarrh 20 Infection 21 Constitution 22 Mechanics 23 Exanthematous diseases 24 Chapter III. Classification of Gynaecological Catarrh zy Simple catarrh 28 Infants and children 30 Treatment, local 31 Adults 36 Treatment, local , 2)1 medical 42 Young girls 43 Mucopurulent catarrh (leucorrhoea) 44 Adults, children 46 Treatment, local 57 constitutional 62 medical 6S VI CONTENTS. Purulent catarrh 7j Senile purulent catarrh 76 Treatment, local So operative 82 curettage 8S trachelorrhaphy 90 constitutional 03 medical 94 Sanguineous catarrh 94 Treatment, medical 99 Senile catarrh loi Treatment loi Chapter IV. Part I. Suggestive therapeutics 105 Part II. Repertory 145 Index 20^ LEUCORRHOEA. CHAPTER I. ANATOMY 01^ THK GENITAI, CANAI, PHYSI- OIvOGY OF TPIi: PARTS i:SPi:CIAI,IvY IN- VOLVED IN CATARRH — FUNCTION OF THE MUCOUS MEMBRANE. The genital canal, the part immediately in- volved in gynaecological catarrh, is in the form of two opposing angles, the vertical line of union extending from the vulva to the fundus of the uterus, the horizontal lines to the fimbriated openings of the Fallopian tubes. These passages are lined throughout with mucous membrane, the epithelium and construction of which are variously modified to meet physiological uses. The anatomical divisions of the canal, with which gynaecological catarrh is con- cerned, are, from without inwards, the vulva, the vagina, the portio- vaginalis, the os uteri, the cervix uteri, and the Fallopian tubes. 2 I^KUCORRHC^A. The frame-work of the uro-genital sys- tem, of which the genital canal is a part, is developed from the embryonal glands — the Mullerian ducts. These organs, two in nurfi- ber, by fusing, the process begins in the third month, and the septum thus made is not completely removed until late in the eighth month, form the uterus and vagina, the Fallopian tubes representing the por- tions of the Mullerian ducts that remain in- tact. The Mullerian ducts are developed in the mesoblast, the middle or intermediate layer of the blastoderm, from which they derive their connective tissue and muscular super- structure, but by a process of invagination of the hypoblastic layer of the coelum they receive a covering of mesothelial cells which ultimately furnishes the entire genital canal with a mucous membrane. Beyond the fact that in some parts, not- ably the corpus uteri, where the arrange- ment of lining membrane is unlike that of any other mucous membrane, for here the glandular layer is directly adherent to the subjacent muscular is, and there is an absence GOBLKT CE:i,I,S. 3 of any intervening connective tissue sub- tratum or submucosa, the mucous membrane of the genital canal does not differ materially from mucous membranes generally. This tissue, the use of which is to furnish a protective covering for internal parts that communicate with the surface of the body — an internal skin — is built upon a simple plan, epithelial cells and a supporting structure, with epithelial invaginations that form glands having a simple, rarely a racemose arrangement. These glands are irregularly distributed, but while they secrete mucus they cannot be regarded as an essential part of mucous membrane architecture; for the function of mucous elaboration is also per- formed by the epithelial cells — goblet cells — which characteristic distinguishes them from all other cell bodies. The supporting structure or corium is composed of connective tissue intermingled with lymphoid tissue. Between this and the epithelium is usually found a basement mem- brane composed of flattened cells which fol- low all the inequalities of the mucous mem- brane, where it aids in the formation of the 4 . I^DUCORRHC^A. gland walls. Beneath this is a layer of thin non-striated muscular tissue, which forms the deepest part of the mucous membrane. This, however, is not always present. Mucous membranes are always abundant- ly supplied with blood vessels. The arteries and veins divide in the submucous tissue, sending a network of capillaries to the corium, where they lie immediately below the epithelial layer. The glands with which the genital mucosa is liberally supplied, are irregular in distribu- tion and arrangement, some parts of the canal, for example the portio-vaginalis, be- ing wholly devoid of them. The simple folli- cles are lined with the same variety of epi- thelium that invests the mucous membrane in which they are situated, and open perpen- dicularly to the surface upon which they pour their peculiar secretion. When present at all they are very numerous, as in the upper two-thirds of the cervical canal, where it is estimated there may be at least ten thousand of these minute bodies. No glandular structures exist in the corpus uteri at birth, these formations are i:pithi:i,iai:, ce:i.i,s. 5 entirely post-embryonic. Nor do they ap- pear as more than fissures made of the folds of the mucous membrane before the general change that ushers in puberty; when coinci- dent with that organic evolution the fissures assume a glandular form and develop in great numbers, a process that is repeated and passed through with each subsequent men- struation and pregnancy. On the basement membrane rests a layer of epithelium. Its cells, which are derived from the hypoblast of the blastoderm, are to be looked upon as the essential part of all mucous membranes. Like other epithelial cells they are transitory, and only assume their characteristic form subsequent to evo- lution. Not all the cells that make up the epithelial covering of the mucosa are mucous forming bodies. Squamous cells which appear more abundant in the region of external openings do not assume this function, but in these parts mucous glands are more numerous, and the protective material is supplied in sufficient quantity by them. The epithelial covering of mucous mem- 6 i,i:ucorrhce:a. brane is highly permeable, especially where squamous epithelium predominates. In these situations lymphoid tissue is more abundant, and lymphoid elements in the form of mucous corpuscles escape from the reticu- lar structures. The epithelial cells of the genital canal vary in type according to location, but under the demand of physiological requirements, or pathological irritation, one form may assume any other form, and so obliterate normal structural boundaries. There are no well at- tested exceptions to the teaching that "cells breed true," but this law applies to the two great anatomical divisions, epithelial, and connective tissue — epiblastic and meso- blastic. An epithelial cell may change its form, indeed one of its chief offices is to harmonize in this respect with local require- ments, but that which distinguishes an epi- thelial cell from a connective tissue cell con- tinues with the integrity of the cell body. Beginning at the border of the labia major, the mucous membrane, which is here contin- uous with the skin but separated from it by a well marked line of structural differences. VAGINAI, MUCOUS MEMBRANE:. 7 passes over the nymphse and clitoris to be prolonged into the vagina and urethra. Up to the hymen, or its remains, the membrane is covered with scaly epithelium derived from the hypoblast, and liberally provided with mucous crypts and follicles, and with glands that secrete an unctuous substance. Sebaceous glands are especially numerous beneath the prepuce, upon the labia major and outer surface of the nymphae. But few, if any, mucous cells exist normally in this part of the genital canal, and, therefore, the substance with which the surfaces are bath- ed is derived chiefly from the glands, and lymphoid structures. The vagina, extending from the hymen, or urogenital diaphragm, to the ring in which the portio-vaginalis of the uterus rests, is lined with many layers of squamous epi- thelium derived from the epiblast. The mucous membrane being more ample than the underneath submucosa, is thrown into columns and rugae. Mucous glands are few in number, save in the smoother portions of the canal, the upper third of the vagina. They, together with mucous cells, bathe the 8 i,Kucorrhce:a. vaginal walls in an acid secretion, but the vaginal mucosa is otherwise structurally quite homologous to the skin. The mucous membrane is continued over the portio-vaginalis, which comprises all structures between the os externum and the vaginal fornices, or ring. It is covered with squamous epithelium, the cells of which se- crete an abundant acid mucus. The secre- tion of the portio, however, is not a true glandular product, as there are no glands in this region ; it results from the delequescence and shedding of the superficial epithelial cells, and the process by which the goblet cells give up their contents probably without destruction of their wall. The stratified epithelial layer of the vagina is continued with more or less dis- tinctness beyond the external os into the cer- vical canal, the lower third of which it lines. The upper two-thirds are lined throughout with a single layer of epithelial cells of cylin- drical type, the surface of the membranes be- ing studded throughout with the minute ori- fices of numerous glands. These, for the most part, simple follicles, secrete a thick, AI,KAI,INK SI:CRI:TI0N. 9 viscid alkaline mucus. Non-ciliated epithe- lium lines the follicles, the cylindrical cells of which undergo the mucous or calyciform change which belongs to the elaboration of their peculiar secretion. The characteristic ''goblet cells" are fairly numerous in the membrane covering this part of the cervical canal. The interior of the corpus uteri is covered with a single layer of columnar cells. The underneath membrane is much thicker than « the cervical membrane, its maximum thick- ness being found at about the middle of the cavity. Its surface is studded with an im- mense number of minute depressions, the openings of small tubular glands. These glands also elaborate an alkaline fluid, but it is devoid of the viscid properties of the cer- vical secretion. The epithelial cells differ from those lining the glands of the cervix, in that none of them present calyciform char- acters. A very marked difference exists between the time at which the glands of the corpus and cervix appear. At the beginning of the ninth month of gestation the epithelium of 10 * i,i:ucorrhce:a. the cervix begins to undergo mucous trans- formation, indicative of secreting activity. Numerous follicles also appear, and as a re- sult of activity the canal at birth is filled with a mucous plug, which effectually closes the interior of the uterus. Quite different is the history of the glands of the corpus, for, w^hile in the sixth month there are found traces of tubular involutions of the cylindrical cell lining membrane, which later developes into glandular struct- ures, no true functionating glands are found in the corpus at birth, these organs, as before stated, being post-embryonic. As puberty advances the development of glandular structures and of the calyciform epithelial cells progresses rapidly, and is re- stimulated at each menstruation, and gesta- tion, but at the climacteric obsolescence the process of secretion, both from glands and the mucous epithelial, begins to recede gradu- ally. The endometrium is changed, its cellu- lar elements disappear, and the activity that marked reproductive life is folded up and ceases. The behavior of the epithelial cells that MUCOSA OF UTERUS. 11 line the utricular glands is of especial inter- est in connection with the gynaecological ca- tarrh of senility. These glands should in health wholly disappear, and their function terminate with the completion of the meno- pause, but occasionally, under not always de- terminable systemic and local conditions, they degenerate and become pathological factors of moment to the clinician. The particulars in which the mucous mem- brane lining the body of the uterus differs from all other mucous coverings have gh en rise to doubts as to whether this should be classed among mucous membranes. As, however, the epithelial cells do assume caly- ciform characteristics, and the glands secrete mucus, the name does not seem to be misap- plied, even though there is an absence of sub- mucous tissues, and the glands are directly adherent to the subjacent muscular is. Pos- sibly it would be more accurate anatomically to consider this structure as lymphatic tissue, and its glands as pseudo-glands, as merely pits honey-combing the epithelial layer, but its function is that of a mucous membrane, and unnecessary confusion would follow a change of name. 12 i.e:ucorrhcea. Perhaps more than any other epitheHal cells those of the genital canal show a re- markable power of repair after remo\'al or injury. Curetting and operations on ihe vagina and cervix are followed by very rapid regeneration of epithelium. The mucous membrane lining the Fallo- pian tubes consists of columnar epithelium, connective tissue, and musculature. It is continuous with that of the uterus, but ac- quires a submucous layer at the beginning of the isthmus. The membrane is thrown into longitudinal folds which become more numerous in the direction of the ampulla. True glands do not exist in the mucous mem- brane of the Fallopian tubes. There is a honey-comb arrangement of the tubal epi- thelium, similar to that found in the uterus, but these are no more than depressions that impinge upon the submucous tissue. At the border of the fimbria exists the demarcation between the mucous membrane and the serous structure of the peritoneum. This point marks the anatomical limit of the ca- tarrhal diseases of the female genital canal. The physiology of the mucous membrane of gobi,i:t cDi^ivS. 13 the genital canal has been anticipated in the foregoing review of its anatomy. The really essential element, whether it fmictionates on the lining membrane or in a gland cavity, is the epithelial cell that has acquired the habit of elaborating mucus. While a corium of well recognized construction forms part of a typical mucous membrane, this is not indis- pensable, as attested in the lining of the uterine corpus ; nor are glandular bodies nee- essary to distinguish this tissue. The incentive for an epithelial cell to elaborate mucus can be none other than a re- sponse to a physiological demand, for it is not found that the columnar cells of the mucous membrane differ from other col- umnar cells until they undergo changes which convert them into goblet cells in the process of mucous secretion. Not all the cells that cover a mucous membrane undergo this change, for in health the larger number re- main simple columnar cells, but capable of becoming mucou° forming cells under the stimulus of physiological requirements or pathological contamination. The elaboration of mucus within the pro- 14 i,e:ucorrh<^a. toplasm of epithelial cells converts these bodies into goblet or chalice cells by the enormous distention of their walls with mucigen. The mucus is then discharged from the end of the cell, but the subsequent fate of the cell is uncertain, for it is not de- termined whether after being freed of its contents the cell is reconverted into an ordi- nary columnar cell, or whether it remains a goblet cell to be again filled wdth mucus, the acquired cell form and function remaining permanent. It is probable that the latter cycle is that of healthy secretion, but that under the incentive of disease — catarrh — the process being rapid, epithelial cells have not time to mature, and are cast off with the dis- charge, their places being taken by newdy formed bodies. Such imperfectly emptied goblet cells are frequently found mingled wath the mucous and lymphoid elements of both acute and chronic catarrh of the genital canal. Reference has been made to the alkaline reaction of the uterine secretion, and the acid reaction of that of the vagina. These prop- erties do not seem to depend upon a specializ- VAGlNAIv BACII^IvUS. 15 ing function of either the surface goblet epi- thelium, or that lining the mucous glands in loco. It is more likely that all mucus when secreted is alkaline, and that it becomes acid in the vagina owing to the presence of a special vaginal bacillus that in health, ow4ng to the cervical plug, cannot find its way into the uterus. The bacillus has a protective or antagonistic action upon pathogenic bacteria, which, though always present, cannot de- velop be3^ond the capacity of disposal as long as the normal standard of acidity is main- tained. Under conditions of infection, pa- thologic bacteria are met at the vulva by the acid secretion of the vagina, and if they chance to pass this sentinel the mucous plug at the OS acts as a further barrier against in- vasion of the uterus. During the period of lochial discharge the normal va 86 I/O INDEX. G. Calomel, the use of, as a dusting powder 84 Calyciform cells, the character of 9, 10, 13, 18, 28 Carbolic acid douche 41, 58, 60, 83 application of, to the cervix 59 Cascara, the use of, for the constipation of children. . 42 Cascara and maltine 63 Catarrh, acute genital 28 in children 3i> 43 chronic genital 28, 32 classification of 97 constitutional symptoms of 56 curettement for the treatment of 62 gynaecological 14, 18, 42 infection, the source of 32 the local causes of 20 muco-purulent , 44, 47, 49, 50, 54, 55 constitutional treatment of . . 62 local treatment of 57 reaction of 56 symptoms pf 56 purulent 27, 62, 72, 76 blood in y6 clinical course of 79 the color of 76 source of injection of 75 origin of 78 senile 96 treatment, constitutional . . 93 local 80 sanguineous 28, 94, 96, 97 the treatment of, in adults 99 the treatment of senile . .96, loi simple 18, 27, 28, 32, 36 treatment of general 41 of the uterus 45 INDEX. 171 Catarrh of young girls 21 Cautery, the actual, treatment of pruritus with 102 Cells, breed true 6 calyciform 9> ^o chalice 13 goblet 9, 10, 14 protoplasm of 18, 28 their methods of discharging mucus 14 immature, and genital catarrh 23 Cervical canal, alkaline reaction of the 8 dilatation of the 89 endometrium of the, in muco-puru- lent catarrh 49 the lining of the 8 Cervix, erosion of the 48* 75 treatment of, with Iodine .... 64 Children, catarrh in 28, 30 treatment 43 constipation in 42 the method of using the vaginal douche for 35 Churchill's tincture of Iodine, the action and use of 60 Cicatricial tissue after operations 102 Constipation in adults 42 children 42 * and gynecic diseases 63, 64 the treatment of 42 Constitution and vicious metabolism 23 the relation of, to mucous secretion .... 21 Corium, a layer of mucous membrane 3 glands of the, at birth 10 Corpus uteri, the lining of the 29 secretion of the 9 Creolin, the use of, for douching 81 Curettage 62, 87, 88, 89, 100 after treatment of 93 Curette, the use of the 89 172 INDEX. D. Diathesis, scrofulous and genital catarrh 23, 43 Discharge, the suspicious character of a bloody 99 Douche, bag and tip 38 the intra-uterine 87 Alum and Sulphate of Copper 59 Bichloride of Mercury 41 Bicarbonate of Soda 39, 58 Boracid Acid 32, 41, 99 Carbolic Acid 41, 58, 60, 83 Glycerite of Tannin 38 Hydrastis 81, 99, loi Iodine 58, 60, 81, 99 Lead Acetate 2>7 Permang. of Potassa 99 Sulphate of Copper and Alum 39 method of giving a 37 to children 35 the temperature of a 39 Dusting powders, objection to the use of 84 E. Ectropion of cervical mucosa 49 Eczema, ointment for 33 Endo-cervicitis 51 Endo-metritis, atrophic 97 hyperplastic 100 and purulent catarrh 75, 79 sanguineous catarrh 95 Epithelial cells, chalice 13 calyciform 9, 10 cylindrical 19 of genital canal 12 goblet 9, 10, 14 INDEX. 173 Erosion of the cervix 48, 51 Exanthemata, suppressed 43 Exanthematous diseases, and genital catarrh 29 of children 29 F. Failure, the causes of, after curettage and trachelor- rhaphy 88 Fallopian tubes, catarrh of the 'j'j epithelium, of the 12 glands of the 12 in purulent catarrh yz reaction of the secretion of the .... 16 tuberculosis of the 78 Fluors alba 36 Ferguson's speculum 83 G. Genital canal, development of the 2 lining of the i mucosa of the 2 shape of the 7 Gestation, arrest of, a cause of leucorrhoea 52 appearance of mucosa during 9 changes in mucosa during 10 Glands, of Bartholin 29, 73 genital, development of the, in reproductive life 45 distribution of 4 of mucous membrane 4 utricular in health 11 Glandular hyperplasia 61, 62,83 Glycerine, the use of, in vaginitis 4^ Glycerite of Iodine 61 starch 34 Goblet cells, 18, 28, 39 formation of 13 protoplasm of 18 secretion of 8 174 INDEX. Gonococci in the vulva i6 Gonorrhoea! infection in purulent catarrh 74 Granules in vaginal mucous membrane in purulent catarrh 74 Gynaecological catarrh, complications of 25, 27 composition of 26 H. Headache, a symptom of muco-purulent catarrh .... 57 Hot Springs, a course at, in the treatment of genital catarrh lOO Hydrastis, fluid extract, douche 81 tampon 86 Hygiene, necessity for regulating 65 sexual 67 Hymen, epithelial covering of the 7 imperforate 34 I. Ichthyol vaginal tampon 62, 86 Infection, avenue of pelvic 88 conditions favorable for 17 leucorrhoea a mixed 41 immunity from 22 Iodine, bactericidal action of 61 Churchill's tincture 60 douche, vaginal 58, 60, 81, 99 douche, intra-uterine 87 and Glycerine 61 tampon 86 the use of, after curettage 90, 100 the treatment of glandular hyperplasia with 61, 80 L. Laceration of uterine cervix, causes of vicious healing 92 congenital i 52 INDEX. 175 Laceration of the uterine cervix, preparation for operating on the . .80, 83 in purulent catarrh . .75, 78 stellate 91 Lead acetate douche 37 Leucorrhoea 36 a mixed infection 41 Lochia, vaginal bacilli normally absent from the 15 Love, effects of disappointed 43 Lymphoid elements and tissues 6 M. Malignant growths, line of demarcation of 49 Masturbation, a cause of 30 Measles, a cause of genital catarrh 24, 29 Menopause, and sanguineous catarrh 97 Menstruation, changes in epithelial cells that attend . . 45 the establishment of, and sanguineous catarrh 98 genital glands during 10 Mercurius dulcis, the use of, for constipation 63 Metabolism, and genital catarrh 23 Microbes, the cause of catarrh 20 Micro-organisms of purulent catarrh 45 determine the differences between forms of catarrh 96 Mt. Clemens, the baths of 100 Mucous membranes, the blood supply of 4 construction of 3 epithelial covering of 6 essential elements of 13 parts of S the formation of genital 12, 16 the glands of 34 granules developed in the 74 the treatment of congested 41 the office of 3 176 INDEX. Mucus, cells concerned in the elaboration of 3, 13 the method of being discharged from goblet cells '14 Alullerian ducts, the development of the 2 N. Needles, those used in trachelorrhaphy 91 Nervous exhaustion 41 Neurasthenia 70, 99 Nitrate of Silver, application of, to the uterine cervix 83 ' the treatment of pruritus with . . 102 Normal salt solution 88 Nutrition, errors in, a cause of genital catarrh 22 O. Ointments, the method of applying 33 the use of, for genital eczema 33 for corrosive catarrh 40 Operation for pruritus 102 Ovaducts, physiological current of the 79 Ovaries, diseases of the, and catarrh 24 P. Pad, the vulvar 40 Parturition, the relation of, to muco-purulent catarrh 51 Pelvic organs, congestion of the, in constipation .... 42 Pelvis, condition of the, in sanguineous catarrh 99 Peritoneum, infection of the 79 Phosphate of Soda, the use of, for constipation . .42, 63 Portio vaginalis, the 8 the coverings of the 8 and genital catarrh 46 purulent catarrh 74 the secretions of the 8 Potassium permang. douche 35 Puberty, development of glands at 5, 10 INDEX. 177 Puerperium, the relation of, to purulent catarrh .... 74 Purulent catarrh ^2 the color of 76 in old women 'j^i Pruritus 81 an operation for 102 the treatment of 82, 102 in young girls 50 Pus cells, relation of, to the portio vaginalis 47 Pyogenic cocci, and acid media 15 and purulent catarrh 79 R. Reproductive life, the changes that belong to 45» 46 S. Salines, the use of, for constipation 42, 63 Sarcoma, diagnosis from sanguineous catarrh 97 Scarlet fever, a cause of genital catarrh 24, 29 Scrofulous diathesis 43 and catarrh in young girls .... 23 Sebaceous glands, the distribution of 7 Secretion, alkaline, of the uterus 8 Secretions, internal, generators of disease 20 Senile colpitis 95 endo-metritis and purulent catarrh "76 and sanguineous catarrh, 95, 98, loi Senility, the condition of the uterus in 96 Sexual excitement, the treatment of 43 hygiene 36, (i^ Sigmoid colon, the, and constipation 42 Skin, the condition of, in muco-purulent catarrh .... 57 Speculum, Cusco's 58 Ferguson's 83 Spray, method of using the vaginal 58 Staphylococci in the vulva 16 13 178 INDEX. Streptococci in the vulva 16 Students, neurasthenia in 44 Sutures, those used in trachelorrhaphy 92, 93 T. Tampon, the vaginal 59 medicated 61, 62, 86 method of making 84 Tannin, Glycerite of, douche Z7 Tenacious genital catarrh 39 Tension, surgical, necessity of avoiding, in trachelor- rhaphy 92 Thuja, the use of, for douching 82 Tissue remedies, the use of, in g3'nsecological diseases 6) Trachelorrhaphy 87, 89, 90 after treatment of 99 Tubercle bacilli in the vulva 16 Tuberculosis of the Fallopian tubes 78 a cause of purulent catarrh 79 U. Urethra, the lining of the 7 Uro-genital system, development of the 2 Uterine diseases and genital catarrh 24 glands, time of appearance of, in corpus .... 9 OS, erosion of, and muco-purulent catarrh . . 47 mucus plug in the 15, 49 secretion, alkaline, reaction of the n, 45 Uterus, catarrh of the 45 an erectile organ 67 displacements of the, in simple catarrh . . 36, 44 epithelial lining of corpus 9 involution of the, and muco-purulent catarrh 51 irrigation of the 87 lower segment of the, before puberty 2>^ mucous membrane of the 11 retroflexion of the 52, 97 INDEX. 179 Uterus, secretion of the, normally free from micro- organisms 16 subinvolution of the, and genital catarrh 36 Utricular glands in health and disease II V. Vagina, acid secretion of the 7, 14, 22 congestion of the, in muco-purulent catarrh 45, 46 catarrh of the 2J, 36 lining of the 7 mucous glands of the 7 a self-cleansing canal 53 Vaginal bacillus 15 mucosa in purulent catarrh 73 walls in senile purulent catarrh 72 Vaginitis, and muco-purulent catarrh 45, 46 simple catarrh 29 Virgins, erosion of the cervix in 52 laceration of the cervix in 52 Volsella, the authors for trachelorrhaphy 91 Vulva, in the catarrh of children 30 micro-organisms found in the 16 condition of the, in, muco-purulent catarrh... 47 Vulvitis and purulent catarrh y2> simple catarrh, the treatment of ...,40, 41 W. White sulphur springs, for the treatment of genital catarrh 100 Witch Hazel and Hydrastis douche 81 Y. Young girls, genital catarrh of 21 sanguineous catarrh of 98 Z. Zinc chloride douche loi stearate dusting powder 40 mm'ssfm^M^-si^wm-»M .^> UNIVERSITY OF CALIFORNIA LIBRARY Los Angeles This book is DUE on the last date stamped below.