aisa A 575186 ****** HERIA Heway to 190 Maste AN, M.D. A +5 "Pr outure The "gay Chyb BASE ở thuật tiến độ công qua là *45A * 2 if th wethe * J ** 30 942 Best of Ka Co wart Lon **** the ton of 20% IN CHE Sweet ره ما • eart may* ELLAM MORGAN, M HOME TOWED. IN A #majo بها وهي # SAY AMING (T ** LAM WARCHERY | pngton سب محرمه $40,000. • *330** ! Da đen trong my tranh cấp A IRISIITTIENT Jw w ARTES LIBRARY 1837 VERITAS UNIVERSITY OF MICHIGAN PLURIBUS UNUM SCIENTIA OF THE QUAERIS PENINSULAM AMOE NAM CIRCUMSPICE Guw FARJAWAHI KUKIOWAJUA HAQAAPTULAS EN FABRYER CHARACT BIRAK J " "" 1 " t J 14 i H616.93 M 85- !! 1 { J 1 1 [ 1 J DIPHTHERIA: 66963 Its History, Causes, Symptoms, Diagnosis, Pathology, and Treatment. Illustrated with numerous Cases successfully treated. BY WILLIAM MORGAN, M.D., Member of the Royal College of Surgeons, England; Member of the British Homœopathic Society; Physician to the Central Londen Homœopathic Institution; lare Physician to the Brighton Homœopathic Dispensary; formerly Physician to the North London Dispensary; Accoucheur to the West End Maternity Institute for Welsh Women ; one of the Medical Officers to the London Homœo- pathic Hospital, etc. MORS ÆQUO PULSAT REGUMQUE TURRES PAUPERUMQUE TABFRNAS. -Her. SECOND EDITION. LONDON: THE HOMEOPATHIC PUBLISHING COMPANY, 2, FINSBURY CIRCUS, E.C. BOERICKE & TAFEL, NEW YORK & PHILADELPHIA. And all Homeopathic Chemists and Booksellers. 1879. En Memoriam. FREDERICI FOSTER QUIN, M.D., THE PIONEER OF BRITISH HOMEOPATHY, WHO, DURING A LONG CAREER IN THE MEDICAL PROFESSION, ! WAS EMINENTLY SUCCESSFUL AS A PHYSICIAN ; WHO, IN THE INTERCOURSE OF PRIVATE LIFE, WAS A MAN OF THE MOST STARTLING WIT AND BRILLIANT ACCOMPLISHMENTS; WHOSE QUALITIES, BOTH PROFESSIONAL AND SOCIAL, RENDERED HIM A WELCOME VISITOR AND PROFESSIONAL ADVISER IN THE HIGHEST RANKS OF THE LAND; AND IN THE ROYAL CIRCLE A DEAR AND GUEST. THESE FEW LINES ARE OFFERED FAVOURED AS A SLIGHT TESTIMONY OF RESPECT TO ONE WHOSE LONG AND MERITORIOUS CAREER WAS MOST BENEFICIALLY AND UNSELFISHLY DEVOTED TO UPHOLDING THE DIGNITY, AND PROMOTING THE ADVANCEMENT OF HOMEOPATHY, BY THE AUTHOR. PREFACE. SECOND EDITION. THE first edition of this monograph was presented to the reader in the form of a pamphlet, being simply an extract from a paper which was read at a meeting of the British Homœopathic Society in the year 1860, and has since been out of print for some time. The terrible and lamentable calamity which has so recently thrown a gloom and a curtain of mourning over this land, by the sudden and untimely death of a beloved Princess by the mysterious and subtle poison, unfortunately too well known under the name of Diphtheria, has induced the Author to prepare for the public and profession a more com- plete résumé of this little work. The greater portion of the pamphlet has been rewritten, and a considerable amount of historical and practical matter has been blended, and the whole carefully revised, which, the Author hopes, may 6 Preface. 1 throw some new light on the history, symptoms, pathology, and treatment of so mysterious and fatal an invader. It may, however, be observed that the section devoted to the selection of reme- dies and topical applications has been retained in its entirety. It is the one the Author chalked out for guidance. when he first encountered Diphtheria in 1858. It is the one which has acted as his daily guide to the present time, has but seldom failed him, and which has enabled him to perform brilliant and startling cures, and reduce the mortality to a mere fraction. Since 1858 the author has treated over fifty cases of Diphtheria, some of a mild. form, others of a most malignant type, three only having succumbed to the fatal influence of this dangerous malady a form of disease which has hitherto baffled or eluded the skill and ability of the ablest physicians of our day, and has formed a subject of critical disquisition Preface. 7 in the allopathic ranks. This same disease also continues a momentous and crucial test of the ability of those pro- fessors of the healing art, who frankly and unreservedly confess that the death- roll under their mode of treatment far ex- ceeds that of Asiatic cholera in its most malignant form-viz., 75 to 82 per cent. "The following figures relative to the deaths from Diphtheria, gathered from the annual reports of the Registrar- General, may be of some interest just now. It is only since 1855 (the year of the severe epidemic of Diphtheria in France) that this disease has been placed under a separate heading in the tables of mortality. It appears that from 1855 until the end of 1876, 81,361 deaths. from Diphtheria were registered in England, or 0.78 per cent. of the total number of deaths from all causes. Excluding from consideration the first three years of this period, in which some of the deaths appear to have been 8 co Preface. recorded under other headings, it seems that the greatest number of deaths occurred in the year 1859, when as many as 10,184 were registered, being 2:3 per cent. of the total number of deaths in that year. The lowest rate was in 1872, when only 2,152 deaths occurred, or 0'43 per cent. of the whole number recorded. During the ten years 1861-70, 18,467 males and 20,987 females died from Diphtheria, or a total of 39,454, of which no fewer than 22,150, or 56'1 per cent., were children under the age of five years, and 9,925, or 25.1 per cent., were between five and ten years old. Thus 81 per cent. of the deaths during that period occurred among children under ten years of age. Between the ages of ten and fifteen 3,082 were registered, or 78 per cent., leaving just II per cent., including those of fifteen years and upwards. The disease seems to be most fatal to chil- dren between one and two years of age, as over 13 per cent. of the total number Preface. of deaths during 1861-70 occurred at that period. In the year 1876 the deaths from Diphtheria were relatively more fatal to children than in the period 1861-70; the total number being 3,151, of which 90'1 per cent. were those of children under ten years of age, and 27 per cent. those between the ages of ten and fifteen years. In the list of 115 causes of death in England in 1876, Diphtheria comes 29th in the order of fatality. The tables of mortality published by Dr. Farr in 1875 disclose the curious fact that more persons die of Diphtheria in the healthy districts of England than in those where the general mortality is higher. For instance, in the healthy districts, out of 100,000 persons born 1,029 die of Diph- theria; while in the less healthy districts, such as Liverpool, the deaths from Diph- theria amount to only 441. On the other hand, the deaths from scarlet fever in the healthy districts number 2,140, while in Liverpool they are 3,830 out of IO Preface. every 100,000 born. Again, the popula- tion of the south-eastern counties is about two-thirds that of London, and yet the deaths from Diphtheria in those counties exceeded by 37 the deaths from that disease in the Metropolis. The best medical authorities assert that the disease has existed from the earliest days of medical history; but it certainly did not occupy a very distinct place in no- sology until a comparatively recent date. The severe epidemic at Tours in 1818 led to a thorough investigation of the disease by Bretonneau, who gave it the name of Diphtherite. There can be no doubt, however, that there is still much to be learned as to the cause of this disease." Having these imposing and formidable statistics in view, I appeal to the whole. profession to throw aside the cloak of dogmatism, and give my mode of treat- ment a fair and unbiased trial. 23, WELBECK STREET, CAVENDISH SQUARE, W. February 14th, 1879. . PREFACE. FIRST EDITION. THE views propounded in the follow- ing pages on the symptoms, causes, pathology, and treatment of that terrible disease, "Diphtheria," were submitted to the consideration of the members of the British Homœopathic Society, at a meeting held on 4th October, 1860, under the presidentship of Dr. Frede- rick Foster Quin. Subsequently to this, the Author was pleased to learn that one of its most distinguished members, "Dr. Madden, of Brighton," had applied the mode of treatment suggested by him; and in a letter to the Honorary Secretary of that Society writes thus:- "December 6, 1860.-Since the meeting at which I expressed the above opinion, I have treated several } 1 I 2 Preface. cases of severe Diphtheria in the way recommended by Dr. Morgan, and with COMPLETE SUCCESS. In both cases, I think the alternation of Belladonna with the Mercurius Biniodatus was advantageous; and in one (the worse of the two) the throat was not pro- gressing rapidly under the topical use of permuriate of iron, and I used the Hydrochloric Acid with DECIDed BENEFIT." An Appendix has been added to the original paper, containing a list of medi- cines and their potencies, with brief directions as to the mode of applying the topical remedies. CONTENTS. Preface In Memoriam Introduction-Death of Princess Alice Earl Beaconsfield's Speech of Condolence to the Queen. His Royal Highness the Prince of Wales's Pa thetic Reference to the Princess Alice Diphtheria the most terrible of all disorders Hahnemann's Theory of Homœopathy illustrated in Cholera Practical Test of the Law in all parts of the World : • History of Diphtheria-Authorities: Hippocrates, Aretous, Villa Real, De Fontecha, Cartesius, Alaymus, Fothergill, Bard, Bretonneau, etc. Diphtheria in Rome, A.D. 580 . • • Sup. osed Causes of Diphtheria similar to Asiatic Cholera, Yellow Fever, Plague, Typhus, Typhoid, Ague, etc. Diphtheria appeared in Boulogne, 1855 Deal, Walmer, Canterbury, Ash, Dover, 1858 Author's Views as to Nature of Diphtheria PAGE 5 3 17 • 18 21 22 23 23 26 27 28 28 30 14 Contents. PAGE Definition of Diphtheria-Derivation of 33 Symptoms of Diphtheria-Constitutional Stages 34 Diphtheritic Membrane, Character of: Appear- ance of Mouth, Fauces, Tonsils, Uvula, and Glands f Neck 1 Sequelae of Diphtheria, Paralysis, Anæmia, Loss of Voice, Deafness, Squinting, Fotid Dis- charge from Nose, Rheumatism, Purpura, Prostration of Strength, etc. → Diagnosis of Diphtheria: Sir William Jenner's Views and Abortive Treatment • • 35 39 Homœopathic Law a Guide to the Selection of Preventive and Curative Agents. Illustrations. Comparative Table of Mortality under Allo- pathic and Homoeopathic Treatment of Diph- theria and other Diseases: Yellow Fever, Small-pox, Scarlet Fever, Asiatic Cholera, Dysentery, Typhus, Typhoid, Ordinary Fevers, Pleurisy; Inflammation of Lungs, Peritoneum, and Brain; Apoplexy, etc. All diseases, average of 42, 43, 44, 45 Statistics from Report of St. George's Hospital, 1864 • 39 46 Diphtheria supposed to be analagous to Dysen- tery, Scarlet Fever, Croup, and Typhoid, in mode of killing 48 True Diagnosis in Detection of False Membrane with Eye on Pharynx, Tonsils, Uvula, etc. 49 History of Case, General Appearance of Patient, whether similar disease in same locality 49, 50 Contents. 15 · • Diphther a same as Croup; Author's Views; French Physicians' ditto Diphtheritic Eruption on Skin Distinguishing Characteristics between Diph- theria and Scarlatina Maligna, Thrush, and Croup 53, 54, 55, 56, 57 Membrane formed by a Blister similar to Diph- theria 58, 59 • Selec ion of Internal Remedies in accordance with the Law of Similars: viz., Acon., Bell., Merc. -Sol., Mec-Biniod., Ars., Bichrom., Pot., Spong., Iod., Lach., Hep.-S., Cinch. Seneg., Canth. their Pathogenesis Cantharis-its Effects on Dogs . Treatment--Preventive, Hygienic, and Hydro- pathic Preventives of other Diseases 58, 59 The adoption of Specifics and Topical Applica- tions to Mouth -Spray, Gargle, etc.; Avoidance of Unhealthy Localities; removal of all Sewer- age Stagnant Pools, and Ditches; avoidance of North-East Winds; Hygienic Treatment of Children, Baths, Clothing, etc. Certain Hereditary Signs of Croupal Diathesis. First Signs of Diptheritic Deposit: Rules to be observed, and use of Topical Remedies- Gargling, Painting, Mopping, Spray, and Inhalation. 61, 62, 63 Allopathic Treatment useless-Mortality over 70 64 per cent. • PAGE • 51 52 60 60 65 77 16 Contents. Local Applications recommended by different authors Chemical Experiments on False Membrane Hydropathic Appliances: Turkish, Hot Air, and Warm Baths, Wet Sheet, Compresses, etc. Hygienic Treatment: Condition of Room, Venti lation, Temperature, Disinfectants, Diet, etc., in different stages of the disease 86 Cases Illustrative of Successful Treatment 88 to 123 Appendix: List of Medicines for Pharyngeal Diphtheria-Do. Laryngeal Diphtheria 126, 127 Mode of Applying Hydrochloric Acid, Com- presses, etc. • • PAGE 77, 78 • 79 D - Chapter on Disinfectants-their respective effi- cacy, etc. 131 to 144 83 127 DE Diphtheria. INTRODUCTION. THAT irreparable national calamity, the sudden and untimely death of Her Royal Highness Princess Alice, Grand Duchess of Hesse-Darmstadt, is my plea for sending forth a second edition of my practical experience of the terri- ble disease which has robbed us of that amiable and beloved Princess, whose noble qualities are as "household words," and whose passing away from B 18 Diphtheria. among us at so early a period of a happy and bright career, has cast a deep gloom over this and other lands. Long will endure the memory of the sweet, wo- manly virtues and graces that adorned her self-sacrificing and beautiful charac- ter. She is gone and has met the death of a martyr. The Earl of Beacons- field has well and pathetically told us that, "A Princess who loved us, though she left us, and who always revisited her fatherland with delight-one of those women the brightness of whose being adorned society and inspired the circle in which she lived-has been removed from this world, to the anguish of her family, her friends, and her subjects. Princess Alice-for I will venture to call her by that name, though she wore a crown-afforded one of the most striking contrasts that I can remember of richness of culture and rare intelligence combined with the most pure and refined domestic Diphtheria. 19. sentiments. You, my lords, who know her life well, can recall those agonising hours when she attended the dying-bed of her illustrious father, who had sketched out her studies and formed her tastes. You can recall, too, the moment at which she attended her royal brother at a time when the hopes of England seemed to depend on his life; and now you can remember too well how, when the whole of her own family were stricken by a malignant disease, she had been to them the angel of the house till at last her own vital power was perhaps exhausted, and she has fallen. My lords, there is something wonderfully piteous in the immediate cause of her death. The physicians who permitted her to watch over her suffering family enjoined her. under no circumstances whatever to be tempted into an embrace. Her admir- able self-restraint guarded her through the crisis of this terrible complaint in 1 20 Diphtheria. safety. She remembered and observed the injunctions of her physicians. But it became her lot to break to her son, quite a youth, the death of his youngest sister, to whom he was devotedly attached. The boy was so overcome with misery that the agitated mother clasped him in her arms, and thus she received the KISS OF DEATH. My lords, I hardly know an incident more pathetic. It is one by which poets might be in- spired, and in which the professors of the fine arts, from the highest to the lowest branches, whether in painting, sculpture, or gems, might find a fitting subject of commemoration. My lords, it is impossible to depict at this moment the sufferings of the husband whom she has left behind and of the children who were so devoted to her ; but our duty is to offer our condolence to one whose happi- ness and whose sorrows always excite and command the loyalty and affectionate # Diphtheria. 21 respect of this House, Upon Her Majesty a great grief has fallen which none but her Majesty, none but the Queen, can so completely and acutely feel. Seventeen years ago her Majesty experienced the crushing sorrow of her life, and then she was particularly sus- tained by the daughter whom she has now lost, who assisted her by her labours, and aided her by her presence and counsel. Her Majesty now feels that the cup of sorrow was not then exhausted. I feel it impossible to use any language which could express the consolation we wish to extend to her in her sorrow. Her suffering is too fresh to allow of solace; but, however exalted her position, I feel that she will be sus- tained by the consciousness that she possesses the sympathy of the nation.” Finally, to quote the language of her illustrious brother, the Princess was "so good, so kind, so clever. We had gone с 22 Diphtheria. through so much together-my father's illness, then my own; and she has succumbed to the pernicious malady which laid low her husband and children, whom she nursed and watched with unceasing care and attention." Among the various epidemic and contagious diseases which afflict huma- nity, there are few that have created more alarm and anxiety in the public mind, or claimed a larger percentage of victims, than the fatal malady we are about to investigate, which has just turned a nation into a house of mourning. Diphtheria is of all disorders at once the most terrible, and the one least known by the majority of the medical profession. The laws which regulate the incidents and course of typhoid fever, cholera, scarlet fever, and most other epidemic diseases, are to a certain extent well understood; but diphtheria remains, as in old times did the plague, Diphtheria. 23 beyond the range of the medical science as practised by a large section of the profession; it is, however, as amenable. to treatment under the homœopathic system as the most trivial complaint. When Hahnemann heard of the first approach of cholera to Europe, he gave it as his opinion that if there were any truth in the homoeopathic law, Camphor, Cuprum, and Veratrum were its specifics. A practical test of these remedies in all parts of the world by thousands of physicians, have proved the wisdom of such a selection. When diphtheria was first encountered by me in 1858, I adopted the same principle, and the result having been uniformly successful, I feel I can with the utmost confidence recommend a similar course to the pro- fession and public at large. HISTORY OF DIPHTHERIA. Before, however, I proceed to describe the symptoms, pathology, and treatment 24 Diphtheria. of diphtheria, it were well to take a slight glance at its history and ante- cedents. Historically, diphtheria is no new disease, but stands coeval with the records of medicine as handed down to us from the era of Hippocrates, centuries anterior to the Christian era. Aretous, an eminent physician of Cappadocia, A.D. 200, gives a graphic description of this disease under the name of "Egyptian or Syrian ulcer." In 1590-91 it assumed an epidemic form in various parts of Spain, as clearly described by Villa Real, De Fontecha, and Herrera, who called it morbus suf- focans, and by others Garrotillo. In 1618 it invaded Naples, where it was called epidemicus strangulatorius, the popular name being male-de-canna. In 1625 it broke out in Sicily, as described by Cartesius, who called it Gulæ morbus. Diphtheria. 25 In 1632 it was very prevalent in Syria and Colo-Syria, as described by Alay- mus, and called by him the Syrian ulcer. In 1747 it broke out in various parts of Italy. In 1739 we find it invading England, as described by Dr. John Fothergill, in a work entitled, "An Account of the Putrid Sore Throat," who also called it morbus strangulatorius. From 1755 to 1762 it ravaged various parts of Sweden, and in 1789 it first appeared in America, as described by Dr. Bard, of New York, and others. From 1821 to 1826 it appeared in dif- ferent parts of France, as described in two admirable memoirs by M. Bre- onneau, of Tours, who called it diph- therite. In 1855, after an absence of some seventy years, it reappeared in England, and from that date to the present time. has committed sad ravages in the towns, 26 Diphtheria. villages, hamlets, and secluded cottages in various parts of the country. As far back as A.D. 380 a similar epidemic broke out in Rome, with such virulence, and to such an extent, that propitiatory offerings were made to the gods. It is therefore very clear from these historical records that diphtheria is no new disease, but, like other epidemic. disorders, it appears, dies away, and reappears at certain intervals. SUPPOSED CAUSES. As the principal object of this little treatise is to convey to the reader a practical knowledge of the leading symptoms, pathology, and treatment of diphtheria, I shall not indulge in vague or speculative theories as to its pro- bable cause and origin, beyond briefly Diphtheria. 27 alluding to the fact, recognised more or less by the profession at large, that as every epidemic has its congenial clime, and circumstances favourable to its pro- duction-the Asiatic cholera, for in- stance, springing from the delta of the Ganges, the yellow fever from the swampy banks of the Mississippi, or lagoons of Africa; the plague hovering around the Nile in Lower Egypt, the banks of the Tigris and Euphrates; the ague emerging from fens and marshes, the typhus and typhoid fevers arising from the ill-ventilated, badly-drained courts and alleys of our towns-so the development of diphtheria may perhaps be attributable to the products of de- composed animal and vegetable matter in our sewers, and to the direct poi- sonous influence of these noxious par- ticles upon the mouth and its surround- ing structures. It may be in the recol- lection of many that prior to 1855 28 Diphtheria. rumours reached England that an epi- demic of a very fatal character, and sup- posed at the time to be closely allied to the malignant form of scarlet fever, was committing great havoc at Boulogne- sur-Mer; indeed, for some time the disease was only known as the "Bou- logne Sore Throat." In the early part of 1858 a similar epidemic broke out almost simultaneously at several towns. on the coast of Kent, such as Deal, Sandwich, and and that pretty village Walmer, a spot of well-known salu- brity, and rendered memorable to every Englishman as the favourite resort of the greatest captain of his age, and the closing scene of that immortal hero's life. From thence it would appear to have taken an inland course by visiting Canterbury and its surrounding villages and hamlets, being particularly fatal at a little place called Ash, a rural, well- cultivated, and healthy district, situate A Diphtheria. 29 on a gentle slope about midway be- tween Canterbury and the ocean; and such was the disastrous effect of the disease on that locality, that for a con- siderable time it was only known to the inhabitants of that part of the country as the "Ash Sore Throat." In August and September of the same year there were certain indications afloat that some such unwelcome and fatal visitor had reached Dover. The sombre under- takers were seen plying their sad avoca- tion more frequently than usual, and doctors might be seen at the corners of the streets in close and friendly con- verse—a rare sight on other occasions. Deaths from diphtheria were registered in the weekly papers, and it soon be- came generally known that the disease had in reality scaled the ramparts of that impregnable fortress, and invaded the town. The disease was particularly fatal at 30 Diphtheria. Dover; some scores of children and many of mature age were swept away by it. The series of cases which came under my immediate notice were twenty- five in number, the majority being of a mild form, but several showed evident symptoms of a decidedly malignant type. This was my first introduction to diphtheria, and from the experience I then derived I came to the conclusion, which a further intimacy with the dis- ease has not in any way altered, that- Istly. Diphtheria is allied to the family of epidemic diseases, and is more or less contagious in its nature. 2ndly. That diphtheria is a peculiar blood-poison, attacking principally, and having a special affinity for, mucous membranes, more prominently that of the mouth and fauces. 3rdly. That diphtheria is closely allied to croup, not only in its stage of incuba- Diphtheria. 31 tion, maturity, and decline, but in the nature, appearance, and structure of the morbid product (false membrane), as well as in its mode of killing. 4thly. That diphtheria has a tendency to spread and attack other parts of the body covered with mucous membrane, namely, the lips, nose, and the glands of the neck (doubtless by extending along the ducts); it will also descend into the pharynx, windpipe, and bronchial tubes, developing there a species of croup, and causing death by suffocation; in fact, I am disposed to look upon diphtheria as croup of the mouth, and croup proper as diphtheria of the larynx. 5thly. That diphtheria, like other epi- demic and contagious diseases, may appear in a mild as well as a malignant form, the one running a smooth and un- chequered course to convalescence, and leaving no signs behind in the form of sequelæ, the other intractable from its 32 Diphtheria. very commencement, and developing a raging fever, delirium, enormous enlarge- ment of the glands of the neck, present- ing a strong resemblance to one of the worst forms of scarlet fever, with pro- fuse salivation, a filthy sanious discharge from the nostrils, and the development of large and thick patches of a tough elastic membrane, resembling soddened parchment or washleather, from whence emanates the most fætid odour; leaving behind as sequelæ a painful train of in- tractable disorders of the nervous and general system. 6thly. That diphtheria, in addition to its special peculiarity of forming false membranes, gives rise to a stench of a very offensive nature-one sui generis- which having once been encountered cannot easily be forgotten. This I deem an important feature of true diphtheria and pathognomonic of the disease. Diphtheria. 33 DEFINITION OF DIPHTHERIA. Diphtheria may be described as an epidemic and contagious sore throat of great severity, running a rapid and definite course, and due to some mysterious specific blood-poison, which has a marked affinity for the mucous membrane of the pharynx, larynx, tonsils, and uvula, on the surface of which it deposits a plastic exudation of lymph, forming by degrees a false membrane of more or less thickness and tenacity, like some unwholesome fungus, which sends forth an intolerable stench. When an attack of the disease is fol- jowed by recovery it often leaves behind an altered condition of the voice, partial paralysis of the muscles of deglutition, weakness of the limbs, impairment of vision, and other secondary nerve dis- orders. Children are more liable to the invasion of this specific blood-poison than adults. It is most common amongst 34 Diphtheria. the poor, or such as reside in damp situa- tions and badly drained houses. It does not, however, spare the rich, the lordly or the Royal houses, as witnessed by the lamented death of our beloved Princess Alice. The term diphtheria is derived from the Greek, Aɩpfēpa, a skin or mem- brane, and has as synonyms angina maligna, cynanche membranacea, putrid sore throat, and malignant quinsy. SYMPTOMS OF DIPHTHERIA. Diphtheria, like other acute specific contagious diseases, has its stage of incubation, stage of maturity, and its stage of decline, and often leaves, par- ticularly in its malignant form, painful and obstinate sequelæ. The premoni- tory symptoms are marked in some by a gradual feeling of depression, uneasi- ness, chilliness, some muscular debility, headache, nausea, and drowsiness, with at times a slight diarrhoea, and a pulse somewhat quickened, with a slight in- Diphtheria. 35 flammatory condition of the tonsils and arches of the palate, followed, in the course of two or three days, by the ex- udation of lymph, forming a false mem- brane, which may adhere only to a por- tion of the uvula, or to one of the parotid glands. In other cases it is marked by high fever, a quick pulse, a flushed face, a hot dry skin, and anxious staring look, with a rapid swelling and tenderness of the glands situate about the angles of the lower jaw, which more or less impede its normal action. These symptoms may continue with some severity for two or three days, when, on opening the mouth, there will be perceived a certain redness and swelling of the parts in- vaded by the poison; sometimes the tonsils, sometimes the arches of the palate, sometimes the posterior surface of the soft palate, at other times the nostrils or the mucous membrane of 36 Diphtheria. the pharynx may be selected as the starting-point for the local manifestation of this terrible poison. On the surface of the selected spot is first seen a kind of half-transparent coagulated mucus, which after a little while becomes changed into a tough, elastic substance, which has been aptly compared to soaked parchment or washleather. This is the true" diphtheritic membrane." Thus starting from one or more centres, the membrane spreads anteriorly to the soft palate, upwards to the posterior openings of the nose, and downwards to the epi- glottis, the windpipe, trachea, and bron- chial tubes; at other times it may de- scend into the gullet, and from thence into the stomach and intestines. If this foul, fungous-looking growth is mechanically removed, it exposes to view an angry raw bleeding surface. (which bears a strong resemblance to those irritable bleeding ulcers which arise. Diphtheria. 37 from other specific causes), upon which the putrid miasma almost immediately gathers itself together with renewed strength. When a part is severely or deeply in- flamed, the lymphatic glands surround- ing the neck, and to which the lym- phatics of the inflamed part lead, become the seat of active congestion, and ulti- mately of inflammatory exudation, marked in many cases by an enormous enlargement of the whole neck, bulging out beyond the margin of the lower jaw. In this disease we have an illustration of this general law; for the lymphatic glands, to which the lymphatics of the pharynx and surrounding parts lead, are found to be much larger, redder, and moister than in their normal condition. When the membrane begins to sepa- rate and decompose, there follows a horrible fœtid breath, and when thrown off there may be left ulceration, slough- D 38 Diphtheria. ing, or gangrene, or the tissues may gradually assume a healthy appearance. The constitutional symptoms of diph- theria vary according to the virulence of the poison, and the constitution affected. In some the symptoms are slight, in others there is rapid prostration of strength, great restlessness, delirium, and high fever; the pulse increases rapidly, the saliva dribbles from the mouth, and the breath is highly fœtid. There is no desire for food or the slight- est exertion, there is bleeding from the nose, mouth, or bronchial tubes, and a highly albuminous condition of the urine. Death may take place from ex- haustion, from hæmorrhage, uræmic poisoning, gangrene, or suffocation, consciousness, as a rule, remaining to the close of the scene. Even should the natural strength and vigour of the patient ultimately prove superior to the poison, the danger is Diphtheria. 39 not yet passed. Of all epidemic poisons diphtheria is the one the subsequent effects of which are most to be dreaded. The patient who has escaped with his life is rendered liable to disorders of a painful and distressing nature, not the least frequent of which is a form of general or partial paralysis. Some are affected with paralysis of one half of the body, others of the lower half of --- the body, others again with general anæmia, loss of voice, deafness, squint- ing, a fœtid discharge from the nose and ear, rheumatism, purpura, and a peculiar prostration of strength which may con- tinue for many months in spite of the most tender care and nourishing diet. ….. DIAGNOSIS. A correct diagnosis, in other words. a correct knowledge, of any disease, 40 Diphtheria. ¡ will lead us to a correct and successful treatment of the same; for it has long since been maintained that a thorough knowledge of the disease is half its cure. Strike at the root of a tree, the leaves fall and the branches wither. Diphtheria is no exception to this rule, and it is with pain I record some observations made by Sir W. Jenner in clinical lec- tures delivered by him some years ago on the symptoms and treatment of diphtheria, that there existed no specific remedy to counteract that complaint, but that it must be treated on the same general principles as other acute specific diseases. "We have," says Sir William, "no specific remedy for any of the acute specific diseases; we save by medical aid many lives that would be lost from scarlet fever, typhoid fever, typhus fever, measles, etc.; we save such lives, however, only by from time to time averting certain modes of Diphtheria. 41 death. The specific disease is not cut short, it is not cured by our remedies; it runs its course, do what we may to prevent it. To avert death in any given acute specific disease, we must know how it kills. Scarlet fever, for instance, firstly by the severity of the general affection; secondly, it kills by the local throat disease and its consequences; thirdly, it kills by producing an ab- normal condition of the kidneys; fourthly, it kills by extending its ravages to the heart and lungs." If Sir W. Jenner would condescend to investigate the leading principles of Homœopathy, he would find that there exists in nature a specific remedy for every specific disease. The records of that system of medicine have already brought to light the startling fact that remedies not only act as preventives or prophylactics, but also as specifics, if carefully and judiciously selected in 42 Diphtheria. accordance with its leading principles, namely, Similia similibus curantur,which simply signifies, "To cure a disease, select a remedy which, in accordance with its pathogenetic effects on the body in health, is capable of producing a like disease. To illustrate this, the Atropa Belladonna has been found to protect the system against the invasion of scar- let fever; Pulsatilla against measles; Quinine, Cedron, or Arsenic against inter- mittent fever; Camphor, Copper, and the White Hellebore against Asiatic cho- lera; the Eucalyptus Globulus against yellow fever; Mercurius Vivus against syphilis; and vaccination against small- pox. These illustrations might be inde- finitely extended did space permit, but the above will suffice for our present purpose. As a further illustration of Sir W. Jenner's sceptical views on the efficacy of drugs as prophylactic or curative agents, he calmly tells his Diphtheria. 43 hearers that out of fifty-eight cases of diphtheria which came under his imme- diate notice, thirty-four proved fatal, leaving to the King of Terrors an enor- mous legacy of deaths, amounting to over seventy-five per cent. By way of further repudiating the views propounded by Sir W. Jenner as to the non-specific action of certain drugs over certain specific diseases, I append here a tabular statement of the leading diseases as treated under both systems of medicine. COMPARATIVE TABLE OF MORTALITY. Diphtheria. Allopathy Homœopathy. • 70 per cent. 15 Febris flava-Yellow Fever. Allopathy. Homœopathy. Variola-Small-pox. Allopathy Homœopathy. "} 65 per cent. 3 "} 24 per cent. 8 >> 44 Diphtheria. Febris rubra-Scarlet Fever. Allopathy. Homœopathy. • Cholera Pestifera-Malignant Cholera. Allopathy Homœopathy. Allopathy Homœopathy. Dysenteria-Dysentery. Allopathy Homœopathy. • 20 per cent. 3 Typhus-Typhus Fever. 16 Allopathy Homœopathy. 50 per cent. 20 Allopathy.. Homœopathy. در 22 per cent. 3 " 14 Ordinary Fevers. در per Febris Enterica-Enteric, or Typhoid Fever. cent. در 20 per cent. 10 ** 9 per cent. 2 در Diphtheria. 45 Pleuritis-Pleurisy. Allopathy Homœopathy. Allopathy Homœopathy. Peritonitis-Inflammation of the Peritoneum. · Allopathy Homœopathy. Inflammatio cerebri-Inflammation of the Brain. Allopathy Homœopathy. • Allopathy Homœopathy. 13 per cent. 3 Allopathy Homœopathy. "? Apoplexia-Apoplexy. • Pneumonia-Inflammation of the Lungs. 23 per cent. 5, 40 per cent. 4 All diseases on the average. رر 70 per cent. 6 "" 87 per cent. 29 " 16 per cent. 3 ر, 46 Diphtheria. Extract from the Report of St. George's Hospital for 1864, showing the COMPARATIVE DEATH RATES For I and 7 Years. DISEASE. Continued fever... S arlet fever Erysipelas Acute Rheumatism Anasarca... Ascites Epistaxis... Hæmoptysis Hæmaturia Hæmatocele Intestinal ... ···· ... ... ... ... ** ... ... Uterine Purpura Cachemia Scrofula Phthisis Tabes Intestinalis ✰✰✰ ··· ... ... ... ... ... *** • Epithelioma Tumors of bone Delirium Tremens Tetanus Cephalitis Epilepsy... Apoplexy ... ··· ... .. Tubercles in Brain Accretions in Peritoneum Hydatids... Encephaloma Scirrhus Colloid ❤ ……… ... ... .. ... ··· • ... ·· ··· •*• :. : : ** ... ... : Per cent. 14'53 23.07 20'0 5'55 28.2 14'3 14.8 16.4 33'3 44'4 39'6 50'0 100 0 100'0 65'4 28.5 1 40'0 100 0 27.2 64.2 Per cent. for 7 Years. 11'5 13'04 14'7 4'39 35°2 46.3 13'7 21'I 8:00 9'09 19'1 5.35 23.6 43'I 20'7 34'3 50'0 95'0 89.6 53.8 73'3 19'4 50'0 66.6 100 0 22'I 16.6 89'9 16.2 61.1 Diphtheria. 47 DISEASE. Coma and Convulsions ... Inflammation of Spinal Cord Hemiplegia Paraplegia Pericarditis Endocarditis Hypertrophy Dilatation Valvular disease A eurism Phlebitis... Laryngitis Trachitis Bronchitis Emphysema Pneumonia Pleurisy Pertussis... Pneum -thorax ... ... ··· ... ... *** *** ·· ... ... ·· ··· ** 4. : : ... • ... Peritonitis (Acute) ... Cirrhosis ... Jaundice Nephritis Absce-s Albuminuria Diabetes... Dropsy of ovaries (Chronic) ••• ... *** ... ... ... : ... *** ... Ulceration of Tonsils Ulceration of Stomach Obstruction of Intestines Diarrhoea Dysentery Ulceration of Intestines... : *** T ... ··· ... 4. ... : ... ··· ... ... ... • • 1 ✰✰ Per cent. 57'1 100 0 18.7 14.2 31.8 12'5 72.7 57.I 26.5 50% 50'0 25'0 75°0 17'5 30'0 38.8 33'3 JOO'O 18.1 42.8 1000 8.82 33.3 100*0 34.7 35.7 100 0 8·00 23.07 50'0 41.6 14'2 27'2 Per cent. for 7 Years. 53°3 70.50 9 40 13.7 34°2 9 70 62.1 52.7 25.8 50'0 31'7 42.8 45'4 13.08 34.8 314 32.8 3·00 75'0 II.4 75.0 55'0 8.29 36.1 100 0 40 0 41'5 77'I 21'4 21'5 38.4 44'9 12.8 24'4 48 Diphtheria. ¡ ! Diphtheria is considered by some phy- sicians to be analogous to dysentery, by others to the malignant form of scarlet fever; others, again, to the croup of childhood. An eminent writer considers that it bears a closer affinity to typhoid fever than to any other acute specific disease, particularly in its mode of killing, for in typhoid fever the patient may die quickly of the general affection, namely the fever; or, the symptoms of the general disease being trifling, the sufferer may die of a local consequence of such fever, to wit, perforation of the bowels. Diphtheria kills in a similar manner, and the patient may die quickly of blood-poisoning or the false membrane may escape from the mouth into the windpipe, and cause death by suffocation, many days after its first appearance on the pharynx. That there are great affinities between diphtheria and these diseases is tolerably clear, but it is at the same Diphtheria. 49 time difficult to establish the identity of their ultimate essence. Scarlet fever, typhus and typhoid fever, small-pox, measles, and chicken-pox, have their own special symptoms and outward manifestations as indicative of a special exciting cause; the premonitory symp- toms may be similar, but their outward manifestations are very dissimilar; so also is diphtheria. The absolute diagnosis of diphtheria, in any given case, must rest on the de- tection by the eye of the false mem- brane in its various stages of develop- ment on the mucous membrane of the pharynx; but the experienced observer may often suspect that the disease is diphtheria, even before the slightest indication of the exudative process takes. place, just as in small-pox, scarlet fever, or any other specific eruptive disease. When diphtheria, for instance, assumes an epidemic form, has recently 50 Diphtheria. occurred in the same house, or is known to prevail in the neighbourhood, and the mucous membrane of the pharynx is found red and swollen, the uvula thickened, and the parts bedewed with a thickish mucus, coupled with a certain amount of pain and enlargement of the glands behind the angles of the jaw, with bleeding, or a sero-purulent dis- charge from the nose, there will be strong presumptive evidence that the disease is diphtheria. The general appearance of the patient will likewise add weight to these local nianifestations, as in many cases which I have seen there is a peculiar dusky or leaden hue of the skin, with a pallid, pasty aspect of the countenance. Diphtheria is not the only disease capable of throwing out. a false membrane, as we find a similar production occupying the same part of the mouth in certain forms of scarlet fever, in the thrush of childhood and Diphtheria. 51 advanced age, and more particularly in the croup of childhood, which bears an almost identical resemblance in its structure to that of the anatomical fea- tures of the disease under consideration. Indeed, as far as my knowledge ex- tends I am disposed to look upon diph- theria as croup of the mouth, and croup proper as diphtheria of the windpipes, This I am pleased to learn is fully endorsed by the investigations of some. of the leading physicians in France, to whose deep researches and practical ex- perience we are so much indebted for valuable information on this very painful subject. Some have endeavoured to link a close relationship between scarlet fever and diphtheria, and that it is only another type of the same disease, modi- fied more or less by certain telluric and climacteric changes. In support of such a theory, it is somewhat remarkable that diphtheria and scarlatina maligna 52 Diphtheria. have frequently been observed in close alliance at one and the same time, and in the same locality. In 1854-5, whilst the disease raged with great virulence at Boulogne-sur-Mer, I was able to ascertain that these peculiar types were invading the town at the same time, the scarlet fever skirmishing along the upper part and suburbs, whilst diphtheria was hugging closely the lower part of the town and harbour, decimating hundreds of its young population. It is also worthy of remark that diphtheria is represented by a certain rash on the skin. This I have noticed on several occasions. It is of a dusky leaden hue, which comes and. goes quickly. I have also seen the sudden disappearance of the eruption followed by a rapid swelling of the glands surrounding the neck, and the no less rapid appearance of the membrane on the fauces and parotid glands. In the following tables I shall en- Diphtheria. 53 deavour to compare in detail the pecu- liar characteristics which distingush the anatomical features of the false mem- brane of diphtheria from that of scarlet fever, thrush, and croup. In Starlet Fever. 1. The rash on the body, and the peculiar straw- berry-like tongue, forms its main fea- tures, and are but seldom absent. 3. The mem- brane in the throat is similar to that of thrush, a soft pappy deposit, easily de- tached, and has no tendency to spread. 2. The pulse runs higher than in any other epidemic quent. fever. - In Diphtheria. 1. The rash is only present in ex- ceptional cases, 2. It is only moderately fre- mem- 3. The brane adheres closely to the epi- dermis, and has a tendency to spread to the air passages, the nose, stomach, anus, and vagina. E < 54 Diphtheria. In Scarlet Fever. 4. Abscess of the glands of the neck is common. 5. Dropsy is a common sequel. 6. Affections of the joints are com- mon after scarlet fever. 7. Pericarditis common. 8. Paralysis oc- curs very seldom. In Diphtheria. 4. Abscess very rare, not having met with with one in nearly a hundred cases. 5. Dropsy is but very seldom met with. 6. They are scarcely ever met with after diph- theria. 7. Pericarditis never met with. 8. Paralysis very frequently follows diphtheria. Bretonneau, and nearly all the French writers, consider diphtheria and croup as identical, particularly as croup in France is, like diphtheria, considered a contagious disease. I have for many years entertained the same views. Diphtheria. 55 Distinguishing characteristics between Diphtheria and Thrush, the Muguet of the French:— Diphtheria. J. In diphtheria there is great force of cohesion in the membrane. True membranes are formed. The ad- The ad- hesion of the tis- sues is such that we are rarely able to detach them without causing the raw part covered by them to bleed freely. 2. The diphthe- ritic product has the greatest ten- dency to propagate itself over the mu- Thrush (Muguet). 1. Thrush pre- sents itself in the form of small white points, at first dis- tinctly separate from each other, then joining, and constituting a white soft membrane, which is easily wiped away; the surface underneath being only inflamed and not raw, does not bleed. 2. Thrush chiefly affects the mouth, pharynx, and ali- mentary canal; never extends to 56 Diphtheria. cous membrane of the larynx or trachea. the air passages, where its presence constitutes croup proper. 3. The first ap- pearance of diph- theria is preceded by a very circum- scribed irritation of the parts of the mucous membrane, which are com- pletely covered by the membrane in its early stages of development. GRA 4. Diphtheria is preceded by a se- rous exudation, is never developed above the epidermis, and always adheres with marked tena- city to raw parts. 1 3. Thrush is in- variably preceded by general inflam- mation of the mu- cous membrane of the mouth, charac- terised by redness and great sensi- bility, which is a serious obstacle to suckling in young children. 4. Thrush is never preceded by a se- rous exudation, but it appears in the mucous membrane. when still covered with its epithelium. Diphtheria. 57 Distinguishing characteristics between Diphtheria and Croup, as suggested by Emphis and others :- Diphtheria. 1. Depends upon a peculiar blood- poison. 2. Diphtheria commences in the fauces, and only reaches other parts of the body by ex- tension. 3. In the first stage the cough is dry and sharp, and the voice is low. 4. Insecond stage breathing becomes difficult and cough moist. Croup. 1. True croup is apparently uncon- nected with any blood crasis. 2. True croup commences in the larynx and trachea, and stops there till it kills, unless re- moved by judicious treatment. 3. In true croup first stage, the voice is frequently almost extinguished. 4. In second stage the cough has a dry ringing metallic sound, with fits of suffocation. : ! 58 Diphtheria. The membrane formed by a blistered surface bears a stronger resemblance to the diphtheritic membrane than any other I know of; both are fibrinous, both are of a yellowish-grey colour, both are tough, and both adhere closely to the affected parts. The peculiar character- istics of the diphtherial membrane are that it is of a plastic fibrinous nature, appearing first on one spot, but will ex- tend to any excoriated surface or mucous membrane, the surface underneath pre- senting to the eye a highly vascular, corroding looking ulcer, and to the nose the most offensive odour. A. TREATMENT. Having now briefly reviewed the main features connected with the his- tory, symptoms, causes, and pathology of diphtheria, I shall at once proceed to discuss the remaining and most im- portant section of this little treatise- Diphtheria. 59 namely, its treatment. In the treat- ment of this terrible malady I have in- variably adopted the following rules as my guide, with a success which has far exceeded my most sanguine expecta- tions. a. The adoption of preventive or pro- phylactic means, general hygiene, with the selection of suitable baths and diet as applicable to its different stages. b. A careful selection of such specifics as mark their symptomological simi- larity to its peculiar characteristics. c. A judicious selection of topical remedies, and such as possess the largest amount of solvent and disin- fecting properties. In view of the general facts, which seem to be now well established, that defective drainage, impure water, impure milk, stagnant pools, and ditches where animal and vegetable matter have been allowed to accumulate and decompose, 12 Spide 60 Diphtheria. is a fruitful source from whence the contagious poison may emanate, such defective causes should at once be re- medied. In view also of the facts now clearly understood that many families exhibit a hereditary or an acquired pre- disposition to pharyngeal, laryngeal, and bronchial affections; that such affections are favoured by certain con- ditions of weather, especially sudden changes of temperature, and by the pre- valence of north and north-east winds, and that the disease we are now inves- tigating is undoubtedly of a very con- tagious nature, as proved by the “fatal kiss" which has cast a gloom over this land, and a nation into a house of mourning; it becomes an imperative duty on the part of every medical man to study carefully the laws that regulate the movements of epidemic and con- tagious diseases, and protect the system by certain prophylactic measures. We Diphtheria. 61 know that scarlatina, small-pox, ague, Asiatic cholera, measles, and yellow fever, have their respective prophylac- tics in Belladonna, Vaccination, Quinine or Arsenic, Camphor or Cuprum, Pulsa- tilla, Eucalyptus Globulus or Carbolic Acid, as amply proved by many phy- sicians in the West Indies and the Southern States of America. When such a predisposition exists in a child, it should be gradually and cautiously sub- jected to a process of hardening, for which purpose nothing is better than cold ablutions of the neck and chest, or a cold bath, saturated with Tidman's sea-salt, or a little vinegar. This should be begun early in life, and persistently and systematically carried out, together with the use of cold water gargles two or three times a day. The clothing should be selected with due regard to the age, temperament, and season of the year, never permitting a child to go out of ! : Diphtheria. doors when a north or a north-east wind prevails-a frequent cause of croup. If the family, on the father's or mother's side, have at any time exhi- bited a tendency to pharyngeal or laryngeal troubles in the form of a ringing metallic cough, such as may be compared to the crowing of a cock or the noise made by a fowl when caught in the hands; or a crowing inspiration, with paroxysms of spasmodic asthma, unattended with cough; the parents should be warned as to the risk of send- ing their children out of doors during the prevalence of cold, dry winds. Again, when an epidemic of diphtheria is raging in any neighbourhood, the frequent inspection of the mouth and fauces should be the primary duty of the local practitioner or parents, in order, if possible, to detect the first indi- cations of the disease; and when they have made their appearance, which may 62 Diphtheria. 63 only be in the slightest blush of redness, with perhaps a thin transparent coating of lymph, like the morning dew when rendered transparent by the solvent warmth of the rising sun, the patient should, without a moment's delay, be isolated from the rest of the family, and a strict quarantine observed. As soon as the first sign of a membranous exudation is observed in the mouth, whether on the pillars of the fauces, the tonsils, the uvula, or the soft palate, it should be treated with promptitude and energy. If the patient be old enough to use gargles, they should be used at once; such as a solution of Hydro- chloric Acid, Permanganate of Potash, or Terebene. If, on the other hand, the patient be too young, or have not learned the happy knack of gar- gling, the above-named fluids may be injected into the mouth by means of a female syringe, or, better still, by means 64 Diphtheria. of the usual ether spray, or, again, by an inhaler. In the case of restless or re- fractory children, a good-sized camel's- hair brush, a fine painter's brush, or a piece of sponge attached to a whalebone rod, saturated with the selected solu- tion, will will answer the purpose very well. The latter instrument is especially useful when it is found necessary to follow the enemy into the larynx and trachea, known as the probang. As far as the special allopathic treat- ment of laryngeal diphtheria is con- cerned, it is frankly admitted by the leading physicians of the day, that not- withstanding the great number of ex- ternal and internal remedies which have from time to time been used and re- commended, none exercise the slightest influence on the false membrane. Litera- ture has for centuries been inundated with them, but the real object has not in the least been advanced. Diphtheria. 65 Secondly, internal remedies. These should be selected from that group of medicines the pathogenetic effects of which upon the body in health bear the strongest resemblance to the constitu- tional symptoms and anatomical pro- duct of diphtheria. Amongst such medicines may be specially mentioned the Aconite, Belladonna, Mercurius Solu- bilis of Hahnemann, Mercurius Binioda- tus, Arsenicum, Bichromate of Potash, Spongia, Iodine, Lachesis, Hepar Sul- phuris, Cinchona, Senega, and Cantharis. The applicability of these medicines I hold to be somewhat as follows:- Aconitum Napellus.-This medicine stands foremost as a powerful antiphlo- gistic, and may well be described as the Lancet of Homœopathy. It checks fever, tones down the action of the heart, subdues internal congestion, and deter- mines the blood to the surface so as to promote free perspiration, consequently 66 Diphtheria. may be given with great benefit in the premonitory stage of diphtheria, and continued till the feverish symptoms have subsided. Atropa Belladonna.-This remarkable drug I look upon as almost specific in the milder forms of scarlet fever, sore throat, and in the milder forms of diphtheria. In scarlet fever it acts as a powerful prophylactic, as recorded in extensive statistics collected in various parts of the world, more particularly in Germany Its pathogenetic or toxicological effects give rise to a large group of symptoms which bear a close analogy to those of diphtheria; it produces that wild delirium which I have frequently observed in the early stage of the malignant type of the disease; it develops a yellowish-white deposit on the mouth and fauces; it causes inflamma- tion to appear on the tonsils, fauces, Diphtheria. 67 velum pendulum palati, and uvula; lan- cinating pains, and difficulty in swal- lowing, with a spasmodic constriction of the throat. But the deadly nightshade will not complete the graphic picture, with all its horrors, of true diphtheria; it will require a few finishing touches from one of the mercurial preparations to accomplish this. Mercury develops a filthy fœtor of the breath, most nearly resembling that of diphtheria; it causes a painful swelling of the glands of the throat, with profuse salivation; it pro- duces inflammation of the throat, fauces, uvula, and tonsils, which often terminates in a peculiar ulceration. Amongst its other pathogenetic effects, we find it producing a difficulty in swallowing; a feeling of suffocation, causing food and drink to regurgitate through the nostrils, through which also a putrid sanguineo- purulent matter occasionally flows. Finally, Mercury is capable of generat- 68 Diphtheria. ing a plastic fibrinous exudation around the fauces and adjacent parts, thus com- pleting as it were a true and graphic picture of diphtheria. Indeed such is the opinion I have formed of the efficacy. of these two remedies from an experience which has now extended from 1858 to the present time, that I am disposed to imitate the memorable words of Hahne- mann, when he proclaimed to the world the chief remedies for cholera, namely, Camphor, Cuprum, and Veratrum. If there be any truth in the homoeopathic law, Belladonna and Mercurius are the chief remedies in diphtheria, with Hydro- chloric Acid as a local application. Arsenicum Album.- This powerful and valuable medicine is well indicated both in the first as well as in the last stage of diphtheria when it assumes the malignant form. The physiologico-therapeutical range of Arsenic is only rivalled by the won- derful health-disturbing, and therefore Diphtheria. 69 health-restoring, properties of Aconite. Where Aconite seems to exercise its virtues on the surface of the organic functions, Arsenic acts on the inmost recesses of vitality. The Aconite fever is simple and evanescent; the Arsenical chill is deep, and seems to freeze the vital blood in the very laboratory of the heart. In typhoid fever Aconite is only of service in the mild form, Arsenic in the more severe and malignant form. The typhoid fever to which Arsenic is homœopathic is marked by the chills. being more racking, the fever heat more burning, the sweats more debilitating, the vital fluids more deeply affected by the morbid poison, the signs of decom- position more evident, with a manifest. tendency to the formation of sores and petechiæ. I may draw a similar parallel in every disease to which Aconite and Arsenic are homoeopathic. Take a case of Asiatic cholera, Aconite may be suffi- F 70 Diphtheria. cient to control a simple attack marked by mild symptoms, but it would require Arsenic to cope with the disease when it assumes a malignant form, marked by severe cramps, vomiting, and purging of rice-water stools, a marble coldness and lividity of the skin, excessive pros- tration, a collapsed pulse, with an un- quenchable thirst. Arsenic possesses the wonderful power of penetrating the very inmost recesses of organic life, and poisoning the very emanations of vitality as they diffuse themselves throughout the finest tissues. Arsenic is a potent remedy in certain forms of paralysis and epilepsy; in various fevers, such as the bilious remit- tent fever, gastric and mucous fever, and rheumatic fever, typhus and typhoid. The cure of intermittent and contagious fevers is one of the most brilliant triumphs of this preparation, which is fully endorsed by the majority of allo- pathic practitioners. Diphtheria. 71 The pathogenetic effects of Arsenic on the mouth are remarkably striking, and bear a very strong resemblance to the malignant form of diphtheria, a kind of angina gangrenosa. In this disease the tonsils become covered with a yel- lowish exudation, which soon changes to a greyish-yellow colour. This layer of exuded mucus frequently spreads over the back part of the pharynx, the inner surface of the cheeks, and even the lips. It may even involve the larynx, causing paroxysms of choking, and cough with expectoration of lumps of fibrinous shreds and matter. The breath has a cada- verous odour. There is fever, dulness of the head, a frequent pulse, a burning hot skin, and towards evening delirium. i There are few drugs that share with Arsenic the remarkable power to produce gangrenous disorganisation of the mu- cous membrane of the mouth, with the exception perhaps of the mercurial preparations. 72 Diphtheria. 1 Arsenic causes dryness and burning of the throat, with excessive pain when swallowing, and inability to do so. It causes great thirst, and a craving for cold drinks. It likewise causes all the croupy symptoms which may characterise the disease, particularly in its last stage. There is depicted the bluish colour of the lips and face, an expression of dis- tress and agony in the features, hoarse- ness, and at times total loss of voice, excessive wheezing, and agony of breathing, a feeble, tremulous, galloping pulse, and icy coldness of the extremi- ties. Taking into consideration the valuable medicinal properties of Arsenic in the various forms of fever of an epi- demic, endemic, and contagious nature, and its marvellous power of penetrating the minutest structures of the body, I claim for Arsenic a prominent position both as a preventive and curative agent in the various forms of diphtheria. Diphtheria. 73 Mercurius Biniodatus.-This prepara- tion should be given in preference to Mercurius Solubilis in broken-down con- stitutions, and those tainted with the strumous diathesis, or those who have been previously drugged with Calomel. It produces a fair picture of diphtheria. Lachesis.-This remarkable produc- tion of the animal kingdom may always be trusted as an auxiliary, in removing that distressing and painful sensation of strangulation and suffocation, as if at cord were tied tightly round the throat, which marks certain forms of scarlet fever, the phlegmonous sore throat, and diphtheria; indeed, I have never found Lachesis fail in this important symptom. Kali Bichromicum.-The action of this drug on the mucous membrane is quite as marked as Arsenic, Mercury, and Tartar Emetic. It produces a false membrane of a tough tenacious sub- stance on the fauces, the nares, larynx, 74 Diphtheria. trachea, and bronchi, evidently showing its homoeopathicity to diphtheritic croup. Spongia.-Hahnemann, whilst proving the common sponge, in order to ascer- tain its relation to goître, brought to light the remarkable fact that it exerted a special influence on the larynx, indicated by hoarseness, tenderness, dry and pain- ful cough, and obstruction of respiration, as if a plug were there. This accidental discovery led Hahnemann to prescribe Spongia in membranous croup. You may, says the discoverer, first lessen the febrile symptoms and local inflamma- tion by a dose of Aconite, and you will but seldom need the aid of Hepar Sulphuris to complete the cure. Since these words were uttered, thousands of cases of true membranous croup have been cured by Aconite, Spongia, and Hepar Sulphuris. In diphtheria (which is so closely allied to the croup of child- Diphtheria. 75 hood), when it invades the windpipe, these three medicines are worthy of our most serious consideration. Iodine. This remedy has been recom- mended by Dr. Kidd and others as a curative agent in diphtheria, both in- ternally and by inhalation. I have given Iodine as recommended in three cases, one in 1859, and two six years ago, but as it did not appear to exercise any beneficial influence on the disease, I fell back on my faithful Belladonna ; Mer · curius and the Hydrochloric Acid as a topical application. Sulphur and Cinchona.-These re- medies I generally prescribe as auxili- aries; the former as an intermediate remedy when the system falls below par, is deficient in reactionary power, and will not respond to the action of the specific medicine. In such cases Sulphur acts in a very striking manner; and so will a Turkish bath, or a hot 76 Diphtheria. sponge bath saturated with vinegar or sea salt. Senega and Cantharis.-Although I have not given these medicines a prac- tical test of their ability to cope with diphtheria, still I have included them in the list of medicines as worthy the attention of the profession. Senega has been used for a long period as a remedy for croup, particularly in its last stage. It appears to influence the mucous membranes of the air passages in a marked degree, the secretion of which it promotes and modifies. On these grounds I infer that Senega might prove curative in certain cases of diph- theria, particularly when it invades the larynx and air tubes. Cantharides.-The similarity of the membranes produced by this insect to diphtheria has led many physicians to prescribe it exclusively in this disease. Thus we have depicted inflammation of Diphtheria. 77 the mucous membrane of the fauces and tonsils, difficulty in swallowing, constric- tion of the larynx, ulcers and vesicles in the mouth, a fœtid breath, and profuse salivation. The local effects of this animal poison. are: 1. Inflammation, with heat, pain, red- ness, and some swelling. 2. The exudation of a light yellowish deposit, which becomes transformed into 3. A yellowish tough membrane. The injection of a small quantity of the Oil of Cantharides into the trachea of a dog will produce all the symptoms of croup, even to the development of a false membrane. LOCAL OR TOPICAL REMEDIES. Since the reappearance of diphtheria in the British Isles in 1858, a large number of nostrums have been thrust upon the notice of the profession and : 78 Diphtheria. the public as certain specifics, which when placed in the balance of experi- ence were found, in the majority of instances, to be perfectly harmless and worthless. Bretonneau recommended local blood- letting, emetics, blisters, and mustard poultices, with large doses of Calomel, with no satisfactory results. Pommiers, Alum, with the same re- sults. Trousseau, Nitrate of Silver, the Acid Nitrate of Mercury, Sulphate of Copper, and Hydrochloric Acid. Also Alum, Corrosive Sublimate, and the Chlorides of Potassium, Sodium, and Calcium. Greenhow, the Tincture of Sesqui- chloride of Iron, Borax, Alum, and Chlorate of Potash. Emphis, Hydrochloric Acid, Nitrate of Silver, and Nitrate of Mercury. Ranking, of Norwich, Hydrochloric Acid. į Diphtheria. 79 Ranking, of America, the Tincture of Chloride of Iron, Chlorate of Potash, and Hydrochloric Acid. Perry, Oil of Turpentine, and Car- bonate of Ammonia. Ramskill, a solution of Chloride of Lime. Bleyel, Lime-water. Sydenham, Sulphuric Acid. CHEMICAL EXPERIMENTS UPON THE MEMBRANE. Dr. W. T. Helmuth, St. Louis, U.S.A., has submitted the diphtheritic mem- brane to a series of tests, in order to ascertain its solvent properties under the influence of certain chemical agents, with the following results. 1. Experiment. The transudation is serum or lymph holding in solution albu- men; on adding Nitric Acid, a large quantity of albuminous matter is thrown down. 2. The Tincture of Perchloride of Iron 80 Diphtheria. hardens the membrane, and converts it in about twenty-four hours into a shri- velled, black, dry, and tanned substance. 3. Nitric Acid in twenty-six hours partly decomposed it; and in thirty-six hours the continuity was destroyed, the substance being separated into flakes. 4. Hydrochloric Acid first hardens and shrivels the membrane, but in eight hours the continuity of the substance is entirely destroyed. 5. Sulphuric Acid softens and reddens the solution, throws down a slight pre- cipitate, but does not decompose the membrane. 6. Benzoic Acid and Fluoric Acid pro- duce a similar effect to Nitric Acid, but take a longer time. 7. Caustic Ammonia dissolves the membrane in the short space of twelve. minutes. 8. Caustic Potash in the course of a few hours. { Diphtheria. 81 9. Hydrocyanic Acid in about thirty minutes. 10. Chloride of Zinc hardens and blackens it, and renders it more friable. 11. Phosphorus and Lime-water whiten the membrane, and cause it to separate into flakes in about thirty hours. From these interesting experiments it will be seen that Caustic Ammonia, Hy- drocyanic Acid, Hydrochloric Acid, and Caustic Potash, are the most rapid sol- vents of the diphtheritic membrane. Hydrochloric Acid appears to me to be more closely allied in its homoeo- pathicity to diphtheria than any of the others. Irrespective of its antiseptic and anti-contagious effects upon the internal organism, the Acid, if applied in a concentrated form to the healthy mucous membrane, develops a fibrinous inflammation. A superficial touch first whitens the epithelium, which becomes detached and renewed without causing 82 Diphtheria. a raw surface; but if the action of the Acid is prolonged, it develops an angry, irritable ulcer, which is covered by a whitish-yellow membrane. This Acid, like Nitric and Sulphuric Acid, does not quickly dissolve the membrane, but har- dens, shrivels, and detaches it. There is, however, a class of topical remedies which do possess the power of quickly dissolving and converting these mem- branous exudations into a transparent, diffluent fluid; namely, the Caustic Ammonia, alkaline solutions, Glycerine, and a weak solution of Rennet and Hy- drochloric Acid, which will quickly dis- solve the hardest fibrine. So will Lime- water in from ten to fifteen minutes. The Hydrochloric Acid, however, to my mind, stands foremost in the ranks. of topical remedies; it was the first that I selected on my first acquaintance with diphtheria in 1859; it has since been used by a large number of allopathic and homoeopathic physicians in this and Diphtheria. 83 other countries. It is one of the chief remedies recommended in Ziemsen's great work on the "Practice of Medi- cine;" and in a strongly written article on Diphtheria, by Dr. Heslop, which appeared in the "Medical Times" for May, 1862, he did not lose a case out of a large number, after adopting the use of Hydrochloric Acid. HYDROPATHIC APPLIANCES. In addition to the remedies enume- rated, I desire to draw the attention of my readers to the use of sweating baths and hot or cold appliances as valuable and powerful auxiliaries in the treatment of diphtheria. The skin, the natural functions of which are of such vital importance to health and the well-being of the animal economy, should not be overlooked or neglected. The allopathic physician is quite alive to this fact, when he pre- 84 Diphtheria. } scribes for his fever patients cooling salines and sweating medicines. The skin in diphtheria is dry, hot, and even parched; there is at times great thirst; the urine is to a great extent suppressed and high-coloured, and the bowels are costive; in fact, every outlet for the exit. of the impurities of the body is her- metically sealed, which enables the poison the more effectually to work out its deadly mission and paralyse the very mainsprings of life. It therefore becomes incumbent upon the physician to avert such a catastrophe in the shortest pos- sible time, by throwing open the seven millions of pores which stud the surface of the body, and by acting on the other secreting and excreting organs without a moment's delay. This can effectually be done by means of the Turkish, hot air, or the vapour bath, and as soon as free perspiration sets in the patient should drink copious draughts of cold ¡ : Diphtheria. 85 water, holding in solution some Per manganate of Potassia, Terebene, or Thymol. Let the bath be repeated every seven or eight hours, and should symptoms of exhaustion or faintness set in, rouse the nervous system by means of a cold shower or douche, and a diffu- sible stimulant, namely, camphor, brandy, or champagne. I have seen a free and energetic action of the skin cut short the mad career of a severe fever. Why not diphtheria? Hot or cold compresses to the throat, which should encircle the neck, I also look upon as valuable ad- juncts in the treatment of local diph- theria. I generally use the ordinary compress, or spongio-piline, saturated with a hot or cold solution of Camphor or Terebene; these applications act both as disinfectants and local vapour baths, which render the skin soft, moist, and yielding, and so relieve the pain and tension caused by the enlarged glands G * C 86 Diphtheria. ¡ and diffused inflammation of the sur- rounding parts. The hygienic treatment should con- sist in placing the patient in a large and well-ventilated room having an abun- dance of fresh air, with a temperature of about 64° to 68° Fah.; and in order to keep up a certain degree of moisture in the air it is well to place several vessels filled with water in the room, holding in so- lution Terebene, Permanganate of Potass, or Carbolic Acid. All superfluous furni- ture, bed and window curtains, should be removed; the bed linen should be fre- quently changed; all soiled linen should be immediately subjected to a strong disinfecting process, and the excreta also. The dietetic treatment should be se- lected with due regard to the strength and temperament of the patient, the height of the fever, the general habits of the sufferer, as well as the appetite. In most cases it should consist of bland Diphtheria. 87 nourishing food in a concentrated form, such as veal, chicken, or mutton broth, or beef-tea, thickened with a little pearl barley or rice, and flavoured with a wine- glassful of good dry sherry, port, or burgundy; in other cases a selection may be made of fresh milk, eggs, coffee, arrowroot, tapioca, sago, or Scotch oat- meal, with some of the light kinds of meat and wheaten bread. A very ex- cellent beef-tea can be made by selecting equal parts of beef, mutton, and veal, subjecting the ingredients to the same process as if only one were used; the mutton and veal tone down the harshness of the beef, and render the last softer and more mellow; with this view I shall designate it the "Triple Alliance." When symptoms of exhaustion set in we must not be sparing in stimulants, or the liberality and generous quality of the food; neither should we flag in our baths-particularly the ordinary pack 88 Diphtheria. wet cold-sheet bath, which is often fol- lowed by free perspiration and renewed strength. CASES ILLUSTRATIVE OF TREATMENT. CASE I-Simple Diphtheria. Oct. 4th, 1858. Thomas B., æt. 4 years, a stout, healthy-looking boy, had been ailing for two days. The pre- monitory symptoms, as described by the mother, were listlessness and rigors, followed by headache, a flushed face, hot skin, thirst, and swelling of the parotid glands, with high-coloured and scanty urine. On the third day of his illness (Oct. 4, 1858), I first saw him. The skin and lips were hot and dry, the face flushed, the neck swollen, he looked wild, and appeared frightened; he was thirsty, the tongue was coated and tremulous; the left tonsil was enlarged, Į Diphtheria. 89 inflamed, and studded with small white spots (diphtheritic deposits); the uvula and left palatal region were also in- flamed, the former covered by a whitish membranous crust, about the size of a sixpenny-piece, but oblong in form; the breath was highly offensive; the pulse was quick and small; the bowels costive; the urine high-coloured and scanty. My treatment consisted in the applica- tion of dilute Hydrochloric Acid to the exuded surfaces; the administration of Belladonna and Mercurius Solubilis (2 dec.) in alternation, every half-hour; and a hot compress (spongio-piline) to the neck. On the following day he was less feverish, and had perspired freely for some hours during the night; the swell- ing in the neck was reduced in size, and less tender; the tongue looked cleaner along the sides, but coated along the dorsum; the membranous deposit on -< 9o Diphtheria. the uvula was shrivelled, exposing un- derneath a bright red surface; the white spots on the tonsils had disappeared, exposing bright red depressions, the size of the exudations; he had passed water freely, and of a lighter colour; the bowels continued costive. The same mode of treatment was continued, the medicine being administered at longer intervals. On the third day (Oct. 6) he was better; the tongue looked cleaner; the swelling of the neck had considerably decreased; the tonsils and uvula looked healthy; the bowels were moved co- piously; the urine was clear and copious. The same treatment was continued, using the acid in a more diluted form. On the fourth day (Oct. 7) he was much improved. To take China (1 dec.) three times a day, for three days. On the seventh day (Oct. 10) he was convalescent, and was ordered to take China (2 dec.) twice a day, for a week. Diphtheria. 91 CASE II-Malignant Diphtheria. Oct. 15th, 1858. I saw a stout, phlegmatic boy, æt. 3 years, of a scrofulous diathesis, who had been ill four days before I was sent for. The early symptoms, as related by his mother, were as follow:-On the first day he appeared "out of sorts;" was fretful and peevish; complained of chills; sat on his mother's lap all day, or clung closely to her side. On the second day he was feverish; the skin became hot and dry; he called fre- quently for water, and drank it with avidity; he looked wild, had slight delirium, moaned and ground his teeth when asleep; he passed but little water, this only in drops, and highly coloured. On the morning of the third day he was no better; he had passed a restless night; the skin was burning hot; there was constant thirst. Towards noon, a - 92 Diphtheria. rash of a dark hue, with specks like flea- bites, appeared on the chest and thighs, remaining about an hour, and then sud- denly disappearing. This was followed immediately by symptoms of a more alarming nature; the throat began to swell; the breathing became hurried and laboured; the child winced and cried while swallowing. These symp- toms increased in severity every hour; and at half-past 9 p.m. on the following day (the fourth) I was first called in. I found him lying on his back, on a small temporary couch in the corner of a hot and closely-packed room, surrounded by his parents, a number of children, and several neighbours. He seemed in the agonies of suffocation; the sides of the neck and face were enormously swollen; the eyes glassy, the lids half closed; the lips dry and cracked, and coated with dark-brown "sordes:" the corners of the mouth were excoriated, and covered I Diphtheria. 93 with an aphthous deposit; a dark acrid discharge escaped from the mouth; the jaws were firmly clenched. On opening the mouth-a somewhat difficult task- the tongue presented here and there yellowish brown patches; other parts of that organ were red, dry, glossy, and cracked. The tonsils were enormously swollen, forming a complete embank- ment between the mouth and pharynx. The hard and soft palate, uvula, fauces, tonsils, and the whole of the buccal cavities, were lined with a cream-coloured. membrane; the breath was very offen- sive; a rattling suffocating noise at- tended the efforts of respiration, the breathing being chiefly carried on through the nasal cavities, from whence a constant discharge of muco-purulent sanguineous matter poured forth; the skin was hot and dry; the pulse quick, small, and fluttering; the urine scanty and turbid; the bowels relaxed and Sta 94 Diphtheria. offensive. Before commencing the treat- ment, I had the child removed to a cool and well-ventilated room; a band of spongio-piline, saturated with hot water, was applied round the neck; one drop of the 2nd decimal dilution of Belladonna was administered every half-hour, in alternation with one grain of Mercurius Solubilis (2nd decimal trituration). Owing to the difficulty in opening the child's mouth sufficiently wide to receive the powder, this medicament was admin- istered in the form of a "linctus," pre- pared by thoroughly mixing 20 grains of the trituration with six teaspoonfuls of simple syrup, and introduced into the mouth by means of a feather. I left the little sufferer about half-past 10 p.m., with but slight hope of ever seeing him alive again. Oct. 16th.-At 7 a.m. I visited the patient, and found him somewhat better. He had passed a terrible night; the ↓ Diphtheria. 95 mother had been most assiduous in carrying out my instructions; and every dose of the medicine, according to her statement, appeared to aggravate the symptoms. This state of things con- tinued until 5 a.m., when a change for the better was observed; the dyspnoea and symptoms of suffocation were some- what diminished; in other respects he was the same. At 9 p.m. I again saw him, and found a marked improvement; the dyspnoea was less distressing, the face and neck less swollen; the tongue less coated, but still exhibiting a cracked and ulcerated condition; the lips and teeth were loaded with sordes, and the discharge from the nostrils still con- tinued. The hot application to the neck was kept up; the Belladonna was omitted, and Arsenicum (third decimal trituration) substituted, and adminis- tered in alternation with the Mercurius. Oct. 17th. This day he was better. 96 Diphtheria. 1 He had passed a good night; the breathing was more free; the neck had visibly decreased in size; the tonsils smaller; the tongue slightly moist, but studded with small ulcers; the diph- theritic deposit in the mouth was disap- pearing gradually; the discharge from the nostrils was still profuse, but not so offensive; the bowels were regular, and the urine tolerably healthy. I ordered the same treatment to be contiuued. Oct. 18th.-He had passed a some- what restless night, but was better when I saw him. The breathing was more natural; the tongue looked cleaner, and the ulcers put on a healthy granulating appearance; the bowels had been moved naturally. Continued the same treat- ment. On the fourth day (Oct. 19) he was still improving. He had slept soundly in the night; the tongue was clean and moist, and the ulcers almost healed. To Diphtheria. 97 continue the same treatment. On the fifth day (Oct. 20) he was going on well. To take Mercurius Solubilis every four hours. On the sixth day (Oct. 21) I did not see him. On the seventh day. (Oct. 22) he was going on well. I ordered him Sulphur every night and morning for three days. On the eleventh day (Oct. 26th) he was again seen, and I prescribed China night and morning for four or five days, when I gave up further attendance.* CASE III-Simple Diphtheria. Oct. 17th, 1858.-Emma L., æt. 6, a thin, delicate girl, first showed symp- toms of indisposition on the second day * This boy was one of a family of five, only one of whom besides became affected with the disease, viz., a girl six years old, the subject of the following case. I may here observe that Belladonna and Mercurius (5th dec.) were administered to the whole of the children, as prophylactics, from the first moment of my attendance. 1 98 Diphtheria. of my attendance on her brother (see Case 2). There was no eruption in this case; she complained of headache and pains in the back; she looked wild; had a glassy appearance about the eyes; she was feverish, and the face flushed. There was slight enlargement and tenderness of the cervical glands, with pain and difficulty in swallowing ; she felt as if a cord was tied slightly round the neck; the tongue was tremu- lous, red at the sides, and coated in the centre; the pulse quick; the tonsils enlarged and red, as well as the fauces, the former being covered with a white exudation; several spots of the same kind appeared on the soft palate; she was thirsty; the bowels were tolerably regular; the urine scanty and high- coloured. The treatment consisted of the appli- cation to the neck of a collar of spongio- piline, saturated with hot water; paint- Diphtheria. 99 ing the diphtheritic surfaces with dilute Hydrochloric Acid; and the administra- tion of Lachesis and Mercurius Solubilis in alternation every hour. On the following day (Oct. 18th) she was better, was less feverish, and swal- lowed better; there was no increase of the diphtheritic deposit. The treat- ment was continued, and the medicines administered at longer intervals. On the third day (Oct. 19th) there was a further improvement. On the fourth day (Oct. 20th) improving still, but there remained some slight redness of the tonsils. Belladonna every four hours. On the fifth day (Oct 21st) she was much better, when I prescribed Sulphur night and morning for four days, after which she was quite convalescent. CASE IV. Nov. 15th, 1858.-S., the wife of a distinguished officer, consulted me on the 2 * : } * * * A 100 Diphtheria. K morning of the above date. This lady was 55 years old, stout, and of a highly bilious temperament. She was subject to quinsy, and had had about twenty attacks in the course of her lifetime. When I first saw her, she complained of sore-throat, pain, and a sense of con- striction in swallowing. I found en- largement and inflammation of the tonsils; these, with the uvula and soft palate, being of a purplish-red; she was very subject to congestion of the liver, and much troubled with costiveness; the pulse was quick and full, the tongue coated, and the breath offensive. Bella- donna and Mercurius (2nd decimal) were prescribed. On the following day (Nov. 16th) there was more fever; the breath was more offensive, and the throat symptoms much the same. Aco- nite and Belladonna (2nd decimal) were ordered to be taken every hour in alternation.. On the third day (Nov. i 1 Diphtheria. 101 17th) she was less feverish, the throat symptoms being somewhat better. I now gave Hepar Sulphuris 6. On the fourth day (Nov. 18th) I found no change in the symptoms, but continued the medicine. On the fifth day (Nov. 19th) she was not so well; she had passed a restless night; she complained of a good deal of pain in swallowing, and a feeling of strangulation; the tonsils were considerably enlarged; the soft palate presented a bright red ap- pearance, and covered with glairy mucus, not unlike the white of an egg; the breath continued offensive. Lachesis and Hepar Sulphuris were prescribed, a dose, alternately, every hour. On the sixth day (Nov. 20th) she was not so well; the symptoms had assumed more aggravated form, the feeling of constriction had increased, and there was greater difficulty and pain in swal- lowing; she was heavy and drowsy; a H 102 Diphtheria. 1 the tongue felt rough, but not much coated; the conjunctivæ yellow, the blood-vessels congested; the bowels were costive; the tonsils, uvula, and soft palate of a purplish-red colour, and covered here and there with patches of diphtheritic deposit; the breath highly offensive. A powder containing ten grains of the first decimal trituration of Podophyllum was administered at once, with the view of relieving the congested state of the liver. Afterwards the fol- lowing medicines were given: three drops of pure Bromine, mixed with eight ounces of water, and three grains of the first decimal trituration of Bichromate of Potassium, dissolved also in eight ounces. of water, a tablespoonful to be taken alternately every hour. She was also advised to inhale the steam of boiling water, in which Hydrochloric Acid had been dissolved. On the seventh day (Nov. 21st), morning, she spoke with Diphtheria. 103 difficulty; the tongue was swollen, and covered with a thick brownish mucus; a copious discharge of offensive pus was evacuated from an abscess which had formed in the posterior palatine region, with marked relief to some of the symp- toms. The bowels were freely moved, the fæces being highly charged with dark acrid bile; she passed a fair quan- tity of water; the diphtheritic membrane had spread over the greater part of the roof of the mouth. Belladonna and Mercurius (2nd decimal trituration) were administered, in alternation, every hour. The mouth was for a time well gargled with warm water, with the view of encouraging a free discharge of pus and blood from the abscess; afterwards. a gargle of Hydrochloric Acid and water was used. I again saw her in the even- ing; she had passed a comfortable day, and had had an hour's refreshing sleep; the abscess had discharged freely, and 104 Diphtheria. she could swallow better; the bowels had again acted, and a quantity of acrid bile had been evacuated; she was weak, the pulse small and flagging. Continued the same treatment, and ordered mutton broth every two hours. On the eighth. day (Nov. 22) she was better, and had had a comfortable night; there was little or no pain in swallowing, the breath was less offensive, the tongue cleaner; the diphtheritic membrane had sepa- rated from the roof of the mouth and tonsils in flakes. The same treatment was prescribed, with the addition of beef- tea thickened with arrowroot, every two hours. On the ninth day (Nov. 23rd) she was not so well, although there was no increase of the diphtheritic deposit ; yet she complained of pain in swallow- ing, and a feeling of constriction in the throat. Lachesis and Hepar Sulphuris were administered in alternation every two hours. On the tenth day (Novem- Diphtheria. 105 ber 24th) she was better. Continued the medicine and gargle. On the eleventh day (Nov. 25th) she was improving. I continued the same treatment. On the twelfth day (Nov. 26th) she was much improved. To take Sulphur every four hours. On the thirteenth and fourteenth day she still progressed favourably. On the fifteenth day (Nov. 29th) she was not so well, and complained of slight irritation in the throat, with stiffness in the angle of the right jaw, where redness and puffiness were observed; she was also feverish. Aconite and Hepar Sul- phuris alternately every three hours was prescribed. On the sixteenth day (Nov. 30th) she was less feverish; the stiffness had increased, and a small abscess de- veloped itself at the angle of the jaw- this was opened, with marked relief; several specks of diphtheritic deposit were observed around this spot. Baryta Carbonica (3rd decimal trituration) was тоб Diphtheria. prescribed, a grain every three hours. On the seventeenth day (Dec. Ist) the patient was better; the abscess had dis- charged freely, and the diphtheritic specks had disappeared. To take Hepar Sulphuris every four hours. On the eighteenth day (Dec. 2nd) she was much improved, and from this date all symp- toms of diphtheria had disappeared; but her convalescence was slow, as, in addition to debility, consequent upon so severe an attack, she suffered from her old complaints, viz., a congested liver, constipation, and indigestion. CASE V. Nov. 24th, 1858.-J. C., æt. 12 years, the son of a pilot, had been ill three days. On the morning of the fourth day he was first seen by me. He looked heavy and drowsy; the eyes were lustre- less and the face puffed; the parotid and submaxillary glands were enlarged and Diphtheria. 107 tender. On opening the mouth, the first symptom noticed was a stench of a most offensive character; the soft palate. and uvula presented a bright red appear- ance, and over a portion of this there was a yellowish-grey tenacious mem- brane several lines in thickness, about three-quarters of an inch wide and about two in length; it bore a strong resem- blance to a piece of wash-leather or wet parchment, and hung down like a veil. A portion of it having been detached by means of the handle of a spoon, the exposed surface looked highly con- gested, and drops of blood oozed from it. The tonsils were enlarged, and par- ticularly the left one, to which side the diphtheritic deposit was chiefly con- fined; deglutition was painful and diffi- cult; the tongue was thickly coated with dark-coloured mucus; the pulse full and quick (about 95); and there was general tremor and fever. 108 Diphtheria. The treatment consisted of the local application of dilute Hydrochloric Acid three or four times a day, and the ad- ministration of Belladonna and Mer- curius Solubilis (2nd decimal dilution and trituration) alternately every half- hour. On the following day (Nov. 25th) there was a favourable change; the diphtheritic membrane had nearly dis- appeared; the surface from which ex- uded this remarkable poison-growth now presented quite a different appear- ance, and instead of that which has not inaptly been compared to a piece of moistened parchment or wash-leather, now presented the appearance of a semi-transparent matter, doubtless a fresh exudation in its first stage of de- velopment; the efforts to swallow were less painful, the glands had diminished in size, the face had assumed a more natural appearance, but the stench from the mouth was but little diminished; Diphtheria. 109 the tongue was less coated, and the bowels had been freely moved in the course of the night. The same mode of treatment was continued, the medi- cine being administered at longer inter- vals. On the third day (Nov. 26th) there was a marked improvement in the condition of this boy; the breath was less offensive; he swallowed with greater ease and comfort; the tonsils and cer- vical glands had materially diminished; the exudation from the diphtheritic sur- face was altered in its character, now ap- pearing in the form of a thin glairy mucus; the bowels were relaxed, the evacuations very offensive; this I attri- buted to the irritation caused by his having swallowed fragments of the poi- sonous membrane. The Belladonna and Mercurius were continued at longer intervals; the Acid, also, but in a more diluted form, was used as a gargle. On the fourth day (Nov 27th) a further ITO Diphtheria. improvement had taken place; the diphtheritic surface presented a healthy appearance; the tongue was cleaner, and the glands further reduced in size, while the evacuations were healthy and natural in colour. The same course of treatment was continued. On the fifth day (Nov. 28th) I did not visit. him. On the sixth day (Nov. 29th) he was again seen; the change was most gratifying. He was rapidly progressing towards convalescence; the eyes were bright and natural; the cervical glands were nearly reduced to their natural size; the lips were red and moist; the breath had lost its offensiveness; the tongue was clean; the space covered by the diphtheritic membrane was fast returning to its natural colour; the ton- sils had considerably diminished in size; they looked healthy; the appetite was keen; the bowels regular. To take Sulphur (6) night and morning, for three Diphtheria. I 11 days, then China (2) twice a day for a week; when he was discharged cured. CASE VI While paying a visit to the subject of the last case on the 4th of December, my attention was directed to his sister, a stout, phlegmatic girl of 16, who com- plained of sore-throat, pain and difficulty n swallowing. A closer examination of the case revealed the following symp- toms. She complained of a dull, aching, throbbing headache; the eyes looked heavy; the face puffed, flushed, and shining; there was enlargement and tenderness of the cervical glands on both sides; the breath was offensive; the lips dry and cracked; she was feverish; the pulse full and quick (about 90); the tongue tremulous, and coated with a thick slimy mucus; there was consider- able ptyalism; the tonsils were enlarged, and of a bright red colour; the soft II2 Diphtheria. palate, uvula, and fauces partook of the same inflamed condition; the surface of these parts was dotted with diph- theritic deposit, and bore some resem- blance to a crop of small-pox pustules; some of these coalesced, and presented the usual characteristics of the true diphtheritic membrane; the bowels were regular; the urine scanty and turbid. The treatment consisted in the ad- ministration of Belladonna and Mercurius Solubilis (2nd decimal), and the appli- cation of dilute Hydrochloric Acid to the diphtheritic surfaces. On the second day (Dec. 5th) there was no increase of the diphtheritic exudation; some of the old deposits had disappeared; the tonsils were smaller, and the inflammatory blush over these and surrounding parts paler; the cervical glands had diminished in size and were less tender; she was less feverish; the tongue was cleaning from the tip she perspired freely during the Diphtheria. 113 night; the urine was passed in larger quantities, and of a better colour. To continue the same treatment. On the third day (December 6th) she was going on well. On the fourth day (December 7th) I did not see her. On the fifth day (December 8th) she was very much better, and I ordered her Sulphur (6) once a day for a week, when I gave up further attendance. CASE VII.-Malignant Diphtheria. Mr. G., æt. 32, a stout, well-built, florid looking man, consulted me on the 10th. of December, 1858. He complained of sore-throat, rigors, pains in the limbs and back. He attributed these symptoms to the effect of cold arising from expo- sure the day before. The mouth pre- sented nothing abnormal, save slight enlargement of both tonsils, and a blush of redness over the soft palate and fauces; his general health was good. Aconite (2nd decimal dilution) was prescribed, 1:4 Diphtheria. -a drop in a tablespoonful of water, every two hours. He was recommended to confine himself to the house for the day; to put his feet into hot water at night, and to take a basin of warm gruel. This treatment, for the time, appeared to have had the desired effect, for on the morrow he felt much better, rose early and went to work. Towards night he was not so well; the old symptoms had returned, but he took little notice of them, and merely used a simple gargle of his own prescribing and retired to bed. He passed a restless night, having had no sleep; the throat became more painful and swollen, and as the day advanced the symptoms became more alarming, which urged him towards evening to send for a medical man. At half-past seven I found him in a half-sitting pos- ture, in a general tremor; there was total prostration of all vital energy. He pointed. to his throat as the seat of all the mischief: the cervical glands were enor- Diphtheria. 115 mously swollen; the eyelids half closed; his eyes heavy and glassy; his face and neck red, shining, and puffy; his lips dry; the angles of the mouth exhibited superficial ulcerations; the jaws were stiff; the mouth could be opened with difficulty; the tongue was coated with a whitish-brown thick mucus; there was profuse ptyalism; his breath was tainted with that offensive odour so peculiar to diphtheria; his voice was hoarse; the tensils swollen, and presented, with the fauces, soft palate, and uvula, a dusky- red colour; the surface of these parts was studded with yellowish-white spots, the size of split peas; these spots ex- tended into the pharynx; the pulse was quick and throbbing; the urine scanty. and turbid; the skin dry and hot. I prescribed a hot compress of Spongio- piline, to encircle the neck; the admin- istration of Belladonna and Mercurius Solubilis (2nd decimal dilution and [16 Diphtheria. trituration), alternately, every half-hour, and the application to the diphtheritic surfaces of dilute Hydrochloric Acid every three hours. On the following day (De- cember 11th) he was no better; he had passed a very restless night; the diph- theritic spots had become larger and darker in colour, several having coalesced, forming patches; the breath was more offensive, and he had great difficulty in swallowing. The hot compress was kept to the neck and throat; the first decimal trituration of the same medicines was given, and the acid was applied to the membranes. The third day (Dec. 12th) brought no amelioration of the symp- toms save a slight diminution in the size of the neck, and greater facility in open- ing the mouth; the tongue was thickly coated; deglutition painful and diffi- cult; the tonsils touched each other; the diphtheritic patches were more de- veloped-one, in particular, about an Diphtheria. 117 inch long, adhered to the surface of the fauces like a piece of moistened parch- ment; the breath continued very offen- sive; the skin was hot and dry; the urine scanty and high-coloured. The same treatment was continued, and in addition, three drops of Aconite (2nd decimal) were administered at bed-time, with the view of subduing the fever. The fourth day (Dec. 13th) brought better news; although he had passed a distressingly restless night, yet he was easier towards morning, after a free and copious perspiration; the tongue was clean at the tip; the tonsils had somewhat diminished in size; size; the diphtheritic membranes were darker in colour, and shrivelled; he could open his mouth better; the pulse was softer, and not so quick; the urine was lighter in colour, and more copious; he had an offensive discharge from both nostrils; the breath was equally offensive. The I 118 Diphtheria. } same treatment was continued. On the fifth day (Dec. 14th) there was no change in the symptoms. I continued the treatment. On the sixth day (Dec. 15th) he was better; there was a marked amelioration of the symptoms. Con- tinued the same treatment. On the seventh day (Dec. 16th) he was much bet- ter; the discharge from the nostrils had diminished; the tongue was cleaning from the tip backwards; the tonsils were smaller, and the diphtheritic mem- branes dropping off in shreds; the breath was still offensive; the neck was smaller; the pulse soft, and about 85; the urine clear and copious; bowels regular. To continue the same medicine, and use the acid as a gargle. On the eighth day (Dec. 17th) progressing favourably; continue the same treat- ment. On the ninth day (Dec. 18th) going on well; to continue same treat- ment. On the tenth day (Dec. 19th) Diphtheria. 119 improving; the diphtheritic membrane. had all but disappeared; the discharge from the nostrils had ceased; the tongue moist, and cleaning nicely; the tonsils smaller, and the neck reduced in size ; the urine clear, and the bowels regular. To go on with the same medicine. On the eleventh day (Dec. 20th) going on well. To repeat the same medicine. On the twelfth day (Dec. 21st) I did not see him. On the thirteenth day (Dec. 22nd) he was again seen, and was pro- gressing favourably. To take China and Sulphur, and to continue the gargle. These he took and used for three days, when I again saw him; was much im- proved. The same treatment was con- tinued for another week, when he was declared well. My paper contains three more cases; but as they present no very important features, I shall merely give a general outline of them. 120 Diphtheria. CASE VIII.-Simple Diphtheria. The first was that of a boy, æt. 5 years, who had been ailing four or five days before I saw him. His breath was very offensive; tonsils swollen; tongue coated and tremulous; pulse quick and small. On the soft palate there was a strip of yellowish-brown membrane, of considerable thickness; this was re- moved by grasping the upper end with a forceps, and gently tearing it away from above downwards; the denuded surface was highly vascular, presenting a very irritable appearance, not unlike the irritable ulcer or chancre. This case was treated with repeated doses of Belladonna and Mercurius, the diph- theritic surface painted with dilute Hydrochloric Acid; was no renewal of the membrane, and the child was well in seven days. Diphtheria, 121 CASE IX.-Simple Diphtheria. The second was that of a lad 7 years old. He also had been unwell for some days before I first saw him. In this case the left tonsil and uvula were alone affected, being covered with a yellowish- grey coating, some lines in thickness; a blush of redness was diffused over the soft palate of the same side; his breath was very offensive; tongue coated edges of the alæ nasi ulcerated; slight salivation. This case was treated with Belladonna and Mercurius, and the ap- plication of Hydrochloric Acid. On the second day the membrane looked darker and puckered, 'On the third day darker still and shrivelled. On the fourth day of a dark brown, and partially detached. On the morning of the fifth day during a fit of coughing, it became entirely detached, The Belladonna and Mercurius were continued, the diphtheritic I22 Diphtheria. surface painted night and morning with the acid, and at the end of ten days he was well. CASE X.-Malignant Diphtheria. The third case was that of a little girl 9 years old, of a strumous habit. In this case the cervical glands were seriously implicated; the neck was puffed out; there was also dyspnoea and salivation ; the tonsils touched each other, and covered with a membrane about the size and form of the bowl of an egg-spoon, of considerable thickness and of a yellowish-grey colour; she was feverish; skin hot and dry; thirst; bowels costive; urine high-coloured, and scanty; the hot compress was applied to the neck. Belladonna and Mercurius Biniodatus (2nd dec.), in alternation, were administered every hour, Aconite (3) at bedtime, and the membrane painted with the acid. On the following day, higher state of Diphtheria. 123 fever; all secretions suppressed; intensel thirst; tongue like leather; and every outlet of the body sealed up. I ordered a hot bath with mustard; this was followed by profuse diaphoresis; urine and bowels were freely evacuated. Con- tinued the medicine and acid. She improved daily under this treatment, and at the expiration of fourteen days was convalescent. + APPENDIX. ; PRESUMING this little "monograph will fall into the hands of many who believe in the principles of Homœopathy, and who might perchance be compelled "on an emergency" to treat a case of diphtheria, I append here a list of those remedies which proved so efficacious in my hands, coupled with brief instruc- tions as to the mode of applying the local medicaments. At the same time I would strongly advise non-medical persons, if possible, to avoid coping with so formidable and malignant a disease. The selection and symptomatological effects of the drugs will be found por- "J 126 Appendix. trayed at from page 65 to 77, and the repetition of the dose scattered through the pages wherein are contained the cases, from page 88 to 133. Name. Potency chiefly employed. Tincture, 2 dec. dil. Trituration, 3 do. Tincture, 2 & 3 do. Tincture, 2 & 3 do. Sol., Trituration, I & 2 do. Aconitum Napellus Arsenicum Album Belladonna China Mercurius Hah. Mercurius proto- iodidus Lachesis Sulphur Hep. Sulph.. Trituration, 2 do. Dilution, 5 cent. Dilution, 5 cent. Dilution, 5 cent. The remedies in the above list are the most efficacious hitherto tested, so long as the disease confines itself within the cavity of the mouth; but should it escape into the larynx and attack the air-tubes, or primarily develop itself there, then Appendix. 127 the following will be found the most suitable remedies :- M Bromine Tincture p 3 drops in a tumblerful of pure water. Bichromate of potass Trituration, I dec. Iodine. Tincture, 4 drms. Boiling water, i pint, mix; to be administered by inhalation. Or, Iodine Spongia Senega Cantharis. were- Tincture, 3 decimal. Tincture, 6 decimal. Tincture, 3 decimal. Tincture, 3 decimal. The local remedies I found so useful Firstly.-Constant warmth applied to the neck by means of spongio-piline, saturated in hot water, and renewed as often as the temperature became lowered. Secondly.-The application of dilute Hydrochloric Acid to the false mem- branes. This was more or less modified, 128 Appendix. according to the stage of the disease and the condition of the diphtheritic deposit. When the membrane was thick, and thoroughly formed, I used a solution composed of one part of acid to three parts of water. When the deposit was thinner, and somewhat transparent, the solution consisted of one part of acid to four or five parts of water. And when it assumed the character of a glairy mucus, one part of acid to eight or ten parts of water. In slight cases, and during the stage of convalescence, I prescribed the acid in the form of a gargle, by mixing fifteen to twenty drops in eight or ten ounces of water. The acid as prescribed in the above formulas was applied by means of a strong and moderate size camel's-hair brush, care being taken not to allow any of it to escape into the larynx. Appendix. 129 The parts immediately bordering on the membranes should also be painted. with the same solution in a more diluted form. An artificial irritation of a “similar" kind is thus set up, which confines within a given circuit the mor- bid product. I am fully convinced that this precaution will frequently avert the spread of the disease and blunt its viru- lence, and afford time as well as aid to the action of the internal remedies. K A Diphtheria. 131 ANTISEPTICS, DISINFECTANTS, OR DEODORANTS. In order to make this Monogram as complete as its limits will permit, I ap- pend here a brief description of some of the leading disinfectants. Some have been long and familiarly known to the generality of persons; others are of re- cent invention, and according to eminent authorities are more potent and less dan- gerous as counteracting agents against miasmatic and other poisonous emana- tions. Among the old and familiar disinfect- ants we recognise the Chloride of Lime, Quicklime, Carbolic Acid, the Carbo- lates of Lime and Magnesia, and Per- manganate of Potash. In certain cases the Perchloride of Iron, Sulphate of Iron, 132 Diphtheria. Ammonia, Iodine, Bromine, Nitrate of Lead, and Chloride of Zinc (Sir W. Burnett's fluid) have been recommended. Or, again, Chlorine Gas and Sulphurous. Acid Gas, Charcoal or Dried Earth, have been suggested. No night-stools or bed- pans should be used without their con- taining a solution of Permanganate of Potash, or Carbolic Acid; Chloride of Lime, Chloride of Zinc, or half an ounce of Tincture of Iodine. The first agent has the advantage of not being corrosive, but the last is the most efficacious. The door and window must be thrown open so as to allow of a free current of fresh air. To disinfect linen and washing apparel, they should be soaked in a mixture of two ounces of the solution of Permanganate of Potash to one gallon of water, being afterwards plunged into boiling water. Woollens, bedding, or clothing may be thoroughly purified by exposing them Diphtheria. 133 for two hours in an oven to a tempera- ture of 220° Fahr. CHLORINE GAS.-As a fumigating, antiseptic, and disinfecting agent, this gas stands unrivalled. It is made by inti- mately mixing one part of table salt with one part of the black or Binoxide of Man- ganese, and placed in a shallow earthen- ware pan; to these is added two parts of Oil of Vitriol (Sulphuric Acid) pre- viously diluted with two parts of water, and the whole well stirred with a stick. The Chlorine Gas is now set free, which continues for three or four days. The utensils containing the ingredients should be placed in the highest part of the room, as it is the nature of this gas to descend by its own density, and become gradu- ally intermingled with the surrounding atmosphere. SULPHUROUS ACID GAS.-This ele- 134 Diphtheria. ment is obtained by sprinkling powdered Sulphur on a few bright-red coals in a shovel, or by burning part of a stick of Sulphur in a crucible, or in a pipkin. Powdered Charcoal or dry Earth may be used in the same way. · CARBOLIC ACID.-This preparation is known as Phenic Acid, Phenol, Hy- drate of Phenyl, and Phenylic Alcohol. It is obtained from Coal Tar by distilla- tion and subsequent purification, and sub- sides into colourless acicular crystals. It coagulates albumen, and does not redden litmus paper. MEDICINALLY.-It promotes free per- spiration, reduces fever, and lowers the pulse. In this respect it is an analogue to Aconite, consequently may be admin- istered as a disinfecting febrifuge in all kinds of eruptive, epidemic, and conta- gious fevers. Many physicians in the Diphtheria. 135 Southern States of America and the West India Islands administer Carbolic Acid as a prophylactic in yellow fever (Typhus Icterodes). In diphtheria it may be used as a preventive-one grain in water, taken night and morning; also as a gargle, by means of a spray, inhalation, or applied to the fauces once or twice a day. For- mula: 1 of acid to 100 of water. As a lotion to diphtheritic exudations on sores of mucous membranes. Formula: 15 to 30 grains to I ounce of water. And as a hypodermic injection, of a grain in 20 drops of water has been found efficacious in intermittent fever; why not in diph- theria? As a gargle it quickly destroys the fœtor of breath, which is a leading characteristic of diphtheria. Formula: 2 grains to I ounce of water. Carbolic Acid destroys the lowest forms of animal and vegetable life, and prevents fermentation and putrefaction. 136 Diphtheria. Unlike Chlorine and Permanganate of Potash, however, the acid is incapable of destroying offensive gases; it only prevents their formation. The astound- ing revelations made by Pasteur and confirmed by Sanderson, Braidwood, Hallier, and others, as to the existence of a contagium vivum as a cause of disease and putrefaction, and the destruc- tive element and antagonistic virtues. of the acid, renders it one of the most powerful antiseptics in the whole arena of disinfectants. It is now well proved that septi- cæmia, pyæmia, relapsing fever, splenic fever, carbuncles, chronic ulcers, indo- lent sloughing wounds, are caused by animalculæ, the bacteria, vibriones, or microzimes; parasites which exceed the twenty-thousandth part of an inch in diameter, and which are found in millions in the blood and excreta of those affected. It is also proved that Diphtheria. 137 cholera, typhus, measles, small-pox, typhoid, hooping-cough, and diphtheria, are caused by a parasitic fungus, which is found in large numbers in the excreta of those suffering from such complaints, for destruction of which, Carbolic Acid is represented to be one of the most effectual remedies. PERMANGANATE OF POTASH. Known also as Potassæ Permanganas, presents itself in the form of dark pur- ple, slender prismatic crystals, inodorous, with a sweet astringent taste. It is per- fectly soluble in water (I in ducing a rich purple colour. 16), pro- MEDICINALLY.-The Permanganate of Potash is a powerful antiseptic and disinfectant. It forms the basis of Condy's Antiseptic Fluid. It deodo- rises foul ulcers, cancers, and the diph- theritic fœtor; it corrects foetid effluvia, 138 Diphtheria. offensive evacuations and expectorations, when Carbolic Acid fails. Used as a gargle, inhalant, spray, or lotion, let the proportions be from one. to five fluid drachms of the officinal pre- paration to a pint of water. As a medicine, one to two grains in water two or three times a day. IODINE. This agent has been re- commended as a disinfecting agent, and to check the progress of diphtheria; it is used as an inhalant, and adminis- tered internally. Mg CAMPHOR. This medicine is an energetic diffusible stimulant; it acts as a powerful prophylactic, and curative agent in cholera and summer diarrhoea. It is worthy of a fair trial as a preventive in diphtheria; as a topical application, and as a curative agent in the stages of prostration and collapse. Diphtheria. 139 Camphor is a powerful antiseptic. A gentleman who enjoys the largest mid- dle-class and dispensary practice in London, uses no other than a solution of Camphor as a dressing for chronic ulcers of the lower extremities. I have witnessed the most satisfactory results. to follow such treatment. The micro- scope in such cases would doubtless reveal thousands of parasites (bacteria). The next group of disinfectants are those of recent discovery. They consist of Terebene, Cupralum, Terebene powder, and Thymol. 1. TEREBENE. This is comparatively a new and powerful antiseptic, disinfect- ant, and deodoriser; designed by Dr. Bond, Medical Officer of Health for Gloucestershire. Terebene is a liquid, with a somewhat camphoraceous smell in mass, resem- bling that of Oil of Thyme (Thymol). It 140 Diphtheria. is obtained by chemical means from the juice of the Resinous Pine (Pinus palus- tris), and some other coniferous plants. When exposed to the air it volatilises, emitting an odour of a fragrant and agreeable character, which when diffused through the atmosphere, somewhat recalls that of pine wood. When thus exposed it acts upon the oxygen of the air, developing ozone in it, and at the same time becoming itself charged with peroxide of hydrogen (antozone of Schönbein). When added to any decom- posing and offensive matter, Terebene acts as a powerful deodorant. It pro- duces the same effect upon a foul atmosphere, not simply by masking the offensive smell of its own odour, as in the case of Carbolic Acid, and other * "The sleep-givi g, soothing fragrance of t'e Resinous Pine, cleanest, sweetest, and most healing of all scents, fills the air."-Travels in the Rocky Mountains, by the Earl of Dunraven. Diphtheria. 141 similar strongly-smelling disinfectants, but by developing in the air an agent (ozone) which rapidly oxydises and destroys the malodorous emanations. It is therefore truly an atmospheric purifier. Terebene has also distinct antiseptic powers, and when added to putrescent matters, arrests putrefaction for a considerable time. It is non-poi- sonous, and may be taken internally with impunity. When thus taken it acts as an inward antiseptic, producing, in addition to other effects, the arrest to a great extent of fæcal putrefaction; the fæces becoming under its use almost entirely odourless, which is suggestive of its ap- plicability in various cases. It may be noted that Terebene is almost identical in its general physical characters and chemical composition with Thymol, the chief constituent of Oil of Thyme, ano- ther recently discovered disinfectant, of the antiseptic properties of which a 142 Diphtheria. very strong report will be found in the "British Medical Journal," May 2, 1875. So also with Salicylic Acid. When Terebene is gently heated it gives off a peculiar aromatic odour. By holding a saucer containing some over a candle, a most agreeable fragrance may be diffused through a sick-room. In diphtheria it may be used in the form of a gargle; topically by means of a brush or sponge; by inhalation or a spray. As a medicine it may be admin- istered several times a day, particularly when we suspect the disease has entered the stomach and intestines. W 2. CUPRALUM TEREBENE Pow- DER. This is another new and most powerful disinfectant, designed by the same gentleman. It is a compound of Terebene, Cupric Sulphate, Potassic Dichromate, and Alumenic Sulphate; thus forming a combination (according Diphtheria. 143 to the views of the designer) which is unsurpassed as a disinfecting agent in destroying emanations and infectious germs. This combination possesses in a higher degree than any other the power of developing ozone in the air, of coagulating albumen, of neutralising ammonia and sulphurated hydrogen, of destroying offensive odours, and of emitting an aroma which is distinctly agreeable and pleasant; a great boon in the sick-chamber. It should be chiefly used as a deodoriser. < THYMOL. This is another antiseptic and disinfecting agent of recent birth, which consists of a peculiar crystal ex- tracted from the Wild Thyme (Origa- num vulgare); it is pronounced by many eminent chemists and physicians to be far superior, and much stronger, than Carbolic Acid, or any other so- called antiseptic or disinfecting agents 144 Diphtheria. hitherto known, and has been proved by the experiments of Lewin and Bucholtz to be about eight times as powerful as Carbolic Acid. It has also a great advantage over the latter, like its pro- totype, Terebene, in being perfectly harmless and free from all poisonous constituents, and like Terebene also in possessing its own delicious and fragrant odour derived from the Wild Thyme MEDICINALLY.-It may be admin- istered as a medicine, and used as a gargle, lotion, inhalant, or spray, and also as a topical application. MOU INDEX. Aconite, therapeutic range, 65. pathogenetic effects in febrile stage, 65. Alice, Princess, death of, 17. Ague, springing from fens and marshes, 27. Allopath c treatment of diphtheria nil, 64. Appendix, 125. Aretæus, 24. Arsenic a powerful preven- tive of ague and cholera, 61. Arsenic, effects on mouth, 71. Arsenicum, range of, 68. Ash sore throat, 29. Ash, diphtheria very fatal a, in 1858, 28. Atropa Belladonna, thera- peutic range of, 66. Author's views of diph- tueria, 30. pathogenetic therapeutic Baths, Turkish or vapour, valuable adjuncts in treat- ment, 59. Belladonna, pathogenetic effects on mouth, 66. therapeutic range of, 66. Bichromate of potass, thera- peutic range of, 65. Boulogne sore throat, 28. Bretonneau's views of the identity of diphtheria and croup, 54. Camphor a powerful pre- ventive of cholera, 61. Canterbury, diphtheria very fatal at, in 1858, 28. Cantharides, local effects of, 76. Carbolic acid as a disinfect- ant, 86. Cases illustrative of cures, • 88. Causes of diphtheria, 26. 146 INDEX. Chemical experiments on membrane, 79. Chief remedies for diph- theria, 65. Cholera, springing from delta of Ganges, 27. preventives pointed out by Hahnemann, 23. Cinchona, therapeutic use, 65. Cuprum a powerful pre- ventive of cholera, 61. Deafness a sequel of diph- theria, 39. Deal, diphtheria very fatal at, in 1858, 28 Definition fdiphtheria, 39. Diagnosis of diphtheria, 39. Diagnosis absolute of diph- ( theria, 49. Diphtheria, history of, 24. - Authorities, Alaymus, 25. Aretceus, 24. Bard, 25. Bretonneau, 25. Cartesius, 24. Fothergill, 25. Hippocrates, 24. Villa Real, 24. Diphtheria analogous to other diseases, 45. sim lar to other diseases, 48. most terrible and less known than other dis- eases, 22. Diphtheria springing from decomposed animal and vegetable matter, 27. a peculiar fungous growth, 36. Distinguishing characteris- tics between diphtheria and other diseases. viz. : Scarlatina Maligna, 53. Thrush (Apthæ), 55. Croup. 57. Dover, diphtheria very fatal at, in 1858, 29. Emphis's characteristics of diphtheria and croup, 57. Gangrene a sequel of diphtheria, 38. Hæmorrhage a sequelæ of diphtheria, 38. Ha' nemann's theory of ho- mœopathy, 23. Hepar Sulph., its thera- peutic range, 65. Hereditary tendency to diphtheria, 62. Heslop's, Dr., views on diphtheria, 83. History of iphtheria, 24. Hydrochloric acid, mode of using, 126. best topical applica- tion, 82. Hygienic treatment, 59. INDEX. 147 In Memoriam, 3. Introduction, 17. Iodine, therapeutic range of, 75. Jenner, Sir W., theory of diphtheria, 40. mortality treatment, 40. under his Kali Bichromicum, its pa- thogenetic effects mouth, 73. on Lachesis, its pathogenetic effects on throat, 65. therapeutic range of, 73. ↓ Local appl cations- ગ્રી Trousseau, 78. Greenh w, 78. Emphis, 78. Ranking, 78. Perry, 79. Ramskill, 79. Ranking, 79. Bleyel, 79. Sydenham, 79. Loss of voice a sequelae of diphtheria, 39. Malignant diphtheria treat- ed successfully, 91. Medicines, list of, 125-127. Mercurius Biniodatus, the- rapeutic rauge of, 65. Mercurius Solubilis, thera- peuti: range of, 65. Mercurius, its pathogenetic effects on mouth, 73. Mode of using topical re- medies in children, 64. Otorrhoea a sequelæ of di¸h- theria, 39. Ozæna.a sequelæ of diph- theria, 39. Paralysis a sequelæ of diphtheria, 39. Permanganate of potas, therapeutic range of. 86. Plague springi gfrom Nile, lower Egypt, 17. Port wine, its uses, 87. Preface, 5. Premonitory symptoms of diphtheria, 69. Preventive local remedies, 63. Prophylactic remedies for diphtheria, 42. Scarlatina, 42. Measles, 42. Cholera, 42. Ague, 42. Yellow fever, 42. Syphilis, 42. Report of St. George's Hospital, 46. Rheumatism a sequelæ of diphtheria, 39. 148 INDEX. Senega, therapeutic range of, 76. Sherry, when required, 87. Spongia, therapeutic range of, 74. Spongiu-piline a substitute for poultice, 85. Squ nting a sequelæ of diphtheria, 39. Suffocation a cause of death in diphtheria, 38. Sul hur, therapeutic range f, 75. Supposed causes of diph- theria, 26. Symptoms of diphtheria- Premonitory stage, 34. Development, 38. Decline, 38. Sequelæ, 39. ין Tables of mortality, 43. Temperature of room, 86. Terebene, its therapeutic and disinfecting range, 86. Topical remedies, 77. Authorities- Trousseau Arg. -Nit., Acid. - Nit., Merc., Cup., Sulph., Hydr. Acid, Alum., Merc.- Cor., Pot. Chlorid., Sodium and Calcium, 78. - Bretonneau : Chiefly Alum, and Calomel, 78. Greenhow: Tr. Iron, Borax, Alumn., and Potas. -Chlorid, 78. Emphis: Acid. - Hydr., Arg.-Nit., and Merc.- Nit., 78. Ranki g, Norw ch: Ac.- Hydr., 78. Ranking, America: Tr. Ferri., P. t. - Chlor., Ac. -Hydr., 79. Perry : Ol. - Tereb., Ammo.-Carb., 79. Ramskill Chloride of Lime, 79. Bleyel Lime-water, 79. Sydenham: Ac. -Sulph., 79. Typhus ani Typhoid springing from bad sewer- age, 27. Uræmic poisoning, mode of death, 38. Water, copious dra ghts of, in Turkish or hot-air bath, 84. Yellow fever springing 'rom banks of Missisippi, 27. LONDON: R. K. BURT AND CO., WINE OFFICE COURT, FLEET STREET. OTHER WORKS BY THE AUTHOR. (C THIRD EDITION, cloth, 1s. Ed.; wrapper, is. THE Philosophy of Homœopathy. (See Opinions of the Press.) Crown 8vo, 200 pp. Price 35. 6d. DIABETES MELLITUS. Its History, Chemistry, Anatomy, Pathology, Phys ology, and Curability by Hydo-Homoeopathy. EXTRACTS FROM REVIEWS. When but a Student of Medicine, the writer was familiar with the name of Dr. W lliam Morgan, whose work on Indigestion,' etc., was a Pioneer Monograph in our school. That book has reached the Sixth Edition, and is deservedly popular. This Monograph is one of a series of valuable brochures which Dr, Morgan has recently written, and should find a place in the library of every physician.' United States Medical Investigator, November, 1877. "This work contains the History, Chemistry, Anatomy, 150 Other Works by the Author. Physiology, Pathology and Treatment of this dread disease, and altogether is to be highly commended."-New England Medical Gazette. "This brochure of 170 pages is a marvel of concentration, and contains more practical matter than is to be found in much larger works. The treatment is sensible and in accordance with so nd pathological views."—Public Opinion. "The man who makes a discovery in medicine that gives him more power over disease is a benefactor to his species; and we have no doubt Dr. Morgan's Ibours will be productive of substantial benefit to many a constitution."-Catholic Times and Opinion, Oct. 18, 1878. : 6th Edition, Crown 8vo, 208 pp. Price 2s. 6d. INDIGESTION, CONSTIPATION, HÆMORRHOIDS, HYPOCHONDRIASIS, FISTULA, PRURITUS ANI, &c. Their Curability by Hydro-Homœopathy. REVIEWS. · } "This is a very sensible and well-written book on an important subject; particularly teresting to those (unfortunately so numerous) who habitually digest with difficulty. A perusal of this work wo d give them some useful insight into the nature of their being, and the conditions under which it may, humanly speaking, be maintained with comfort.”—Bentley's Monthly Review, "We congratulate Dr. Morgan upon the issue of a Sixth Edition of his very useful work. Dr. Morg n's style of writing is always clear and sensible, and thoroughly practical." Homeopathic World. "The Sixth Edition of any work scarcely requires a critical notice, and the fact of a demand for such reissue stamps it with the mark of public approbation."-Monthly Homeopathic Revierv. " We most conscientiously recommend the Sixth Edition of Dr. Morgan's treatise on Stomach Derangements as a first-class work, and in every way worthy of its eminent author."-The London Second Circuit Advocate. 4 Other Works by the Author. 151 Crown 8vo, 264 pp. Price 38. 6d. THE LIVER AND ITS DISEASES, FUNCTIONAL AND ORGANIC. Their History, Anatomy, Pathology, Physiology, and Treatment by Hydro-Homoeopathy. REVIEWS. "This work, which treats on perhaps the most prolific source of human suffering, will prove not a little interesting to the student and practitioner. It is forcibly and earnestly written, and contains a large amount of practical matter."-Brighton Fashionable Visitors' List. "This volume, in a pleasing, chatty style, gives an outline of the functions of the liver, and of the pathology and treatment of those dis- orders in which it is most prone. The book is interesting, and will doubtless be found very useful in directing attention to the class of remedies from which the practitioner has to select when prescrib- ing."-Monthly Homœopathic Review. Now ready, Fcap. 8vo, 160 pp. Price 2s. 6d. PREGNANCY, ITS SIGNS AND CONCOMITANT DERANGEMENTS, With Instructions on the Selection of a Nurse, and the Management of the Lying-in Chamber. REVIEWS. "A thoroughly practical book on a common subject, which gives some plain and sound directions for ladies, that will, we hope, have the effect of sending the 'intolerable monthly nurse' soon to the right-about. A most elaborate table is annexed for the purpose of ու 152 Other Works by the Author. noticing accurately certain necessary calculations."-Public Opinion, July, 1 "This book is dedicated in high-flown language to the Mothers of England. It is associated with Homoeopathic Medication, an ex- cellent system for pregnant women and children."-Chemist and Druggist. Now ready, Crown 8ve, 216 pp. Price 35. 6d. Syphilis and Syphiloidal Diseases. Their History, Anatomy, Physiology, Pathology, and Treatment, "Preventive" and "Curative." WITH COMMENTS ON THE CONTAGIOUS DISEASES ACTS. REVIEWS. "A well-written book on a difficult and delicate subject, in which the author vindicates in a forcible and sound common-sense manner the successful working of the Contagious Diseases Acts. The method of treatment advocated is alike simple and sensible."- Public Opinion, August 25, 1877. LONDON: THE HOMEOPATHIC PUBLISHING COMPANY, 2, FINSBURY CIRCUS, E. C. Homeopathic Publications. 153 NOW READY. NEW AND ENLARGED SERIES, VOL. XIII., 1878, THE HOMEOPATHIC WORLD. A JOURNAL FOR THE EXPOSITION OF THE LAW OF SIMILARS AND ELUCIDATION OF ITS OPERATION. INCLUDING MEDICAL NEWS AND LITERATURE, CASES FROM PRACTICE, SOCIAL AND SANITARY SCIENCE, AND CORRESPONDENCE. Elegantly bound, bevelled boards, gilt lettered, price 7s. 6d. post free. HOMEOPATHIC WORLD VOLUME FOR 1878. SPECIALLY SUITABLE FOR PRESENTATION TO LIBRARIES, READING-ROOMS, &c. Monthly Parts, 6d.; by Post. 7d.; or prepaid, 6s. per annum, post free monthly. An idea of the Contents may be gathered from the Index in the December number. Each volume fur- nishes profitable reading, and will be found very useful for reference. THE YEARLY VOLUMES From 1866 to 1874, inclusive, well bound in cloth, gilt lettered, price 5s. each, post free. Covers for binding, for 1873 and 1874, and previous years, price is. each. Covers for 1875, 1876, 1877, and 1878, Is. 6d. "A welcome addition to ordinary reading."-Public Opinion. "We can recommend this Journal as the best our School ever published."—New England Medical Gazette. 154 Homeopathic Publications. HOMEOPATHIC WORLD. "Fills a void in homeopathic literature. The cheapest jour al published. Filled with well-written articles.”— Boericke and lafel's Quarterly Bulletin. .. Ranks much higher than any other popular homeopathic journal.”—American Homœopathic Observer. "This jurnal has been established twelve years, and has re- ceived contributions from some of the best writers in the School. This, and the two preceding journals, have very faithfully repre- sented the profession in England, and upon the establishment of a School of Homoeopathy in London, as proposed, will have addi- tional opportunities to disseminate the teachings and illustrate the practice of our system of cure."-Ohio Medical and Surgical Reporter, January, 1877. HOMEOPATHIC MISSIONARY TRACTS. I.-Fallacies and Claims. Being a Word to the World on Homœopathy. Fifth Edition.) << "It is the clearest and most comprehensive little treatise we have in our literature."-Dr. Hering Fourth Edition, revised. II.-Ministers and Medicine. An Appeal to Christian Ministers on the subject of Homeopathy. By Rev. THOMAS SIMS, M.A., Author of "Letters on the Sacred Writings," &c. III.- Principles, Practice, and Progress of Homœopathy. (Fourth Edition.) IV.-The Practical Test of Homœopathy; or, Cases of Cure by Homeopathic Remedies, in the Practice of various Physicians. V.-Measles: its Complications and Fatality prevented by Homœopathy. Being contributions from more than twenty medical men. (Second Edition.) VI.-Homœopathy Explained; a Word to the Medical Pro- fession. By Dr. JOHN WILDE. VII.-Constipation: its Origin and Homœopathic Treat- ment; and on the use of Enemata. By Dr. JOHN WIlde. VIII-Scarlet Fever: being an attempt to point out how the ravages of this very fatal disease may be limited. By Dr. JOHN MAFFEY. The above Tracts are published at One Penny each, or for En- closure in Letters, &c., post free, 25 copies for 15 stamps; 50 for 26 stamps; 100 for 48 stamps. List of British and Foreign Homeopathic Medical Books on application. LONDON: HOMEOPATHIC PUBLISHING COMPANY, 2, FINSBURY CIRCUS, E.C. Homeopathic Publications. NOW READY. Seventh edition, 36th Thousand, thoroughly revised and improved, with new Sections, toned paper, handsomely bound in patent morocco, bevelled boards, burnished edges, price 5s. Cheap edition, in cloth, 3s. 6d. THE LADY'S MANUAL OF HOMEOPATHIC 155 TREATMENT IN THE VARIOUS DERANGEMENTS INCIDENT TO HER SEX. BY DR. RUDDOCK. "Written in clear language. Women's diseases are here treated as clearly as the most exacting student could require."— Chemist and Druggist. "The work of Dr. Ruddock is precisely what every woman needs, and contains information for the want of which she often suffers permanent loss of health. The whole range of functions and diseases incident to women is treated with care and precision.”— New England Medical Gazette. "We do not hestitate to say that The Lady's Homeopathic Manual' is the best book of its kind we ever examined. The author knows what to say, how to say it, and how to stop when it is said." United States Medical and Surgical Journal. "The Lady's Manual' is a work that should be in the hands of every lady in the land. The remedies prescribed are mainly homœo- pathic and hydropathic, and are extremely judicious. We never examined a medical work which pleased us so well."-Western Rural. " P The fact that this is the 'Seventh Edition' shows the estimate placed upon it by the public; and the estimate is a just one, for the work is in every respect meritorious. As a book to be placed in the hands of married women it stands unrivalled, and yet it is full of just such information as the general practitioner should possess, and will here find easily and quickly. We have, seen nothing of the kind that pleases us so well.” --Cincinnati Medical Advance. In one handsome volume. Third edition, half-bound, with full Index, price 32s. CLINICAL LECTURES ON THE DISEASES OF WOMEN. BY R. LUDLAM, M.D. "Each_reader will surely find every page filled with carefully reported facts and observations, satisfactory and intelligible to the men who have seen much, and instructive as well as suggestive to all who earnestly desire to see and know more."-American Journal of Homeopathy. 156 Homeopathic Publications. There is a great charm in the author's style and method of elucidating his topics, which involve many moot points in diagnosis and pathology; while the treatment adopted includes the medical, hygienic, dietetic, and mechanical, providing for all the exigencies of each case.”—The Homœopathic World. << THE DISEASES OF INFANTS AND CHILDREN, AND THEIR HOMEOPATHIC AND GENERAL TREATMENT. By E. H. RUDDOCK, M.D., L. R.C.P., M R.C.S., L.M. (Lond. and Edin ), &c. 15th Thousand, 12mo, pp. 228, 35. 6d. "A very valuable contribution to the pathology and therapy of the diseases of children It contains for physicians much interesting matter, and also not a little that is new."-Allgemeine Homep Zeitung. ** Admirable hints on the general management of children, hygienic and medical prescriptions being intended for preventive as well as for curative treatment."-Public Opinion. "The Doctor traverses the entire domain of therapeutics." Daily Review. "Full of familiar notes on disease, and of simple remedies and expedients. Written in a popular and pleasing style, and its arrangement is creditable and convenient. An improvement over other works of its kind in its excellent remarks on the differential diagnosis between diseases which are so rearly alike as not only to puzzle the lay practitioner, but oftentimes the doctor also."-United States Medical and Surgical Journal. "A great accession of practical knowledge relative to the diet and general treatment of the young, which is really available for use."-Ladies' Own Journal and Miscellany "This book is another of the series of pleasing, practical, and valuable domestic treatises which have done so much to spread a knowledge and increase the popularity of homoeopathy in England, and have made Dr. Ruddock famous. "It is a work worthy of commendation; for while written in plain language so that all may understand its teachings, it preserves a sound pathology and diagnosis throughout, and its treatment, which embraces the new remedies 'as well as the old, is in accord with the experience of most practitioners, and is thoroughly safe. < Ci This volume is in keeping with the handsome style in which other volumes by the same prolific author have been presented."- Hahnemannian Monthly. HOMEOPATHIC PUBLISHING COMPANY, 2, FINSBURY CIRCUS, E.C. Filmed by Preservation 1991 ...; : WEL ----- + ➖➖➖➖ mga pa A v 10 kada je A 3 9015 02011 7977 11