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O. H. M. S. 
 
 Depmtf Minitttr. 
 
 LABORATORY 
 
 or THE 
 
 INLAND REVENUE DEPARTMENT 
 
 OTTAWA, CANADA 
 
 BULLETIN No. 181 
 
 \RSENIC, AS AN IMPURITY IN DRUGS. 
 
 3060-1 
 
LABORATORY 
 
 f ■ 
 
 %* 
 
 OF THE 
 
 INLAND REVENUE- DEPARTMENT 
 
 OTTAWA, vjANADA 
 
 BULLETIlSr :No. 183 
 
 AKSKNIC, AS AN IMPURITY IN DRUGS. 
 
 Ottawa, June 8, 1909. 
 
 W. J. Oeuald, E-ii., 
 
 Deputy Minister of Inland Jlevenue. 
 
 Sib —In the year 1900 there occurred in Manchester, England, a large number of 
 cases of' arsenical poisoning. It was discovered that the poison was present in beer 
 which had been made from commercial glucose. Other sources of arsenic in beer were 
 found in malt which had been dried in kilns to which gases from pyntous coal had 
 access. Further research 8howe<i that decided traces of arsenic occurred in many 
 chemical products whose manufacture involved the use of sulphuric acid ; it being 
 already known that crude sulphuric acid (oil of vitrioU is usually contominated with 
 
 For the information of this Department there were examined at that time a number 
 of samples of drugs, as found on the Canadian market, for the purpose of ascertaining 
 whether any of the.-e contained distinct traces of arsenic. While most samples were 
 practically free from the poison, it was found that arsenic was distinctly present in 
 certain sulphates, and particularly in phosphate of soda. The amounts were not so 
 large as to be alarming ; but were sufficient to make it impossible to regard these drugs 
 as meeting pharmacopoeal renuirenients, , , , . , 
 
 The present bulletin contains a report upon 448 samples of aulphatJ of magnesia, 
 sulphate of s.xla and phosphate of soda, three drugs which are as likely as any to contain 
 arsenic as an impurity. It is satisfactory to find that on the total oi 44H samples, 33t 
 
contsin no anenic, 86 contain leas than one-ii^lf of a milligram per hundred grant", 
 twenty leiM than one raillgram and six over one milligrn-n, divided aa follows : — 
 
 
 
 AUkNIC. 
 
 
 
 • 
 
 None. 
 
 t«M than 
 
 onrhaJf 
 
 DiiUigTam 
 
 p«r hundred 
 
 I,eu thar 
 
 one 
 
 inilligram 
 
 per hundred 
 
 grams. 
 
 More than 
 
 one 
 
 milliKram 
 
 per hundred 
 
 grami. 
 
 T.)Ul. 
 
 SulphaUi uf Ma^iwia 
 
 Sulphate of Soda 
 
 130 
 
 09 
 
 117 
 
 30 
 
 36 
 
 * 
 in 
 
 
 6 
 
 
 ISO 
 
 150 
 
 I'hi«i>ti»te of Soda 
 
 25 6 
 
 148 
 
 
 336 
 
 86 30 
 
 K 
 
 448 
 
 The British Pharmacopif ia fixes the dose of Arsenious Acid at j'g to f\ of a grain, 
 corresponding to 001 and 004 milligrams. 
 
 The maximum single dose for eaoh of the three salts mentioned is 14 2 grams and, 
 a$ the largest amount of arsenic found is 10 5 milligrams per one hundred grams, it 
 follows that not more than one and one-half milligram could have been absorbed, which 
 would not bo considered a dangerous dose, four (4) milligrams being allowed. 
 
 I beg to rdcomoiend the publication of this report as Bulletin No. 181. 
 
 I have the honour to be, sir, 
 
 Your obedient servant, 
 
 ALP. LEVIOINE, 
 
 Acting Chie/ Analyst. 
 
 3060— I i 
 

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