CIHM Microfiche Series ({Monographs) ICIMH Collection de microfiches (monographles) Canadian Instituta for Historical Microraproductions / institut Canadian da microraproductions hittoriquas Technical and Bibliographic Notes / Notes techniques et bibliographiques The Institute has attempted to obtain the best original copy available for filming. Features of this copy which may be bibliographically unique, which may alter any of the Images in the reproduction, or which may significantly change the usual method of filming are checKed below. □ Coloured covers / Couverture de couleur n n El n n n Covers damaged / Couverture endommagte Covers restored and/or laminated / Couverture restaur^e et/ou pellicul^e Cover title missing / Le titre de couverture manque Coloured maps / Cartes g^ographiques en couleur Coloured ink (i.e. other than blue or black) / Encre de couleur (i.e. autre que bleue ou noire) Coloured plates and/or illustrations / Planches et/ou illustrations en couleur Bound with other material / Relid avec d'autres documents Only edition available / Seule Edition disponible Tight binding may cause shadows or distortion along interior margin / La reliure serrde peut causer de I'ombre ou de la distorsion le long de la marge int^rieure. Blank leaves added during restorations may appear within the text. Whenever possible, these have been omitted from filming / II se peut que certaines pages blanches ajout^es lors d'une restauration apparaissent dans le texte, mais, lorsque cela ^tait possible, ces pages n'ont pas 6\6 film^es. Additional comments / Commentaires suppl^mentaires: L'Institut a microfilm^ le meilleur exemplaire qu'il lui a 6t6 possible de se procurer. Les details de cet exem- plaire qui sont peut-dtre uniques du point de vue bibll- ographique, qui peuvent modifier une image reproduite. ou qui peuvent exiger une modifk»tion dans la m^tho- de normale de filmage sont indiqu^s ci-dessous. I I Coloured pages / Pages de couleur I I Pages damaged / Pages endommag^s D Pages restored and/or laminated / Pages restaurtes et/ou pellicul^es Pages discoloured, stained or foxed / Pages d^color^es, tachetdes ou piqu^es I I Pages detached / Pages d^tach^es I /[ Showthrough/ Transparence G □ D Quality of print varies / Quality indgale de I'impression Includes supplementary material / Comprend du materiel suppl^mentaire Pages wholly or partially obscured by errata slips, tissues, etc., have been refilmed to ensure the best possible image / Les pages totalement ou partiellement obscurcies par un feuillet d'errata, une pciure, etc., ont ^\6 film^es h nouveau de fa^on d obtenir la meilleure image possible. Opposing pages with varying colouration or discolourations are filmed twice to ensure the best possible image / Les pages s'opposant ayant des colorations variables ou des decolorations sont filmtes deux fois afin d'obtenir la meilleure image possible. Thit Item is filmed at the reduction ratio checlced below / Ce document est film^ au taux de reduction indiqui ci-ti«>«ou8. lOx 14x 18x 22x 26x 30x V 12x 16x 20x 24x 28x 32x The copy filmed h«r« hat b««n raproducad thanki to tha ganarotity of: L'axamplaira filmA fut raproduit grica A la Qtntrot'nt da: National Library of Canada Blblloth^ue natlonale du Canada Tha Imagaa appaaring hara ara tha baat quality poaaibia consldaring tha condition and lagibility of tha original copy and in kaaping with tha filnting contract apacif icationa. Laa imagas tuivantaa ont itt raproduitat avac la plua grand soin. compta tanu da la condition at da la nattat* da I'axamplaira filmi. at an conformity avac laa conditiona du contrat da fiimaga. Original copiaa in printad papar covara ara filmad beginning with tha front covar and anding on tha laat paga with a printad or iiluatratad impraa- aion, or tha back covar whan appropriata. All othar original copiaa ara filmad beginning on tha first page with a printad or iiluatratad impraa- sion. and anding on the last paga with a printad or iiluatratad impraaalon. Laa axamplairaa originaux dont la couvartura an papiar ast ImprimAa sont f!lm4s an commandant par la pramiar plat at an tarminant soit par la darniAra paga qui compona una amprainta d'imprassion ou d'iilustration, soit par la second plat, salon la cas. Toua laa autres exemplaires originaux sont filmis an commen9ant par la pramiire paga qui comporte une empreinte d'Impression ou d'iilustration at 9n tarminant par la derniAre paga qui comporte une telle empreinte. Tha last recorded frame on each microfiche shall contain the symbol •-^ (meening "CON* TINUED"). or the symbol V (meaning "END"), whichever applies. Un det symboles suivants apparaitra sur la derniire image de cheque microfiche, salon le cas: le symboie — *> signifie "A SUIVRE". le symbols V signifie "FIN". Mapa, plates, charts, etc.. may be filmad at different reduction ratios. Those too large to be entirely included in one exposure are filmed beginning in .he upper left hand corner, left to right and top to bottom, as many frames as required. The following diagrama illustrate the method: Les cartes, plenches, tableaux, etc.. peuvent dtre film^s i das taux de reduction diffirents. Lorsque le document ast trop grand pour itre reproduit en un seul cliche, il ast filmA it partir de Tangle supirieur gauche, de gauche A droita. at da haut an bas. an pranant le nombre d'imagas nAcessaira. Las diagrammas suivants illustrant la mithoda. 1 2 3 1 2 3 4 5 6 ■Ji 4-. i J- i X O. H. M. 8. fl Deputy Minittor. LABORATORY or THE INLAND REVENUE DEPARTMENT OTTAWA' A, CANADA BULLETIN No. 146 ID R TJ O S BISMUTH SOBNITRATE, POTASSinM BROMIDE, PHENACETIN 11990—1 i LABORATORY or THE INLAND REVENUE DEPARTMENT OTTAWA, OAXAHA. HULT^KTIlSr No. 140. DRUOS. Bismuth 8ubnit»t« ; PotaMium Bromide ; PheoMetin. OrTAWii, Jftnuwry 25, 1908. W. J. Gerald, Eiq., Deputy Minister of InUnd Rerenue. Sir, — I have the honour to report upon 196 samples of Dtagt, collected in Decem- ber last ; and consisting of the following : — Table I — Bismuth Subnitrate 55 samples. " II— Fotassinm Bromide 67 " " III— Phenacetin 84 " Total 196 Tliese were obtained in each of the (14) inspectoral districts of the Dominion, and doubtless represent, very fairly, the character of the drugs named, as sold throughout Canada. It is very gratifying to know that, in no case has anything which could be properly called adulteration been found. Bitmulh Subnitrat*. (S«e Table I). The percentage of Bismuth has been deter- mined by conversion to the oxide. Tests for Lead, Arsenic and Carbonic Acid have been carefully made. With exception of two samples (Nos. 26355 and 31562), the re- quirements of the British Pharmacopwia were fully met. l^e two samples excepted are Oxy-earbonate of BUmuth, and are manifestly fur- nished as errors in dispensing. These two preparations of Bismuth (Subnitrate and Oxy-carbonate) are so similar in their medicinal value that the error is not a serious one. But such errors should not occur. Potassium Bromide. (See Table II). The British I%»nnacopoeia describes this drug as required to be within one per cent of chemical purity ; and to contain no trace of the heavy metals, or of Cyanides. In all these respects the whole of the 53 samples examined were found to be satisfactory. Phenacetin. (See Table III). Six samples from each inspectoral district were examined as regards specific identity, and abHence of Antifebrin (Acetanilide) and paraphenetidin. All were found to be of requisite purity. The analytical work herein has been done by Mr. liemoine and Mr. Valin of this sUff. I beg to recommend the publication of this report as Bulletin Na 146. I have the honour to be. Sir, Your obedient servant, A. McOILL, Chie/ Analyst. 11990— IJ YABIJe I N'atura lA HMn|J«> 1 •8 Nam* mmI Ar, From 1 lb. ■took b<>ttk> Krum Htock bottle id iton* M If 81-4 None... 80'A ; 81 1 .. .. 80 2 None... M ... II ... Hornt. .jtipniiine. E. Btliind, In$ptetur. 80'4 81 1 80-8 HO'3 Nooe... Nona... •1 ... None. . . aenoliU'. Prment. None. . . t* CO.Apirt'ox.. tFranfftia). (ienuine. .Uopraient 1 J. C. Hoiitrau, Ituptttor. 807 806 80-3 810 NOM... II . . None... II ... II ... None... It ... Genuine. n 1* From I lb. packago. TAHLR Kmiiv III Hmu|iI«>. >IW7. i Namv •imI Arfilrt^ ol V'piiilo. Manufaetum ur Vuraiiher M Rtvra hjr tiw Vmiiot. 6 iOlI IMIrMifM-MlmU-' SlAaiijK. Kthi*r, M.MitrHj .IIIMIJ .liwiili PigHHi, MuiitrHiil . . aiStW A, LetMU, Montrwl S1M7 M. ttilbprt, Ht. .Ivnmiv. ijtic it u !I6 |l4iiiian-KiM>xCu„Muiiti'«al 88 itim known.. , 7A Lynuui, 8»iw A Cij., Mixit- I n»l. :w Lynuui-Knut Cu iHtlriet uf Ottawa- «sc 9 M ». .. 13. .. 17. Biitniiith aubnitratK. 3«7I K. W. Day, (HUwa SMTi WeMon .r. Urahani, (HUwa . . :i«073|c. A. MacHattl.-. ( urnwall . 34074 JohiMton'n I>nig Muw, Arn^ I |iri"r. u lA u 60 u 40 u 76 K. B. Hhiittk-wiirth, CIk-u. Co., Toronto. Burroiiglii., vVclooin ft Co., liondon, Knalami. Lyman, Hona k Co., Mont- rral. Xatiooal Drue Co., Ottawa Dittriet of Kingti.OH— Dec. 3. Binmutli Rulmitratw. . 3iH07;F. C. Clarke, Belleville. 'XUm IX M. W«t«r», Belleville 33499 H. H. Ma<- real. KUllinckrodt. N.Y Lyman and Honit, Mont- real. UaweH, England DitlHcl of Tnronto— Dec. 11. Biamnth aubnitrate. .. la. .. 12. " 17. 33387 W. J. MacVadden. Urillia. . . 33388|D. H. MacLaren. Barrif 8S38B F. (J. Muxlow, Meaford... . 33390 T. Steveaon, OranKevitle u 3.-> li SO 14 30 n 30 i Elliot ft Co. of Nat. Drug Co., Toronto. Nat. Dnijr ft Ch«m. Co., Montreal. Howard ft Sona, E. C Lyinan Broit., Toronto, IHttriel of tomlon— Nov. 29. Bifmuth aubnitrate., Dec. 20. » 24. 30443 ,;ohn Roberto, Seaforth.. 36011IClark Bro«.. ierlin SG012 H. O. Fleming, Windaor. l| 60 l| 20 IJ i !» Elliot ft Co., Toronto. . Howard I: Sjona. . . . Merck, Darmatadt # ^" B^^HwWB^^B* lM|iM«iir'a Rtliort. J. J. OnUtan, i n ir mH r, J. A. Ihtkrf, hipnitr. RMt'kTS or A!>\LT««. ^•. 1 i»pinlua uf thv ChM Analjr*!. hi ■■ m MO'l ,Hem. . . NoB». . . 0»iiniw. Pmrat, Now. CO, A|M'riw.,»|'.e-t»it'»»»'«l»"l'<*"'"*' OcBuinc. MO Num.. NOM... M-JJ H • • . WTi M ... '* T»» ... NoiMi. ...(I^uinc J. Jogan, Jtupeetur. B J. Dafftr, Iniptetor. Skinple taken fium (taok bottiv on iheU. Original wan laMlMl Huward ft Sunf, C. E. SiUDplc taken from atock bottle. 80(» None... None. 80 4 :. I •• ■ 79-8 j ; M . 809 ) ' <> . Ncue. . . (ienuine. 80'4 NoM... NoM... None... UsBuiDe. MO Mfl •1 ... II ... » '. '. ', » ; ' '. ti 81 t) ... H ... M ... " 5. Kidd, Iiupretor. Sampk' taken tiom itock bottle Vendor keep* tianiple in Htook tiottle. Buyi in 1 ox. pkga. None... Oenuine. TABLE i Nature of Sample. i 1 Nanip and Addreas «f Vendor. Coxt. " 3 "3 1 -. 6 cu. Name and AddreM of Manufacturer or Furnisher as given by the Vendor. 1907. o«. Dutriet of Manitoba— l>ec. Kl BimuiUh aubnitrate. " 10. i M 12. M 16 26656 20664 26682 2sea6 U. McCuUoch, Brandon U Kennedy's Pharmacy, Brandon' ij M. Ruckle, Winnipeg j 11 Uunkin's Drug Store, Portage: la Prairie ; u Lyman Broe., Toronto. The Bole Drug Co., Winni- peg, Man. Not given •Tan 8. Bismuth mibnitrate, ■" H.i 28842 Bole Drug Co., Calgary 28843 Oliver Bros., CalgaFy .'. 28844 Curry & Coi*, Calgary, 28846 \V. McLean. HalgiSy. DMriet of Calgary— U 30 jNat Drug Co., Montreal. Ij 30 ' U 30 I 30 Dec. 17. Bismuth subnitrate. " 17.1 " 1" 17 32187 Woods Phannacy, Vancouver. l\ 32188 .1. W. Morrow, Vancouver. ...Ill 32189 Woodward's Dept. Stores, Van-i oouver u 32190 The McDowell, Atkins, Wat- " kins Co I ]i DiUriet of Vancouver— 46 Henderson Bros., Vancou- I ver. .50 W. .J. Bush ftCo., London, Kng. 40 Henderson Broa., Vancou- I ver. 70 I ., Dittruit of ViftoTM— Dec. 12. Bismuth subnitrate..' 34801 1908. ; ■ .Ian. 28. j „ ..i s^gjM 28. 28. .34837 3484U E. Pimbury ft Co., Nanaimo, B.C. D. E. Campbell, Victoria, B.C. Terry & Marett, „ (Jeorge Moran, „ 14 II 35 Lyman Bros., Toronto. Maliinckrodt Chem. Co., N.Y. Nat. Drug Co., Montreal. l—Coneltided. IiMpector*' Re|Mirt. RtHVLTS or ANALYiiia. Opinion of the Chief Analyit. A ■ C. Lariviirt, liuj'frtor. ....! 70-7 1 80-2 None. . . None. . . tt ... None. . ... Genuine. 1 i 80-7 1 80-6 " R. W. flttehtr, Intpfetor. 81 8t-3 None... M ... M None... II ... M ... None.. .| Genuine. 80S 820 'l X. B. Parkhtton, Ituprelor. 80S None. . . None. . . N(ine.. . Genuine. 79-3 80-3 II . . M ... •• 81 8 .. ... « D. 0. Sullivan, Itujieetor. 800 None...] 7»-9 M ... 1 i TB-8 80-4 1 (I ... 1 It . . . ! ! None ... None . . . i Genuine . „ ..., M 11990—2 10 w. 1 « ■s e I .2-* I ' lunjiMniinj 'riinniuiS J9d -.» Ot 1 'OX 8V 1J I S C r •c I. 5i <: -"s u . S = c « = ^ s»0 O S> s = a •»\Aaye^ |0 -oj^ s S 1^ ■no!)Miioo JO avid % I g |8 § S8 ^S s s c 3 '■i''^- u ffi •OlO i -*i Hefcri HW .a X ■ s$ 4 !e jfi s ss s s s s s o eu X 3 3e s 6 JS5 s s^ ij' S5 s r-^w^ E a a ii S s ? il = . I" ©1— Cl S S5i 5! i S I C c a: CiBsJa r S X 0. ;a.t5^J I 11 & ■& is £>- s S 8 S ^H «D e •* 1 Ifc S.S 3 ai jJ tj pa «•>««• i I. lie 9.2-" ►•.'^ e I be ^1 Kj Kd m tn 1— t 2*;:^ -«< » « — ill " III ^ «*5S3 « e s. A. 100 43 100-43 100-67 s 00 O V QO S8 X X 00 xob ob X ta m 3 1 S H "«1 1^ 1 ll 'apituojg «J uininnoj d -AOinnuS jad 'oo i< PI 'ON -uv ^^ b •sis drem Fum Vend ^?l unemnd ufacturei given by !=SS :; , •«10 i I ■X»!ju»n5 i 1 ^i -<| iJ V 1 ii •aidmvg |o -oil 4 ■a 1 •8 § 1 li » •Doitoanoo JO iH»a ^ 1 rH Hi \9 i I I I I I 88S8 ! 1 = J * _&a eoee s s I. . . i^ s ■■'$' n s s a s ea o e « s s 3 s — iijUi Ci C% wa A n 09 n fo r s s Its $ s « s ^ s s s 3 3 I I I S5 S SI s s I i B 3 <£ "8 14 " as < 1 < 6 Hi i '■"Ml' -!i-Y) •»»-'X iioi)«ay!iu.)pi t a. I m "10 •AjlJllKllf) 1"^ 5 'A .il>\mys.. K n n n n n CO •••■^f ^o I > I • t > ! z > z z t >5 5 t z • J « » ^ lO M Mri »l « M «« SO . ,1 li 15 I i B z X t > s L I I s s s s r : t li i il I 11^ ilii 1 I i2 I 3 S . 8 S 8 «- S S e o o e 34 ?-. a. I « x c 1 Sa3 4- • - oasj ISO'S. 4 :s rS p a g ■< ■< w I "8 I I ^5 s • ■ > > I 5 s s s c r >5 J' I X X I t • s ^ I s 'a s mil « I"! K OS 1^ ' ■ u .S £ W M ^ *" flC W 1 k V I e o : ee e i 1 15" '^ ■Ijl i I 1x41 1 •«; Ift-gj d l» g 1 i il f V5 sj S KK K _e z : s s X 1 « *»• ■» •*» O 1 r : XX X 1« 1 « >3 ii < •3 'AUip (opiliatiwv) iMiuq«|!tay no!««>0i)a«p' 1 ill 111 1* : i •«<10 -.(tituanf) ^ r ■•<[ I t t > t ESI I 3 eee so £ S X S I I I I < t I > > .1 8 S 1 S > S >5 f X I s t > <2 1 "pi eees «e Ml m m 1 an 1 = c. o e t-i « «- i- = w if I Hi 1 I 1 O t • S S I » 1 I 1 \il oeooeo .mmmkmmkm Hi I 3'Bddll3aii-» n cocQcQcc n s It ■ • I e ee e oe iJ ^ = = s s^ I I I s hi 1 "& ■ t ■ ■ s s t t t S > t B « SIS t t ilii li II IllL nil f i ri*5 888 a s e' eee e e e li I as e t . » « 18 1 ■?1 ■«aip •tiaaMtitaNj (■^Ijimaey) aaiJqa)|}iiY ill ''la a ! •10 -.<)!iiiimf) I -••lilang fo -.1^ 11 ■vtn\y:n>\\n^\yMtVn\ It 1 i 1 s t ■ I . t t t t r g r I » I ■t S, I t I I 'I ItU u B « P Xa >t' tfc ih i Sft « 8 "a" e ee e s o "'M 1 -HI 9S fflfi *^ ^ ss § »§ ^ § i s c s ] I t t I t t t • I I t J6 ._ ] 1 I ^ k i i did " S h> L3 k- e e e e —e i 6 > > t -■ii> ri a HJ J xj._ 1^ 1-1 = = = =