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Las diagrammas suivants illustrent la mAthoda. errata I to t > pelure, on A D 32X 1 2 3 1 2 3 4 5 6 ■'■f, r %w. -., ,» >^ h ^wwr* >♦•< ^iiyS mm ■'^^ mp M^ ■vM &?^fi 'fm^' m >t^»,^ ^^3*E' ■%hk •4 ij*/i I ;jt^ ^ .,J'4 -^^5 M' ,|iV J^SlS^^f U' ^^ r f* LK' tiv Mi; ..•fet' •3^ s **i ^W*^ u- ^ t» It 1 ' ■-^. -.A&A:.- THE ROYAL JENNERIAN SOCIETY took its rife in January, 1803, in confcqucncc of a Rcqui- fition, fignal by His Royal Highness the Duke of Clarence, feveral of the Nobility, the Lord Mayor, and many other a£live and benevolent Individuals of rank and rcfpe£lability,M'ho convened a Meeting at the London Tavern, where an unanimous fentiment pre- vailed as to the importance of the object : the eftab- liftiment of this ufeful inflitution was refolvc'' upon i a Subfcription was entered into, and an Addrefs to the Public adopted. It has been thought proper to notice thefe cir- cumftances refpeding the origin of the Society, as meriting the particular attention of the chief Magif- trates and principal inhabitants of the feveral Cities and Towns of the United Kingdom, with the earneft hope of inducing them to adopt fimilar meafures within the fphere of their influence j as by fuch cxtenfive co- operation alone will it be poflible to attain that great and dcfirable objei^, the Extermination of the Small-Pox, k\ ft ! I-- Pal Tr Bo; Me Ad Pla Re >• Ml Inl Re Co Ad Lii Fo R( CONTENTS. \ Page Patronage ------------------------ 5 Truftces 8 Board of Dircdors --------------------- 9 Medical Council ---------------------- lo Addrefs iz Plan and Regulations ------------------- a8 Regulations for the Central Houfe -33 ■ Stations -----------------34 — — — Attendance of Stations ----------35 Lift of Stations ------.----------------36 Inftrudlions for Vaccine Inoculation -------------38 Rcgifter of Inoculation ja Comparative View of Natural Small-Pox, Inoculated Small '1 Pox, and Inoculated Cow-Pox ---.3 Addrefs to be prefented at the Baptifm of Children ----- 55 Lift of Subfcribers 56 Form for Legacy -- ..._.----.--. 69 Receivers of Subfcriptions ------------------ ib !l If V i ( s ) t^troti— ti^ Mm* l&atrone©— tfte j©ueem His Royal Highnefs the Prince of Wales. His Royal Highnefs the Duke of York. His Royal Highnefs the Duke of Clarence. His Royal Highnefs the Duke of Cumberland. His Royal Highnefs the Duke of Cambridge. His Royal Highnefs the Duke of Glouceder. !^tce#attonef^e)^. Her Royal Highnefs the Princefs of Wales. Her Royal Highnefs the Duchefs of York. Her Royal Highnefs the Princefs Sophia Augufla. Her Royal Highnefs the Princefs Elizabeth. Her Royal Highnefs the Princefs Mary. Her Royal Highnefs the Princefs Sophia. Her Royal Highnefs the Princefs Amelia. A3 ( 6 ) ftefitient, His Grace the Duke of Bedford. ;§uft#atroncf!iie!*. Duchefs of Devonfliire. Rt. Hon. Lady Hervey. '' j Duchefs of Marlborough. Vifcountefs St. Afaph. | Duchefs of Rutland, Lady Theodofia Maria Viner. 1 Dfs. of Northumberland. Lady Willoughby dcErefty. Marchionefs of Bath. Lady Hobart. Marchionefs of Hertford. Lady Sherborne. Marchionefs of Bute. Lady Rous. Marchionefs of Sligo. Lady Louifa Brome. Countefs of Carlifle. Lady Mary Stopford. | Countefs of Sutherland. Lady Sheffield. | Countefs of Dartmouth. Lady Templeton^ 1 Countefs Fitzwilliam. Lady Huntingfield. Countefs Spencer. Lady Frances Moreton. Countefs Bathurll, Lady Caroline Wrottefley Countefs of Uxbridge. Hon, Mrs. Harcourt. Countefs Grofvenor. Hon. Mrs. Spencer Perceval. Countefs Camden. Lady Richard Carr GlyOt Countefs of Carnarvon, Lady Nepean. Countefs of Darnley. Mrs. Beaumont. Vifcountefs Lowther. Mrs. Boucherett, ' Rt, Hon. Lady Garlics. j Mrs. BurdoQ. i ( 7 ) Mrs.ChapUn of Blanckney. Mrs. Manning. Mrs. Chute. Mrs. Neave. Mrs. Charles Grant. Mrs. Henry Hicks. Mrs. Thomas Kingfcote. Mrs. Beeflon Long. Mrs. Thelluflbn. Mrs. Charles Wall. Mifs Anger (lein. : i,il if 3^icp^tt^itimt^* it'MI , . Archbifhop of Canterbury. Lord Chancellor. Duke of Somerfet. Duke of Devonfliire, Duke of Northumberland. Marquis of Hertford Marquis of Worcefter. Earl of Shrewfljury. Earl of Derby. Earl of Weltmoreland. Earl of Berkeley. Earl of Egrcmont. EarlofHarcourt. Earl of Hardwicke. Earl Spencer. Earl of Liverpool. Earl St. Vincent. Earl of Da'-nley. Earl of Limerick. Earl Moira. Lord Vifcount Melville. Bifhop of London. Bifliop of Durham. LordVifcount CafUereagb- Lord Pelham. Lord Somerville. Lord Rous. Lord Carrington. Lord Gwydir. Lord Auckland. t Lord Hobart. Lord Gardner. Rt. Hon. Charles Abbot Speaker of the Houfe of Commons. ) 1 U it. '% Y-- i. ( 8 ) ?u II Rt. Hon. Charles Price Lord Mayor M. P. Rt. Hon. Henry Adding- ton M. P. Edward Jenncr M.D. John Julius Angerftein Efq. Thomas Bernard Efq. Thomfon Bonar Efq. Rt. Hon. Wm. Pitt M.P. Harvey Chriftian Combe R t. Hon. Sir Jofeph Banks Efq. M.P. Ba. t. K. B. John Fuller Efq. M.P. Hon. Adml. Berkeley Abraham Goldfmid Efq. M. P. George Hibbert Efq. Hon.Charles J. Fox M.P. W. S. Poyntz Efq. M.P. Hon. Charles Grey M.P. R. B. Sheridan Efq. M.P. Wra. Smith Efq. M.P. HenryThornton Efq. M.P. George Tierney Efq. M.P. Benjamin Travers Efq. Saml.Whitbread Efq. M.P. W. Wiiberforce, Efq. Sir Henry Mildmay Bart. M. P. Sir Francis Baring Bart. M.P. Sir John Wm. Anderfon Bart. M. P. Sir Wm. Curtis Bart. M.P. M.P. The Right Honorable Charles Price M. P. Lord Mayor. John Julius Angerftein Efq. Benjamin Travers Efq. Vi ' f .51 ( 9 ) SSoatbof^irectori^. Gideon Acland Efq. William Allen Efq. Robert Barclay Efq. Thomas Baring Efq. Thomas Bodley Efq. Timothy Brown Efq. John Buxton Efq. Allen Chatfield Efq. John Chriftie Efq. Thomas Cobb Efq. William Dyne Efq. George Eade Efq. Thos. Everett Efq. M.P. John Fenn Efq. Nathaniel Fenn Efq Ebenezer Johnflon Efq. Robert Ladbroke Efq. Felix Ladbroke Efq» Jofeph Leaper Efq. SirWm.LelghtJtfiAld. £. L^^^ckmu^ Efq. ^asJWaWly Efq. lliajlr Minfer Efq. jihi>4^^1ftls Efq. J^hnJBowyer Nichols Efq. Mrd Phillips Efq. illiam Phillips Efq. lexander Rofs Efq. n Towill Rutt Efq. Samuel Thorp Efq. Thomas Fenn \m. Efq.r^john Townfend Efq. Edward FletcftcriEf'r P I r "A I'-l ADDRESS. I A HE fubje£l for which we now claim the public attention is a difcovery of no common importance, which greatly involves the fafety and happinefs of mankind, and comes home to the feelings of every family, and of every bofom : a difcovery which in its confequcnces will not be of partial or local operation, but is equally interefling to every rank, clafs and ftation in fuciety : nor are its benefhs confined to a fmgle country, or a fmgle age; they extend to the whole world, and to the remoteft pofterity. Our familiarity with any difeafe is too apt to ren- der us indifferent to its efFe£ls, when not immediately connected with our perfonal feelings, and to lead us to confider its ravages as refulting from the eftablifhed courfe and order of nature. It is the province of reafon to correal thefe prejudices; to roufe us from this fupinenefs ; and when a difcovery is made, un- equalled in the hiftory of the healing art, which af- I m 1 ill ? ' 1 ^ ( u ) fords an antidote to one of the mofV fatal and diftref- fing of all difeafes, it would be the higheil ingratitude to the Author of our being to rcjefk the boon fo pro- videntially offered, fo that it becomes the duty, as wcU as intcrcll, of every individual to ufe his beft exertions in promoting its adoption and cnfuring its fuccefs. We therefore exhort every man who has any juft regard for himfclf, for his family, for his friends, or for his country, to examine and to decide. Many centuries have now elapfed fince the Small- Pox began its de(lru£bive career, and fo widely has this calamity been extended, that fcarcely a fpot on the habitable globe has efcaped its ravages. In fome parts of the world it has appeared only at uncertain intervals, fpreading its defolating contagion with fuch rapidity as to exterminate v. iiole tribes of people: in other countries it has taken permanent root, and by becoming as it were domeflicated, has purfued a more moderate c ourfe of de(liu£lion ; but ftill, even in this ifland, and in the other civilized parts of Europe, it is adually fatal to at leafl one twelfth part of the human fpecies. Small-pox, when receded by contagiou. cfl^uvia, (or in the natural ivay as it is termed) isj • i ; .2.^'^'i proportion of cafes, a fevere and deplorable malady, fh Peking and loathfome to the fenfes, and to the fufFerer I ( <5 ) peculiarly painful nnd dilbclTmg. It Is almoft equally deftru£livc to all rank, nd clall^ii of Ibclctvi nor is the rifle to life the only caul, for dreading its attack; fince, even when not fatal, it often leaves indelible fears, often produces weakncfs of fight, and even in- «:urable blindncfs,* and tends, in a peculiar degree, to excite fcrophula and other difeafes. To mitigate the feverity of Small-pox, the practice of inoculation was introduced into England about eighty years ago, and has fpread at different periods, (though flowly and partially) into the mofl: civilized parts of Europe. Many were the difEcultics n had to encounter from prejudice, ignorance, and timidity, and from the unflcilfulnefs of its earlieft pron oters; but experience has fo fully eflablifhed its char. !■ u .^f i nV ; i ( i6 ) eafc, has been fuch as to reduce the number of fatal cafes from one out of fix infcfted perfons (the ave- rage proportion of death by the natural Small-pox) to about one in three hundred, ftill this degree of rifle muft give fome alarm to the anxious parent, when the life of a beloved child ir. at (lake; nor has inocu- lation been able in all cafes to prevent the unfightly fears and deformities, and the fubfequent injury to general health, which are the lamentable confequences of a fevere form of this difeafe. But the pofitive evil produced by the partial adoption of Small-pox inocu- lation has been a more extcnfive propagation of the diforder in the natural way; for though this conta- gion might perhaps have been exterminated by a vi- gorous fyftem of univerfal inoculation carried on at the fame time in every part of the kingdom, yet as this plan was never purfued, the neceflary confequence has been, that whilfl individuals have been receiving the infection by the mild method of inoculation, they have been uniformly fpreading it abroad under the terrible form of general contagion. Before inocula- tion was introduced, many remote and little fre- quented fituations might be found, where the in- habitants had efcaped the Small-pox during the courfc of a long life : but fince this practice has been ex- ,■ '■ t X ( '7 ) tended widely, and without precaution (the inter- courfe between diftant parts of the kingdom having at the fame time become more frequent), fcarcely a village or hamlet in the molt retired corner of the iiland can be pointed out, which has not been re- peatedly vifited by this contagion. Inoculation, there- fore, has been faving with one hand, and deftroying with the other J and authentic documents prove an adlual increafe of late years in the mortality of Small- pox of about feventeen in every thoufand. On a fair unexaggerated ftatement, three thoufand lives in London and its immediate vicinity, and forty thou- fand in tlie United Kingdom are annually the diredt vi(SlIms of the Small-pox, befides a great mortality occafioned by diforders confequent upon this difeafe. Other countries fuffer ftill more from this calamity than our own ; and it is important to remark, that this facri- fice of life occurs for the moft part at an early period, to thofe who might otherwife have become ufeful and valuable members of fociety. All the difadvantages under which the inoculation of Small-pox has hitherto laboured, all the rifk to life and general health which has attended its ufe, and all the hazard of fpreading a moft dangerous contagion, are now however completely removed by the invalu- B \l v.. w \\ I 1 »... It h ff.R Ml ( i8 ) able difcovery of our countryman Dr. Jenner. A difeafe hasj from time immemorial, been known in certain f)arts of the kingdom to exift in the Cow, to be communicated from this animal to the hands of milkers, and to fecure perfons, thus infe£led, from ever after receiving the contagion of Small-pox. This difeafe Dr. Jenner has moll happily applied to the purpofe of inoculation; and the ineftimable advantages, which it is found to pofiefs, are fo fully eftablifhed by many thoufand experiments, as to enable us to aflert, with- out fear of contradidlion, that by this eafy, fafe, and effedual procefs, the Small-pox may be fpeedily exter- minated from this kingdom, and ultimately from the whole earth. The following arc the peculiar advantages of the new inoculation: It is never contagious by effluvia, or by any other known mode of infection, except by adlual conta£l: or infertion of matter ; and this fingle circumflance gives it the moft decided fuperiority over the common inoculation, fmce it obviates the moft. important objedion urged againll this pradlice on the ground of its i'preading a dangerous and highly con- tagious difeafe. Even in other refpeds it is prefer- able to Small-pox inoculation, for while it gives as perfe^ a fecurity from all future contagion, it affords ( 19 ) this Invaluable benefit on much eafier terms; The inoculated Small-pox, though mild in moil inftances, is fometimes fevere, and occafionally fatal : the inocu- lated Cow-pox, on the contrary, is almoft invariably mild, requires no confinement, and feldom any medical treatment, produces no eruption beyond the part ino- culated, leaves no injury to the general health, and, if we may form any conclufion from the extenfive expe- rience of Dr. Jenneb, and other medical praftitioners, will, when properly conduded, never endanger life. The intereft excited by this difcovery has been, in fome degree, though not entirely, proportionate to its high importance. The new inoculation has been extenfively patronifed in this its parent country by a large body of enlightened and liberal men, and by numerous public inflitutions, whilil many foreign. nations, with a deference to this country, highly flat- tering to its exalted reputation for good fenfe and liberal enquiry, have already adopted, and are rapidly extending it to every quarter of the globe. Above all, the Britiih Parliament, after a long and accurate inveftigation of its merits, has given it the fan£lion of public approbation, by bellowing a reward on the difcoverer of this invaluable blefling. ! m M I I :♦ j » i ^i ( 20 ) ft muft be admitted that the new inoculation has met with fome oppofition, and objeftions have been urged, which it would be uncandid to pafs over in filence. Some of thefe objedions, and certainly the mofl weighty, relate to matter of fa£t and actual obfervation ; others have a more vague and uncertain bafis. It is unqueflioned, that fome cafes have occur- red, in which a fuppofed inoculation of Cow-pox has failed to produce the promifed fecurity : other cafes have been met with, in which the fymptoms of the difeafe induced by inoculation are ftated to have been fo fevere, and even fatal, as to perplex and aftonifti thofe who had been accuftomed to view in the new praftlce nothing but an uniformly mild, fafe and cfFe£luaI preventive of a moft formidable contagion. In anfwer to thofe obje£^ions, it might be urged, that were all the alleged in fiances of ill fuccefi acknow- ledged to be true in their fulleft extent, and the mild- nefs of Cow-pox allowed to be only proportional, ftill this proportion, compared with the moft favourable inoculation of Small-pox, would give the new practice a moft decided claim to tlie preference of individuals, whilft Its uncontagious njture (which is not difputed) would equally recommend it to public approbation. But it would be higlily unjuft to the merits of Cow- m u r> » ;■ ( 21 T pox inoculation to make this conceflion. The a£Hon of Cow-pox does not prevent the conftitution from being at the fame time attacked by infantile and other prevalent difeafes, fo that the few cafes of fatal termi- nation imputed to this fource may fairly be afcribed to the concurrent operation of fome mortal difordcr wholly unconnected with the new inoculation. It is the more candid to allow of this explanation, fince by fiir the greater number of the fuppofed failures have been aSiually traced to fome palpable mifreprefentatiou ©f fa£ls,* or have been moll fatisfadorily accounted for, from the want of experience in the infancy of the practice, to afcertain the characteriftic marks of the true difeafe. To conduCl with fafety and propriety this inoculation, fimple as it is, an accurate knowledge of Its genuine appearances, and of the fpurious varieties which fometimes intrude, is indifpenfably neceflary ; its fimplicity has introduced fome degree of careleflhefs in attending to its real charadler ; fome precautions, not at firft noticed, are now found to be requifitci * Two cafes of death by the Cow-pox having been publifhed in the London bills of mortality, a committee of the Jennerian Society was appointed to inveftigate their particulars. — The committee have reported, on the moft authentic and fatislavjlory documents, that there was not the flighteft foundation for attributing thefe iu- ftanccs of fatality either immediately or remotely to the Cow-pox. One of the children died of fcarlet fever twelve months after it had pafled through the vaccine difeafe. — The other, of convu'.fions from teething fourteen weeks afterwards.— In both, the inoculation was attended by none but the moll favourable circumftanccs, The errors arofc with the Searchers. I li] IP If li m i ' 1 1 . I h. ( 22 ) for, as the iuccefs of all medical pra£l:ice has expe- rience for its bafis, it would have been wonderful indeed, and next to miraculous, if every circumftancc relating to the new inoculation had been at once fuggefted to the minds of its earlieft promoters by intuitive perception. Certain opponents of the new practice have fprcad an alarm of fome terrible calamity, fome myfterious change in the very nature and propenfities of the human race, to be apprehended from the introduction of a difeafe originating in a brute animal. To fuch an objedlion as this, which has never been fairly brought forward, and is even now almofl entirely abandoned, what more need we fay in reply, than that it is a mere creature of the imagination, not only unfupported by a fingle fa£l-, or probable analogy, but aCtually deftroyed by the experience of time immemorial, in the countries in which Cow-pox was firft difcovered ^ Since then the infe£lion derived immediately from the animal is found entirely free from thefe obje£lions, and fmce fucceflive inoculations from one human fubje£l to another have hitherto produced no other cfFe£l:, than to mitigate all the fymptoms that attend the original difeafe, what is there of prefumption or rafhnefs in endeavouring to root out fi;om the human yace a prefent evil of gigantic magnUude, by the fub- ( 23 ) ftitution of a mild and benign diforder, derived from an animal fo long devoted to the fervice of mankind ? Still, however, there are fome who without openly controverting the fuperiority of this '•ew difcovery, rejea it in praaice, Hmply becaufe the Small-pox inoculation has fuccceded with themfelves and their families to the utmoft of their wifhes. But will not the feeling and confcientious parent experience fome uueafmefs in refleding, that whilit his own child i.s receiving the antidote^ it is at the fame time fpreading the poifofty and bringing into imminent danger the children and families of thqfe, who have not thought proper, or found it convenient to refort to tlie fecurity afforded by inoculation. On this very account. Small- pox inoculation, in feveral well regulated countries, has been prohibite4 under heavy penalties, or pradlife^i under fevere reftri£l:ions. So rapidly is the new inoculation fpreading through- out the kingdom, and fo ardently is it now patronifed i)y private and public favour, that we cannot but entertain the hope, that the inhabitants of this country will now eagerly unite in the great undertaking of extending it over every part of the Britifli empire. The time la arrived when all that was rcquifite for experiment has been more than amply fulfilled, and a farther delay in the 2'^- Turner Mr. Brown. Mecting-houfe. r ' I ( 58 ) 1 I'i^' INSTRUCTIONS FOR VACCINE INOCULATION. Ul H ^:i;i AN ACCURATE KNOWLEDGE OF THE SIGNS OF INF£C- TION, AND OF THE CHARACTER AND PROGRESS OF THE VACCINE VESICLE, IS ESSENTIAL TO THE SUCCESS OF THIS INOCULATION. ';il ^he Signs of Infection, and Defer iption of the Vaccine Veficle, WHEN Vaccine Inoculation proves fuccefsfuJ. a fmall red fpot, with a degree of elevation which may be felt, commonly commences on the third day. When examined with a magnifying glafs, it feems to confift of a fmall tumour, furrounded by a flight efflorefcence. Between the third and fixth day, a veficle appears} the fhape and magnitude of which depend much on the mode in which the inoculation has been performed : when it is performed by a flight puncture, the vei^lc will be fmall and circular. ^i \- m ( 39 ) The edge of the Vaccine Veficle Is elevated and well defined ; the centre is depr'^ffed, and a fpeck is rherc vifiblc, of a darker colour than the reft of the furface. This vcficle is diftinguiflied from other veficles by the peculiarity of its ftrudure, which is cellular, and fomewhat hard and firm. At firft it is of a light pink colour, fometimes blended with a bluifh tint, gradually changing in its progrefs into a pearl colour. Its con- tents are limpid, and almoft colourlefs. It commonly increafes in fize till about the tenth day. In its early ftages it has ufually a fmall inflamed ring round its bafe, which about the ninth day begins to fpread rapidly, and about the tenth forms an Areola, more or lefs circular, an inch and half or more in dia- meter. This areola is of a pink, fcarlet, or crimfon hue ; and is attended with fome degree of hardnefs and tumefa^lion. It continues nearly ftationary a day or two, and then begins to fade ; fometimes forming on its decline, two or three concentric circles. When the areola is perfectly formed, the veficle begins to decline : firft it turns brown in the centre j then it is gradually converted into a hard, fmooth, (hining fcab, of a dark mahogany brown colour, ap- proaching to black; and, in its general appearance, has not unaptly been compared to the fedlion of a tamarind ftone. This fcab commonly falls off about the end of the third week ; and leaves a circumi'cribcd M Tti jLI J k s\ M'i ( 40 ) M t, I. ! li I ' lii ' ■ (., ! I* " '■' I;'. 1' cioatrix, cl«ar}y denoting, that the true ikia has been affeaed. In the computation of time the day of inoculation is to be confidered ^s the firft day. Occajional Deviations of the Vaccine VeJielCy from its ordinary appearance* and cbaraQer, Deviations arc occafionally met with, even in the genuine vaccine veficle; chiefly with regard to its rife, duration, and contents. It feldom or never appears earlier, but often later than the period already mentioned} fometimes not till after the expiration of a fortnight or three weeks } but if it then makes a regular progrcfs, it renders the patient equally fecure, as if it had appeared at the ufual time. Sometimes the veficle is ruptured by external vio- lence. In that cafe, the fcab will in general be lefs firm, and of a lighter colour. Occafionally alfo, inftead of the regular progrefs to deficc^cion, as above de« fcribed, it pafles into a flate of ulceration, with a much more extended inflammation. The contained fluid inflead of being limpid as ufual, is now and then found opake. ( 41 ) '<1 Spurious Pustules^ which afford nofecurtty agait$Ji $bt Small' f*»tt. The fuccefs of the operation Is doubtful} when there is any confiderable deviation from the ufual courfe of the difeafe ; whether premature inflamma- tion, irritation, itching, or vefication occurs ; or the progrefs of the veficle is too rapid, its contents yellow or opake, its texture foft, its centre elevated, or its form not well defined ; or whether a premature efflo- refcence takes place, and a diftinftj vivid^ circum- fcribed areola is wanting. This anomalous veficle, or fpurious puftule, as it is cali'^d, is more liable to be broken than the regular genuine veficle, from its centre being more elevated, and its texture lefs firm. When broken, it is fre- 4|uentiy fucceeded by ulceration ^ or by a light browny «F an»ber-co)pured creeping fcib. 4".i :fi 42 ) ■' if •■:|l Probable Caufes of Spurious Pujlule/, h m ' :ii:ip ' Spurious puftulcs may be occafioned not only by matter taken from a fpurious puftulc, but alfo by mat- ter taken from a genuine veficle at too late a period ; or by that which has been injured by keeping, expofurc to heat, or any other caufe. They may alfo be occa- fioned by ufing rufty lancets in inoculating ; — by rude and unflcilful methods of performing the inoculation; or by the genuine veficle having been dcftroyed at an early flage ; and the regular progrefs of the difcafc thus interrupted. if i n 4 i| ! i J :!■ fUf^l ] T/jc Methods of taking Vaccine Matter for Inc/cu/alioitf and of prcfervlng and conveying it. Matter may be taken frmn a genuine veficle at any time, from its commencement till the areola begins to fpread j commonly till the eighth or ninth day, fometimes later, but never after the areola is fully formed It is to be taken by fmall fuperficial pundures, made in fercral parts of the veficle with the point of a lancet introduced horizontally. Time fhould be allowed for the fluid to exude, which will appear on { 43 ) the veficle In the form of fmall pellucid drops. If neccfTary, very flight preflure may be applied with the flat furface of the lancet, to quicken the difchargc. Great caution mud be obferved in this procefs i or violent inflammation, and extenfivc ulceration may fometlmcs enfue. The matter may be received on the points of com- mon lancets, when It is defigned for ufc immediately, or within a very few daysj otherwife thefe inftruments cannot with propriety be employed either for the prc- fervation or conveyance of vaccine matter, as when charged with that fluid they foon rufl:. An ivory lancet is not liable to this objeftion. It may be fixed in a handle, and fcrewed into a cafe, in order to exclude air. A common method Is, to take two fmall fquare pieces of glafs, on the centre of one of which the matter may b«' received, by applying the glafs to the veficle, pun«3:ured in feveral places in the manner before defcribcd, and covered v/ith the fluid : it may then be fuflPered to dry, and applied to the veficle repeatedly. When fully charged, and dry, it is to be covered with the correfponding piece of glafs, and wrapped up in writing paper, or goldbeater's flcin. Matter may alfo be taken on thread, which, being imbued with it, muft be fufFered to dry, and then ;) :'i i ',■ l.k \ I ' ! ( 44 ) charged ag^n : this procefs may be repeated till it is urell fatiirated : it may be kept in a phial, or in a quill^ or a piece of a tobacco-pipe, flopped with white wax: — ^the heat neceflary to melt fcaling-wax might mjure the matter. Another way of preferving matter is to take it on the end of a quill, which, when dry, may be inferted into the barrel of another quill : or if flender portions of a quill be pointed like tooth-picks, a number of them^ when charged, may be inclofed in the barrel of one quill. Thefe, as well as the thread, afford conve- nient modes of conveying the matter in a letter to any diflant place. A fmall inftrumcnt made of ivory, fhaped like the tooth of a comb, and pointed like a lancet, which may be called a Vaccinator, is in every refpeft zs well adapted to the fame purpofe } and not being liable to bend, it is introduced into the pundlure with more cafe and certainty than the tooth-pick. Thefe inftru- ments require much lefs matter to charge them than thread or glafs^ but when they are not intended to be ufed foon, they ought to be repeatedly charged.— When they are to be ufed in a ihort time, it is fuffi- cient to wrap them in paper. Matter mufl always be allowed to dry without heat m the (hade,, and be kept in a dry and cool place. ( 45 ) Efcry praf^ltioner who has not a conftant fucceffion of patients, ought to take matter when he has an op- portunity, and to preferve it for any future occaCon. The Modes of Ineculathn, The conftltutional, as well as the local fymptoms of the Vaccine AfFeftion, depend in a great degree on the mode in which the virus is inferted. The fmaller the wound of the (kin is, the lighter in general is the difeafe. Fluid matter is better than dry, when it can be procured, becaufe it is more likely to produce infec- tion J and the operation is more lightly and quickly performed. Hence it is evident, that in every inftance where it is practicable, the patient from whom the matter is to be taken fhould be prefent, and the matter Ihould be transferred immediately from arm to arm. Inoculation is generally performed in the upper arm, near the infertion of the deltoid mufcle ; but in fome adults, who are likely to ufe the arm much, it is more advifeable to inoculate on the infide of the leg, a little below the knee. The point of a lancet being charged, the fkin (hould be ftretched, that the cuticle may be penetrated with >i &: i ■'.ii V 1 iiij i ( 4^ ) more eafe. A fmall fuperHcIal pun£ture is then to be made with the point of the lancet, which will be more likely to leave the matter in contad with the flcin, and to produce the defired efFe£V, if it be held nearly in a horizontal dire£lion. It is aifo worthy of remark, that when held in this dire£tion, the lancet meets with greater obftruflion when it has penetrated to a fufficient depth. On the contrary, when it is inferted in a more oblique or a perpendicular direc- tion, it often penetrates fuddenly to fuch a depth as to caufe an efFufion of blood, which wafties away the matter, and prevents the operation from fucceeding. In order to render infe£tion more certain, the point of the lancet may be charged with matter a fecond time^ and wiped on the pundlure. WTien feveral fucceflive inoculations are to he performed, the lancet ihould be dipped in cold water, and wiped after every pun£ture. Dry matter lias been fometimes known to fucceed after tlie expiration of feveral months, but that which is recent is always preferable. Dry matter on glafs may be moiftened with a little cold or tepid water on the point of a lancet, allowing it fome time to diflblve, and blending it by a little frl(^iou with the lancet. It mud not be much diluted. t1 ( 47 ) but of a thick confiftence. It is to be Inferted in the fame manner as the recent fluid. Dry matter on the barrel of a quill may be applied without dilution, to a very fmall abrafion or incifion of the (kin; and, being held in contaft for fome time, and then repeatedly drawn over the part, it will dif- folve and be lodged in the wound. When ivory lancets, toothpicks, and vaccinators, charged with dry matter, are ufed, the matter (hould not be firft diluted, but a pun6ture having been firll made with a common lancet, the point of the inftru- ment is to be inferted, and held in the pundure half 3 minute or more ; when the matter will gradually oiA olve, and remain in the part. If the part of tlie Inftrumcnt which is charged, be afterwards wiped repeatedly upon the edges of the puniSlure, it will tend to enfure fuccefs. Thread, charged with dry matter, may be ufed cither dry or jull moiftened with cold or tepid water. A flight incifion or abrafion is then to be made, not more than an eighth part of an inch in length, on which a fmall portion of the thread is to be placed. This is to be covered with a fmall bit of paper, and to be retained two or three days by a mild adhefive plaifter : what is called court plaifter is liable to pro- duce irritation. A' v\ >f« 4 ( 48 ) Inoculated patients mufl: be cautioned not to wear tight fleeves, and not to injure the arm by prefluirey fri&lMiy or any other violence, left extenfive inHam^ n: lOn or ulceration ihould enfue. One vaccine veficle fecures the patient from all danger of tlie irnall'opox ; but in many inftances it is better to inoculate in both arms, efpecially when the fmalKpox is epidemic, or the matter is dry, or the place of the patient^ refidence diftant. Lancets ufed for inoculation ihould be kept clean and bright. Constitutional Symptoms, '[I' fffi ill m \ \ ) ' t-. The conftitutional fymptoms fometimcs occur at a very early period ; but more commonly from the feventh to the eleventh day. In fome cafes the patient is drowfy ; in others reft- lefs. Sometimes there is a chillinefs, fuccecdcd by heat, thirft, head-ach, and other marks of febrile afFe£lion. Now and then a ficknefs or vomiting takes place, efpecially in infants. The conftitutional fymptoms, of whatever kind, arc in general flight and tranfient, and fuch as require no remedy. ( 49 ) In a great proportion of cafes there Is no percepti- ble indifpolition ; neverthelefs, the perfon vaccinated is not the lefs fecure from the future infedion of tlie Small-pox, provided the progrefs of the veficle has been regular and complete. Care mull be taken not to confound the fymptoms of infantile or other difeafes with thofe of vaccine inoculation. dean Medical Treatment. In general no medicine :s required In this mild affe£tion ; but if the fymptoms happen to run a little more high than ufual, the fame remedies are to be applied, as if they proceeded from any other caufe. No preparation is neceflary; and no cathartics need be given either before or after vaccination. Should inflammation of the arm exceed the ufual bounds, which rarely happens but from tight lleeves, pieflure, or fri£tion, it may foon bo checked by the very frequent application of comprefles of linen dinped in water, aqua lithargyri acctati "ompofita, or a folu- tion of one drachm of ccruflli acetata in a pint of v/ater. Thefe arc to be applied cold. If the fcab be rubbed ofl' prematurely, and ulcera- tion take place, coolipg and ailiingent applications ( so ) H . «f 'i1 '■ i I may be ufed, fuch as a drop of aqua lithargyri acetatiy which (hould be allowed to dry on the part, and then be covered with comprefles, dipped in water, or ?n f the faturnine applications above mentioned, and frt>/:iencly renewed. When the ulceration is deep or extenfive, a poultice^ cither of bread and milk, or of bread with any of the faturnine preparations may be applied, as the cafe feems to require. They muft never be applied till they 9''e nearly, or quite cold. In fuch foul and obflinate fores, as refift the fore^ going applications, the unguentum hydrargyri nitrati ; the argentum nitratum, or other fimilar applications, are fometimes reforted to with advan«-age. A fmgle drefTmg with thefe fubilances is ufually fufficient ; after which the fore heals under the mildefl; applica- tions. Spurious puftules arc frequently followed by ulce- ration at an early period. This ulceration is to be treated in the fame manner as if it proceeded from the genuine fpecies. An aflurance of perfect fecurity from vaccine ino- culation can only be obtained by carefully obferving the whole progrefs of the difeafe. If any doubt re- main, the operation ought to be repeated. fl icetatiy id then ter, or ed, and oulticCy r of the lie cafe lied till he fore-' nitrati ; ications, A fingle fficient ; applica^ by ulce- is to be ed from :inc ino- )bferving ioubt re- ( s> ) When the patient has been previoufly expofed to the infedlion of the Small-pox, that difeafe will be fuperfeded more or Icfs, according to the time which is fufFered to elapfe before the inoculation of the Cow-pock. The advantages of vaccine inoculation being now fully aicertained, it is the duty of every member of fociety, and particularly of every member of the medical profeflion, to difcourage the inoculation of the Small-pox. As it is deemed highly proper and advantageous, that particular and exa£l: Regifters of the vaccine practice fhould be kept by every inoculator, the forms of the Regifters, employed by the Royal Jcpnerian Society in their central houfe, and the feveral inocu- lating ftatlons, are annexed. — A feparate book *. alfo kept for detailed accounts of any remarkable cafes, which may require to be more fully recorded than the plan of an ordinary regifter may admit of. Copies likcwife are here given of fuch papers as have hitherto been printed, both for the ufe of the patients, and for more general diftribution, for pro- moting the views of the Society amongft all clafles of the community. D % i % ! M i 1 WiH : irl ' I; ( 5» ) Cdr // " pmumed, by the Society, that the Community would derive considerable advantage by their receiving from ther Vaccine Societies, an jinnual Return of the Number of Patients inocuhted; which should be sent to the Central House, No. 14, Salisbury Square, before the \Jl fVednesday in March f in each Tear, CCj* Communications of real importance, relating to the Vaccine PraSice, will meet with ready attention by the Medical Council of the Royal Jennerian Society.— "-"It is rejuefted that they be drawn up concisely, and tvell authenti- eated. t :)ii Community iving from Number of \tral House, ir in March, uittg to the lion by the )r. // is HI authenii* i~^Zi Rcgifter of Ino( 1 Inoculator. Subjc(5l and Circumlbncc* of Inoculation. Date Day ol in- ocula- tion, Appc ■ :. No. ^?•me Aboflc. Age. Yt.|Mo Right arm. Mode of inocuta- Matter lion. whence. State of Matter. Mode of inorula- tion. Lett arm. Matter State of wlience. Matter. Firitobt tion, 4tl Right urin. ——. R L^ifter of Confultations re Date. Name of Patient. Abode. Age Years] Mcnthn. Regifter of the Diftributiol Date. Name of Applicant. Abode. State of the Matter. ' » i. 1 Rcgifter of Inoculations. Left arm. Matter [Stite of whence. I Matter. Date Uay ul iii- ocuU' tion, Appearance arid pro^^ress ol lot A nHcJlioii. Firitobsarvii- tion, 4tli day Right urin. Left arm. Seiondobicr- vatiun, 8th duy> Right 11. c-ft arm. arm. Tliir J i)l)ict- vatiuii, iiitli day. KiRhtl Left arm. arm. Fourth uliier- vatioii, i6ih day. Riglitl Left arm. arm. (Joii.^tiiutioiial Disease. Vucciiic Mutter. Ml^cell^ncou!t Remarks Syiiiptomi ai relntrd by the P.itients ur their Krieiids. Takrn on tlic 8th d ay. "r of Confuhations refpefting Vaccination. Age Years] Monthn. Cafe. Prefcription. Remarks ler of the Diftribution of Vaccine Matter. State of the Matter. Source. Distributor. Remarks. ■,*, b lucal atlctiliun. Left Kouiih (ilisrr- vatiuii, i6th ilay. Ri|;lit| I.rft arm. Rrti>. Cnii.'^tiititidiial Vactiiic Mutter. Mihcclltncuus Rcniarkt Syiii|it(iiii^ M rcliiird by tlic I'.itKtit.i (ir tlicir KriciiUi, I'.ik<'ii on tlic Kill d .ty. ition. L Prefcription. Remarks i I liter. Distributor. Remarks. ' Cow-Pox^ in their EJft'ifis o Ou, < oi, D < iinlopi'M(lcnt tit" tout. igioti ami HKirtility. lo ii'itt, 111 — — of riniis •nidst •n iiia- bu. ler am Ti\atment. Medical trcafnuiit ncccn'ary l)nth iluiinj; the disease atui after- wards. Deformity. Pits, scar", aeaniH, &c. (listigiiring the skin, and especially the face. Sliliicqut lit Diiiiisei. Scrofula in every form, disease of the skin, f^lands, joints, &(■.. blindness, doaliicss, &c. &c. X c 0. I 1-1 < •4 1/3 c r < 3 l^rcj)a- ,iict and fo5 care to bu-»'nsca- victtreines sold cidd lif sn w r< No mcdi cine requir- d. No f . •■•■" qiient ' ,.- mity nor disfij!;!!- ration. No fuhfcquent Difcafo excited. I Itate to emhract the opportunity naiv itiibittiiig Lis part toiuanh its total V hefoltoiveU iv'.th<.ut expence by the >l| )1 A comparative View of the Natural Small-Pox^ Inoculated Small-Pox^ and on Individuals and Society, o I < C/2 D H < HisTo a Y, For twelve centuries this disease has been known to continue its ravages, destroying in every year an immense proportion of the whole population of the world ! General Charader. A contagious disease : m some inflances mild, but for the most part vio- lent, painful, loathsome, and dangerous to life. Mortality One in six who havg the disease, dies; at least half of mankind have consequently one in It twelve of the human race perish by one disease ! ! In London 3000 annual ly ; in the united king dom, 40,000! Circumstances attendant and consequent on the discuses i Danger. Eruptions. I Conjlnement. One in three has the discal'e in a dangerous form. Eruptions numerous, painful, and disgusting. Losi of time. Expem Confinement, loss of time, and pence, more or less considerable, latter afledling individuals, fami parifhes, &c. A contagious disease, for the most part mild, but in some instances violent, painful, loath- some, and dangerous to life. One in three hundred noculated dies. In Lo 1- don, probably one in one hundred. The inoculation of the small-pox having been but partially adopted, has become the means of spreading the infedlion, and has thus increafed its general mortality. In London (by the bills) this increafe has been in the ratio of seventeen in |every thoufand^ One in thirty or forty has th": diseafe in a dangerous form. Eruptions of constant occurrence in greater or less numbers. Confinement, loss of time, and pence, sometimes considerable. Not contagious; and when properly conduc- ed, uniformly mild, inot fenfive, fcldom painful, tree from danger, and an infallible preventive of the sm:'l pox. Never fatal. No danger. During a long series ot years, the cow-pox, accidentally received, has been considered as a preservative against any future attack of the small-pox. Many perfons in the dairy countries, who have had the former in their youth, have remained to old age unsusceptible of the latter. With It tno'wlfdge o/tbefaSis contained in the above statement, it is presumed that no person tan cnnscientioui pravideiitiaUy -ffcred of preserving his own fan.ily frtm so dreadful and d'strubhve a pestilence as the Small- extirpation, ^xl-f neiv inoculation recommends itself to all classes : the rich are adopting it universally : their e> poor, for ivhose immediate benefit the Royal "Jeimerian Society is ^'stablisbed. Apustuleon the inocu- lated part only. Neither confinement, loss of til nor expence incurred. lated S?fiaIl-Pox, and Inoculated Cow-Pox^ in their EffeSis luah and Society, ind consequent on the diseases respetitively, independent of contagion and mort-'o "T* 10 3 3 5 5 lO lO 10 lO I I I t lO 10 lO lO lO lO ID lO 5 5 5 o I I 2 2 I 1 1 1 52 LO lo le lO lO lO lO 10 lO 10 10 -. *■' Annul! X I I 2 I 1 O e o o o o I 2 1 1 ( 57 ) Sir F. Baring, Bart. HilUftreet, Berkeley fquare .... Edwd. Baber, Efq. Park-ftreet, Grof- venor-fquare Wm. Bablngton, M. D. Aldermanbury Mat. Baillie, M. D. Lower Grofvenor ftreet Robert Barclay, Efq. Clapham Thomas Baring, Efq. Broad-rtreet iEncas Barklcy, Elq. . • John Batard, Efq. Copthall- court Benjamin Batley, Efq. Queen-ftreet Robert Batty, M. D. Marlborough-flreet Daniel Bayley, Efq. Broad-ftrcet Buildings Dr. Bayne, Bruton-ftreet Bl&ne, Efq. Portman-fquarc Mrs. Beaumont ditto Philip Bedwell, Efq. St. John-ifrect . James Bell, Efq. Little DiftafF-lane Rev. Dr. Wm. Bell, Dean's Yard, Weftminftcr .... Rev. T. Belfliam, Clapham Wm. Bennett, Efq. Mitre-court Jof. Benwell, Efq. Batterfea Thos. Bernard, Efq. Foundling Hofpital J. Bernard, Efq. French Hofpital, Old- Areet Mr. Serjeant Beft, M. P. Great Ormond ftreet ..... W. Blackburne, M. D. Henrietta-ftreet W. Blair, Efa. Great RufTell-ftreet W. Blake, E(q. Lombard-ftrcet S. Boddington, Efq. Park-lane Thomas Bodley, Efq. Lonibard-ftreet Edward Gale Boldero, Efq. Corn hill Thomfon Bonar, Efq. Old Bethlem . Mrs. Boucherett, Cumberland Place . Thomas Bradley, M. D. Parliament-ftreet R. J. Braffey, Efq. Lombard-ftreet Mofes Brent, Efq. Kirby-ftrcet, Hatton Garden .... 10 lo 5 o 5 5 lO lO lO lO 10 ID 5 5 lO lO 5 5 5 5 5 5 lO lO lO lO 5 $ 5 5 lO lo lO ID 5 5 5 5 lo lO S 5 10 10 S 5 lO lO lO lO lO lO 10 10 € - 2 2 2 Z I I ) r ¥y • ( J8 ) Timothy Brown, Efq. Lombard-ftrcet George Browne, Efq. Rotherhithe MefTrs. Brown, Cobb & Stokes, Lorn- bard-flreet .... Wm. Bryant, Efq. Mrs. Rowland Burdon, Grofvenor-fquarc James Burton, Efq. J. S. Butt, Efq. Paraxon, London-road Ifaac Buxton, M. D. Highbury-place . John Buxton, Efq. Abchurch-lane His Grace the Archbifliop of Canterbury, Lambeth Houfe Countefs Camden, Arllngton-flreet Lord Carrington, St. James's Place Sir Wm. Curtis, Bart. M. P. Old South Sea Houfe .... Chas. Calvert, Efq. Upper Thames-ftreet James Carpenter, Efq. Old Bond-ftreet C. J. Cazenove, Efq. Throgmorton-ftreet Samuel Chamberlaine, Efq. W. Chamberlaine, Efq. Aylefbury-flreet, Clerkenwell .... G. L. Champion, Efq. Wcll-ftreet, Well clofe-fquare .... Wm. Chalmers, Efq. Great St. Helen's Mrs. Chaplin, Blankney ' James Chapman, Efq. Downing-ftreet Allen Chatfield, Efq. Wimbledon . Thomas Chatteris, Efq. Cornhill Samuel Chilver, Efq. New Burlineton-ftr, John Chriftie, Efq. Great St. Helens A. Clarence, Efq. Thaxted R. Clarence, Efq. Minories Gauntlet Clarke, Efq. BafinghaU-flreet John Clarke, M. D. New Burlington-ftreet John Clay, Efq. Upper Thames-ftreet Henry CUne, £fq. Lincoln's-inn-fields lO S s. 10 5 IC 10 lO 5 5 ID 10 5] S 10 13 10 £' ^ ID 10 ID lO lO 10 lO 10 lO 10 ID 10 5 5 10 10 10 10 5 5 5 S 5 5 5 10 10 5 5 S ( 59 ) I I I I 3 I 1 I Timothy Cobb, Efq. Banbury Jofeph Cockfield, Efq. Upton . John Colcraft, Efq. 8ackvilie-ftrect Charles Cooke, Elq. Gloucefter. T. V. Cooke, Efq John Coope, jun. Efq. Osborn-ftrcct . Jofeph Coope, F/i. d° Aftley Cooper, Elq. St. Mary Axe Michael Conftable, Efq. Shad Thames James Condable, Efq. Shad Thames . -— — Cordell, Efq. Poultry H. Cowper, Efq. Clerk to the Houfe of Lords .... Thomas Creafer, Efq. Fenchurch-ftrect W. O. Cribb, Efq. High Holborn ' . Alex. Crichton, M. D. Clifford Street Richd. Croft, M. D. Burlington-ftreet W. CufF, Efq. Nurfery row, St. Geo.fields John Curtis, £fq. Whitechapel D Duke of Devonfhire, Piccadilly Duchefs of Devonfliire, d° Lord Bifhop of Durham, Cavendifli- fquare ..... Earl of Derby, Grofvenor-fquare Earl of Darnley, Berkley-fquare Countefs of Dartmouth, ditto Harry Darby, Efq. Lime ftrcet , . Mrs. Darby, ditto • T. Davifon, Whitefrlars . . . L. Davids, M. D. Rotterdam Thomas Denman, M.D. Old Burlington- ftreet Thomas Penman, Efq. ditto Jofeph Denifon, Efq. St. Mary Axe . John Dimfdale, Efq. Bartlett's Buildings W. P. Dimfdale, M.D. Grcville-llreet Dowell, Efq. Gainsford ftreet. P. Drummond, Efq. Croydon 3 3 lO 10 10 lO 5 5 5 5 lO iO 10 — 5 5 10 lO 10 10 10 10 lO 10 10 10 lO 10 lO 10 I t S 5 5 5 10 10 5 5 S 5 3 3 I 2 I a I I 1 I ' ;i ' M ( ^0 > George Duckett, Efa. Davics Street . — — Dunflon, Efq. New Broad ft. Rev. Richd. Durnford, Chiibulton near Andover .... Wm. Dyne, Efq. Serjeant's Inn Earl of Egremont, Grofvenor Place Geo. Eadc, Ef«. Fleet-ftreet John Eddifon, £(q. Gough-fquare Edwards, Efq. . . . Philip Elliott, M. D. Sambrook Court T.Everett,Efq. M.P.Manfion Houfe>ftreet Sir W. Farquhar, Bart. Conduit-Street Lady Mary Fitzgerald, Charlcs-ftreet, Berkelcy-fquare Niithan.el Fenn, Efq. Botolph-lane Thomas Fenn, Efq. York-lrreet Jolin Fenn, Efq. Cornhill Edward Fletcher, Efq. Gloucefter-place Murray Forbes, Efq. New-ftreet, Hanover Square .... Samuel Ford, Efq. Edward Ford, Efq. Golden-fquare lliomas Folh r, Elq. Bromley Hall Daniel Fowler, Efq, BilHter-lane Jofeph Fox, Efq. Lombard-ftreet W. M. Frafer, M. D. Lower Grofvenor ftrcet ..... Wm. Fricker, Efq, Holywell Mount, Shoreditch . ^ • . Thomas Froft, Efq. Goldfinith-ftreet Henry Field, Efq. Newgate-ftrcet Benjamin Fuller, Efq. • John Fuller, Efq. M. P. Devonfliire Place ..... 10 10 5 S 5 S lO lO to lO 5 5 ID lO lO ID lO lO 5 5 5 5 lO lO S 5 5 5 S 5 lO lO lO lO S 5 5 5 10 10 2 I 2 I 2 2 Z 2 ( <5i ) £' Earl Oower, Arlington-ftreet . , Countefs of Guildford, Stratton-ftreet Countefs Grofvenor, Millbank Lord Gwydir, Whitehall Lord Gardner, PortLmd-place Lord Grantlcy, Sloane-ftreet Wm. Gaitlkcll, Efq. Rotherhithe . Wm. Garrow, Efq. Bedford-row James Gibfon, Efq. Leadenhall-ftreet J. Gillam, Blackfrims Road Wm. Gillman, Efij. Fenchiirrh-dreet George Godwiri, Efq. Scot's Yard, Bufli- liinc . . Abm. Goldfmid, Efq. Great Aiie-ftrect Benjamin Goldfmid, Efq. Capcl Court A. S. Gordon, Elq. Limc-rtreet Samuel Golnel, Efq. Little Queen-ftreet A. W. Grant, Efq. Secretary's Office Rolls K^rs. Grant, d«» . . Alexander Grant, Efq, Cork-flreet . Andrew Grant, Efq. Wefl-fquare Jiarding Grant, Efq. . , Hon. Charles Grey, M.P. Hertford-ftreet B. Griffith, Efq. Lower Grrofvenor-ftreet j^arol. Griflrths, Efq. Leadenhall-flrcet H. T. Groenveh, Efq. John Gurncy, Efq. Serjeant's-inn • H Marquis of Hertford, Mancheftcr fquare M'.rchionefs of Hertford di'.to . Lord Hobart, Grofvenor-place Lady Hervey, Cleveland-row Lady Huntingfield, Grofvenor ft^Urtre Thomas Hamilton, Efq. Ncwman-flreet Wm. Hamilton, M. D. Old Broad-ftreet James Hamilton, M. D. Artillery-place McfTis. Hankey 8c Co. Fenchurch-flreet iC-r 10 — lO 10 10 lO 10 lO lO lO lO lO lO IC lO to 10 lO 5 5 10 lO lO 10 lO lO 10 10 lO 10 10 lO 5 5 S S lO lO lO lo lO lO lO lO 10 lO lO 10 s 5 10 1 X I I 2 2 I I ( <52 ) I.uke Ilanfard, Efq. Turnflilc, Holborn MeiiVs. Hardcaille & Rcyncr, Old Swan- ftairs Jofcph Harvey, Efq. Gracechwrch ftreet Wm. Hawes, M. 1). Spiul-fquiire Rev. Thos. Heineken, Brentford Wm. Henbcft, Efq. Great Prefcot-ftrcct R. Heron, Efq. MeflVs. G. R. &c W. Hibbert, Mark-lane Mrs. Heniy Hicks, Iflingion Wm. Higgins, Efq. A. Highmore, Efq. Haydon-fquare Rev. Rowland Hill, Surry Chapel iohn Hingcfton, Efq. Cheapftde lenry Hoare, Efq. Fleet-Itreet Henry Hugh Hoare, Efq, d" H. M. Hoare, Efq. FIcet-ftreet Samuel Hoare, Efq. Lombard-flrcet Wm. Henry Hoare, Elq. Fleet-ftreet Robert Holfurd, Efq. LincolnVinn . Everard Home, Efq. Sackville-ftreet Thomas Hood, Efq. Poultry R. Hooper, M. D. Marylebone Infirmary John Horsford, Efq. Ratcliff-highway H. Hughs, Elq. KingVroad, Cedford- row . ... Dr. Hume, Curzon-ffreet p. Hard, Efq. Furnlval's-inn Jol". Hurlock, Efq. St. Paul's Church-yard John Jackfon, Efq. Broad ft. Buildings S;\miicl Jackfon, Efq. Hackney , KJward Jenncr, M. D. Hertford-ftreet Mefli s. C. k G. Johnfon, Swan-ftreet, Minories . . • John Jones, Efq. Gracechurch ftreet . Ebenezer Johnfton,Efq. Biftiopfgate-ftreet Jjvimcs Joyce, Efq. Hertfordrftrcet £, s. 10 10 5 5 3 — 10 10 lO 10 5 5 10 10 10 lO lO lO lO lO lO lO S 5 lO lO S S 5 5 lO lO 5 5 lO lO lO lO 5 5 10 lO 5 S s s £, *. 2 a I I I I a s I I I I 2 2 .'V I \ I I I I ( «3 ) I I K Thomas Key, E(q. Borough Charles Kinder, Efq. Cheapfide Mrs. Thomas Kingfcote, Hinton-Houfe, Hants Colonel Kingfcote, Kingfcote, Glo'ller Mis. Knight, Cheapfide , , Corporation of the City of London Bifhop of London, St. James's-fquare Earl of Liverpool, Hertford-ftreet Earl of Limerick, Mansfield Street . Sir W. Leighton, Batfon's CofFee-houfe Felix Ladbroke, Efq. Bank Buildings Robert Ladbroke, Efq. d" Henry Ladbroke, Efq. d« Jofeph Leaper, Bifhopfgatc-ftreet , George Lee, Efq. Lombard-flreet Richard Lee, £fq, d** John Leech, Efq. Ludgate-flreet I J. Leefc, Efq. Copthall court A. Lechmere, Efq. Rydde, Worccfter Edward Leefc, Efq. Ead-flreet, Mary-le> bone Clough Leefe, Efq. Baldwin's Gardens, Gray's Inn . . J. C. Lettfom, M, D. Bafinghall-flreet H. Levyfonn, Efq. Rotterdam . . James Leighton, £fq. Welbeck-llreet Wm. Lewis, Efq. Bunhill-row Wm. Lewis, Efq. Budge-row Wm. Light, Efq. Wm. LiUer, M D. New Bridge-flrect M. B. Lirter, Rfq. J. H. Littler, Efq. May Fair Francis Lind, Efq. Bruton-ftreet . Wm. Lock, Efq. . » Thomas Lowien, Efq. Temple • r. s. $ 5 5 5 10 10 lO o lO >o lO lO lO 10 lO lO lO lO 10 lO lO 5 lO 5 lO lO lO lO lO 5 5 S 5 5 10 5 ID 5 5 5 S lO 5 5 5 5 lO 5 lO 5 10 5 10 ~°. C '• f I { 64 ) "V iM i'ii j"'? '■ M Lord Viscount Melville, Charles ftreet. Sir Henry Mildmay, Bart. Stanhope-ftreet Dr.M'Cartan, Broad-ftreet, Bioomsbury John Mackinder, Efq. Paddington Hugh Mair, Efq. Copthall-court John Maitland, Efq. Bafinghall-flrcet Mrs. Manning, Fenchurch-flreet Wm. Manfer, Efq. I^ooley-ftreet . Rev. T. Mantell, near Farnham, Surry Alex. J. G. Marcet, M.D. St. Mary Ave James Martin, Efq. M. P. Great George- ilreet .... Janes Martin, Efq. John Martineau, Efq. Lambeth James Meyer, Efq. Leadenhall-ftreet S. F. Milford, Efq. Exeter James Moore, Efq. Conduit-ftreet E. L. Mackmurdo, Efq. Bread- rtreet Mr. Charles Murray, Greville-ftreet Wm, Hart Myers, M.D. John Street, America fquare . N Duke of Northumberland, Charing-crofs Duchefs of Northumberland d° Lady Nepean, Admir. ty Office . Wm. Nanfon, Efq. F.idge-fhcet Charles Newby, Efq. Poland-ftreet R. R. Newell. Efq. Colchefter Newnham, Everett, & Co. Manfion-ho. ft. John Nichols, Efq. Red Lion-paflage J. B. Nichols, Efq. Red Lion-paflage G. Norman, Efq. Crefcent, Btidge-ftrcet Wm. Norris, Efq. Old Jewry North, Hoare & Co. Bridge-ftreet Wm. Nottidge, Efq. Bermondfey Norwood, Efq. Southwark J. Olding, Efq. Frs-'eman's-court, CornhlU £> {£' 10 10 lO 10 lO lO lO s 5 5 lo 10 lO 5 5 5 lO 10 lO ID S 5 ID lO ID 5 S lO 10 lO lO lO JO lO lO lO lO — 3 3 lO lO ID iO ID 10 5 5 IO IO 5 5 S 5 s. 2 ( 6s ) I I I I Lord Pelham, Stratton-ftreet • Right Hon. Charles Price, Lord Mayor, Manfjon Houfe Hon. P. Pufey, Grofvenor-fquare Sir John Pinhorn, Borough High-dreet Samuel Parker, Efq. Carter-lane ■■ Parkinfon, Efq. Hoxton-fquare John Pearfon, Efq. Golden-fquare Michael Pearfon, Efq. Spital-iquare jolin Pearfon, Junr. Efq. Rutland-place Samael Pett, M. D. Clapton Meffrs. Pattefon, Lee & Ifelin, Cloak-lane Wm. Phillips, Efq. George-yard Richard Phillips, Efq. George-yard Evan Pugh, Efq. Well's-ft. Wellclofe fq. Richard Phillips, Efq. Eaft-ftreet, Red Lion-fquare . . Richard Powell, M. D. Eflex-ftreet Thomas Poynder, Efq. Bifliopfgate-ftreet W. S. Poyntz, Efq. Bentinck-ltreet Wm. i*re(ton, Efq. Tooley ftreet Edward Pryce, Efq. Bucklerfbury R Lord Rous, Lower Berkeley-flreet Lady Rous, ditto Sir Walter Rawlinfon, Devonfhireplace Dr. Reece, Adam ft. Adelphi . John Ring, Efq. New-ftreet, Hanover fquure . Thos. Robe-ts, Efq. Charter Houfe-fquare Henry Robinfon, Efq. Coventry-ftreet H. Rogers, Efq. Freeman VcourtCornhill T. Rutherford, Efq. Ratclitfe Highway John Towill Rutt, Efq. Thames-ftreet 10 10 10 10 10 lO 5 5 3 3 10 10 S 5 5 5 5 5 21 — 5 jC' '- 5 5 3 5 S 5 5 lO ID 10 10 5 5 lO 10 lO lO lO 10 lO 10 10 10 5 5 5 5 5 5 I 2 I 2 2 t ( ^s ) li.iil Spencer, St. James's Place . Countefs Spencer ditto Countefs of Sutherland, Arlington-ftreet Lord Sherborne Lady Sherborne • Jjd.8oraerville,Hill-ftreet, Berkeley-fquare Lord St. Helens, Old Burlington-ftreet Wm, Sake, Efq. Poultry G. Sanderaan, M.D. Red Lion-fquare Miles Satterthwaite, Efq. Lombard-flreet J. H. Savigny, Efq. King-ftreet, Covent Garden Wm. Saunders, M. D. New Broad-ftreet Scatcherd, Efq. Avemaria-lane A. Schick, Efq. Devonfliire-fquare John Scott, Efq. Adelphi Terrace Wm. Sheppard, jun. Efq. Stylcfliill, near Frome Richard Shiells, Efq. Hampftead . . — Shuter, Efq. Gainsford ft. Horflydown Henry SifFken, Efq. Scot's Yard John SifFken, Efq. ditto James Simpfon, Efq. St. Paul's church-yard James Sims, M.D. Lawrence-lane Jofeph Skey, M. D. Union Court, Broad- ftreet Wm. Smith, Efq. M. P. Park-ftreet, Weftminfter Henry Smith, Efq. Grove hill Henty Smithcrs, Efq. St. Mary Ovcry, Southwark . . Ifaac Solly, Efq. St. Mary Axe John Squire, M. D. Ely-place John Steel, Efq. Bull & Mouth-ftrect jolcph Steele, Efq. Tower-hill • ■ Stones, Efq. ChaBdos-ftreet j. C, Stoqueler, Efq. Nicholas-lane Janses Swan, Angel Court, Newgate-ftreet £. s. lO lO 10 lO iO 10 10 IO 10 IO 10 IO 10 IO 10 IO s $ 5 5 £' •f* 10 IO 5 S IO IO IO IO 5 S IO 10 5 5 5 5 5 5 t k 2 Z I I I I 2 2 I I I I ( 67 ) 2 2 I 1 I I 1 I I I I I I I I I 1 I 2 2 I 1 I t John Tennant, Efq. Mark-lane John Thomfon, Eiq. Old Bethlem H. Thornton, Efq. M. P. King's Arms yard R. Thornton, Efq. M. P. Grafton-ftreet Samuel Thorp, Efq. Aldgate within J. T. Thorp, Efq. ditto Geo. Tod, Efq. Jofeph Toulmin, Efq. Hacknty John Towgood, Efq. Clemcnt's-lane J. Townfend, Efq. Borough Benjamin Travers, Efq. Queen-ftreet Jofejih Travers, Efq. Swithin's-lane J. H. Tritton, Efq. Lombard-ftreet J. F. TufFen. Efq. Fenchurch-dreet Thos. Turner, Efq. Great James-ltrcet Nicholas Vanfittart, Efq. M. P. Great George-ftreet, Weitniinfier J. F. Vandercom, EfcJ. Bufh-lanc W. Vaughan, Efq. Uunder Court, Min- cing Lane ... Henry Vaughan, M. D. Curzon-ltreet Jofeph Vaux, Ef<^. Spital-fquare Robert Vaux, Elq. Duke-ftreet Samuel Upponi, Warren-ftrect, Fltzroy- fquare James Upton, Efq. Chtapfide W Lady Willoughby, Bcrn'^;?.ftreet J. C. Wachfel, Efq. Smaii-pox Hofpiial R. Wainewright, Efq. Gray'c Inn-lquare John Walker, M. D. Salisbury-fquaie John Walker, Efq. I'rick-hine Charles Wall, Efq. Dcvonlhire-fquare Wni. Wallis, Efq. Fieidgate-lheet, W. Wallis, E(q. Cheaplide John Wanli y, Efq. Lothbury T. WarburtoR, Elq. Hoxton . 5 S 10 10 10 lO 20 — 10 lO 5 5 jT. s. 5 lO 5 10 5 5 lO 10 10 lO lO 5 lO 5 lo 5 5 5 ID lO 10 lO lO lO 5 lO 5 10 5 5 5 5 5 JO lO lO 5 10 lO S 5 lo to S 5 I I ( 65 ) r> i] i.a\ I ' m ') k W Jonathan Wathen, Efq, . Thomas Watfon, Efq. Bank Buildings D. P. Watts, Efq. Gower-ftreet Henry Waymouth, Rfq. Batterfea J. C. Wcguclin, Efq. New Bioad-ftreet Mr. Weflon, Surgeon, Shoreditch Wm. W-lberforcc, Efq. M. P. Old Palace Yard Roger Wilbraham, Efq. Stratton-ft» eet Robert Willan, M D. Bloomftury-fquare John Williams, Efq. Poultry Allen Williams, Efq. BoroughHigh-ftreet T. Willimot, Efq. Olapham-road Jofeph Wilfon, Efq. High-ftreet,Shadwell James Wilfon, Efq. Windmill-ftreet Mat. Wood. Efq. Falcon-fquare Wm. Woodville, M D. Ely-place S. Wooirichc, Efq. Conduit-ftreet Samuel Woods, Efq. George-yard, Lombard-ftreet . • Wydown& Lloyd, Upper Thames-ftreet Wm. Wynch, Efq. Grofvenor Place John Yelloly, M.D. Alderfgate-ftreet 5 5 lO lo 10 lO IP 10 lO lO ID 10 lO lO lO lO 5 5 5 5 ? 5 5 5 5 5 i 5 10 10 £. I Any information with refpe£t to errors, or omlffions, in the preceding lift, will be thank- fully received. *^^* Subfcribers and Benefactors tre particu- larly requcfted to give their places of abode at tli'^ time of payrac;it. Nlit ,- <1 * '■tH'ttaKmcjaaaesm-r n ( 69 ) THE PUBLIC MUST BE AWARE THAT IK AN UNDERTAKING OF SUCH MAGNITUDE, "WHERE INFORMATION IS NECESSARY TO BE SO WIDELY AND GENERALLY DIFFUSED, AND WHERE SO MANY AGENTS ARE RE- QUISITE TO CARRY THE DESIGNS OF THE SOCIETY INTO EFFECT, A VERY CONSIDE- RABLE EXPENCE WILL UNAVOIDABLY BE INCURRED. I I I I 2 2 I I THE DIRECTORS THEREFORE EARNESTLY APPEAL TO THAT PROMPT LIBERALirY, WHICH, UPON IMPORTANT OCCASIONS, HAS EVER BEEN A DISTINGUISHING CHARACi'ER> ISTIC OF THE BRITISH PUBLIC, TO ENABLE THEM TO PROSECUTE WITH SUCCESS A PLAN, WHICH INVOLVES. NOT ONLY THE DEAREST INTERESTS OF TIUMAN NATURE, AND THE SOUNDEST PRINCIPLES OF NATIONAL POLICY, 3UT THE REPUTATION OF THIS COUNTRY, WHERE THE INVALUABLE DISCOVERY ORIGT- NATED, IN THE EYE^ OF JiUROPE, AND OF THE WORLD, ,'^.5* A ( 70 ) The following form is recommended to thofc who may be difpofed to become Benefactors to the Society by their laft Will. •* I give and bequeath the Sum of (^ " out of my perfonal Eftate, to the Truftees for •* the time being, of the Royal Jennerian « Society, for the EX^fERMINATION of the "Small Pox, eftablifhed in London in 1803, ** to be applied towards the charitable defigns of « the faid Society." SUBSCRIPTIONS ARE RECEIVED BY The Rt. Hon. Charles Price, M. P. Lord Mayor. John Julius Angerftein,E{q.PallMall. Benjamin Travers, Efq. Queen Street* ■ Truftees. Meffis. Ranfom, Morland & Co. Pall Mall. Drummond & Co. Charing Cro/S. Pybus & Co. Old Bond Street. Devaynes & Co. Pall Mall. Coutts & Co. Strand. Down, Thornton & Co. Barthclomew Lane. * *' ' l l waii ' ' itt : mum ( 71 ) MeflVs. Snow & Co. Strand. Codings & Sharpe, Fleet Street. Hoares & Co. Fleet Street. Ladbroke & Co. Bank Buildings, Corn- hill. Hankey & Co. Fenchurch Street. Smith, Payne & Smith, Gecwge Street. Lees & Co. Lombard Street. Brown, Cobb & Stokes, Lombard Street. Newnham & Co. Manfion Houfe Street. Barclay & Co. Lombard Street. Robarts, Curtis & Co. Change Alley. Wdlon, Pinhorn & Co. Borough. Mr. Jofeph Leaper, Collector, No. 1 5 7, Bifliopf- gate Without. And by Mr. Charles Murray, Secretary to the Board of Directors, No. 19, Greville Street, Hatton Garden. W Phlllipi, Printtr.