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Un dee symboles suivants apparaitra sur la derniAre image de cheque microfiche, selon le cas: le symbole — »■ signifie "A SUIVRE". le symbole V signifie "FIN". Maps, plates, charts, etc.. may be filmed at different reduction ratios. Those too large to be entirely included in one exposure are filmed beginning in the upper left hend corner, left to right and top to bottom, as many frames as required. The following diagrams illustrate the method: Les cartes, planches, tableaux, etc., peuvent etre filmis A des taux de reduction diffirents. Lorsque le document est trop grand pour etre reproduit en un seui clich*. il est IWmi d partir de Tangle supArieur gauche, de gauche d droite. et de haut en bas. en prenant le nombre d'images nicessaire. Les diagrammes suivants illustrent la mithode. 1 2 3 1 2 3 4 5 6 LABORATORY OF TllK INLAND REVENUE DEPARTMENT OTTAWA. CANADA BULLETIN No. 339 SWEET SPIRIT OF NITRE :r)20— 1 ^•l.'|•I's ^ . roMM i:\TS. I'ndi r fhi- 1" ;' the work of llic Depart iii<>iit in eoiiiieclidii witli the iidiuinist ration of the Aihiitenition Aet. the Fertilizers Aet, the Feeding StulTs Act or the I'r pi)netary Meilicii.es Aet. It frecpieutly hap|)ei\s that correspoiuli iits ask information rejjardin(£ the above .\ets. of such a nature thai the matter in (piestion pos.se.sses Keneral interest, and eniiuneiit upon it wouhl prove aeeeptahh' and useftd to others than till iuHui'diate qiiestioiK r. In surh cases the reply may liiid a place in tliese coiuiiHis. For c()nvenience of reference these notes will he nutr.ben d in series. A. McdlLL, Chief AHitlynt. LABORATORY OK THF. INLAND REVENUE DEPARTMENT OTTAWA, CANADA BULLETIN No. 339. SWEET SPIRIT OF NITRE Vincent, Esc., Deputy Minist.-r of Inland Revenue. Ottawa, May 3, 1916. •f Vitro LvZl^. 4 / • vf^r* "''"" ^'Kl^'J-five (MS) samples of Sweet Spirit . .1 1,S o 'V • ^^r'-* "'•'""'"^ ^' °"' "'«l^-'"" during November •ml Lcinber ot la.t year, m the a.strict.s of ilm.itoba and Saskatchewan. , U , rfonr lltf . """^^ ''" '"''J'"""* °^ i"^P<-'^'tion under the Adulteration i'^:: -ai .BulTf ".uT"""; """"'•■ '" '''' ^"""''^'■' -•■'>• '" 1*^8 (Bulletin 1. in l.»ll (Bulletiu -';«), and m liti:i (Hulletin S.'-.S) -> -red R^Z^ *^" ^•'•"""■""""- - f°"°- f-"' «.v introductory letter to the ■n" .™'hi"'X"'." '^k"*' 'T '": ^^'-^ /"''"" "'"^'•^'■""■^ l-^^" the subject of inspec- -' '..:' ,t . 'tt :;,-, r.'"^'" '^"'' " ^'"^ VorcouU^e of adulteration; con- 1- ile E ,v^ K^fr?. riV 17""'" "?""'"• ^"* '■" ''°"t«>"ni"P '"- "f the active \ K K ^ !*"'" *'"' "''""'"■■•' ^•^^ '>-^ t''^ phnrmaooiKria requ.r.. „, ,,„ , ;,.,''T".r'" ""* '"/"'™-^ •"■"■'''»«• and emph.nsi.0,1 by the phar- ■IT.,,,, the art.clo ,s prone to decomposition and. unles. kept with sporial care ,r :..;'> f^''^^'";""^ -I'V" " riRht to expect special care on ,hc part of the n. n{ '; r'"''" '"'■'^ '•-I— •W'^ fnr the „„ality of the dr„^s he di.pcn.cT U f..liow.np tabic presents the results of three inspectio,,., of .Sweet Spiri „f r.iiii.tii.. V.-ai. Tnttil saniiil.'s. licimin,.. IMS 77 71 7.1 icimiiic. .Adnlteratofl. p. I-. p. c. .(7 M •"'7 iX rA 41 =1 1'* in - Mr m:\\ The minimiiin ninount "f Fth.vl Nifriti- roqiiirod by the British I'hiirmaropa'ia is onr iiiul flinciiinirtiTs iht ichi (t-7.">') li.v woidlit. Of th<> ciillprlian now rriHirlcil. 44 jwr iTiit ..| the .•iiiii|i|i'k i-ujilniii Iiv-h IIuiii ihi^ nmiiunt; '.W i>ir criil ciiiilinn |i" thnii I IMT <'cut •«!' V.\\\\\ Nilrilf; It i»t <'t'iil r intaiii Ic-n than iiiu-lialf of 1 jmt ciMit; while iKMirlv !) imt oMit of the ^aiiipii-s i-(mtaiii iiiiiii' at ail. ■■ Althitiiffh tile iiariic> of llic iiiiiniifaitiircr^, kt fiiriiisli,v tin- vendor, are ffiveii in their proiMT plaees in the appendeil taliji . it is but rinht I" insist that rospoiisilii]it.\ for the ipiality of Sweet Spirit of X fre ■'hoiihl re^t upon tho immediate dealer, or vendor of llie artii'le. There is no reason to believe tli.il any nninufaetiirer ol ri'pnte fnrnishe^ tliis clrn« otherwisi> than -.ip to standanl .streuKtli. The nani'' of the inannfai'turer or fnrnisher ii (Hven in aco<>r(!ani-i' witli section 1!> of the Aet, and not In iMUse of any provi'd neulineliee on his part. "It is ahiinilantly evidi'nt, in view of the eontiiuied sale of this drUK in a eon ditinn in whieli it seriously iuindJiMp-* the physieian. ami imperil- the wi'll-heinn o| tli« patient, that drnui'ists iinist ho ni;ide to reidize their resp msihility in dispensing druKs which fail t- meet the standard s^t by the pbarmacopipias. ■' Kxpcrimcnt> nnidi' by the late I'ranklin T. Harrison. Tiihlic .\n.dyst, jirovrd that Sweet Spirit of Xitre made aeioplinj; to Hritiah l'harniaeo|Ki>!d dire<-li(]ii- oaii be kept, withont change, for a yiiir. under proi)er prtM-autions. (.See Bulletin Xo. 2:1, p. 7.) . "If this ini|X'rtant driiK earn ' be procured by phy-ieians in such condition .1^ the pharmacopu'ia roiuires, it should either be n moved from the pharmacopaii altofrethcr, or ph.ysieiai/s must learn to eni|>loy it in full knowlcflge of its doubtliil charaeter and b»> prejiared for mo.-t erratic and uncertain results. "The fact is that it can he prepared and iiept by careful ami intelliKcnt dru.' Bists, and that this is not (tnc itiust be rcjiardcd as a disjiracu to the druK traiir, and a very serious menace to the public." The results of the present insiiectioii may be suinmarizeil thus: — Samplec. Found to meet H.l'. rc Total % It is to bo noted that the revised pharmaco|Hr'ia of l'.»14 makes some sliKht chaiiic in the standard for this drug as below :- - 1898. 1914. Method of preparation rnchanged. Kthyl X'itrite in freshly prepare il spirit -■>'', 2fi(!% Specific gravity 0.s:58 \,i 0.842 Kthyl Nitrite as dispensed: minimum l-'O^'r l-'ti'", " " maximum i.-.O'-. 2-fi(ic^ Since the revised pharmaco|Kria of 1014 has but recently cnmc into recognition in Canada, it i.s fair to interpret the result.s of analysis in snch a way its to conform to either the edition of 1898 or that of li)14. As a matter of fact the difTerenci>. a? far as this drug is concerned air negligible. It will be noted that, in th. lattor of speeifie gravity- otdy five f.') samples f.nll within the limits fixed by the pimrmacoivpin. Fifty-four (r>4) sample.'t have » Rpecifie gravity below 0-fi38 and twenty-six (26) Mumplcs have specific gravity above 0S42. The J«tt« are doubtle*. prtpared with weaker alcohol than W per cent Samplee (12 .n number) which do not deriato more than CSpT cent from th. nummum percentage of Ethyl Nitrite fixed by the pharmacopoeia I ^t! felt iZifiS '" '^v'"?""' ?! "PP'°«','°«'«>^ ^'"^t. •«> their ESrTNit^TtL cont^It ' ^ Nineteen (19) sample., containing lew than thi, mun be dewribd •>., nJulw .tod under the Act. The percentage of adulteraUon i. 22 .„7rndic.:l a i^^ co..,Jerable .mprovement when compared with th. reaulu oi f-rmer intStfoM I beg to recommend r^ablication of this report aa Bulletin No. 339. I hare the honour to be^ Sir, Your obedient lerrant, A. 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