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'^i m Fp" 1 '' ■pt Vi^v- •T^~r:i--i; Ottawa, October 31, 1008. Sra,— I have the honour to transmit herewith a c.py of a paper read by mo at the recent International Congress on Tuberculosis held nt Wushington, D.C. In this paper I have confined myself to that phase of the question act forth in the title, viz., 'The Control of Bovine Tuberculosis,' refraining ahno.st entirely from any mention of measures for the protection of the public against possible infection from bovine sources. Of the two problems connected with bovine tuberculosis, namely, the eradication of the disease from the herds of a country and the protection of the human race from bovine infection, tl.o latter is by far the most simple and e.i.sy of solution. Under the sj.-,tem now followed in CanalFrr^.-'rTy1-'' ^m^r^-W THE COXTHOL OF HOVINK TriiKHCILOSIS. A Paper read before Section VII. of the luternational Congress on Tubercnlosii, at Washington, DC, on October 1, 1908. Mr PRK8IDE.Nr.-It w„ul,| !,.■ ,n(.,t uiiIk .-..ininK in un: fnllnwin^f |1». varin,,. (ii'*- t.njr„Hho,i H[M.a„..r.s ,h,> l.avo takoi. ,,:,rl in th.> ,lis..MSHi,m. nf this (•„„(:,■.•«-. nnd esiK-cia ly at th.s lak> .. pro .lin^s, t., ...vup.v any k. ..t l,.„Kth of I in lay.nff Mnrr a^ members the few i.l.as on ll... e.ntrol of iJovine Tul,er,M.lo«ls wlii.h I have leen nl.le to pnt tORother in tlir limite.l i^mIo.I at ,nv .Ji^po-ul. I oliserve that on the official pro^rrnunne itie siil.j....t a.MKiM.l to mr is the 'Control oflJovme IuhereMl,.sis in Canada,' the last two v,.r,ls luuin;.' 1,., n a,!,|..l to the title originally sent in by me. I liave hut little to say on the contr.pl of h.ivine tuherr'ulosis in Cana.la inas- much as while in some district-, under municipal iiiid proviiu^al laws, .trorls are being made to control the disease in dairy lienls supplying various (vtitres of popula- tion, very little is now heinu' done l.y the fe.leral rov, rnmcnt through the Health of Anunals Brnneh of the Der)arlment of iVriculture. which i-> in my chartrr. Although for some years, nt a period prior to my assuminjr ofllce, a verv consider- able amount of tasting with tuherculin upon the application of owners was carried on, no appK^ciahle l.enefit was found to residt. and. n^^ a matter of fiu-f, we now con- tno our,e ves to the testing of cattl... imported or exported for bn-cling purposes those on the Experimental Farms, and a few other lierds which have heen plnce.l by their owners under the direct control of our ofhcers. We, however, m, the request of owiM'rs of cattle who desire them testd. supply tuberculin free of charge to any reputable qualifie,! veteriuarv surf^eon, on c(.i lition that he will send to the department the results of the te'^ts made hv him. on lai - which we furnish for that purpose. All cattle reacting to tuberculin in Canada, save those privately te^i-.i -,. permanently earmarked by cutting a lar^e T out of the right ear. I may aa well frankly state that the reason for this apparent inertia is thir -o lar no satisfactory intelligent method of dealing with K.vine tuWTculosis ha* l-n evolved and we deem it wiser, before taking action, to await the r(>su'ts of The inv.- gallons now being conducted by veterinary scientists in various countr;..s, i„ th. hope that some better way of dealing with the problem may be discovered. Our knowledge of tuberculosis, the tuberculin test, and of their vagarl, ,, has all along heen defective and incomplete and und.uibfedly is s.. to-dav, aiul when we hear in mind the many legislative mistakes wliieli, owing to this lack of exact knowledge, have l>eon made in the past, it must le admitted that caution is coiumendahle, and that, before taking any definite departmental action involving the large interests which are at stake in such a country as Canada, it is reasonable that we should ' look^ before we leap,' and guard, as far as may he, against the possibility of having to reee.le. more or less ignominiously. from a i)osition once taken. Many of our medical friends and some veterinarians whose zeal outruns their discretion, advocate compulsory testing and the slaughter of all reacting animals. At first sight, to men lacking practical expcrieu<-e and perhaps devoid of responsi- bility, this policy may ai)iH'ar a very simple solution of the problem. That it is very far fron beiuT so, however, nee U bu: litil(> denion-tr.ition to an audience of this nature. All practical veterinary sanitarians, dealing in large matters, are, c ?n without taking into consideration tlie oninfnl eviu ri,.iw.,. t^( «Vir,o,. ^o.,.« :»:„- ' .u- i. m p i .'# in earlier dav« w«ro r.nh rno.igh to B.l-i't it, well awnrc. not only oftho ^rcat diffi- cultie* to b«.'oncou.itcriid in curryiuK out siich a p-li.y. but of the fact that under ordinary cir.nnmt.inLi., in .pile of the jinnt .HM.noinio wn»to involml. lU r.-nult. are by no nioonH so antiHl'ii.'tory n^* its ailvoc'Ht<-< would liko to have ua Ulicvo. Most of u« can n-iuomlrr the time wlien the majority of vctorinariuni. many of whom should havo knoxvu bettor. lK,ii-vod th.t if n herd of oatllo w.-n- tcHKnl tho reactors .Icstruycl ami llie premises disinfoied. tho .li-ease was stnmjH'.l out and tho owmr miKlit thereafter ho left to follow his own course*. , , . . ,, . IntolliKcnt n.en have, of course. umlerK.o..,! fro,,, tho he^.nn.uK hat there muM l,e. in .he very nature of thiuRs, a ,H,-riod of latency or .ncuhatum between the time of infection and that when au mfected animal wouKI r. let to tnl-erculin. Thi. p^^riod was .ixed in m'.^ and 10( ) Kv '-on em- poraneous hut entirely in.lep<-,ulent eM,.rimc„.« carne.l on '^ •'^° '"™ Con.mittce of the Royal .\.M-ienltural So,.iety of Knuhuu and by Dr. N. car and UosHi,M.o!. under tho auspices of the SocieU', de Medecmo Veter.nu.re Pr«t..,u, of Frauce. Tiu- results in both cam h were practically the san.e at.d showed the periud of incubation, while dependir.n sou.ewhat upon t' <■ mode and .le^ree of infection, to ranee from eif-dit to fifty days. . . , , ■ i „ This fact. afTectiuK' vitally as it do s l„„h th. ong.na herd and nn.v additions or replacements which may be made, is m itself a vry sen. us obstacle to the sati-factory working out of a policy of compulsory test- ing ami slaughter, even with liberal compeu^ntioii. 1 aUen m conjunction with the vagaries of tuberculin, especially on secon.l. tliinl and fourth tcts ,n the san.e herds and the numerous iu^-euiou. methods ad ,pte 1 by owners es,H>c.ally of pure brH cattle, in order to d, feat tho te^t. it is sutlich i.t to exclude from the tield of practica aetiou this method of d.alin^' with tuberculosis, .xcept in small and circumscribe,! conunmiities. iu which all. or at least a maj .rity of the o.vuors arn fthvo o he necessity of stamping out tubercidosis a'n.l arc v.iUiiig to co-oieratc heartily with thu authorities in bringing about that result. • . i This c.iudn.iou ou mv part has not been rashly arrivcl at. Fver since tuber- culin was first use.l as a diagnostic agent in Irvine tubercub.s.s I have ben studying' ita action and during the whole of that pcrio.l my opportunities for such study havo been consi.ler.ably great..r than fall to the lot of the average vetennnnan. I ot us go a little more into detail. A -herd of. say one hundred cattb', kept under ordinary aabl, o already s-iid since maiivvot.-rinarianswero teiichiug that such a herd was safe and sound a.nl tiutt' provided any animals added were carefully teste.l before being brought into coiitn-i . no further danger need be apprehendc.l. This is. of course, very far from being tli. case. In tho first place a retest after three months will, depending t. some extent ot: the virulence of the pirtieular infection, n point of great importance, and the sani- tary conditions, reveal perhaps from five to ten new reactors. Even afte- theue hav b. en destroyed and the premises agniu disinfeete.l the herd is by no means safe. Tli. ten reactors, taking that as the number, have Ix-en living in close contact with tb. remaining sixty-live and it is quite likely that three months later, gov. ril of the latt.r will be found to be affix;ted. Here also comes into play tho nncertainty of tuU-rculi:: in repeated tests, a most serious consideration, especially where doubtful reactuu - aro concerned. In sjiito of Professor Vallc's important and valuable di-- covery, which T may say docs not by any means apply in all cases, it ■- quite within the bounds of possil)ilit,- that a number of animals, affect. 1 to a greater or less degree, will fail to react when tested for the third or fourth time. This acquired tolerance to tuberculin is one of its most serious limitations and co.;- p^;.,..trH ".nnther difficulty soniewhat hard to overcome. Let us admit, however, that :i; iia »ftcr the lupse of a lonjff-r or uliorlor \ioinf, i« in Uie iimjoriiy ol iiiKtiitictN , f imroinount importance t.. tho „wnor. It ii not .-unugh to hnv. thr. i,.'w aiiinmln test.'.l l^forn hrin^njf thfin on to tho im-miHt-M. 1 h.- Himic ilniitatioii, viz., t!.nt of tho incuhnti»o period, appliun to mioli to^ts in to tlio-i « with which w.i hivo hoou doiling. New arrivnln nmnt Im« ixohilcd, not only from iIil- orlKiimi hi-rd hut from onch othrr, and •ubmitVd to n retent at tho fxpiry of at least th.-.o months b-fon^ biinj? iiHovvrd to come in i-ontact with any other cntth*. Two further pointa here deniaiitl our attention. We have hitherto, presuninbly, been gpeikiuK of u-Mh honestly nppiied to the cnttle of nn hones-t owner un.l by a cnpnbh>, intelligent iind experienecd veleriiinriim. We must now first eoii>.id.r Konie of the nefarious methods employed by dishon'st niid unprincipled owners to nullify the test !ind «o defeat tho end in view. The old method of dosing beforehand with tubonulin, nlthuuKh still followed in many herds, hns Inrpely lost iU value tlirouRh the diwovery of Trofegsor VullO above referrivl^ to, mid is now. as a rnl.>. only employed when tho teatinj? vetoriiiuriiin is ngre«^al.:.v eoniplncent, or a few years behind bin ago. It ling, nmonj; the more astute breeders and denh'rs, been largely suptrwded by the prsetice of ndminiateriiiK one or other of tho modern nntipyretics. eoitd.ined for the sake of safety with other drugs to such animals as nre known to lie tul^ercu'-nis, or which show any rise of femtiera- turo when iiudergoing the test. This plan is beautiful in its simplieily. Temporaturos are quietly taken from half an hour to an hour before tho veterinarian nmke,s his rounds and the fcl.rifuKo, mixed with a little aupar and disguised in a han most important is the fact that in testing only thos,. herds in a country which are voluntarily submitte.1 to the authorities, the progress made in th-^ diretiou of eralic itiu,' tubjrculosis must, of necsssity, be not only verj' slow but very uncertain. Even Trofcssor Bang admits that, under the experience '-'f re,,eated i'nd often disappointing tests, the patience and courage of our Danish friends not unfrequently fail and they become weary of well-doing and relapse into carelessness. Tlrs phase of the matter is one which must he taken into account and when with it is considere.l the fact that the last to ask for the test are. as a rule the l.neders of pure-br.>d stock, whose herds are the principal agents in dicsominating disease, the ultimate imtfectivenoss of voluntary testing is pretty c'eorly demonstrated. Owners must obtain fresh blood from time to time and unless a man is heart and rail with the author: ues in :heir efforts to clean up his herd and takes every possible and minute precaution accordingly, it is. so long as tuberculosis exists in the country, only a matter of time until his stock relapses into a condition of disea.se. . 1 t> In this connection I have read with much interest the plan proposed by Ur. Mveii, M.dicnl Health Officer of Manchester, and supported by Professor Delapino and Mr. Brittlebank, the chief veterinary officer of that city, which includes the forming of disease-free islands by eradicating tuberculosis from certain farms and grrdually rxtrndiiig the work ov(r small distiicts. to be still further enlarged as the system finds favour with stork owners. features of the scheme, such as the spending Wh'le there are some the exilusion of other ta\ of public money in specially selected localities to , ^ • - pavers and the supplyimr of sanitary buildings, through bringing pre- sure to I ear on h^ndkrds cr otherwise, %\hich are scarcely applicable to conditions 11 America it is. in mv opinion, much more sensible and likely to be productive of iilti- jjjjjjg be',!-"' thnn the diffuse policy of promiscuously testing a herd here or thovi I>^>. policy of employing local practitioners for this work ha, bccT repeatSlv tr£? « , , I have nothing to say ngninst the Bang system itself • in fflft T a™ o„j i have been^ one of its most consistent adv'ocftos and lli; s " i'orttvT after thirtj- rears ejcperieoca as a veteriaariaa «««^^^^i^ .„]' -ZW' knowledge, acquired in that time, of conditions on the ordinary North AmprJ.rWa _ There is no doubt that if all our stock owners wore thoroughly intellieent woll informed anxious to rid their herds of tuberculosis and gifted with af^nfini.i capacity for taking pains, either the Ban- system or that nf O.^^r • u. . adopted with every hope of a successful i'suo AsT„.?tt, r« \ , *^ ™'^'** ^"^ to deal with bovine tu^culosis effecteillLtn^^'drfi^it^ ^leToHe^k/lS fair; ttiz ih -rrezr "^ ^^^^'^ -^ ^^-^ '-' «- -= =" °o ^om sTf r '^'^'-"-'^' --ked and s.,ro..Uod a"tl ," " ;" l/^S; from such herds to be pasteurized, whether use.l for human food ;r for that and retested after three months careful isolation purcnase, I am free to admit that this plan is open to nuiny of tlie objVvtions which I have advanced agamst the other two already meutiono.l, but it appears to ne to obviate the enormous economic waste and the tremendous popular opposition in oh!^dttl Si7ntlvanTcarf^l '"^^^^^^^^^ ''''''''''• '^ systematically applied a,S fro,^ filt f ■ "" "f""'^ °"^' '"'^"'^''^'y '"'"^■'' '•«"•*« t''"» '-"«■' be hoped for fZi them toTrr' %'!f "^ '}"' ""'■''' '' ^"''>- --<^h owners as are wiLg to suomit them to the action of the authorities. The presence of one or more actual clinical cases of tuberculosis in any herd by making not fication by owners or veterinarians cmnpulsorv, as in other scheduled Hir^Ltt^:;;:^^'- - -'^^'^ -' -^- -"•^' ^^ ^''^™. -" t^- As has heon well said by ,he editor of the LancH in conu„enting on the recent able paper of Dr. Oy..rland of Norway, the fan.ous address of Dr. Koch in 1001 has after all, by s tnnulat.ng others to investigation and research, been prod, tive of good, perhaps to an extent sufficient te offset the hesitation and del'y i . "ctua practical effort which it undoubtedly caused. h«t! ♦V''"'"'* f that address, we veterinarians to-day know, or perhaps I should say have the proofs conclusive and satisfactory of many things which wo knew befo^" but were scarcely able to prove, regarding the transraissibility to man of bovine tuberculosis and vice versa. oovine ,;fd"llt'' ^'i"!l """ ^"^ ^■"'•'■■""ti""; ■'' subject on which I have nothing to say, biyond that, up to the present. tb( 8131— iJ niiMish(>i) rcsnltc nf h bvW- ■■:7 mk:&M^4^M^ 10 it ih m ^ i si... A' ■Y, -r '>tr u I ! are, from a practical viewpoint, singularly confusing, inconclusive, and discouraging. The immunity acquired wwhr tho most fnvournble con.litions appears to bo of short duration, and any udvantnjre whicli niny be frnincd, is, to my thinkiufr, nioru thiui offset by the danger of spreading the disease. Where cultures of the human type are used the risks appear to be, if possibli', even more serious. Weber and Tirzc working under the direction of tho Gcrmnn Imperial Health Office, report, according to Theobald Smith, that the udder of a cow vacbs.lut,. reliability of tuberculin as a ■liagnostic agent. I might add .that the cattle have had no .beltor but, .ron sheds and have, ui.l, t;,e exc<_.ptioi, of n few of the weaker indivi,luals, l.,u f,,! u ,u -'t -:-.|uently inle..t,.,l through the digestive system, it als ^ to mv le.ind. shov. < tea- ... the case of adults, infection through the air passages pla.vs :>„ important part. 1 feel satasfie), and I think all practical men will agree, that had the healthv oaale in thi8 exper.merit been kept under ordinary st.ibb caiiUtioa. witli their a,.,ascd companions, they vonld not haw; .scaped as tbev have doiio _.hv .iMdK.st modieal au,;.orities are nowaciays advising, and with the v,,v b,.-t iv^siblo ivsults, ,nir modern hot-house humanity, to g, t. 'eiosrr to n-.ture' lu, v,v^ Possible wa.v The advantages of adopting a similar policy in the handlim.' .-na' I.' ':s_,u: of den-.estic nnimal= are too apparent to adnat of disoiissiou. Xatur- ha< Ivnnshed cur amiral friends with every conceivable r.quisite for proKction acaii.M o.'mar,y climatic conditions .and most of the diseases a.:d di-Td.ilities to which tb-v ar- subject have been caused by and owe their continuance to the irrational artificial ci.litions imposed upon them by well-meaning but ipnor«nt. or rather unthiukin- '■" ::ers and attendants. "^ \ ain hore. howTver, lw loam and not to teach. The pi-obl.n, of the Control of ti ■ ine Tuberculosis is undoiibtelly thj most 3Jrwa^ oifroatiii? t!i- veteriuM-v ^.l• -nrian of to-day, and if the labo^urs of this section of the Tnternational Congress ii' It m U& solution, I lor one will be forrver grateful. t 'N.i.'t ,^ _^> Fr^--t^-f^ficyr^.,.. .T^^^--^.