IMAGE EVALUATION TEST TARGET (MT-3) 1.0 I.I '"IIIIIM IIIIM S IIIIM ^ IM (14 12.2 2.0 1.8 1.25 1.4 — i : J4 6" — ► % V] /. A .^v C»., ' 0%. '--^ //A 'w '/ Photographic Sciences Corporation 23 WEST MAIN STREET WEBSTER, N.Y. 14580 (716) 872-4503 iV rIS •N5 4> 6^ CIHM/ICMH Microfiche CIHM/ICMH Collection de microfiches. Canadian Institute for Historical Microreproductions / Institut Canadian de microreproductions historiques Technical and Bibliographic Notes/Notes techniques et bibliographiques The Institute has attempted to obtain the best original copy available for filming. Features of this copy which may be bibliographically unique, which may altor any of the images in the reproduction, or which may significantly change the usual method of filming, are checked below. D D D D D D D D □ Coloured covers/ Couverture de couleur Covers damaged/ Couverture endommag^e Covers restored and/or laminated/ Couverture restaur^e et/ou pellicul6e Cover title missing/ Le titre de couverture manque Coloured maps/ Cartes gdographiques en couleur Coloured ink (i.e. other than blue or black)/ Encre de couleur (i.e. autre que bleue ou noire) Coloured plates and/or illustrations/ Planches et/ou illustrations en couleur Bound with other material/ Reli6 avec d'autres documents Tight binding may cause shadows or distortion along interior margin/ La reliure serr6e peut causer de I'ombre ou de la distortion le long de la marge intdrieure Blank leaves added during restoration may appear within the text. Whenever possible, these have been omitted from filming/ II se peut que certaines pages blanches ajout6es lors d'une restauration apparaissent dans le texte, mais, lorsque cela 6tait possible, ces pages n'ont pas dt6 filmdes. Additional comments:/ Commentaires suppldmentaires; L'Institut a microfilm^ le meilleur exemplaire qu'il lui a 6t6 possible de se procurer. Les details de cet exemplaire qui sont peut-dtre uniques du point de vue bibliographique, qui peuvent modifier une image reproduite, ou qui peuvent exiger une modification dans la mdthode normale de filmage sont indiquds ci-dessous. D D D D Q D D D Coloured pages/ Pages de couleur Pages damaged/ Pages endommagdes Pages restored and/or laminated/ Pages restaurdes et/ou pellicul6es Pages discoloured, stained or foxed/ Pages ddcolor^es, tachet^es ou piqu6es Pages detached/ Pages d^tach^es Showthrough/ Transparence Quality of print varies/ Quality indgale de Timpression □ Includes supplementary material/ 0« Oomprend du matdriel supplementaire Only edition available/ Seuie Edition disponible Pages wholly or partially obscured by errata slips, tissues, etc., have been refilmed to ensure the best possible image/ Les pages totalement ou partiellement obscurcies par un feuiliet d'errata, une pelure, etc., ont 6t^ filmdes A nouveau de fapon d obtenir la meilleure image possible. This item is filmed at the reduction ratio checked below/ Ce document est filmd au taux de reduction indiqu6 ci-dessous. 10X 14X 18X 22X 26X 30X y 12X 16X 20X 24X 28X 32X :ails du )difier une nage The copy filmed here has been reproduced thanks to the generosity of: National Library of Canada The images appearing here are the best quality possible considering the condition and legibility of the original copy and in keeping with the filming contract specifications. L'exemplaire film6 fut reproduit grSce it la g6n6rosit6 de: Bibliothdque nationale du Canada Les images suivantes ont 6t6 reproduites avec le plus grand soin, compte tenu de la condition et de la nettetd de l'exemplaire fiim6, et en conformity avec les conditions du contrat de filmage. Original copies in printed paper covers are filmed beginning with the front cover and ending on the last page with a printed or illustrated impres- sion, or the back cover when appropriate. All other original copies are filmed beginning on the first page with a printed or illustrated impres- sion, and ending on the last page with a printed or illustrated impression. Les exemplaires originaux dont la couverture en papier est imprimde sont filmds en commenpant par le premier plat et en terminant soit par la dernidre page qui comporte une empreinte d'impression ou d'illustration, soit par le second plat, selon le cas. Tous les autres exemplaires originaux sont film6s en commengant par la premidre page qui comporte une empreinte d'impression ou d'illustration et en terminant par la dernidre page qui comporte une telle empreinte. The last recorded frame on each microfiche shall contain the symbol ^^ (meaning "CON- TINUED "), or the symbol V (meaning "END "), whichever applies. Un des symboles suivants apparaitra sur la dernidre image de cheque microfiche, selon le cas: le symbols ^^- signifie "A SUiVRE", le symbole V signifie "FIN". Maps, plates, charts, etc., may be filmed at different reduction ratios. Those too large to be entirely included in one exposure are filmed beginning in the upper left hand corner, left to right and top to bottom, as many frames as required. The following diagrams illustrate the method: Les cartes, planches, tableaux, etc., peuvent dtre filmds d des taux de reduction diffdrents. Lorsque le d'. cument est trop grand pour dtre reproduit en un seul clichd, il est film6 d partir de I'angle supdrieur gauche, de gauche d droite, et de haut en bas, en prenant le nombre d'images ndcessaire. Les diagrammes suivants illustrent la m6thode. rrata o )elure. H 32X 1 2 3 1 2 3 4 5 6 1 i'V^ .11 NATI pj Author ol Ec Member ( c. w. c 1^' I' " InX. CONSUMPTION : / ITS NATURE, CAUSES AND PREVENTION; WITH AN OUTLINE OF THE PRINCIPLES OF TREATMENT, FOR ALL CLASSES OF READERS. BY EDWARD PLAYTER. M.D. (And Medallist, Toronto Univ.>, M. C. P. & S., Ont. Author of " Playter's Physiology and Hygiene" (authorized by the Ontario Education Department), Editor of the "Canada Health Journal"; Member Canadian Medical Association, American Public Health Association, and American Academy of Political and Social Science, TORONTO: WILT^IAM BRIGOS, WESLEY nUH.DlNGS. C. W. COATES, Montreal. S. F. HUESTIS, Halifax. 1895 Entered, aecoi-ding to the Act of the Parliament of Canada in the year one thousand eight hundred and ninety-five, by William Brioos, Toronto, in the Office of the Minister of Agriculture, at Ottawa. PREFACE. The object of this book is sufficiently indicated in the title and introductory chapter. All readers of the book, the author trusts, will kindly overlook the many imperfections in it. It is not expected that the book will in any way or degree supersede the two or three other works which liave been pubhshed with a like object. The aspira- tion is to simply assist in the goo<l work. While the book is intended for all classes of readers, professional and unpi'ofessional, the author hopes it will be appreciated and largely read by members of the medical profession, who are ever foremost in efforts for promoting the public health, and many of whom, alas! become victims of consumption. Being apparently the latest of the books published on this subject, and, it is believed, " up to date " in most respects, it may contain something that is in a measure new: — as in relation to the body or soil factor, and also to this being the immediate exciting cause of the disease and the one which it seems desirable and practicable rather to attack first, or with our principal forces, in preventive efforts; to the probable and possible sources, such as that of domestic animals and {/ IV PREFACE. that of a possible open air growth, of the other principal causative factor, the tubercle bacillus; and to the nature and degree of the infectiousness, and the de novo origin, of the disease. That the book may be instrumental in preventing human suffering and preserving human health and life is the earnest hope of The Author. Ottawa, November, 1895. ; TABLE OF CONTENTS. PART I. NATURE AND CAUSES OF CONSUMPTION. CIIAITKR I. Introductory. PAGI Nomenclature — Prevalency and Cost of the Disease — It is Communicable and Preventable — Two Prime Essential Causes — Curability of Consumption — Know- ledge of Breathing Necessary 9-18 II. The Ldnos and Their Functions, or Uses. What is Respiration ? — The Respiratory Organs : The Lungs— The Air Tubes and Cilia— The Chest Walls and Pleura — The Breathing Acts and Lung Capacity — The Blood and the Breath in the Lungs — The Poisons in Breathed Air — Poisonous Effects of Prebreathed Air — The Oxygen in the Body — Important Facts — Proportionate Chest Dimensions — The Lungs may be Enlarged 19-37 III. Nature and Characteristics of Tubercular Pul- monary Consumption. What is Consumption ? Its Different Forms and Names — What is Tubercle? — The Tubercle Bacillus — Laboratory Cultivation of the Bacillus — Sporing and Multiplication — Relations of the Bacillus to the Disease — Whence Comes the Tubercle Bacillus ? — Saprophytes and Parasites — Tubercle in Other Tissues and Animals— Simple Ex- aniples of Parasitic Diseases— Formation and Progress of Tubercle — Antagonistic Body Forces— The Changes are Inflammatory — Diffusion of Tubercle in the Lungs — Further Diseased Conditions— The Brighter Side . 38-62 VI CONTENTS. M CHAPTER IV. CaDSKH of TlUKlKHLAR PlLMONARV CONSl'MPTION. iMHKItKKT KkSPIKATION AS A CaUSK. (Jeneml HeinaikH : Half Knmedies — Two KsHontial Agents : Authorities On — Predisposition : What is it? — Vegetation autl Soils -Retained Body Excreta: Carpenter's Theory — Who Take Infectious Diseases '! — Of the Poisons (ienei'ated in the Hody- Aie Dis- ease (Jernis Originally Benign ';— EH'ects of Environ- ment on Disease (Jerms — Dormant or Ljitent (iernis in the Body — Effects of Imperfect Breathing — Special Collective Investigations — Experii .ents and Opinions of Others — Corroborative Evidence — What may be said Against this View — Bespecting Cause and Effect— Concluding Facts and Deductions . . PAOE 63-119 V. Causes ok Consumption Continukd. AS a Causk. Hkkedity General Remarks — Statistics Bearing upon Heredity — Heredity as Relating to the Tubercle Bacillus — Heredity and the Body Factor or Soil 120-134 VI. Causes of Consumption Continued. Want of THE Natural Body Defences as a Cause. The Protective Walls— The Phagocytes and Blood- Serum Antidote 135-141 VII. Causes of Consumption Continued. Remote or Secondary Causes from Habits and Con- ditions of Life. Impure, Prebreathed Air — Want of Sunlight a Cause — The Neglected "Cold": Weather and Climate — The Soil and Dwelling-House — The Diet- ary : Cookery — Occupation, Tobacco, etc. . . . 142-156 VIII. Causes of Consumption Continued. The In- fectiousness AND CoMMUNICABILITY OF THE Disease. General Remarks on Infection — History of the In- fection Theory — Historical Evidence of Infection — CONTEXTS. CHAPTICR Vll PAOK [ Statistical Evidence of Infection— Hist )ry of In- dividual Instancea and Cases — Kxperiuiental Evi- dence of Infection— Circuin8tancc< Modifying the Above Evidence — Evidence Opposed to tlie Infec- tion Theory — A Degree of Infectiousness Fairly Established 157-184 IX. Causes of Consumption Continued. Sources AND Dissemination of the Bacilli. Human Sources of the Bacillus — How tiie Bacilli Enter the Body: Inhalation — Interconiinunicability: Infection from Animals — Tlie Bovine Pace a Source of the Bacillus — Flesh and Milk Source of Infection 185-19.5 X. Causes of Conscmi-tion Continued. De Novo Okkjin of the Dihkase. Does the Bacillus Grow Outside the Body? — A Pos- sible Lower Animal Origin — Consumption not ahva^'s from Infection — Oversight and Isolation not Suf- ficient — The Body Factor : Pretubercular Condition — The Body Condition must be Prevented — Deduc- tions : Conclusion of Parti 196-211 PART II. PREVENTION OF CONSUMPTION. XL Practicability and Facility of Prevention — Prin- ciples of Prevention : Lines of Action — Pure Im- pregnable Bodies First -Attention to Minute De- tails—Division of the Subject 212-225 XII. General Essentials ok Health. Pure Fresh Air First — The Soil — Dwelling- House — Ventilation : Its Importance, Cost, etc. — Sunlight — The Dietary : Foods, Cookery— (ieneral Bathing and the Skin— Some Other Essentials — Overwork — Sleep— Rest 226-246 Vlll CONTENTS. CHAPTRR rAOB XIII. Si'KciAL Individual Prbvkntive Mkasures. General Respiratory Exercise— Special Lung Exer- cises—How to Keep Out of Doors — Occupation Considered — Digestive and Nutrient Foods — Pre- venting "Colds": the Cold Batli— A Few Words to Parents — Marrying and Giving in Marriage — Avoid- ing and Preventing Infection — The Spittle and Other Excretions Protul)ercular Preventive Mea- sures 247-282 XIV. State and Municipal Prbvkntive Measures. Lines of Legislation — Preventive Education — Stricter Measures : Better Inspections — Sub-soil Drainage - Meat and Milk Regulations — Public Ba hing Conveniences — School Pupil Management — Official Management of Cases — Hygiene of Domestic Animals — Sanatoria or Hospitals for Consumptives. 283-297 XV. Climate and Prevention. What is Climate ? — The Atmosphere and the Body Functions— Classification of Climates — Ocean Cli- mate — High Mountain Climate — Elevation is not Necessary — Forest Climate — Acclimatization — Change of Climate Uncertain and Empirical — Essential Climatic Elements or Conditions— Special Local Influences and Conditions —Select, Home Cli- mate — Climate of Canada and Adjacent States . . 298-328 PART III. XVI. Relating to the Treatment of Consumption. Diagnosis : Diflferentiation— Some Signs and Symp- toms of Consumption — Early Treatment : Delay Most Dangerous — The Patient and Physician — Indications and Remedies 329-340 CONSUMPTION: ITS NATURE, CAUSES AND PREVENTION. PART I, NATURE AND CAUSES OF CONSUMPTION. CHAPTER I. INTRODUCE JRY. NOMENCLATURE. In this treatise, it is my purpose tu confine myself to that "wasting" disease of the lungs commonly called Consumption (from the Latin \vor<l consumo ; originally, to take the whole of anything — hence to eat, waste away, bring to naught — to consume). The disease is more accurately termed pulmonary con- sumption — consumption of the lungs (pulmonary, from the Latin, pulmonis, a lung). Furthermore, from the peculiar tuber-like or knob-like masses — tubercles — of disease-substance or tissue, which form in the lungs in this disease and which are special characteristics of it, it is yet more accurately and technically termed tubercular pulmonary consump- tion. Suck tubercles, moreover — tubercles of pre- cisely the same history and character — form in many other organs and tissues of the body as well as in the 10 CONSUMPTION 11 lungs, especially in the bowels, and hence the term, consuTnption of the bowels. Hence, too, the technical term, tuberculosis, which is gradually coming more and more into use, particularly with reference tu domestic animals. Again, in many cases, two or more or many of the bodily organs become the seat of these tubercles, or of the disease, at the same time, and to these cases we apply the term, " general tuber- culosis." Consumption and tuberculosis are in this connection synonymous terms. Phthisis, the Greek word for wasting away, is* another technical, classical name commonly given to the disease, especially by physicians. The term consumption, however, is in most common use, the disease is best and most generally known ]>y that name, and it is therefore my purpose to adhere for the most part to this less technical word. Further- more, when the word consumption is used herein, unless otherwise designated or explained, it means tubercular pulmonary consumption — consumption of the lungs — this being by far the most common form, the lungs being the most connnon seat, of the disease. It w411 be well to observe here, and for the reader to bear in mind, that, in using means for the pre- vention of the lung disease w^e at the same time combat, more or less successfully, all the other forms of consumption. PREVALENCY AND COST OF THE DISEASE. Consumption is such a very prevalent and fatal disease in almost every country in the world, in both ITS NATURE, CAUSES AND PREVENTION. 11 man and the domestic animals, that hardly any subject can be of greater importance than that which relates to its prevention. It is a subject which concerns every individual, of every age, high, low, rich and poor, almost alike ; for so wide-spread is the disease that no one is exempt from it or its influences. As Doctor Irving A. Watson (Sec. Am. Pub, Health Assoc, in pamph.. Prevent, of Consump.) graphi- cally gives it ; " In many geographical divisions of the world it invades almost every community. It comes with such an insidious and silent tread that its footfall is unheard. It seizes its victim with such a gentle and tender grasp that its hand is unfelt till its finger has painted the hectic flush of its first con([uest ; and in a few weeks, a few months, or perchance a few years, it has attained its ultimate victory — death. There is no life too pure, no face too sweet, no form too lovely, for its unrequited passion of destruction. It is the crowned king of mortality before whose edict we have too long bowed our heads in ignorant and sometimes reverential submission." In its various locations in the body, consumption causes from one-sev^enth to one-fourth, according to climate and locality and the habits and manner of life of the people — probably on the average, one-fifth or more — of all the deaths of the human race, and it has been aptly termed the " Great White Plague." In England, pulmonary (lung) consumption alone still causes about as many deaths every year as did small- pox a century ago, or about one-tenth of the totals. Nearly half a century ago, the late Sir James Clark, w ^^: 12 CONSUMPTION : 11 M.D., wrote (Cyc. of Pract. of Med.) : " It is not advancing too much to state that, among the whole range of human infirmities, tuberculous diseases are the most deserving the study of the physician, whether we regard their immense frequency or appalling mortality. Confined to no country, age, sex, or condition of life, they destroy a larger proportion of mankind than all other chronic diseases tocfether." Moreover, with the exception of certain limited localities in England and on the Continent of Europe, of armies and navies and a few public insti- tutions, where from certain or better hygienic regula- tions and administration in recent years the disease has been less prevalent, it appears to be generally increasing in frequency. From the usual slow progress of the disease, from the long period of debility, sickness and inability to work, which almost invariably accompany it, the actual money outlay for medical attendance, medi- cine, nursing, etc., which it calls for — aside from the loss of time and incalculable amount of suffering and the deaths — is vastly greater than that of any other disease. IT IS COMMUNICABLE AND PREVENTABLE. Consumption is, in a measure, an infectious or communicable disease ; that is, the seeds or germs of it sometimes proceed directly from another person or animal affected with it. This is now almost uni- versally conceded by authorities. Where, therefore, no special measures to prevent its spread are made use ITS NATURE, CAUSES AND PREVENTION. 13 of it is but natural that it should increase in frequency. That it is not virulently or highly infectious, how- ever, is apparent to any observer ; and this probably for. these reasons: the infective particles or germs are not given off so abundantly from an infected body as in the case of many other infectious diseases ; they multiply slowly ; they have not such great vitality or virulency as, or they are more easily ren- dered inert or destroyed by a low or high tempera- ture than, most other germs ; and they do not so readily adapt themselves to surrounding conditions, requiring a more especially adapted, receptive, non- resisting soil within the human body in which to develop and grow : just as in ordinary vegetation the seeds of some plants are much less abundant than of others, multiply more slowly, are more easily killed, and will not take root and grow in such soil as the seeds of other plants will readily spring up in and I reproduce themselves in abundance. Practically, then, it need not be treated with such extreme preventive [or sanitary measures as are necessary in the manage- [ment of most of our epidemic, infectious diseases. Consumption is now universally regarded by the [medical profession as being prevental)le, as are more especially all diseases which are infectious, or com- jinuiiicable from one person to another. Moreover, lanyone who will examine into its now well-known jcauses cannot fail to see that it is not only prevent- lable but that it may be more easily and surely )revented than the more actively infectious diseases [Vvhich prevail epidemically, the prevention of it being r ^mm. \'U In 1 liiii ili 14 CONSUMPTION in each case more in the individual's own hands. Many persons, unhappily, even amongst the more in- telligent classes, look upon consumption as something to which certain predisposed human beings are so naturally subject that prevention in such cases is im- possible ; yet, when once symptoms of its presence become manifested in such persons there is usually no hesitation in at once resorting to means for its cure — alas ! too often when too late. It is remarkable, considering the great fatality of this malady, that more general special attention has not heretofore been given by sanitarians to its prevention. Those interested in public health work have bestowed their thoughts and time chiefly on those diseases which prevail epidemically and in a short period of time destroy many lives, while this abiding disease, ever cutting off, after months and years of almost hopeless suffering, vast numbers of lives, often the brightest, most useful, most valuable, frefjuently in the best period of life, has not received due practical consideration. " Were the annual deaths from this affection to occur in a few days instead of a year, the public would require no urging to be convinced of the absolute need of strictly observing preventive measures" (Burt). Health authorities from time to time issue pamph- lets of instructions on the prevention of diphtheria, small-pox and scarlet fever, but very little in this way has yet been done for the prevention of consumption, a more preventable and more destructive disea.se. A ITS NATURE, CAUSES AND PREVENTION. 15 commencement in this way, however, lian been made jind tlie prospects are improvinj^. Statistical evidence is not wanting to prove that the inortaHty from consumption has been lai'gely reduced in certain localities by sanitary or preventive measures, although these measures were not usu dly specially in- tended to prevent this disease. For example, accord- ing to Doctor Thorne Thorne, Chief Medical Officer of the Local Government Board, of England, in the period 1804-08, the consumption death-rate in Eng- land and Wales ranged from 2.002 to 2.380 per million living per annum; whereas, during the period 1884-88, the corresponding rates had fallen to 1.752 and 1.541 })er million. T^iis marked diminution. Doctor Thorne ways, though doubtless in part a matter of nomen- clature — of recognizing and more correctly naming lung diseases — " has without (juestion been largely assisted by the improvements that have taken place ill the general conditions atlecting the population " — improvements in lodgement, employment, feeding and clothing, more out-door exercises in the young — " and ; a number of other matters which have gone to diminish a tendency to catarrhal maladies, the aggravated I recurrence of which tends to induce a condition favor- able to the development of pulmonary tubercle." Again, in the army and navy, by providing more space per man in housing or barracks and better ven- tilation, the proportion of deaths from the disease [amongst the men has been thereby greatl}^ reduce<l. Now, it will be well to note here, at once, that, in [the prevention of consumption, there are mmmmm ^ 16 CONSUMPTION liii Mli: ilijl IH!" TWO PRIME ESSENTIAL CAUSES or conditions which must always be taken into con- sideration : namely, ( I ) the germ or seed, the infec- tion ; and (2) the special, fit soil, the receptive non- resisting body, in which only the seed can gi'ow. While it appears clear that no soil, no condition of the human body, however fitting, can give rise to tubercular consumption until the special seed — the infective germ — has been sown or has fallen or found its way on to it, any more than the most suitable soil can produce thistles or mustard without the seeds of these plants, neither can the infection or seed of this disease develop and grow and give rise to the disease unless it find or fall upon the special, as it were pre- pared, soil or condition of body. T^ is is a most important point to bear in mind in all efiforts for the prevention of the disease. CURABILITY OF CONSUMPTION. While the prevention of the disease should be the first aim, it should be remembered that consumption is curable as well as preventable — curable in its earlier stages. Of this there is abundant convincing evidence. Some persons are cured of it in general medical practice, after it had been clearly "seated;" while many hospital patients who died of other diseases have given unmistakable evidence, on post- moi'tem examination, that they had had the disease, although it had long before ceased to be progressive and the scars alone were left. Most of the patients, so far as could be learned from their history, never I'll! III! ITS NATURE, CAUSES AND PREVENTION. 17 know that they had had it. The cure had been, per- haps, brought al)Out simply by a change on the part of the individual from an in-door life to an active one out in the pure air and sunshine. It is, tlierefore, a mistake to regard those who have contracted the disease as being necessarily doomed to die of it sooner or later and all treatment as only palliative. There is not, however, it may be here clearly and positively stated, any specific for the cure of con- sumption, all the promises of charlatans, as through misleading advertisements in papers or otherwise, to the contrary notwithstanding. The treatment of it by the best physicians is on general principles, in accordance with the particular condition of each indi- vidual case, no two being precisely alike ; indeed, it is almost entirely of a hygienic character, as it is termed, consisting mainly of such means as, when early em- ployed, prevent the development of the disease. KNOWLEDGE OF BREATHING NECESSARY. In order that consumption may be most success- fully combated and prevented, it is essential that every person should know something about the nature, character and causes of the disease, and there- fore something, too, about the structure and functions j of the lungs and the nature of respiration — the func- tion of breathing. Nearly all consumptives, if not all, have a propor- tionately small or limited respiratory capacity or [action — proportionately small lungs, perhaps, from heredity, or if not small, the use of them is limited 2 18 CONSUMPTION : II from habits of life; hence the function of respiration | in these persons is but imperfectly performed. Much of this is from ignorance. Few know the nature or I importance of this function. Breathing we may regard as the most vital andl important of all the functions of the body. It is. therefore, most desirable that every body should know how to breathe properly. Many persons doj not know. It will then be best to devote a few pagesl here to a brief description of the lungs and their uses. A little knowledge is a " dangerous thing " only toj those who presume too much on that little, who do| not use it properly but misuse it. i!!" II ITS NATURE, CAUSES AND PREVENTION. 19 in CHAPTER II. V-j- |THE LUNGS AND THEIR FUNCTIONS, OR USES. WHAT IS RESPIRATION ? |Respiration (from the Latin prefix, re, and spirare, to breathe — i.e., to breathe again) is that function by "wliich an interchange of gaseous substances takes )lace between the inner parts of a living body and the air or water in which it lives. Animal bodies take in oxygen and give out carbonic acid gas ; vege- table bodies take in carbonic acid gas and give out )xygen. In the higher animals the special organs for this interchange of gases are the lungs ; in fishes, the rills : in plants, the leaves. As through the stomach the food eaten gets into the blood, so through the Jungs, oxygen — gaseous food — gets into the blood. Int the lungs are something more than nutrient )rgans; they are largely excretory organs, too, for throwing off waste matters. A lung is simply a broad, yet much folded, very hie, delicately constructed, transparent membrane, rith one surface exposed to the air in the lungs, while [he blood in minute vessels is spread out on the other. 50 broad is this membrane that it is said, if it were bread out its surface would be thirty times that of [he skin of the body. Gases pass readily through it, jl^^^K- 1^' 20 f;()NsrMi»Tiox m< just as air passes through fine muslin ; and the oxyjroii| of the air in the lungs passes through it into the blood while at the same time carbonic acid and other sul> stances from the blood pass out and are expelled. Out-door atmospheric air consists of about 21 1 per cent, of volume of oxygen, and seventy-nin(| of nitrogen, with varying proportions of watery vapoi-, less than a two-thousandth part of carbonic acid gas I and mere traces of ammonia and other gases. Thtl maintenance of tho higher animal life depends upoiil and necessitates a continual taking in or absorptioiil from the air of oxygen and a small proportion ofj nitrogen, and a throwing off or excretion into the airj of carbonic acid, with watery vapor and a poisonous nitrogenous vapor. The object of respiration is thel interchange of these sub-tances between the bloodj and the outer atmosphere. The lungs — the speciall organs of respiration, are most wonderfully and beautifully constructed for exposing the blood to thel atmosphere in order that such interchange may take place. The blood, after it has circulated for a fe\vj moments throughout the entire body, or has been thtj round of the greater circulation, is pumped to thti lungs, and it is necessary that the atmospheric ain with its oxygen shall flow freely, abundantly, throu^li the lungs — into them and out of them — to meet ther^ the blood spread out to be bathed and purified b}J the air. If this remarkable process by which we take int the body atmospheric air with its indispensable life] giving oxygen, and throw off" out of the body carbonii ITS NATURE, CAUSK8 AND PREVENTION. 21 ic'ifl and other poisonous excrete matters, l>e suspended, life is almost at once extinj^uished. IF, iiKlced, the )rocess be even interfered with, and not ])i'()perly and [•ompletely carried on, the other vital processes are SDon obstructed and retarded, all the functions of life u-e impaired, and want of stamina, general debility irid ill-health ()uickly follow. i* THE RESPIRATORY OR(JANS— THE Ll'X(}S. The lunj^s are made up, then, of two vast mem- )ranes — one for each lung — so folded or puckered IS to form minute cavities, called air cells or air jhambers, giving great expanse of surface wliile ^'et occupying as little space as possible consistent kvith their function. Little tubes, called bronchial tubes, lead to these little cells or chambers from larger tubes which extend from the wind-pipe — or [rachea, for conveying air into the chambers. The lir chambers are of various irregular forms, from nutual compression or packing together, and each ; covered with a close net-work of minute blood re.ssels, called capillaries, so that the blood is on the bter surface of the air chambers, while the air is nthin them. The air chauibers cluster around the ittle tubes and branch tubes, somewhat like grapes ipon their stems. They are so small as to be hardly fistinguishable by the unaided eye. Arteries and kins, extending along beside the bronchial tubes, ^ranching again and again, as the tubes branch, con- [ey the blood to and fro between the blood capillaries |ii the air chambers and the heart. The two lungs, • h (i ifni fvi T" Ir Hi! '!^ li i 'ill jiini |l ' : H ill! : 1 , 1 , i 1 i il , :i ' ■ 1 il i! if 22 coNsuMnioN : with the heart and other large vessels, fill the chest. Each lung is somewhat cone-shaped, with the small end terminating in a thin edge, called the apex of the lung, situated behind and a little ahove the collar- hone, or clavicle. After air once enters the lungs at birth they always contain some air, feel spongy or elastic on pressuix-, and will float on water; hence, the vulgar name, " lights." The membrane forming the air chambers i.sl elastic and will stretch considerably, as one will find on blowing into the lungs of a small animal. THE AIR TUBES AND CILIA. The windpipe, or trachea, is a stiff tube, containin*,' rings of cartilage which resist pressure and prevent closure of the air pas.sage. Below, it divides into two! large bronchial tubes, one for each lung, the right and left bronchi. These divide and divide into smaller and smaller tubes, which extend to all the air cham-l bers. Above, near the throat, the trachea swells out| into a larger tube, or sort of box, called the larynx, which contains the vocal apparatus. All the air passages — the windpipe, and large and I small bronchial tubes — and also the air chambers, are lined on tlie inner or air surface with a layer of minute cells, called epithelium. This epithelial layer! is somewhat similar in structure to the cutis — thel outer layer of the skin ; but instead of being dry, like the cutis, it is moist and soft like that lining thel mouth. Like the cutis, it is gradually shed or worni off and renewed. On the free surface of it, extending! ITS NATURE, CAUSES AND PREVENTION. 23 from the larynx to and throughout the smallest bronchial tubes, though not into the air chambers, are most mimite, hair-like processes, set closely together, i;ull('<l cilia. They are about 1-5,000 of an inch long, one end being free while the other is attached to the layer of cells or epithelium, resembling in their urrungement the pile of velvet. The cilia are in incessant vibratory motion, which, under the micro- scopt', gives to the eye of an observer an impression similar to that given by the surface of a Held of ripening wheat when moved by the wind. These movements produce a continued current outward, and tiuu ' u'eign substances, as particles of dust, or excess of mucus, as when one has a " cold," coming in con- tact with the cilia are conveyed from the deeper parts of the lungs to the windpipe to be coughed up. ! 11 THE CHEST WALLS AND PLEURA. The walls of the chest are formed chiefly by the ril»s, with two layers of muscular fibres, the intercostal muscles, stretching between each pair, for the purpose [of moving them. Tlie ribs are attached behind to [the spine, each by a movable joint, and as one may [see by examining one's own ribs or those of another I person, they are considerably lower in front than at [the spine, so that when the front ends are raised by [the muscles, the breast bone, or sternum, is lifted and moved forward, and thus the depth of the chest is in- I creased. The breadth of the chest is at the same time increased by the rotatory elevation of the central part of the ribs, at the sides, somewhat as the half-circle '!i 11 illi I iiiii ■iiil! jiiiil 24 CONSUMPTION : handle of an ordinary wooden bucket is raised. The floor of the chest, dividing it from the belly, or abdo- men, is formed by a broad, thinnish, but strong muscle, the diaphragm, which curves up dome-like into the chest. When its fibres contract, it becomes flatter and presses downward the contents of the abdomen, as one can feel by placing one's hand on the stomach when drawing in air, and the height or length of the chest is thereljy increased. Thus the depth, breadth and length of the chest are increased, and by muscular action. The atmosphere always pressing on everything pours into every crack or opening. The chest is an air-tight chamber, and air cannot get in between its walls and the lungs. When the ribs are raised, the diaphragm depressed and the chest thus enlarged, air enters the lungs freely through the ever-open nostrils, throat and windpipe, and they are kept stretched against the chest walls and always just fill the chamber. The walls of the chest keep the air pressure from the outside of the lungs, and so these organs are kept expanded b}'^ the air pressure on the inside of them. If an accidental opening be made through the walls of the chest, and especially if one be made on each side, as by stabs, air enters in between the chest walls and the lungs, and sometimes so com- presses them as to make breathing difficult, or quite impossible and suffocation follows. Between the walls of the chest and the lung, on each side, entirely investing the lung, is a delicate serous membrane having a double layer, one of which ITS NATURE, CAUSES AND 'PREVENTION. 25 is spread over and attacticri to the lung, forming its smooth, slippery covering, the other over the chest walls. This, like all such membranes, forms a great closed, irregular-shaped sack with the inner, opposed but unattached surfaces very smooth, and on which is a little lubricating fluid that prevents friction during the movements of the parts on each other in the acts of breathing. This membrane is called the pleura, and an inflammation of it is what is termed pleurisy. THE BREATHING ACTS AND LUNG CAPACITY. Breathing consists of two acts : first, that of raisiig the ribs, increasing the size of the chest and permit- ting air to flow into the lungs ; and, second, that of lowering the ribs, lessening the size of the chest, and forcing the air out again. The size of the chest, re- member, is increased in all dimensions — depth, breadth and length ; the ribs are raised, chiefly by the outer layer of the intercostal muscles, making the chest deeper and broader; the diaphragm is flattened or drawn down by the contraction of its fibres, making the chest longer ; and air rushes through the wind- pipe into tho lungs, keeping them pressed close to the walls of the chest. This is inspiration. The outer intercostal muscles and diaphragm now cease to con- ticict, the ribs are drawn down again, chiefly by the inner intercostals, and the diaphragm agairi rises up into the chest, helped up by the, contents of the abdomen, which are pressed upon by the muscular walls of that cavity, and the stretched lungs return to their former size again. This is expiration. We breathe 26 CONSUMPTION : I 1 ' iiiiliii ijlli m thus from fourteen to twenty times every minute; from fourteen to twenty times every minute the ribs rise and the diaphragm descends, and then both return to their former state again. The quantity of air drawn into the lungs at each breath is small when compared with the quantity they will hold. The lungs are not nearly filled to their greatest capacity, nor nearly emptied, at each breath. In a condition of full development and health, therefore, these organs have not only a sufficient breathing surface for performing their ordinary functions, but also sufficient to meet any extra de- mand, within reasonable limits, that may be made upon them. The lungs of a full-sized man will hold, when stretched to their utmost, about or over three hundred cubic inches of air. But after an or ary inspiration they actually contain only about two hundred cubic inches, remember, or two-thirds of what may be drawn into them by a forced inspiration. Now, barely one-seventh of this, on an average, or twenty-five to thirty cubic inches, is pumped in and out at each respiratory act. After an ordinary ex- piration, therefore, the lungs still contain probably one hundred and seventy -five cubic inches of air. In other words, every time we breathe we change only about one-seventh of the usual air contents of the lungs. This one seventh of the air contents of the lungs which we pump in and out with every breath is called breathing or tidal air. The quantity of air over and above the ordinary tidal air which can be drawn in by a deep or forced inspiration is called complemental II! ITS NATURE, CAUSES AND PREVENTION. air, the amount of which varies greatly in different individuals. The air remaining in the lungs after each ordinary expiration of the tidal air — that is, the other sixth-sevenths of tlie ordinary lung contents — is called stationary air. By a greatly forced ex- piration about one-half or more of this stationary air can be expelled. This is called reserve air. After tliis, after tlie greatest expiratory effort, a certain amount of air still remains in the lungs— air which cannot be expelled by any effort. This is called residual air, and its amount depends largely on the size of the chest; but it is estimated at from fifty to one hundred cubic inches. Respiratory capacity, the vital capacity of Hutchin- son, represents the quantity of air which can be ex- pelled from the lungs by the most prolonged expira- tion possible after the deepest inspiration possible. It represents the power of a person to draw air into the lun^s, and is measured by an instrument called a spirometer, into which the person breathes. The vital capacity, the quantity of air expelled, is indi- cated by the height to which the air chamber of the spirometer can be raised by the forced expiration of the experimenter. It expresses the person's breathing power in emergencies, as in active exercise, etc. The average lung capacity of a healthy adult limn, five feet seven inches in height, is about 225 cubic inches. For every inch of stature above this standard the capacity is found to average about eijht cubic inches more; and for every inch below, eight cubic inches less. The influence of weight on the ■^ 'i 28 CONSUMPTION m MM ''"■f !! iiii r ^11 !l I capacity is less manifest. It appears to decrease in weights above 160 pounds. " By age, the capacity appears to be increased from about the fifteenth to the thirty-fifth year, at the rate of five cubic inches per year ; from thirty-five to sixty-five, it diminishes at the rate of about one and a half cubic inches per year; so that the capacity of respiration of a man sixty years old would be about thirty cubic inches less than that of a man forty years old, of the same height and weight" (Hutchinson). " Bourgery cal- culates that a child of ten years of age, with a weight three times less than that of a man of eighty, has a respiratory power eight times greater, due tc the great difterence in the range of respiratory move- ments. The old man is able to increase the usual amount breathed by less than one-half, while the child may increase it nearly fourteen-fold." The capacity of the lungs, it appears, is much smaller in females than in males. The force which can be manifested by the expiratory act is, on the average, a third greater than that of the inspiratory act. There is, then, it must be remembered, usually a large amount of stationary air (reserve and residual air) in the lungs. How does the tidal air get down deep into the air chambers and reach the blood ? liiii THE BLOOD AND THE BREATH IN THE LUNGS. Gases diffuse and mix rapidly. If a jar be filled with one sort of gas and turned mouth downward over a jar filled with another sort of gas, the gases immediately commence to mingle together, and in a li i ITS NATURE, CAUSES AND PREVENTION. 29 short time both jars will be filled with the thoroug^hly mixed gases. The mixture takes place rapidly and Mtrainst gravit3^ It is constantly going on in the lungs. The tidal air we draw in at each breath (juickly mingles with the stationary air already in the lungs, and the few cubic inches of air we almost iiinnediately expel by expiration is not the same we iiad just drawn in by inspiration, but a mixtitre of tidal and stationary air : a seventh of it only, probably, being of that just breathed in. The blood in the lungs, as it moves along in the minute vessels covering the air chambers — the lung capillaries, is thus constantly bafhed with air, which is partly renewed and purified at every breath. As often as once every minute, it appears, all the blood in the body flows through the little ^'essels on the walls of the air chambers, so numerous are thev. Blood, before it passes over the air chambers, is dark purple, and is called venous blood. It has been the round of the circulation — to all parts of the body, and has taken in a lot of waste matters, chiefly in the form of carbonic acid, watery vapor and a poisonous nitro- genous substance, the carbonic acid making it dark. In this condition it flows along the veins (hence the name venous) to the heart, whence it is forced on to the hmgs. While flowing through the lungs, the blood oives off to the air in the little air chambers its l>urden of waste stuffs, and takes up from the air in the chambers a load of oxygen, and becomes again of a bright red tint — arterial blood. Thus purified an«l replenished with oxygen, it flows back to the heart, '♦1 ff -f: ^^; K I. 1 ^B i ■ t 1 ■ ill:*' I ! ! lillfii IP:;:; 30 CONSUMPTION whence it is again pumped along the arteries to all parts of the body. It now trickles through the short capillaries in the tissues into the veins once mor^ for another trip to the heart. While in the tissues it dis- charges its oxygen and is loaded with tissue waste. The oxygen in the l>lood is carried by the red color- ing matter (haemoglobin) of the red corpuscles. Magnus has shown that " venous blood contains 25 per cent, of its volume of carbonic acid, and 5 pei- cent, of oxygen ; and that arterial blood, on the otlier hand, contains as much as 10 per cent, of oxygen, and only 23 per cent, of carbonic acid." The lungs then perform a double function. They take in the oxygen which the organism requires, and which, because it is so essential to life, has been called vital air ; and they cast out a large proportion of the worn-out waste matters of the body, the prodiTcts of tissue wear and combustion, which, if retained in the blood, would soon destroy life. Furthermore, full breathing promotes the circulation of the blood, not only through the lungs but through- out the entire body, aiding in general nutrition. 'mi i m\ THE POISONS IN BREATHED AIK. Expired or breathed air contains, then, a large excess of carbonic acid and watery vapor, and perhaps most important of all, from a health standpoint, the organic poison, or leucomaine, and much less oxygen than ordinary air. While ordinary atmospheric air contains about twenty-one volumes per cent, of oxygen and .035 per cent, (about 1-30 of 1 per cent.) of I ITS NATURE, CAUSES AND PREVENTION. 31 ies to all the short mori for les it dis- iie waste, •ed color- )rpuscles. itains 25 tid 5 per , on the cent, of id." n. They lires, and een called on of the prodiTcts retained rculation hrough- lon. a large perhaps )oint, the s oxygen heric air •f oxygen cent.) of carbonic acid, expired air contains only about Ifi jier cent, of oxygen, and fully 4 per cent, of carbonic acid, or nearly 120 times as much more carbonic acid as atmospheric air. A man consumes about twelve or thirteen cubic feet of oxygen every twenty-four hours, and throws oft', by the lungs, in the same period of time, over sixteen cubic feet of carbonic acid — e((ual to about eight ounces of solid carbon — and from twenty to forty ounces of water, in the form of vapor. If a wineglassful of limewater be put in a half- pint bottle, and the breath blown two or three times into the bottle, on shaking it the limewater will become quite milky from the formation of in- soluble carbonate of lime (carbonic acid gas and lime combined), which after a little time will settle on the bottom of the bottle. Every breath contains a good deal of moisture, too, as proved when one breathes on a cold mirror. In cold weather we breathe more air and oxygen, and give off more car- bonic acid, than in warm weather, as we do likewise when taking exercise. The organic matter in expired air is a most impor- tant ingredient. It has a disagreeable smell, and is very poisonous to rebreathe. The fetid odor in unventilated bedrooms and crowded rooms is owing to this impurity. It is nitrogenous, yielding ammonia on decomposition, is but slowly oxidized, and seems to float in clouds like tobacco smoke. It is most readily absorbed by wool, feathers, and damp walls, and has been found in large quantities in the plaster m I : {m:'] I, 32 CONSUMPTION removed from the walla of hospital wards. The l>ar(' thought of inhaling, drawing into our body, tliis excrete poisonous substance from the lungs of anothei- person, or even from one's own, is very repulsive. Yet it is, with the other exhalations from the lung.s, almost co^.'Stantly and universally breathed by all classes in-doors. In the open air, or in well- venti- lated rooms, these substances are soon dissipated and rendered innoxious by free dilution with the air and by oxidation. ! Ill 11, ^mm ■ '''^li'i ' 'IP ;!il ! ' I'll" ' i i 1 I'll m illllii POISONOUS EFB'ECTS OF PUEBREATHED AIR. When the waste substances above mentioned ai't- not sufficiently thrown off by the lungs, but accumu- late in the blood, as always is the case when respira- tion is imperfectly performed, they are certain to prove highly injurious. When, for example, the air breathed contains a great excess of carbonic acid, as in the case of breathing air which has been once breathed, then the quantity of carbonic acid exhaled from the lungs is much less than usual, much of it, as well as of the poisonous organic matter, remaining in the blood. So it is likewise when the breathing acts are shallow and imperfect. The total quantit}'^ of air which flows through — that is, into and out of — the lungs of an adult person when at rest, every hour, is about 28,000 cubic inches, or 700,000 cubic inches — 400 cubic feet — in twenty-four hours: representing a cube of about seven and a half feet, or th6 full of an apartment seven and a half feet in each of its dimensions. A <i ITS NATURE, CAUSES AND PREVENTION. 33 man engaged in hard work will breathe more than double this, or an amount equal to the contents of a room ten feet square on the floor and eight high. It is found that in a room crowded with people many persons suffer from headache, dizziness and oven nausea, when the carbonic acid in the atmos- phere of the room reaches one-seventh of 1 per cent. : the effects being due doubtless to the presence of the organic vapor or effluvia from the lungs and the <liminution of ox^'gen, as well as, or more than, to tlie presence of carbonic acid. According to Parkes, wlien the carbonic acid in such an atmosphere reaches to one-half this amount, or one-fourteenth of 1 per cent., the organic effluvia is distinctly perceptible to tlie sense of smell of most persons. A man at work in a close room of the size above mentioned (ten feet by ten and eight feet high) exhaling, with every biu'ath of his one thousand breaths an hour, air con- [taining over 4 per. cent, of carbonic acid, would, [therefore, in less than one hour, render the air in the jroom so foul as to cause headache, dizziness, etc., in I many persons. From experiments of Doctor Snow upon animals, he concludes that " 5 or 6 per cent. [by volume of carbonic acid cannot exist in the air [without danger to human life, and that less than half jthis amount will soon be fatal when it is formed at [tlie expense of the oxygen of the aii-," as in respira- tion. So that a man working in such a room, if it Were absolutely "air-tight," would not be likely to survive twonty-four hours. Fortunately rooms are lever air-tight, though many persons endeavor to lake those they live in as nearly so as possibly. . i ll 1' m mm IM' \ii '1, ill* ^Mililll! 34 CONSUMPTION : THE OXYGEN IN THE BODY. The uses of all the atmospheric oxygen, as taken in by the red corpuscles — nearly a fourth part of that drawn in at every breath — is not yet positively known. Nearly all of it, however, enters into ready combination with the carbon and hydrogen of the tissues, in that tissue-change — that breaking down or " wear " (destructive metabolism)— whicl. is essential to life : protoplasm constantly being formed of the food supply going to build up again (constructive metabolism). This combination of oxygen with car- bon and hydrogen in the tissues, at the same time, produces the heat by which the body is kept warm : just as heat is produced outside the body. The pro- ducts of the combination, then, carbonic acid and water (oxygen and hydrogen), are readily conveyed to the lungs and thrown off, eventually into the outer air. Probably some of the oxygen unites directly with the carbon and hydrogen of the food. A portion doubtless acts as an oxidizer of any poisonous products in the body. It appears to act, indeed, practically as the great purifier of the organism. The distribution of non-oxygenized blood over the body is " incompatible with life for more than a few minutes ; the rapidity with which death ensues in asphyxia being due, more particularly, to the effect of | non-oxygenized blood on the medulla oblongata, and, through the coronary arteries, on the muscular sub- stances of the heart. The excitability of both nerv- ous and muscular tissue is dependent on a constant | and large supply of oxygen, and when this is inter- ' ' I ITS NATURE, CAUSES AND PREVENTION. 35 fered with, is rapidly lost. The diminution of oxygen luis a more direct influence in the production of the usual symptoms of asphyxia (suffocation) than the increased amount of carbonic acid " (Kirk's Phys.). THE FOLLOWING! IMPORTANT FACTS may be summarized here with advantage. Our habits of life, our daily practice, should be in accordance witli them. Air once breathed contains nearly a- fourth less oxvj^en than atmospheric air, and hence is quite inadecjuate for the purposes of respiration — unfitted to l)e breathed again, or to sustain life. Out of doors, in the momentary pause after expira- tion, the air just exhaled is usually at once changed — renewed, before another breath is taken. In very calm, "close" weather, fans are instinctively used in a measure for dissipating the breath. Air once breathed contains, besides the poisonous organic effluvia and much moisture, above 4 per cent, of carbonic acid, or 120 times as much as pure atmospheric air. When respiration is not perfectly performed — when the air breathed is not pure, or the lungs are not habitually fully distended and used — poisonous waste matters are retained and accumulate in the blood, I causing derangement and disease. It will now be easy for the reader to understand [how very essential it is that only pure, fresh air be breathed, and that it be breathed not sparingly ; how essential, for both dwelling-places and the lungs, is free ventilation. if I *, i I.! 1! i '■; IPI, ■' III I(! ■';!!lll|)| iiii' . l:;; iliii 36 CONSUMITION : PROPORTIONATE CHEST DIMENSIONS. For perfect respiration, well -developed lunj^s, of a si/e proportionate to that of the other organs of the body, are indispensahle, and the lun^s must be exer- cised and used in a rational manner. Many persons with well-developed lun^^s do not use them as they should — fully and freely. In the structure of almost everyone there is, from hereditary and other influences, a want, small or j^reater, of due I'elative proportion in the various ort(ans of the body, some organs not being so well developed as others. It may be the stomach, or the heart, the lungs or the brain, which is defective, and hence the weaker organ. It is very desirable foi* every person to know the weaker parts. As regards tlie lungs, the dimensions given in the following table show the circumference of the chest of well-developed, vigorous persons of the respective height and weight given. The size of the chest fur- nishes a correct index of the size of the lungs, as these organs with the heart and its large vessels just fill this cavity. HKIOHT CIRCUMFKRENOE OF CHEST ON AVERACJE OF INDIVIDUAL. A LEVEL WITH NIFPLE. WEIGHT. MEDIUM. MAXIMl'M. 5 feet 1 ill •lies 34.06 inches 40.66 i aches 120 lbs. 5 II 2 11 35.13 II 41.33 II 125 1, 5 ,. a n 35 70 It 42.00 II 130 II 5 II 4 36.26 II 42.66 II 135 1. 5 II 5 II 36.83 II 43.33 II 140 1. 5 II 6 II 37.50 II 44.00 II 143 .. 5 11 7 II 38.16 II .44.66 II 145 .1 5 1, 8 II 38.53 i< 45.33 II 148 11 5 1, 9 H 3H.10 II 46.00 II 155 .1 5 .. 10 II 39.66 II 46.66 II 160 .. .5 M 11 II 40.23 II 47.33 II 165 .1 a .. • 1 40.80 II. 48.00 II 170 M I i.i.l:, ITS NATURE. CAt\SKS AND PHFVENTION. 37 With fho lungs proportionorl al)oiit as above indi- cated, liabitunlly exercised to the full re(|uirements of tlu' hody, and takin^^ in only fresh, pure air. tlie function of respiration is almost certain to he per- fectly performed, and consumption ])re> ented. Tllfc I.lJN(iS MAY BE ENLAHCiED. It nuist not be supposed that for persons l)orn with pi-oportionately small lungs then; is no remedy. The .size of the chest and lungs may b<? very materially increased, just as an extrenuty, the arm or leg, may be increased by judicious exercise. Imperfect respiratory action is very common. The movements of the lungs an«l walls of the chest have their origin in, and are controlled by, nervous influence. Breathing is not a voluntary, but an involuntary act. We breathe witbout knowing it ; but breathe we must. We can breathe (juicker or slower, take long breaths or short ones, but we can- not by any unaided effort of the will stop the l>reath- ing. B^rom imperfect nervous developmtuit, however, or derangement of the nervous system, from habit or want of active exercise, many persons do not com- monly, perhaps never, fill and distend their lungs to the full requisite extent. In such circumstances, not only is the whole function of respiration imperfectly performed, but the almost unused parts of the lungs, the distant parts — the extreme upper edges, or Jipexes, espec'ally — become weakened and eventually diseased, as any part of the body, an arm, for example, would, if it were not used for a long time. Consump- tion usually commences in the apexes. The remedy is obvious, and in the hands of the persons themselves. t»i I i n '!• '^i (pi;, i- '""iiiiiih !"iiiii'iii' »! Illii 38 CONSUMPTION : CHAPTER III. NATURE AND CHARACTERISTICS OF TUBER CULAR PULMONARY CONSUMPTION. WHAT IS CONSUMPTION? ITS DIFFERENT FORMS AND NAMES. Consumption is particularly characterized by the formation in the lungs of what is called tubercular matter, or "tubercles," with destruction or wasting of the lung tissues, usually with insidious conimencf- ment and slow progress. The disease has been known by different names. In the human body it has been long commonly called consumption — wasting, "pining" or "decline." In the lower animals it has been known as the " grapes ' or " pearl disease," and sometimes the animal has been called a " waster." The diseased conditions long recognized by these various names and believed to be different are now known to be one and the same. Three forms of pulmonary consumption are some- times described by authors — the catarrhal, the fibroid and the tubercular, apparently in accordance with the respective feature which is most predominant; whether more catarrhal in character, or more fibrous, or more abundantly tuberculous. At any rate, the catarrhal and fibrous forms are not common, and in ill . I ■r:iiill|lll liiti llliirl ITS NATURE, CAUSES AND PREVENTION. 39 the earlier stages, appear to be usually but diseased states of the lung tissues of a non-specific character, by which the tissues are brought into a condition more suitable for the growth of the characteristic formation — tlie tubercle — of true tubercular pulmon- ary consumption. There are occasional cases of the fibroid form in which, from an excessive formation in the lungs of fibrous tissue, these organs become more or less solidified and their functions proportionately destroyed, and in which the symptoms resemble those of the true tubercular disease, but in which no tubercles are found. Some authorities contend that these are not tuberculous. One of the best of them, however, R. Douglas Powell, M.D. (iEtiol. of Phth.: Dis. of the Lungs), has quite recently written, — " Further experi- ence has led me strongly to doubt whether in all cases of fibroid phthisis tubercle does not tp.ke an essential part." Practically, the catarrhal and fibroid forms need not be further noticed here. • 3 1 WHAT IS TUBERCLE ? Now, w^hat is this peculiar substance, tubercle ? When first or recently formed in the body tissues, or as found resting sessile on tissue, often " standing out distinctly," it is a little pearl- like mass, usually rounded where separated from others, and varying in size from a minute speck to that of a small shot. It is somewhat sticky, tough, and difficult to crush or tear. At fi»;t it is greyish-white and semi-transparent, but later it becomes slightly yellowish and opaque. These little IrW I; ' It ' .':'iH','\ ilii'f'i'i 40 CONSt^MPTION : masses, especially wlien numerous and scattered, from being usually about the size of a millet seed. have been called " miliary tubercle." By their pearly appearance, the name " pearl disease," in bovine animals, was suggested. Sometimes a number of these little tubercles are found in a cluster. Masses the size of a walnut or larger are often formed by the aggregation of the smaller ones. So numerous and enlarged do these growths sometimes become in bovine animals that the lungs are thereby increased to thrice or even five times their natural weight, to from forty and even sixty pounds. Tubercle has never been found except in warm-blooded animals. THE TUHERCLE BACILLUS. What is the cause of the formation of tubercle ( Whence comes it ? For thousands of years these questions could not be answered. For only about half a century now it has been known that tubercle could be newly developed in certain susceptible ani- mals by inoculating them with tubercular matter w^hich had developed in another animal. It appears that Buhl, in 1857, demonstrated the fact that it was invariably due to the existence of it or its products in some other part of the body ; and Villemen, in 1865, made its specific nature still more conclusive by repeatedly producing tubercles in unaflfected animals by inoculating them with tubercular matter. It was only in 1882, however, that Doctor Robert Koch clearly demonstrated that one immediate, essential and what is now usually regarded as the directly exciting rniise o MMt I ri;ii|llilllil|l iiiiiiiiii''iH;i ITS NATURE. CAUSES AND PREVENTION. 41 cause of the tubercle formation is a living microscopic iunmis. akin to those which form moulds and to the {jerms of other infectious diseases, a species of bacillus (Latin, haculum : Greek, baktron : a stick or .staff"), and a variety of bacterium. It is a "parasitic" (so-called) vegetal organism of the lowest or simplest form of life, now termed the hacilliis tuherrulosis (bacillus of tubercle or tubercle bacillus; in the plural, bacilli), or bacillus of Koch. Each bacillus is from 1-12,000 to 1-8,000 of an inch in length, less than half tlie diameter of a red blood-corpuscle, or blood-cell, with a thickness of about one-fifth or one-fourth of its length. It is usually slightly curved or bent, with somewhat rounded ends. Jt has no motion, and is said to exist " better where there is no oxygen " — Facultative anaerobic (M. V. Ball, M.D.: Essent. of Bact. ). At a temperature of 86° F. it grows, it ap- pears, but slowly : and it will not continue to pro- pagate in decomposing fluids or in the presence of bacteria of more rapid or more vigorous growth (in the laboratory). By direct sunlight its vitality has boen apparently destroyed in two or three hours, while it is destroyed in a few minutes by a moist temperature of 128° F. In a dry state, however, as in sjnitum or spittle, its vitality may be preserved for months. fi- ,1 LABORATORY CULTIVATION OF THE BACILLUS. Although tubercle cannot develop except in a warm- blooded animal, living cells being essential for its development, the tubercle bacillus can be cultivated fn h: m llipi'ri' "llli I'Mi li 42 CONSUMPTION : in the laboratory. If a little of the serum (the watery part) of ox-blood or other certain prepared liquid be placed in a test tube (a long, narrow sort of bottle of thin glass), and sterilized by heat to destroy any bacteria it may contain, the mouth of the tube being plugged with sterilized cotton wool to strain the air and keep out other bacteria, and if when the culture material — the seruia — becomes solid, a minute particle of fresh tubercular matter be carefully placed on it, and the whole kept at blood temperature, or about 100° F., in twelve or fifteen days there may be seen around the tubercular matter a few minute, very thin, lustreless, greyish-white, scale-like particles. These consist of colonies of the tubercle bacillus, which had grown there from germs in the particle of tubercle planted. Under the microscope they are seen t be composed of " many very fine lines containing the bacilli." The mass " sometimes looks like crumbs of bread moistened." A Klatsch preparation under the microscope shows " a thick, curled-up centre, around which threads are wound in all directions, the fine lines showing the bacilli in profusion " (Ball). Again, if a little bit of one of these scaly particles be selected and placed on a culture material in another test tube and treated in the same way as the first, in another twelve or fifteen days numerous scale-like colonies of bacilli will have again grown up around the planted " seed." After repeating this transplanting process a hundred times — cultivating a liundred generations — the bacilli not only preserve their char- acteristics, but a purer cultivation or quality i6 .() i'!i i'i1lllill!l|i| niiiiiiiiiiiii! ITS NATURK, CAUSES AND PREVENTION. 43 obtained. They can be cultivaterl in air-tij^lit tubes on sliced potato. Wlien ])ure bacilli are inoculated into the body of a .susceptible animal, tubercles form in it, Vieginning their growth at the point of inoculation, .spreading along the cour.se of the lymphatic vessels, and cau.sing the characteristic symptoms of tubercular disease. The same result follows when the animal is inocu- lated with a particle of tubercular matter from the expectoration or spittle of a consumptive person, in which the b icilli usually exist in great abundance ; and, also, as sometimes unfortunately happens, when a linger is accidentally wounded, and so inoculated, in making a pusf -mortem examination of a tuberculous l)0(lv of either man or one of the lower animals. 1^ SPOKING AND MULTIPLICATION. Under a high magnifying power, the tubercle bacillus .sometimes presents to the v^ew oval sjmces at intervals within the rod, giving a dotted or beaded apj)earance, indicating the production of, or breaking up into, spores ; after the manner of moulds and messes : by which, it need hardly be said, these low forms of vegetation multiply themselves, and also resist influences, such as heat and cold, which destroy tlie parent plant. That this bacillus is a sporing organism, although not (juite satisfactorily established under the microscope, can hardly be doubted. In order to perpetuate itself it must, it would seem, pro- duce some smaller, more resistant bodies, practically spores — something analogous to or corresponding WTF" 44 CONSUMPTION 'M I ! ! mM\ ■1,1 with the seeds of the higher plants. According to Solles and others, if a rabbit be inoculated with a portion of an old, non-progressing, dried-up mass of tubercle, as from the apex of the lung of a person who had had consumption and was practically cured, and in which no bacilli can be found, the animal will probably die of tuberculosis, and in the tubercles formed in it, numerous bacilli mav be found. The bacilli had dried up and disappeared from the tuber- cular mass used for inoculation, but left, evidently, their seeds or spores. Doctor Douglas Powell (as be- fore cited) says, " It is difficult to escape the conclu- sion" that such matter contains " abundant tubercular 3p'i .*, as yet undeveloped and unrecognizable." The bacillus multiplies also by division, or fission, — a mr^hod ">^ asexual reproduction common amongst these low organisms. Each bacillus undergoes cleavage crosswise into two equal parts, which then become two independent organisms. That spores are more difficult to destroy by disinfection than the parent plant is an important point to bear in mind in the practice of preventive measures. RELATIONS OF THE BACILLUS TO THE DISEASE. Very few authorities now question the correctness of what is termed Koch's theory : — that without the tubercle bacillus there is no true tubercular matter. But it is not yet clearly known whether the peculiar symptoms, local and general, of tubercular or con- sumptive diseases are caused simply by (1) the con- stant irritation set up by the local growth and multi- ITS NATURE, CAUSES AND PREVENTION. 45 plication of the bacilli in their parasitic or saprophy- tic life, a local inflammatory action ; or whether they are caused Vjy (2) the formation or excretion by or from the micro-organism of a substance having a jioisonous efiect upon the tissues invaded : or whether by (•^) the microbes causing in their life action such cht'inical changes or fermentations in the tissues or thii<ls as to give rise in this way to a poison, causing, ill either case, toxic effects upon the entire body. Possibly the symptoms are caused in a measure by each and all of tlie three ways. It is known that the hacilli, in certain conditions, do give rise to a poison- ous product. The constant local inflannnatory action set up simply by the presence and multiplication of tile micro-organism, as a foreign body, however, \vould seem to be enough to cause the symptoms in the previously deranged and depressed, if not diseased, l)o(ly of the host. However the symptoms may be produced, it seems to be generally believed by the highest authorities that a case of tubercular disease, or consumption, of any kind, will not develop without this bacillus or its spores, any more than a stalk of wheat or corn will spring up without the seed or germ-grain in the soil. Doctor Jane way, of New York, says (Discuss. N.Y. Acad, of Med., Jan. '91), " There are to-day only a few physicians who hesitate to accept the bacillus tuberculosis as the direct exciting cause of tubercular phthisis." And Doctor J. West Roosevelt (Phys. Roosevelt and Bellev. Hosp. N.Y., at ann. meet. Assoc. Am. Phys.) says, " There is no need at this time and !'i "riiiil ^ CONSUMPTION in the presence of this audience to state that, without the presence of Koch's bacilhis, there is no tubercu- losis. Possibly the statement that without tubercu- losis there is no phthisis nii^ht not yet be so gener- ally admitted, though it is probably true. . . . Con- sumption, whether called ' catarrhal ' or ' tubercular phthisis ' or by any other name, has as part of its lesion [diseased condition] newly formed tissue containing the bacillus tuberculosis of Koch." WHENCE COMES THE TUBEUCLE BACILLUS ? The special characteristic feature then of consump- tion is the growth or formation in the lungs of a peculiar substance called tubercle, an absolutely essen-- tial factor in the formation of which, or an essential cause of which, is the tubercle bacillus. Now whence, it may be here asked, comes this bacillus ? As above observed, it ei.ists in abundance in the expectorated matter from the lungs of consumptive persons, and it can be cultivated in the laboratory. Koch's view appears still to be that it is a " true parasite " and cannot live outside the body of its host ; and that it will thrive and multiply only at a temperature ranging from about 95^ to 105° F. Hence it is inferred that it can only come from another case of the disease in man or the lower animals. It is to be regretted that the more natural or botanical charac- teristic features of this bacillus, as well as of other disease germs, indeed, have not been more specially and deeply studied, along with its laboratory or other characteristics. It seems possible that it may flourish 111 liiiililiii ITS NATURE, CAUSES AND PREVENTION. 47 outside a living animal body, and may be akin to ao- called " malarial " (n-ganisms. It is well known that otlicr germs — as the bacillus of " splenic fever," for example, in its natural state — flourish and " complete tlieir developmental cycle," as Koch words it, outside the body, and only at times, in certain conditions, invade it and become of a parasitic oi* disease-pro- ducing — pathogenic — character ; as prolably too do the germs of typhoid (or enteric) fever and of cholera, and, it ma}^ be, of diphtheria. Ill 1801, Sir Hugh Beevor, it appears (at Patholog. Soc, London, Jan. 10th : Lancet), demonstrated that tlie tubercle bacillus can be cultivated at a temperature Ik'Iow 60° F., that of ordinary summer weather. In a book on the " Prevention of Consumption," pub- lished a few years ago, and later in communications to the Lancet, Mr. C. Chandler, of Melbourne, Aus., contends that the microbe in some form or phase ^a'ows " free in nature," in dark places : especially, he l)elieves, in dark, foul bedrooms. This is an exceed- in f^ly important (piestion. Further on, in considering the causes of consumption, it will Ije again discussed. At the present time we only know of a certainty that the source of the bacillus is from a case of consumption. SAPROPHYTES AND PARASITES. There are many spe< ies of •small plants, such as most fungi (with which have been classed most of the disease germs), called saprophytes (from the Greek, sapros, rotten), the nature of which is to grow and flourish only or most naturally on dead organic :M1 ffir 48 CONSUMPTION : !'■' .. w i I! n V i 'liiiiai'iiiii :i II .. w !iiii!||jiij.|jj,| ih matter. This is the case, as we know, with some of the larger forms, such as mushrooms and sonif moulds. Now, it is possible, even probable, that all, the disease-producing bacteria, such as the b'^cillus of tubercle and of typhoid and other fevers, are natur- ally of this sort, saprophytic, and in their naturul state live and flourish only or best in, or in association with, some form of dead matter, either within a livinj; body or free in the outer atmosphere. It is impro- bable that a parasitic, disease-producing life is natural to these micro-organisms, but rather an accidental or acjpiired state. Indeed, it seems highly probable that they are rendered virulent and disease-producing l»y insanitary conditions. Evidence of their transforma- tion from a saprophytic to a parasitic life accumu- lates with investigations. In respect to parasitic diseases of the skin and hair, for example, Leslio Roberts, M.D. (R. Infirm., Liverpool, Eng.: Brit. M('<1, Jr.), in a paper read at last year's meeting of the Brit- ish Medical Association, gave the following valual)lt' and suggestive information : " I cannot see how it i^ possible to avoid the conclusion that the hair-attackin^^ fungi belong essentially to the saprophytes, and to that class of saprophytes which may, under certain condi- tions, adopt the parasitic life. The search for the via naturae of these fungi, by which they ascend to their parasitic position on iftan, may be hopefully under- taken." Again, Doctor Roberts says, " We have seen that without any change in its saprophytic habitat the fungus may pass from an inert vegetable soil to animal tissue or hair." Respecting certain experi- r iiients, li of a den vcgctabl nanu'ly, A dis parasitic organic former ai tlu! lattei of their niicro-ori pathogen organism parasites define. ''. e.xist and I u})on the obtainiuir used-up, c |ous funct Itody in.sti excretory I in a living phytic as I the organ] [so-called j [nature of [thrive in ( In cert [plained in jisms may 4 \^\■ ■■' 'i'li ITS NATURE, CAUSES AND PREVENTION. 49 ineiits, ho said, " They point, I think, witli the force of a (k'lnonstration, to a .source of rinj^worni and other vo;,^('tabIe parasitic diseases hitherto scarcely suspected, namely, dead organic matter." A distinction is made between saprophytic and parasitic micro-organisms ; the former living on dead organic matter, the latter on living bodies. The former are benign organisms — scavengei's, so to speak ; the; latter feed upon the fluids or tissues of the body of their host, and may hence cause disease. When micro-oriranisms cause disease th«'V are then called pathogones (Greek, pathos, disease), or pathogenic organisms. The distinction between saprophytes and parasites is, however, difficult to clearly n)ake out or define. These most minute forms of plant life may exist and propagate in living bodies without feeding upon the living fluids or tissues therein, but instead, obtaining their nourishment from any excess of the used-up, eftete, dead products resulting from the vari- lous functions and processes of life, retained in the l)ody instead of being thrown off by healthy acting j excretory organs. Existing in this w^ay, on such food, I in a living body, such microbes are as strictly sapro- ipliytic as if living in or upon a dead Ijody. Many of the organisms living in the human intestines, even the so-called parasitic worms, are doubtless more of the nature of saprophytes than parasites, as they do not [tln-ive in a clean, healthy intestine. In certain body conditions, which wi- b^ ex- Iplained in future pages, saprophytic or benign organ- jisms may become disease-producing or pathogenic. 50 CONSUMPTION : To pfivo a HiMiplc illuHtration, — a inicrococcuH natur- ally un«l coiiunuiily present in the .saliva of liealtliy human b(!ings, in certain conditions oi' certain persons, is so virulent as to cause tlie death (if rahbits when the saliva is injected luider their skin. The saliva is quite harmless when the cocci are taken from it. It has been .suggested tliatasuperabundai*"*' of the fluid may be the cause of the poisonous are of the microbe in it, but this is probably, at most, a remote cause. The excess of saliva may give rl.se to some special con<lition which renders the micrococcus poi.sonous. It is still a ([uestion with .some hifj;h authoritic whether the tubercle bacillu.s ever jijrows and propa- gates in healthy living Ijody tissues, or, which .seems much the more probable, only in altered or diseascil, practically partly dead tissue — tissue containing elo- ments of dead matter. 4 TUBERCLE IN OTHER TISSUES AND aNIMALS. Other tissues besides the lungs, as alrea<ly stated, are often the seat of tubercular growths. The intes- tines, the liver, spleen, kidneys and other glandular organs, the brain membranes, the skin and the bones are subject to the disease. The muscles (flesh) are but rarely invaded. As the tubercle increases, the affected tissues gradually " waste away " and are replaced by the disease product, which, too, eventually dies and disappears or dries into a hardened lime-like mass At the same time there is usually a general wastin; of all the tissues, We have therefore tuberculosis or ITS NATT'RK, CAl'SES AM) PHEVENTIOX. 51 in conHumption of many parts of tlie body. Next fn'(|uency to the lung affection is " con8Uinptit)n of the l)o\vel.s," chiefly characterized Viy a tubercular dcHtruc- tion or wasting of the glands along the course of the intestines. This is more especially common in young children, and is believed to be frequently caused by the use as food of the milk of tuberculous cows. Many of the lower animals ai*e also subject to this disease. Bovines appear to be moreso than any others. It is common in poultry, pigeons and other birds. Horses, pigs, sheep, cats and dogs are less disposed to it. Rabbits, monkeys, and all menagerie animals kept caged or housed are very liable to the disease ; indeed, it is the principal cause of death amongst these animals. Crisp, it is said, has met with tuber- jculosis in over one hundred difF» rent species of ani- jmals, including reptiles. It is very rare, if not quite [unknown, in animals in a wild state. This indicates |a (rood deal bearing upon the cause and prevention of the disease. SIMPLE EXAMPLES OF PARASITIC DISEASES. As a simple illustration of parasitic diseases, it will )e interesting and instructive to briefly notice here |in affection formerly believed to be tuberculosis, now technically termed actinomycosis, more commonly Luown in cattle as "lumpy jaw." It is an infec- ious disease, common in bovine animals living on ret soils, as the fen districts of Scotland, and is not Uncommon on this continent. It is caused by the I'owth and multiplication in the tissues of the animal «.'! ■ 52 CONSUMPTION hll'!' ■iiiii \1,I0 > 'I- ^ i of a star-shaped fungiis ; hence the name, Tliis exists in abscesses formed near the jaw during the course of the disease, and commonly in the form of minute granuhir masses, or little grains, the larger of which can be seen with the unaided eye. Colonies of the organism, even with slight magnification, present to the eye a radiate pattern, and with a higher power, the centre resembles tlie heart of a daisy. Accord- ing to Jensen, it grows on grain husks or straw. Many cases of the disease in the human body have been recorded. Saltmann reported a case in a boy which was caused by swallowing an awn of barley, An abscess formed near the throat in which was discovered the ray fungus. Another example is the thrush or " white mouth,' of young infants, especially of those who are hand- fed, and in badly nourished adults. It is caused by aj parasitic fungus, oldiuin (dbicanns, and occurs in two forms : hypha^ (a web) and threads of spores. i)\\\ cut potato it develops into thick white colonies Injecte<l into the veins of rabbits it causes their deatli in one or two days, ihe inner organs being tilled] with the hyphne. This fungus is " specifically iden- tical with sarcharomyces ijiycodenn a, or 'flowers ofj wine,' a ferment developed on the surface of liquidsj which are acid and contain little sugar " (Trouessartlj FORMATION AND PROGRESS OF TUBERCLE. The local changes and conditions in the body tissiicl of the consumptive, and the general progress amlf symptoms of the disease, vary with the con8titutioii| ITS NATURE, CAUSES AND PllEVENTlON. 53 iUid eoiulition of the individual afiV'cted, chii'Hy, and ill a ineasurc with tlieWirulency or jxHsonous char- acter (wliicli varies witli certain circumstances) of the tuljercle baciUus. Into tlie hm^s the bacilli j^ain ucct.'ss by being drawn in with tlie air in l>reathin^. When they lodge there, it is usually, first, in the miiuite bronchial tubules which open «lirectly into the air chambers. Infection, it aj)pears, usually c(jm- iiieuces there. If the tissue condition be favorable, tlie soil suitable, and the bacilli be not too greatly attenuated (weakened), they " take root," a colony of tliem forms eventually, and a minute tubercle results. The manner of formation of tubercle is highly interesting. In order to understand it one must bear ill mind that the bacilli are exceedingly minute. One of the large white blood-corpuscles, — soft, jelly-like cells, penetrates the wall of a lung capillary, usually, and, as it were, sucks the newly arrived invading bacillus into itself with the purpose of digesting or destroying it ; a process to be noticed further on. The corpuscle then becomes larger, the bacillus in it multiplies, other cells are attracted to, and join it, and a tubercle ^is there formed. A newly formed primitive tubercle consists of numerous small round cell!- packed together with a large or " giant cell," sciiiietimes two, at the centre, while within the cells to some extent, and more abundantly between them, [are the bacilli. From lack of nourishment, as no j blood vessels form in it and no blood can enter, and it niay be, too, from the effects of a poison produced by (the bacilli, destructive changes soon commence in the i 54 CONSUMPTION |i I centre of the tubercle, and extend till the whole degeneration into, or becomes, a mass of yellowish, fatty granules resembling cheese, and is said to be cheesy, or caseous. In this disK jlution of the tubercle the bacilli usually disappear, probably leaving, how- ever, a crop of living spores. The time reijuired for the development of tubercle and its degeneration or decay is very variable. In the more chronic cases of the disease the little masses form slowly, and remain small and few in number for a long time, months and even years, degenerating slowly, too ; while in ate cases they may reach the size of a pea in three or four weeks. Whe^, the subject of them presents a particularly favorable soil, or when the bacilli are, or become, very virulent, tubercles form rapidly and in large numbers throughout both lungs, sometimes giving rise to rapid exhaustion, much difficulty in breathing and early death. i ANTAGONISTIC BODY FORCES. As intimated above, and as will be explained more at length in another section, certain cells or corpuscles in the blood resist and endeavor to destroy and cast out disease germs ; indeed, this is their action with any foreign substance whatever which has gained an entrance into any part of the body, as we find to be the case after the minutest thistle point has pene- trated the cuticle and gone far enough into the true skin to cause pain or irritation. Moreover, in indi- viduals in good health there appears to be in the ITS NATURE, CAUSES AND PREVENTION. 00 blood serum a germicidal or antidotal substance which is detrimental to the life of such foreign bodies as disease germs in the tissues. However this may he, tubercle, and indeed the whole disease process, and its products, in consumption, appear to be the direct result of a warfare for supremacy l^etween the invading bacilli on the one side, and the protective bodily forces on the other, and in which the latter have been unable, from some cause, to successfully compete with and destroy the bacilli. The contest goes on. Too often the invaders maintain their posi- tions, while they continue to gain new ones, increas- ing the tubercular formations and xtending their depredations ; and so the disease progresses. The minute tubercles formed coalesce and give rise to clusters of them or larger masses of irregular shape ; air chambers become blocked up and their walls thickened, until at length portions of the soft, spongy lung tissue are replaced by masses of tubercle. THE CHANGES ARE INFLAMMATORY. The local disease process is really all through of an inflammatory, conservative character ; indeed, a series of circumscribed points of inflammation set up by the bacilli, varying in degree and extent like the tuber- cular deposits — chronic or more acute, limited or more extensive — depending on, or according to, the constitution and condition of the subject or body aftected, and the virulence of the bacilli. When a prickle from a thistle is forced into the skin, a pro- cess of inflammation is set up at the point and around n 56 CONSUMPTION ! v:< i lln:';. •:!• li! it, by means of which the prickle is eventually forced out. A fester commonly forms in cases of this kind, and along with the pus or " matter " discharged from it the offending prickle is thrown out. In some good constitutions we find the foreign particle is removed more naturally, or kindly, or with less irrita- tion or pain, and in a short 'r period of time, than in other constitutions, in which the process is more pain- ful and tedious. Somewhat so it is with the bacilli in the lung tissue. In a susceptible body — in a person strongly predisposed to consumption, with impuie, defective blood and other fluids, and consecjuent weakened tissues and blood cells, the bacilli, when they chance to be breathed in sufficient numbers into the lungs, And there an attractive field — abundance of suitable food — and make easy conquests, while they take on a more virulent character. The army of weakened blood cells or other protective forces can offer but little resistance. The inflammation sot up is consequently of a low scrofulous form, against which the invaders make easy advances. On the other hand, when the little plant-rods, however viru- lent, find a resting-place on the mucous membrane of the minute terminal bronchial tubes of a well-cared- for healthy body, with good pure blood, a germicidal intoxicant and an army of vigorous protective cells, if the invaders be not carried out at once and first by the cilia on the mucous surface of the tubes (page 23), they are soon attacked by the blood cells: a "rush of blood" with more cells, if called for, now flows to the spot, and the process we term inflammation, ITS NATURE, CAUSES AND PREVENTION. of tlic simplest kind, is sot up and the unwelcunie intruders are probably in due time satisfactorily dis- jioscd of, perhaps without the complete formation of tubercle at all. Possibly they may be then thrown out of tlie lung along with mucus, more or less thickened, by a slight cough. Indeed, it seems pos- sible that many p >rsons may at one time or another (hiring life, or perhaps from time to time, and often, breathe in these bacilli (which are almost ubitjuitous, tVoni being spread about by the coughing and indis- eriuiinate spitting of consumptives) and dispose of them in this way, the whole process or act seeming to be but the result of a " little cold." In some cases — in certain constitutions or condi- tions — after a mass of tubercle has been formed in a lung, and after the individual has been brought into a more healthy, vigorous condition, as by medical treatment or a change to healthier living, then by a more vigorous, local inflammatory process, a strong wall of fibrous tissue is built up completely surround- in;^ the tubercle, cutting it oft" securely and per- manently from the body tissues and rendering it iiitirely harmless. In this way other foreign bodies 1 or growths, as a leaden bullet, for example, is some- j times disposed of by the natural powers of a healthy vigorous body. One great difference between the effects of the [tubercle bacillus and the prickle of a thistle or other dead particle in the tissues is that, in the former case, [by reason of the cause of the inflammatory action having life and power of multiplication, there is, if I'. 58 CONSUMPTION the living microbes be not at once cast out or de- stroyed, a constant succession of new irritated points or causes of inflammation that will eventually wear out, exhaust and destroy the life of, the invaded body. Again, the bacillus is usually of a much more poison- ous, irritating nature than the thistle point. 'i..=:«i DIFFUSION OF TUBERCLE IN THE LUNGS. If, then, on the first lodgement of virulent bacilli in a lung they be not at once cast out by the cilia or soon destroyed or enwalled by the protective germi- cidal powers of the body invaded, they multiply and form new centres of colonization and inflammation. They first, we will sp^^ lodge and colonize, or " take root," in the upper part or apex of a lung ; tubercle is formed there, which eventually undergoes degen- eration, softens, and particles of the softened, cheesy matter, perhaps sometimes still containing living bacilli, or, if not, their spores — it may be both — are conveyed by the cilia on the mucous surfaces toward the larger bronchial tubes to be coughed up; in their passage, the cilia not being vigorous in action, perhaps broken down and destroyed in places, the germs find lodgement in other and new points, where more tubercle is formed, which likewise softens and spreads in like manner. Unless this development of new tubercle be stopped, gradually more and more lung tissue becomes involved in the inflammatory process and its worst consequences, and the function of perhaps the entire lung is destroyed. Particles of tubercular matter probably sooner or later find their WW ITS NATURE, CAUSES AND PREVENTION. 59 way into the other hing, and eventually large portions of both lungs become involved. FURTHER DISEASED CONDITIONS. During the progress of the disease it is very com- mon for the inflammatory action to extend from the lungs to the pleura, especially to the visceral layer closely investing the lungs, and for the two opposed, touching surfaces of this smooth, lubricated mem- brane (page 25) to become much thickened and grown or " glued " together by the diseased action set up. A portion of the lung is then bound down to the wall of the chest and its action much limited. It is, too, tlie inflammation of tlie pleura — pleurisy — which in nearly all cases of consumption causes the pain, more or less of which is commonly experienced in the chest during the course of the disease. Again, the larger tubercular masses formed in the lungs, perhaps after protective bodily efforts had con- structed a fibrous wall partly around them — in such cases almost a fruitless effort — degenerate and dis- charge their contents, as the smaller tubercles do, as above stated, and the partial wall remaining, what is called a "cavity" is formed in the lungs : it is a place where a tubercle had developed, destroyed the lung tissue, and then itself degenerated and wasted away. In advanced stages of the disease it is common to find cavities in the lungs formed in this way, varying in size from that of a walnut to that of an orange, more or less irregular in shape, containing only air. In favorable ca^es, a cavity may become quiescent !•♦! i :■■! H i • \: m I'/ 60 CONSUMPTION : 11 li , ll -.o li .i '■:!;!! I ll!l,ll|jilsl i!!ii and very jri-aJually contract and close its vvnlls together, or tliis may take place in a short time. In either case, eventually, only a cicatrix, or scar, is left. In less favorable cases the cavity may con- tinue for a long time, perhaps many years, to secrete and give off from its walls a creamy pus—" matter.' And again, from defective inllanimatory action, ulcers form in the walls of the bronchial tubes, which remain open, and pus is discharged therefrom Suppuration in this way is common. And yet again, gangrene — mortification — of a por- tion of the lung may take place, the blood supply having been cut off in some way. In a few constitutions in which the progress of the disease is very slow, from the formation of an excess of fibrous tissue substance, as if intended, but not used, for encapsuling — constructing a protective wall around — a tubercle or tubercles, air chambers are, as it were, glued together, and the entire lung becoiius less spongy and more dense : finally a large portion of it may become contracted and solid — fibroid phthisis (some authorities, as already stated, believing this may occur without tubercle or the tubercle bacillus). Occasionally an entire lung becomes solid ified in this way and quite inactive and useless for respiratory purposes. It is then commonly said that the lung is " gone." Entire collapse of clusters of air chambers — lobules— of the lung may result from the blocking up of bronchial tubules. All these conditions are sometimes found in the m lungs of brought part of tl invaders. tween th sufferer f less iiiyi microbes other pro Too often local disef the entire mined an from cons We maj brighter si at almost general coi are not yei able hope < cation of tissue be It forces, by ] individual the lungs established applied as the microb( ITS NATURE, CAUSES AND PREVENTION. 61 \nu(fs of a person who lia<l died of coiiHuinption, all brought about by fruitless protective efforts on the part of the invaded body to check the progress of the invaders. We can imagine the contest going on be- tween the two forces in the lungs of an unfortunate sufferer from this dread disease — between the count- less myriads of infinitesimal and now virulent microbes on the one side, and the blood cells and other protective or antidotal forces on the other. Too often, alas, the countless myriads conquer. The local disease becomes more and more extensive, and the entire constitutional forces more and more under- mined and exhausted, until finally one more death from consumption terminates the struggle. the THE BRIGHTER SIDE. We may here look mentally for a moment at the brighter side — at a case terminating in recovery. If at almost any stage of the local disease, while the general constitutional forces of the affected individual are not yet too far undermined, there may be reason- able hope of a practical, permanent cure by the appli- cation of proper remedies. If enough sound lung tissue be left on which to build up the natural body forces, by pure air and other remedies suited to the individual case, the depredations of the microbes in the lungs may be arrested and fair health again established. Sometimes, too, medication may be so applied as to directly lessen the virulency or vigor of the microbes, and their destructive work is then the m ' 1. y^ til! 62 CONSUMPTION : more easily checked as the natural powers of the body are gradually built up. In this way improve- ment may be brought about, slowly it may be, but surely. All diseased action may be eventually stopped, and the individual live on for many years: — with, it may be, a portion, or portions, of one lun^ bound down for life to the chest wall by pleural adhesion ; or a dried-up cavity in the lung ; or witli the scar of a healed one ; with, perhaps, an enwalled mass of dead, dried-up, calcarious, and so harmless, tubercular matter ; or some collapsed air chambers ; but w^ithal, no diseased action, no living bacilli or their spores to cause further destruction — except it might be through reinfection from without. |i! Ill lis iilil 11 ITS NATURE, CAUSES AND PREVENTION. 63 CHAPTEK IV. CAUSES OF TUBERCULAR PULMONARY CON- SUMPTION. IMPERFECT RESPIRATION AS A CAUSE. GENERAL REMARKS: HALF REMEDIES. Having sufficiently explained the nature of couHunip- tion, the causes of it may be now considered. Why does this fungus, the tubercle bacillus, grow and mul- tiply in the lungs and other tissues of certain living human bodies and give rise therein to tubercle, the special characteristic of this disease, and not in other bodies ? In short, what is the cause, or what are the causes, of consumption ? It seems evident, as we have seen in considering the nature of consumption, that the tubercle bacillus is one cause, indeed an essential cause, of the tubercular growths, and hence it must be regarded too as one of the causes of the disease. Practically, there is no con- sumption without tubercle and the tubercle bacillus. Unfortunately, since the discovery of this microbe by Koch, many authorities and writers appear to regard it as the cause — too often, practically, the only cause, instead of a cause, of consumption. The conse- quence is that frequently only half measures are employed for either the prevention of the disease or 64 CONSUMPTION : for trcatinj^ it with a view to cure ; hecuu.si' tlif incfiHurt'H are applied only, or almost only, to tlif destruction of tlie bacillus, and the other essential cause, or collection of causes, which favors its ^I'owth in the tissues, does not receive sufficient attention. It is clearly evident that there is another essential cause of consumption, one at least, ])esides, an<l (luitc as in«lispensable as, the bacillus; as this orj^anism will not ^ive rise to tubercle indiscriminately at any time in anybody's lungs into which it chances to be con- veyed. True, it is probable that no one is absolutely exempt from its effects ; that is, exem})t at all times and in any bodily conditions which may arise. Practi- cally, however, three-fourths of the human race flo escape altogether the poisonous effects of this \i})iqui- tous parasite, although doubtless repeatedly drawing it into their lungs in breathing. This is not by chance only. There must be some special cause for it. What then is it ? What are the conditions or causes which favor or permit, excite or enable, the bacillus tuber- culosis to grow, or set up the tubercular process, in tlic living bodily structures of so large a number of per- sons ? Again, what are the causes of consumption ? TWO ESSENTIAL AGENTS: AUTHORITIES ON. It is plain, then, that in the causation of this disease there are at least two distinct, immediate factors or agents, each apparently as important or essential as the other : ( 1 ) the virulent tubercle bp jilluh -i nfection, germ or seed, and (2) the a , recepf've, non- resisting or exciting body soil 'uunonly tci iiied pre- li ! ITS NATUKE, CAUSES AND PUEVENTION. 65 (lisj)oaition — that specially fitted condition of the l)ody tissue.s in which only the seed will develop and cause tuhcrcic ; and to the preparation or formation of which ji juiinlxT of mediate or more remote causes contribute. This is now the almost universal medical helitd": that tulu'rcular consiunption cannot develop without the tulx'rcle bacillus, nor can the bacillus oive rise to the cliiiracteristic tubercle except in specially conditi(med hodv tissues. Professor Von Ziemssen, one of the most eminent uuMJieal teachers and authors in Europe, says(Pulmon. Tul)erc.i translated by D. J. Doherty, A.M., M.D.: l)«'tr()it, Geo. S. Davis), " Experience compels us to iicknowledge that the healthy organism has jrreat power of resistance to the bacillus, which can make an cttbctive and permanent settlement in the lun<^s, intes- tines, etc., only when certain favorable conditions are })resent. These conditions, this as yet unknown patho- lon^ical something, we call a pvedlnpos'it'ion, and mean tlu'rel)y a certain constitution of the tissues which t'uniishes a suitable soil for the settlement of the bacilli. We cannot at present get along without the supposition of such a predisposition, which may be iitl»er inlierited or acquired. A disposition exists, in fact, for other infectious diseases, as typhus, cholera, dysentery, etc., and why should not one be supposed for the settlement of the tubercle bacilli ^ In what c'on.sists this predisposition which, next to heredity, plays the greatest role in the etiology of tuberculosis? We do not know." Doctor Thorne Thorne (Med. Off"., Local Gov. Bd., %■■'< 66 CONSUMPTION : Gt. Brit.: in St. Barthol. Hosp. Rep., Vol. xxvi) pyrites, " My object is to indicate that, though the bacillus is one requisite of tuberculosis, the soil — whether human or other — in which it can flourish is another necessary one ; and to urge that, whilst we are taken up with the fascinating research ^es of the bacteriologist, we may not forget how very usefully we, as practitioners of medicine, may occupj; ourselves in restraining the disease by securing the adoption of measures tending to deprive the bacillus of the pabu- lum it needs for its life-processes and for the pro- duction of the mischief involved therein." The late Sir Andrew Clark, Bart., M.D., etc. (Lect- ure on C)*.n. Cases of Tuberc. at Lond. Hasp.: Lancet, July, '92), after reference to Koch's discovery, said, " Now this brilliant discovery and the theory based thereon make it plain that there are two factors in the evolution of tuberculosis — the tubercle bacilli and the soil on which they grow ; for it is certain that these bacilli will not flourish on every soil." The late Professor Austin Flint, of New York, writes (Pepper's System of Med., Vol. iii), " If we accept the conclusion that the bacillus [of tubercle] is the causative agent, it requires certain local condi- tions. Without these, the parasite is innocuous. T!ie conditions are to its development aiid multiplication what the peculiarities of soil are to the production of different vegetables. We do not know the nature of these conditions. When they exist the bacillus de- velops and multiplies; when they are wanting, the parasite is incapable of development and multiplica- ITS NATURE, CAUSES AND PREVENTION. 67 tion. Thi? dependence of the specific morbific agent upon particular conditions is exemplified in other infectious diseases. The contagion of the eruptive fevers, received into the system ever Svi abundantly, is inoperative in some persons. The contagion has not lost its vitality; the conditions for its activity are wanting." Professoi Osier (Johns Hopkins Univ., Bait., Md.) records his view in the following apt words (Osier's System of Med.) : " There are tissue soils in which the bacilli are, in all probability, killed at once — the seed has fallen by the wayside. There are others in which a lodgement is gained and more or less damage done, but finally the day is with the conservative, protecting forces — the seed has fallen on stony ground. Third, thore are tissue soils in which the . bacilli grow luxuriantlj'" ; caseation and softening, not limitation and sclerosis, prevail, and the day is with the invaders — the seed has fallen upon good ground." Doctor Andrew H. Smith, of New York (at N.Y. Acad, of Med.), says, "There are two factors to be taken into consiHftrnfion^ one being the seed, the other the soil, and in proportion as we make these facts clear lo the public, will our advice for preventing the spread of tuberculosis be followed." When asked why so many escape when the tubercle bacillus is so plentiful, he answered by this illustration : " Rice sown on the top of a sandy )iill will never bring forth a crop ; or, prepare a river bottom ever so well, and sow no rice, there still will be no crop. It requires the proper seed, and also the proper soil to reap a harvest. : ;, ■1 mi iiiiiMiMMifc . - I. jMf^Hf i -Hi .U__iJ-ji^"i 68 CONSUMPTION : Hi; :! !l . I" llllll! Applying this to tuberculosis : to prevent dissemin- ation of the seed is very important, yet of equal importance is it to obviate preparing a suitable soil." Doctor Stephen Smith Burt (Prof. Clin. Med., New York Post-Grad. M'ed. School, at N.Y. Acad, of Med.) declares that, "As without this parasitic plant, how- ever depraved the constitution, there will be no tuber- culosis, also, fortunately, with this morbific agent there will be no phthisis unless the vitality of the tissues is first impaired. And Doctor E. H. Shurly, Detroit, says (Address, ann. meet. Am. Med. Assoc, '91), in respect to bacilli, " Their destiny depends upon a favorable nidus (nest) or pabulum." They " develop only where a previous abnormal ntate of the body suitable to them exists." It may be stated here, then, at once, that in our efforts to prevent consumption it is not enough that we use means only, or chiefly, for preventing the spread of the seed and its probable spores. The incalculable numbers of these germs cast off* by con- sumptives and existing everywhere render success in such one-handed efforts practically impossible. If, however, we at the same time make greater efforts to prevent the formation of the suitable stinmlating soil for developing the disease germs, we shall have at least double the chances of success from our preven- tive efforts: while, as w^e shall see more clearly further on, we shall also at the same time promote the develop- ment and growth of cleaner, healthier and more vigorous human beings. mMi ITS NATURE, CAUSES AND PREVENTION. 60 PKEDISPOSITION : WHAT IS IT ? One (.-.sential factor in the causation of consump- tion, the tnhcicle bacillus, having been sufficiently iliscuyseti, let us now incjuire carefully into the nature of that special condition of the human body, or body tissues and fluids, which constitutes the other essential factor — the soil, or predisposition — for exciting or fertilizing the bacillus, and of the causes which give rise to this condition. Let us, if we can, make plain why it is that many persons fall ready victims to the disease, while many more possess the immunity from it, — resist the destructive influences of the ubiquitous fungus. Let us, if we can, learn how all may retain or acquire immunity from consumption regardless or in spite of the bacillus. A great deal has been said and written, much of it long, long ago, on the subject of " susceptibility " or " predisposition " to, and on " predisposing " causes of, consumption. Almost all sorts of morbid bodily con- dition", and the causes of these, have been named and diseussvd as " predisposing " causes, or as giving rise to the predisposition : to which condition tiie term " favorable soil " or " suitable soil " has been more recently applied. Most of this has been unsatis- factory; much of it misleading. What the predis- position is, or the natu. of it, has never been fairly detined, hardly even in a measure. In his work recently quoted, Von Ziemssen describes the outward and visible signs of the inward hody condition. First, in reply to his own question — " In what consists this predisposition ? " Von Ziemssen says, " We do not 11 l^'';'!' ' i ! :.;,|i V ■, '*:■' 1 vm V.' ! :, 111 lii:: m I ! 70 CONSUMPTION know." He then continues : " We know in a general way how a man looks when he has such an inherited disposition," and the causes which may engender it ; " but we do not as yet know its nature or the mor- phological, chemical or physiological changes to which* it owes its origin." " Of the slender body, the flat chest, the thin limbs, the delicate tinge, the vulner- ability of the vessels of the mucous membrane, the tendency to nose-bleeding and to catarrhal inflammation of the larynx, the frequency of cardiac palpitations and congestions, the circum- scribed redness of the cheeks, etc.," there is often " but little to be made." He adds : " How many robust young people are tuberculous in spite of their compact l)odies, stout muscles and natural color ! Here there is still much to be investigated." Equally unsatisfactory are all explanations respecting the cause or causes of this predisposing condition of body which constitutes the tuberculous Hoil. Heredity has been long the great bugbear in con- nection with the causation of consumption ; but it is now well known that, as usually understood, it is not comparatively a very important factor, or is not so important as it was until recently supposed to be, as we shall see further on. Life insurance companies are less shy of it in applicants than they once were. Various sorts of depressing influences, such as insuf- flcent and improper food, exhausting discharges, over- work (mental or physical), night vigils in care of tho sick, unhealthy dwellings, alcoholism, atmospheric dampness and " colds," the eflfects of fevers and other II i'K':. I l''1 Bh lllllliiilil:!,!:. ITS NATURE, CAUSES AND PREVENTION. 71 diseases, especially those more particularly affecting the air passages and lungs, as measles and bronchitis, have all been put down as favoring more or less the formation of the so-called tuberculous soil. Breathing foul, prebreathed air in rooms, shops, schools, etc., from want of ventilation, has been long regarded by high authorities as a particularly strong predisposing cause of consumption. Probably this is more deserving of the charge, and to special con- sideration, than any other commonly named cause. In most cases of consumption, many causes and influences have been in operation. Anything which lowers the health standard gives rise to a certain amount or degree of predisposition to all infectious diseases, and indeed probably to all diseases whatso- ever, but not in a greater degree to consumption than any of the others. Again, persons who are naturally not of vigorous general make-up or constitution, or who are " weakly," or perhaps not in good general health, providing the lungs a-.e proportionately developed and exercised, are not particularly liable to consumption. Even anfemic — " bloodless " — persons have so rarely become sub- jects of the disease as to have been erroneously re- garded by some authorities as exempt from it. It seems impossible to ui^derstand how so many various kinds of causes can give rise to that special condition of the living body tissues which fits them for the growth and propagation therein of this fun- goid plant, the bacillus of tubercle, which, too, seems to demand for its growth a soil so peculiar as it J:' Ijl 72 'JONSUMFriOX ** Ijlllli!' evidently does ; and this the more so, because all per- sons upon whom these various causes operate, even in full force, or in whom the various conditions named exist, do not become tuberculous" or consumptive. A " scrofulous diathesis " or condition, or a " strunj- ous habit " or condition, are terms commonly applied to certain persons, mostly young (they often do not survive adolescence), who are found to be more par- ticularly disposed to various forms of tuberculosis. Such persons are marked by the characteristics quoted from Von Ziemssen, and are subject to gland- ular enlargements in the neck, to tubercular diseases of joints and bony structures — " white swellings " — an 1 prcbably, in well-mark ;d cases, have a thickened upper-lip, and a partly-ope^. mouth, habitually, from swollen, obstructed nostrils. But whence or what is the cause of this condition — the " scrofulous habit ? " It is often hereditary ; yet often acquired, especially in cities. High authorities have declared that it may be caused by breathing a foul, especially a pre- breathed atmosphere. This brings us now nearer to what in my opinion will be found to be most intimately and directly associated with the special cause of the production of the tuberculous soil or predisposition — intimately and directly associated with the second essential factor in causing consumption: namely, a proportionately small breathing capacity — small or defective lung membrane surface — insufficient respiratory action or function. Consequent on this there is, first of all, a want of sufficient oxygen in the body for that perfect to heal coniplet puritica in the i matter For the intoxiea future respirat( Some others n pose to I breathin of the 1 Hence tl And an^ time res< function- ing foul been saic causes of (W. S. ( Brit. Mec tions ten rickets, p on the ( morbid c( Now, ii factor nii we may i! ''ililSii ITS NAtURE, CAUSES AND PREVENTION. 73 perfect tissue change or metabolism which is essential to health and life; practically, insufficient for the complete oxidation of the waste products of life and puritication of the blood : and, second, accumulations in the air chambers, fluids and tissues, of such dead matter as on decomposition affords inorganic food for the saprophytic bacteria, as well as, probably, intoxicating organic substances to be noticed on future pages, — dead matters which, with a perfect respiratory function, would be thrown off. Some of the above-named predisposing causes, and others now long recognized as such, first of all predis- ])08e to a want of full respiratory action — to shallow breathing, or a morbid, perhaps thickened, condition of the lung membrane forming the air chambers. Hence these are indirect or remote predisposing causes. And anything which habitually or for a length of time restricts the breathing or obstructs the breathing function — the free exchange of gases— such as breath- ing foul air, is a remote predisposing cause. It has been said, for example, that "most potent predisposing causes of tubercle in infants are rickets and measles " (W. S. Coleman, M.D., M.R.C.P., etc., at ann. meet. Brit. Med. Assoc, '93). Why ? Because these affec- tions tend strongly to limit the respiratory function : rickets, probably chiefly by its contracting influence on the chest and lungs ; measles, by producing a morbid condition of the air chamber walls. Now, is it not possible that this .second causative factor may be more clearly defined, in order that we may bring our preventive forces mo directly mf 74 roNSUMPTlON ,*^:h '■ ,if ' against it ? We have learned clearly enough that it is an absolutely essential causative agent. It seems highly probable, taking in all the circumstances, that it is something more definite, special, peculiar, than it has been generally supposed to be, — something actual, more than a negation, more than a want, as of vigor or " tone," more than defective nutrition or lowered vitality, — that it is a positive substance, antecedent to these conditions. Is it not probable that it is a poisonous substance, perhaps of the character of a ptomaine, produced in the body from the decomposi- tion of the retained debris of imperfect tissue change or wear and combustion, consequent on imperfect res- piration ? and that this, while depressing the vitality of the entire body, including the protective phagocyte cells, also, and particularly, acts as a germ excitant or intoxicant, probably along with a germ nutrient from the same source, and so gives rise to the virulent action of the bacillus and the eventual production of tubercle ? The lowered general physical vitality which is now looked upon as the effect of the tubercular state, is probably a pre-tubercular condition, the result of the action of this substance and not of the bacillus. It is my purpose to show now that some such sub- stance is probably produced in the body, and is more truly the immediate exciting cause of consumption than is the tubercle bacillus. We may not be able at the present time to make it clear — to put our finger upon it, as in the case of the seed — but we may learu enough to enable us to work more successfully toward removing this second, personal or body factor, or preventing its formation, than we are now working. liii.i- m,:^ ITS NATURE, CAUSES AND PREVENTION. 75 : VEGETATION AND SOILS. Before I proceed further to endeavor to bring out evitknce in support of the theory that a toxine formed in the body excites th'» tubercle bacillus into pathogenic action, it will be well to touch very briefly upon tlie nature of vegetation in general in its rela- tion to soils ; and more particularly upon the relation to so-called tissue or body soils, — as well as to various conditions of circumstance and environment, of these lowest known forms of plant life to which the tubercle bacillus and other disease germs belong. We know that while some of the more highly organized plants will grow and flourish in some localities and soils, thev will not in others, as well illustrated in the quotation given a few pages back from Doctor Andrew Smith, respecting the growth of rice. Some seeds will not grow in low damp ground : others will not in high and dry places. In some soils there is a want of some certain element which certtiin plants need, while in others there are elements antag- onistic to the good gtowth of certain plants. Tem- perature, of course, has much to do with plant life, the plants of the tropics not flourishing in northern climates. Somewhat so it is, doubtless, with the human body and the parasitic, disease-producing vegetal organisms called germs or infections. Some children long escape scarlet fever although often exposed to its infection, and probably taking it into their body ; yet they may take it later in life when in another different, or a special , body condition, or it may be when exposed to a more virulent infection. 76 CONSUMPTION : • 1 fi; ■ ]■ ;;i>,,ir- :!l|liii Some individuals will not take small-pox even when much exposed to the disease ; their body does not provide the special condition in which only the infection can develop. The vaccine virus will not " take " in some pei*sons. As Doctor Flint words it, " the contagion has not lost its vitality ; the con- ditions for its activity are wanting." Comparatively few of the population — one-eighth to one-fourth— take consumption. Why ? RETAINED BODY EXCRETA: CARPENTER'S THEORY. It is well known that when the excretory organs of the body — the skin, kidneys, lungs — are not in a healthy, active condition, it may be, from overwork of the organs, then the waste products of life — of tlie wear and tear of the tissues, of ' the combustion by which the body is kept warm, and of products of excess of food consumed — are not thrown out by these organs, as in health, but instead, accumulate in the oiood and other fluids and tissues of the body, con- stituting impurities — dead, decomposing matter, " food for bacteria." Doctor Burt says, " Waste products circulating through the organism, not properly oxy- genated, form an attractive field " for bacteria. " The food of the tubercle bacillus is the debased blood and tissue which have been inherited or acquired." Eighteen years ago, in an address at the annual meeting of the British Medical Association, Doctor Alfred Carpenter announced it as his belief that the retention of used-up waste matter in the blood, from want of proper activity of the various excretory irl'^'fliii! !!.iiii':!;i:'^ ITS NATURE, CAUSES AND PREVENTION. 77 ororans of the body, is one of the essential causes in tlie development of infectious diseases. Doctor Cai'|H'iiter then advanced a theory which is in sucli exjict accord with my own experience and observation since that time that I quote his words, at considerable l(*n^4li, as follows (Can. Health Jour., Vol. ll, Sept., 76) : " I niich doubt if these living organisms [disease trerins] could have any effect upon the body if the recipient of them were perfectly healthy ; if no impurity existed in the fluids of the body ; if the lilood contained nothing foreign to a healthy and natural state. If this be so, a question arises as from whence these impurities proceed, and how tlieir effects are to be guarded against. I venture to put forth an hypothesis for consideration, wliich will explain much that is difficult to understand on any other view. Some impurities must exist; they ai'e the used-up matters, the result of the act of life, or they may be inherited tendencies, which have lesulted from former neglect of sanitary law, and which have depreciated the quality of the stock and rendered it more susceptible to bad influences. The impurities naturally increase if there are any defects in the sanitary arrangement of the individual cor/tun. Tlieir presence is of no moment if they are not in excess, and if they are removed from the body as fast as they are formed, or in the course which they naturally follow. Let me represent them by x in an equation in which the factors x, y, z (as a total) represent any form of infectious disease. The pro- blem is to assess the value of each factoi i the equa- IWW 78 CONSUMPTION : tion. . . . Let x equal u and e : u being the used-up material, always in the act of formation, is not iort'i^ matter, and is not in ordinary proportions injurious to life. It is always being diminished as fast as it is formed by one or the other of the excretory or^^aus which exist for the purpose of renioving it. If all the excretory organs and all the functions are healthy, and all doing their work properly, the body is in gool health, there is no excess of used-up material, no debris of combustion. If, however, one or other of the ex- cretory organs fails to do its duty from either over- work or inertness, somethins is left in the humoral sj'^stem, and e [the second subf actor forming x] is added. It becomes a positive quantity, and represents the excess of matter which should have been removed; u and e equalling x. They have a common origin, being the debris of the act of living ; e will differ in quantity as well as quality. It will be modified by personal character, by actions, by non-actions, and even by attainments, but especially by attention to, or neglect of, sanitary and moral laws . . . If e be absent, x is not complete, and x, y, z [the infectious disease, or epidemic], cannot arise. . . . The germ or living organism, z, the particular contagium, the multiplying focus of infection, has to be introduced from without, and is capable of modification accord- ing to the character of the soil into which it may happen to be transplanted. . . . Just as pencillum glaucutiL requires the sugar and the temperature to produce alcohol, So z, the contagium particle [in order to cause disease], requires the food upon which II. 1 :: ■: fi!ln Jiiiiiti;:'! ITS NATURE, CAUSES AND PREVENTION. 79 it increases and multiplies. . . . The severity of the (iisease will depend, not upon the character of z, hut upon the quantity of e, which exists in the factor X : z will be reproduced according to the ([uantity of food, in the recipient body, upon which it can increase and multiply. If e be absent, the effect of z will be nothing ; there is nothing for it to feed upon. If, therefore, personal cleanliness be attended to, if all the excretory organs of the body are properly exer- cis'.'d, . . . the effect of z, whenever it happens to be introduced into the body, will be reduced to a niini- muni.and may be so dwarfed as to be unable to effect a lodgement ; it may die out entirely. It will be by directing attention to the necessity of diminisliing the growth of e that we shall prevent infectious diseases from spreading, rather than by useless attem|)ts to keep out z." Certain meteorological states, Doctor Carpenter represents by the factor y, as above given. These may, it appears, in a measure influence the body condition, or the infection z, making it less, or more, virulent, as by atmospheric dryness or moisture, etc. Doctor Carpenter says, " A municipal authority, who allows overcrowding, foul air, immoral acts on the part of the people, impure water or bad food, is providing an excess of e, and increasing the danger which may arise from the introduction of z." ' <i 1:f WHO TAKE INFECTIOUS DISEASES? Now, who are the people who, as we find in practice, most commonly " take " infectious diseases ? Not the clean-skinned and clean-blooded. V, 80 CONSUMPTION : I, It may be most reasonably and fairly conclurlcd that the Creator never intended man — that iium never was desijijned — that it is entirely contrary to nature for him — to become the easy prey of any of these low forms of parasitic life so long as he lives in a proper ^nanner — in reasonable accordance with tlic requirements of nature or of health ; barring, per- haps, cases in which ancestors had greatly " sinned." Charles Denison, A.M., M.D. (Prof. Chest. Dis. ami Climatol, Univ. of Denver, Col. : Essay, " Exercise for Pulmonary Invalids ") says, " It must be, indeed, a peculiar accident which will result in nature's luir- boring tuberculosis in a physically perfect huiimii being. But accidents will come, and perfection to meet them is very seldom or never to l)e found. Vov this reason are we doctors." It is well known that besides the great majority of mankind who are hardly in any way clean, theif are many persons, many most estimable persons, wlio. while absolutely clean of skin — clean on tiie outer surface — from frecjuent and regular bathing are not clean within : whose blood and other body flui<ls, ami even tissues, contain an excess, small or greater, of used-up, waste, dead matters, the refuse of the func tions of life — the dust f wear and the ash of com))Us- tion : — which in well-proportioned, well-functioned, and well-cared- for bodies are cast out gradually as thev are produced by the excretory organs. Briefly, in a very large proportion of the people who make up tlic masses of humankind, on account of some (.n'ganic defect or bad habit, either inherited or accjuired, such """■IP ITS NATURE, CAUSES AND PREVENTION. 81 as that of a small chest or habitual shallow breathing, these waste matters are not in their full measure cast out, but accumulate in the body, constituting the e of Carpenter — "attractive food for bacteria." OF THE POISONS (iENERATEI) IN THE BODY. There is a great deal yet to be learned concerning tlie chemical and physiological changes which take place in the blood and other fluids of the human body from an excess therein of the waste of the pro- cesses of life — concerning the leucomaines, ptomaines and the many other combinations formed thereby ; and concerning the relations these bear to saprophytic ami other micro-organisms in the body, and also to certai'i bodily derangements. It may yet be found that such combinations constitute special attractive sustenance for special micro-organisms, which are, or which may only then become, the germs of disease, — combinations perhaps poisonous to the body, which tlie so-called disease germs are benignly designerl to appropriate — to consume, break up or destroy, for the preservation of the body. Toxic substances are pro- li.-'bly thus formed which transform benign micro- orjxanisms into pathogenic or disease-producing germs. Only a few years ago the late Sir Andrew Clark made it clear that anfemia and chlorosis (" green sick- ness ") are caused by poisons arising from retained ficcmnnlations of fecal matter in th«' intestines — by IVcal poisoning or intoxication — a conrlition which Bouchard designated as stercorfemia : as li. cases of habitual constipation in young women. There is I) ; 82 CONSUMPTION : ;ljijH| evidence, an<l appears to l)e no doubt, that to^iii* s from the same .sourcf freoi ntlv^ iriv^e rise to so-call(Ml " malarial " atteetions, iier. '\lj;ias, " biliousness," and various forms of headache. Fron» observations and experiments by Doctor Hattie, of Halifax, Nov., it appears that ('pil«-ptic seizures sometimes have a like orifi^in. Docl-'r Hattie's conclusions are sup- ported by Doctor \'. Romaro (La Sema. Med.: New- York Med. Jour., Nov. 24, '94) : who, furtliermorc, has found inhalations of oxygen " very beneficial " in the treatment of such " convulsive neuroses. "The oxyg(-' " he says, "counteracts the asphyxial state of tlie tissues and destroys tlie ptomaint's, t*"e accumulation of which in the orji^anism is often responsible for the convulsive paroxysm, " It is not yet known whetlier these poisonous ptomaines act on the body directly, or whether they act throu;.'-'' the influence or medium of certain micro-orj^anisi It is not improbable that the poisons first ati'eet certain microbes. It is unlikely that tlie typhoid fever bacillus will «^ive rise to its poisonous effects except in a foul intes- tine; nor will the cholera vibrio. Nor is it at all likely that the tubercle bacillus will give rise to tubercle in a clean, fully used and well-ventilated lung. The foul, stagnant air — air loaded with accumulated eft'etc matter — in the remote recesses of the air chambers of the lungs, from want of full respiratory action, consti- tutes a favorable condition for its saprophytic life, ami where, too, it may be readily influenced and changed- - made virulent, or more virulent, by abnormal toxincs ITS NATURE, CAUSES AND PREVENTION. 83 ARE DISEASE GERMS ORIGINALLY BENIGN J a The ^ernis of typhoid fever and consuinption are uhi(iuitou8. Yet vvith a large iiiajority of persons, into whose body they an^ doubtless often received, they are practically harmless. May we not ask, are they not sometimes, as in their natural, saprophytic condition, actually even benign organisms — scavengers, working in accordance with natural, universal law ? ht'coniing virulent and pathogenic in consequence of iiian's own unhygienic habits — intoxicated into viru- letice by poisons generated in the human organism :* One well-known bacillus, which is, it appears, con- stantly present in the healthy human intestine, the bacillus coli communis (common bacillus of the colon — lower bowel), is in its natural state evidently a benign ortjanism. Yet the results of investigations make it hitrhly probable, and to the minds of some of the liiji^liest authorities, absolutely certain, that it is some- times in some way, especially in collections of excre- ment, as in privy pits, and possibly in a foul intestine, transformed into the virulent bacillus of typhoid fever : thus satisfactorily explairing the occasional so- called dc novo origin (arising ane.v, not directly from another person) of this disease. For that it does some- times arise in some such way, de novo, has been long maintained by high authorities ; as apparently also <lo other infectious diseases, as diphtheria and tyj)hus. True, Doctor Klein, F.R.S., etc. (address at Sani- tary Inst., Sept., '94) tends to throw doubt on this. Vi't the slight though persistent differences Doctor %!*; ii'-t (; * 84 CONSUMPTION : 1 « Klein finds between what he believes to be two dis- tinct organisms (the bac. coli and bac. typhosus) may on further investigation be reconciled to the view that the}'' are originally one and the same. The poly- morphism (change of form) of these low vegetations is as well known as it is remarkable. We may note tlie different forms taken by one of the minutest of them, the micrococcus: — thread-like, spiral, and dumb-bell forms. From the investigations of Metschnikoff, Weiber, Wiltschur and others, it appears evidcnit that the cholera vibrio, the coma bacillus, of Koch, takes other forms, and under the influence of various external conditions changes both its morphological and biological characters so that " it may even become indistinguishable." And it is asserted that these changes do not warrant the belief that there is more than the one variety of cholera germ. Dickson, of Philadelphia, and other investigators have obtained thread-like, branched and club-shaped forms of the tubercle bacillus. In the ostrich, Crookshank informs us, this bacillus is very lon^^ and sometimes presents a " terminal enlargement " (Com. to Path. Soc). Klein himself not long ago, it appears, stated that the bacilli of diphtheria, of anthrax, and even of tubercle, are variable and not such well-marked typical bacilli as they have been supposed to be. Furthermore, since writing the above, I find in the British Medical Journal (March 9, '95), after some comments on " a detailed account of the morphology " (form and structure) of the tubercle bacillus by Coppen Jones, the following, by ^iH ITS NATURE, CATSES AND PUEVENTIOX. 85 tlu; L'ditor of that journal : " The polymorphism of some of the higher funj^i is referred to ami a number of observations are mentioned, which ten<l to show that bacteria formerly looked upon as monomorphic [of one form] are only stjij^es in the development of more complex forms." Bunge, contrary to Klein's experience, has found the larger nmnber of Hagella or cilia (seemingly the motor organs), on the colon hacillus. Doctor Veranus A. Moore (Bureau of Anim. Indust., Wjish., D.C.) says, the flagella of such closely related bacilli as these two and that of hog cholera " resemble each other so closely that they cannot be considered as specific characters." It is, then, easy to believe that the typhoid bacillus, notwithstanding its (lirterent eftects on milk, etc., as observed by Klein, may be a transformed cohm bacillus. Cilia may but l)e pushed out to enable the organisms to reach the surface of their containing liui<l in order to obtain oxygen; possibly a temporary change. However this may be, it is evident that the common benign bacillus coli is not infrequently transformed, if not into the true bacillus typhosus, into an equally virulent <lisease-producing germ. The editor of Modern Medicine and Bacteriological Review (Aug., '94), after referring to investiga- tions by Doctor McWeeney (Prof. Path, and Bac. Royal Univ. of Ireland), in a case of fever indistin- j,'uishable from typhoid, but which disclosed no other infection than the bacillus coli, and also in an epidemic of typhoid fever at Watcrford, England, remarks : " Tlie evidence afforded by these observations is, that a K/ 86 CONSUMPTION bacillus possessing the characters of both Eberth's bacillus [of typhoid] and the bacillus coli is capable of producing typhoid fever, and that a disease indistin- guishable from typhoid fever may be produced by a microbe which is unquestionably the bacillus coli." Doctor Gabriel Valet, indeed, has shown that by cul- tivation of the bacillus coli in fecal solutions, it may become more virulent, more poisonous, than the typhoid bacillus. Now, what so changes the character of this usually benign, probably very useful micro-organism, inc. bacillus coli ? Doubtless some toxic substance formed in the decomposition of the fecal matter. Is it not probable that such substance may be formed in the decomposition of accumulations of fecal matter in tin; neglected intestine of a living human body, and there and then produce a like effect upon this bacillus ? It need hardly be stated that this part of the sub- ject has Ijeen thus dwelt upon with the view of show- ing that it is possible the tubercle bacillus may Ix' influenced and transformed in like manner from a benign saprophyte into a parasite or pathogene by the foul air iTi the air chamber's of the lungs, or by poisons generated therefrom. It may be here observed that in accepting the theory of p<ilymorpliism as correct, to the utmost limit, it is not denied that like produces like, persistently, in like influences of circumstance and environment. ITS NATURE, CAUSES AND PREVENTION. 87 EFFECTS OF ENVIRONMENT ON DISEASE GERMS. With the view of showing further liow certain body conditions may affect the tubercle bacillus when it chances to get into the body of certain persons, and of drawing more special attention to the l)ody causa- tive factor, the " personal equation," let us briefly notice the dij'ect efi'ects, upon some of these low forms of life, of the conditions in which they are placed or which surround them, — of oxygen and sunlight, of cultiv'ation, of soil and temperature, and of the diet and habits of the host in which the organisms live. That associated circumstances and conditions — air, soil, food, etc. — have marked infiuences and effects on the life and characteristics of all living organisms, animal and vegetable, is well known, and need not be t'ui'ther noticed. Man himself is largely a '* creatin*e of environment." Crookshank says the importance of environment on micro-organisms is shown by the morphological ilitferences obsoi-ved in artificial cultivation under varying conditions: and, he adds, by the fact that by successive cultivation the tube-^e bacillus can be " educated to grow upon n medimu which is unsuit- able for obtaining primary cultures." And it is well known that by various foi-ms of cultivation, espe- cially through the bodies of certain lower animals, tiie virulency of many disease germs lias been so reduced as to give rise to the practice of inoculation of the thus attenuated germs or their milder products as a preventive measure. Trouessart states that the siime m mm 88 CONST 'MI»TI(»J % ' ijf l;!i;: jI?5SI!1!l|i«. i '} result may be obtained by adding various antiseptic substances to culture liquids, and thus weakening tlie virulency of the microbes. Doctor Arthur Ransonie, F.R,S., has reported a series of observations (Proceed. R. Soc.) to prove that fresh air, light, and a "sandy soil have a distinct influence in diminishing the viru- lence of the tubercle bacillus." The soil he appeared to regard as having a special influence. It has been long ago observed that consumption is more prevalent in communities living on impervious, moist soils than amongst those on open, dry soils : a subject whicli will be more fully treated in another connection. Trouessart says, " Certain facts observed in medical practice ha\t' led to the surmise that whooping-cough may l»e regarded as an attenuated form of croup, just as vaccinia is an attenuated form of small -pox." On tlu- other hand, fowls are not naturally susceptible to splenic fever, or anthrax (a disease communicable to man), but Pasteur rendered them susceptible by immersing them in water for two or three days and so reducing their temperature, which is higher than that of mammals. Chauveau has shown that com- pressed oxygen will considerably modify the virulence of the bacillus of anthrax ; confirming Pasteur's view that the oxygen of the air attenuates, and even extinguishes, the virulence of an infection. The rat, susceptible to the anthrax infection when subsisting on a vegetable diet, is not so when on an animal diet. The house-mouse may be inoculated with septicsemic (" blood-poisoning ") infection from another house- mouse, but not from a field-mouse, and vice versa. It "■iPVi ITS NATURE, CAUSES AND PKEVENTION. 89 lias lieen the subject of observation that epidemic and otlier diseases, Asiatic cholera, for example, are mure viriih lit a few days after the Sunday feasting in whicli the masses (jf the population connnonly indulge. There appears to be now no doubt that the virus of vaccine matter, the specific infection of the mild cow- pox used in ordinary vaccinating, is originally the same as that which gives rise to small-pox in man. By culture — by passing through the body of the bovine animal, the viruhuicy of the infection is modi- fied. Appar^'iitly originally from bovines, it becomes in some way much more virulent in the lx)dy of man. On the othei" hand, how is it, it may be asked, in the case of direct inoculation with lunnan small-pox infection, from man to man, for producing j nilder ionn of the disease i — a preventive measure intro- (luced into western Europe from the East and much practised a century and a half ago. The individual to ))e inoculated is subjected to a course of prepara- tory hygienic treatment, in order apparently to ck'anse the body from excess of effete matters or impurities and invigorate the system. Is it not pos- sible that, if this preparatory treatment were pro- perly carried out for a sufficient length of time, the l)0(ly would b(^ then so purified and invigorated tliroughout that a natural imnnmity would be thereby brought about as efiectual as by the inocula- tion process ? — that then the infection when inocu- lated into the body would not give rise to the disease at all or produce any noticeable effect ? Is natural immunity and the usual exemption from a second ■ ] 90 CONSUMPTION attack of an infectious diHeasc anything more than the influence of a complete cleansing and purification of the body, together with a certain adaptation of tissues and functions to any future action of the same infection ? ii: 1^ DORMANT OR LATENT GERMS IN THE BODY. A few. words here on this subject will be instruc- tive. In the case of all infectious diseases a perio<l of time elapses l)etween the time of taking the infection into the body and the manifestation of the symp- toms, or the apparent commencement of the disease. This is termed the period of incubation, and varies in the different diseases ; and also, mark, in the different individuals. That there should be such a period is easily understood : it being the time required for the special infective germ to propagate itself — multiply— and spread its influence. But why does this period vary so much as it does sometimes in different indi- viduals in the same disease ? This must be caused chiefly, if not entirely, by a difference in the condi- tion of the body fluids and tissues — the body factor ; the variation in the virulence and fatality of differ- ent epidemics of the same disease being doubtless due. in the main, to variations in the virulency or vigor— the more luxuriant growth — from the start, of the infecting germ : atmospheric influences, too, some- times having an efl'ect. Aside and quite different and distinct from this incubation period, disease germs sometimes lie in the human organism, apparently in a latent or dormant ITS NATURE, CAUSES AND PKEVEXTIOX. 91 state, doing no harm, for weeks or months and possibly a longer time. This is not easily accounted for. It can only be reasonably associated with the body condition, or explained by variations in that con- dition. Doctor R. 8. Adams (Med. Rec), in a series of recent throat examinations, found the bacillus of diph- theria — the Klebs-Leoffler bacillus — in the healthy throat, " doing apparently no harm." Trouessart, believing that the dual nature of the diphtheritic infection is not yet fully established by the researches of Klebs and Leoffler, but that the apparently two organisms are but different phases or forms of one, explains the origin of a case of the disease in this way : A child contracts a simple catarrhal angina or laryngitis (an inflamed condition of the larynx); the micrococci, which up to this time reinained inert in the mouth, begin to grow and nuiltipl}^ under the influence of the inflammatory products which favor tlieir development; the plant which has been dor- mant becomes widely diffused. There are many <legrees, he adds, between croup with malignant complications and the mildest diphtheritic angina. From recent investigations by Straus (N. Y. Med. Jour.), it seems that living tubercle maj'- exist in the nostrils of healthy persons and not give rise to any ill effects, although they act virulently when afterward inoculated into certain guinea-pigs. Dur- ing an epidemic of measles in Munich, Bollinger had repeated opportunity " to demonstrate on the bodies of children who had died of that disease, the presence of tubercle bacilli in the lymphatic glands, especially H. U IMAGE EVALUATION TEST TARGET (MT-3) # // (■/ s / y. ^ 1.0 I.I "- ilia 5" 1113^ 2.2 1.8 1.25 1.4 1.6 .« 6" ^ V] ^:^ % / /^ ^^^W'^ ';' Hiotographic Sciences Corporation 23 WEST MAIN STREET WEBSTER, N.Y. 14580 (716) 872-4503 <9 '&0 ///// ^ 92 CONSUMPTION % ^1 hi' ''ji'; ■ 1 i, ;, : 1 i;: "'. i''. ■ iliiiiii mm of the root of the lung, although previous to the sick- ness the children had been apparently healthy and not at all scrofulous." Baumgarten believes children may be born with the tubercle bacillus or its spores in their body, and that the future history of the germs "depends on favorable or unfavorable conditions of the tissue soil of the host." Solles, taking a similar view respecting children inheriting the actual seeds, says that during the first years of life "there seems to exist a period of variable duration in which the spores of whe bacillus, although capable of being stiri id into activity, are yet capable of being thrown off," as by the excretory organs. (He did not use italics.) Ziems- sen says, " Cases of unintentional ' tubercular inocu- lation ' have occurred, where a slight injury (such as drawing a tooth, a small cut, etc.) has led to secondary swelling of the neighboring lymphatic glands, and in these glands, after extirpation, giant cells with tuber- cle bacilli have been i'ound. Such cases, however, are of doubtful value, for the bacilli may have dated from some earlier period and may have merely be- come manifest by reason of the traumatic lymphaden- itis [inflammation of the gland caused by the wound]. The value of experimental inoculation must remain doubtful so long as we have no guarantee that the lymphatic system was previously free from bacilli, and for such a guarantee we can scarcely hope. . . . That tuberculosis may exist and, perhaps, has existed for years in a child apparently in full health is often learned accidentally. A single swollen gland, carefully extirpated from an otherwise blooming and healthy ITS NATURE, CAUSES AND PREVENIION, 93 child, has been found to contain giant cells with bacilli. How long were these in the body ? Are there other foci of infection in the glands ? Who can answer ? " There is much truth in the remark of Doctor Mays, that tubercle, in itself, consequently the bacillus of tubercle, is not so deadly as it seems to be when judged from a standpoint of acute pulmonary tuberculosis. " It would not possess such a great fatality were it not that it involves and overpowers organs the full integrity of which is absolutely essential to life." It is well known, too, that cows may be apparently in the best of health and condi- tion, and continue to give abundance of milk, while in various tissues of the body are numerous tubercles. Brush says the bovine race can be tuberculous from birth to old age, and yet not die of this disease. On the theory that saprophytic or benign micro- organisms may be transformed into pathogenic germs — that so-called disease germs in the body doing apparently no harm may be rendered virulently active by certain bodily conditions, the various anomalous cases, or series of cases, of illness occasion- ally reported, as well as the de novo origin of typhoid and other fevers, and of consumption, and also certain other peculiarities in connection with germs, may be fully and satisfactorily explained. M EFFECTS OF IMPERFECT BREATHING. Without further discussion or inquiry as to whether or not it be probable or possible that the tubercle bacillus has ever been, or may still be in 94 CONSUMPTION /■'I i 1 ■ t 1 certain circumstances of environment, of a Ijenign or purely saprophytic character, we will now after these lengthy and somewhat digressional remarks on micro- (•rganisms, return to the further consideration of the so-called predisposition, or soil factor. Forty years ago, in my early student days, from a special case which deeply interested me, I received a strong impression that defective respiration — a want of full respiratory capacity or activity — constitutes a particularly important factor in the causation of con- sumption. The more thought, observation and study since then given by me to the subject, the more con- vinced I have become that such is the case. Indeed, previous to the remarkable developments and dis- coveries in biological medicine during the last decade or two, the belief was growing thai; the disease could be produced solely by want of full expansion and exercise of the lungs : and it is now my firm belief, that no one will ever have it so long as pure, cool air, with abundance of oxygen, passes freely into and out of, and fully inflates, every air chamber and keeps them free from the accumulation of the waste matters dumped into them from the blood. During a third of a century in practice, I have had many opportunities of observing and studying, on the one hand, the evil effects of want of full respiratory capacity, whether inherited or acquired — tuberculosis being the most common ultimate result ; and on the other hand, the good effects, often prompt 'and marked in consumptive persons, following an improvement or increase in the respiratory function, I could, would space permit. !:::. ^ ITS NATURE, CAUSES AND PREVENTION. 95 give the detailed history of many cases clearly con- firmatory of this. When we bear in mind, what may be here repeated, that all the blood in one's body, after it has been the lound of the greater circulation — to every part of the l)()dy — given up to the tissues its charge of oxygen, and gathered from the tissues its load of used-up waste, is sent from the heart to the lungs ; that there, spread out in the capillaries laid over the air chamber walls, about once every minute, it all moves slowly enougli to give off' its load of waste stuffs and get in exchange its red corpuscles reloaded with life- giving oxygen, before it flows back to the heart to be again sent ' ^o all parts of the body ; and also tliat in natural respiration the air chambers aie first fully expanded, and then they contract and force out the waste matters with the breath into the outer atmosphere : — when we remember this, then it is easy to understand the evil effects on the system of shallow breathing with small or cramped, contracted lungs — of want of full expansion, with free ventila- tion, of the air chambei-s. When the air in the air chambers is not renewed in a proper measure as it should be w^ith every breath, but instead, becomes stagnant from want of being changed by full breath- ing, it soon becomes loaded with poisonous materials from the blood, gathered from all parts of the body. The blood can then no longer continue to fully unload itself into the chambers already overcharged with waste, and so the poisonous substances accumulate in the blood. Furthermore, the blood corpuscles cannot «)', \ 96 CONSUMPTION 'i ! now get their load of oxygen, for it is not to be had in sufficient quantity from the foul air in the air chaniberH. The entire organism then suffers in the various ways already explained. It will be well to note here the remarkable fact that the human body will gradually adapt itself, in a measure, to various insanitary conditions. For example, one may in a little time, from use, breathe an atmosphere, as in a crowded room, which at first seemed quite unbearable. But as Kirk says (Phy.s., Vol. i), " Such an adaptation can only take place at the expense of a depression of all the vital functions." In the case of acquired defective respiration, tlie system often tolerates the injurious effects for a lon^r time without manifesting any particular symptoms of injury, — the effects coming on, too, gradually, as the habit of shallow 1 ireathing gradually increases ; such respiration is injurious from the first, all the same. In persons in whom the lungs are relatively small from heredity, although fairly exercised to their full capacity, the ultimate effects on the organism are much the same as in persons with imperfect action of relatively larger lungs. In the smaller lungs, although the blood probably circulates more rapidly through them and the breathing is quicker to com- pensate for the want of space, yet it seems impossible, other conditions and circumstances being the same, that the blood can as completely unload its excess of refuse and receive its full cargo of oxygen as it can in relatively larger lungs. The smaller lungs, too, are more likely to be overtaxed, and are more liable to ITS NATURE, CAUhES AND PREVENTION. 97 congestions. Many of this class of p-.rsons exercise their lunj^s to the full capacity, and with hygienic care live on to a Ivanced age, in fair, though not in vigorous health ; yet as will be presently more clearly sliown, they are more liable to consumption than persons in whom these organs are better developed. Many of the class, on the other hand, do not, from habit or other cause, fully expand and use the small lungs they possess ; and hence a condition eventually even worse than in those with imperfectly exercised larger lungs. Children born with relatively small lungs are found to have usually, along with other characteristics, a more or less puny constitution, with a tendency to " shortness of breath " and palpitation of the heart, and to be " thin in flesh." With favorable surround- ings and habits, they survive the period of infancy and childhood, and in fair health. They may live so through the period of school life with its inspiring, lung-expanding plays and games; sometimes mani- festing great mental ability, as if to make up fcr want of physical power. So long as the respiratory capacity is not overtaxed by tissue change — by labor or exercise, if the skin be kept active and, above all, only pure air be breathed, such pereons may enjoy j]food health to the full average of life. During the closing years of adolescency, however, at that matur- ing and somewhat delicate period of life when con- sumption gathers in its largest harvest, it may be from a want of the inspiring exercises out of doors, or from " over study," so-called, indoors, or from tog ■t ,1 ■•i V ifi. 98 .'ONSI'MITION much physical labor in un ventilated working places, respiration, naturally not vigorous, beconjes more and more inactive and imperfect, the lunj^s and the blood become foul, tubercle bacilli are inhaled, and eventually tubercles are formed in the lungs. If now, because of the symptoms to which the tuberck' gives rise ami the consequent awakening, anxiety or alarm, pi'opcr I'emedies be employed, the tubercular process may l)t' arrested aiul fair health restoi'ed : if not, aiiothcr death from consumption is eventually the consequence. SPECIAL COLLblCriVE INVESTIGATIONS. Over twelve years ago, through the coui'teoiis aid of a number of the leading medical journals, I sent out to practising physicians in the United States and Canada a series of questions, with blanks for replies, respect- ing the causes of consumption. Replies were received from physicians throughout many of the Northeiii States and the Dominion of Canada, and much valu- able information was obtained relating to the personal history of a large number of consumptives. 'I'he replies showed that in all the cases reported upon, the chest dimensions were less than the average of well-developed individuals of the same height and weight, as given by the best authorities (as in table, page 36) ; the average of the cases being in fact only about live-sixths of the dimensions demanded by healthful development. The measurements had been doubtless taken after the disease had made con- siderable progress ; but the reduction of the measure- ments by the tissue waste characteristic of the disease ITS N'ATURi:, CAUSES AND PREVENTION. 99 would hardly have l)i;ei» more than three or four iucluis in each case, or not much more than half of tlie five-sixtliH shortajj^e. in Octoher, 1882, a pamphlet was ])uhlished, giving the results of my investigations in this way, from which the following is quoted : " One of the inost marked features, and perhaps the most important one, brought out in the analyses of the cases reported, is the evidence that those who die of the disease under consideration have a proportionately small pulmonary capacity — a small, contracted chest. This is shown not only in the average of the cases, hut in every case ; in not one did the circumference of the chest closely approximate that of a well- developed individual of the same height and weight. Accordinii* to tlie best authorities the circumference of the ciiest around or on a level with the nipples should he, for good development, equal to one-half the lieight, plus one -fifteenth the height, of the individual. The circumference of the chest, therefore, of one w^hose stature is 5 feet 5i inches — the average height of the cases reported — should be, according to that, at least 37 inches ; whereas the average circumference of the chest in these cases was only 3H inches, or about five-sixths of that demanded by good natural develop- ment. In about half the cases the chest was reported as flat, as well as small in circumference, a form giving still less capacity than a round chest with the same circumference. It may be fairly assumed that the average length of the cavity was not greater than in well-developed persons. In the larger proportion 1 I-' »1 100 CONSUMPTION II .1 M m i of cases the trunk was reported as proportionately long, but probably owing to a long abdominal cavity ; as in most of the cases the function of digestion appears to have been usually well performed. " Now, although small lungs may be more highl}' organized than larger ones, as often is the case with other organs — the air cells in the small lungs may be, relatively, more numerous than in larger ones, and so give a relatively greater respiratory surface — we have no evidence that this is the casj, and although this condition might prevail to a certain extent, there was, doubtless, in all these cases a marked want of capacity for the purpose of carrying on, in a perfect manner, the important function of respiration. There would be, consequently, in such circumstances, besides want of personal stamina, from want of oxygen for active tissue metabolism, a tendency to accumulations in the blood and other fluids of the body of waste, used-up matters, and frequently probably, too, of unassimilated though perhaps digested food, especially of the carbonaceous class. . . . The patients had been nearly all small or moderate eaters, and had used but little fattv food except butter. They could, for the most part, appar- ently readily digest all the system could utilize with its small respiratory capacity. " Why, it may be asked, should persons with small lungs most readily fall victims to consumption ? Many more persons, we cannot doubt, take into their bodies the germs of consumption, the bacilli, than manifest symptoms of the disease : just as, doubtless, ITS NATURE, CAUSES AND PREVENTION. 101 in the case of other infectious diseases. Besides the exciting cause of any infectious disease, there must be, before the disease can be developed, a predispos- ing cause — the seed must have favorable conditions for its development and multiplication. . . . In a healthy, vigorous, clean constitution the germs are harmless, and are probably soon destroyed, or ex- pelled from the body by the excretory organs." During the next few years after these investi- gations I gave a good deal of attention and study to" tliis factor, a respiratory want, in the causation of con- sumption, becoming yearly more and more convinced of its vital importance. In October, 1889, at the Con- vention in Brooklyn, N.Y., of the American Public Health Association, in a paper which it was my privilege to read at one of the meetings, I brought tliis special subject forward and urged the desirability of making practical application of the suggestions which it involved when employing measures for the prevention of consumption, instead of confining our chief attention to, and directing almost our entire forces against, the tubercle bacillus. EXPERIMENTS AND OPINIONS OF OTHERS. There are others who have given attention to this subject, and w^ho, from their recently expressed views, appear to entertain opinions similar to my own, especially in respect to the principle involved, as shown in the following extracts. In March, 1890, Doctor Stephen Smith Burt (at New York Acad, of Med.) said, " An acquired inse- J 102 CONSUMPTION ■> I % curity from the pathogenic germ [the tubercle bacil- lus] is due to innumerable causes which conspire to lower the tone of the system in general, and of tlu- lungs in particular. One source of structural weak- ness which has especially impressed me is that tin* waste products circulating through the organism aif ofttimes not properly oxygenated on account of defective respiration, and these form an attractive field for the harmful bacteria ; whereas, a thorough daily bath of the tissues in well-purified blood con- sumes the ptomaines, and by keeping the cells of the body in a sound condition, starves the germs that have chanced to gain admission." In a little book by G. W. Hambleton, M.D. (Pres. Polytechnic Phys. Develop. 8oc., Gt. Brit.), which has attracted some attention, the preface of which dated April, 1890, at London, the . authoi" IS writes : " I have experimentally produced con- sumption [i] by the reduction of the breathing sui- face of the lungs below a certain point in propor- tion to the remainder of the body. . . . On one occasion I took a well-developed chest, and gradual l}'^ submitted it to conditions that tend to reduce the breathing capacity, and at the same time, so far as possible, placed impediments to the performance of compensatory action by other organs. At first there was a reduction of the chest-girth, a wasting of the muscles, a loss of the range of extension, the well- known change in shape, and increased frequency of breathing. This was soon associated with catarrh, pain in the chest, steady loss of weight, and hectic ; m^ ITS NATIKK, ("Arsis AND I'KEVKXTIOX. iO.S !Ui(l the process was continued until I was satistied tluit consumption wns well estalilished [i]. Then I induced compensatory action \)y other or^^ans, and sui)niitted the lungs to conditions that tended to develijp them. 'J'ljis was followed hy great relief in tlie chest symptoms, which eventually disappeared by a restoration of tlie general health, a return to the normal weight, a change in the shape of the chest in an opposite direction ; an«l I continued the process till the chest had regaine<l its full development, and there was sound Iiealtli. Kach step in the experi- ments was car(!fully verified, the saiu se([Uence of events was invai'iahly observed, and 1 have both traced the presence of these condi< i ms andwnlohod their })rogress in many cases of consumptioii. But .ew probably would approbate l^ot ..or Hamble- t(m's experiments in their entirety. He had, doubtless, implicit faith in the certainty of his remedy. Doctor Hambleton is one of the very few who do not yet recognize the generally received theory that the bacillus tuberculosis is an essential factor in the causation of tubercular consumption. His theory, therefore, that consumption is solely produced by conditions that reduce the breathing capacity below H certain relative point, is not likely to receive general recognition. But, and although he does not inform us whether in the cases of his experiments, when " consumption was well established," there were bacilli in the expectoration, his experiments are nevertheless of considerable value, in showing the effects of a limited respiratory function. p >M' ^1' ■ mm s^BI[ Wft! Vi ';. ■" 104 C()NSIJMI»TI()N : i: '■:■':!■'. mm ^1 i^- ■ :l J. Edward Squire, M.D., M.R.C.P., etc., Physician to the N. London Hospital for Consumption, in a recent bvok (Hygienic Prevention of Connump., '98. London : Chas. Oriffin & Co.), gives the following table showing " the average quantity of air expired after a full inspiration, for different lieights, in health, compared with that which can be expelled by persons of similar height in the early stage of phthisis : Height. Health. Early Phthisis. 5 feet 5 inches. 214 cubic inches. 143 cubic inches o „ 6 222 149 M 5 ,. 7 230 1.54 M 5 ,. 8 238 159 „ 5 .. 9 246 165 .. 5 „ 10 2o4 170 M 5 .. 11 262 176 „ This points clearly to a limited respiratory capacity before the commencement of the disease. No medical fact is better known, even beyond the limits of the profession, than that a sedentary life with a stooping, lung-contracting posture, sr inds high in the list of causes of consumption ; and also that those with a narrow, flat chest are much the more prone to the disease. Why ? Again, we find the latest authorities, specialists in chest diseases as well as others, so far as their views can be obtained, universally recommending chest expansion, and so increase of lung surface and respi- ratory capacity, as one of the most important, if not the most important, of all remedial measures ; indeed an absolutely essential one, as well as the first of r preventi kinds m disease, various same obj purposes " live in benefit fi oxygen, — has ali nianded i Von Z quoted, a tuberculo to weakei fresh air The effec' prisons, ai rooms" o but rich stagnant imperfect sedentary the lungs tinues. H flat, with tion." In place. . inspiratio] or by " re\ Thomas m ITS NATURE, CAUSES AND PREVENTION. 105 jts in dews jhest fespi- not Ideed it of preventives. The pneumatic chambers of various kinds now cominor into use in the treatment of the disease, with other mechanical contrivances, and the various gymnastic exercises liave, in the main, the same object, increase of lung surface for respiratory purposes. 'The advice to " keep out of doors," or to " live in the open air," in order to get the utmost benefit from the pure air — the greatest proportion of oxygen, for both invigorating and purifying the body — has also the same object, and long and ever com- manded first place in the list remedial. Again, Why ? Von Ziemsaen, the higli German authority already quoted, after giving much the usual list of causes of tuberculosis, says, " Of all these none are so powerful to weaken the resistance of tissue cells, as the lack of fresh air and the insufficiency of out-door exercise." The effects can be best studied in the " inmates of prisons, asylums, convents," etc., the air in the "closed rooms " of which " is not pure," " is poor in oxygen but rich in carbonic acid" (like what it is in the stai,^nant air of the air chambers of the lungs in imperfect shallow breathing). " On account of the sedentary life, the respiration is not deep enough and the lungs are not well expanded," Von Ziemssen con- tinues. He describes the " paralytic thorax,"or chest; — flat, with " slight elevation of the walls in inspira- tion." In the treatment, fresh air occupies the first place. ..." The patient should practise deep inspirations," as by " climbing any hill or mountain," or by " regular gymnastic exercises." Thomas J. Mays, M.D., Philadelphia (in Pulmon. f ■ il ' il ■ :ll i 11 M 106 CONSUMPTION : I ! I^.'i Consump. a Nervous Dis. Detroit : Geo. S. Davis), after referring to defective expansion of the apexes of the lungs as being a cause of tuberculosis so often commencing there, says, " This explains why those who follow in-door occupations, who habitually become stoop-shouldered and flat-chested, furnish such a large contingency to the army of consumptives." Respect- ing the treatment, he recommends " the inhalation of oxygen, nitrous oxide and compressed air," and the practice of " pulmonary gymnastics." N. S. Davis, jr., A.M., M.D. (Prof. Med. Chig. Med. Col., Phys. Mercy Hosp., etc.), names the follow- ing, and in the order given, as the four commonest causes of acquired predisposition to consumption : Breathing of closely confined air ; lack of necessary muscular exercise ; use of food that is not wholesome : possession of other diseases of the lungs *ind tubes. Lack of exercise " prevents frequent and deep breath- ing." " If air be allowed to remain too long in the lungs it becomes over-filled with waste matter and ceases to purify the blood ; then all parts of the body begin to feel the lack of the invigoration which an abundance of fresh purifying air will give to the blood, and through it to all the tissues. ... A person quietly standing or sitting breathes less pei- minute by several inspirations than one who is walk- ing or otherwise exercising. In addition to breath- ing less frequently he breathes less deeply." In both Avays the amount of air breathed "is made to fall below the standard." When the body is bent and the shoulders sag forward, "the amount of air entering and iiw ITS NATURE, CAUSES AND PREVENTION. 107 escaping is plainly greatly lessened. A considerable part contained in the lungs is stagnant. ... Of special exercises the most important are those that expand and enlarge the chest and insure thorough ventilation of the lungs witli clean air. . . . An erect carriage should be striven for. ... In order to expand the chest nothing is so important as . . . enforced and frequent deep and slow inspirations and expirations. The necessity for such exercises cannot be too greatly emphasized. . . . Deep breathing causes better oxygenation of the blood. . . . The entire lung capacity should be brought into use. In those parts where the air is rarely changed, waste matter that should be exhaled accumulates. If disease exists near, products of the action may be re-absorbed, and prove poisonous to the body." In concluding, in respect to different forms of exercise, on which he dwells, Doctor Davis adds : " With all these exercises it is best to comlnne systematic and enforced deep breathing " (Consump. : How to prevent and how to live with. Phila. : F. A. Davis, Pub., '91). J. Edward Squire, M.D., etc., London, in the work above quoted from, remarks, — " The proper develop- ment of the chest is especially imp<^rtant in those with a phthisical tendency." Proper carriage " does much to tlirow out the chest and increase its capacity. . . . A most important effect of muscular exercise is that produced on the lungs. . . . The quantity of air inspired and of carbonic acid eliminated is thereby greatly increased. . . . Muscular action requires unimpeded respiration. . . . Many exercises may !-*;i j m^ S! -ll n :-t| ;i,:ii ill Tfw m 108 CONSUMl»TH)N I .;'i be useless or injurious. The chief aim should be to expand the chest and increase the respiratory capa- city of the lungs. ... I am confident that much benefit would be derived by those with narrow chest, round shoulders and a constitutional tendency to con- sumption by a special course of Swedish exercises." Chas. Denison, A.M., M.D., etc., of Denver, already quoted, who has had exceptional experience in the disease under consideration, asks, *' Why is it that consumption is so often * of the lungs ' ? Is it because of the non-use of certain portions of the lungs ? . . . Is it because the ordinary breathing of sedentary people removes a tenth at a time of the air the lungs contain, and those portions farthest from the large tubes are so little disturbed that they become vitiated and retractive in the self-poisoning process through which the individual passes? Is it because the bacil- lus of tubercle nee^s some such vitiated climate, be it the stagnant, imprisoned air or the chemically changed secretions, in order to multiply most pro- lifically ? . . . Settle this question ... as you will . . . you must come to the decision that it is natural elimination which is interfered with, and it is healthful respiration which is wanted. It is action as opposed to stagnation." Austin Flint recommends " increased expansion " and " forced efforts of expansion " of the chest in the treatment of phthisis. Finally, H. Weaver, M.D., in a late number of the New York Medical Journal, brings out the point very clearly when he writes, — " Every cure of phthisis ITS NATURE, CAUSES AND PREVEXTIOX. 109 is the result of an increased respiratory activity and capacity, which is directly antagonistic to the devel- opment and extension of the disease. . . . Increased vitfil capacity is the great desideratum without which there can be no cure of phthisis." By vital capacity I take it that Doctor Weaver means respiratory capacity. He quotes Doctor T. J. Mays as showing that '* apex expansion or ventilation is the most important factor in the cure of incipient phthisis ; " a condition "promoted by the highly attenuated atmosphere of high altitudes." The whole of the lungs must there be used in order to supply the re(|uired oxygen, there being less of this element, bulk for bulk, in the thin mountain air. In bovine animals we find evidence of the correct- ness of my theory and contention — that a defective respiratory function is an absolutely essential factor in the causation of consumption. We find those ani- mals bred more especially for the development of the glandular system — for yielding an abundant supply of milk, rather than for robustness or vigor of consti- tution, with well-developed respiratory organs — those animals with a relatively small chest, and in which the lungs are not much, or never fully, exercised, as by a run in the fields, are usually, if not always, the ones which succumb to tuberculosis. What does all this signify and teach ? Does it not clearly and impressively declare that there is in con- sumptives, all, a want of sufficient, healthy, active lung surface for the purposes of respiration — a want of oxygen, with a consequent accumulation in the body of waste, dead matter? t ! 1 ! \U 1 I '••I 110 CONSUMPTION 14 COHROiiOHATIVE EVIDENCE. Ill cases ill which, in certain occupationH, consuni))- tion \h cauHe«l hir^cly, primarily or remotely, by dust, the cilia are ovei'taxed, {)articleH jjjet into the air chaml)er.s, and the walls of the chambers from the irritation set up become thickened, and the respiratory function curtailed. Besides, persona working in a dusty atmosphere almost instinctively avoid deep, full breathing, and rarely fully expand the lungs. Another point bearing upon this (piestion relates to the " intimate association " existing between pulmon- ary disease and the nerves controlling respiration : the vagi nerves, one (a vagus) on each side. This sub- ject is fully discussed by Doctor Mays in his treatise, already named. One can easily understa d that any disease or injury of the nerves of an organ will influ- ence its function, and that the respiratory function is injuriously influenced by disease or injury of the vagi nerves, as clinical observation and experiments on ani- mals clearly prove. The first case reported by Doctor Mays, that of Mrs. W., who manifested "uncommon nervous s}- mptoms," early showed " want of proper expansion," and " diminished respiratory motion " of the chest and lungs, supports my theor}'. So, too. does the fact brought out in his tabulated history of cases, that " division, injury, or acute disease of the vagi always resulted in oedema, hyperaemia, hasmor- rhage [swelling, congestion or bleeding] or bronchitis, but never in phthisis— the last disease only being pro- duced when the vagi were subjected to a slow process ITS NATURE, CAUSES AND I'UEVEXTIOX. Ill of (l(5vitaliz»itioii such as would take place from lonj^- contiiuu'd presHiirt; or protracted disj^ase of the nerve." Here the " injury " or " acute distNiHe " would (piickly affect the respiration; the; "slow <levitalization," j^radu- ally curtail the reH])iratoiy function, ])roducinf( the hIow jiuisonino; process necessary for tlu; pi'oduction of the tul)ei'cular soil. Jt seems possible, too, that a stooping curved position of the chest and shoulders might cause such pi-essure on the vagi nerves at the base of the neck, where they ai*e so near to the iirm walls of the large arteries, as to interfere in a measure with their perfect function. There is yet anothei- })oint,the consideration of which also appears to give support to my view. For centuries the breathing of already <jver-breathe<l aii* has been looked upon as a most connnon and prolific cause of consumption, as already intimated. This is so gener- ally recognized that authorities.need har<lly be (pioted here: this one will suffice. In his "New Medical Dictionary," Geo. M. Gould, B.A., M.l). (Philadel. : P. Blakiston, Son & Co.), writes, " Among yet unde- termined leucomaines are l>ases known to exist in expired air. . . . The same violent poison is said to produce ])ulmonary phthisis in confined air by continuous influence." It is well known — the records of mortuaiy statistics proving beyond doubt — that the death-rate from consumption is much greater in the poorer parts of cities where the dwellings are overcrowded than in the less crowded parts. It was shown last year at the Academic de Medicine, Paris, that one poor disti-ict in » M i:l 'I, 1 ■ ■-i^-' >«'■ 'tl • !-■ ;•'. ; r.^;. ifj-^ ik^: i^ , 112 CONSUMPTION that city, tlie Plaisance, had a death-rate from this dis- ease nearly ten tiinos j^reater than the Champs Elysdes. This difference is due in a measure to other causes — want of sunliglit, improper food, and the spread of tlio disease by infection : but un( questionably the principal cause is the breathing of over-respired air in small, close and crowded rooms, — imperfect respiration. It need hardly be said that the habitual breathinjjf of an over-breathed atmosphere, outside the body, with its reduced proportion of oxygen, excess of car- bonic acid and organic poison — the " undetermined leucomaine " — gives rise to the same body condition, in a degree, small or greater according to circum- stances, as the stagnant, largely unchanged atmosphere in the air chambers within the body, arising from shallow, limited breathing. Finally : it may be asked, how is it in cases of con- sumption which are practically cured without special out-door or lung-expanding treatment, occasionally in a city hospital ? May it not be somewhat in this way : symptoms being usually nature's benign efforts towards health, and cough being a symptom curative in design, it eventually not only expels irritating sub- stances on the surface of the air passages, but also acts as a forcible distender of the lung membrane and air chambers ; acts practically in a measure as do lung gymnastics — stretches and attenuates the air chamber walls, increases tho respiratory capacity and improves the function ? The act of coughing is unquestionably remedial, and in certain cases, as in persons with a good history — no hereditary taint, ITS NATURE, CAUSES AND PREVENTION. 113 under the improved surrounding conditions in a mod- ern well-ventilated ward, the best of nutrition, anti- septics, and perhaps skin-cleansing and stimulation, tlie cough, with these remedies, at length gives rise to a reaction, or the turning-point toward health, and the cure which finally comes about. WHAT MAY BE SAID AGAINST THIS VIEW. It may be said that some persons die of consump- tion who have a well-developed chest. So far as my observation and experience have gone, they are muscular persons, perhaps even with a tendency to lay on fatty tissue, and, withal, a chest measurement large in proportion to the size of the lungs ; in other words, the lungs are not so large, perhaps not nearly, as one might naturally suppose them to be. Besides, it is possible that the lungs of such persons are less highly organized, have larger air chambers and fewer of them proportionately. Some persons, too, with well- developed lungs have a habit of very shallow breath- ing ; while the skin is often also neglected. Again, it appears there are a few so-called " ath- letes " who habitually for a time fully, probably over, exercise their fairly developed lungs, yet who fall victims to consumption. It will be found that in such men, while the lungs are fairly well developed they are not sufficiently so to bear the strain of the exces- sive amount of labor thrown upon them by the per- haps violent general bodily exercises indulged in, as of rowing, base-ball, etc., possibly thrown upon them suddenly at the beginning of the exercises : the train- 8 ifm- n 114 CONSUMPTION %' i ing, especially at the commenceineiit, being bad, tlic lungs are unable to perform, without strain, the extra respiratory work demanded of them by the increased general muscular action. They consequently break down. Hfiemoptysis (spitting of blood from the lungs), if not more profuse bleeding, is the probable conse- quence. The bleeding is probably not caused l)y tubercle. Eventually, however, with the consequently restricted respiratory action and capacity usually following this condition, tubercles are formed. RESPECTING CAUSE AND EFFECT. There are scientific physicians of high standing who do not yet believe that the tubercle bacillus is tlie cause, or a cause, of consumption ; but that it is always present as a consequence. The truth appears to lie between the two views. The bacillus will not grow and multiply in the body, or the tubercular matter characteristic of the disease be produced, unless there be already in the body a certain condition or substance — a "soil" — practically and actually body derangement — disease. As a limited respiratory capa- city seems to invariably precede the tubercular state, what explanation so natural and reasonable as that this deranged condition of boily — this so-called soil — results from excess of waste — debris of tissue wear and combustion — accumulated in the body by reason of the imperfect respiration ? This waste in decomposing would doubtless give formation to such inorganic elements as would be suitable food for the vegetative microbe. And as something more than simple food if iliili , ITS NATURE, CAUSES AND PKEVEXTION. 115 seems necessary to give rise to the virulent patliogenic action of the microbe (else most likely more persons would be affected by it and it would not remain in the body in a dormant state or be found in a hannless con<lition), the decomposition of the excess of waste, in the absence of abundance of oxygen, too, also gives rise to some more special soil-fitting substance, plus the inorganic food elements; something toxic to either tlie body fluids and tissues or the bacillus, or to both, and which transforms the V)acillus into virulency : somewhat as the bacillus coli connnunis is transformed 1)V " cultivation "tin " fecal solutions " ; or as other toxines sometimes formed in the body, it appeai-s, give rise to headaches, " malarial " sj'^mptoms and even epileptiform convulsions, possibly, too, through the action of micro-organisms. While, on the one hand, then, there can be no tubercle without the tubercle bacillus, so, on the other, it seems probable there can be no tubercular consump- tion without the previous excess of waste in the body from imperfect respiration. The bacillus is a natural organism ; the defective breathing and excess of waste in the body constitute an unnatural condition, which exists previous to, and seems to be the cause of, the virulent action of the bacillus : if so, this abnormal condition, rather than the bacillus, is the actual exciting cause of consumption, an 1 in pi-eventive action, demands first consideration. Moreover, were these bacilli at once all annihilated, those persons pre- disposed by such condition to harbor them, would not probably remain long in any better state than if l^B^ IB 116 CONSUMI»TI()N : |l'< ■'!■ It , 'I subject to the depreciations of the bacilli ; other germs would most likely soon invade the inviting field : a point to be again touched upon. CONCLUDING FACTS AND DEDUCTIONS, What are the now generally recognized facts which bear upon this subject ? They appear to be, briefly, about as follows : 1. That the tubercle bacillus is an essential factor in the production of tubercular pulmonary consump- tion. 2. That the tubercle bacillus does not become a cause in the production of the tuberculous state, except in a special condition of the human body — in what is termed a suitable soil. 3. That the tubercle bacillus, being ubiquitous, is doubtless often received into the human body, and is apparently sometimes retained there an indefinite time and yet produces no ill eft'ects, because the body con- dition — the so-termed soil — is not then suitable for its virulent or pathogenic action. 4. That this apparently quiescent, non-virulent state of the yet living bacillus cannot be satisfactorily explained on the supposition of an immunity by rea- son of phagocytic action, or bactericidal properties of the blood serum ; nor especially can the later activity and virulence of the bacillus, on the supposition of only weakened phagocytes or want of the serum antidote. 5. That the virulence of pathogenic micro organ- isms may be and is increased, and benign micro- ITS NATUHE, CAISES AND IMIEVEXTION. 117 oi'j^aniama rendered pathofjenie, by certain special circumstances of condition or environment ; or, in oilier words, and more definitely, by bein^ brought in contact with, or under the immediate infiuence of, certain substances, perhaps in a measure toxic, in either a living animal body or outside of it, as in cer- tain decompositions of excremental matter in the case of the bacillus coli communis. G. That certain substances, such as ptomaines and other toxic combinations, are formed in the human body by the chemical or physiological changes or decompositions which take place therein in accumula- tions of used-up, dead, excrete matters; and doubtless these ^ xic substances exert an influence on micro- organisms, whether benign, saprophytic or pathogenic, which are present in the body. 7. That a want of full proportional breathing sur- face or action necessarily gives rise to accumulations and excess in the fluids and tissues of the body, as well as in the lungs, of used-up, effete products of the functions of life, which, with full respiratory action, would be thrown out. 8. That as oxygen appears to neutralize or destroy the effects of ptomaines in the body, and probably prevents their formation, the want of oxygen conse- (|uent on a defective respiratory function, doubtless favors the production of intoxicating ptomaines from accumulations of the waste products of life. 9. That, therefore, persons with defective respira- toiy action from any cause are more liable to have 'iff ■ iiitf ill i^r |7 118 (!ONSUMI»TIO.V > I toxic HubHtaiices formed in the body ; and which pro- bably inrtiienee the action of micro-organisms present therein, inchiding tubercle bacilli. 10. That the acti(in of the bacillus, which results in the formation of tubercle in the lungs, seems to hv invariably associated with a want of full proportionate breathing function in the individual afi'ected ; or, in other wor«ls, the so-called soil for the pathogenic action of this bacillus in the lungs seems to be invari- ably furnished by persons with a defective breathing function, as particularly evidenced by the success of the " out-door " or " pure-air " treatment of the dis- ease, with special lung expansion for increasing the breathing function, almost universally recommended. It has l)een my endeavor not to take a narrow view of this (juestion, and I do not advance the theory that I' <lefective respiratory function is the only cause of consumption ; but in consideration of all the facts it is a fair and reasonable inference that in persons witli this function reduced below a certain relative or pro- portionate healthy limit, there are eventually accunm- lations in the body of waste, dead matters, the decom- position of which, while probably providing inorganic food elements for the tubercle bacillus, also at the same time gives rise to a certain toxine, which, either directly or through the tissues, so affects the bacillus as to render it poisonous and destructive of even fairly or practically healthy tissue. The formation of tubercle in parts of the body other than the lungs would readily arise in the same manner, from the same cause ; the germ food elements l; lafei a ITS NATUllE, Ci^lISES AND PREVENTION. 119 aufl exciting toxine pervading the entire body. The (liseaHe would be, liovvever, naturally less frequent in other parts than in the lungs, the immediate seat of the defective function and source of the exciting cause. Have I not novv fairly demonstrated, on the strongest circumstantial evidence, as intimated in my pamphlet of thirteen years ago, that a defective rt'spii-atory function with the consequent retention in the body of waste or excrete substances and the toxic compounds generated thereby, is the actual, immediate or exciting cause of consumption ? It can hardly be doubted that, imperfect breathing — defective respira- tion—gives rise to excess of waste products in the blood and tissues ; that the waste })roducts decompose and give rise to toxines ; and that the toxines cause general bodily depression — languor, even want of ap- petite with dyspeptic symptoms, and, eventually, loss of body weight, — the too familiar pretubercular state. Thiy condition is brought about slowly in many cases, more (piickly in others. What more fitting condition, or soil, than this for the action of the microbes, or so-called germs, so far as we now know the nature of these ? What condition more likely to cause dor- mant, non-virulent microbes, or saprophytes, to be- come virulent — rapacious — parasitic, pathogenic ? The other causes, yet to be discussed, for the most pai't, but favor imperfect breathing. I i; ' r, ' ^A il ; CHAPTEK V. CAUSES OF CONSUMPTION CONTINUED. HEREDITY AS A CAUSE. (5ENERAL HEM AUKS. The subject of heredity i.s one which ha.s been in a large measure niiaunilerstood, or about wliicli tliere has been much miscompreliension. Sonie lieredi- tary influence l\a.s lony* or " always " been reg- "'UhI as a cause of consumption. Take ahuost any Cc.. of the disease in a man or woman in early or middh' life, and ask a hundred neighbors the cause of it, referring to that particular case, and nearly every one of them will reply, in efl*ect, that it was inherited. And it is undeniable that the disease is more com- mon in certain families or strains than in others. As already has been stated herein, however, less impor- tance is now attached to heredity as a cause than was formerly the case. Previous to the discovery of the tubercle bacillus, heredity was supposed to be limited to the so-called predisposition or susceptibility — to some sort of " idiosyncrasy " — a peculiarity of constitution or tem- perament, to that condition now regarded as a fitting soil for the growth of the bacillus. Even then, how- ever, children of consumptive parents were said to ^^■'^ twk" .'Si M- m- 1 m m 1 m Mi' i.i ITS NATUIIE, CAUSKS ASU rM{EVE\TI<)\. 121 inherit the " Heeds of the disease " : yet this doubtless without any specific or particular seeds, as now known and understood, being generally c^ven sus- jx'cted as a cause. Since Koch's discovery the (ques- tion has been nnich discussed as to whether or not it he possible or common I'or the bacillus or its spores to i)e directly conununieated by the parent to the ort'spring. Can the specific living germs, the so- culled seeds of the disease, be inhei*ited ^ After giving some statistics reflating to heredity in jri'iieral, we will consider the subject in its two phases: first, tlu; influence of heredity, as it relates to the transmission of the bacillus itself: and, second, as it relates to the predisposition or idiosyncrasy. STATISTICS HEAI{IX<J I I'ON HEKEDITV. Statistics, for the most part, asides from reports of actual events, as births, deaths, etc., are often falla- cious and misleading, and but rarely interesting, or only interesting to a small minority of persons. It will be well, however, to give a few here in order to illustrate in a general way the extent of hereditary influence. Statistics })earing on this subject show on an average that in about one-third of the persons affected with consumption there is a possible chance that it was in a measure inherited from parents. Mays, in his work already referred to (Consump. a Nervous Dis.), quotes interesting comparative statis- tics fiom the report of the N. Y. Mutual Life Ins. Co., for 1877, which show that, of 1,031 cases of con- sumptives and an ©(pial number of non-consumptives, 122 CONSUMFriOX ill . . I'm: ■ m there were among the former 194, and among the latter 102 family members who were tainted with the disease. It may be observed in respect to these, however, that if an equal number of other persons of each class were selected, (juite different results might possibly be deduced. Williams (Pulmon. Consump.) mentions 1,000 con- sumptive cases of the Brompton Hospital Report, including only heredity from parents, which gave an average of 24.4 per cent, in which there was heredi- tary influence ; 385 cases by Doctor Fuller, em- bracing also grandparents, uncles and aunts, which gave 59 per cent.; 1,000 cases by Doctor Cotton, embracing parents, brothers and sisters, which showed 36.7 per cent.; and 1,200 cases by Doctor Pollock, similarly estimated, showing 30 per cent. Doctor Williams' own cases, 1,000 in number, on the same basis as the latter, gave a percentage of 48.4. Squire, in his recent work, already quoted from (Hyg. Prevent, of Consump.), makes the following statements respecting cases of his own : " The figures obtained in the ordinary manner probably give far too high a proportion in favor of heredity. To take a few illustrations from my hospital case-book : Out of 500 consumptive patients, one or both parents had been consumptive iii 154 cases, showing possible heredity in 30.8 per cent., and no phthisis in the par- ents in 69.2 per cent. This gives a possible chance of heredity in about one-third of the cases; and this amongst hospital patients whose mode of life is unfavorable and unhygienic. In 250 of these cases, mil). ITS NATURE, CAUSES AND PI{EVENT1()N. 123 ill which the family history is more fully stated, one or both parents were consumptive in sixty-two cases, or only 24.8 per cent. In these sixty-two families the total number of children amounted to 374, of whom 108 became consumptive — again about one-third. Here we are only dealing with families in which consump- tion has shown again in the second generation, so the proportion is higher than it should be : for if we could include the families of consumptive parents where all the children have escaped the disease, the numl)er of individuals w^ould be increased whilst the nundoer of consumptives would remain the same. " In the above sixty-two cases, tlie father was con- sumptive in twenty-eight cases, and these twenty- eiirlit families Contained 185 children, of whom forty-three became consumptive, or about one in four. In twenty-four other cases the mother was consump- tive, the total number of children was 152, of whom forty-seven became consumptive, or nearly one in three. In the remaining ten families both parents were consumptive, the total number of children was tliirty-seven, and of these eighteen, or nearly one-half, became consumptive. " This is a small number of cases on which to found general deductions, but they seem to show that where the mother is consumptive, the hereditary tendency to the disease is slightly more intense than when the father alone is phthisical. When both parents are consumptive, not only is the number of children much reduced, but the hereditary tendency is increased. Against the theory of hereditary predisposition in i-! ill; mi 124 CONSUMPTION : these cases we have to remember the closer connection of the mother with her family both in infancy anu in sickness ; " — and a possible chance of infection, he doubtless hints at. Some statistics have sliown that nearly twice as large a proportion of consumptives have tuberculous brothers and sisters as have tuberculous parents. This of course points to other causes — habits and conditions of life and probably infection. The following concluding quotation is from my own pamphlet, published thirteen years ago, already referr- ed to (Etiolog. Statis. Rep. on Causes of Consump.): " It appears, therefore, that any special influence or matter of a direct or specific hereditary character, as a factor in the causation of consumption in adults, or even in youths, is not of such constancy and impor- tance as has been commonly supposed. In only little more than one-half (53 per cent.) had any relatives been known to have died of the disease ; and in not much more than one-third (3G per cent.) had any ancestors — parents or grandparents — died of it. More than this in favor of heredity could doubtless be said of scarlet fever and measles. But, in so far as con- figuration and structure of the body and the relative size and vigor of diflferent organs are influenced by parentage, hereditary influence becomes an important causative factor. Indeed, heredity probably has no direct influence whatever at the periods of life above mentioned other than in this way. ITS NATURE. CAUSES AND PREVENTION. 125 HEREDITY AS RELATING TO THE TUBERCLE BACILLUS. On this point of the subject there is still a differ- ence of opinion. The greater weight of authority is altogether on the side of those who believe that the bacillus may be, but very rarely is, transmitted from parent to child, and that the infant may come into the world with the actual living germ already in its tissues. There seems now to be the most convincing evidence of this. As Ziemssen has said, tiie great difficulty connected with the question lies in the "long latency of taherculosis in childhood" — its long dor- mant or concealed state. Baumgarten, it is said, has in the case of the rabbit observed the bacillus within the ovum ; and Jonne, of Dresden, in an unborn (foetal) calf of seven months intra- uterine (in the womb) growth, found numerous tubercles, showing that if the ovum had not been infected, the bacillus must have passed through the placenta (after-birth) of the mother. Again, it appears that experiments of inoculating healthy animals with juices of unborn animals from tuberculous parents have been made which favor the view that the bacillus or its spores may pass from the mother to the unborn offspring. Solles believes that direct hereditary tuberculosis exists by means of the sporules passing in this way. In 1891, Birsch-Hirschfeld reported the case of a woman dying of acute general tuberculosis at the end of the second month of pregnancy : careful examina- tion revealed numerous tubercle bacilli in the after- birth ; and portions of the liver, spleen and kidney of the unborn offspring transplanted into the abdominal 1 m nwT 126 CONSUMPTION : 'l':vi. cavity of guinea-pigs and rabbits produced undoubted tuberculosis. Baunigarten, in a more recent article, supports tlie view of direct hereditary transmission, and claims that the bacillus is present at birth in many of the children born of tuberculous parents, but that it is latent, and "its future history is depen- dent in a great measure upon the favorable or unfavorable condition of the soil offered by its host." It may in time, he thinks, " lose its vitality ; " or, on the contrary, under depressed conditions of the sys- tem, " take on luxuriant growth." A conclusive case, obsers ed by F. Lehmann, has been recently published (Berl. Klin. Woch., July 9th, '94: Brit. Med. Jour., Dec. 1st, '94). A mother, aged 40, who had been long phthisical, gave birth to a child, and died on the third day thereafter. The lungs " showed old tuberculous disease and miliary deposits." Tlie child died twenty-four hours after birth. Its lungs, bronchial, mesenteric and other lymphatic glands and a kidney were tuberculous. Birsch-Hirschfeld, and, later, Kockel and Lungwitz are inclined to the view that the way in which the bacilli pass from the mother to the foetus is by " grow- ing through " the after-birth ; i.e., apparently, by the gradual spread of the disease through it. On the other hand, Davis, quoted on a previous page (Consump. : How to Prevent, etc.), says, " From the facts gathered, we must conclude that the bacilli are not transmitted to offspring by tuberculous fathers, and that, while it is possible for such trans- niission to take place from tuberculous mothers, it ITS NATURE, CAUSES AND PREVENTION. 127 occurs with the greatest rarity. The disease is hereditary, because there is transmitted a predisposi- tion to it, not the bacillus tuberculosis." Professor Blackader (McGill, Montreal) says, " Pathologists now tell us that heredity in this i'orni i.s the very rare exception. In the vast majority of cases heredity in tuberculosis signifies only an excessive hospitality for the tubercular microbe, or a deficient capacity for dealing with it on the part of a too feeble phago- cyte. ... It may be said, that the view generally lield is that cases of true heredity are extremely rare, but that instances may occur, as where the mother is suffering from general miliary infection or from definite tuberculous disease of the genital system." Epstein, in two hundred infants under one year of age, of tuberculous parents, could not find, upon examination, signs of tubercle in one. In respect to animals, Osier (Practice of Med.) states that, " although, in Berlin abattoirs for some years past, 13 per cent, of the animals slaughtered were tuber- cular, out of 15,400 calves killed, only four were found similarly diseased." Professor J. E. Graham (Toronto University) asserts that the baby guinea- pigs of tuberculous mothers are never found to be affected ; and at a large maternity hospital in Paris (Clin. d'Accouch.), post-mortem examinations were made in all cases of death of premature or fully developed children during a period of eight years, and tuberculosis was never found ; nor had inocula- tions mr«,de been successful. It may then be stated that actual heredity in this TT m if? ^i I 128 COXSUMPTION : sense in pulmonary consumption, as ordinarily seen in youths and adults, is practically not known. In young infants tuberculosis is nearly always chiefly in the glandular system or brain membranes, the lungs being little or perhaps not at all attected. And although the inherited bacilli or their spores nmy not infrequently lie dormant or latent in the tis?"ies for a long period of time, as some authorities believe, it is not likely they would so lie for years and first mani- fest virulency in children of even a few years of age. HEREDITY AND THE BODY FACTOR OR SOIL. As already intimated, that which is- inherited in this disease is usually the constitutional build, or configur- ation, or the tissue structure, wliich favors the develo])- ment in the body of that which enables or incites the bacillus to take part in the production of tubercle. In other words, it is that which gives rise to the so- called soil ; or prol)ably, sometimes, the suitable soil itself — the deteriorated, or even foul, poisoned fluids and tissues, and perhaps ^' feeble phagocyte " cells and weakened germicidal properties in the blood. It is natural for parents to transmit to the off^spring peculiarities, even defects, of form and tissue condi- tion, and even of the digestive organs, of the heart, of the lungs, of the nervous system ; but it is unnatural for them to hand down to their progeny the actual living germs of disease. It would seem as if nature, abhorring this, stopped short of it, or almost stopped, and permitted it only in a few extreme cases. It is chiefly because of the inheritability of peculi- arities and defects of constitution which are in a lift' ■'< IP M: ■wm ITS NATURE, CAUSES AND PREVENTION. 129 measure favorable to tlie development of eonaumption tjiat the disease has been lonj^ regarded as hereditary. When heredity in this disease, or indeed in any other, is spoken o", usually the reference is made to an inherited tendency to it ; which may be very marked or strong, or very slight. There is a measure of heredity in many, if not all di.seases. It is well known, for example, that a tendency to insanity — a defective ])rain structure — is inherited, and also, to heart disease ; or it may be only a proportionately small heart that is transmitted, which by reason of this defect the more readily becomes diseased. Cancer is believed to V)e, in a measure, hereditary. And some families are much more disposed than are others to " take," and to have in a more virulent and fatal form, even scarlet fever, measles, and the like. It is because of the exceptional frequency and fatality of consumption (fatality usually from early neglect) that heredity in it attracts more attention. It is, however, certain that, as W. Roger Williams, F.R.C.8., writes it (Brit. Med. Jour., Sept. 22, '94), morbid conditions are never reproduced in the ofi- spring with the same constancy that normal condi- tions are. " All diseases tend to die out in trans- mission." " So great is the preponderating influence of the previous ancestral balance that even in families where hereditary tendency to disease is strongest, most of the members usually escape," The influence of heredity as bearing more especially on this part of the subject is summed up from opinions 9 i ■ r ' »; ^jffi" 130 CONSUMPTION of " leading biologists " by Doctor Geor^'o Wilson, in his standard work on Hyj^iene, as follows (Handbook of Hyif. London : J. Jt A. Churchill) : " The inHuomc of both parents on the bodily constitution of the ufi'- spring is manifested in personal resemblances, such as stature, similarity of features, walk, gesture, color of hair, etc. Some of the children may bear a greutiT resemblance to the father, others to the mother: but it is rare to meet with any instances in which sonic distinctive characteristics of both parents cannot Ijo traced. The influence of the other more immediatt; progenitors on the bodily constitution of the ottspriii<f is manifested by the resemblances which constitute the phenomenon known as atavism, which may lio explained in this way : — A man, for example, dcu-s not inherit all the characteristics of either his father or his mother, and of those which he does inherit, only some are developed, whilst others remain latent, and are probably developed in a brother or sister. His son, however, may in turn inherit the same char- acteristics, but with this difference, that those whicli were latent in the father become fully developed in him, so that he comes to bear a stronger resemblance to a grandparent or some other relative, as an uncle or aunt, than to Ids father or mother. — (A Physician's Problems, by I) >ctor Elam.) The influence of race, or special type, in heredity, is manifested by the con- stancy of averages, under tolerably constant condi- tions, from generation to generation. . . . Devia tions from these averages or from the normal type, although transmissible, cannot transcend certain lim- its. As all forms of deterioration or disease may be ITS XATUHE, CAUSES AND IMIEVENTION. 131 rejrariled as deviations, or yuTvorttMl life-processes, they are likewise subject to limitation in transmission, an<l there is the same tendency exiiibited to revert to normal type under improved conditions. Thus, all chronic diseases api)ear to be transmissible either as a morbid tendency or in their general form, such diseased heritage being well exemplified in the case of gout, scrofida, phthisis, syphilis, and insanity ; but by adopting suitable measures, the disease may be finally eradicated from the family, or the morbid tendency be overcome. . . . Any particular char- acteristic, especially if it be of the nature of a deterioration or taint, when common to both parents, is liable to be intensified in the offspring. It is on this account that marriages between blood-relations are inadvisable, inasmuch as latent morbid tendencies, should they form part of the organic patrimony of the family [and only in such case], are almost certain to become developed in the children." In consumption, the most noticeable and commonly inherited feature is the " flat chest," the proportion- ately small chest. This is universally recognized. With this defect, the lungs, and hence the respiratory function, can hardly be otherwise than restricted and not sufficiently developed for the needs of the organ- ism. With it, unless it be corrected or modified, too often eventually follow tlie usual consequences already depicted. With it we usually find the other signs already enumerated herein in connection with the remarks on predisposition, — the slender body and limbs, the delicate tinge, the want of general vigor : sometimes the more intense, " scrofulous " condition — a [s t 132 CONSUMPTION : liii ''Mil tendency to inflamed eyes, an irritable state of tlie nostrils and npper lip, perhaps a swollen appearance of the countenance and pasty skin, with slu|(f(isli, indolent habits: all apparently manifesting a want in the hody of oxygen with its invigorating, purifying effects U|)on the tissues and fluids and life procosscs. As already stated, what the precise nature of this predisposition — this germ fertilizer or intoxicant — is we do not yet know. Without attempting to enter further into the subject here with a view of obtaining a satisfactory explanation of it in the present state of our knowledge, or rather want of knowledge, of the remarkably intricate and delicate physiological and chemical changes which take place, and the combina- tions of matter formed, in all the various processes of life constantly going on in the human organism, in both health and disease, and the relations of these changes and combinations to living micro-organisms, whether benign or otherwise, in the body, the question may be asked, — are the tissues and fluids of the newly- born infant defective, or " debased," from a want of completeness in structure — a want of some necessary condition or element — or do they besides or along with this contain something of a debasing character, some practically foreign, toxic substance, incompatible with perfect, healthy function ? The young creature while yet in the mother's womb, is entirely nourished through and by the blood of the motlier. If this blood be debased by any impurity or poisonous sub- stance whatever, the blood and tissues of the infant when born will be, doubtless, debased in like manner. As the blood and tissues of the mother are, so will be ITS NATUHE, CAUSES AN!) I'KEVEXTinN. 133 the blood and tisHues of the infant at birth. This affliction upon the innocent ort'spring seems hard; yet tliere is no room to doubt that it may occur. And this indicates the ^reat, serious, indeed criminal, responsibility which may be placed upon imprudent parents. Statistics given by Doctor Sijuire, recently quoted, show that there were over thirty per cent, more consumptives in the families when the mother was consumptive than when the disease was only on the father's side ; yet for many and obvious reasons the father must be held at least ejjually responsible. It is, withal, comfV^'ting to know that there is a tendency in all defective living organisms to revert — to turn or change back— to the normal, healthy type, indeed, under improved or favorable conditions, apparently a tendency to improvement and greater perfection of type ; therefore, all evil hereditary con- ditions and tendencies may be overcome and practi- cally eradicated, and that, too, in a large measure in a comparatively short period of time. The principal evil in inherited predisposition to consumption, that of a defective respiratory function, with the usual accompanying conditions, may be, in the less marked cases, often overcome entirely in a few months. By means of proper special exercises in a pure, cool, invigorating atmosphere, with abundance of sunlight, the lungs and chest will gradu ''iy d,nd per- manently expand, and the respiratory function become more perfect, the muscles of the body and limbs increase in size and firmness, the complexion improve, and the weakly condition of the whole organism will give place to more general vigor. In the worst so-called WM ym'^ ll : ]U t i ■ 134 COxXSUMPTION scrofulous cases the improvement will not be so rapid and marked, but by proper managjement, the process of purification and invigoration will go on gradually to the establishment of fair health and vigor. It need hardly be stated that, on the other hand, inherited tendencies to disease may be very easily and rapidly intensified by unhygienic habits of life. It nnist be remembered that this predisposing con- dition, when not in any degree inherited, may be ac(juired by unhygienic habits and surroundings. It is acquired gradually, and may be originated in its worst form in two or three generations. A few years of one generation may be sufficient to largely reduce the breathing capacity and bring on a train of other evils. An acquired predisposition may be overcome and removed more easily, or in a shorter period of time than that which is inherited. Any reader, then, who has had relatives die of con- sumption, and feels, even in a measure, doomed to the same sort of an end, may fairly regard the possession of any possible hereditary taint in the light of simply a timely warning to use reasonable precautions for preventing the disease. With such precautions there is practically no risk of such a life- ending for anyone. It is only those who are indifferent or do not adopt and continue to practise habits of a preventive charac- ter who fall victims to consumption. Yet it must not be concluded that one who inherits the predisposition, however slight, should think lightly of it ; it should not, however, be a source of any measure of anxiety ; simply an incentive to the exercise of due care of the body. ■"^V CHAPTER VI. CAUSES OF CONSUMPTION CONTINUED. WANT OF THE NATURAL BODY DEFENCES AS A CAUSE. THE PROTECTIVE WALLS.' The provisions for the protection of the body from all forms of disease are remarkable. Not the least so are the provisions for keeping out, of the body the germs of infectious diseases. The structure of the outer protective covering of the body — the skin — is sufficiently well known to most persons. Most persons, too, have observed reference to " the skin without and the skin within," and know that the irnier cavities of the body are provided with a similar protective covering, or lining. Not only is the digestive canal, from the lips throughout, so provided, but so also is the pulmonary or air cavity. All the bronchial tubes, great and small, and the air chambers, as already stated, have the inner or more exposed air surface of the mucous membrane lining their walls covered over by a layer of cells, called epithelium, similar to the cuticle — the skin's outer layer — except that it varies somewhat in structure (as does this layer in other localities) and is moist and soft instead of dry and hard, as in the case of the skin. U . y 136 CiJNSUMPTION 1* 'i liim •', ^■■<'\ " '■ :■■(.' Pi*- ml ,1 I I .^i-' if Now, it seems very unlikely tliat living, disease- producing micro-organisms, infinitesimal as they are, can get into the body through the skin if this be sound — whole, healthy, vigorous and active at every point — if it do not present even in its outer cuticular layer any break, opening or weak spot. Hence, the neces- sity for a break in its integrity in vaccination. The "pores" of the skin having an action, a sort of current, from within outward, would hardly take in living germs ; and should these germs make an entrance, is it probable that they would get through the sweat glands Jive ? So, also, a perfectly healthy, vigorous layer of epithelium on the skin within will almost certainly prevent the passage or entrance of disease germs into the body. It is believed there must be a break, a want of continuity, in this protecting wall or the germs cannot get through. A few authorities, it is true, believe that germs may pass through appar- ently healthy epithelium and tlie other parts of the mucous membrane : as, for example, the tubercle bacillus into the lung structure. On the other hand, high authorities believe differently, and reasonable probability is on this side. Respecting the germs of diphtheria, W. H. Park, M.D., in an exhaustive paper, a " Clinical and Bacteriological Study " of diphtheria (New York Med. Rec, July 30th and Aug. 6th, '92), says, Whether this (the diphtheria bacillus) " can be implanted on the normal mucous membrane in man is still a question. Undoubtedly a lesion favors it. When the bacilli are implanted on the normal mucous membranes of susceptible animals, they do not grow." Doctor A. Jacobi, of New York, says (at N.Y. Acad, of ITS NATURE, CAUSES AND I'REVEXTIUN. 137 Med.), " Very seldom does any form of contagion, not even diphtheria, arise without there being previously a broken skin or mucous membrane. . . . Tuber- culosis of the intestinal tract almost always gives a preceding history of neglected diarrhoea." He also urges that by reason of the many sources of exposure to the tubercle bacillus, more special attention should be given, especially in the case of children, by both parents and physicians, to catarrhal conditions of the air passages and intestines, sore mouth, diarrhoeas, etc. It is, therefore, easy to see the importance of keep- ing these protective coverings of the body as intact as possible — in a healthy, vigorous condition. Any break or want of integrity, even a weak spot, espe- cially in the epithelial covering of the bronchial tubes, may open a way for the tubercle bacillus to enter. It is very desirable, too, it may be here observed, to keep the surface of these membranes as clean and active as possible. In the case of the skin, for example, as being more directly under the control of the individual, if it be unclean from want of repeated washing or bathing, disease germs may adhere to it at some point. And here they may lurk, as it were, waiting for an opportunity to effect an entrance. A break in, or a weak or foul — unclean, condition of, these protective walls may therefore be- come a cause of consumption, in predisposed persons. THE PHAGOCYTES AND BLOOD-SERUM ANTIDOTE. When disease germs do get into the deeper tissue structures of the body, whether through a weak spot or break in an investing membrane, or otherwise, if Hi EH!' w I ' J 138 CONSUMPTION the body be in a fairly healthy condition, it is not even then all free and unobstructed foraging for the invaders. They are promptly met by a sort of stand- ing army of blood cells, the peculiar protective cells already mentioned in connection with the allusion to the thistle point in the skin. Further, the very atmosphere within, so to write, a germicidal condition or property of the everywhere pervading blood-serum, may depress and weaken the germs. Four hundred years before our era, Hippocrates apparently first drew special attention to a natural protective and curative force within the human body, upp\ ' ig to it the Greek term, j)hiisis, nature ; the vv^ raedicatrix natura of the Latin and later ages. Two ii,nd a hf-H' centuries ago, the discerning Van Helmont advanced the theory of a more definite power in the body, which he personified as the "Archceus" or "Grand Regulator," whose throne was the stomach ; Wepfer designated a like power as the " President of the nervous system " ; and the bold Stahl attributed such an influence " directly and entirely to the rational soul, diffused over the whole body." Only a few years ago, Doctor Elias Metschnikoff* (Pasteur Inst.) furnished before our wondering eyes, under the micro- scope, satisfactory evidence that certain of the colorless blood-cells, or corpuscles, which he termed phagocytes, are special defenders of the body tis- sues from the inroads of the destructive or specific disease germs. Like other colorless cells, or leuco- cytes, in the blood and other animal fluids, these phagocytes are microscopic, jelly-like masses, either ITS NATURE, CAUSES AND PREVENTION. 139 globular or irregular in form, indeed often changing their form (amoeboid — polymorphous), without an investing membrane, and capable of motion. In that little animal, the water-flea, may be wit- nessed actual combats between the phagocytes and pathogenic germs inoculated into the animal. The phagocj'tes at once attack and devour the intruders, — take them into their jelly-like body and digest them. When a germ is too much for a single cell or phagocyte, others unite — coalesce — with it, and form a larger or " giant cell," which then struggles more successfully with the invader. If the phagocytes overcome the germs, the water-flea lives ; if not, the ^erms soon multiply, overrun the little creature and it dies. In the liver and intestines of birds that have died from tuberculosis, the microscope reveals, within little masses of tubercle, a cluster of minute tubercle bacilli occupying the centre of a giant cell : as, indeed, in the formation and structure of tubercle, as already explained. Doctor J. Bland Sutton compares the action of this cellular army of defence in the body to that of a hive of bees : " When an intruder is small it is quickly stung to death and cast out; when large, after being killed, it is prevented from giving further trouble [as from decomposition] by a covering of wax." Around large foreign substances, tuberculous or other, in the body, the phagocytes often form a dense fibrinous covering or wall which protects the body from further injury by its presence : as men- tioned in the discussion on the nature of consumption and the conditions of tubercle as sometimes found in the lungs. MimHtlti^' 140 CONSUMPTION • Most authorities now accept the theory of Metsch- iiikofF, although some are of opinion that the actual germicidal or germ-killing power is in the blood, or blood-serum (the watery part of the blood); which when in a healthy condition, they hold, destroys the vitality of the disease germs, while the phagocyte cells act as scavengei's and remove, destroy or cast out the disabled invaders, as other leucocyte cells remove other useless or waste excrete matters. The truth probably lies in a measure between these two views. Healthy, " undefiled " blood is, doubtless, unfavorable to the life of disease germs. The experi- ments of distinguished investigators have made this apparently clear. We know, however, that through- out nature some forms of bacterial germs are actually destructive of other forms, and it is fair to conclude that the higher organized bodies contain within them- selves special living structures or cells capable of destroying foreign ones which may gain access into the body. Doctor Adami, of Montreal (Discuss. Internat. Cong, of Hyg., Lon., 1891), says that those who are not in the thick of the controversy (as to the two theories) " must accept both views." It was, he said, " especially around the phenomena observed in the rat " that the difference of opinion had arisen. In the rat, phagocytic action " could be but with diffi- culty observed, and the rat's blood-serum possessed bacteria-killing properties in a high degree ; " and " if we directed our observations aright, it would be impossible not to be struck by the prevalence of phagocytosis." The British Medical Journal (March 26th, '92), in an editorial, says, " There is not the ITS NATURE, CAUSES AND PREVENTION. 141 slightest difficulty in proving, as Metschnikoft" lias done abundantly, that the auKieboid cells of higher animals actually pursue, attack and engulf living bacteria, which they proceed to kill and to digest." Perhaps the most i)ractical, and not the least inter- esting, part of this subject of natural protection from the action of the pathogenic microbes is in the fact that, in certain conditions of the body, effectual pro- tection is not afJbrded. The efficiency of the phago- cytes appears then to be wanting, and the germs are more likely to gain the victory — to over-run and destroy the life of the organism. This has been shown by experiments on the lower animals. Mice under the influence of chloral, for example, are the more liable to " take " infections and succumb to disease germs. Guinea-pigs and rabbits dire'ct from the grassy fields remain healthy after inoculation with virulent germs, while those confined for a time in cages succumb. The want of respiratory expansion from exercise in the open air, with the less pure air of the cages and less natural conditions generally, while providing bacterial nutriment and stimulation, probably depress the phagocytes and neutralize the antidotal properties of the blood-serum. We have already seen, in the explanation of the conditions of the lungs in consumption, that the pro- tective forces of the invaded body continue to be exer- cised, to fight, even to the death. The defensive war is pushed on as long as the life of the invaded lasts. Apparently the defensive forces continue to do their best in the contest in various ways, and without cessa- tion, to the end. J F' f J.- ■ , W m CHAPTER VII. II Mi 'cii :i ■■■r :# CAUSES OF CONSUMPTION CONTINUED. REMOTE OR SECONDARY CAUSES FROM HABITS AND CONDITIONS OF LIFE. A LARGE number and variety of causes or conditions help, in a small or (greater degree, to give rise to a predisposition to consumption. These appear to produce their effects mainly by a reduction of the respiratory function. They may .be enumerated as follows : Impure air, from any insanitary condition, but more especiallj'^ prebreathed air, from want of ventilation, or overcrowding in enclosed places ; want of sunlight ; improper diet, as unsuitable or excess of food ; certain occupations, causing dust, stooping, etc.; overwork, mental or physical ; deficient exercise, or idleness ; mental depression ; worry : improper cloth- ing; intemperance in the use of spirituous liquors and, especially, of tobacco ; incontinence ; any habitual excess ; want of good digestion and assimilation of food, leading to imperfect nutrition of the body; neglected or inactive skin, kidneys and bowels; a humid atmosphere from undrained, damp soil, or a damp house; the effects of certain diseases or dis- eased conditions, especially those affecting the air passages and lungs ; a neglected "cold on the lungs". ITS NATURE, CAUSKb AND rilEVENTlON. 143 UED. 3M iitious :ise to •ear to of the .ted as dition. ant of want cess of ig, etc.; cise, or clotli- liqiiors abitual tion of body ; ;vels; a il, or a or dis- he air lungs"; exliaustive discharges ; rickets, diabetes and syphilis ; and, in brief, anything that depresses tlie bodily vigor ; or diminishes the breathing : or vice versa. Many of these causes need oidy be mentioned here, while it will be well to further explain others of them. In considering the subject of prevention, they will then, too, receive further consideration. IMPURE, PREBUEATHEl) AIR. Of all the secondary causes of consumption, as inti- mated on previous occasions, from its direct association with one of the two essential causes, a want of oxygen, from the breathing of impure, prebreathed, deoxygenated air, is the most common and important. That eminent physician. Sir James Clark, M.I)., F.R.S., etc., wrote as follows (Cyclop, of Pract. Med.): "A sensible writer on scrofulous diseases considers impure air as the only real cause of scrofula : other causes may assist, but this he considers essential to the pro- duction of the disease. ' Personal experience,' says Baudelocque [whom Sir James here (juotes] ' read- ing, reflection on a great nundjer of facts, and tlie analysis of many observations, have impressed me with the deep conviction that there exists one princi- I)al cause of scrofulous diseases, a cause which pre- dominates over all others, and without which, nerhaps, the disease would never, or, at least, ' . ;■ rarely develop itself. This cause consists in particular con- ditions of the atmosphere in which the individual I'esides. However ill-chosen or unsubstantial his foo«l may be, however nmch cleanliness may be neglected, 144 COXSUMITION : Vfl)! .'" wliatcv cr hv i\w. nature of his clotliiii^ and its adap- tion to tlio temperature, whatever the climate in whieli lie lives, the exercise he tak(»s, or th(^ duration of his sleep or wakincj^, if the house in which he dwells he placed in a situation to which the fresh air and the sun's rays have free and «lirect access, and ^he house itself he sufficiently airy, lijj^ht and well p ^ jrtione*! to the number of its inmates, scrofulous disease will never make its appearance. On the contrary, how- ever well chosen or nutritious the food, however minute the attention paid to cleanliness, with what- ever care the clothino; 1k» adapted to the tempeiature, or the duration of exercise, sleep and waking he rejjju- lated, if the houses are so placed that the sun's rays cannot reach thtjui, or the fresh air be renew^ed with- out difficulty ; if, in short, they are small, low, dark and badly aired, sci'ofulous disease will evitahly su})ervene (Memo, sur les Scrof., Rev. ^ Vol. [).' Though we are fully satisfied of the pow^erful influ- ence of impure air in the production of scrofula, we cainiot entirely coincide with M. Baudelocque. The disease not infre(|uently affects the inhabitants of ele- vated and dry countries, wdiere the atmosphere is pure and the people are occupied in grazing sheep and cattle, and are hence so much in the open air during the day that the confined atmosphere of their ill -ventilated hovels can scarcely be considered the chief cause of the scrofulous diseases by which they are so often afflicted. . . . But there can be no doubt that the habitual respiration of the air of ill- ventilated and gloomy alleys in large towns, as w^ell as that of many ITS NATIIIK, CArSKS AND IMIKVENTIOX. 145 iiiHiiut'actonos, workhouses aiul even schools, is a |)()\vcrt'ul means of auj^nientinj^ hereditary disposition to HcroFuhi, and even oi' inducinj^ it, de noiut!' It may )>e observed in res{)eet to tliis, that those persons (!n«^a((ed in the (piiet occupation of ^razin|^ sheep and cattK% alluded to by Sir James Clark, take little active lun^-expanding exercise, and the function of respiration is but imperfectly performed. This, toj^ether with their " ill-ventilated liovels," deprives their body of the necessary supply of oxygen, and the soil for the bacillus is eventually produced. They may breathe " a very pure air " during the day-time, yet so little of it as to produce an effect similar to that of breathitig the foul air. Baudelocque further says, that a prolonged stay in a foul atmosphere is not always necessary to give rise lo scrofula ; but that often a few hours each day is sufficient, as in sleeping ill a confined room in which the air is not frequently changed or renewetl. Doctor Squire, in his late work, reports the case of a y(nuig man, seventeen years of age, in his (Doctor Squire's) hospital ward (N. Lon- don, for consumptives), who though belonging to a consumptive family, was himself " well-grown, and always strong and healthy up to the age of sixteen. He then went into service as a footman in Edinburgh, and shared with another servant a small attic bed- room, with no fire-place and only a small window which was rarely opened. After a few months in this place he developed consumption." The following, (juoting my own words (Phys. and Hygiene for Schools), is well accredited : Large numbers of the 10 l: 146 CONSUMPTION ii pupils at a school in Norwood, England, some years ago fell victims to consumption, and on investigation it was decided that insufficient ventilation and tlie consequent atmospheric impunity was the cause. Many years ago, consumption was very prevalent among the British soldiers. A sanitary commission, consisting of men of the highest standing, after investigation, declared that this \\'as caused by over- crowding and deficient ventilation : — in other words, by rebreathing breathed air. When this cause was removed, — more space in barracks and better ventila- tion provided — the number of cases of this disease inaterially diminished. Amongst well-to-do pei"sons as well as the poor wlio often cainiot well help it, there is nmch household overcrowding and consetjuent habitual breathing of foul air. In bedrooms especially, on every hand, in high-class houses, we daily witness the effects of breathing over and over again the same air. The rooms are made as air-tight as possible, and no means are provided for a change of air. Morning languor and want of vigor in persons, young and old, who otherwise would be healthy and strong, are as con)- mon as the morning awaking, and foul blood and scrofula are soon or later the individual consequences. Domesticated animals crowded together in stables, and wild animals confined in cages, we may again note, usually die of consumption. And again, the more dense the population, the higher the death-rate from this disease. Many other facts are upon record which prove that IliB ITS NATURE, CAUSES AND PREVENTION. 147 the breathing of prebreathed air is a most important factor in developing a condition favorable to con- sumption. And it is easy to comprehend this when we consider the highly poisonous nature of, and the lack of oxygan in, air which has been once breathed. Air polluted by various other impurities — dust, foul gfises, "malaria" and dampness, when breathed, is well known to produce depressing and other marked injurious effects upon the human body ; and by most pei-sons is shunned much more than prebreathed air. Pi Mi_i WANT OF SUNLIGHT A CAUSE. Absence of sunlight is usually associated with impure air. Air almost anywhere deprived of sun- light for even a few days becomes impure. It is fairly well known that there cannot be good health without abundance of full sunlight, yet many persons cut it off largely from their dwellings and rooms. The marked difference between' plants growing in shaded places and those freely exposed to the sun, and the paleness and frequent deformities amongst persons who dwell in dark alleys, " basements " and mines are w^ell known. A. N. Bell, A.M., M.D., records the following (Climat. and Min. Waters of U.S. New York : Wm. Wood & Co.) : Two kittens, one weighing 18 oz. and the other 18i oz. were selected. The lighter one wtis placed in a well-lighted box and the lieavier one in a like box but darkened. Both were fed and cared for alike in every other respect. In five daj'^s the lighter kitten weighed 22^ oz, and the other kitten only 20f oz. At the end of the second 148 CONSUMPTION five days, the former weighed 24 oz. and the latter Hcarcely 22. Both were then placed in the lighted box and in five days more each weighed almost 25 oz. It has been observed that there is more sickness on the more shady side of streets, and that patients pro- gress better in the more sunny rooms of hospitals. Besides its invigorating and purifying effects upon the entire body, sunlight is directly destructive of tubercle bacilli, as already stated : largely, probably, by its great desiccating power. It hf? ' sen suggested as " an all-sufficient germicide." A wa,.it of sunlight is therefore at once both favorable to the predisposition, and to the preservation of the seed. ■ i! THE NEGLECTED " COLD : WEATHER AND CLIMATE. A neglected or long-continued " cold on the lungs " is commonly regarded as, and is, a frequent harbinger of — an actual provider of a lodging for, consumption. It gives rise to a congested or an inflamed condition of the air chamber walls (the alveolar catarrh or alveolitis of Powell), and thus interferes much with the respiratory function ; while doubtless it often, at the same time, causes a break or abrasion in the pro- tective membranous wall, and so opens a way for the tubercle bacillus to get into the deeper structure, where, if there are favorable conditions for it, it may take root and propagate. It should be noted here, however, and remembered, that while the so-called " cold " is in this case the less remote cause of a predisposition, we may profitably |i;i(: ITS XATURE, OAT'SES AND PREVEXTIOX. 149 look back and ask, what is the cause of the cold ? Not, usually, in the main, is it anything beyond our control — not so much the weather, nor the climate, but far more the controllable habits and conditions of life ; probably breathing an overbreathed atmosphere, often in an overheated room, with improper clothing, inattention to the protective outer wall — the skin, and perhaps overeating. In many cases I have been able to induce patients, simply by means of a habit of daily cool bathing adapted to the constitution of the individual, a cooler atmosphere in living rooms, and proper clothing and food, to entirely overcome, in a few ^months' oime, the tendency to " take cold"; a subject that will be further discussed. Climate and weather, which give rise to conditions beyond man's control, are often blamed for causing colds and consumption when, as just intimated, the actual cause is, practically, more associated with man's self-governable habits. The powers of adaptation and accommodation possessed by mankind in general are .such that, if we except marshy and malarial and (lamp or misty districts, hardly any condition of climate is incompatible with good health, after accli- matization, in the average, or at least with a large proportion, of the race. One's natural climate, the one in which one is born, if not of a particularly objectionable sort, is usually best adapted for liealth ; l»ut one can usuall}^ with the practical application of hygienic knowledge, soon become acclimated to any country. There is not satisfactory evidence that W 1 1 150 CONSUMFTION there is any considerable number of people, any lar^e community, in any climate, entirely free from con- sumption. And, as stated by Douglas Powell in his late work already (juoted from, consumption " is essentially a scourge to what we call civilization. Its rarity amongst nomadic tribes and savage populations in all climates ; its prevalence in littoral districts, in river sites, and in industrial as compared with agri- cultural localities in townships and cities — all point to social rather than climatic influences as predom- inant in the cultivation of the disease." Nor can any climate be regarded as causing consumption. To be sure, in some localities, as those dry and sunny, the pre- disposition can be more readily overcome or prevented than in others. i THE SOIL AND DWELLING-HOUSE. Dampness of Soil is a subject which may be more practically and profitably considered, inasmucli as the dampness may be often remedied or removed by drainage and cultivation. Many years ago, at about the same time, the late Doctor (Sir George) Buchanan, in Great Britain, and Doctor Bowditch, in Massachu- setts, proved by statistical facts that consumption is more prevalent amongst a population living on heavy, impermeable, and hence damp soils, as in low -lying or high, undrained areas, than on a lighter, more porous soil susceptible to natural drainage. ' There is evidence indicating that a barren, sandy soil is inimi- cal to the life of the tubercle bacillus. Middleton has shown that the more impure condHion of the damp ITS NATURE, CAUSES AND PREVENTION. 151 air, usually, is a causative factor. Atmospheric moisture, when not too cold, doubtless favors bacterial growth and probably the preservation of virulency in the tubercle bacillus ; while usually bronchial dis- turbances are more common in the damper, colder localities, especially in persons not well acclimated or not vigorous. In this way the relationship between damp soils and consumption may be largely explained. Moreover, the skin is less active, and probably the respiratory function is less complete, as in respect to the exhalation of poisonous moisture from the lungs, for example, in a damp atmosphere. The diminished prevalence of the disease after drainage of the soil has been also conclusively shown. The Dwelling-house as practically an important factor in the development of consumption is worthy of notice. In both locality and construction it may become a remote predisposing cause ; and infected, too, and so favor the spread of the disease. Doctor Thorne Thorne (St. Barthol. Hosp. Rep.) sums up the " conditions of the dwelling-house tending to the promotion of tubercular consumption," as follows : 1. A soil either (a) naturally damp and cold ; or (/>) subject to the influence of the rise and fall of a subsoil water lying within a few feet of the surface. 2. A dwelling-house of which either the foundations, the area they enclose, or the walls are, by reason of faulty construction or otherwise, liable to dampness. 3. Such immediate surroundings of the dwelling- house as tend to prevent the free movement of air about it and its ample exposure to the influence of 162 CONSUMPTT'.)N V . ^ 1 II sunlight. 4. Such structural defects as would pre- vent the maintenance within all parts of the dwellinjr- house of ample movement of air by day and by night, and free exposure of its habitual rooms to daylight." Besides the depressing influence of living under cir- cumstances favoring dampness,, lack of ventilation and want of exposure to air and sun, such residence is followed. Doctor Thorne adds, bj^ " bodily lassitude, which in turn often brings about loss of functional activity in cer^.ain portions of the lungs — a state whicli is most grave when battle has to be done with an extraneous living organism, seeking to obtain and maintain a habitat th ein." The dust in dwelling- houses, as well as in shops, offices, etc., is often a source of lung irritation. Dust is made up of particles of almost all sorts of substances, organic and inorganic, and is inconceivably complex in its composition : — of particles from insec^w and domestic animals, as well as from the human body, and may, and indeed not infrecjuently does, contain infections. Much care should be exercised in keeping dwellings as free from dust as possible. Furtaer on, evidence will be given showing that houses may become infected, and then retain the infection and communicate it to other per- sons. The following case (Brit. Med. Jour., April 8th, '93) may be given here as particularly instructive: " A family of nine persons moved into a house in Paris inhabited ten years before by two consump- tives. A short time after, although the whole fam- ily had always previously been in excellent health, three among them showed symptoms of tuberculosis. ITS NATURE, CAinsES AND PREVENTION. 153 They used the same bedroom as the former consump- tives. Doctor Ducor had pieces of the wall paper and dust from the ceiling and walls examined, and in both tubercle bacilli were found." Workshops, factories, and other enwalled places, as well as dwellings, may obviously, in like manner, become causative factors of this disease. ' THE DIETARY: COOKERY. An improper diet has always held >'' high place in the list of predisposing causes of consumption. In respect to it, here, and to bad cookery, I prefer to again quote Sir James Clark, and also Sir B. W. Richardson. Among the causes of consumption, Sir James Clark writes, an " Imper act supply of food holds a conspicuous place. But we have rarely an opportunity of seeing the effects of this alone," he adds, " because when the means 'of procuring proper nourishment are wanting, there are generally other causes of the disease in actioh at the same time ; such as residence in ill-ventilated and dark apartments, exposure to cold from imperfect clothing, etc., the whole of which are often coAibined, and hence more speedily effect the deteriorat'on of the health. Food in excess, or of a kind too exciting for the digestive organs, may also induce tubercular cachexia, a cir- cumstance which is not sufficiently attended to — we may say not generally understood — even by medical men ; neverthtless, we hold this to be a frequent cause of scrofula, and believe that it produces the same effects on the system as a deficient supply ; the I 154 CONSUMrnON .(■■■•r ■"^^ imperfect digestion and assimilation in the one case and the inadequate nourishment in the other being equally injiiriouH ; the form and general characterH which the disease assumes may differ, but the ulti- mate result will be the same in both cases. The adaptation of food, both in quality and quantity, to the age of the individual, as well as to the powers of the digestive organs, is too little considered ; and the evil consetjuences of this neglect are often evident in the children of the wealthy classes of society, who are frecjuently allowed an unrestricted use of the most exciting kinds of animal food." Bad dietary and bad cookery. Sir B. W. Richardson remarks (Preventive Med.), " are active causes of dis- ease in, perhaps, all classes of the community, but especially amongst the poorer class. ... In cases where the food is fairly good in (juality as it first comes to hand, it is so destroyed by the various pro- cesses of cooking and preparation that half the pro- portions of it, as digestible, wholesome and sustain- ing nourishment, are sacrificed. . . . The digestive system is first injuriously influenced by errors in dietary ; Imt many other of the vital systsms, includ- ing specially the circulatory, the nervous, the glandu- lar, the muscular and the membranous, are injured by these errors in respect to the supply of food for the sustenance of the body." Hence, in such circumstances the body is often not suflliciently nourished, and general debility follows, with, most likely, lassitude and imperfect breathing. ^li iiiitiiii' ITS NATURE, CAUSES AND PREVENTION. 155 OCCUPATION, TOHACCO, ETC. Certain dusty and otlier occupations favor a pre- disposition to consumption. Those which tend in any way or degree to interfere with a full respiratory function, — such as give rise to more than the usual amount of dust in the atmosphere breathed, or in which certain body positions, more or less necessary, cramp the chest or limit the full and free expansion of the lungs, are especially so. Dust is more lung irrita- ting than it is connnonly supposed to be. In a large number of manufacturing industries, as of pottery, cutlery, flour, woollen goods and many others, the dust produces an irritating effect upon the delicate lung membrane, which, when continued, interferes greatly with the respiratory function. Those occupations, too, in which it is necessary to work where there is not abundance of sunlight, as in dark rooms and mines ; and in which the temperature of the air is kept too high, or above about 60*^ or 65® F.; also, except in the most vigorous constitutioned persons, such as cause exposure to inclement weather, or to sudden changes in it, to irregular habits, broken sleep, confinement in- doors, etc., favor the predisposition ; and, therefore, should be avoided by all who are not of full vigorous constitution. The use of tobacco, as a remote cause of consump- tion, is deserving of special notice before concluding this part of the subject. It is in no way or degree an essential of life or health to anyone, nor is it ever contended that it is, but, on the contrary, is an un- ! i i 156 CONSUMPTION : natural, accjiiired liabit, adopted, it appears, in imita- tion of an uncivilized people. Whatever may be th»' soothing effects or germicidal properties of this most powerfully noxious, depressing weed, and however many persons may live to advanced age in spite of its long use, it cannot fail, however moderately used, to depress, in a proportionate measure, the vit^l functions and powers. Then, in support of such a natural theoretical conclusion, we have the recent experiments of Professor Harley in testing the influence of tobacco smoking on muscular work, and his declaration, based thereon, that it " highly diminishes muscular power and hastens the onset of fatigue." Since the above (of this paragraph) was written, strong evidence of the irritating eftects of tobacco in causing tubercle of the tonsils has been published (M. Tussau, Lyon Med.). Of the other remote causes of this disease, above enumerated, it is not difficult for anyone to under- stand that they indirectly depress, in a certain measure, the vital powers of the body and so debilitate the system ; it may be in a measure entirely inappreci- able for a time, or unknown to, or unrecognized by, the individual, yet still they debilitate and depress. Amongst the poor, for example, in their struggles for existence, and sometimes amongst the well-to-do in their struggles for wealth, excessive labor prostrates the vital powers. So, with idleness or inactivity, like effects are produced, like results follow. TVere is then with such depression, besides other functional defects, almost always a tendency to stoop, with con- sequent lung compression and diminished respiration. CHAPTEE VIII. CAUSES OF CONSUMPTION CONTINUED. THE INFECTIOUSNESS AND COMMUNI- CABILITY OF THE DISEASE. ■■^ GENERAL REMARKS ON INFECTION. Some physicians of the highest standing and much experience still question the infectiousness or "con- tagiousness of consumption. It would appear as if this, in a measure, may arise from the very indefinite, unsettled general application to diseases of these two terms, infection and contagion. What an infectious disease is, precisely, or where the dividing or distinguishing line is between one that is infectious and one that is not, has never been, in practice, clearly or satisfactorily explained. Still more unsatisfactory has been the use of the term con- tagion. The two terms, too, are commonly used almost or quite synonymously ; while their practical application varies somewhat in different countries. It would be well if some authoritative organization would fix upon a form of application of them which could be brought into general use in medicine. The wide difference between the derivation of the words — one, infection, from a word signifying, in the orig- inal, to dye, stain or corrupt ; and the other, to touch r^- 158 CONSUMJTION ! I k 11 ['ii **'' i 1^1 "' Hiii^£ (contaction, toucliinf^) — together with the facts that some H()-calIe«l iufcctiouH diseasoH are of a much more infectious nature than otliers — more liable to be com- municated from the sick to the healthy — and that some diseases regarded as both infectious and contagious may arise by means other than direct conuimnication from infected to non-infected persons, make tlie sub- ject a complex one. The term connnunicable has therefore come into more gen(;i'al use in this connec- tion during recent years. Without entering into a lengthy discussion of the general subject of infection, a few remarks here on some points of it may be of practical use. All infectious diseases have as an associated and essential factor a specific germ, in each disease of a kind peculiar to itself. Almost all of them, too, possi- bly the so-called malarial diseases, are connnunicable from a person aftected to one not affected ; they are " taking," and by means of the specific germs, in one way or another. Some, as hydrophobia and scabies, are taken only by actual contact ; others, on near approach to them — atmospheric ; and yet others, apparently only by means of some solid vehicle, as food, clothing, etc., or of water. As to the infectiousness, contagiousness and coin- municability of small-pox, scarlet fever and measles, for example, there is no question. Nearly everybody not protected by a previous attack, on cl< se eA£*usure to these diseases, becomes infected kcs then? The exact nature of their respective > eific infec. ms or germs is not yet known ; but it il|»|»eal•-^ evident that ITS NATURE, CAUSES AND PKEVENTlON. 159 ll"' the geririH are given off, and very abundantly, from tlie surface of the body througli the skin, vvhiK' tlioy are probably much more minute than tliose of tlie less iiifectiouH di.seaseH, and so tlie easier get within the body. If we eouM see them, wt; should perhaps observe myriads of tlu^m in the air around about and near to a case of either disease — somewhat, perhaps, as we see the myriads of spore-carrying particles fly off from the puff-ball fungus when it is touched, with which everybody is familiar. Then these germs, like many ill weeds, take root and* grow in almost any soil : almost everybody provides, at one time or another, a suitable soil. These are clear, well-known types of infectious, or contagious, connnunicable diseases. On the other hand, good authorities long questioned, and it appears that a few still (juestion, the infectious- ness or communicability of typhoid (or enteric) fever. Especially is this the case in regard to its communica- bility by means of the medium of air, as distinct from that of water or milk. It is with this disease as it is with consumption : comparatively few persons who are simply exposed to it, take it in the ordinary vvay, or as in the case of scarlet fever, etc. Both diseases hold a place intermediate between the more characteristic infectious diseases and malarial diseases. In both, the germs are contained, for the most part if not entirely, in the excreta from the bowels and lungs, respectively : and although given off abundantly in this way, pro- bably not in numbers nearly approximating the numbers given off from the skin in the other diseases above named, — just as some plants in ordinary vege ta- il i8 160 coNsuMrrioN ^k-i n Mi 1!5 tioii yi»»M niany more himmIh tluin do v/ther ])lHntH. 'V\\i',y aiv, too, in a condition in wliicli thoy cannot nearly so rcatiily fly alumt in thc^ atnioHphcrc around tlu» ptTHons inl'(H5t(Ml. A^ain, tliey are apparently more tejuler schmIh and will oidy ^rovv in .sp 'ial soils — " rich" soils, it may he supposed, as already intimated: as a rule, prohahly only in I'oul conditions of tlie intestines and lun^s, res|)ectively. As stated on a pr»»vious pa^e, too, it may he here noted, some hijjjli authorities helieve, and on ^ood evidence, that typhoid Fever does not always arise l)y infection, as we coni- moidy understand this term, hut that it sometinu^s arises anew, de novo, from f;jcrms which had lost their virulency hy exposure to air, li^ht, etc., and which are made ajjfain virulent hy insanitiiry con- ditions; or, as some helieve, from the transformation of the heni^n hacillus coli comnumis into the virulent hacillus typhosus. Similar, it appears to be, with consumptio!!. Attain, in respect to diphtheria : we have already v>Kserved Trouessart's belief, that a child contracting^ a simple (indamed) sore throat, the pro- duct, or discharge, from which excites into virulent action diphtheritic micrcK'occi, which up to this time had remained inert in the mouth, and a form of diphtheria is proiluced (tbe micix)cocoi being possibly the early fonn, and the bacilli the adult form, of one species of micro-organism). Physicians generally, it appears, believe that this disease may not infrequently arise in this way, or by means of inert or dormant germs from some source other than a present case of the disease — practically de novo. Hence, they habitu- ally recommend parents to exercise watchfulness cind "W'^l'"? ITS NATURE, CAUSES AND IMIEVENTION. 161 lunts. iDiiot ound entiy )ilH — latcil: f the on a rphoid ! cuni- I'tinu'-s (I lost ;., and V con- niatiou irulent ), with a: we a child lie pro- iiruleiit s time )riu f 1' care in caseH of Hiinpl(3 Horcj thro.';t in tlujir children. We would not Hay that ca.se.s arisinj^ in this way had heen cauH(Ml l>y, or had ari.sen by nMians of, infection from another person. Some outV)r(;akH of typhus fever can only be <;xplained in a sonniwhat similar manner. (Jood authorities look U])on intensity of population or overcrowdinj^ in a dwellinj^, or a collection of dwell- ings, as practically the excitinj^ cause of this disease. The CKsential j^erm or seed is always a factor in the causation or origin, and j)revious to the outbreak it had been jj^rowin^ or lui'kinjjf sonn.'where in a non- virulent state until <'xcited oi* intoxicated into patho- jjenic action by the foul products of the overcrowding. (Jonsumptiim, too, as already noted, we must bear in mind, is analo<(ous to typhus in this respect, and becomes the UKjre prevalent in jjroportion to increase or density of population in a ^iven or limited space, even to tenfold, it is recorded ; as, for example, in a city's slunjs. Regarding the infectiousness of consuniption, D(x;tor H. Douglas Puweil, who does not believe the disease is infectious " in the ordinary circumstances of life," wri*:es as follows (^tiol. of Phth.: J)is. of the Lungs): " We can practically say, with many of the zymotic diseases, e.(f., enteric fever, cholera, scarlet fever, that we have health on the one hand and a specific organism on the other, and that thi^: latter invades and destroys Hie first. We can rarely, 'fever, say this of tubercle." Now, it is (piite possible that this apparently wide difference between " tubercle "- consumption, and the oilier diseases named by Doctor Powell is in a large U I 162 CONSUMl^TION i'i hi 'I ii |:f iTiil measure in the degree — the pert'eetness or otherwise, of what he terms the " liealth " of the exposed person. According to Doctor Alfred Carpenter, as we liave already observed, a person in perfect health — that is, with all the various organs in full harmonious action, and hence the body fluids and tissues free from any excess of used-up, eflfete or excrete waste matter — will not take, or will not manifest symptoms of, any infec- tious disease — will not harbor the infection long enough. Such person provides no soil for what Doctor Carpenter evidently regards as saprophytic micro- organisms. It is possible to imagine, perhaps hardly to attain, such a degree of personal health as would resist all disease germs. A short step was made, how- ever, in this direction a century or two ago (even thousands of years ago, it appears, by Eastern peoples) when direct inoculation with small-pox virus was practised on persons previously prepared for it by a course of hygienic treatment. As already intimated, with a sufficiently complete system and course of hygienic preparation of the individual to be inoculated, possibly the small-pox infection, instead of being only modified or simplified in its action after such inocula- tion, might, if not from highly virulent sources, entirely fail to grow in the purified body from want of natural imtriment, or be resisted altogether by the natural forces of the thus prepared individual. So it is pos- sible that it is only apparent and not absolute healtli " on the one hand," as Doctor Powell words it, " which the organism invades and destroys." In other words, a much greater falling-otf from the health standard of ll;,..:',^H I ITS NATURE, CAUSES AND PREVENTION. 163 Wise, rHon. liavo at is, ction, [I any —will infec- lonK )octor nicro- liarcUy would », how- (even fcoples) as was it by a Linate<l, rse of ulated, ig only Inocula- ntirely natural Inatural is pos- health ' which words, dard of the individual host seems to be necessary for the action of th(5 tub- rcle bacillus than for the infectious germs of otlier diseases. There are probably very few persons so healthy and vi'vorous as not to succumb to the effects of inhal- ing enormous numbers of active virulent tubercle bacilli ; as in certain experiments by Tapi)ioner with dogs in a room the air of which was charged with the bacilli ; to be noticed further on. The germs would reach the lungs in such numbers that possibly the phagocyte cells and blood-serum antidote could not successfully resist them (Orth), Or, what may be still more likely, germs may sometimes — in certain conditions and circumstances of environment, as in certain foul-conditioned human bodies, in a highly " scrofulous " person iv the case of tubercle bacilli — l)ecome so virulent, so irritating, so poisonous, that, when at once conveyed into the body of another and fairly healthy person, oa any person, they quickly poii in and destroy tlie life of such an amount of invaded tissue elements or substance as to provide themselves — their phagocytic, perhaps now patho- genic, appetite — with dead matter, and so possibly, if not most vigorously opposed, be enabled to go on with their destructive w( V. It can only be said, then, that the infectiousness of a disease, or the degree of it, or the frec^uency of its communicability to others, is largely a question of (t) the number of active specific germs given off from the body of the infected person, (6) the degree of virulency, or of poisonous character, of these germs , I IHi! i'iiiiii i! liiWiaii- m 164 CONSUMPTION : — as from their source, — ami (c) the body coiKlitioii, or soil, presented f )r tlie root-takiiif^ or growth of tlic germs by the non-iafected exposed persons. HISTOIIY OF THE INFECTION THEORY. From the period of the earliest records in tlie liistory of medicine, it appears tliat tlie infectious nature of consumption — the possibility of it being canununicated from the consumptive to others — has been believed in by physicians of the highest repute. Over two thousand years ago (400 B.C.), in the time of Father Hippocrates, physicians believed in it. Aristotle (330 B.C.) wrote that the Greeks in his day believed in it : and he asks why eonsumpticm, sore eyes and itch are conunon to persons who asso- ciate with others suffering from these aliections. Later (A.I). 180), Galen wrote that it is dangerous to pass the whole day with a consu^nptive person. Coming down to much more recent periods, Morton, over two hundred years ago, wrote of consumption that •' a contagious principle often propagates this disease, for, as I have often found by experience, an affected person may poison a bed-fellow by a kind of miasma like that of a malignant fever." Riverius, about the same time, believed contagion to be the " chiefest " cause of consumption. " We may observe women to be affected by their husbands," he wrote, *' and men by their wives, and all the children to die of 'he same, not only from infection of their parents' setd, but from the company of liim that was first infected." The eminent Italian, Valsalva, in the early part of ITS NATUilE, OAUSES AND PUKVENTIOX. 165 hist century, was hiiiiself prodisposed to consumption, and avoided bein^ present at dissections ol' the hnigs of persons who liad died of the disease. V^ilsalva's illustrious pupil, Morgagni, declared that he made hut few post-mortem examinations of pei'sons who had died of this disease for f(»ar of contracting it. A law once existed in Italy by which the proprietor of a house in which a consumptive had died could claim payment for his furniture, which was burnt ; and it was difficult for a consumptive to obtain lod<(ings. Over a century ago, a reaction connnenced to show itself. Eventually, in northern Euro})e and America especially, doubt respecting the infection theory developed into general disbelief. In the warmer lati- tudes, however, this was not the case, and at length there was a change again in the more northern coun- tries; and with the results of the investigations of the last few decades, disbelief and doubt have for the most part disappeared. In 1805, Villemin inserted mirmte particles of tubercular matter from man and from the cow under the skin of rabbits, and after about fifteen days found tubercles in the lungs and other parts of these animals. In 1807, Doctor Wm. Budd (Lancet, Oct. 12,) took strong ground in favor of the infection theory. He concluded that tuber- culosis is a true zymotic disease of speciHc nature, in the same sense as typhoid, typhus, and scarlet fevers. The evidences of this he finds in, — (n) Considerations based on the pathology, consisting in the evolution and multiplication in the organism of a specitic, mor- bid matter. (/>) Actual instances in which there is Ififi COl^srMI'TloN : It f ' : i evideneo to show eoininiinieiitiotj from one to another ((') Tlie ^eognipliical distrilnition of phthisiH, and eHpecially its fatality in coinitries vvliich were entirely free from it wlien first discovered by Europeans. {d) Its f^reater prevalence in low levels and crowded communititis, and entire absence, except by importa- tion, at hi^h levels, (c) Its hi^h rate of prevalence in convents, barracks, penitentiaries, etc. IIISTOUICAL EVIDENCE OF INFECTION. Wlien the South Sea Islands were first discovered, Doctor Budd says, there v^as no consumption amongst tiiem : but since they h -ve come in contact with Europeans, the disease has . ecome so wide-spread as to threaten their extermination. The late Doctor Rush, of Philadelphia, who made accurate inquiries, satisfied himself that there was no consumption amongst tlie American Indians when America was discovered. Now it is very common and fatal amongst them. In Africa, everywhere along the seaboard, says Doctor Clapp, where the blacks have come into intimate rela- tions with the whites, there has been a large mortality from the disease, but in the interior, where there has been contact with only a few travellers, it has not been ftmnd. Of this fact. Doctor Livingstone and other African travellers, it is said, have given Doctor Budd positive assurance. It must be remembered, however, that certain obvious habits of civilized life, introduced amongst the natives of these countries, have doubtless contributed largely to the development and spread of the disease Vi . ■■ ITS^NATURE, CAUSKS AND IMIEVENTIOX. 107 ti,si<le from tlits infoctioUH ^erinH, and licnce cauHed it to appear more actively infectious than it really is. In a pamphlet (Con taf(. of Phthis., 1888) by Law- rence F. Flick, M.D., of Philadelphia, Pa., the author Hays, •' Those portions of our country which were s«'ttled by the Spaniards, namely, California, Arizona, New Mexico, Texas, Florida and Colorado, were almost absolutely free from consumption until they became the Sanataria of consumptives from the north and north-east. Intelligent natives of these countries will toll you that, prior to the mingling of the English-speaking people amongst them, the disease did not occur in their country. In fact, it was the gerierally acknowledged freedom of these places from the disease that gave them their reputation as resorts for the phthisical. . . . The whole Pacific coast, as well as Florida and Colorado, is accjuiring a doubt- * ful reputation for consumption. A look at the map of the United States Census Report for 1880, in which the topography of phthisis throughout the United States is indicated, will be apt to shake the confidence of the searcher after a climate for the cure of consumption, so far as these countries are con- cerned, at least. The islands of Bermuda and Madeira probably underwent the same experience. Both, at one time, enjoyed the reputation of being ideal climates for consumptives. They have both lost that reputation because the disease became too prevalent there. The history of Madeira is especially interest- ing. The natives of that island so feared consump- tion that ' no pecuniary consideration *rhatever would I 168 CONSUMPTION : .'! /»X tsff >M m induce them to aceoiiunodiite plitlnHical patients, wrote Doctor Jolm Gordon, in J 784. And well thev might fear it, for, after yearg of introduction by the English, the disease became endemic in the island. Doctor William (iourlay wrote, in 1811, 'that the disease of phthisis pulmonalis was an en<lemic in the island, and that its fatality was prodigious among the inhabitants.' There is reason to believe that the Jewish people were free from the disease whilst they dwelt in the Promised Land. The disease is referred to in the Old Testament as a disease of Egypt, and is spoken of as a visitation or plague." STATISTICAL EVIDENCE OF INFECTION. In Germany the sick in the hospitals are largely attended by members of religious sisterhoods, and these sisters are conseijuently much exposed to the infection of consumption. "Taking thirty-eight of these nursing corporations. Cornet found that, during the last twenty-tive years, of their total mortality, 62.8 per cent., or almost two-thirds, was recorded as being from tuberculosis ; while of those members of the corporations dying between the ages of twenty- tive and thirty-tive, no less than 73 per cent, had succumbed to this disease." In his translation of Ziemssen's work on Tubercu- losis, already quoted from, Doctor Doherty gives, in an Appendix, reports for the years 1887-88, from thirteen prisons in the United States in which the average mortality from consumption had been over 50 per cent, of the total mortality ; more than half ITS NATURE, CAUSES AND IMtEVENTION. 169 the deaths of the prisoners heiii<»; from this disease. In the Clinton Prison, N.Y., the mortality was ()6 per cent.: in that of Joliette, III, and the Eastern, of Pennsylvania, over 77 per cent. Evidence of the infectiousness of consumption was broujrht out a few yeai's a^o by Doctor Flick, above cited. He localized all the deaths occurring from the disease in one of the wards of that city for a preced- ing period of twenty-tive years,and showed that nearly one-third of the houses in that ward had been infected by previous cases of the disease. In many of these houses the deaths from it had been numerous, and of the total number of them in the ward during the year 1888, more than one-half occurred in the infected houses although there were more than twice as many non-infected as infected houses in the war<l, Tlie infected houses, it should be noted, were, doubtless, in other insanitary conditions, probably damj) and not well lighted. In 1883, a committee was appointed by the British Medical Association to make collective investigations respecting the infectiousness of consumption. The committee sent out circulars to members of the pro- fession in England asking for reports of facts bearing upon the subject. Over one thousand answers were received, in about three-fourths of which the evidence was negative, while about one-fourth related to special cases in which the disease was believed to have been communicated by infection, the majority of them between husband an- wife. 4, 170 CONSUMPTION : HISTORV OF INDIVIDUAL INSTANCES AND CASES, Instances of tlie importation of consumption into villages in France previously free from it have been collected by Doctor Allison (Arch, de Med., Sept., 1885). Respecting these I take the liberty to quote Doctor Squire's remarks : " Individual members of healthy families, living in villages where consump- tion is quite unknown at the time under observation, visit other localities and stay with phthisical persons. They become themselves consumptive, and on their return home other persons in the village, who are on terms of intimacy, or who live quite close to them, also become affected. In other cases a phthisical patient from elsewhere comes to live with healthy persons in a village previously free from phthisis, and those with whom he lives become consumptive. Allison concluded from his observations that phthisis, intr Juced into previously healthy districts by an affected person, spreads to those in close contact with the individual, and having attacked the susceptible, disappears in that locality until reimported." The following case, from this series of observations, is given by Doctor Squire as an example : " A man aged forty-five years, living in a village in which no deaths from phthisis had occurred during the pre- vious ten years, was accustomed every year to visit, for a week, his brother-in-law who lived at another village 150 kilometers from his own home, and who had consumption (pulmonary tuberculosis). In 1880, the subject of this observation had pleurisy, and on iiii ITS NATURE, TAUSES AND PIIEVEXTJON. 171 IiIh return IVoiii liis viHit next year to his brother-in- law, \vit!i whom he sh'pt, he hiniHelf l)eeaiiie aHected with plitliisis, and died in 1884. He infected two other persons in his native viUaj^c " who lived near him (Hyjr. Prev. of Consump, Lond.: C. (Iriffin & Co.). An instanc(^ was reported a few years aj^o (Brit. Med. Jour.) of an apparently infected office in Paris in which thirteen of the clerks had died of consumption in four years. Infection was attributed to the prac- tice which prevailed in the office of spitting on the floor. A most remarkable instance of house infection is j^iven by Engelmatni, who relates the history of a dwelling which for eight years after its erection remained free from tuberculosis. Then two of the inmates died of that disease after some months' illness. From that time onward for the period of twelve years the dwelling was inhabited by a number of diti'erent families in succession, and was scarcely at any time free from consumptive patients. Thirteen fatal cases occurred in the twelve years. A startling account of an epidemic of tuberculosis was given at the Paris Congress of 1890. Of thirty-five workmen in a certain factory, twenty-seven suffered from tubercu- losis ; four had the disease previous to admission, and twenty-three became affected in the factory. The period of incubation was two months (Prof. J. E. Graham, M.D., add. Can. Med. Assoc, meet., '92). Many individual instances of cases ai"e upon record in which it appears altogether probable, indeed seems hardly open to doubt, that the diseasf -/as communi- cated by infection. Want of space prevents the 1 ru ^H L -ft 1 pi' m 1^^^ ^ 172 (JONSUMITloX : IS. ■I mw (l(3tailH of iiwmy of those bcin^ j^iven herein, but tlic brief history of a few cjises, as an example, will be instructive. The following synopsis is from a notable collection of similar cases by Herbert C. Clapp, A.M., M.D., of Boston (Is ('onsump. Conta<?. ^ Boston : Otis Clapp & Son, 1881): "Twenty-five cases" aw described which, as the author says, " make mention of sixty-six persons who became consumptive prob- ably through contagion." They were collected from different authorities, the names of which are given in Doctor Clapp's book. At Haynin, in Belgium, a woman died of tubercular consumption of the third stage, having slept with her husband to the last. The latter, of an originally sound constitution, and belonging to a family in which consumption had never been known, took for a second wife a woman of an equally strong constitu- tion and of healthy parents. After eighteen months of wedlock he yielded to pulmonary consumption. The second wife continued to sleep with him until his death. A short time after this she married again, and two years after the second marriage, died of con- sumption. Her second husband, perfectly robust, and belonging to a family which had never known an instance of consumption in it, yielded to this affection sometime after the death of his wife. J. had seen his mother, two brothers and a sister die of pulmonary consumption, and had himself, on two occasions, haemorrhages from the lungs when twenty and twenty-one years old. He became a sailor, married at the age of twenty-seven, and had ni a fec'tb until anil thir( ance and The i!iiaiifei ITS NATUHE, CAUSES AM) IMlEVENTloN. 173 in all four wives : Fii-st, a woman Iwlonginjj to a per- fectly healthy family, who enjoyed excellent health until her third pregnancy, when .she bej^an to couj^h and grow thin. She died of consumption after her third continement. The second wife had every apjiear- ance of health, but at the end of a yc&v began to cough and spit blood, and soon died of "(piick consumption." The third wife belonged to an exceptionally healthy family, consisting of a father, mother, four brothers and two sistei-s, all living and in good liealth. Seven weeks after her second confinement she showed extensive disease in the upper part of the lungs and (lied shortly after of tubercular consinnj)tioii. The fourth wife, twenty-three years old, had not a sign of consumption in her family, and was in the enjo^'ment of perfect health. Thirteen months later — three months after her first continement — she began to cough, and died nine months after. TUe autopsy showed tubercular lesions in both lungs, intestines, spleen and liver. The history of J. is instructive. At two different times — in 1854 and 1857 — during the illness of his fourth wife, Doctor Herman Webber, who reported the cases, had occasion to examine iiim. His general liealth he (J.) said was excellent. He did not cough, but expectorated in the mornings (upper part of left thorax flattened, and less resonant). He continued to do active duty cls a sailor until 18(59, when he was forced to keep his bed for some months on account of a severe fracture ; he then began to cough, consump- tion developed, and caused his death in 1871. M- 174 (;()N.suMrri()N : ■'*''. TO ii II t. • 'i, 1 M \\ il ' 'l§ '■ Mr. H., of a conHUinptiv(! liriouj^t;, inarricMl a. MIhk H., of a roniarka}>ly hoaltliy family, ijoUmI for loii- g(!vity. H. continuod to j^radually ^row vvorHC, an<j <li(Ml at tli<3 oxpiration of «;i^hteon iiioiithH. His wife; was his coMHtarit companion and nurHo, and Home three nionUiH hefon; his deatli the premonitary syni])- tojriH of pythi.siH inanifeHted tlieniHcdves m her, and some twelve montliH after his death she die<l. One c!hild was horn of the marriajre, which lived ahout one year, and died of tubercular meningitis. Mrs. H. was elo.sely nursed by a sin^^le sister, who, some time; prior to the d(;ath of Mrs. H. gave unmistakable evidence of commencitig tuberculosis, and diinl some twelve months after. The singh; sister was nui^sed by a younger brotlier, and he only survived liis last sist(!r's death a fiiw months, dying of the sauM! disease. The remainder of Mrs. H.'s family HvcmI at a distance, were seldom at her house during the sickness of any of those above recorded, and not one of them has over had any disease of this class. The fath(!r and mother were living an«l in good health, aged between eighty and ninety years. t^ws?.^-^- EXPEIU.MENTAL KVIDE.NCE OK INFECTION. TappeiiuT dried and pulverized expectorated matter from the lungs of consumptive persons and sprayed tlu^ powder in the atmosphere of a room in which dogs were contine<l. Dogs tire not very susceptibh; to tuberculosis, yet in this way they contracted the disease. Bertheau made like experiments with like results. It is stated that when Tappeiner was per- «m|PWH ITS NATURE, CAUSES AND I'UEVEXTION. 175 foi'iniii^ his (3xperiinentH, a robust servaDt, «f(ofl forty, lauf^ljod at tlio i(l(!a that couHUinption could be; corn- iinniicat(Ml in that way, arnl in Hpitc; of all warning \V(;nt into the inhalinj^ room, breathed the inf<;ction and died in fourteen w<;ekH of coriHuniption. (iiVioux put raV>bitH in a elo.se oa^e, and intnxluced into the cage air jxpired by (if,., the lireath of) coiiHUinptive persons. In thr(M; months the rabbits showed marked synijjtoms oi' tuberculosis, and tuber- cles were found iti many parts of the body — mostly tin; lungs. Another cage of rabbits he supplied with the same sort of an atmosphere, exce-pt that he first filtered the ))reath«^d air through tow charged with •arlx>lic acid. No signs of tuberculosis in these animals followed. The well-known spr(;a*l of tulx-rculosis amongst the lower animals — in heivls of cows and fl<M;ks of poultry — and the (!vid(;nc(! to be given in another chapter r(jHi)ecting the probable intercommunicar»ility of the disease Ix^twiMjii mankind and the lo\v«'r animals, afford a<lditional testimony of th<; inf«*(;tious nature of this disease. II A CFRf UMSTANCES MODIFVFXf; THE ABOVE EV/DENV'E. Then; are modifying circumstunc<'s bearing upon iimch of the above-mentioned evidence of infecti<jn in this disease; which it is desirabh; to notice and Ix'ar in mind; this e'jpecially as I'dating to tlu; <h'gi-e«; of infectivity or compai'ative fre(|uencv of spread in this way. For example, in referencj; to the inmates (»f convents : the bacillus could not infect, were not 176 C()NSUMI»TI()N i.1;i I II the body condition of tin utuiateH spocially favorabli'. As Zieinssen words it, " t ■>■ privation of fresh air and the complete lack of bodily exercises which compel deep ins])irati<>MS are the chief causes of the disease:" — they are in<l«'i d th»' more important, the exciting, and the more pr'\«ntable cau>»'H. There are, too, many other depressinj;, and hence causative, circum- stances in connection with the sedentary life of such persons, so obvious that they need not be mentioned, which help to swell the phthisis mortality amongst them. Air,ongfst pupils in the lar^e schools and the imnates of orphanagjes, the moi'tality is higher than the average of that of the general population, but not so high as that of persons in convents a.id prisons. Why ? Because, chieHv, the confinement in the for- mer cases is not so close, and the younger jieopio do not remain so long in such places, as in the laC"'- It is especially noteworthy, too, that the mortality amongst the inmates of convents and prisons is pro- portionately greatest, as would naturally be expected, in those who have been longest in confinement. Again, criminals, as a rule, both from constitutional structure and habits of life, are the more likely to have a predisposition to consumption. Persons nursing others sufi'ering from this disease, as a wife a husband, are exposed to other causes of it as well as to the infection : — the stooping, lung-confin- ing position often required, the confinement, want of rest and often of sleep. The close devotion, too, of a wife or a sister to the nursing of one near and dear, makes the position a much more trying and exposed one than in the case of an ordinary nurse. ITS NATUllE, CAUSES AXD PREVENTION. 177 Finally, re.spticting (iilx)ux's experiments: Had Giboux cauHed tlie rabbits to breathe only the already breathed air fjoni persons not consumptive, the result might have been the same. The toxic effects on the animals of the usual poisons in expired air might have caused the distuise in the rabbits, if in any other way tubercle bacilli, possibly dormant non-virulent ones, could have gained access into the lungs of the animals, rendered strongly predisposed — with tissues providing the exciting cause — from inhaling simply the foul prebreathed air. KVIDENCE OIMMJSED TO THE INFECTION THEORY. Positive evidence against the theory that consump- tion is sometimes connnunicated by infection is in the very nature of things difficui't or impossible to obtain. Kvidence against it nmst ever be, therefore, rather of ii neutral charactei". The evidences which is most commonly given in opposition to the theory is that of statistics of the Hrompton Hospital for Consumptives, in London. These extend over a period of more than a third of a century, and certainly give n ) evidence of infection. AiiKjng the twenty-nine resident physicians and assistant physicians of the institution during that period, there was but one case of consumption, and the siibject of it was tubercuhms before entering the hospital. Of one hundred and fifty clinical assistants, eight died of consumption, but only one of these eight was free from the disease at the commencement of the clinical duty. Of one hundred and one nurses, 13 JL ^ 1 1 1^ I . 4 ft " 1 t< ",i; .:i 1!1 178 CONSUMPTION only one was consumptive. The variously appointed servants were alike exempt from the disease. More recent statistics from the Friedrichshain Hospital, Berlin, give a like record. It is very well known that physicians and their assistants, and even nurses, but rarely take any infec- tious disease when attending cases of it, even scarlet fever and diphtheria. They are usually in such a body condition as not to provide a soil for the germs. Less frequently do they take typhoid fever and Asiatic cholera. A few well-auchenticated cases in which, for example, a healthy, vigorous woman with a family histoiy free from predisposition to the disease becomes consumptive a few months after attendance on a consumptive husband, and dies from the same cause, tell more in favor of infection as a cause than any collection of statistics can against it. Moreover, the fact that many wives nurse con- sumptive husbands and do not become consumptive thereafter does not tell very much against the infec- tion theory. We explain this by supposing that such wives so live as not to give rise to a strong enough predisposition, urtd that the infection — the bacillus — in these cases may be less virulent; as it is well known that some bacilli are much more virulent than others, and will " take root " and act as disease germs in circumstances in which other bacilli will not. Austin Flint, in relation to 670 cases uf his own collecting, bearing upon the comuninicability of the disease between husband and wife, says, "In my collection of cases . . . five are all that I find in ITS NATURE, CAUSES AXD PREVENTIOX. 179 which there is room for suspicion" of the (^sease having been so communicated. And '* it nmsf,, there- fore, be concluded that the analysis of my cases does not furnish facts sufficient to render the communica- bility of phthisis probable " This simply means that it may be infectious, but Doctor Flint's cases furnish no positive evidence of it. Mays (before cited) does not give any statistics of his own but quotes those of others, and gives other evidence which in his opinion bear against the infection theory, in which he himself does not believe. Sir Benjamin War<l Richardson, M.]3., LL.D., F.R.S., editor of the Asclepiad, London, in that classic health periodical of April, '94, stiites that, aHhough he had determined in the early part of his professional career, aliout half a century ago, to " watch intently, without bias, and persistently," for evi«lence of infection in plithisis, and in all his experience, thousands of cases of the disease having come before him (for the most part dispensary patients), he had not found " i\ single particle of evidence" that "sustained the contagion theory," or, strange to relate, " gave on reliable data the least color to it." Sir Benjamin continues: "Phthisis pulmonalis will diisappear just as broad sanitary views are established and brought into practice. . . . Under the new conditions, with provision for a better heredity, in which cleanliness becomes the watchward, in which youths enjoy free exercise in the open air, and labor in confined places is reduced to a proper standard, the disease would die out altogether. ... It is quite practical to take care 180 CONSUMin'ION that the expectorated secretion of consumptives is destroyed. . . . But this is merely a matter of clean- liness, ... of perfect hygiene." '! 'i" t:V A DEGREE OF INFECTIOUSNESS FAIKLY ESTABLISHED. With all the v^eight of circumstantial evidence — historical, statistical, and clinical or individual — which we have in favor of the infectious nature or occasional communicability of consumption, together with the fact that the tubercle bacillus, which seems clearly to be, and is almost universally recognized as, an essentinl specific cause of the disease and as being present in all cases of it ; that inoculations of pure cultures of this bacillus or of tubercular matter will produce the disease in animals ; and that the disease has been frequently produced in human beings by the acci- dental inoculation of such matter in various ways, as in post-mortem investigations, injury from broken spittoons, etc. (Heron : Evidence of Com. of Phth.), it seems difficult to understand how anyone can doubt that the disease is in a measure infectious — that it may be, and sometimes is, communicated by infection, as commoidy urnlerstood by this term, — by active, virulent germs being conveyed directly from an infect<3d to a non-infected but susceptible person. To admit that the bacillus is an essential cause of the disease, and that the disease nuiy be caused by inocu- lation of it into the body of a susceptible person, is surely eijuivalentto admitting that the disease is com- municable in certain circumstances, and thereiori' ]M*aotically infi^ctious. 'ypw^ ITS NATURE, CAUSES AND PREVENTION. 181 What is the difference, let us here inquire, between infection and inoculation ? In the latter process the virus, or infection, is conveyed to the unaffected person (usually) purposely by a special instrument, and by it is pushed throu<;h tho cuticle into the fluids (blood or lymph) of the true skin ; in the former, the infection is conveyed in an acci<lental manner by air, food, etc., to the mucous membrane lining the inner cavities, and, as it were, finds its own way, or is pushed by some means, probably, through a break in tlie soft epithelium, or inner cuticle, into the fluids of fliis membrane. In the case of the more infectious diseases, the infecting particles are probably the more iiitiiiitely small, and hence the more easily get through a l)reak in the wall, or through a minuter one, and so tlie more surely and frequently infect. Doctor Herman Weber has said, now Bome years ago (1885, Croonian Lectures, Lon., Sect. 1), " We know that it [the tubercle bacillus] thrives in the bodies of most warm-blooded animals when inocu- lated; but this does not prove that it will find a nidus [nest or soil] in healtlr; tissue when merely brought into contact with it by siUTounding air." Certainly it does not. But as ah'oady has been inti- mated, this term " healthy " — whole, clean — practi- cally defines th(5 difference between persons who " take " the disease — become dir<>etly infected by it — and persons who do not ; and a want of health, or wholeness, the difference between infection and inocu- lation. With a break in the wall and unclean tissues, one becomes inoculated and infected. ht-r i< " 182 CONSUMPTION We may ask how many strictly healthy persons in this sense are there — with absolutely clean, pure tissues and fluids, whole and sound, with all the various bodily organs working in complete harmony, who do not provide intoxicating nutriment for the micro- organisms, or are able to resist their virulent action !* How many persons among the masses of the people are absolutely " healthy " on sucli a standard ? Very few. Yet is it an unreasonable, impractical standard ? It is not an impossible one. Hence it is one that may be fairly aimed at for both individuals and commun- ities. On the whole, doubtless, a good many persons are in the enjoyment of such a condition. Why should not many more, or all, enjoy it eventually ^ True, it is a standard not attainable and retainable without care and effort. But it is really worth more than the care and effort which would be usually required. In the present condition of the masses, with the much unhygienic housing, clothing and dieting, and with the consequent prevalence of catarrhal conditions, " colds," etc., a large proportion of the people doubtless present in the walls of their minutest bronchial tubes, defects or breaks — " nmcous abrasions, upon which the bacillus can settle," using Doctor Weber's words, when further on he points out how catarrhs may open a way for virtual inoculation with the bacillus. At the same time, from these and other unhygienic con- ditions, the tissues and fluids of many of these people ontain such an excess of dead matter as to provi<le all the conditions — the suitable soil, as already ex- plained — for the most rapacious, sapropyhtic bacteria, ITS NATURE, CAUSES AND PREVENTION. 183 and probably even for exciting or transforming non- vii ulent ones into true disease germs. What now, let us intjuire, are the clinical facts and pr<)l)abilities bearing on this point ? A consumptive person in an advanced stage of the rlisease coughs up and spits out vast numbers of bacilli : a fact that the microscope plainly reveals. These germs are often in a most virulent,, poisonous condition. Without the utmost care, attached to invisibly minute particles of mucous, tubercular matter or destroyed tissue, they get scattered about the sick person and bed. The in- visible particles, with the germs, soon — probably in a a few minutes — become diy enough to be carried with the air breathed into the lungs of an attendant. The germs have not been exposed to light and air long enough to have lost any of their vitality or virulency In the tissues and fluids of the new field — the new body, rendered susceptible or predisposed by long vigils, night and day, in probably a close, over- breathed atmosphere, with many months or a longer time of limited respiratory action and want of oxygen, and with a break or abrasion in the defensive wall of the mucous membrane of the minute brochi, the seeds Fall upon (to them) fruitful soil. Here, active, full of venom, — if the figure may be permitted, excited and gory, fresh from the battle-field — they set up, probably in spite of much resistance, the inflammatory action which results in the formation of tubercle. A case of this nature would be uncjuestionably one of infection or contagion, or, if another term be preferred, inoculation. Who can rloubt that such cases not infrequently occur? I IP i '■■i -1; 184 coi^suMrrroN A 'J- 1 i r III ill i' With these facts and' probabilities, and with the many special cases of the disease reported by various authentic observers as having had, seemingly, their starting point in this way, at the bedside, is it reason- able to deny or doubt the infectiousness or direct communicability of consumption ? Yet, neveiiheless, as we have seen, some physicians of high standing, apparently not many, still (juestion it. It seems to be clearly established, however, and now very gener- ally believed, that altogether in not a few cases of the disease, possibly in many in certain localities, countries or peoples, its gernis had been communicated, and by means of tlie atmosphere breathed, <lirect from a per- son affected with the disease, somewhat as above pointed out. The tlieory of the infectiousness of con- sumption, therefore,should be considered as established beyond reasonable doubt. The disease has been clas- sified with such other infectious diseases as typhoid fever and Asiatic cholera (Doctor Thomson : New York Acad, of Med.), as a " non-contagious connnuni- cable disease." It has been estimated that about eight hundred tubercle bacilli are necessary in ordinary circumstances for the successful inoculation of a rabbit. The number required to infect a human being couUl hardly be approximated, but would obviously vary greatly with circumstances, especially with the degree of virulency of the bacilli and the condition of the soil or host. !* CHAPTER IX. CAUSES OF CONSUMPTION CONTINUED. SOURCES AND DISSEMINATION OF THE BACILLI. TuiJERCLE bacilli, Jind doubtlt'ss their spores nlso, are given oft' from a consiiinptiv(» person most abun- dantly with the expectorated matter couj^hed U[) fn^n the lungs — the sputa (spit). In consumption of the bowels, they are given ott' witli the bowel excreta. There is evidence that they may be cast out by the perspiration, through the skin, and also with the lU'ine, and spores possibly pass ofi' with the breath. Tuberculous animals are a source of the germs. The flesh and milk contain them : and doubtless the various excretions also. With all these known sources of tubercle bacilli, who can escape taking them, sometimes, or often, into the body, either by inhalation or swallowing { There are, too, a number of vvavs in which these germs, whether active and virulent or dormant and non-virulent, are spread about — disseminated on every hand. They may then be conveyed to human bodies by air currents, especially with and forming part of the ubiquitous dust, and by solid bodies of almost any and every kind, — clothing, bedding, money, public IMAGE EVALUATION TEST TARGET (MT-S) 1.0 I.I 1.25 150 ■ess 1S6 JM m IIIIM \\= 120 1.8 M. 111.6 Photographic Sciences Corporation 23 WEST MAIN STREET WEBSTER, N.Y. 14580 (716) 872-4503 4is z f> /■ 186 CONSUMPTION : V'iS-: m conveyances, etc., etc. They are not known to spread by means of water ; but are doubtless often communi- cated to human beings by the milk and flesh of tuber- culous animals used as food. HUMAN SOURCES OF THE BACILLUS. The number of tubercle bacilli given off daily by some consumptive persons is so enormous that it would hardly be credited v/ere it not that they have been repeatedly subjected to actual count ; that is, counted in certain portions of the sputa. The number varies greatly with the nature of the case and stage of the disease. Twenty millions is about the lowest estimate. On the other hand. Osier (Prac. of Med.) records that a patient of his in the Johns Hopkins Hospital, Balti- more, Md., " moderately advanced," in sixteen counts, during a period of a few weeks in January and February, spat out from one and a half to four and one-third billions of bacilli daily, contained in from about a pint to a pint and a half of expectorated matter. Amongst every one hundred thousand of the population there are constantly, on an average, two or three hundred suffering from consumption. These people cast out thoughtlessly, carelessly, almost criminally, always most disgustingly, anywhere, every- where, just as temporary convenience suggests, or occasion and circumstances permit, or do not forbid — upon the floors of rooms and shops, public halls and other places of public assemblage, in public con- veyances, upon the sidewalks of the streets, and in back yards — countless billions of the infective bacilli, ITS NATURE, CAUSES AND PREVENTION. 187 besides their probably still more numerous spores. The sputa containing them soon dries, and, probably often encased in and protected by a coating of dried mucus, they are set free. What becomes of them, of these countless myriads of invisible particles ? They are carried by air currents hither and thither, lighting on our food and flitting with the breath we draw into our lungs. Samples of dust were collected by Cornet from many and various sources, especially from the walls and floors of wards and rooms which had been occu- pied by consumptives. Of one hundred and eighteen samples of that dust, forty were infective and pro- duced tubercle in animals inoculated with it. Prauss- nitz collected dust in covpes of trains running on a road frequented by consumptives. Inoculated into five guinea-pigs, the dust produced tubercle in two. In consumption of the bowels, too, doubtless enor- mous numbers of the germs are cast out by the fecal discharges, which eventually dry up and set free particles with living germs. Doctor E. Solles pro- duced tuberculosis in guinea-pigs by inoculation with the feces and urine of consumptive persons. Professor Graham says the bacilli have been found in considerable numbers in the perspiration. They adhere to the skin, and are not found when the surface is kept clean and disinfected. This would indicate that they come from other sources and settle on the skin. It is most likely, however, that they are washed out of the body by the perspiration. ^^ u'lli 5] J 1] 'It 188 OOXSUMPTIOX HOW THE BACILLI ENTER THE BODY : INHALATIOxV. There are four avenues by which tubercle bacilli may get into the body: (1) Inhalation — the air pas- sage route to the lungs with the air and dust breathed; (2) Swallowing — the food passage way to the stomach with the food, or when carried to the mouth or throat by other possiVjle vehicles, as the lingers, pins, money, etc. ; (3) By direct inoculation through the cutis, into or under the skin, as through a cut or scratch; (4) Congenital means, from a parent. From the fact that in tuberculosis the lungs are the organs nmch the most commonly affected, especially amongst adults, it is generally believed by authorities that inhalation by the air passages is the most com- mon way in which the germs of the disease are received into the body. Some writers have con- jectured difficulty in the germs thus reaching the remotest recesses of the lungs, but it is not easy to understand how there can be any obstacle whatever to their passage in, along with dust, which is so con- stantly breathed. That this is one way of entrance has been fairly proved by the experiments of Tappeiner and Bertheau upon dogs. The very beginning of tuber- cular formation, too, is often in the smallest bronchial tubes, which open direct into the air chambers. Next in importance is infection by way of the digestive tract with the food. The microbes may be conveyed into the mouth in various ways, perhaps by the air in breathing through the mouth, whence they are conveyed into the stomach by swallowing. A ITS NATURE, CAUSES ANJ3 I'llEVENTlON. 189 case has been recorded in wliich the water that 8ome grapes had been washed in produced tubercle in animals inoculated with it, the grapes having been outside the door of a fruit store, exposed to street dust. The most common vehicle, however, in which the infection is conveyed into the stomach is probably the tlesh and milk of tuberculous animals, an important part of this question to be presently discussed. Direct connnunication of the germs by nccidental inoculation is not a connnon method of sj)re{.ding consumption, although a large number of cases, in all, of this kind have been recorded. Doctor Heron gives details of many cases of such inoculation, in various ways. The disease has been communicated many times to man through a slight wound in making examination of tubercular dead bodies, of man and animals. Surgeons have sometimes suffered seriously in this way. Pfieft'er recoi'ded a case of a veterinary surgeon who, in 1885, was cut whilst making a post- mortem examination of a tubercular cow. The wound healed readily, but six months after, a small tubercle was found near the part, and some months later the man presented symptoms of pulmonary tuberculosis ; of which he died two and a half years after receiving the wound. A few years ago a case was mentioned in the British Medical Journal of a young girl who contracted general tuberculosis from wearing the ear- rings of a friend who had died of consumption, the infection having been apparently conmiunicated by way of the pierced ear. The communication of the disease by the parent to ft 'I ii Hi I ■ V ^\ 1' 'I , . If' , I V i 190 CONSUMPTION : the offspring has been already sufficiently discussed in connection with the subject ol' heredity. In whatever way the infection is taken into the body, it is conniionly spread to other and various parts of the organism ; and, it appears, by and alon^ the course of the lymphatic vessels rather than by the blood vessels. Whether the bacillus, after getting into the body, has any special predilection for the lungs, is not yet known. It seems evident, however, that in whatever way the infection gets in, if it give rise to tubercle, the lungs eventually, in nearly all cases, become affected with it. INTERCOMMUNICABILTTY : INFECTION FROM ANIMALS. That consumption may be communicated from man to the lower animals and from such animals to man has long been believed, and now appears to be a well- established fact. As already has been stated, tuber- culosis in the bovine race, once known as the " pearl disease," is now universally regarded as being identical with the tubercular disease in man. The bacilli in the two cases are indistinguishable under the micro- scope, while their growth in various culture substances attd their biological characteristics are identical, except that the bovine bacillus is usually smaller than that of man, although in cow's milk it is as large. There is conclusive evidence that the disease is conniiunicable from man to the domestic animals. Besides instances of observation in which it seems clear that poultry contracted tuberculosis by eating tuberculous expectoration from human lungs, the ft' «> f It.. ..> 1,'^ ITS NATURE, CAUSES AND PREVENTION. 191 i^ jcussed ito the various 1 alonji; han by gettin for the Dwever, it give sarly all •JIMALS. •om man 3 to man 3 a well- , tuber- |e " pearl dentical lacilli in micro- Ibstances ,1, except an that isease is I animals. It seems eating Ings, the disease has been proc* iCed time and time again in animals by intentional inoculation. As an example of probable conununication of the infection from the human body to animals, the follow- ing will be of interest. In the Lancet (Lond.) of Jan- uary 16, 1802, J. Armstrong, M.B., of Liverpool, Eng., reports that a boy, a patient of his, with a tuberculous family history, died at the age of fourteen, of con- sumption. He had a pet dog and a pet rabbit which were often about and on his bed during his illness. Both animals soon became affected with cough and died shortly after. A veterinary surgeon made an examination of the bodies and pronounced the cause of death to have been tuberculosis. THE BOVINE RACE A SOURCE OF THE BACILLUS. Doctor E. F. Brush, of Mount Vernon, N.Y., who is a stock raiser, and has long devoted attention to this subject, believes that tuberculosis " is all derived from the bovine race" (Paper, N. Y. Med. J.). He suggests that as the temperature of bovine animals is higher than that of the human body, the tubercle bacillus finds in them the most congenial soil. " We are veri- table parasites on the cow. . . . She has tuber- culosis and we have tuberculosis. . . . The inhabi- tants of the steppes of Russia, who have no cows, have domesticated the horse, using its milk, meat and skin, and a case of pulmonary tuberculosis has never been known amongst them. The Esquimaux have neither cows nor pulmonary phthisis." It appears, according to Doctor Brush, that where the dairy cow is unknown, -:i '"V :!«■* »• J ■•\iX li 192 CONSUMPTION : coriHUinption doe-s not prevail, but that on the other liand, the di.sea.se is connnon where tlie cow is in common use, and many countries are named to cor- I'oborate this. Evidence, too, that a certain amount of rehition exists between tlie prevalence of this disease in man and that of bovine animals is afforded by a chart issued in the year 1881 in Ba<len. The chart applies to fifty two towns, and shows that where tuberculosis was prevalent among cattle, it was proportionately prevalent among the human population, and was particularly so in towns in which the number of low-class butchers was greatest. In a debate in Par- liament in Great Britain, a few years ago, Sir Lyon Playfair pointed out that it is a " significant fact that when tuberculosis in cattle increases, consumption of some form or other — but especially of the mesenteric and intestinal form — also increases amongst children." All this at least affords evidence of the communica- bility of the disease from animals to man. FLESH AND MILK SOURCE OF INFECTION. Tiiat consumption could be communicated to the human body by means of the flesh of tuberculous animals used as food has been evidently suspected from the earliest records. There existed strict Mosaic laws condemnatory and prohibitory of the use of the flesh of animals affected with the disease. From that time onward to the present various ordinances have been instituted with the same object. It has been argued that there is no direct proof ITS NATUKK, (JAUSKS AND IMIKVENTION. 193 e other V is ill to cor- relation in man a chart , applies erculosis tionately and was iinber of ,e in Fal- si r Lyon fact that inption of lesenteric children." munica- lON. rect proof of the transmisHion of tubercle from animals to man l)y the use of Hesh and milk as food. Such proof, urtres Professor Walley (Royal Vet. Col. Edin.), " cannot, for manifest reasons, be obtained, but the mass of indirect proof in favor of such supposition is enormous." He mentions a striking example of the effect of eating tin; Hesh of tuberculous animals, hrought to light by a French physician, in the case of a younj( woman who rapidly became consumptive as the result of eatin^ij the imperfectly cooked bodies of tuberculous fowls. Doctor C. R. Drysdale, a few years ago, in the British Medical Journal, drew atten- tion to a fact in his experience, viz., that in the Metropolitan Free Hos[)ital, London, " it was very rare indeed, even in the poor Jewish quarters of Houndsditch, to meet with Jews afflicted with phthisis, a disease so prevalent among the ordinary population of that district." This exception is attri- huted to the care taken by the Jews in the inspection and selection of meat. The question of the infection being conveyed by milk is, perhaps, of even greater importance than is that of infection by flesh, for the twofold reason that it is so largely consumed by infants, and this generally in an uncooked state. The danger of con- tamination by milk will be more clearly compre- hended when it is known that the tubercle bacillus can be readily detected in the milk of animals in whose udders tubercular lesions exist; and also, as shown by Professor Bang, of Copenhagen, in that of women whose mammary glands are tuVjerculous. Of 13 HI i 194 CONSUMPTION ill' six hundred cows examined by Doctor Woodhead and Professor McFadyean (of Gov't. Bd., Gt. Brit.), in six cases they dernonstratetl the presence of tubercle bacilli in the milk. Professor Walley says, " In 1872 I lost a child in Edinburgh under circumstances which allowed but of one explanation, viz., that he had contracted mesenteric tuberculosis (consumption of the bowels) through the medium of milk." A Mr. Cox, of the Army Veterinary Department, England, has related the particulars of a case which led to the same conclusions ; as also has Mr. Hopkins, F.R.C.V.S., of Manchester. Fleming (Vet. Med.) has referred to a similar case as occurring in the child of a surgeon in the United States. Walley reports a case of mesen- teric tuberculosis from the use of milk which occurred in the child of a well-known veterinary officer of the Privy Council. At a meeting a few years ago of the Edinburgh Medical Society, Doctor Woodhead referred to some undoubted cases of transmission to man, and also to the pig, by the medium of milk. Many other cases of a similar character have been recorded. A striking case has been reported by Denune, of Berne (Med. Press & Circ). An infant aged four months, with no tuberculous tendency, died of tuberculosis of the bowels, the bacilli being found in the glands. The child had been fed with only milk from a cow which was then killed and found to have tubercles in the lungs, while milk pressed from the udder contained tubercule bacilli. Finally, quot- ing the words of Professor Adami (Paper, Montreal Med. Soc, Mar. '93), " Intestinal and abdominal tuber- ITS NATURE, CAUSES AND IMtEVEXTION. 195 odhead rit), ii> ubercle ^8, "In istances b he had )tion of A Mr. Sngland, ;d to the R.C.V.S., ferred to surgeon )f mesen- occurred ^er of the •8 ago of oodhead [lission to of milk. tave been »rted by n infant iiicy, died ,ng found ith only found to (sed from \\y, quot- Montreal lal tuber- culosis is most common, as we all know, in the young, and the prevalence of milk diet indicates wliat Bang in Denmark, Bollinger in (Germany, Nocard in France, and Woodhead and McFadyean in England, have con- clusively proved to be the case, tliat this intestinal tuberculosis is very largely brought about by the milk of tubercular cows." According to Bang and others, the cream, butter, cheese and buttermilk from tuberculous cows have been shown to be as infective as the milk, if not more so. It seems that the milk may be so sterilized as to render butter and cheese therefrom comparatively safe. It is possible that the spores may survive the sterilizing process. The only absolute safety is, prob- ably, in healthy cows or inunune human bodies. I m CHAPTER X. ■It ' m m ,1 K CAU8KS OF CONSUMPTION CONTINUED. 1>E NOVO ORIGIN OF THE DISEASE. Now as to wliother coiiHiuiiption always, frequontly, or only occasionally, arises by way of infection — communication by virulent jjfernis from another case of it — and if not always, in what manner do the other cases arise, is a very important cjuestion, and one which, so far as I know, has never yet hn'v specially discussed. In ordinary general pra'^-tice, we find but comparatively few cases at the most whicli can be traced to infection; not nearly so many as we can so trace in cases of outbreaks of typhoid fever, the least infectious of the febrile diseases. It will be con- ceded, probably by the most ardent advocates of the infectiousness of consumption, that at least many more cases of the disease develop by other means than by ordinary infection which can be traced. How or in what manner do these large majority of cases arise i DOES THE BACILLUS GROW OUTSIDE THE BODY ? We have seen that there is no consumption without the tubercle bacillus. It is not known that this bacillus grows outside the body of a living warm- blooded animal, except by cultivation in the labora- IIS XATl'UK, TAKSKS AND I'UKVKNTloN. li)7 aiRT). E. quontly, nfection another jr do the iion, aiul yet brf-'Ti )st which ,ny as we Ifever, the 111 be con- ges of the ,st many leans than ow or ill !S arise ^ BODY ? without Ithat this ig warni- le labora- tory; wliile it is hclit'VtMl l»y K«k*Ii ami ntlicr liioh uutliorities that it does not. Tliere is, liowever, doubtless nmcli yet to be learned in relation to tiiis micro-organism, especially as to its }>otanieal history. Sir Hu«^h Heevor has shown that it will ^row at a temperature of (K) F.: aIthou<fh it is generally sup- posed that it recjuii'es that oF O.')' or inon'. May it not, then, like 'lany other, if not all, disea.se jroi-ms, the life history of which is best known, pi"o})a<^at(; out- side a wann-blooded body i The bacillus of splenic fever (anthrax), as alv^'idy .stated, "ordinarily com- pletes its developmental c\ cle outside tlie animal body" (Koch); and the baciUus of tvphoid fever and of cholera probably (h. so, — at least they propai(at(! in milk and other fluids; vviile it is probable that the infective organism ol 'li})htheria is also of a like nature in this respect. The (question may be asked, is the simple, single l)acillus, or little stick-like and best known form of this fungus (the tubercle bacillus), the ultimate, com- plete, natural form or condition of the vegetation ? Probably not. Nearly all these simple forms of life have a more complex and complete state of existence, if only as a cluster or mass, even zooglo^a— a gluey or gelatinous clump or colony produced by most bacteria whenever they are allowed to flourish unmole:ited. We have seen that the star fungus in actinomycosis, or " lumpy jaw," of cows, presents a daisy-like form. Branched and other forms of the tubercle bacillus have been observed. And in what phase are these bacilli in the dull, whitish, scale-like growths on blood serum If r mi 198 CONSUMPTKJN : IM in the to.st-tubo ? Or vvluui appearinjj^, <«m Hall says, like " criiiiil).s of breatl moistened ; " or as a Klatsch preparation, with "a thick, curled-up centre around which threads are wound in all directions ? " It is not possible for the bacillus to take on any such form in its parasitic life in a livinj^ body because of the antagonistic vital forces of the host. Is it then, as Koch says, always a " true parasite " which " cannot live without its host / " Or is it only an accidental or occasional parasitic organism when in its simplest phase i Has it a more flourishing vegetative con- dition, approximating the mould formations, for example: — perhaps on "cultui-e media" of minute particles of human excreta, as sputa, and in dark, damp, secluded, confined spots in unhygienic dwellings, cellars or closets, or elsewhere, outside of dwellings ? In some such conditions the infection of diphtheria and of typhoid tever and cholera are supposed to lurk and flouri.-ih. Since these pages were vritten, and apropos to the above, I see in the British Medical Journal (Mar. 9, '95 : Epit. of Current Med. Lit.) editorial comments on "a detailed account" of the various forms of this bacillus and its biological position, by Coppen Jones, already referred to, as follows : " A number of observations are mentioned, which tend to show that bacteria . . . are only stages in the develop- ment of more complex forms. The author thinks we ought to hesitate before accepting the common view that the exciter of tuberculosis is a parasitic organism, which is transmissible only from animal to animal, and ITS NfATUIlK, ('AUSKS AND PIIEVEXTION'. 199 U Hays, KlatHch around It is not form in . of tlie tlien, as " cannot ccitlental simplest bive con- /lons, for f minute in (lark, dwellings, Iwellings ? liphtberia led to lurk ipropos to irnal (Mar. comments forms of 3y Coppen A number d to show |\e develop- thinks we inon view organism, Lnimal, and which i.s without vegetative exi.steTice external to tlie animal l)ody." Again, in a paper by Doctor Arthur Ransoine, F.R.S., in the Procecnlings of the Royal Society, Eng, (Vol. xcix.), "a series of observations are given to prove that fresh air and liglit and a dry sandy soil have a distinct influence in dinuuishing the virulence of the tubercle bacillus." " Mere exposure to light in otherwise insanitary conditions does not destroy the virulence " (Lancet, Jan. 16, '92). Now, why would the virulence diminish on a dry sandy soil, and not in " insanitary conditions ? " Is it because such soil affords no decomposing organic matter, as food for the saprophytic requirements of the fungus, such as aflbrd- ed by other soils, or insanitary conditions ? Why, if the fungus does not grow outside the living animal body ? We must bear in mind that reliable statistics prove beyond doubt that consumption is less prevalent on sandy soils than on heavy damp soils. Doctor Flick, who has long made a study of the subject of the in- fectiousness of consumption through the spread of the bacillus, says (Pamph. on Contag. of Phthis.), " I have no doubt that it [the bacillus] will propagate in decaying matter of any kind, and that it can thus perpetuate itself indefinitely." The opinion of Mr. Chandler, in his book on Prevention of Consumption — that it grows " free in nature," outside the body — has been already mentioned. Now, if this bacillus in another phase of its exist- ence, does not grow (and, it maj'^ be, best or most naturally) free in the open air, like most other fungi, K>'€?ViA il 11 200 roxsuMlTloX : and JiH in the cuhc of tlic .so-enlkMl uialai'ial j^ei'ui.s and thoHe of .splenic fever, it seems at least possible that in certain other and more favorable conditions, as in warm, dark, protected " corners," it may live a Ion*;- time and multiply or propagate its species. Possibly it may be a tropical plant an<l not yet fully acclimated to the frosts of temperate regions. A J'OSSIHLE LOWER ANIMAL ORKJTN. In considering the subject of the prevention of con- sumption, it seems necessary to consider possibilities, and, indeed, in practice, to act upon possibilities. There is, therefore, one more closely associated point to which 1 shall venture to refer in this connection. It may be generally looked upon as rather speculative, but perhaps in course of time it may receive more consideration. It has long seemed to me that all living so-called disease germs may have been derived through or from the lower animals. Such of the microbes as may have lived originally, like most known saprophytic organisms do, free outside a living animal body, have become, accidentally, occasional so- called parasites in certain of these animals ; and, it may be, only after, and chiefly by reason of, the less natural and more unhygienic conditions of the animals arising from domestication. If any there Ih' of the germs which never had so lived — free, outside the animal body — then, it may be, they were origin- ally, when in the animal body previous to domesti- cation, benign organisms, working out their destiny in the endless chain of events "which sustains the ITS XA'n'HK, (Al'SKS AND I'KKVKN'TroN. 201 equilibrium of nature," that notliiiio-, not (ivou a particle of excrement, Ik; loHt ; and because of the insanitary conditions associated with domestication they eventually become poisonous, virulent, parasitic, pathogenic. As we have seen, it has been suggested (Doctor Brush) that the bovine race mjiy be the original source of tiie tubercle bacillus, as it is apparently of the infection of vaccinia and small-pox. May it not be, if this bacillus never has been a free, air-growing fungus, that in bovine animals, in their more natural state, it is a benign oi'ganism or saprophyte, some- what as the bacillus coli communis is, usually, it appears, in man ? Reference has already been made herein to the remarkable effects on these micro- organisms of the diet and other conditions and habits of life of their host. May not the domestication of these animals, with the usual unventilated, often dark, dank and uncleanly byres in which they are housed, with want of more active, general, and fuller respiratory exercises, and their changed, more fat- forming and less invigorating food, have caused the degradation of the bacillus — the gradual " cultiva- tion " of it into a virulent, pathogenic organism ^ Becoming virulent and pathogenic in the cow, the tubercle bacillus, on being con\'eyed into the body of certain human beings, becomes perhaps still more poisonous and virulent. The (juestion may be asked, do not the methods, or the measure of success attend- ing the methods, by which it is now sought to protect man from the effects of disease germs — to render him ! '■ 202 CONSUMPTION immune — by inoculations with the diluted products of various mi^ioljes " cultivated " in the body of animals, whence possibly they came favor the view that man originally received them through or from these animals ? Again, it may be asked in this connection, what explanation can be given of the long period of so- called latency of the tubercle bacillus in the human body, and especially of the young — the period in which it apparently does no harm, as referred to else- where ? Is the microbe, then, absolutely inert, dor- mant, inactive ? Is it in a condition not at all in accordance with its nature ? Can this condition of it arise from any still inherent trace of its benign nature — be an instance of something like atavism ? We must await replies to these questions until we know much more of the botany of the plant. CONSUMPTION NOT ALWAYS FROM INFECTION. Now, whether the tubercle bacillus groM^s free out- side the living warm-blooded animal or not, or whether or not it comes to us wholly, or only in a measure, from the domestic animals, there is, in any case, at the present time a superabundance of the microbes and their probable spores scattered about everywhere by consumptive persons. They become dry, and the air and sunlight modify and eventually, doubtless, destroy their virulency, although not in all cases their life, especially in the case of the spores They are carried about with, or as particles of, the invisible dust of the atmosphere. Douglas Powell ITS NATURE, CAUSES AND PREVENTION. 203 id products le body of 3r the view igh or from Bction, what >eriod of so- the human e period in irred to else- iy inert, dor- ot at all in mdition of it : its benign ike atavism ? ons until we ►lant. FECTION. 3WS free out- or not, or or only in a re is, in any lance of the ,tered about They become 1 eventually, orh not in all the spores, icles of, the iglas Powell S4iys, " It cannot be doubted tliat tliey an<l their spores form some practical proportion of the organic elements of dust." Nor can it be doubted tliat most persons, if not all, occasionally, probably often, draw in with the air breathed one or other form of the microbe — the parent rods or their si)ores — by hundreds or thousands. They lodge on the cilia of the bronchial tubes, possibly on the walls of the air chambers : this without any harm or inconvenience whatever to a very large majority — from seven-eighths to three-fourths — of the population. With the min- ority — the rest of the people — however, it is quite different. In these persons who, we say, are in a sus- ceptible condition of body — predisposed to the disease — whose fluids and tissues are in a certain favorable condition, the inhaled bacilli or spores become again poisonous, virulent, and eventually tubercle — con- sumption, is produced. Should cases arising in this way be regarded as having an infectious origin ? The disease does not so arise in individuals in even fair or average health, and on exposure to the infection in a diseased person; nor, be it observed, from germs at the time virulent or infectious, apparently, for they do not infect the great majority of persons. The germs are not communicated as an infection in the ordinary way. They have Iqst in a measure, if not entirely, their virulency, or, in ordinary conditions, their infec- tiousness, by exposure to the oxygen of the air and to sunlight. A change has taken place in them out- side the human body. They are practically, even actually, in another state (if not phase) of existence. it ,.«,? ''I 204 CONSUMITIOX : They are not int'eetious until made so by a certain condition of, or something within, their host. In such cases we regard the disease as arising dc. novo — anew, over again : not without the essential germ, but from a transformed, modified, non -infectious one. We have the analogue of this in outbreaks, not infrequent in crowded parts of cities, of typhus fever. ** Given a sufficient amount of overcrowding, want of ventilation, and insufficient or bad food and typhfts is sun; to arise." I'he germs >>diich set up the disease " in a convenient soil are always present among us." They "only require the concurrence of the circum- stances" just mentioned (foul air and bad food) to " enable them to increase and multiply " (Carpenter). So, too, the germs of consumption are ever abundant around us, and only require t > meet with tissues and fluids surcharged with germ-food and probably toxic substances formed from the accumulated pro<lucts of imperfect respiration. OVERSIGHT AND ISOLATION NOT SUFFICIENT. Now, to what extent will notification and oversight, or isolation, with disinfection or destruction of sputa, prevent or lessen the frequency of cases of consunqi- tion arising in this way — practically, at any rate, <lr novo ? A certain amount of oversight for educational purposes, chiefly, would doul)tless be very useful. In time, only after decades, probably generations, of effort, the effect of such measures would be perhaps clearly apparent; hardly sooner. Consumptives, in the early stages, careless, indifferent, and also pur- ITS NATURE, CAUSES AND PREVENTION. 205 posely concealed cases — persons objecting to submit to even oversight — would continue to provide and .spread about myriads of the germs, which would con- tinue to be ubiquitous, almost as at tlie present time. Furthermore, it must be remembered, as above intimated, that in the application and exercise of preventive measures, in order to make sure of success, and the largest measure of it, we must be prepared for probabilities, and even possibiUties. It is at least possible that the tubercle bacillus may grow and pro- pagate outside the animal body. Of what avail then tlie destruction of the sputa? True, this point is met in a measure by general public sanitary administra- tion promotive of cleanliness, etc.: but in the case of a possible free, air-growing tubercle bacillus, met only to a very limited extent. Now, are we not forced to the consideration of the body factor, the " personal e(juation ? " This factor may be fairly, indeed must be, looked upon practi- cally and actually as the immediate, exciting cause of the disease. THE BODY FACTOR : — PRETUBERCULAR CONDITION. Reason leads to the clear conclusion that in the human body the tubercle bacillus (alike with other disease germs) is not "at home." The human body is not the habitat of the fungus. In an absolutely healthy human body it will not grow. The body in a certain diseased state, however, which may be termed a pretubercular condition, provides a soil — food, etc., and so causes the microbe to " take root " and propa- n-:H -m, 206 CONSUMPTION : gate in it. Something of the nature of this diseased condition, and the cause of it, it has been my endeavor in the foregoing pages to point out. Briefly, it is probably caused by, and is the effect of, certain toxic combinations or substances formed in the body from respiratory products accumulated therein by reason of a too limited respiratory function and con- sequent want of oxygen in the body ; somewhat as anaemia and chlorosis are effects of certain toxines formed from intestinal accumulations, and as a predisposition to typhoid fever or cholera, is caused, in all probability, by other of this class of toxines. We have, then, as the earlier effect of the limited respiratory function, this pretubercular condition — an actual diseased condition, indeed, which always pre- cedes the formation of tubercle. This condition is well and generally recognized, and has been termed the " pretubercular stage " of the disease, although the disease — tuberculosis — has not yet commenced. It is commonly looked upon as following, instead of pre- ceding, the first formation of tubercle. The symptoms, or signs — for they are more frequently observed by the friends than by the individual manifesting them — of this pretubercular condition are familiar to all. The three usually most noticeable are a certain amount of languor and depression with want of energy, a failure in the appetite for food, and loss of body weight. Sometimes me of these is first noticed, sometimes another ; sometimes, probably most commonly, in the order above named; sometimes the reverse. Treat a person in this condition with tonics, cod-liver oil ITS NATUKE, CAUSES AND ritEVENTlON. 207 aiifl other nutrient remedies, and he, or she, will probably improve for a time, or temporarily, with this treatment alone, but not permanently or in a marked degree. Induce such person to inhale an abundance of oxygen in the pure outer air, and in a few weeks of this out-door life, and often without any other remedy or change, the condition is replaced by one of health. The cause of the condition is hence plain. THE BODY CONDITION MUST BE PREVENTED. Sanitarians in their efforts to prevent consumption, and physicians in tlieir efforts to cure it, must recog- nize to a greater extent than heretofore this body factor, and overcome this condition. Indeed, in order to be most successful in such efforts, this factor must be regarded as the most important one, and be made the point of first and most vigorous attack. Prevent or remove the j)retubercular condition by increasing the respiratory function, and there will be no consumption ; but instead, most likely, good health on the part of these persons. Destroy and prevent the growth of the germs only, and this pretubercular condition of the body will develop into something possibly worse than consumption-^cancer, it may be, or other specific disease. Some other saprophytic micro-organisms will take possession of the rich soil and dwell in it, or make warfare there. We cannot live unhygienic lives and by simply destroying the so-called disease germs retain good health. W. Roger Williams, F.R.C.S., who for some years has given much attention to the relationship between consumption and w f 1 'A" III ~a« rf 208 CONSUMPTION : cancer, and promises a book bearing on the subject, writes as follows, although in a different order of sentences, in a recent number of the British Medical Journal (Nov. >], '94): "I regard the predisposition to cancer as closely allied to the tubercular predisposi- tion, of which in all probability it is but a diluted form. No heritable ccmdition is more favorable to the development of cancer than that which predis- poses to and accompanies tuberch;. A large proportion of cancer patients are the surviving members of tuber- culous families. The great increase of cancer during the last half century has coincided with a remarkable decline in the death rate from tuberculous diseases, especially phthisis. It seems to me exceedingly prob- able, from considerations deriv^ed from the study of the family history of cancer patients, that a large proportion of those thus saved from tubercle eventu- ally perish from cancer and insanity ; and I think the increase in the latter disease has been largely brought about in this way." DEDUCTIONS : CONCLUSION OF PART I. The following are my conclusions deduced from the facts and inferences set forth in the preceding pages : 1. That the tubercle bacillus is an absolutely essen- tial factor in the causation of tubercular pulmonary consumption. 2. That the tubercle bacillus will not propagate or give rise to consumption unless there be already in the body tissues special soil-food for its growth, and ll._ ITS NATUUK, CAUSES AND I'HEVENTIDX. 209 also, apparently, .some special morbid condition or Hiilistance, probably a toxine, which is essential to its action as a pathogenic parasite. 3. That this special soil-food and probable germ excitant, or tissue irritant, are produced fn the body from the decomposition of waste, effete matters ac- cumulated therein by reason of the respiratory func- tion being below a certain proportionate health standard, with a conseciuent limited supply of oxygen. 4. That the tubercle Vmcillus manifests various degrees of virulency, and in certain conditions, as when recently from the lungs ot a person in an advanced active stage of consumption, it may infect a susceptible person much in contact with such con- sumptive, as in the case of a devoted nurse ; also, when in flesh and milk in a recently virulent state, it is liable to infect susceptible persons using these sub- stances as foods : many more cases of the disease, how- ever, arise, practically, de novo — from revived or transformed non- virulent germs — than arise by such form of infection. 5. That the practical point is, not so much the pre- cise nature of the immediate cause of the pretuber- cular condition, or body factor, as that this arises from, or by reason of, a diminished respiratory function, and is, rather than the bacillus, practically the exciting and more controllable and preventable cause of the disease, and should be so regarded in preventive effort. True, a new field for preventive work is above in- dicated ; yet one not so difficult of successful cultiva- tion as some may suppose, or on first view it may H PI 210 CONSUMPTION : i ,1 J si2 !!'fl I'!;! II i'!;| appear io be, as I hope to be able to show in future pages herein, when on the .subject of prevention. The fact is, millions of the units of the human family die, primarily or remotely, and literally, from " want of breath " — from a want in relation to breathing — die after years of suffering from this cause. In the present condition of the masses of the people, with the limited character of many occupa- tions, amongst nearly all classes, so many being em- ployed in-doors and at work in which a stooping lung- contracting posture is temporarily the easiest, there is a consequent, connnon, almost universal, limited breathing movement and function. From this, alf> r with the too common practice of almost con.stantly breathing an in-door, already overbreathed atmosphere, deficient as it is in oxygen as well as befouled, a large proportion of the masses, while suffering from rebreath- ing the poison in such atmosphere, suffer incalculably from a want in the body of that most vitalizing, purify- ing, invigorating element, oxygen, and the con.seijuent retention of waste matters in the blood, obstructin<( all the vital functions. They are deficient in that vitality which a sufficiency of oxygen (aptly, in the beginning, by its discoverer, termed *' vital air ") gives, and which in turn gives zest and enjoyment to life and makes it " worth living ;" while they are, too, from the same cause, predisposed, and too often fall ready victims, to various other forms of disease as well as to consumption. They are poisoned by their own excretions — their own used-up, waste iritters retained in their body. So consequently tluv ITS NATURE, CAL'SES AND PREVENTION. 211 .mitter on, and eventually die, from a want of that I'UMiient which, when properly eon.sunied and utili/A'd, ^iveH general healthy, vigorous, unobstructed func- tional activity — briefly, from " want of breath." It is true, there are many other concomitant or conjoined causes which aid in bringing about this depressed, half-alive, specific disease-producing condi- tion of so large a proportion of " civilized " mankind. The foul air is never quite alone in causing disease. It has many confederates. Boon conjpanions of it are, commonly, an unclean dormant skin, improper diet — badly prepared, badly cooked and excess of food, darkness and dampness in dwellings, incontinence, tobicco and whiskey. Still, however, the rebreathing, again and again and again, the already breathed and rebreathed air of closely enwalled, unventilated sleep- ing, living and working places and schools, and Itreathing such an atmosphere with but small or C(mtracted or half-used lungs — in short, the imperfect performance of the all -important function of respira- tion — incomplete exchange of bodily waste for oxygen, is c6mmonly the starting-point of the too generally <lepressed vitality and want of full health and vigor among the masses, and of many other ills as well — intemperance, insanity and crime — which follow. The most marked, probably the greatest, health want of the age is fuller, freer breathing of purer air. II I PART II. PREVENTION OF CONSUMPTION. CHAPTEK XL The prevention of consumption is the special object of this book. It is not the intention that the pre- ventive measures to be discussed shall be applied only by and to individuals, or that each indi- vidual alone may be able to prevent the disease in his or her own person. There is a much broader aspect to the question, to be kept in mind. It is a great public question, involving indeed the eventual stamping out altogether, practically, of this most destructive of all diseases. The motto, the rallying crv, of sanitarians and all who are interested in the public welfare, or in their own health and that of those near and dear to them, should be prevention, always, on every hand and in every way, rather than cure. Philanthropists give large sums of money for hospitals for the treatment, with the intention of cure of disease, too often, alas, only the intention, how- ever laudable, many cases being too bad or reached too late. Who will be first to give of their abundance such sums for direct prevention ? ITS XATr'HE, (ArsES AND ntEVEXTlOX. 213 PIlACTICAhiLITY AND FACILITY OF FUEVENTION. • Particularly in respect to consumption is preventive rather than curative effort desirable : and For two reasons: tirst, because of the great fatality and im- mense pecuniary cost of the disease, and second, because of the comparative facility with which it may be prevented. It is, indeed, sini^ular that more special t'rtbrts have not been made by sanitarians in behalf of its prevention : one-fifth or more of the human race, as already stated in the introductory, being destroyed by it alone, in its various forms, besi<les its prevalence in domestic animals; while from the long periods of debility and sicknes^s to which it gives rise, the loss of time and nioney outlay are much (jjreater than from any other disease, and all this besides the direct personal suffering and l)ereavements from loss of relatives, commonly in manhood's or womanhood's prime. Consumption is comparatively easy of prevention because (a) the body factor in its causation being essentially more specific than in most other infectious diseases — the seed recjuiringa more special fitting soil in which to grow — its intended victims may be in a large measure picked out from amongst the people and the armor of prevention thrown around them : and (6) because the seed or germ is comparatively easy of destruction. Howard Marsh, F'.R.C.S. (of St. x^arth. Hosp., Lond.: in Brit. Med. Jr.) recently said, "Pro- gressive and destructive as the tuberculous |)rocess is, when the tissues which it involves are suitable for its :l i ■\u Uf' m\ ii \'\ !i« Ii »' It; i ^'i I! Ii 214 CONSUMPTION : development, and when its environment is favorable, the tubercle bacillus is, nevertheless, an organism of such low vitality, and so dependent on surrounding^ conditions, that it is frequently placed by influences with which we are at present imperfectly acquainted, at a fatal disadvantage, and thus is destroyed and eradicated by the vital forces by which it is opposed. That it does frequently, as a matter of fact, thu.s perish, is well known." Destructive as the bacillus is when associated with, or stimulated or poisoned by, man's unliygienic conditions, habits and surroundings, its effects are usually after all but a mild, timely, slowly acting penalty for sanitary transgressions. Without the unhygienic conditions, it would probably be as harmless as the simplest moul^ . That the predisposition to the difbc^.ie in individ- uals, whether inherited or acquired, may be in almost all cases comparatively easily overcome and removed is well known. It would be easy for me to give thf detailed history of many individual cases, as doubt- less it would be, too, for most other physicians, in which a strongly marked predisposition — even the pretubercular condition — was entirely overcome in a comparatively short time by careful, well-directed hygienic measures. In England and Wales, by the usual public healtli measures for the prevention of disease generally, the mortality from consuntption was reduced in a period of about twenty -five years (1864-88) by nearly one third. By more special general and personal pre- ventive efforts, doubtless the mortality could be much more largely reduced in a few years and eventually ITS NATURE, CAUSES AND PREVENTION. 215 the disease practically eradicated. In armies and navies, too, in Europe the prevalency of the disease has been greatly lessened by means of provision for more pure air, alone — more space in barracks and better ventilation. Who then will be first to start a fund for the timely prevention of this " great white plague " ? — let us say for building sanitaria, or a sanitarium, even one as a model, for practically teaching people to stand erect, as by nature or the Creator designed ; to breathe properly and freely of only pure, sunny air; to cleanse and invigorate their body by means of baths and suitable exercise and food as wel/ as by oxygen : for teaching them how to remove and prevent the predisposition — the prepared, fitting soil for the tubercle bacillus — a soil so prevalent on every hand and especially among the less well-to-do and less educated of communities who are not in a position of themselves to so help themselves; for teaching them, and perhaps first of all, the intrinsic, pecuniary value as well as comfort of good health. Unquestion- ably it is in the badly formed, badly functioned, im- pure human bodies, and not in the simple fungoid plant, that the root of the evil lies, and where the axe must be laid ; and it is quite practicable to suc- cessfully strike at the root. PRINCIPLES OF PREVENTION: LINES OF ACTION. The question then is, how may consumption be most effectually prevented ? The principles of pre- vention may ))e largely inferred from what has been recorded herein respecting the causes of the disease. i.n ,««' 1 ^6 CONSUMl^TIOX It will be remembered that in its causation there art; two chief or primary factors, namely, (1) the tubercle bacillus — the infecting agent, and (2) the special morbid body condition in which onlj'^ the bacillus will grow and give rise to tubercle ; in other words, the seed and the fertilized soil. In prevention, the aim must be to remove or destroy the causes. While we endeavor with one hand to destroy the bacilli, with the other we must endeavor to purify, invigorate and fortify individual bodies in order that there shall be no fit soil in which, by the growth of the bacilli, tubercle can be produced. It appears to me that greater success in preventing consumption, particularly, while preventing other diseases, too, will be attained by keeping in mind, rather than the bacillus, the thousands of defective human bodies which provide the condition — the soil — for its growth therein ; and by marshalling oppos- ing forces mainly against the causes which give rise to this body condition, whether inherited or acquired. Let us then first consider, as being the more impor- tant, methods for preventing the production of that particular, defective state of human bodies which is essential for the growth of tubercle bacilli, — how^ we may best combat the development of the so-called " predisposition." Public iiealth bodies, as well as individuals, must give more attention to this personal or body factor. It will be my endeavor to point out in future pages how this, in particular, may be best and most prac- tically done. ITS XATURE, CAUSES AND IMIEVEXTION. 217 PURE IMl'REGNAHLE BODIES FIRST. Up to the present time, special measures for the prevention of consumption have been ahnost entirely confined to destruction of the bacillus, and the body cause has received little or no attention. If we bear in mind that a consumptive in a " moderately advanced " stage of the disease has been known to give off daily in the expectoration from the lungs —in the spittle, by actual count (in a given proportion), four billions of bacilli, besides probably countless in- visible spores, and not including other sources of the germs, as the domestic animals and a possible open- air growth, we can readily see that destruction of these is indeed " no easy task." This is not so much the point, however. At any rate, extermination of infections, or seeds, should go on. The late Sir Andrew Clark (lect. already mentioned) said, " Would it not be infinitely better for us to spend less of our time in what seems vain attempts to destroy those microphytes and more of our time in studying the character of the soil in which they will or will not grow !* For all my experience points to the conclusion that it is mainly, if not entirely, through the influences which we may become able to exert upon the soil that we may best hope to control or to stay the progress of phthisis." Professor BLackader (of McGill) says, " We feel c(mvinced that nmch more can be done by us as physicians in the way of prophylaxis by strengthening the barriers that nature raises against the intruders, than can be effected by any '< :' 1 '■'u- :i i! 218 CONSUMPTION or all of our subsequent therapeutic, antiseptic or germi- cidal measures." Doctor Burt, already cited, believes that, *' In dealing with the disease, r' is of primal consequence to keep in view the goal for which we may reasonably strive, namely, to elevate the tone of the tissues and the fluids that bathe them to a sani- tary pitch, where they themselves are the best of germicides. Bacteria do not thrive upon such nourish- ment." And Doctor Carmichael (Exam. Pub. Health, Fac. Phys. and Surg., Glasgow) says, " Secure cleanli- ness, purity of food and of the air of houses, schools and workshops, and consumption, finding no fitting soil, will disappear." In brief, the prevention of consumption consists principally in means for promoting good health and vigor — purity and tone of tissue, amongst the masses of the people. With the highest authorities, although for the most part looking upon the disease as infec- tious, the destruction of the infection — the bacilli — about which so much is being said and written, is of secondary consideration. The body factor is first. Furthermore, as the reader has been already re- minded, by improving the health of the masses individually, they will be enabled to resist the inroads of other infectious diseases, as well as consumption in its various forms ; and, indeed, all diseases, even chronic " local " affections of the different organs. Again, on the other hand, if we can materially reduce the mortality from this disease by extermina- tion of tubercle bacilli alone, there w411 probably be a ^'a' . f, ■-'■ ITS NATURE, CAUSES AND PREVENTION. 210 )tic or germi- ited, believes is of primal Dr which we 3 the tone of m to a sani- the best of such nourish- Pub. Health, ecure cleanli- ;)uses, schools uir no fittintr )tion consists cl health and st the masses ties, although ease as infec- -the bacilli — written, is of or is first. already re- f the masses st the inroads consumption iseases, even t organs, m materially >y extermina- probably be a proportionate increase in mortality from some other disease or diseases. Doctor E. P. Hurd remarks (ann. meet. Am. Climat. Assoc, '91), " Knowing that tuber- culosis is simply a blight which smites imperfecth/ nourished tissues, I would urge that the eflbrts of the therapeutist [and sanitarian] be directed to the (ilement of cellular weakness rather tlian of chasing the will-o'-the-wisp of a bacillus. Evict one hungry brood, and another more voracious and more malig- nant will take its place." In England, although the mortality from certain diseases has been reduced, from others it has about proportionately increased. As W. Roger Williams has pointed out (already cited), the increase of cancer has coincided with the decrease of tuberculosis. While there has been a large reduc- tion there in the total mortality, from all diseases, this has been, it appears, almost entirely from prolonging the life of very young and less vigorous persons ; and mostly by protecting them from infectious diseases. Let me here repeat, we cannot have much success in the prevention of disease simply by destruction of so-called disease germs, while we continue, either as individuals in our own personal private acts and practices, or as communities, to transgress the laws of health — to live in our daily, hourly habits unhygienic lives — while we continue to provide in our bodies impurities — soil, for the growth of the germs. So in- finitesimal are these and their spores, and so rapid their multiplication, they will continue to elude us and fall upon and grow in any good soil presented. Wherever 220 CONSUMn^TOX m on the earth's surface there is " waste " soil, there weeds, from seeds tlie sources of wliich are often un- known and unknowable, will spi'ing up, and spring up in spite of us; hoe them down, nip them in the bud, anH they come up again or others spring up. Somewhat so it is with the seeds of disease. Sometimes when we desire to prevent the growth of weeds or grass through a gravel walk in our lawn, we endeavor to destroy the fertility of the soil beneath. Let us act on a like principle in our efforts to prevent disease, particularly consumption, the seeds of which are S(j peculiar in respect to body soil. Where the carcase is, there will the vultures be gathered together. As individuals, Doctor E. Brown says, " We ought to learn to keep our bodies as invulnerable to contagion as a fireproof building is impervious to fire ; that is, we should be able to resist such moderate quantities of disease germs as we ordinarily and necessarily encounter through life. While I would not detract one iota from the oft repeated cautions to avoid the external sources of contagion, I yet believe the mys- tery why one person escapes while another under the same exposure becomes a victim to contagion, is explained in the fact that one carries such a store of vital energy and pure blood that no lodgment for disease germs is found ; while another by the im- purities scattered through blood and tissue, invites disease to enter." And in the words of the Medical Record (N.Y.), "There is no greater protection against disease than a good physical condition, in which the stomach craves and digests food, the intestines, the Silliill ITS NATURE, CAUSES AND PREVENTION. 221 >il, there )ften un- pring ii}) bud, arul Dinewhut es when or grass ieavor to et us act ; disease, ;h are so ;arcase is, ; ought to contagion ; that is, ][uantities ecessarily detract ivoid the the mys- ler under tagion, is a store of ment for the im- e, invites Medical ►n against hich the itines, the kidneys, the skin, and the lungs remove waste pro- ducts promptly, the liver elaborates the crude nutri- ent material into the finished product ready for use in construction and repair, and secretes in abundance the antiseptic bile ; and, in short, the whole economy acts as one compact and well-disciplined army, with all its branches — the cavalry, the infantry, the artil- lery, and the engineer corps — working in harmony, each with the other, and each in its own particular sphere. Bacilli may then attack, and micrococci may marshall their forces in vain, the liuman citadel is impregnable, and tlie garrison within lauglis at the liHputian host which seeks to do it battle." It is to be feared that before any great success will result from the efforts of public health boards or other authorities to reduce the mortality or improve the standard of public health, more attention and care will have to be given in some w^ay to the hygiene of individual bodies of all members of com- nmnities, old and young — to personal hygiene. This is entirely practical so far as instruction of the people in health requirements can be carried out ; and most can be done, and doubtless, too, a very great deal, in this line of action. It is hardly more practicable to insist on good plumbing than on good ventilation. Public baths convenient for almost everybody would incalculably improve the public liealth. And through the schools much could be done by special measures for preventing asymmetry of body, and particularly and easily, between the lungs and other parts. « •# II J-f •f^K 222 CONSUMPTION ATTENTION TO MINUTE DETAILS. Now, while it is most desirable to avoid anxiety or worry, in any measure, about the health or the con- ditions which favor or interfere with it, it is, never- theless, very desirable, especially for persons in any way predisposed to consumption, to give habitual attention to every detail relatir»cr to those essentials of health which will presently be discussed. To some persons this is natural, while many others are indif- ferent or careless and consult mainly their tastes and inclinations. An act or neglect, perhaps seemingly of little or no consequence, or a habit seemingly doing no harm, may exercise a decided influence on the functions of life, especially in a susceptible deli- cate constitution. It is well known that it is not uncommon for one or other of the body organs — kidneys, stomach, spinal cord — to become the seat of considerably advanced "local disease," possibly already incurable, from some act, or seemingly harmless habit, of the individual, as in respect to diet, occupation, sexual relations, or perhaps breathing, before any symptoms sufficient to attract attention are m;inifested. That eminent abdominal surgeon, Mr. Lawson Tait, on addressing a meeting of the Canadian Medical As- sociation, in reply to the question, — to what he attri- buted his success as an operator, said, in effect, to giving the closest possible attention to minute details in everything relating to both the previous condition of the patient and to the operation, especially as to {ibaolute cleanliness, So it should be with individual ITS NATURE, CAUSES. AND PREVENTION. 223 habits and surroundings as they hear upon liyjijieno. SoiiietiuieH in susceptible non-vigorous persons, and in others, too, the living out of the natural span, or even perhaps for a day, depends upon the condition of a few blood cells. Sometimes there are but a few of the most elementary particles between life and death : life "hanging" upon even less than "a thread." Respecting the struggle which may take place in the human body between the natural forces and invading germs. Doctor Lauder Brunton says, " The result of the struggle may be determined, not by some powerful agency which weakens or destroys either the organism or the microl>e, but bv some little thing which simply inclines the scale in favor of one or the other. In the potato disease the victory of the invading microbe and the destruction of the potato, or the death of the microbe and the health of the tuber, may depend upon some condition of moisture or possibly of electrical change in the at- mosphere which aids the growth of the microbe dis- proportionately to that of the potato. The conditions need not necessarily be antagonistic to the potato ; l)ut if they help the microbe more than the plant, the microbe will gain the victory." In like manner it is with the human body — with its unfelt and unknown physiological conditions, and disease germs. On the other hand, — as a little indiscretion some- times weighs down the mortal end of life's balance, so a little extra effort in respect to the essentials of health — a little watchfulness, prudence, temperance, on be- half of our physical organism, easy enough to practise '■ s; 224 CONSUMFflON : after a (leterniined endeavor and start, may brin^' down the other end — health, comfort and a prolonged and useful life. After having obtained correct knowledge pertain- ing to the rules of health, then nearly all the refpiire- ments come within the range of two mental charac- teristics, — self-denial and resolution: self-denial, by which there is no further gratification of any one of the appetites or passions than is in accordance with the strictest temperance, in all things ; resolu- tion, by which there is no neglect of duty in this behalf, and regularity in the practices or habits of hygiene — out-door exercise, bathing, etc. DIVISION OF THE SUBJECT. All means or measures for the pre ^^ention of con- sumption may be considered under three heads : first, general measures by which the essentials of health — pure air, proper food, means of cleanliness, etc. — are provided for the entire population — for everybody ; second, special means applicable to persons who hav(3 inherited or acquired a predisposition to the disease, who have the limited breathing capacity with the general well-known features, already enumerated, of the predisposition; third, means for preventing the forioation of tubercle in persons who have already acquii'ed the pretubercular condition and are on the verge of tuberculosis, commonly heretofore regarded as the commencing stage of the disease, with loss of the usual amount of energy and, perhaps, of appetite for food and of body weight. For the most part, the ITS NATUUE, C^\1;hES AND PREVENTION. 22r> preventive ineasureH come within the scope of official liealth authorities ah well as of individuals. Many of them, indeed, can only bt; provided and carried out practically and completely by united effort, as by state or municipality, and ceHain state preventive measures will, therefore, be ccmsidered. Fii-st, we will consider in detail those essentials of h(»alth and life which should always be provided for tlie masses of the people. Although relating to general sanitation and hygiene (as these two terms are now used in a somewhat different sense, although both have in the original the same meaning), a good, prac- tical, popular knowledge of such essentials is indis- pensable to the successful preventi(m of consumption : consecjuently they must receive attention in a work of this kind. All persons in any way predisposed to this disease, especially, should give them practical consideration, and, as far as possible, personal appli- cation. 15 CHAPTEK XII. GENERAL ESSENTIALS OF HEALTH. PURE FRESH AIR FIRST. .f- j) i III if & f- Tf! Air may be regarded as the first essential of life in the higher animals, as pure air is that of health. The evil effects upon the human body of breathing impure air have been sufficiently dwelt upon in Part I. : the evils not only of air which has been overbreathed, especially, but of air rendered impure by other insanitary states — from foul gases, dust and damp air — and how such air interferes with the im- portant function of respiration. Pure air is indis- pensable to a perfect respiratory function. For the most part, or so far as we are practically concerned, air impurities arise from man's own acts — overcrowd- ing in dwellings and accumulations of waste products of life in and around them. The soil upon which mankind live should be dry and clean, well drained, and kept free from all waste, decomposing substances on its surface, otherwise the surrounding air cannot be pure. Heavy, retentive, undrained soils are less salubrious than those which are dry. It would be well if there were some legisla- tion for preventing the construction of dwellings upon damp soils, such as some towns are built upon, ITS NATURE, CAUSES AND PHEVENTION. 227 until after thorough drainage. Marshes and swamps fire naturally shunned. The back yard as well as the front of all dwell- iugs must be kept free from decomposing substances, excess of slops and the like. It should give growth to a crop of» clean, healthful vegetation — line grass, flowers, shrubs, and not foul, rank weeds. " Back yards," as commonly found and understood, should be entirely done away with ; as also should the too com- mon low parts, kitchen and sheds — the " tail " ends — of dwellings, which extend l)ack into yards, and are rarely kept like the front parts, within or without. The back yard should be as nicely kept and as pre- sentable as the front, or more so. DwELl.lNG-HOUSE conditions essential to health are so concisely pointed out by Doctor Thorne Thonie, in a paper on the Dwelling-house in Relation to Consump- tion (St. Barth. Hosp. Rep.), that I again take the liberty to quote his words, as follows : " 1. A soil [for its foundation] which is dry (a) naturally; or (6) freed by artificial means from the injurious influence of dampness, and of the oscillations of the underlying subsoil water. 2. A dwelling-house so constructe<l as to be protected against dampness of site, foundations, and walls. 3. Such open space on at least two opposite sides of the dwelling-house as shall secure ample movement of air about it, together with its free exposure to the influence of sunlight. 4. Such construction of the dwelling-house as will secure for its habitable rooms and throughout its interior free movement of air by day and by night, and the free 'f i! li I W- £j^r ^' •'^r Mr 228 CONSUMFnON : access of daylight " ; — i.e., means for good ventilation, with abundance of windows unobstructed by curtains. The necessity for perfect house drains and plumbing to prevent air poisoning need not be dwelt upon. The CELLAR as commonly constructed should be also abol- ished. Cellars should be as scrupulously clean, dry, well-lighted and ventilated as any other apartment. The bedroom, as a place where a third part of one's life is spent, is deserving of special construction and care. The small, c^ose, badly lighted rooms in which some fairly well-to-do people sleep are a dis- grace. Want of knowledge as to the requirements of health can alone account for such rooms. A bedroom, for even one person, should be large, well ventilated and exposed to sunlight. The dread many persons still have of keeping a window open even a little is also from ignorance on the subject. NiGHT air, so feared, is vastly better and less dangerous than the breathed air of nine-tenths of the bedrooms. A window open all niijht even in cold winter weather can do no possible harm if the bed, with abundance of clothing, be placed aside from any direct draught of cold air. In very cold weather and for feeble persons, provision must be made for changing the body clothing night and morning — for going to bed and getting up with- out chilliness or too great discomfort. Aside from this, the cooler the sleeping-room one is accustomed to the better. If necessary the bed may be first warmed, as by a bed-warmer. W'len in bed anyone can keep warm with plenty of clothing under and over the body. Tenement houses are not infrequently in a danger- ITS NATURE, CAUSES AND PREVEXTIOX. 220 tilation, iurtaiiiH. lumbing )ii. Tlie l80 abol- ;an, dry, tment. part of jtruction :ooms in i-e a dis- ments of bedroom, lated and sons still ie is also JO feared, breathed ow open do no clothinj^, d air. In 3rovision n^ night up with- ide from tomed to warmed, can keep the body, a danger- ous atmospheric condition. In selecting one, much care should be exercised ; and investigations made respecting its general construction — walls, drains — and the health of its previous occupants. Remember, the infections of consumption, as of other diseases, may adhere to inner walls. 1 f any doubt, thorough cleansing and disinfecting would be the wise course. A brief record should be kept by health authorities of all tenement houses as relatinj; to sickness and death in them for public reference. Offices, shops, factories and schools should be closely looked to, even by those who are to occupy them, or by parents, as being most directly interested : particularly in respect to ventilation, drainage and any previous infection from the sputa of consumptives, or other disease. A recorded instance in which thirteen clerks, employed in an office in Paris, died of con- sumption in four years, attributed chiefly to infection from sputa, is mentioned in a previous page. Want of knowledge, carelessness and indifl'erence, on the part of proprietors of working places, have sometimes given rise to most serious consequences. Proper official inspection of all enclosed places where even but a few persons are employed, and of schools, should be provided for. Dust, as produced in certain manufactories, and even in many shops, or " stores," should be properly disposed of. Respii'atory appliances for straining the dusty air, through cotton, wool, crape or feathers, at best, soon get clogged and are of little use. Free ventilation with fans and fl\ies for aiding a strong out current are the best means for dust disposal. i \ 13:. I'ni i h r>y, i! U 230 coxsuMPnoN : VENTILATION : ITS IMPORTANCE, COST, ETC. Pure air and ventilation are almost synonymous terms. We cannot have pure air in enclosed places without ventilation — change of air. After each breath — inspiration and expiration — there is a pause of a few moments before the next inspiration, as if to give the air just expired time to dissipate or be removed from near the person before the next inspir- ation. Out of doors, where there is always some mo- tion of the air, change takes place readily. In closely env/alled places, if there be no means of ventilation, it is quite different. If a man go into an ordinary closed-up room, the air of which is as pure as outside air, in a few minutes, from the twenty-five or more cubic inches of foul, poisonous air he every three or four seconds empties into it from his lungs, the air is that much from being as pure as the air outside. How would it be if he remained in it an hour or two, or eight hours, without means for changing the air ^ or in case of a diseased man, in which the air is usually fouled more rapidly ? The physician advises his patients to " take fresh air," to " go out " or " keep out of doors." In many cases it is practically impossible for them to do so. Let them be advised, helped, shown how, to " take the fresh air " — the " out-dooi's," into their dwellings, much more freely than is now usual, with abundance of sunlight, too. This they can usually contrive to do when they cannot go out. The Cost of ventilation, of constantly changing ITS NATUIIE, CAUSES AND PREVENTION. 2in re. >nymous id places er each a pause , as if to ,e or be :t inspir- ome mo- n closely [itilation. ordinary s outside ; or more ' three or the air is de. How two, or the air i* he air is ike fresh n many to do so. " take wellinga, jundance ive to do changing warm breathed air for fresh, is the great obstacle. But it is much easier and better to pay for extra fuel tlian costs of sickness : better a fresh air bill than either a meat or a medicine bill. Householders and others should count on this as on any essential of Hfe; and rather first of all : make it the first item in estimating living expenses, — extra fuel for warming ahundance of fresh out-door air. If necessary, cut oflf some luxury, as of clothing, or even of meat, in part, or tea or coffee ; but provide for pure air. Thk methods of ventilation cannot be entered into at length here. The first principle, however, is to let out or draw off' the breathed air to make room for the fresh. If a strong enough force or draught be employed to draw foul air out of a room, enough air will be forced in to take its place : but this may come from outside or from an adjoining room or house, it must be noted. An open grate fire provides excellent ven- tilation, especially if there be an opening, too, near the ceiling into the grate-chinmey. In the absence of a grate, an opening, in size 3 or 4 by 5 or 6 inches, in the wall of a warmed chimney or even stovepipe, will draw off" a great deal of the impure air of a room and give tolerable ventilation for two or three persons. With a high chimney it affects but little the draught or fire. The opening should be provided with a sliding door : and the hotter the fire or colder the weather the smaller may be the opening. Sometimes enough fresh air will then come in through the walls or cracks about doors and windows. If the walls are tight, with storm window^s, weather strips and every #1 ^32 (JONSIIMPTION crevice tightly chinked, a special opening must be provided ; as by raising a lower window-sash, closing the opening below and allowing air to enter bs'tween the sashes. When the outside air is very cold a ver\' small opening may suffice. In warm weather windows and doors should be kept largely open night and day. The quantity of fresh air which should enter a room or any enwalled air-space for each individual occupant has been estimated by the best authorities at a minimum of 8,000 cubic feet per hour, in health. In sickness, more is needed. With less than this, the air soon becomes manifestly impure : and with 10,000 cubic feet coming in per head per hour the air will not be as pure as that outside. The ( quantity should be limited only by the ability to bring it in without per- ceptible draught and to warm it sufficiently, and the greater it is the better. The larger the room or cubic space for each person, the easier it is to prevent draughts : and it is better to have the air warmed before it enters the room. To measure air precisely an air meter is required. A FORMULA of Montgoliier teaches that, if the tem- perature of outside air be 82^ F. — the freezing point, and that inside ii^s" — a difference of 32° — and if a chimney flue, with its contained " column of air," be 30 feet high, an area of the flue of half a square foot — 72 inches — i.e., a chimney flue of this size (say, 5x14 in.) would withdraw from a room about 12,000 cubic feet of air per hour : and of course the same quantity of fresh air would come in, in some way. The area of an ordinary stovepipe is only about half that, or I ITS NATURE, CAUS^^S AND IMIEVKNTION. 283 36 inches. If tlie outsidi; air be at zero temperature, making a difference of 04° F. ])etween it and the inside air, instead of 32", twice as much air will flow out of and into the room. A fresh air irdet area of one scjuare foot, say by means of a window sash three feet wide being raised four inches, in the clear, will permit the passage or entrance into a room of five cubic feet of air per second of time, or 18,000 cubic feet per hour, if it come in through the window open- ing at the rate of five feet per second : a rate about e(iual to the movement of a person walking 3i miles an hour. This rate would be distinctly perceptible as a draught at the point of entrance, but throughout the room it would not be half that rate : at ordinary temperatures, not usually felt. In the same circum- stances a window two feet wide, raised the same height, would permit the inflow of 12,000 cubic feet of air per hour. These figures indicate but an approxi- mation, in round numbers, of the recjuirements. Flushing living, bed, nursing, school and other rooms at least once a dav in cold weather is a ij^ood practice, however good the usual ventilation. When the room is warm, open all doors and windows : if there be a wind a very few minutes will usually suffice to materially change the air in it. Occupants may move about or w^ithdraw from the room. After the room is closed the fresh air is (piickly warmed by the warm interior of the room. Breathe full and deep. Much has been already written herein on the bad effects of shallow, imperfect breathing. Every person should habitually hold the ;<i8f 234 CONSUMI'TION : body erect, sitting or standing, and take full breaths. Many occupations have a tendency to cause stoop shoulders, which contracts the lungs and lessens the breathing capacity. By a little effort this tendency may be resisted. The stoop is a bad habit, objection- able in all cases, and in some persons may help much to give rise to a predisposition to consumption. Habitually full breathers do not take consumption. The nose is specially designed and constructed to be the only natural air passage to the lungs. If there be any obstruction in it to the free passage of air, as sometimes is the case in children, a physician should be consulted. It is dangerous to breathe habitually through the mouth. Most consumptives and scrofulous persons do so. By effort the habit may be overcome, even if it be largely from abnormal structure through heredity. THE DIETARY : FOODS, COOKERY. Well, properly, nourished persons, even animals, rarely become diseased. No narrow fixed rules of diet can with safety be laid down. Much depends on constitutional requirements and individual and ances- tral habits. The digestion and other functions in each individual case must be consulted. Any change should be made gradually. A little experience and observation is usually sufficient, often essential, in selecting the most suitable diet, quantity required, etc. These principles may be, however, laid down: in all cases the food should be abundantly nutritious (nature is everywhere and in everything abundant), ITS NATURE, CAUSES ANU PHEVENTION. 235 yet plain — unmixed, not compound — pure, and digesti- ble. Rich, compound dishes, however nourishing, usually overtax the digestive and assimilative powers in efforts to extract their nutriment. Good bread, not fresh, of course, of wliole wheat fiour being in most cases best, milk and fruits, for children, and for older persons, some flesh meat and " vegetables " if desira- ble, constitute the best diet. Fried food, new bread, pastry — pies, cake and the like — and highly seasoned and mixed dishes, are neither digestible nor whole- some. Comparatively but little food will sustain life when one is at leisure, idle ; much more being required when at steady hard work, mental or physical : more too in cold weather or a cold climate. Never hurry at meals, nor eat when over-fatigued or worried ; unless it be but a little warm fluid food or a biscuit for refreshment. Starchy foods — potatoes, bread and fruits, should be thoroughly masticated into a soft pulp with saliva. This fluid aids much in the digestion of the starchy parts. To DRINK much at meals is not a good practice : but when from the nature of food or other cause there is a desire for liquids, one may sip them in moderation, when there is no food in the mouth. It is usually best to take the bulk of the fluids when the stomach is empty, as on getting up in the morning or on going to bed. It is, indeed, a good practice to drink a glass or two of water at such times, hot or cold. Many persons do not take enough water for the purposes of complete excretion — purification. Regularity in times of eating is desirable. Any 23G CONSUMPTION : phy.siological function is easier when performed with regularity. Hence tlie facility witli wliich some habits are formed. Tlie NUMBER of meals each day is of less importance than the total quantity eaten. Many meals tempt to overeating. Av^oiD EXCESS OF F(J()D. From long personal and other experience I have been surprised at the small quantity of food which will sustain an adult person in the best of health, especially when not engaged in hard work, and when it is thoroughly digested. The excess is liable not only to ferment in the stomach an<l bowels, and give rise to all sorts and conditions of local disturbances — " indigestion " — but ])robably also to poisonous substances — ptomaines, which readily cir- culate throughout the body and disturb and depress all its functions; while the excretory organs are over- taxed in etiorts to dispose of or cast out the excess. Appetite — natural desire for food — the sensation of HUNGER, should be a safe guide as to the quantity required: but in most cases in the present age the natural appetite is so pampered from early childhood by over-seasoned or sweetened food, that it is not often safe to trust to it alone. The desire to gratify the sense of taste is mistaken for a demand for more food — for actual hunger. A careful distinction nmst be made here between the two desires: that to gratify the gustatory sense, and that to satisfy the needs of the body. Experience, with careful observation, eating slowly of only plain food and watching carefully for the first feeling of satisfaction as distinguished from satiety, will enable anyone to soon learn the quantity of food actually needed by the system. ITS NATURE, CAUSES AND PREVENTION'. 237 ned witli ne habits is of less . Many onal and lie small It person igage<l in ied. The nach and litions of bably also iadilv cir- d depress are over- bxcess. sensation juantity ) age the childhood it is not o gratify for more ion must o gratify needs of )n, eating fully for led from quantity Children often receive injustice from parents, all un^vittingl3^ in being allowed to lay the foundation for future suttering and disease by indulging their unsophisticated appetites with focjds too })leaHing to the taste of the easily tempted little ones, commonly from excess of sugar. The welfare of all ciiildren is nncjuestionably best ))romoted l)y the use solely of the plain foods — bread, milk, fruits in season, fully ripe and sound, usually best raw, or not cooked with sugar. These, moreover, are usually highly relislunl and enjoyed by the little persons with no ac(iuired appetite for other foods. Cookery is most intimately associated with the nourishment of the body ; and bad cookery is respon- sible for much derangement of the body functions. It is impossible for anyone to be properly nourished on badly cooked food. 'I'he art of cooking should be generally and correctly taught, as in the schools or in special institutions. Radical reformers, who would make man again a non-cooking creature, may do good by denouncing the ai-t of cooking in its present form. Raw beef, if pure and sound, is probably better than over, or badly cooked beef- and certainly good ripe seasonable fruits are better raw than when over-cooked in the usual w^ay with sugar, forming the too common preserves and jams of most countries. Tea, coffee, and alcoholic beverages, it need hardly be said, should be indulged in only in strict moderation, if at all, by ever; oody. The intemperate use of alcohol in any form lowers the vitality : and it does not take much imbition of it to practically Wy- 2;i8 (•OXSIJMPTION ccHistitute inti'inperance with this powerful Htiniulant. Many young girls, and mothers, too, use much more strong tea, less frecjuently coffee, than is consistent with healtli or digestion. Many great sufferers from over-indulgence in tea have come to my notice. The watkr and milk supply must .be closely looked to, and spring, well, or other water kept free from any form of conte 'tion. If its purity be doubted it should be boilea. The milk used must be pure and especially from healthy cows. If at all sus- pected, it should be sterilized by heat — a little below the boiling point (or ISO*" F.) will suffice. .li GENERAL BATHING AND THE SKIN. The bath to keep the skin clean and active is an essential of health which is not generally appreciated. The importance of the skin, with its probably two and a quarter millions of s-^^eat glands (Huxley), as a vast emunctory, has beer ided to. The skin has been termed " the most important organ in the human economy" (Baruch). It performs a number of important functions: (1) that of a strong protec- tive, sensitive covering to the inner organs ; (f!) that of touch ; (3) that of excretion — casting out — of car- bonic acid and urea (as it were, aiding the lungs and kidneys) besides other waste solids, with a large amount of water by which, as vapor, in the form of perspiration, it (4), most important of all, regulates the body temperature. Every clothed human being, in order to keep this great defender of the body in a healthy and sufficiently active condition, should take !■' ITS NATUUE, CAl'NES AM) 1M{KVKNTU)N. 239 111 Htiiiiulaiit. ) much more is consistent ifferers from lotice. i .be closely er kept free bs pnrity be sed must be If at all sus- > little below IN. active is an appreciated, robably two uxley), as a le skin has gan in the s a number on^ protec- 18 ; {?.) that 3ut — of car- e lungs and th a large he form of 11, regulates man being, e body in a hould take a daily bath of sonu- sort — a wash ovri the whole body surface with after friction : this not only in warm weather but in cold, when it is most needed. Tf such a practice could be made univ(>rsal, the public health .standard would be innnen.sely increased. Much that would be of int*'rest could In; written on the history of the bath and value of public bathing for public cleardiiiess. The difference between the facilities for, an<l practice of, general bathing amongst the peoples of the East, ancient and modern — Per- sians, Hindoos, Egyptians, Turks — when compared with those of Western Europe and America at the present time, is as remarkable as it is inexplicable. In Russia, whatever the sanitary ilefects, the use of the vapor bath for cleansing the skin, Doctor John Bell informs us (Treatise on Baths), "is general, from the Emperor to 'he poorest serf;" and in all northern Europe " there is no hut so destitute as not to })ossess its vapor bath." In Tokio, Japan, there are, it is said, eight hundred public baths (almost as many as Rome ever could boast of), and the poorest laborer there can have with facility the luxury of a daily thorough skin cleaning. The liberal use of soap and water, it is com- monly said, is a great civilizer. Few persons, if any, will deny that, as Doctor Simon Baruch (Phys. Man- hatt. Gen'l Hosp., N.Y.) words it, in a pamphlet, " A Plea for Public Baths," " Among the agencies which the experience of the human race in all ages has demonstrated to conduce to the preservation of health, personal cleanliness occupies the foj:*emost position. . . . Cleanliness, perfect, absolute cleanli- ness" Without a clean, open-pored, flexible, active f \ I i^^^^j^^ 240 CONSUMPTION J f *m 8*^ " J^~ skin, no one can be clean within; witliout inner (blood and tissue) cleanlineHH no one can be' truly healthy. The eminent Hufeland said, " I repird cleanliness and cultivation of the skin as the chief means for pro- lon^in^ life." How is it in these very countries we regard as the most civilized ? The great body of the people are here commonly characterized, by the compara- tively few who do habitually wash the body surface, usually in cold water only, as the "great unwashed!" While cultivating one special feature of Christian civilization — charity, have; not Christians been guilty of neglecting a common duty which was intended by the great Founder of that civilization should not be neglected — personal cleanliness by more fre(pient washing? By making baptism {(jVimk, Baptisma : hapficAi, to dip in water) the first manifest emblem of Christianity, it could not have been intended that the then connnon practice of bathing amongst Jews, as well as Greeks and Egyptians whose priests bathed two o)* three times a day, should be in any way or degree neglected or superseded by that " charity," now so conspicuous in the provision of almost every want for the masses of the people except facilities for ordinary reasonable personal cleanliness — for keeping clean the living " temple of God " (St. Paul). The value of public bathing has been clearly dem- onstrated, practically, in Germany, where in recent years a system of warm shower or rain b!>ths has been iytroduced into cert^iin schools and bai'racks for washing the puj>ils and soldiers. Amongwc these ITS NATUUK, CAUSES AND PHEVENTION, ^41 |K!r.soiis, HO l>atl)0(l, tlun-e lias been, a.s a consecjuence, n marked iiuproveineiit in health, vigor and intellec- tual power, witli a redueed mortality. The Director of one of th(5se wehools in Weimar reports that, althouj^h at fir.st l)ut few pupils were disposed to take the hath, after two luonths, 75 per cent, of them took it daily, and " tlu; freshnesH and pleasure for study after the bath, the cultivation of a desire for cleanliness an* I the promotion of health, offer such decided results that 1 cannot refi-ain from recom- mending " the syst(!n> to other schools. Certain manufacturers there have provided their employees with facilities for bathing, and the improved health and more efficient service of the en^.ployees give a good return for the outlay incurred. At a health congress a few years ago in Hastings, Kng., Sir Edwin Chad- wick said, " The Cerman army was the lowest death- rated of any in Europe" (5 per 1,000 men: England, H: France, 10; Italy, 11, per 1,000). "One means of this was the factor of washing with tepid water, 'i'hat, he had shown, in England, was the great means of reduction of the children's diseases in the district schools. In Germany half a million soldiers were being washed with tepid water at the cost of about ()d. a hundred, soap included. He expected to be able to display a power of washing children with tepid water at the rate of . . . one ptuniy for a dozen" (8 minutes for each pupil at each jet or bath). "He had long ago shown that washed pigs put on one-fifth more flesh than the unwashed, and more than this was the result wnth children " (Brit. Med. Jr.). 10 P^wtS.] 5 242 CONSUMPTION : Shower baths by sprinkling jets can be provided at less cost than immersion baths, and the cleaning effects are better : each batlier while rubbing his body being under a continuous sprinkle of fresh water. In the New York Juvenile Asylum, 280 are washed per hour, each with fresh tepid water. Until special provision for more general bathing be provided, there is no one who could not at least wash all over the surface of the body every day with the warm hands dipped often in water, just as the face is commonly washed. TV * constitutes an easy, refresh- ing, invigorating bath. An occasional warm water or vapor bath for "opening" — cleaning out, the pores of the skin is necessary, especially for persons who do not perspire freely ; for those exposed to dust a good wash with soap should be taken more than occasionally. The innek bath, to wash out the tissues, is as essential as the surface bath. Said Doctor T. Lauder Brunton, F.R.C.P., etc. (Phys. St. Barth. Hosp.: in Cavendish lect., 1895), " Water is not only useful to wash out our closets and flush our drains ; it has a similar effect in our bodies, and tends to wash away the waste products from the cells of which our organs are composed, to clear out the uric acid, urea and phosphates through our kidneys, . . . and to wash out our liver, especially an organ which suffers much from want of water." For the most part, the improved health resulting from a sojourn at various " springs," he, with other high authorities, contends is from " an abundant supply of water " in the body rather t!ian from any " medicinal " ingredient in the watei-. provided ut e cleaning ig his body water. In vashed per bathing be least wash ly with the 3 the face is isy, refresh- rm water or the pores of ons who do dust a good Dccasionally. issues, is as )r T. Lauder . Hosp.: in ly useful to IS ; it has a wash away 1 our organs urea and and to wash ufFers much le improved " springs," ids is from 3ody rather the water. ITS NATURE, CAUSES AND PREVENTION. 243 SOME OTHER ESSENTIALS. The CLOTHING should be such as to prevent chilliness or a feeling of coldness : but on the other liand, not such as to create sensible perspiration. When out of doors, one in fair health should keep warm rather by exercise than by the clothing : reserv- ing heavy or thick overcoats and mufflers for the coldest days or for driving in. Woollen is probably best to wear next the skin at all seasons. It need not be worn in bed. The garment worn next the skin during the daj should never be worn in bed. The oftener the underclothing is clianged, and either washed or well shaken and exposed to the air and sun, the cleaner, and better the action of, the skin. As to the quantity of clothing necessary, habit and use have, as in everything else, much influence. One may by wearing much, soon seem to require much, or on the other hand, habituate themselves gradually to comparatively little. Of exercise (physical) the great majority of per- sons get enough; many too much: many, particularly women and young children, not enough out of doors. Large numbers of young men do themselves harm by engaging too freely in the more active games. Al- though exercise is highly extolled and reconnnended, probably the benefit of out-door exercise is often much more from the out-door part— purer air and sunlight, than from the exercise in itself. A certain amount is an essential of life : and all the muscles must be brought into daily use or they will lose their actual ilil 244 CONSUMPTION : i! I'y^, ihX% structure and become soft and weak. Then their action — their repeated shortening and swelling out, in producing motion, greatly promotes the circulation of the blood, and also of the lymph. Lymph, it should perhaps be stated here, for non-medical readers, is a thin watery fluid which circulates in very minute delicate vessels, called lymphatics, about as freely as does the blood. It seems to be a sort of auxiliary to the latter in both nutrition and secretion, with an intermediary function between the blood and true tissue structures ; a kind of " go-between." The lymphatic glands exist along the course of these vessels, and are very liable to become the seat of tubercle bacilli. Exercise is therefore a necessary agent in both nutrition and the elimination of waste. It also promotes respiration, digestion and sleep. A good many persons — students, writers, sewing girls — do not get enough active exercise to keep the breathing function up to the health standard — the " breath good," and the muscles fairly firm. The remedy is obvious, and must not be neglected if health and life are valued. Athletism is the other extreme. Overwork, on the other hand, is frequently a strong factor in causing consumption. Some men and many wives and mothers drudge their life away, joylessly, the latter usually at in-door household work, probably baby-nursing, striving to " make ends meet " or per- haps with the unwise object of saving money. Con- sumption is more likely than any other disease to be the consequence of the exhaustion and depression en used by such a life. What physician after a few ITS NATIHE, CAl'SKS AND PMEVENTION. 245 years of practice cannot recall the death From this disease of a mother, caused, remotely but largely, by liousehold drudgery while suckling an infant { Men who overwork do so usually in the open air, and serious consequences follow less fre([uently. Rest more, busy, active wives and mothers : rest. Lie down, and calm and rest the mind, too, two or three hours every day. Let the least important worlc go undone. Sleep checks and moderates, at fixed poiiods, the incessant and perpetual stream of vital consuuiption: said, a hundred years ago, that distinguished philoso- phic physician, Hufeland. From sleep we "obtain the happiness of being daily re -born ;" of "passing every morning into a new and refreshed life." The importance of getting sufficient sleep need not be dwelt upon. Probably no one can do well with less than six hours, or needs. more than eight. The best hypnotic is a judicious combination of a contented, un worried mind, a body free from symptoms of in- digestion, slightly fatigued, and a comfortable bed in a (juiet, well-ventilated room. Sunlight is another essential of health, which is not commonly prized as it should be. A large pro- portion of men and boys get it freely out of doors, but many women, young girls and little children suffer for want of it. Husbands and parents should see that their wives and little (jnes get more out-in- the-sun recreation, and more surdight in-doors by means of uncurtained windows. Avoid excess in everything, we must, if we would preserve even a fair degree of health and vigor. 246 CONSUMPTION : \,m %n I W' Q &> [w- Bw i:^ If ' Intemperance of any kind, soon in some cases, later in others, depresses the vitality of the whole organism, and predisposes to consumption. The excrktory functions must be kept in order. Usually they will not reiiuire more than attention to the general instructions herein. Constipation of the bowels, however, nnist be prevented or removed, as by the coarser foods or mildest laxatives, with regular " habit." The kidney excretion, if not free and clear, may require more water drinking; and the skin, occasional exercise, to cause free perspiration, — or a warm or rather hot bath. All infections should be by all persons, particu- larly chi'-^ren, carefftlly avoided. It may not be too Utopian to hope the time will come when from more perfect public sanitation and personal hygiene, infec- tions will be practically eradicated. Meantime, the infected should be kept isolated. Concluding precepts : make no sudden changes, but gradual changes, in established habits and uses. Never neglect a " cold on the lungs," but if it be not " going ofi'" in a week or so, apply to a physician. In convalescence, or when not verv well, exercise extra care in avoiding infections. Do not marry a con- sumptive, or not until she, or he, is free from marked predisposition. Avoid night vigils; the depressing weed, tobacco ; mental worry or depression ; and endeavor to keep on the peaceful side of all mankind. CHAPTER XIII. SPECIAL INDIVIDUAL PREVENTIVE MEASURES. We have now considered in sufficient detail the general essentials of health, applicable individually to the entire population, for the prevention of disease generally, or of body derangement of any kind, and consequently of the development of a predisposition to consumption. It is safe to say that if the instruc- tions given in the previous chapter were fairly and practically carried out by everybody, few if any such predispositions would ever develop. Lamentably few, however, of those who know the rules of health follow them even fairly well, or not until the discomforts or pains of a deranged or diseased body awaken them to a realization of the fact, that in order to keep fairly healthy it is necessary to be guided in our habits of life, not altogether by our more or less morbid or sophisticated desires or inclinations, but rather by certain reasonable health rules or laws : laws for the most part made known long ago, by inspiration to man by his Creator, through the great law dispenser, Moses, the transgression of which inevitably brings, soon or later, in some form, the punishment — the consequences of " sin." Then, indeed, ill 248 CONSIJMI'TION ill-: till II the pound of cure is sought for. We shall have, therefore, for a long time to come, numerous persons developing a fitting soil for the tubercular seed ; whilo at the present time there are thousands with soil already fitted. Let us next, then, consider some special measures for preventing the development of the disease in persons who possess, in a greater or h^ss degree, either from inheritance or habits of life, the predisposition to it, as already described. In Part I. of this book the nature and importance of respiration was explained, and the manner in which imperfect performance of this function seems to give rise to a predisposition to consumption. It was also explained, how the lungs perform a double function — that of supply (of oxygen) and that of elimination (of waste), or excretion : how they expose to the atmospheric air within them the blood which had just circulated throughout the V)ody, and allow it to get its load of oxygen and discharge its load of carbonic acid and watery and other vapors ; how that when the lung membrane is contracted or thickened and not as active as it should be, sufficient oxygen is not taken into the body, and waste matters are not cast out but accumulate in the blood and tissues ; and that there, eventually, in their decomposition, they probably give rise to certain inorganic substances — food for sapro- phytic, vegetative micro-organisms such as the tubercle bacillus — and also, to some special organic toxic compound (or compounds), by which in some way non-virulent bacilli are transformed into pathogenic or disease germs, which then constitute an essential ITS NA'miE, CAIJSES^AND rilEVENTFON. 249 factor in tlie production of tubercle and causation of consumption. In brief, it seenis highly probable, as it was my endeavor there to demonstrate, that a certain condition of body produced by the decomposition of accumulated waste in th(; blood and tissues consequent upon defective breathing, is also an essential factor, indeed, practically, the immediate exciting cause, of consumption : and that all other causes, excepting the bacillus, are rather secondary or remote, and for the most part only help to produce the defect in respiration. For example : all depressing, debilitating habits, as in respect to diet, exercise (or want of it), etc.; debilitated or deranged conditions, as in rickets and measles ; also, lung adhesions from pleurisy ; and still more directly, dust and other air impurities, more especially those from the breath, all contribute to limit or obstruct the breathing function. There are many bad breathers ; many persons who do not breathe enough air ; who from proportionately small lungs from heredity, or from habitual shallow breathing with originally well-developed lungs, often influenced by occupation, perhaps by close study at school, do not take into the lungs enough air and oxygen, and consequently do not throw otf the waste excremental matter which should be thrown off by the lungs. The system then eventually becomes poisoned by its own tissue refuse, the dead waste of imperfect tissue metabolism, or wear, or the toxic products of the decomposition of this waste. Further- more, full breathing is essential to the free circulation of the blood and lymph, and hence also to complete i fc 250 CONSUMPTION rt^li i'W .4' i. H , nutrition; and so shallow breathing contributes in this way, too, to the general bodily derangement. As Professor Roberts ( Boston) says, " As a man breathes so he lives. To half breathe is to only half live." Now, whether any special bacterial food or trans- forming toxine be produced or not in persons with a defective respiratory function, it is from imperfect breathers that consumption selects its victims ; if not actually in every instance, practically so. These are the persons who provide the " good soil " for the seed ; these are they who take the disease. No physician now undertakes to treat or cure the disease, however early the stage, even in the pretuber- cular condition, without lirst of all making efforts to improve the respiratory function, — to increase the intake of oxygen and consequently output of tissue waste, by at least insisting on the use of the " pure air " or " out-door " remedy, or an out-door life. Usually physicians go still further in this way, and recommend all such patients to breathe deeply and freely of the pure out-door air, and perhaps with some special chest exercises ; or as in some cases, the pneu- matic chamber is employed, or it may be, the inhalation of oxygen is recommended. Defective respiration is never alone, it need hardly be said, never the only cause of the predisposition. It never works up the special body condition — the fit soil, by itself. Helping it on are usually impure air, improper food, depressing habits and other assistants. The remedy in such cases is simple, chiefly to improve the breathing function. It is comparatively ITS NATURE. CAUSES ANB PREVEXTION. •i.")! easy to habitually increase the amount of air breathed, as already stated, whether the defect be hereditary or ac(|uired. Especially is it easy in youn^ persons. Even in persons advanced in years, and those in the early stages of consumption, the breath- ing capacity may be considerably augmented. While improving res[)iration, other conjoined causes nuist be removed. Pure air must be breathe* 1, night and day; the food must be made as suitable as possible ; the skin especially must be attended to, and so on. Usually there is no difficulty in any person recog- nizing the imperfect breather after attention is once drawn to him, or to her, by the failure in general health or vigor ; or in case of hereditary defect, by the general delicate or puny constitution, as ex- plained in a previous chapter. i GENERAL RESPIRATORY EXERCISE. Persons predisposed to consumption particularly require general exercise, because of the increase in the circulation of both blood and lymph which it causes, and the consequent elimination of waste from the body. But exercise demands force, and force, digested food; and the strongly predisposed are there- fore often not able to take much exercise. Hence the necessity and value in the worst cases and in the earlier stages of the tubercular state of passive exer- cises — massage and " Swedish movements ' — given by another person, without effort by the affected person. It is necessary then for the predisposed to take exer- cise only proportionate to the constitutional ability, >i 2r,2 roNsrMrriox : hihI without cxliaiiHtinij : to which |)oint i\\v cxcM-nisc should never ho curricMl, nt)r even to j^reat, on\y to sliffljt, I'atij^ue. This is important. It i.s safer to eir on tlie side of too little. Thos<; exercises which tend more particularly to expand the chest and lung's an? to be reconnnended. Erect posture of body, sitting, standing,' and walking, with the slioulders and head set well back, as in the following figures, 1 and 3 (from Check ley), ■11 llM Fig. 2. Fig. 3. Fig. 4. is particularly desirable. A stoop is ver}'^ commonly a precursor, indeed a cause, of contracted lungs, and must be promptly and completely counteracted. By taking the correct posture whenever it can be thought of, most persons will sooi ' hen strongly impressed with the import 1' it, acquire a habit of keeping the body ereci ^t first it ay be tiresome, but by use the musck. become stronger and the upright the <'X<n'oiH(> •eat, only to safer to en* whiclj tend 1(1 lungH are ^andinfj and t well back, n Check ley), Fig. 4. y commonly d lungs, and eracted. By n be thought y impressed t of keeping 5ome, but by the upright ITS NATUKE, CAUSES AND PUEVENTlOiN. 253 habit unconsciously sustained. Children disposed to stoop should be encourage«l to keep erect by being frequently reminded of it. Occasionally shoulder straps or supports are necessary ; ' but I have very rarely found it so. When use<l they should be left off when the upright habit is ac(|uired. Walking increases largely the respiratory function. Running produces a moi'e marked effect; and walking up hill a still more. Hence tennis, golf, crickt.'t and even baseball are useful exercises. Hoxingand (juoits are also good. Football and lacrosse are liable to be too violent. Rowing, if it do not excite too nuich the heart's action, is goo<l; paddling still better; so with the more prosaic wood sawing or chop[)ing. In the latter it is better to have the log or stick raised up, as on a special " saw horse." WHien bicycles are so constructed that the rider is required to sit up erect, bicycling may be indulged in. Horseback ri<l- ing has been extolled perhaps more than anything as a mild exercise for consunqitives. It is Ixist to sit firmly on the saddle with the body and arms in full play with the trotting horse. When one walks the arms should swing freely. Any exercise which greatly increases the heart's action, as to "palpita- tion," should be avoided. In all cases avoid dust as much as possible. SPECIAL LUNG EXERCISES. A variety of exercises or so-called lung gymnastics have been recommended by different physicians for increasing the lung surface and function. Some of 254 CONSUMPTION h I It ^-t-i |i:i these require certain appliances, as dumb-bells, chest weights, etc. ; others are simple or '" free." The use of most appliances requires the expenditure of more force than do free exercises. The object is to increase the respiratory capacity — tue size of the chest and lungs — first of all, and with the least expenditure of force. Free exercises are therefore usually best for non-vigorous persons. To simply increase the breathing capacity, in cases with no lung disease, it has been my practice during the last quarter of a century to recommend the fol- lowing free exercise, which has proved quii.e satisfac- tory : In pure air, out-doors when possible, standing in a correct position, slowly carry the hands from the sides to meet above the head, well back, and at the name tiiae draw in air slowly until the whole trunk is fully distended ; then while slowly bringing the hands down again let the air out slowly until the trunk is compressed as much as possible. Breathe two or three times in tlie ordinary way and repeat the act. This do five to ten times ; and three or four times a day or oftener go through a like exercise. After a little practice endeavor in the acts to dis- tend the chest as much as possible without straining ettbrt ; hence slowly. Should slight dizziness occur at any time, as it may at first with very full disten- sion, it will soon pass away. In beginning, some young persons experience difficulty, usually from haste in the attempts. A little time and patience will give success, in this as well as in the more complicated vigor^us ^^xercises to be presently Joscribed, M^ ITS NATURE, CAUSES AND PREVEXTIOX. 255 Besides increasing the chest capacity, it is desirable to strengthen the chest muscles that tlie increase maybe permanent. For this, the six formulas below (chiefly from Denison, as cited) answer every purpose. The forms should be practised in the order given : the first, milder ones for a time, and then the next, and so on, reaching the more vigorous perhaps only after months of practice. Each act, as directed in each form, is to be repeated three or four to ten times in succession on each occasion, — few times at first, more after practice, and one, two or three times a day. And one should always go through them deliberately, not hurriedly. The latter more severe ones are not indis- pensable, remember, to gooil health ; but when ratlier a pleasure than a cause of weai-iness or discomfort, they usually give greater vigor and resisting power. The time, place and dress for the exercises are of importance. An hour or two before or after a meal is the best time. They shouM always bi taken out in the pure open air, if at all practicable ; if not, in an open shed or large, cool, liglit, airy room. Tlie clothing must all be so louse as to permit the freest possible movements. This is an indispensable condition Cor- sets must of course be left oft', (,'specially while exer- cising, and be worn very loose at all otiier times. Persons of strongly marked predisposition, and es- pecially after any blood spitting, must be carefid in the beginning in even the mildest form, that already described : r.nd of course, in such cases, under the guidance of a physician. All the forms are perfectly sife at any stage when gradually, carefully an<l lirrr If r ' I'i ! liP 256 CONSUMPTION moderately practise*!, only mildly at first, with but few repetitions. Besides the special forms, or to begin with, it m well to practise striking the arms out forward, as in boxing, and sideways, too, with a degree of vigor pro- portioned to the strength, and for a very short or a longer time, always breathing deeply. In all cases or exercises start with, and pause in, the correct posture or attitude of body. 1. Stretch the arms out, from the side, to the front, horizontal, then slowly draw the elbows back, close to and past the sides, as far as possible, and take a long deep breath at the same time, and repeat. 2. Slowly raise the arms to front horizontal while taking a deep inspiration ; then hold the breath while the largest possible circle is made with each hand, both at the same time, upward and backward, above the head, and around to the sides again. 3. While settling down on the toes, as represented in Fig. 5, make a forced expiration; then while rit 'ng slowly to full height take a full inspiration, and at the same time move the hands in a circle, downward, backward and upward, somewhat as in swinnning, with the arms stiff. 4. While extending arms directly forward to hori- zontal take a deep breath ; then without moving the face or feet, move right arm and chest around toward left as far as possible, keep left knee stiff, bend right one and couch the floor with fingers, expiring while returning to correct standing attitude : next, take another deep breath while raisiiig arms again to front ill' ITS NATURE, CAUSES AND PREVENTION. 257 , with but with, it in NAvd, as in vigor pro- short or a I muse in, the 50 the front, ack, close to take a long zontal while breath while ;h hand, both il, above the represented while rit 'ng ition, and at J, downward, swinuning, r&vd to hori- moving the Iround toward F, bend right cpiring while next, take Lgain to front horizontal, and then turn left arm and chest to the right, bending left knee while touching the floor. 5. Extend the arms to side horizontal and walk thus into a corner of a room, as in Fig. 6, and while there take from three to ten full inspirations: by I'. f Fig. 5. Fig. 6. practice from day to day gradually get a little farther ftnd fart si- into the corner. 6. Place two chairs about twenty inches apart, and with the body straight and stiff', rest on the toes and hands, — Fig. 7 : settle down between the chairs and take a few deep inspirations and then raise the body to the height of the extended arms. 17 258 CONSUMPl'IOX : r ii PI' 111 ! ■ I'i: li if li'iii I! P }! Ill Remember the instruc.tions given in the three or four paragraphs immediately preceding these for- mulas: commencing gradually with the first and simplest exercises, etc. HOW TO KEEP OUT OF DOORS. It has been stated that the benefits of an out-door life are more from the pure air and sunlight than from exercise. It is commonly believed that in cold weather one cannot be out much without exercising Fig. 7. a good deal or working, in order to keep warm, or unless well wrapped in a carriage or sleigh. This is a serious mistake. By putting on sufficient clothing one may sit or lie down out-doors when the ther- mometer is below the freezing point. I have per- suaded patients to sit outside most of the day, and with a camp-cot or lounge, to occasionally lie down, with heavy under-flannels and two cr three coats on, in freezing, December weather, witii great benefit. Women may contrive to dress equally warm. On any approach to a feeling of coolness, and before chilli- wii ITS NATURE, CAUSES AND PUEVEXT1(>N. •259 e three or these for- 3 first and m out-door nlight than that in cohl t exercising; p:: ^^ eep warm, or iigh. This is jient clothing len the ther- 1 have per- the day, and ally lie down, tree coats on, reat benefit, warm. On before chilli- ness, a little walking about or arm-swinging is neces- sary. When one is so circumstanced as to be able to drive, of course it is pleasanter ; but there is no reason why one may not keep as warm sitting on a comfort- able chair or lying «[uietly on a lounge out in the sun- shine in severe weather, as in an easy open carriage or sleigh moving about, except it be in the diversion of the mind by the little change of scene in driving. One can be " bundled up " just as well on the cliair or lounge ; and read nmch better. In this way invalids may safely remain out nmch more than seems possible to many persons. The feet and hands slumld be well protected. The chief point is to put on abundance of clothing on every part of the body. Wraps and (juilts may be used. Always exercise care that the breathing be not in any way or degree impeded by the clothing ; and keep up deep breathing. OCCUPATION CONSIDERED. Choice of occupation for the prevention of consump- tion is a subject perhaps next in importance to that of provision for breathing abundance of pure air ; for it closely concerns or bears upon the faciHty or possi- bility of a perfect respiratory function. All persons at all predisposed to this disease sliould therefore give it special consideration. Besi<les too c(mstant confine- ment in-doors, there are two ways in paiticular in which occupation may even give rise to the predis- position : namely, first, by necessitating more or less strongly certain body positions which cramj) the chest and prevent habitual full and free expansion of ™* ' i" i jmn 260 CONSUMKriON the lun^s ; and second, by giving rise to excess of (lust in the atmosphere. Pei-sons working in a dusty atmosphere, too, naturally avoid deep breathing. The influence of occupation upon health and espe- cially as predisposing to consumption has been long recognized. Over a third of a century ago, Doctor (Jreenhovv, a practical sanitarian, in Kngland, drew attention to the enormous mortality from this disease in England and Wales, chiefly from the eflects of dusty occupations. The death rate was particularly high amongst potters, grinders, fllemakers, printers, masons, w ol and cotton manufacturers and others working in dust; also amongst tailors, dry-goods clerks, groct./s, bakers, carpenters and dressmakers. In 1860, the medical officer of the Privy Council reported that. " In proportion as the male and female populations are severally attracted to in-door branches of industry, in such proportion, other things being equal, their respective death rates by lung disease (phthisis) is increased." Since that time a gi'eat reduction in the mortality has been effected, as by wet grinding and free ventilation. • Much yet remains to be done, however, on this continent, as well as elsewhere. A practical illustration of the effiicts of occupation on the consumptive has been recorded by Doctor Herman Weber (Croonian lect., 1885). Although it has been many times published, it w^ill be well to quote it here as briefly as possible. A teacher and his wife both died of consumption under Doctor Weber's care. They had had seven children, the second one of whom had died young of tuberculosis ITS NATURE, CAUSES AND PREVENTION. 261 of the brain membranes. At the mother's doai/h, four boys, of twelve, nine, seven and two years of age, and two girls, of five and one, respectively, were living and fairly healthy, except the youngest boy who had rickets. Of eleven cousins of these children, nine (lied of consumption before the twenty-eighth year of their life. The prospects of the six orphans looked gloomy. They were sent to the country — a moun- tainous district in Silesia, and brought up with nmch care under Doctor Weber's instructions. The eldest, up to the age of twenty-three, so long as he lived mostly out of doors, with probably hill climbing, was well and strong. " He then became a hard student, working night and day, having his meals in his rooms, and taking very little exercise. In eighteen months afterwar<ls he died of rapid consumption. The second son was a farmer, and remained healthy until his twenty-nintli year. He then became tired of the monotony of country life and went into a mer- cantile house, where he was engaged for many hours each day in an office. He worked hard at his books in his own room during the evenings. After two years he had repeated iia3morrhages, and in two years more he died of tuberculosis." The third son became a cavalry soldier, lived judiciously and remained liGalthy and strong. The youngest son, who had been rachitic, was a healthy farmer in Manitoba a year or two ago ; and his younger sister, a healthy girl, was keeping house for him. The elder daughter married a country clergyman and r^»nained quite healthy. The history of this family, l^octor Weber remarks, 202 CONSI'MI'TION : hvi'i ri: "shows thatl)y favorahle cii'cuiiiHtuncas.even a strongly marked family tendency may be neutralized. . . , It further teaches the serious lesson, that if the strin- gent rules of health are neglected, even after the constitution has l)ecome satisfactorily developed, the disease may suddenly show itself and run a rapid course," to a fatal termination. In selecting an occupation for one predispostjd to consumption, many points must be considered and weighed. All such as are sedentary and requiring nnich time in-doors should be avoided. It is not suffi- cient to be out for a few hours each day. Any occu- pation which gives rise to dust, or which requires an unusually high temperature, as in overheated rooms, or a stooping posture, is highly objectionable. The occupation should not be laborious ; though as much general activity as the constitutional strength will well bear is desirable." "Travelling" (commercial) on account of the irregularities of such a life is not usually suitable. Then, in order that the occupation may be agreeable and of interest, so that success in it is likely to follow, a selection in this behalf must be made. All this narrows down the choice. Again, life in a city, chiefly from the air being less pure, is less healthful thnn in the country, or small country town. The city, too, provides a smaller proportion of out-door occupations. Agricultuue in some one of its forms, with some precautions to be named, is probably of all occupations on the whole the most salubrious ; although a sea- faring life may be in some cases preferable. Stock or ITS NATrilK, (AI'SKS AND I'KEVENTION. 2n:i poultry raising, fruit j^rowin^ or <^ar«l»'iiiii^ may easily be uuule a sutliciently light or easy einploy- irient. Certain objectionable features in ordinary farm life require to be removed in order to obtain the full advantages of the work. For example, during the colder season in northern latitudes there is often too much in-door life ; and worst of all, in unventi- lated, overheated rooms. The bedrooms, too, are usually small and unventilated. Some of the work gives a strong inclination to a stooping posture, and sometimes there is a dusty atmosphere. Farm-houses and their surroundings are commonly in a more insanitary condition than city houses. These objec- tionable features may be in a large measure or entirely, and easily, removed. Carpenter work and brick or stone laying out of doors should not be much more unhealthy than work on a farm. Of the learned puofessions, it appears that the average life of clergymen is the longest, and that of law the next. From the medical knowledge of physicians they should live the longest, even subject as they are to exposures and irregularities. In country practice, especially if not made too labor- ious, it should be, as indeed it not infrequently is, pro- motive of health and longevity. The time of study required for a profession is an objection ; yet with due care this may be overcome by persons not of a strongly phthisical family history. A few persons study medicine chiefly in the interests of their own health — for ^he medical knowledge it necessitates. Surveying and engineering are healthy occupations. w- 5 264 (.'ONSI'MITION C,r IR i"^ 'Sf Fou WOMEN, suitable healthy eiiiployinents are still more difficult to select. There is no reason why many more women should not engage in the lighter forms of gardening and flower growing, and in poultry raising. A few have done so with success. A large majority are practically forced to household work with the care of young children. Such work is, however, sufficiently active and varied, and need not be made over laborious. If all rooms were well ventilated and lighted and kept at a proper tempera- ture — if the air within were kept as pure as it might easily enough be, if the "out-doors" could be much more freely brought in, housework would be one of the most healthy of employments. Tiiis want of pure air prevails to an equal, sometimes greater, extent in almost all other occupations for females. In teaching, in office employment, in shops, dressmaking, millinery, factory work, there is a like want of pure air. Women, as suggested in the case of men, should enter protests against the impure air and dust they are now in many cases practically forced to breathe. Husbands should more deeply consider the necessity for pure air for their wives engaged in housework. DIGESTIVE AND NUTRIENT FOODS. Next to a supply of pure air and good respiratory action is nutrition through the stomach. Hence the diet must be specially considered. Doctor W. H. Porter goes so far as to say (at N.Y. Acad, of Med.) that " V&r the most could be done in eradicating tuberculosis by feeding properly from infancy up." ITS NATl'HE, CAl'SKS AND IMIEVENTION. 265 The digestion in many caHCs wlien the predisposi- tion is marked is |M)or, insufficient for good nutrition. Out-door exercise will improve it, often sufficiently. Horseback riding, jogging, is usually particularly good in these cases. Exercises which bring into action the muscles of the trunk are also good. It may be necessary to resort to massage. It is very desirable to keep the bowels regular. Simple nutritious food, well cooked, must in all cases be provided. The best authorities would givt;, as a rule, only a moderate allowance of animal food. I have seen a decided phthisical predisposition in young persons practically eradicated on a d ^t of milk, bread and fruits, largely of fruits, espc illy apples. By most authorities Kuch a diet is recom- mended as best for young children. Why not for older peraons ? Von Ziemssen says, " The ' grape cure ' and the ' whey cure ' conjoined with uiountain air," — doubtless any pure invigorating air, " are ex- cellent." If such food be excellent for the cure, surely it would be also good in removing the predisposi- tion. In the case of some persons, from a diet largely of fruit, enough nourishment seemingly cannot be extracted. The addition of plenty of milk and bread usually makes it sufficiently complete. Special foods are not often required except in the more strongly predisposed — in the pretubercular con- dition — a part of the subject which will be explained further on. The supply of good rich milk when it can be digested and assimilated, or of the lean of meat, beef being best, r.iay be increased if it seem ■I I n ill f' ^ '4 206 CONSHMrriON desirable, as in some cjuseH it will. OecaHiunally minced or HCi'aped hief or beef juice i-s necesHary ; or, it may be, predif^ested food — peptonoid.s or beef meal. Fats seem to be often indicated, but little beinj^ habitually taken in a numl)er of these cases : hence the use of cod liver oil ; a fat, from its nature or .source, u.sually easily assimilated. Sometimes cream is better, more acceptable to the stomach. PUEVENTING " COLDS " : THE COLD BATH. A *' cold on the lungs " frequently gives rise to a condition favorable to the development of consump- tion. Persons of a consumptive family being more than usually liable to such colds, it is most desirable that every precaution l)e exercised to prevent the colds. With this, a little of the " hardening " process is good, to lessen the susceptibility to sudden changes of temperature. Of all measures for this purpose, that of keeping the skin active and vigorous by the daily cool or cold bath is best. The practice of hab- itual bathing has already been highly commended for everybody, and all persons disposed to take a cold easily are particularly urged to adopt it, and in as cold a form as each individual constitution will well bear ; on account of the tonic effects. Personal ex- perience, since early life, and observation of its good effects in the many cases in which I have enjoined it on patients in a practice of over a quarter of a cen- tury, warrant me in strongly recommending it. The simplest form of cold bath, and which in nearly all cases is quite sufficient for susceptible non- ITS MATI'KE, CVrsES A\l> IMtEVFN'TloN. 207 ,er of a cen- vigort)U« pei-Hons, is that ol' a wash tixer the whole body vvitli the warm hands ivpiNitodly wet in oold water juHt as inost persons wash tlie face. The bather may stand on ai sipiaie of oilelotli with a piece of carpet under tl»e feet. Ahnost any person, even the least vi^roi-ous, can take this bath, and in two or three minutes, with but a pint or two of water. A spon<^e or cloth may be used, but the hands being warmer, — an<l, if ne(;essary, they may be first well warmed — feel less uncomfortable to the beginner. The room for most persons, particularly at first, shoultl be comfortably warm ; and the quick wash should be followed by suthcient brisk rubbing with a dry, ratlier coarse towel to secure good after- reaction — a warm, smooth, glossy skin with a feeling of comfort and invigoration. A soft towel, as abs(.)rb- ing better the water from the skin, may be used for the drying, and a coarser one for the after friction. On commencing the practice, or if reaction be not good — warmth and comfort do not at once follow, a part only of the body, as the chest, may be exposed and washed at the one time and another part later, directly after or otherwise. At first, too, the water may be tepid, and gradually used colder and colder from time to time. Delicate persons who never could take a full bath by immersion, even slowly, in water only a few degrees colder than the skin, without much gasping from the mild shock of immersion, and after discomfort from want of good reaction, have been, to my personal knowledge, able to take this hand bath without discomfort, indeed with ^,'' 4 1:1 1^ ( i '■I ■ r i } II 2fi8 CONSUMPTION : relVoHliiu^ invinonitiou iiinl tin? Ix'st of after re8ultH, ofip<!ciuIIy in oxomption from coIiIh. And it has HurpriHcd nio to find how readily .sonu; non-vigorou.s pLTHons become able to tak(? tlie l)ath in quite a cold, alniOHt I'roHty room. Keeble persons on bef^inninjj may recpiire hel)) in order to take; even a partial bath (juickly enough : the (piick action of washing and <lryi!ij^ producinj^ undue » xcitenH^nt. No rash- ness must be attempted ; cold is a powi-rful remedy. A little time and care arc^ suffieiiMit to secun^ success. Som<i more vij^orous persons are more benefited l)y a sliovver or rain bath, as bein^, when borne, still more invi^oratinjr. Do not be and>itious to use water too cold, — rather comfortably cold, with the IwMly warm. The preferable time for the bath is on rising wai ni from the bed in the morninj^. It may be taken Just before goinj^ to bed, or at any time three or four hours after, and an hour before, a meal, Ziemssen remarks on this subject, — ** I cannot con- clude this chapter on prophylaxis without referrin<( to hydrothera|)y, which occuj)ies a very important position both for the prevention and cure of tiibercu- losis. Winternitz, to whom principally we owe scientific hydrotherapy, has published his experience relating to its use in this disease in a brief essay, entitled 'Studies of the Pathology and Hydrotherapy of Puhnonary Phthisis,' which 1 strongly recommend. My experience of the ' hardening ' method, where there is an hereditary or accpiired disposition, agrees fully with his. Water at suitable temperature is the best, simplest, most available agent for strengthening ITS NATDKfc:, (Al'SES AM) IMtKVKNTION'. 20f) er rcHultH, 1(1 it luis i-vigorouH ite a cold, hcjijinninj^ a partial F waHliinj^ No rash- il rcincily. r(^ HuecoHH. Htod by a still iiion^ water too ly vvariu. fiinj^ wai in taken juHt je or four aiinot con- ; roferrin*; important if tiibercu- \vo owe experience rief essay, Irotherapy Bconimend. od, where ion, agrees ture is the jngthening and ' hardening ' a weak luxly or one disposed to catarrhs and colds. Kven a simple rubbing down of the entire l)ody with a large; moist cloth, after getting up in the morning, ac(Mistoms the skin to sudden cool- ing off. The practice drills the vaso-motor nerv(\s of the' periplwral arteries to prompt r(\«iction. It acts on the respiratory, circulatory and digestive systems. At Hrst, water of about HV}' F. is to be used, an<l the cloth should bi; well wrung out. On each succeeding morning the temperature of the water may be reduced un<'-eighth of a degree." In weak constitutions where app(!tite and assimi- lation are poor, Ziemssen recomnn'nds that common salt be added to the water in considerabh- (piantity. Should a mon; thorou<rh tnratment be desiralile, Ziemssen continues, " the. patient may bo sent to a water cure." (or hydrothei'ap<uitic) establishment: "necessary in persons deficient in will power." "This simple [>rocedure overcomes si^nsitiveness to changes of temperature, wind and dampness, and rende*rs excessive clothing unnecessary. It ov»'rcomes con- stant slight j)ersj)ii-ation, nasal and bronchial catarrhs, rheumatic disposition, etc., ant I gives to the body frc^shness and elasticity." For a healthy, vigorous skin, as already stated, its absolute cleardinesH is indispensable, and, for most per- sons, a more thorouirh wash should be taken weeklv or from time to titne. Soap is but rarely necessary, except at the beginning or for persons engaged in a dirty occupation. Soft water with friction is u i 'ly sufficient. For persons with thick, coarse .skin, or i 'P V'' 1 ' > .; m;: 270 (.'ONSl'MPTION almost any per.H(;n, an occasional hot-water or vapor bath for cleans ig and opening the pores is desirable; and usually it i invigorating to pour a little cool or cold water over the whole body immediately there- after. And a weekly hot foot bath with cold water poured over the feet immediately after, is good for keeping thf* skin of the feet active and less susceptible to cold and dampness. The clothing in its relation to the skin — its changes, airing, etc., has been already sufficiently treated (page 243) ; except that non- vigorous persons usually ; quire a little extra clothing; not so much on the body or chest as on the extremities, even to the hands and feet. Wear enough on the feet especially to keep them always comfortwlily warm. In cold w^eather one pair of stockings is not usually enough. Rubber should be worn only on the bottom of the feet — the soles. Draughts, even very moderate currents of air, strike too much terror into a large number of persons. Strong cold draughts are not good. From this the fear some persons entertain of mild currents has doubtless arisen. For the most part, any after aches or pains, or the little "cold" somewhere which many experience after exposure to a mild draught, arise from so care- fully or constantly avoiding them, and from absolute fear. No one will deny that cold, chilling draughts are bad, and are to be avoided. But any person may in a little time become so accustomed to mild draughts as to suffer no inconvenience from them; and any little discomfort at the beginning would Ix' much more than compcTisated for by their invigorating effects and ITS NATUllE, CAUSES AND miiVENTION. 271 the usual greater purity of the air, i\s when coiiiiuj^ from outside into an uiiveiitilated or crow*!*'.? room. One can often prevent tlie cold effects or chill by wraps or a screen. A coat collar turncMl up will often suffi- ciently protect the neck and face : and the hif(h head- hoard of a bed divert the current. Be not, therefore, too much afraid of mild, pleasant currents of pure air. This, too, is advice j^iven from personal experience and close observation. A FEW WORDS TO PARENTS. Parents with a predisposition toconsumptioi. should above all others be watchful of their children from birth. Even before the birth, the niother should be particularly careful in res])ect to her own health, and to that of hei" unljorn offsprin<^. She shouM breathe freely of pure out-door air; subsist on i)lain nutritious food, in judicious moderation, yet in plenty: keej) the skin healthy by the bath and proper clothing; exercise or work mo<lerately. newr to <ner-fati^ue ; secure a full amount of rest and sleep: an<l never indulge to excess in ant/ of the ])h'aHures of life. The child, from birth, slumM be es|)ecially cared for, and as Sollesgive.i it, "on the lines of nature." It nni.st not be overcared for or cijddled, but rather cautiously hardened b}' cool bathin<ij: and provide<l with abun- dance of fresh air, sunlight and .suitable food and clothing. Above all, the icspiratory function should, receive attention as eai'ly in life as possil)le. So soon as the infant can walk well, it may be (>n('ourag«'<l to run and romp and to climb, as up a stair or hill. As it grows up there imist be i>o slackening in the care. t ill jvhl 4 272 CONSUMPTION Encourage it to run and romp as much as possible with other healthy children out-doors in the sunshine. Boys usually get enough of this, but girls often, in- deed commonly, do not. Encourage them, too, to run and romp and climb. Encourage all the little ones to sit, stand, and walk perfectly erect, with head and shoulders well set back. This adds much to their good appearance as well as to their vigor. Encourage them to use their lungs freely ; not to expand and develop them disproportionately, although hardly anything need be feared in this way, but to build up a full chest with good active lungs and heart. Special light gymnastics may be needed to aid in the development of the chest. Usually, however, free romping and climbing with habitual full breathing suffices. Encourage children early to breathe only through the nose by keeping the lips closed ; taking care that the nostrils are not obstructed. Their food must be always simple and digestible, yet nutritious; and their rooms — nursery and sleeping — well ven- tilated and lighted. The skin all through life requires special attention. It should be kept clean, soft and active by the bath and friction. When it is coarse and harsh, an occasional anointing with cod liver oil, followed the next day by a warm water and soap bath, will be benetieial, during early life especially. The school, as relates to its locality, structure and surroundings — tt) drainage, ventilation, cleanliness, sunlight, etc., should be looked after by the parents, and not left altogether to the authorities. Children of this class should never be sent to any school not ITS NATURE, CAUSES AND PUEVENTION. 278 possible sunshine, often, in- )o, to run le ones to head and . to their Encourage pand and h hardly ) build up b. Special d in the ever, free breathing jathe only d; taking heir food lutritious; well ven- fe requires , soft and is coarse cod liver and soap especially. cture and leanliness, e parents, Children chool not perfect in respect to these condition j; and perhaps above all, parents should see that tlv school is not in any measure overcrowded. Some boys, and girls too, acquire at school or elsewhere most rlepressing secret sexual habits, and this possibility should cause parents to exercise the most watchful care in tliis behalf. The choice of occupation nnist })e also well considered. As there is no doubt that infants may be born with the actual seeds of consumption — the tubercle bacillus or its spores — in their bodies, especially if the mother be in a marked degree tuberculous, then still more specific preventive measures may be demanded. !f the infant a[)pear to be puny or the nutrient or excretory functions not well performed, a physician should be consulted, an.l proper efforts made to correct these conditions and build up a more vigorous organism. Special nutrient food — oils, malt extracts, phosphates, etc. — may be required. Some of the imtrient or excretory organs may recjuire stimulating into action, or be in an irrital)le condition and require sedative treatment. Only a phyi^ician can decide these points, and prescribe the re(|uired remedies. Watch closely for any early, more marked symptoms of the disease, such as contiiuied failure in appetite for food and loss in weight: always remembering that most persons, even children, lose in weight and take less food in very warm weather. Early treatment, on the first manifestation of symptoms of the disease, is in some strongly predis- posed persons, the onh/ treatment that is likely to Hucceasfully combat its development and progress, 18 274 CONSUMPTION' : MARRYING AND GIVING IN MARRIAGE. No two perHonH, each haviiijr a family tendency to consumption, should ever unite in wedlock. When both parents inherit a temlency to any defect, that defect is usually intensified in the children. Noi- would it be safe or wise in such a case, of double heredity, to rely on time and hygienic measures to remove or destroy tht; predisposition, and marry later. Yet two such persons ilo sometimes so marry, and to the almost certain perpetuation of a fatal disease. That very affection — that love — which usually attracts to the marriage tie, should of itsell restrain any man or woman in such circumstances froni bringing upon the object of love the almost certain consequences of a diseased progeny. Full knowledge of the consequences, with a little refiection, should prevent such unions. Legislation in this behalf has been suggested. Very little practical good, however, would come from legal restriction. Parents and friends may sometimes do something towards preventing the consummation of unions of this kind. Usuallv all possible influence is brought to V)ear against misalli- ance in respect to wealth and social position. If like influence were exercised on behalf of purity and vigor of bodily constitution, an aristocracy of health might hii looked for. Everyone thinking of marrying should considei- most seriously not only his or her own ph^'^sical con- dition and family history in respect to disease, but also the health and health history of the person of tbe opposite sex who purposes entering into the ITS XATCRE, CAUSES AND PREVENTION. 27; ideiicy t<» :. When feet, that :en. Nor of double 3asures tt) 1(1 many so man-y, of a fatal ^•e — wV»icb M of itw'lt nances from oat certain knowled^*' ion, should behalf has d, however, and friendis venting tin* Usually all ust misalli- )n. If like V and vigor ealth might Id consider hysical con- disease, but \e person oi" into the union ; this not alone for the sake of the two con- tracting persons, but more especially for that of their probable offspring. When the predisposition is only on one side — in only one of tlie contracting persons, and especially if on the other there be good health and vigor with a good history, the case is quite different. Burt says, " A man with a tubercular family history, and possi- bly a phthisical diathesis, should be made to under- stand that he is a potential source of much sorrow and misery if he selects for a wife a woman with a similar record and constitution. Contrariwise, an intermarriage with a family free from all such pre- dispositions will do not a little to curb that downward tendency. A child with good blood for a legacy, even from one parent, has every reason to expect immunity from the disease, if he is reared intelligently." It should be borne in mind that sometimes by waiting a year or two the predisposition may be largely ov^er- come by good living. Indeed in all cases of a pre- disposition, even on one side, there should be delay in marriage, with this view. AVOIDING AND PREVENTING INFECTION. We have seen that consumption is in a measure infectious : that in certain circumstances, as when one person for a lengtli of time nui'ses another advanced in the disease, the infection — the bacilli, may be communicated from the diseased body to the non-infected one, yet one which has become in a measure predisposed. Anyone, then, having in any degree a predisposition, either inherited or acquired, I 276 CONSUMPTION : r iw' ; )iM >i.! 1 should avoid close intercourse with cases of the disease, as in the same household or family. The best and safest way to avoid " takin^j " any infection is by not providing the soil — by keeping the body in health and vigor. When the soil is favorable, or there is a predisposition, the only safe way is to avoid sources of infection, especially close intercourse with the infected. When a member of a household has the disease, with cough and expectoration, such person should be in a measure isolated : provided with a well-lighted, airy room, or, better, two such rooms, so that he or she need not mingle with the family. Intelligent con- sumptives with proper feelings would prefer and desire this, rather than communicate their affliction to friends. 'J'he isolation need not be very strict : this especially if the case be an exceptional one in the family and the predisposition not marked ; and with due care in the disinfection of all infected excreta. Separate rooms to live in — to sit in usually and to sleep in — are desirable. Other members of the family need not unkindly shun the afflicted one. The first essential in preventing the spread of in- fectious particles is absolute cleanliness : cleanliness as perfect as can possibly be secured in everything and every way : — cleanliness or purity of the air within doors, of the body, of the bed and body clothing, of every corner and crack, of not only the sick-room but the whole dwelling. And this means, in the main, cleanliness from dust, including sputa, particles of which may soon become dust, as may almost every form of dirt. In the dust of rooms, it will be remembered, tubercle bacilli have beep found. ITS NATURE, f'ArSES AND PREVENTION. 277 Bacilli form a part of the " elomonts of the dust." For clean, non-dusty air in rooms there must be thorough ventiUition. In sickness of tliis nature free vefitihition is domarnled more than at any otlier time. Yet in practice we commonly find it (juite the con- trary : and this has cost an incalculable numV>er of human lives. The unchanged air favors the predis- [)osition and also the spread of the infection. Doctor Rjinsome has shown that in the back-to-back houses in the lar^e cities in En<(land, in which it is impossible to provide good ventilation, consumption is " ex- cessively frecjuent ;" and chiefly it is believed from tliis cause — want of ventilation. It is probable that in all those individual cases of consumption believed to have originated in infection, the brief history of which has been given in Part I., there was a want in this respect. And it is probable, too, that by perfect ventilation alone nearly all such cases would be pre- vented, — infection would hardly occur at all. Squire remarks, " It is a significant fact that nearly all the cases of probable direct infection from a phthisical patient take place in small and ill-ventilated houses, and are almost unknown in the airy houses of the well-to-do." Remember, sunlight, too, is essential. The free flow into the rooms by night as well as by day of pure outer air will do the consumptive vastly more good than harm, provi«led he be kept a little to one side of any perceptible draught and clothed sufficiently. Patients in hospitals on the continent of Europe are now placed, well covered in bed, near a widely open window, aside from draught, in cold wea- ther, night and day. In the New York Medical Jour- 27S CONSI'MPTION : iiul (July 27, '95) we now read, — " M. Roeliurd leinarkH (Union Med.) that tlie mode of treatment instituted l>y Doctor Detweiler at tlie Falkenstein Institute was not at first taken sufficiently in earnest. The idea of consumptives living in the open air at a low tempera- ture and allowing currents of air to pass through their bedrooms at nijjht was looked upon jis eccentric, l)ut the advantat^es of this treatment have come to be recognized. The pure, cold air quiets the cough, lowers the fever, arrests the night-sweats, restores the appetite, and retards the course of the disease," The first principle of ventilation, remember, is to withdraw the impure air from the room, as by a grate fire or warm flue, in ortler to make room for the pure outer air to entor. A layer of muslin, or cotton batting, in a wire screen, may l>e fastened across or over the open window, for preventing a too rapid inflow, oi* strong draught, especially when there is much wind or the weather is cold. Floor cracks and corners are notable collectors and sources of dust and infections. A good moderate- priced *' sanitary " flooring material is much needed. The cracks in ordinary floors may be greatly improved by being carefully filled with paper pulp and then oiled and varnished. Rooms or wards for the sick are now made without angular corners, in walls and ceilings, a cove taking the place of the angle, and without cornice and base, or any place for dust. The less furnishings of any kind in sick-rooms the better, because the easier kept clean. Carpets, window or other curtains, and most upholstered furniture are particularly objectionable dust-holders. If they ITS NATURE, CAl'SES AND PREVENTION. •270 arc tolt'iutojl at all, thcv shouM Ih' taken out wecklv or ot'tenor, sliakcn well aiul exposed for a time to huh 1111(1 air. All heddiuii- and l)odv clothintr should be so treated dailv if it ean l>e done. A few mi's on a well polislied riooi- ^ive a nnieh better, because a cleaner, iiioie aj)propriate or artistic, appearanct^ than a carpet. Dry dustinj^ as usually ])ractise<l stilus up tlie particles and is of very little benefit. All dustei-s should be slightly dani))ened In' a sprinklinjjof water, or a weak .solution of carbolic acid: or, as ])leasanter. of a diluted tincture of an es.sential oil — cinnamon or winter^reen. They need not be mad" dam}) enovi<;[h to ap])reciably dampen furniture. While in use tliey should be frequently shaken outside; but not, as often is done, directly in front of an open window whil<? a current of air cari'ies the dust directly back into the room. They mav sometimes be shaken out well down below the window on the ietiward side. Kverythinjr in the room on which it is po.ssible for dust to settle niu.st be p)ne ovei*. and the oftener the better, if properly <lone and without " nuiking a dust." THE SPFTTLE AND OTHER EXCRETIONS. The expectoration oi* spittle of consumptives, con- tainincf as it usually does a fijreat number of germs, must be carefully disposed of. From it, as we have seen, active virulent inf<>!ction may directly arise : particles of it soon drying and becoming a part of the dust. It may so surround bacilli as to preserve their virulency for a long time. Within doors the disposal of this source of infection is not difficult. Every particle of matter coughed up Am ill ivra M W .iil.t iiHj § ''till ^ w' :il w' 4 'li i • llH 1 ^ hit Wi' -1 IMAGE EVALUATION TEST TARGET (MT-?) V ^ // %r {/ L<? A i/ji 1.0 I.I «- ilia mil «^ lllitt 46 3 I 40 IM 2.2 M 1.8 1.25 1.4 1.6 ^ 6" — ► Photographic Sciences Corporation 23 WEST MAIN STREET WEBSTER, NY. 14580 (716) 872-4503 1 ' 280 coNsuMrrio>^ '.^^.. should be carefully received from the mouth in ii vessel containing a disinfecting solution, or into bits of rag or soft tougli paper which sliould then be put into such solution. The cleanest way when the expectoration is not too copious is to wipe each sputum carefully and cleanly from the lips by ra^*- or paper, so that no particle can fly off from the mass and escape and dry ; as particles often do when out' spits into a vessel. This, however, may be in a measure prevented by holding the vessel close up to the lips when it is used. Even then it is usually desiiuble to afterwards wipe the lips. Inexpensive paper cups may now be obtained for receiving sputa, which after use are destroyed with their contents. Probably the best way to finally dispose of sputa is by burning carefully in a large fire, as that of a furnace : but never in a small fire, as in a cookinu; or other stove. If thoroughly disinfected it may go to the sewer through tlie closet, or be buried in earth. The vessels, if not burned or buried, should be well scalded. As a disinfectant for receiving the sputa, corrosive sublimate is commonly recommended, — one part to 500 of water, or stronger. Carbolic acid, — one part to twenty of hot water — is an effectual germicide ; and, if desired, its odor may be largely overcome by adding oil of cloves first dissolved in alcohol. These disinfectants are highly poisonous, and should be very plainly and strikingly so marked. When out of doors, the consumptive should always carry rags or paper for receiving the spittle, to be afterward destroyed, and should never by an\' chance spit on a floor, sidewalk or other i-oadw^ay, ITS NATURE, CAUSES AND PUEVENTION. 2.S1 yard or public place whatever. Firtsks for spittiiio- in which may be cai'ried in the pocket are now madr and in use. Pocket handkerchiefs for this purpose are decidedly objectionable. Washing them is not only disj>;ustin^' Imt dan*(erous, from possible inocula- tion. Professor Graham mentions a case whicli came under his observation, in whicli infection was conmiunicated in this way. The body surface must be kept strictly clean. Spores, if not parent bacilli, are said to be thrown oft* by the skin. The wliole body surface sliould be well washed daily with water, and the cooler this can be borne without much discomfort the bettei*. All other excreta as well as that from the lun^s and skin should be also carefully disinfected. The moutli and nostrils shoidd be often cleansed with hot water, to which some pleasant <leodorant may be added. After the death of a ])erson fronj tuberculosis, all apartments which had been occupied by the deceased, at least, must be carefullv disinfected beibre beinu" again occupied. Ever^'thing movable shouhl be taken fi'om the rooms and disinfected by heat, as in boilinof water, or by, such solutions as already mentioned, and by free and long exposure to air and sunlight. The flooi^s, walls, ceilings, and every corner and crack should then be thoroughlv washed with hot water, soap and carbolic acid, or the corrosive sublimate solu- tion, and be long opened up to air and light. PRETUBERCULAR PREVENTIVE MEASURES. Persons strongly predisposed to consumption, in the pretubercular con<lition, with loss of vigor and 282 CONSUMITION ■•'M I! >, I? ol it* perhaps of appetite for food and of body woijfyht, while exercising more than usual caution in respect to infection, should also be more particular in carrying;' out instructions for increasing the respiratory capacity l)y lung gymnastics and habitual full breathing, as already pointed out. This, with an out-door life, moderate exercise and sufficient rest, judicious cloth- ing and care of the skin by means of the bath, suit- able, nutritious food, and a well-ventilated bedroom, is in many cases sufficient to restore health. In yet more extreme eases, more special nutrient foods besides oil, cream, beef preparations and predigested foods, — such as malt extracts, ale or porter, with phosphates, etc., may be required, and a physician must be con- sulted, A change of locality, too, may be desirable. If space permitted, I should be pleased to give here, as profitable exanijiles, the history of a few cases of the pretubereular condition, strongly marked — in persons thought to be " in a decline,'' in which I have observed entire recovery by means of increased lung capacity with attention to the skin, good ordinary nutritious food, out-door life, and a well- ventilated bedroom, in a salubrious locality : without any other remedy. Many such cases have come under my observation in practice. In a number of them, too, the patient had previously liv.^d much out of doors, but with defective respiration. Such cases would well illustrate the power of simple, natural remedies, while explaining the cause of the body condition : showing, too, that it is sometimes enough to remove causes of illness in order to effect a cure. CHAPTER XIY. STATE AND MUNICIPAL PREVENTIVE MEASURES. Some measures for the prevention of consumption, as well as of other diseases, cannot be carried out by individuals alone, and require united effort, as through municipal and even state authorities. The most important of these, as stated, and which promise the best results, are such as prevent or remove the individual predisposition to the disease. And most can be done in this direction by the education of the masses of the people rather than by coercive measures. The better education of the masses concerning tlie ordinary requirements of health is indispensable to success in the prevention of any disease, certainly not less so in behalf of this most destructive of all diseases: education — warnings, directions, encouragements — in respect to personal habits and surroundings — to breathing, to foul damp air and sunlight, to cooking, eating, bathing, sexual relations, and to dirt in its various forms: education through the schools; by means of public lectures; and by free distribution of pamph- lets. In country towns, villages and farm dwellings, as well as in large cities, sleeping apartments, for example, commonly, and often living rooms, especially 284 CONSUMPTION : ^ti;. M 1 those of women and children, are sueJi as should not be tolerated in this age — small, dark, dank and unventilated, with an atmosphere laden with poison from the breath and tobacco smoke. The human skin, — square miles of it, is so clogged from want of the bath and from habits of clothing that the lungs and kidneys are injured in efforts to do the extra work thrown upon them by the inactive skin. For the credit of humanity, as well as for pecuniary public gain and general welfare, there should be a decided improvement in health regulations and habits every- where. It should not be forgotten that an entire connnunity may be seriously injured by the evil influences — the carelessness, iilthiness, diseased con- dition, of a very few persons, or even of one ; and that want of knowledge of the sum of the evil cdnse- (juences of living unhygienic lives is the principal cause of the bad surroundings, conditions and habits almost everywhere met with. There should be more united effort to help those who are not able to help themselves to an improved hygiene, and to compel those to do so who are not willing. The united efforts now being put forth in some states and cities for preventing the dissemination of the seeds of consumption in the spittle of infected persons, by a certain amount of oversight of those suffering from the disease and of their dwellings, with instructions as to what they should do to prevent the communication of the disease to others, will doubtless be beneficial — bear good fruit. It is most desirable, however, that health authorities as well as individuals ITS NATURE, CAUSES AND PREVENTION. 285 IH ^shoul(l not , dank and 1 with poison Tlio human from want ol' lat the lungs lo the extra /e skin. For juniary public be a decided habits every- bliat an entire I by the evil diseased con- one ; and that le evil cc^se- the principal ns and habits lould be more )t able to help ,nd to compel "orth in some semination of e of infected iicrht of those wellings, with jO prevent the will doubtless nost desirable, as individuals should strike first, and in a mo* > distinct or marked way, at the predisposing causes ; treat these as of the first importance : strike for preventing the develop- ment of cases requiring oversight. This would be the true prevention. Public measures for this purpose are possible and practicable. Health authorities should never do that which tends to prevent or lessen individual effort — to prevent per- sons from using means for individual or family protection, but on the other hand, should encourage self-effort for self-preservation. Individuals must rely largely upon themselves, be a fortress unto themselves — keep their own body fortified. We must not expect the police to prevent our house being robbed if we harbor a robber in the household. LINES OF LEGISLATION. Legislative enactments and municipal by-laws as now commonly in force and intended for the promo- tion of the public health generally, tend also to pre- vent consumption. Enactments and by-laws more particularly aiming to prevent this disease should be on such lines as indicated by the following heads : (1) For the Better Instruction of the People in Special Preventive Measures ; (2) Prevention of Air Fouling in every form ; (3) Establishment of Free Public Baths; (4) Drainage of Retentive Damp Soils; (5) Inspection of Butchers' Meat and Dairy Products ; (6) Inspection and Oversight of Schools ; (7) Oversight in Certain Cases of the Disease ; (8) Hygiene of Domestic Animals. 286 CONSUMPTION ■J • . i i i! r !i i li Unsuitable marriages is a subject which medical writers have suggested as one upon which there might well be some legislation. It has been stated that in Brazil, on account of the increase of " scrof- uhi, " there some years ago, a law was enacted pro- viding for the medical examination of persons about to marry, and for preventing the marriage of those pronounced unfit. Laws of this kind would have little terror for those " in love," or who believed themselves to be. Education and the influence of parents and friends must yet remain the basis for preventing the marriage of consumptives. Already in most countries there are certain legis- lative provisions applying to some of the above- named subjects (2, 4 and 5) — air fouling in factories, lodgings, etc., and drainage and food inspection. These provisions, however, are for the most part or generally not enforced as they should be ; and although of some benefit, are probably in all cases far from being efficient. PREVENTIVE EDUCATION. The public schools provide an excellent means for instructing, theoretically and practically, the coming generation, and in a measure the present one, in ways for preventing consumption, if but taken advantage of. Almost everything is taught except health pre- cepts. It would be much better to teach " language " relating to a good physical constitution than a foreign language ; and better a health drill than even a. fire drill. Pupils are not taught even the first essential 1 : ITS NATURE, CAUSES AND PREVENTION. 287 lich medical which there 1 been stated se of " scrof- enacted pro- jersons about iaare of those would have A^ho believed influence of the basis for 3S. certain legis- f the above- (T in factories, »d inspection, most part or uld be ; and in all cases mt means for ■f, the coming t one, in ways :en advantage -pt health pre- " language " han a foreign ,n even a lire first essential of right living — how to breathe ; and thosij who do breathe properly do so in a large measure in spite of school influences tending to impede the respiratory function, such as foul air and a stooping posture. Pamphlets with special instructions for preventing disease and promoting the general health, of both individuals and communities, might well be freely dis- tributed, as well as the pamphlets on prevention of special diseases which health boards commonly dis- tribute. And if such paniphlets were made more attractive in both appearance and style of composition, they would not be so likely to be " pigeon-holed " as some have been, it is said, on good authority. It must be remembered that although many good seeds are sown, comparatively few of any sort fall on good ground and bear fruit. Two to four page leaflets, clean, bright looking, large open type, on " How to Breathe," "How to Let in the Out-doors," "How Not to Cook," " What Not to Do for Health," and such like special, striking subjects, scattered freely about would be read probably by ten or more persons to every one who would even " look through " the heavier, dull brochures on the more repulsive diseases. Popular lectures, particularly on the value of health, by a fairly good speaker would attract fair audiences and be largely reported in the local papers. Local medical officers in England have done some- thing in this way — given such lectures. Why should it not be made a part of the duty of such officers on this continent to give courses of lectures, or " health talks," in various localities in their jurisdiction ' I 288 CONSUMPTION By such means fi^enerally and judiciously carried out, the great majority of the people, now so ignorant on this subject, would learn that good vigorous healtli is worth making an effort to preserve or obtain, and also, how to prevent disease, especially consumption. STRICTER MEASURES: BETTER INSPECTIONS. Stricter legal measures, or stricter enforcement of present measures, should be brought to bear on pnj- prietors of all places where persons, whether only two or three or many, are employed at work — factories, shops, rooms, and also of tenements and lodging houses and hotels — for preventing every form of aii* fouling : from the breath, as in overcrowding with want of ventilation ; from imperfect drainage and sewerage ; from excess of dust in any form ; and from infections. Every employer should be comi^elled to make such provision as would prevent any employed person, while actually engaged in his employ, from being injured in any measure by foul air, as well as by machinery, or accident ; and ever}^ landlord should be under like compulsion in respect to every person for whom he provides lodgings, whether in tenement house, hotel or lodging house. Compensation for damages sustained by an employee from impure air, for which his employer is responsible, it seems possible, might be recoverable at law even now ; and this subject is well worthy of the serious consideration of employers. In a number of instances already the tenant has recovered from the laridlord, through the courts, compensation for loss through sickness caused by an insanitary house, ITS NATURE, CAUSES AND PREVENTION. 289 isly carried so ignorant jrous healtli obtain, and Huniption. 2T10NS. orcement oi' bear on pr(j- lier only two k — factories, and lodgin*;- 1 form of air owding with irainage and •m ; and fron\ )e compelled irevent any laged in his [sure by foul t ; and every in in respect es lodgings, ing house, ned by an employer is icoverable at ortliy of the la number of red from the ion for loss house, Food inspection as now attempted, especially in I'espect to meat and milk, is little more than make- believe : as in th(! case of factory inspection, it is com- monly done very perfunctorily. In sonie cases the inspector, often the market constable, probably does " the best lie knomx how" to do. Meat unfit for food is sold everywhere : and while watering milk, a com- paiatively harmless offence, is in a measure prevented, diseased dairy cows and foul stables, vastly more harmful than watered milk, exist on everv hand. SUB-SOIL DRAINAGE. Thorough drainage of the heavy damp sub-soils on which cities and towns are often built would probably be a batter investment — yield larger returns for the outlay, in improved health and vigoi* of the popula- tion and the exemption from consumption and other diseases, than is obtained by even the agriculturist by the drainage of farm lands. Statistics have proved, it will be remembered, that consumption is more fatal on damp than on dry soils. Sewerago, it may be noted, is in no sense drainaij:e of the soil. The sewage of a city may be well carried away by house drains and sewers, and yet the sub-soil remain damp. Tile drainage, with tiles thickly set, is what retentive soils need. There should be some means for prevent- ing the erection of habitations on damp soils. MEAT AND MILK REGULATIONS. For preventing the sale, all too common, of tuber- cular and other diseased meat, public slaughter-houses 19 ii i^ 290 CONSUMPTION : is:. i iii ! iii Hhould bo provided in vvhicli all aiiiiiuils intondisd for food hIiouUI bo killed luvl eut up. Hero all the aniinala .should be examined by a competent inspector both before and after .slau^rhter. It is well known that consumption is less prevalent anion^jjst the Jews than other people, and this is properly attributed to the care they bestow in the selection of meat. This matter is one of serious importance. 'I'he Editor of the British Medical Journal, in a leading article (June 15, '89), writes, " The subject has a most important bearing on public health. It is one that must be taken in hand by sanitary legislators, and the sooner it is tackled thoroughly and on the broadest po.ssiblc basis the sooner sliall we obtain a cleaner bill of health under the heading ' Tuberculosis.' " There has been considerable agitation for public abattoirs on this continent, but little has yet been done in this way. It is now generally conceded that, when an animal becomes tubercular in any organ, both the meat and milk are unfit for food, although the flesh and udder may not be locally diseased. It was so decided in a strongly contested case in Scotland a few years ago after the evidence of the highest authorities in Great Britain liad been heard. Milk supply regulations are really of greater im- portance than those applying to meat, because milk is more commonly used in an uncooked state, is in many cases the sole food of young children, and dairy cows are more commonly tubercular than other bovines. Yet all regulations affecting it are inefficient and lax. To look after the cows — their health, food, ITS NATUKE, CAUSES AND I'KEVENTIOX. 291 drinking water and hoiiHiii<ij — Ih by I'jir t.lio iiion! iin- portaut })art of inHpection. A j^ood iiiodol for nnnii- ('ipalities to adopt is the milk supply systcin in the city of (/()penlia;^en, probably the most complete to be found. The regulations are j^iven in tiie Canada Health Journal of December, 1.S91. The Royal Commission (Ct. Brit.) aj)p()int(Ml five years ajjo to encjuire i'lto the (juestion of tubei-culous food have recently repoi-ted ; in ell'ect, that, — in an api)reciable j)art of the tuberculosis in man the infec- tion comes from food, chieH\ !Vom bovines ; tubercu- lous milk and (hiiry products a] ; (!Xce})tionally active when fed to animals ; and (contraiy ff^ the decision in the Scottish case) a jijioat deal A the non-tuber- culous Jienh of tuberculous anii' ;ds may be eaten if care be exercised in remo\ in^ all diseased parts and orpins, and in cooking the flesh. PUBLIC BATHING CONVENIENCES. Enough has been written elsewhere herein on the value of universal or public bathing. As Doctor Simon Baruch (as before cited) says, " It requires no argu- ment to prove that every consideration of law, pro- priety and sanitation demands that our city authorities take immediate steps to secure to our laboring popu- lation near their dwellings, and in the school buildings, station-houses, etc., the means of cleanliness and re- freshment, health preservation and moral improve- ment, which the public bath is more capable of fur- nishing than cny other more costly investments, and to sustain all benevolent societies who are strivincj in the same direction." Mat ' ^ coNsiMrrioN Unin l»M(l»Mor (i'|>i«l ov not (onrold \v<»trr iirr hy I'm* tlu» lost I'nrm Tor |)ul>li(' iiHc : tlw inoHt circrdml loi* clojiniiiif i\\o liody Mini most atti'tU'tivc Ini- iiiomI |m>|' sons, for wiutiM' nnd sumnu'r use. Tlicy should 1k» in tho (M'utros of (!><» most populous loo.'diticH. The New- York StMl(^ Ii(»ifiNlMttjr<' liMs just I'cccMttIv rimct.«M| a law lu.ikini:' it ujMudntorv lor citit's witli 5(),()()() of n popul.'itiou or ov«M- to ('stahlisli IVoc puhlic hnths, and also/ providiuii" for n^ore ctliricnt action in this lu'liall' l»v the sniallor oitii's. This is a loadinLi" niovcnnMit which should he followed hy all legislatures. -^ S»H()OL VVVW. MAXA<iKMKNT. If every }>iipil on tlie eoniineneenient of school attiMi<lance w»>r(» e\an\iiied hy a physician, or if ex- auunaiions weii* n»ade monthly of all new pupils, ami every one wantiuii' in full hreathino- capacity, or with a chest j^irth helow the full avera^^i', or perhaps not above it. and ev(*rvt>ne with a stoop or round shoulders, wen^ placed for a sut1ici»>nt lenoth ^f time under special treatment for chest development, the number of oases of oonsiunption wouhl soon be nnu'h reduced. Other pliysical ilefects, too. could be nMuedied at the same time. Such ]>upils, and there are many, could W treated in classes, usnallv bv the teacher, under medical ovei*sii>ht. Fuller details than have been j:::iven elsewhere of the various special exercises rv- quirod cannot be entered into in this treatise. A system of tins kiiid, etHcientlv carried out, and with a stronjj im]>ression made on the mind of the ]>upils as they j^row up. as to the value of a <jood chest ITS NATI'MK. CAI'SFS AND IMIFA'KVTION. 'im l\'rtiml lor • mosi ]>«*>• houM Ih* ill 'V\w Nt>Nv r imuu'UmI a no.ooo «)!* M ' baths, and tl\is hohall' ; movoMUMit '(>S. it nl" S('1U)<)1 in, or it' t'x- c ]m]>ilH, au»l oity, or with porha])S not. \d slunildors. tiinc \nul»M- the number lU'b iv«Uu*o«l. unliotl at the nuiny, couUl lachor. under |i have been oxercises re- Litise. Iried out, and Inind of th*' a iTooil chest ami lull breathing, won l«l piobably do more to |»r«'Vfiit ('onHuni|ition than any other inraiiM tlnit could l»; ado|)t(Ml. Iti this way th(« wry youths prcdiMposcMl to the disease — marked out as it wrw I'or it, thousands of them, from whom, only, or almost only. couMumption eventually di'aws it,s double tithe, would be i-eached and rendered pr/ietieally imuuine. OI'I'ICIAI- MANACJKMKNT OK <'AHKS. Instead of eon»)»ulsory notilieation, rejrJHtration, an<I even isolation, which has been proj)osed as a measure for the .sup|)ressi()n of consumption, and which woidd doubtless create opposition and concealment of cases, it. would bo probably wi.ser f<»i' health a,tithoi'iti<'s to adopt the simpler, less extreme plan of leaving the (juestion of notification lar^^'ely or wholly in the hands of the nuMlical attendant in individual cases. 'I'Ik; authorities mi;jjht re(|uest all physicians to^^ive notice of such cases comin<r under theii* observation as in their jud^^ment re(piired oversi^lit and a.ssistance in carryiu}^ out measures foi- ])reventin;^ the spn-ad of tlu; disease; to cases in which neither jiatietits nor friends, from want of means, were able of themselves to can-v out such measures. This would limit notifi- cation to those to whom tlu^ ai<l of pu})lic ofTicials would be not only acceptable, but desir<'d. The; public assistance ^iven wouM more than compensate for tlie semi-publicitj . This appears to be about as much as tlie public are prepared to fully sanction ; indeed about all that is nMjuired, in this line of action. Supplies of printed instructions shoidd be ^iven 294 CONSUMPTION it rrq by the health authorities to all phyisicians for putting in the hands of consumptive patients of all classes or of the family or friends. Formulas for such instruc- tion may be easily made up from what has been stated herein : Chapter xill, preventing infection, etc. HYGIENE OF DOMESTIC ANIMALS. This is a subject so directly associated with milk and meat inspection that it is desirable to touch upon it here. Were due attention given to the hygienic care of animals, they would be kept practically free from disease, and the inspection of these foods would be a comparatively simple and easy matter. The following remarks (extracts from a pamphlet on the subject by the author) may impress upon the reader the desirability of having more special attention given by dairymen and others to the health of the animals, and is all that can be given herein : " Flem- ing says (Vet. Sci.), ' A rational and well-founded system of hygiene, by fortifying the body [of animals] and preserving the different organs in health, is the most certain safeguard against the development of disease,' As iii the case of man, so in that of animals, pure fresh air is lirst in importance. Grognier asserts that horses and horned cattle suffer more than man or carnivorous animals when kept in a bad atmos- phere, and he has described a 'stable fever' in animals in France, analogous to the now past ' hospital fever ' or ' prison fever ' of man, from breathing the foul prebreathed air of stables. " Tlie worst sort of foul air to which domestic ITS XATrRE, CAUSES AND PREVENTION. 295 ['or putting I classes or ch instruc- been stated , etc. with milk touch upon 18 hygienic 3tically free [oods would atter. The )hlet on the a the reader il attention ealth of the n : " Flem- ell-founded [of animals] alth, is the elopment of of animals, nier asserts than man bad atmos- ' in animals ipital fever ' ig the foul !h domestic animals are exposed, and which is most common, is (1) that which has been breathed, and rebreathed over and over, again and again, in close unventihxted stables, and (2) that from manure piles in and near stables and yards. Fleming (juotes an author as saying that ' stables should smell no more of the animal than the dwelling room does of the man.' Parkes says, ' A horse or cow ought to have from 10,000 to 20,000 cubic feet of fresh air per hour. It ought to be practically in the open air. . . . Animals properly fed will thrive better in a well- ventilated place at a low temperature than in a warmer place ill-ventilated.' Besides the value of pure air from a strictly health point of view, reports have been pul)lished of experiments which prove that) cows yield more and better milk when kept in clean, well-ventilated, than in close, foul stables. Cattle do better on the whole in large open sheds with abund- ance of straw than with the more modern practice of ' stabling.' Large sliding doors might be provided which could V)e used for closing the open side of the sheds during the hours of a cold storm from that direction. Cows often require more exercise, prob- ably a good gallop daily. It might lessen the quan- tity of milk given, but would improve their respiration, health arid vigor." It would be well if heads of families would by careful inquiry and even personal inspection see that the cows which furnish the milk supply of the family were suitaV)ly housed in well-ventilated, well- lighted, clean, dry apartments and receive only good f7— f """■■III 296 CONSUMPTION hi 'I ii^ pure food, pure water and sufficient out-door exer- cise. Such personal looking after by directly inter- ested persons would soon improve the milk supply. SANATORIA OR HOSPITALS FOR CONSUMPTIVES. These are amongst the most useful means for the practical prevention of this disease by the State. As a large proportion of consumptives are of the labor- ing or poorer classes, who are often not able to pro- vide for themselves the means of proper treatment, it is contended that the State should provide institutions of this kind. To do so would doubtless be a wise expenditure of public money. In England it is believed that the hospitals for consumptives there ♦ have contributed in a large measure to the decline in the mortality from this disease during recent years. While the hospitals serve to isolate cases and prevent new ones arising through infection, they also prolong life and so reduce the annual mortality. Many cases, too, are practically cured, chiefly by means of the greatly improved conditions of life in which patients are placed as compared with their previous conditions. In the general hospital, consumptives are not only liable to infect other persons, but they are themselves under great disadvantages, in many and obvious ways. When, therefore, it is possible to avoid it, the}'' should not resort to, or be sent to one. Sanatoria — a name which to many persons is yet less Unattractive than the term hospitals, although these institutions are not nearly so unattractive now as they were a few decades ago — should provide for ITS NATURE, CAUSKS AND PREVENTION. 297 door exer- ictly inter- : supply. IPTIVES. ms for the State. As ' the labor- ible to pro- reatment, it institutions 3 be a wise rland it is )tives there le decline in ecent years, ind prevent dso prolong Many cases, ans of the ich patients conditions. ,re not only themselves )vious ways. they should rsons is yet ~[s, although [•active now [provide for at least two, and better three, classes of cases, — classitied according to the stage of tlie disease. For persons in the early stage a separate building should be provided. If they are treated in one with advanced cases, not only would there be greater risk from reinfection, but the mental effect from prox- imity to the more seriously diseased, sometimes dying patients, would be decidedly depressing. A second building should be providecl for persons in the later stages, with yet hope of recovery : and a third for incurables, requiring isolation in the public interest. For the first class, and in the main for the second, only apartments would be required in which to sleep, eat, receive baths, massage and other treatment, as the patients should live mostly in the open air — lying, sitting, walking, driving, riding, playing at games, skating, tol>ogganing, coasting, as most suit- able. It need hardly be stated that such sanatoria should be in the most select localities, constructed on the most approved mo lern principles, as to ventila- tion, sunlight, dryness, etc., and be undei* the constant supervision of the best medical skill. There are man\' cases in the early stages of the disease which need not remain long in a sanatorium. After being, there, placed in a fair way for recovery, with proper instructions and injunctions as to their future course, — after being taught how to live — they could leave and engage in some suitable employment. Or, if a farm were connected with each sanatorium, such patients could be employed on it with profit to both themselves and the institution. 1^1 i " CHAPTER XV. i w I i ' ®f U^ CLIMATE AND PREVENTION. The somewhat extended remarks on climate in the following pages need no apology. The subject is a very important one : change of climate is a remedy fre(juently resorted to, both as a preventive and cura- tive, for consumptives. Yet the eff'ects of climate or of acclimatization on the human functions are not yet well understood. WHAT IS CLIMATE ? Of climate (Greek, H\if.i(V, a slope, — toward the poles or sun), Parkes says, it is not easy to give a definition. " Tlie effect of climate on the human body is the sum of the influences which are connected either with the solar agencies, the soil, the air, or the water of a place, and as these influences are in the highest degree complex, it is not at present possible to trace out their eftects with any certainty. . . . Probably we do not know sufficiently the physiological conditions of the body under ditterent circumstances." (A. E. Parkes, M.D., F.R.S., Prof. Mil. Hyg., Lond. Eng. Man. Pract. Hyg., sixth ed. Vol. ll.) According to Humboldt, " The term climate, taken in its most general sense, indicates all the changes in the atmosphere " as to temperature, humidity, purity, ITS XATTTRE, CAUSES AND PREVEXTION. 209 movement (in winds), variation in the barometrical pressure, etc., which " sensibly affect the organs " and influence " the feeHngs and mental condition of man " Professor Sir Wm. H. Kingston, M.D., D.C.L., etc., in his " Climate of Canada" (Montreal: Dawson Bros.), says, the various conditions influencing climate may be " reduced to two : distance from the equator and height above the level of the sea." " Heat is the con- trolling condition ; " but " the atmosphere modifies all the effects of the sun's rays." And, "It would seem as if this branch of medicine must ever remain to some extent conjectural." Briefly, climate is the condition of the atmosphere in which we live: which we must breathe. This atmos- phere, however, is incessantly changing, by reason of the many and various influences above indicated : — of the sun ; of the seasons and special fixed aspect of the earth's surface toward the sun ; of geological and geographical conditions ; of other or adjoining coun- tries or localities and of the ocean ; and of influences of a more local character, — soil, vegetation, subterra- nean water, etc. So delicate and intricate are some of the atmospheric or climatic changes that no way or method has yet been devised for detecting or explain- ing them : the human body when in health may not : although when rendered supersensitive by derange- ment or disease it may perceive them by their effects. As Doctor Ferrier has remarked, " Nature as if in ridicule of the attempt to unmask her, has reconciled contradictions and realized improbabilities with a mysterious versatility, w^hich inspires the true philoso- 300 CONSrMPTION : m':.: \m ^:,"''K--,- it plier with diffideiiet.', and roduces the systematic to despair." While on some parts of the earth the atmosphere is such that man cannot long survive in it, and in others he cannot live long in health and comfort, in most parts, with reasonable care, he can live to the most advanced age. As ali'eady has been intimated, usually the cjuestion of life and health is more in his controllable habits of life than in the climate. The climate is often blamed when man's habits — of diet, of clothing, of housing — are chiefly at fault. Yet there are but very few places of which it can be truly said: " So sweet the air, so moderate the clime, None sickly lives, or dies before his time." THE ATMOSPHERE AND THE BODY FUNCTIONS. Some of the direct effects upon the human body of the atmosphere surrounding it — tliat is, effects of climatic conditions, are generally well known. Such are thi' depression caused by a damp, heavy atmosphere, act- ing chiefly on, and checking, the function of the skin : and, on the other hand, the exhilaration produced by clear, dry, " ozonous " air ; the characteristics of race, etc. There are certain more specific eftects, too, of much importance. Stimulation, for example, is the first effect of heat. This is followed by reaction and depression, even to collapse. Heat relaxes ; while its absence, cold, in a measure, gives tone, — we might say firmness, stiffness. This has led to contrivances for cooling the air in hot climates or seasons. ITS NATURE, CAUSES AND PREVENTION. 301 ^tt'iiuitic to itniospher(^ it, and ii> comfort, in live to tht' I intimated, more in his imate. The —of diet, of . Yet there e truly said: IJCTIONS. n body of the ,s of cUmatic uch are thi' ^sphere, act- of the skin: produced by sties of race, tects, too, of inple, is the reaction ami les ; while its ve might say rivances for The wanner the atmosphere tlie less oxygen it con- tains, bulk for bulk, and the more tlie respiratory function is reduced ; and usually tlie more active is the skin. According to Parkes, x\. Katray, M D. (Surg. R.X.: Procet'd, R. Soc, Lond.), made observations on tlie weight and lieight of forty -eight naval cadets, figed from fourteen and a half to seventeen years, during four successive elianges of climate during a voyage. The results show that in the tropics they increased in heiglit more rapidly tlian in cold climates, Init that they lost weight very considerably, and in spite of their rapid growth, Ratray concludes that " the heat impaired the strengtli." Parkes adds, " His figures seem conclusive on these points, and show the bene- ficial influence of cold on youtlis belonging to races long resident in temperate climates." Cold air, wliile it contains, in a given portion, more oxygen than warm, also necessarily expands more while its temperature is being raised to that of the hings after it is inspire<l, and thus it aids materially in the distension of tlie lungs. Frequent exposure of the bo ly to alternate heat and cold, either by means of air or water, undoubtedly gives tone and vigor to a weakly pei"son. Much care, however, must be exercised in the beginning of such hardening process. Humidity modifies the effects of the temperature of the atmosphere and causes it to produce de- pressing effects upon the body, chiefly by checking the perspiration. Great humidity with wannth is, h(nvever, usually bettei- V)orne than with cold. In i It *!■ |! 302 COXSUMPTION advanced chronic lun^ diseases, a moist, warm atmos- phere usually allays cough ; while a dry one appears to often irritate the lun^s. Malarial diseases, it may be noted, attain their greatest activity with the greatest humidity of* the atmosphere. Small-pox is checked by a very dry atmosphere, and cannot be even inocu- lated, it is stated, in the dry winds in Africa. Humidity favors the development and spread of infections gener- ally. It is well known that dry air retards decompo- sition, and that moist air is favorable to the growth of fungous plants. The eifects of movements of the air — winds, depend on three conditions: temperature, humidity and velo- city. Calm, dry Arctic air can' often be well borne, but when moving or moist it becomes unbearable, by chilling the body. The lightness or the weight — pressure, density or thickness, of the atmosphere is a very important con- dition of it. The pressure of the denser air at sea level being fifteen pounds to the inch of surface, and at an elevation of 16,000 feet only about half that, the air at the latter point contains only half as much oxygen, bulk for bulk, as at the sea level. At the moderate elevation of 6,000 feet, the quantity of oxygen in a certain bulk of air is 20 per cent, less than at sea level. In order to compensate for this, a person on ascending must and does breathe a pro- portionately greater volume of air. One going sud- denly from a low point to a high one, experiences shortness of breath, and breathes more rapidly even when at rest. When the altitude is not great, the ITS NATUliE, CAUSES AM) PREVENTION. 308 trill atinos- ne appears s, it may bo he greatest is checked even inocu- , Humidity bions gener- is decompo- the growth inds, depend by and velo- j well borne, bearable, by i, density or portant con- r air at sea surface, and alf that, the If as much el. At the [quantity of ler cent, less ^te for this, a athe a pro- going sud- experiences •apidly even .t great, the brt'athing gradually becomes less frecjucnt, but deeper, fuller and longer, and remains so. Hence the large chest of the mountaineers. The ])hysioIogical effects of the lessened pressure and thinner air, as one ascends, i» not usually perceptible below 2,000 feet. Some remarkable effects of altitude on animal life are mentioned in a report of Medical Inspector Ciibbs, IT. S. Navy (Climatol. U.S., A. N. Bell, A.M., M.l). New York : Wm. Wood k Co.). On high mountains in Peru, almost inider the etjuator, " positive degrees of heat and cold meet on such sharp lines " that they cause " violent reflex action, shock, ])aralysis," sevi^re and sudden pains in men, causing them " to double up ; " and such etiects on birds while Hviuiif in the air as to cause them to fall suddenly to the ground <lead. As in direct contrast to the effects of the thin air of liigh mountains, it will be well to notice here some effects of compressed air. For centuries, observations on these have been made by physicians and others, in diving-bells and in special air-tight chambers. The caissons used in recent years in constructing in deep water the foundations of great bridges have afforded excellent opportunities for the study of these effects. Parkes asserts that at a pressure of 1^ to 2 atmospheres the pulse and respirations become slowei-: and that it is said (Foley) that more oxygen is absorbed and venous blood becomes red, like arterial blood. Doctor Andrew H. Smith, of New York (Phys. Presb. Hosp., late Surg. N.Y. Bridge Co.), in a work on this subject (Detroit: Geo. S. Davis), remarks as follows : " Compressed aii* tends to expand the Ij 304 (joNsuMrnoN I '; ;i| ;; pulmonary air VL'sicles, increasing thu vital capacity', and may ))c uhcmI to restore the permeal)ility of aii- tubes ocelu<le<l bv exudation or otherwise. In its ft/ cliemico-physiological action, the indications are to hv found in the increase wliich it occasions in the amount of oxygen taken up in the hmgs, and the improved condition of the blood which results. This is shown in the more rapid oxydation of the tissues, in the greater activity of the vital processes, and in increased muscular power. . . . The narrow chest, more oi- less flattened, . . . with restricted respiratory movements, ac(|uires under the mechanical action of the condensed air and the im])roved nutrition of the respiratory muscles a greater range of excursion ; the inideveloped aniemic and vulnerable lungs become more or less expanded ; and the frecpient and super- ficial respirations less frequent and deeper. . . . Oertel gives it great prominence, and believes it will often accomplish much more than change of climate." in CLASSIFICATION OF CLIMATES. In systematic works a variety of climates is described : cold and warm ; cold and damp, and cold and dry : warm and moist, and warm and dry ; ocean climate : forest climate ; and that of much elevated regions — elevated climate, distinguished by a thin or rare atmosphere, cool, dry and changeable. Space will not permit of details here descriptive of these varieties, nor of the climates generally recognized as most suit- able for the different temperaments and constitutions of consumptives and the various stages of the disease. ^ff* ITS NATURE, CAUSES AND I'UEVENTIOX. 305 I capacity, lity of air li. In its s are to )>(' he amount ; improved is is shown aes, in the n increased 3Ht, more or respiratory al action of ition of the jursion; the nsrs become t and super- [eper. . • • ieves it will of climate." is described : d and dry : ean climate ; id regions — hin or rare »ace will not ise varieties, ,s most suit- ionstitutions the disease. A few leading ])ointH, however, may be notice<l as l»earing more especially on prevention. A Cold Damp Climate is not favoral»le to hinnan life and health generally, an«l .slioiild be avoided by consumptives. A C()l«l Dry Climate is, on the othei* hand, invigor- ating and generally acknowledge<l to be best of all for persons who are pre<lisj)o.sed to the disease, or those in the earliei* stages who have strength to take con- si<lerable exercise in the open air : this being more (Nspecially the case if such be their native climate. When consumption develops in a cold dry clinuite it is owing to \ocii\ influences : for the most part to habits of life therein ; and usually, much more than to anything else, to housing in close, overheated rooms and inattention to the skin, bv which extra work is thrown on the linigs. In Warm or Tropical Climates there is less outlay of energy, which suits debilitiited feeble persons. Warm and Moist Climates, such as those of Florida, the West Indies, and Madeira, are enervating, and now u.sually only advanced or excitable cases, or those with a good deal of cough from bronchial or laryngeal irritation, are sent to them. Warm Dry Climates are more resorted to, as being more suitable to a larger proportion of cases : such are those of Mexico, southern California and some parts of the Mediterranean coast. Arizona and Egypt (upper) afford the more extremes of this sort of climate. Consumptives in these have no difficulty in keeping out constantly in the open air, while they 20 306 CONSUMFI'lOX : •m ^: J.J get abundance of sunshine. Some persons in tlu^ earlier stages, or when only predisposed to tlu* disease, derive benefit, which, however, is not infre- quently only temporary ; especially, in my experience, in those accustomed to a colder, more tonic atmos- phere. Within the present year, a nuin, aged forty-five, a native of Ontario, still well able to attend to his business, and who with reasonable care in his native climate might have lived many years, if not to n fairly advanced age, went to California, near Los Angeles, and died in less than a year. OCKAN CLIMATE. The most notable characteristic of sea air is its very high degree of purity and freedom from organic emanations — bacteria, vapors, gases, and from pai'- ticles of dust, or substances liable to irritate the lungs. Hence from this alone life at sea is of great benefit to some consumptives. Usually the air has a calming effect on the nervous system, too ; its temperature is more equable than on land; and its oxygen is iiyt- parently in a most active, invigorating condition, — highl}'^ electrified and ozonous. Sea air is somewhat more humid than land air of corresponding latitude : but so far as this may be objectionable, in itself, in certain cases, other qualities fully compensate for it. It is possible that the iodine, chlorine and bromine in the air at sea may have a beneficial — an "alterative," effect on the human organism. Like many other of the climatic conditions and effects, however, these are not yet well understood. ITS NATl RE, CAUSES AXD PREVENTION. :m oiiH in tho iHcd to tbi' i not infre- r experience, onic atnios- 3d t*orty-tiv«\ ttend to lus in his native if not to a ia, near Los aea air is its , from organic nd from par- bate the lungs. great benetit has a calming nnperature is ,xygen is aP' o- condition, — X is somewhat iding latitude ; ,le, in itself, in »ensate for it. ,nd bromine in |n " alterative." [many other of ever, these are Amongst sailors tlie mortality from consum])tion is comparatively very low. William S. Wilson, M.R.C.JS.E., etc., in " The Ocean as a Health Kesort," has drawii attention to the fact that " the registration return of deaths amongst sailors of the mercantile marine show that the pr(j[)ortion of deaths from con- sumption as compared with those from other causes is ten times less than it is among.st the English land |)opnlation," and that between the ages of fifteen and forty-five, it is " sixteen times less at .sea than on land." Sir B. W. Richardson has stated that in 1850 Bowden showe<l that, while the dtjaths from consump- tion in the British army were, in the Line, 8.9, and in the Guards, 12.5, per 1,000 men, in the Navy, from 1830 to 1856, only 1.76 per 1,000 died of it. A life at sea, for one predisposed to phthisis, and inclined to such n, life, is certainly to be reconnnended, though rarely absolutely necessary. A sea voyage, especially a long one, is in some cases advisable. Cases in which the most decided and permanent benefit followed a long sea voyage have come under my oKservation. The risk or seasickness, however, of undue excitement and anxiety in rough weather, with the impossilnlity of turning back if the life proves ol)jectionable, must not be lost sight of. Modified sea air, as on sea-coasts and islands, is in some cases of benetit. It is not so pure and uniform as out-at-sea air, Imt in a few localities is a very good substitute. The nature of the soil, aspect, prevailing winds and other conditions, nnist be very carefully considered in making a selection in any case. 308 CONSUMPTION ii !i HIGH MOUNTAIN CLIMATE. High mountain air is peculiar in that from its tliinnesH and smaller oxygen supply it necessitates greater activity in the breathing movements; an indispensable condition in both the prevention and cure of consumption. Elsewhere have been noticed some effects of altitude on the body functions. By the fuller breathing, the smaller (luantity of oxygen in the air appears to be compensated for in suitable cases, and general permanent benefit follows. A young man with a proportionately small or inactive chest, either partly or wholly inherited, or acquired by habit, and so predisposed to the disease, usually benefited by residence in a well-elevated locality. A more active respiratory function is forced upon him : he is compelled to breathe deeply. The membrane forming the air chambers instead of continuing in a measure contracted and thickened, becomes active, distended, thinner, and positively cleaner, and the function of respiration is more perfectly carried on. The lungs become a less-titted soil for tubercular deposits. If such young person have no particular home ties or business relations, and would be as con- tented away from home, and with means to go with- out deprivation, and make ii home there ; and more especially if he be somewhat indilierent about his health or condition, and not disposed, from careless- ness or other cause, to use special means at home for removing or overcoming his predisposition, he prob- ITS NATURE, CAUSES AND PREVENTION. :iOO ably should be advise<l to make liis home in an ele- vated locality. He will there be actually compelled to take longer, fuller inspirations. These are the sort of cases that are most benefited by such a climate. Persons in the earlv stao-e of the disease, not much debilitated, with little or no fever or consolidation of the lung tissue, nor bleeding therefrom (luemoptysis), and especially if the disease b? making* but slow progress — very chronic, and who are not of an excit- able or " nervous " temperament, are not infrequently benefited, and permanently, by an elevated climate. Those further advanced, or who cannot take consider- able exercise, or are erethic, easily excited or dis- turbed, should not risk the change. It is (|uite generally believed that inhabitants of high mountains are exempt from consumption. It appears, however, that development of the disease is not unconuiion n(jw in some elevated cities in Color- ado and Mexico. Local influences — overcrowding and want of ventilation, eventually produce their predisposing effects in high as well as low cities. Once introduced, it spreads to the susreptil)le by infection. On the authority of Parkes (Pract. Hygiene), " Al- though on the Alps phthisis is arrested in strangers, in many places Swiss women on the lower heights suffer greatly from it; the cause is a social one ; . . . ill- ventilated, low rooms : . . . constrained position, poqr food. Scrofula is very common." It is now known, Parkes says, that " great 310 rONSUMPTloX Liii^i i ELEVATION IS NOT NECESSARY for the euro of phthiHis." " It would even seem pos- sible that, after all, it is not indeed elevation and rarefaction of air, but simply plenty of fresh air and exercise, which are the great agents in the euro of phthisis." Neith(?r is it necessary, certainly, for the prevention of the disease. Ziemssen (Clin, lect.) says of mountain health resorts, — " Their success seems to depend not so much, if at all, on elevation of site as on the purity of air and exercise of the lungs." Davis, who is decidedly favorable to moun- tain climate, in his latest work, referring to respira- tory gymnastics, writes as follows : " The respirator}^ muscles are strengthened and trained to involuntary mountain deep breathing. The chest can be gradu- ally thus enlarged quite as much as by high-altitude life, provided only one will be sufficiently persever- ing." On another occasion he writes respecting moun- tain-air : — " It often stinnilates the ambitionleas and lethargic to take the all-needed exercise," — of the lungs. Denison (of Denver) says, " The mountain configuration of most high places invites to hill- climbing, and the increased radiation of heat due to rarefaction and drvness is a natural incentive to, or substitute for, exercise. These agencies are to be pi'eferred because they are natural ; and besides the enforced observation of artificial rules is less impera- tive in high altitudes." It is clearly evident then that the best authorities, those who have had best opportunities of knowing, believe that the beneficial ITS KATFRE, TArSES AND PREVENTION. 311 results of mi elevated climate are produced by an increased respiratory function in pure air : as Zienis- sen remarks they depend on the purity of the air and the exeicise of the lunjrs. Furthermore, theoretically, we wouM naturally suppose that tlie lungs could be gradually enlarged and respiration improved with greater safety — less i-isk from hfemoirhage, by careful lung exercises at home, in the native climate, than by a comparatively sudden change to an elevation. Localities with practi- cally pure air and other favorable conditions can be found in almost any country or part thereof, FOREST CLIMATE. Forest climate, especially that of pine forests, has been highly extolled. An abundance of sunlight can of course be always obtained in a piece of open. The effects of forests on the atmosphere resemble in some respects those of the sea : more especially do they equalize temperature and humidity. Pine and other balsamic trees produce an aseptic condition of the air which is thought to be highly salubrious ; while the pine especially, in its root growth, greatly favors sub- soil drainage. Doctor A. N. Bell (in Climatology, as quoted) says, " The effect of forests on the electrical states of the atmosphere, and the generation of ozone, is doubtless a force of great influence, adding to the general salubrity, and under some circumstances giving them special potency." Forests afford great protection from the effects of winds, cold or hot ; and also from " malaria." It is said the interiors of the 812 CONSrMl»TI()N : great " dismal " swampw of Virginia and the Carolinas are not insalubriouH, like it is near the treeless borders. Doctor F. L. Oswald relates (Pop. Sci. Monthly, Vol. XI ) that the Prince de Ligne wrote an essay " On the Location of the Earthly Paradise," in which he calls attention to the fact that " paradise traditions, in locating the garden of Eden, differ only in longi- tude, not in latitude. The latitude keeps always near the snow boundary, a line just south of the regions where snow may fall, Imt will not stay on the ground. It passes through Thibet, Cashmere, northern Persia, and Asia Minor, reaching the meridian of Europe neai- the centre of the Mediterranean." Doctor Oswald adds, " We may doubt if in the most favored regions of the New World, human industry, with all the aids of modern science, will ever reunite the opportunities of happiness which Nature once lavished on lands that now entail only misery on their cultivators," and this because of the " insane destruction of the forests." ^- v«. ACCLIMATIZATION. Acclimatization is a physiological process the pos- sible injurious effects of which upon non-vigorous, debilitated, susceptible persons, it appears to me, are almost entirely overlooked when considering the ques- tion of a change of climate. The human body when in fair health can soon adapt itself to much changed surrounding circumstances, but not without a certain expenditure of force or energy. Consumptives have little or no energy to spare for anything not indis- pensably necessary. It is well known that the body ITS XATURE, CAUSES AND PRRVENTION. :U3 functions of a liealthy vig;oi'ou8 man are sonietinies much tlisturbetl by tl»e change. The disturbing eti'ects are probably exerted, in a measure, upon every organ and function. Can we ever be certain that any bene- fits whicli may be produced by a change, as, for ex- ample, from a cold or temperate to a warm climate, where, it is true, the lungs may be relieved by more work being thrown upon the skin, will compensate for any ill effects which the change, particularly at first, may exert upon other organs of a consumptive ^ Respectnig the change from a temperate to a ti'op- ic^l climate, Parkes (E. A., as (juoted) says, " How soon the body, when it has become accustomed by length of residence for successive generations to one climate, can accommodate itself to, or bear the con- ditions of, the climate of another widely <lifferenrt, place, is a ([uestion which can only be answered when the influences of climate are better known. •. . Certainly it would appear that, in India, there is some evidence to show that the pure race [European], if not intermixed with the native, does not reach V)e- yond the third generation." Sir W. Moore (paper before Epidemilog. Soc. Lond., '91) maintains that great as is the power of accommodation possessed by individuals, each race is especially fitted for certain climatic conditions, which tend sooner or later to eliminate the unfit. He believes that an infusion of native blood is essential to the permanent existence in one climate of immigrants from another and very diverse one ; and gives examples, in respect to In<lia and South America (Can. Health Jr., Ap. '91). .•n4 CONSUMPTION : U'l . ! Cluiiij^in^ to a coklei* cliiimte, .strant^e an it may appear to soiiie persons, seems to prcjduee a ^ood effect eventually. Respecting Anj^lo-Saxon and Celtic races ^oinjr to live; in a climate with a lower mean temperature and greater variations than their own, Pai'kes ol)serves, " We have the experience of Canada and some parts of the Northern American States, in which, if the food is good and plentiful, health is not only sustained, but is perhaps improved. Certain it is that in those countries the European not only enjoys health, but produces a progeny as vigor- ous, if not more so, than that of tlie parent race." The intense effects of great altitude upon the body have been already noticed. At lower levels of course the effects are less marked. At an altitude of about 3,000 feet they begin to be decidedly perceivable : (juickened pulse and respirations, lessened spirometric capacity and increased evaporation from the skin and lungs (Parkes). Doctor Charles Fayette Taylor (Proceed. N.Y. Acad, of Med., Oct. '94) informs us that " Whether it be due to the increased action of the heart in the rarefied atmosphere, the constant ham- mering of the nerves by the winds and the fierce sun- shine, or all these and other causes, people in those [elevated] regions have a thin and tired look, and it is found useful and often necessary, especially in cases of women and children, to visit lower, damper and more germ-laden regions" in order to recuperate. To the susceptible " nervous " consumptive such a climate is not suitable. ITS NATITUE, CAUSES AND PHEVENTIOX. n\ri CHAN(JE OF CLIMATE UXCfcUTAIN AND EMPIRICAL. With the proscnt want of knowlffl^o ui" tlic relations to, or efiects upon, the body ot* tlie numerous and vary- ing conditions of tlie elements of the atmospliere, or climate, some special conditions of the oxy<(en of whicli have yet to be referi-ed to, the practical appHcation of climate to consumptives either as a preventive or ther- apeutic remedy seems to be in most cases uncertain in a high degree, and is almost wholly empirical. Over half a century ago, Sir James Clark, M.D., etc. (Cyclop, of Med.), wrote, — " Since the nature of phthisis has been more fully understood, the expectations fronj climate as a means of cure have greatly abated, hence it is much more justly considered simply as a pre- ventive . . . during that peculiar state of deranged health observed before the disease has manifested itself in the actual development of tubercle. If it has dis- appointed as a curative agent, how far can it be relie<l upon as a preventive ? To be sure, before the in- creased debility consequent on the formation of tubercle the patient could the better bear acclimatiza- tion. One of the latest authorities, Doctor Squire, already quoted, remarks that, " Years ago Madeira was the chief health resort of consumptives, and all sorts of cases were sent there. Next the south of France came into vogue, and thousands of consumptives flocked to the Pyrenees or to the Riviera. Then came the turn of the mountain climates and the Engadine, and the clear air of the snowy mountains and altitudes of Switzerland dispute the claims of the dry sandy S1G rONSt'MPTlOX 1 I ' :ct iii ])lainH ol* K«;y))t juid tlie African hIioioh of ihi" MimH- terninean or tliose ol' its more attractive northern coasts." These places, Doctor S(|uire adds, " are all suituMe health resorts for consumptives, if j)ropei- selection is made of the kind of case to he sent to each." Just so: hut with the present limited degree of knowledge on this suhject, how is the selection to he safely made ? Doctor Davis (hefore cited) ohserves that, the selection of a climate is frecjuently made easier hy watching the effect, in a given patient, of different kinds of weather, especially of hright, warm, moist days, and bright, warm, dry ones. And Doctor F'rank S. Parsons (Ed. " Times and Reg.," med., Phila.) says, " The only way to test a location " is for the person to " try the various localities," if practicable, and make a permanent abode in the one which agrees best with his individual constitution. In view of all this, and of well-known highly unsat- isfactory results from change of climate, especially from a cold to a warm or thin atmosphere, sliould not, usually, every other remedy be first tried in all cases of consumption oi- of predisposition to it ? ESSENTIAL CLIMATIC ELEMENTS OH CONDITIONS. There are certain elements of the atmosphere which are absolutely indispensable for either the successful treatment of consumption or for removing or over- coming the predisposition. These relate particularly to the purity, temperature, humidity and movements of the air and, perhaps more particularly, to the condition and proportion of its oxygen. ITS KATUUE, CAUSES AND PREVENTION. 317 The degree of purity or non-purity of air is now usually based on the number of bacteria, or genns, it contains. Gases or vapors from the ground or other source may perha{)s be sometimes in the air which produce effects upon the body more important than those which ordinary bacteria produce, Init alx)ut which nothing is yet known. Germless air (practically so) is found only (a) out at sea, where germs are not developed, (/>) on moun- tains 5,000 feet high or upward, whence any micro- organisms which may be developed gravitate readily through the thin mountain air away to lower, heavier strata, and (c) on expanses of country, not too near a city, well covered by snow. As Doctor S(piire says, " Any snow-covered expanse has for a time — and in some places, as in parts of Canada, for a long time — a comparatively gerndess, and so a healthful air ; and these, though not at any great altitude, help to supply the want that mountain climates satisfy." Besides these, there are many rural localities in most countries sufficiently elevated for good drainage, with a sandy, gravelly or rocky soil, or a richer soil with sufficiently abundant, salubrious vegetation, in which the air is sufficiently pure and restorative. The temperature of the air is a condition upon which its suitability for consumptives has been most largely based. These persons usually require, most of all, " tone." Warm air is relaxing rather than toning. The colder the air that can be borne, or within reason- able limits, the better, the more oxygen it contains, in a given bulk, while at the same time the more !!:^:i i », u. ■Y I p?j i.i 318 CONSUMPTION : invigorating this vital olcment HueiiiH in itHelf to 1x3. The air shouM not 1k^ humid. Tho efiectH of sudden changes of temperature, as already stated, are invigor- ating : and Parkes says, " It is astonishing to find how- well even phthisical persons will bear great changes of temperature if they are not exposed to winds." At Nice as the sun approaches the hori/on the ther- mometer falls 25° F. in an hour. Sudden changes constitute one of the most marked features of th(» thin atmosphere of high mountains. At Davos (Switz.), less than six thousiind feet above the sea level, a special resort, summer and winter, for con- sumptives, the uncovered thermometer has registered 166° F. by <lay and fallen at night to 16' F. ; a "drop" of 150°. The degree of humidity of the atmosphere is a con- dition of much importance. In treatment of the pre- disposition, or excepting cases of irritable cough, a comparatively dry air seems decidedly most favor- able, as promoting free transpiration from the skin and lungs. In relation to this point, especially the exhalation of moisture from the lungs, Denison (Den- ver) says, " Does it not stand to reason that this tran- spiration of surplus vapor is a most admirable vehicle for carryoig away effete matter, waste tissue and the germs of disease ^ " Thirst for fluids is greater, and fluids slio^id be taken freely in a dry atmosphere. Winds, on account of their directly cooling eft'ect on the body, are not well borne by the susceptible consumptive, particularly moist winds. Moderate m(jvements of air, however, are essential to good ventilation and the purification of areas pf country, ITS NATURE, CAUSES AND PREVENTION. 319 as well as of dwellin^H. A locality Homewluit shel- tered from winds by forest or hill is hest. Sunshine, direct, when not too stronif, is indispen- sable ; and abundance of it is most desirable. A " sunny " climate has vvev been rej^arded as salu- brious. Herei!! is one of the principal advantaj^es of mountain climate. A thin, mountain atmosphere may, however, permit Sol's i-ays to pass too freely and powerfully. The readiness with which the sun's rays pass through this thin dry air causes the great difiei*- ence in temperature l)etween sunshine and night. The Oxygenic condition of the atmospheres has undoubtedly a most important bearing upon health and vigor. There appear to be im[)ortant vital variations in the quality of this life-giving element, oxygen, in different localities, as well as in its (|uan- tity: variations arising doubtless through the influ- ences of sunlight and electricity, and about which we yet know but little. To' these variations is ])robably due, in the main and directly, the well-known dif- ferent feelings, of exhilaration or the opposite, com- monly experienced by persons on going from one limited locality to an adjacent one : some voicing these feelings by saying, " I feel like a different person," in such and such a place. It is not improb- able that the topographical aspect — the slope, of a limited locality toward the sun, the geological struc- ture, or the subsoil water, may through the influences of electricity and sunlight affect and change the quality of the oxygen over the place. Sir Benjamin Brodie, Doctor (now Sir) Benjamin W. Richardson and Schonbein have proved that there are at least 320 CONSUMPl'lON : ii' 1 two distinct conditions of oxygen. Doctor Richanl- son has shown that warm-blooded animals become narcotized and eventually die when forced to breathe over and over again the same atmosphere, although by a process of washing, it is kept free from the toxic products now known to exist in expired air : " The process of life ceasing, not from the introduction of a poison, but as by a negation, or a withdrawal of some principle extant in the primitive oxygen which is essential to life." (" Field of DivSease," etc. Phila. : Lea Brothers & Co.) By passing an electric spark through this oxygen, after it has been breathed, it acquires again its life-sustaining properties and pro- duces no ill effects on the animals. These different states of this element Doctor Richardson distinguished by the terms vitalized and devitalized oxygen : — active and negative. It need hardly be stated that, as a rule, those places in which the oxygen is most active or vitalized are most salubrious, and most desirable as places of residence. SPECIAL LOCAL INFLUENCES AND CONDITIONS. The most commonly recognized special local condi- tions which affect the atmosphere over a locality and give rise to the noted differences, if we except those which give rise to foul air — " malaria " and other noxious gases, are (a) the nature of its soil, and (h) the slope (klima) or aspect of its surface toward or from the sun. The evaporation of moisture from the earth's surface absorbs heat ; while the con- densation of moisture in the air liberates heat. [jtor Richanl- imals become ;ed to breathe lere, although from the toxic •ed air: "The itroduction of kvithdrawal of oxygen which ," etc. Pliihi. : electric spark n breathed, it ;rties and pro- rhese different [1 distinguished ;ed oxygen : — DC stated that, xygen is most )us, and most )NDITIONS. lal local condi- a locality and except those ia" and other its soil, and irface toward noisture from kiile the con- liberates heat. ITS NATURE, CAUSES AND PREVENTION. 321 Cloud or moisture in the atmosphere intercepts both the heat from the sun and that radiated from the earth's surface. It is easv, therefore, to under- stand that the air over a locality from which, by I'eason of a slope, say, toward tlie sun, the water of a rainfall flows freely and rapidly away, or (piickly penetrates deeply into a gravelly or sandy soil, is ditterent from that over a flat-surfaced locality with a close retentive soil, or from one sloping from the sun : not to mention many othej' topographic features which atf'ect atmospheric conditions. Again, the absorption and accumulation of the sun's heat by the earth s surface sjil or crust, varies not only with the natiu'e of the soil and the slope of the sui'face sunward or otherwise — the angle of incidence, but also with the nature of the vegetation on the surface — trees, shrubs, gi-asses, etc. And again, the temperature of the sul>terranean water, wliethei- manifested by warm or hot springs, or only by deep wells, aflects the temperature of the soil and hence the coinlition of the atmo.sphere. Yet again, as the heating and cooling of water takes place in accordance witli a law difterent from that by which land is heated and cooled, a lake modifies and e<}ualizes the temperature of the ail* in its vicinity, making it cooler by day and warmer l)y night. Hence the reconmiendation to place a vessel of water near house plants at night to lessen the effect of cold or frost. Forests, too, produce a like modify- ing effect. It is well known that the temperature in forests everywhere is higher in v«rinter and lower in summer than in the open country. 21 322 CONSUMPTION D < ^h Jf im True it is that the particular air over any one locaUty is soon changed by the movements of air going on everywhere and giving rise to winds more or less perceptible, and is largely replaced with air from other localities. Still, when the weather is calm and there is not nmch atmospheric movement, the air over a given or favored place remains for a considerable proportion of the time but little changed. Besides, notwithstanding the movements, as the local topogi'aphical and geological conditions which influ- ence and change the air are incessantly operating and producing their effects, there will always be a slight difference, as in temperature, humidity, vege- tative emanations, etc., sufficient to affect electric, oxygenic, or ozonous conditions. And although these changes and conditions cannot be detected by any chemical process or instrument yet known, they may ba perceptible, as already intimated, to the sensitive nervous structure of a deranged human body : or even if not sensibly or clearly perceptible by, they may yet produce effects upon, such a body. SELECT, HOME CLIMATE. What is usually meant by change of climate is a change to a part of the earth a considerable distance away : to a warmer or colder, moister or drier, more equable or sunny, or a more elevated climate. More- over, the change is made apparently usually as if the climate of the country in which the consumptive had recently lived had been the cause, or this in a measure, of the consumptive condition ; which it is almost needless to state, is not often, or, alone, never, '' \ ITS XATUllE, CAUSES AND PKEVENTlOX. ;J2.s er any one lents of air winds more ;ecl with air weather is c movement, iinains i'or a ittle change'l. s, as the local , which influ- tly operatinjr always be a imidity, vege- attect electric, although these fcected by any ,wn, they may the sensitive man body: or l)tible by, they .dy. )t' climate is a irable distance or drier, more llimate. More- mally as if the le consumptive L, or this in a [n; which it is »r, alone, never, the case. It is true that in some climates it is not so easy as in others to overcome or remove a predis- position to consumption, and some tend more than others to Favor the development of a predisposition : in other words, in order to prevent a predisposition, or increase of it, it is necessary to be more careful in respect to habits of life in some climates than others. For reasons already above partly explained, two localities, adjacent and limited, may have over them an atmosphere varying in a number of important characteristics, highly favorable, or much less so, to life, health and vigor. One may, therefore, often make a most beneficial change of climate without going far from home or leaving one's native country, or even county, to which one is accustomed or accli- mated. A change especially from a flat, damp, frosty soil, to a more elevated, sandy or gravelly dry one : from one much exposed to cold or damp winds and less to sunshine, to one more protected from storms and more exposed to the sun : and from an urban to a rural one, is often absolutely essential, in either prevention or cure, in consumptive cases. And such a change is in nearly all cases all that is necessary, especially on this continent above the forty-fourth parallel of latitude, inland. A specially favored, select or ideal locality for a person predisposed to consumption, or in an early stage of it, would be one in a rather cold climate, such as northern Europe, the northern United States, above the forty-fourth parallel or higher, and Canada, presenting the following conditions or characteristics : a somewhat elevated plateau, not too flat, or a hill- mm 324 CON'SIMPTION lu t -I side, sloping toward the sun, with a sandy or gravelly soil and choice vegetation, as perhaps balsamic, odor- ous trees or plants, near a small lake, preferably be- tween the lake and a forest-covered mountain or hill, — the latter protecting it from the severity of the usual prevailing cold winds, and with all, warm subter- ranean water supplying the lake. In such a place, — with such salubrious conditions, the usual seasonable or other objectionable climatic changes would be reduced to a minimum. In the countries above mentioned there are many localities in different sections with characteristics much .(s just pointed out to which consumptives could resort. There need then be no leaving home and friends for distant countries : no risk fron^ acclima- tization. In the British Isles, surrounded as they are by the ocean, a sufficiently dry locality for certain cases, as with a strongly marked predisposition, is hardly obtainable. In sach, notwithstanding the salubrity of sea air, a drier, more invigorating climate may be necessary. Doctor J. E. Squire says, " The influence of pure dry air, an equable temperature with bright sunshine, so beneficial to those whose lungs are weak or already damaged by tubercle, cannot be obtained throughout the year in this country, and are sought abroad by those who can afford to travel." In concluding the general subject of climate, it may be noted that those peoples who in centuries long past migrated from the Paradisian belt, along "the snow-boundary," northward to the colder regions have <leveloped into greater, more powerful nations than those who migrated to the warmer latitudes southward. ITS NATURE, CAl'SES AND PHKVKXTIOX. :^'2') or gravelly uimic, odor- il'erably be- linorhill. — of the usual anil subter- i\\ a place, — il seasonable ft woukl bo >re are many haracteristicH Bptives could [ig home and fron\ acclinui- id as they are c certain cases, ion. is hardly the salubrity iiniate may be The influence •e with bright ^ngs are weak jt be obtained nd are sought 1" llimate, it may jenturies long lit, along "the tr regions have nations than lies southward. CLIMATE OF CANADA AND ADJACENT STATES. The particularly salubrious and invigorating climate of Canada should be more widely known. Tlie mean elevation of the country is only between 300 and 400 feet : less than half that of this continent, or of Europe ; and oxygen abounds. It is hardly anywhere flat, but naturally well drained. The mean tempera- tiu'e is lower than in those parts of Europe in the same latitude. The extremes, however, of l)oth cold and heat, are much modi fled b}'' the great mid-continent lakes. The two principal seasons are Sunnner and Winter : the intervening seasons being shorter. Spring is a very bright pleasant season, but of short duration, so rapidly does Summer succeed the Winter. " Leaf and blossom are not unfolded one by one : but as if by magic," when the snow is gone (Kingston). In Sunnner there aie rarelv more than three succes- sive days of great heat, when a copious rainfall, last- ing at most but a few hours, cools, and also purifles, the air. During the hottest days, there are almost constant cool breezes, and one never .suffers from the heat as do travellers in the East, or even in Southern Europe. Sunstroke is rare, practically unknown except in the largest cities. September, October, and for the most past Novendx'r, constitute a delightful Autumnal or lingering-summer season, in which rainy days are not at all numerous. The Canadian Winter, about which some persons who have little or no knowledge of it, speak dispar- agingly, is far from being so trying, either to healtli or comfort, as many suppose it to be. The cold, like ft/ mi I : I 1 I ll 320 CONSUMPTION the heat of auminer, wliile extreiiie in degree i.s not felt to be so. 'J'o persons accustomed to the damp, raw winter atmosphere of the British Isles the ther- mometer is a very imperfect indication of the relation to, or effects upon, the human body of the cold, yet dry, clear, sparkling, invigorating and cheering atmos- phere of a Canadian winter. Even the occasional thermometric-below-zero temperature very rarely lasts more than three full days, nearly always moderating before the close of the third. In illustration : When the sisters of St. Joseph were founding the Hotel Dieu Hospital in Montreal they lived twenty years in a building the walls of which were only a single board in thickness, and when snow fell in the night, so freely did it come in through the cracks that it had to be removed in the morning with shovels. It is related (Relat. <les Jes., pub. by Govern't) that " Tender, delicate girls who feared a snowflake in France," where a " slight frost caused them to take cold," here, a " long winter, armed from head to foot with snow and ice, produces, apparently, no other effect than to keep them in good appetite." Horses and cattle in the North-west, in many instances, are not housed during winter at all, and gather their provender from the sappy twigs above, and the grass beneath, the snow which they paw aside. January, the coldest month, I have always in my experience found to be the most healthy. Indeed the winter in this temperate region is on the whole a moat joyous Season. It was not of it that Homer wrote : " . . . Frost, which all the works Suspends of man and saddens all the flocks." ITS NATURE, CAUSES AND PREVENTION. 327 n've iH not the damp, js the ther- bhe relation tie cold, yet sring atnios- B occasional ' rarely lasts moderating Joseph were ontreal they ills of which 1 when snow through the norning with res., pub. by v^ho feared a rost caused armed from , apparently, 3od appetite." any instances, gather their and the grass ie. January, ly experience the winter in most joyous rote : The spotless sheet of snow spread over the gi'eater part of the country during several months of the year renders the air then practically germless ; while the rapid vegetation of most of the remainder of the year, with the dryness of the air, or absence of great humidity, is unfavorable to so-called " germ " life. Of all known antiseptics, probably frost and dryness — desiccation — are the best. The exhilarating influence of the air in Canada is doubtless due to its abundance of highly " vitalized oxygen." In this respect the country is hardly equalled by any other, except parts of the bordering northern States. More than a century and a half ago. Father Charlevoix wrote of it : — " We do not know of a climate in the world more wholesome; no specific disease prevails in it ; the fields and woods abound in wonder working herbs ; and the trees distill balsams of great virtue." The records of the British army show that Malta has been most favorable to the health of the men, with a mortality of l.l : Canada comes next: Nova Scotia, 1.4 and Ontario and Quebec, 1.5. In Great Britain, it was 1.7 ; Gibraltar, 2.1 ; Bermudas, 2.9 ; and Bengal, 5.5. It has been said that but for the use of " spirits," less necessary in the stimulating air of Canada, the mortality here would have been still lower. Life insurance companies accept rates in this coun- try up to a certain age lower than in Great Britain. Canadians and natives of the most northern parts, east and west, of the United States, who become con- sumptive, need not go abroad for change of climate flocks. 328 CONSUMPTION pi i . wliile ill the earlier stages of the disease (before the " softening " of tubercle and formation of cavities). After that time, it is in nearly all cases better to remain at home, the chances there being on the whole usually as good as anywhere, than to go abroad and die amongst strangers. Consumptives in other countries, in the earlier stages, who seek change of climate can but rarely do better than to come to the cold, dry, bracing air of Canada. I shall conclude with the following quota- tion from Kingston's "Climate of Canada" (IJawsons), to which excellent book I am indebted for many of the facts given on this subject : " Indian officers have passed directly to this country, and commonly with advantage; my memory recalls many, who, having returned to Europe and had their symptoms aggravated, found that a short re^iidence in Canada restored them to comparative comfort. Those esjje- cially who have come direct from India to Canada in autumn have noticed this change. One of my former pupils . . . became surgeon in the line and went to Bombay, where he contracted phthisis. He was sent to an elevated station . . . where he experi- enced temporary relief. He was then invalided and came back to Canada. In passing through Great Britain, the humid atmosphere was unbearable, and his breathing became very labored. In Canada, his breathing at once became easy. ... He felt, so he told me, as if he were breathing, not atmospheric air, but oxygen, so refreshing and invigorating it seemed to him." i H (before the of cavities). }S better to ling on the to go abroad tlie earlier 1 but rarely , bracing air owing quota- " (IJawsons), 3cl for many [idian officers 1(1 commonly many, who, eir symptoms je in Canada Those es])e- to Canada in f my former ine and went sis. He was re he experi- nvalided and rough Great [bearable, and Canada, his He felt, so atmospheric vigorating it PART III CHAPTEK XVI. JIELATTN(J TO THE TREATMENT OK CONSUMPTION. It is not my purpose to enter in this book into details of treatment, medical or other, nor of the symptoms and diagnosis, of contirmed cases of consumption, so far as they relate to the various special means appli- cable to the difierent stages of the disease, or the differ- ent constitutional conditions. Preventive measures, prevention of the extension of the disease, embrace the principles of what we term " cure," — constitute the chief part, and an absolutely essential part, of it. When mischief has resulted, however, and there is actual destruction of huig tissue from tuberculiza- tion, then usually measures must be adopted or reme- dies applied which are never necessary before such mischief. By the time tubercle has been formed, then in most cases nutrition has been so far interfered with and deranged that, while there is no specific remedy for the tubercular condition, the functions of digestion, assimilation and excretion require special attention and management, such as supply of special nutrients. fell" I 4! |1 i I* ! :<i ; III I 330 CONSUMPTION etc.; and every individual ease retjuires a somewhat different form or application of remedies. Persons other than physicians may read these pages, and it would be in a measure dangerous to give here details of special remedies, or the indications for them, lest some such persons might be tempted to so treat themselves or immediate friends suffering from the disease, — tempted to apply the remedies without con- sulting their physician. The proper treatment of this somewhat peculiar disease requires the utmost degree of medical know- ledge, and withal, time, patience and care in applying that knowledge. Moreover, no two cases of the disease are precisely alike, and every individual case, as just intimated, retjuires a special line of treatment, studied out and carried out. Hence much harm may arise from any measure of self-" doctoring," and indeed not infrequently does so arise ; especially from dosing with the " sure cures " advertised in the " papers." On the contrary, what it is my purpose to give here on this part of the subject, while it may, I trust, assist somewhat the busy general practitioner wdio has not been able to give sufficient time to fully acquaint himself with the generally recognized views of the most recent and highest large hospital authorities respect- ing treatment, as indicated by the recently increased knowledge of the causes and etiology of the disease, it should rather deter anyone not a physician from running the risk of doing himself or a friend serious harm by any action in this way based on only "a little knowledge." It is in such cases where the little know- ITS XATUHE, CAUSES AND PKEVEXTION. :VM a somewhat ,d these pages, to give here ions for them, ,6(1 to HO treat :-ing from the 1 without coii- vvhat peculiar medical know- re in applying i of the disease il case, as just Ltment, studied irm may arise ,nd indeed not from dosing " papers." \e to give here , I trust, assist r who has not fully acquaint lews of the most irities respect- intly increased of the disease, (hysician from friend serious •n only "a little he little know- ledge becomes the " dangerous tiling " : not in the pre- vention of the disease by removing and counteracting well-known causes of it. In no other circumstances is a small amount of knowledge so dangerous as in attempts to rectify a deranged or diseased human body by any sort of medicinal treatment of it. And probably in no other disease is it so dangerous as in this peculiar and fatal one. No one thinks of applying such knowledge to a deranged or damaged watch. DIAGNOSIS : DIFFERENTIATION. The discerning and eminent physician, VanSweeten, was, it appears, the author of the maxim, "Qui bene diagnoscit, bene medebiter " ; sometimes translated as " Diagnosis is half the cure"; but more intelligibly as, Who accurately diagnoses cases — determines their exact character accurately, will treat correctly. Accurate differential diagnosis of consumption in the early stage requires time ; time to make a most care- ful, searching, thorough examination of the patient : to (a) make as certain as possible as to whether the disease l)e really consumption or not ; if consumption, to (6) obtain as clear a knowledge as possible of the nature and extent, or progress, of the local diseased condition and of the general constitutional effects already pro- duced ; to (c) learn of the special condition and con- stitution, history, etc., of the pati* '^ and to (d) find out the probable or possible more active remote causes of the pretubercular condition. No two per- sons, either in health or disease, being exactly alike, ^sam II J lV.i'2 CON'SIMHTION HO, JIM stattMl, i^vi'iy cuHc iT(|uii«'s ji HoiiK'wlmt ditterent c()Ui'.s(' «)1' ticatiiu'iit, t'HjM'cially us relating to nutrients, treatimuit of the stomach, bowels, skin, etc., — requires special medication: this without reference to, or aside from, the different stages of the disease. It is known that the most experienced, successful and eminent [)hysicians, in tlie most exten jractice in London and other large cities, whom young and less experi- enced practitioners are naturally inclined to accept in a measure as examples, devote much time to the examination of each of their patients and to the consideration of the special individual states before prescribing foi' them : especially shovJd this be the case in connection with consumption. These remarks seem necessary, because sometimes with busy practitioners tlu; temptation to make a somewhat hasty examination a d diagnosis, of what ap])ears to be a " well-marked ' e, is too great to be rtisisted, and also because occasKjnal cases have been treated as those of incipient consumption which were not of this nature, but which in the hands of other practitioners were found to be perhaps hydrothor x (water on the chest, in the sac formed by the two layers of the pleura); oi* what is worse still, occasional cases have been treated as other diseases which later proved to be tul)ercular consumption. Whoever makes a hurried examination is liable to mistakes of this sort : such occur for the most part only from too little time being given to diagnosis. It need hardly be added that the reputation of the physician as well as t)ie life of the patient is at stake. As if" i ITS X ATI UK, t'Al SES AM) I'HKVENTION. :i'M\ wliat (litiereiit ^ to nutrionts, etc., — requircH ice to, or aside It is known and eminent tice in London id lesH experi- ed to accept in 1 time to the ts and to the 1 states hefoi-e ad this be the luse sometimes ion to make a krnosis, of what too great to be ;ases have been ion which were lands of other ps hydrothor ' x led by the two still, occasional ises which later on. Whoever >le to mistakes part only from losis. It need k' the physician at stake. As Doctor J. K. S((uire says, " Early detection of t)ie dis- ease being all -important, it is essential tliat skilled examination should be obtained. . . . And, tir.st. we must accept the fact that th«* recognition of com- mencing tubercle in the lung is no easy mattei', only possible when the chest has been skilfully and car«'- fully examined, and the sputa, if any, microscopically investigated" (Hyg. Prevention of Consump.). The patient is the one most interested, and in case liis j)hysician, or the one to whom he applies, ai.pears disposed from any cause to make a hurried exaiuini- tion, he may very properly courteously draw atten- tion to this point, and ask for an opinion based on a most searching investigation ; accepting no other. There are a few persons, it is true, with "very little the matter with thcM ' who imajiine they liave con- sumption. Almost any pliysician to whom such may apply can usually soon convince himself that there is no consumption, or even tendency to it, in the case. SOME SIGNS AND SYMITOMS OF CONSUMPTION. The general configuration and appearance of a consumptive patient, even in an early stage, with the history and certain rea<lily obtained and common symptoms, will be at once an important guide as to proliabilities, but will afford no certainty of the presence of tubercle. If after proper examination of the sputum, tubercle bacilli are recognized, unmis- takably, especially if by an expert, it is presumable that there is then no que.stion as to the nature of the disease : even although other symptoms and .signs r :]:U COXSUMPTIOX : i ! do not .stnjngly indicate tuberculoHis. Zienissen, how- ever, reminds us of tlie old fundamental maxim, never to base a diagnosis, not even in such a case, on one single symptom. Then it will be remembered that, on the other hand, there may be pulmonary tubei-- culosis without the bacilli being always found in the spittle ; especially in the acute miliary form and in cases in which these organisms are encapsuled — encased in fibrous tissue. Like doubt, as we know, accompanies the recognition in later stages of the true elastic fibre ; it is, too, now known that pigment granules and myelin cells are found in other lung afi'ections ; and Ziemssen has shown that myodema — contraction waves of the attenuated pectoral muscles — may be produced in persons emaciated by other causes than consumption. This high authority re- commends the spirometer, and also the scales, as aids in diagnosis, as well as guides during treatment. Guided by four years' experience with the former, he advises that only the i-elation between the volume of expired air and the stature be taken : then the spir- ometer serves to corroborate other symptoms. When the proportion of stature to vital capacity falls below one inch to three in a man, or one to 2.6 in a woman, he says, " we may infer a considerable disturbance of the respiratory organs," the nature of which must be learned from other symptoms. EARLY TREATMENT: DELAY MOST DANGEROUS. It may be laid down as a fact, indeed, a maxim, to be impressed upon both patient and physician, that the only treatment that is likely to be s^uccessful ITS XATUKE, CAUSES AND PUEVENTiON. :335 iiiissen, how- laxim, never case, on one nbered that, Dnary tuber- found in the form and in iucapsuled — aH we know, :ages of the that pigment 1 other king ■j myo<lema — toral muscles bed by other Authority re- 16 scales, as ;ig treatment, he former, he he volume of hen the spir- ,oms. When ,y falls below in a w^oman, isturbance of hich must be NGEROUS. a maxim, tu ivsician, that be successful in consmnption when it is once established, is EAKLY treatment. This appears to be more especially the case with this than almost any other disease. With early approved treatment, based on sound diagnosis in respect to all indications an<l re(iuii('- ments in the case, and properly eai-ried out by the patient, there need be no anxiety or fear of the result To the PATIENT, to anyone who has a predisposition to this disease, and is perhaps at length awakened by some symptom of it, as loss of appetite for food, some languor and loss of strength and weight, with perhaps a little " shortness of breath " on occasions or slight cough or throat irritation, or to any friend — parent or other relative, of the same, it may be said, n)ost emphatically, when conscious of danger, lose not a day in consulting a physician and applying the proper remedies. Don't wait in such circumstances until there is a bad cough, or pain in the chest (often signifying very little), or perhaps specks or sti'eaks of blood come up from the lungs with very little etibrt or with hardly a cough at all. Go at once. The same respecting delay applies to persons who have had no marked predisposition, either hereditary or accjuired, but who have had persistent cough for some weeks, whether from a " cold " or bronchial trouble, or dust or other irritation. Self-treatment, except in so far as it relates to prevention, as given herein, niay be worse, do more harm, than delay. All so-called " medicines " publicly advertised to cure consumption are, without a single exception, FRAUDS, j)Ui'e and .sinjj>le. However nujch good or virtue there may be in the " cure " or " dis- f1 H^ 1 m. , fi ! 51 330 CUXSUMI'TION coveiy," however much benefit otiier persons may ))o.ssibly liave chanced to derive from it, it is liable to do the next one much hana on account of the entirely different body constitution and condition, — liable to cause direct injury to certain body functions. It may act as a stimulant and cause a better feeling for a time, while the disease is progressing, perhaps fast, all the same ; or it may calm or subdue a cough, when the cough, as in a measure nature's method of relief, ought not to he so subdued. I would say to all con- sumptives, as you value life, . ver be tempted, by any promises of, or apparent, benefit or " cure," to incur the risk of subjecting the delicate, deranged organs and function of your now particularly sus- ceptible body to the influence of a compound of drugs about the nature of which you know nothing what- ever, and moreover, which was originally compounded l)y one who could not possibly know anything what- ever about your special case — your body constitution or condition. Pause, think, consider, and you will surely see the inconsistency of any such course or treatment of your case. It w^ould be almost certain to be worse than delay. Dangerous as is delay, less harm would likely result from it than from self- treatment. It is to be hoped that the time is not far distant when those persons wdio seek to extract money from their suffering fellow-creatures by prom- ises of cure through advertisements in the "press" will be subject to legal action for fraudulent practices. To the PHYSICIAN who i,;ikes charge of a consump- tive patient, or of one in whom tubercle is suspected, it may Iv well to say, put not the patient off* with i.'-f '1; ! ^ ITS NATURE, CAUSKS AND PREVENTION. 337 mouH may is liable to he entirely — liable to ctions. It feeling for 3rhaps fast, ough, when )(1 of relief, r to all con- ieinptecl, by • " cure," to B, deranged 3ularly mus- md of drugs thing what- ^ompounded thing what- Iconstitution d vou will h course or lost certain delay, less from self- Itime is not Ik to extract s by prom- I" press" will actices. a consump- s suspected, lit ott' with only a tonic, a cough mixture or an alterative, for a day. At once, after due examination and considera- tion of the case, lay <lown a complete course of treatment, and impress upon the person most inter- ested, the surt'er.r or his or her most immediate friend, the importance of having every detail of it carried out. Difficulties and discouragements in getting in- structions fully or properly complied with are all too commonly encountered by the physician, and much tact and firmness are often re((uire<l in this behalf. INDICATIONS AWD REMEDIKS. These, so far as the specific disease itself is con- cerned, are yet, and probably always will be, almost entirely such as are termed hygienic — physio-ther- apeutic — on the " lines of nature." All authorities recognize this, now, to the fullest extent, perhaps more decidedly than ever before. The proposed new remedies of scientific experimenters, all, I believe, are regarded as of only secondary importance, — as only aids, adjuncts, in the treatment When Koch, for instance, a few years ago, introduced his tuberculin, he from the first particularly recommended that all the usual hygienic remedies — abundance of pure out- door air, sunlight, suitable nutrition, attention to the skin, etc., be not neglecte<l but enjoined in all cases. Without these, we can do nothing; without these, to the full extent, everv other means will fail. Of all of them, pure out-door air is most important. Hence, to the now generally recognized treatment is so fre(|uently prefixed the term "open air," "fresh air" or "out-door." As Ziemssen says, the " fresh air treat- 22 hi a Ml 1 338 CONSUMPTION meiit occupies fii-st place." Man}' recent remarkable recoveries from tu])erculai- peritonitis (tubercle of the serous membrane investing- the bowels), apparently from simple exposure of the diseased mend)rane to atmospheric air by a surgical op<']'ation, seem to indi- cate, more clearly than ever, that tlie virulence of the bacillus is destroyed, even when active in the tissues, by free exposure to the aii-. These I'emarks apply to the oreat principle of treatment only. Many othei- remedies, often indicated, in certain cases and sta(»;es of the <lisease, I'ecjuii'e special con- sideration in their application to each particular case; ]>ut as stated, cannot be discussed in this book. A general outline of treatment may he cf)nveniently noted under the following' divisions : First of all, it need hardly be said, all the predis- pcisinj;' causes of the disease, so far as they can be made out, must be remove<l, as fai' as ])ossible, in order to prevent their further action or influence. These relate to occupation — in-door, stooping", dusty; to location — dampness, impure air: to habits of life o-enerallv — sedentarv, overworked, breathiuii', diet, etc : and to any previous morl)id body condition. Second : An immediate impoi'tant cause, apparently in all cases, being a want of full respiratory capacity, efl'orts must be at once made to remove this by increasing the capacity. Authorities who have given most attention to this subject recommend special lung exercises or gynuiastics, or it may be " hill clim})ing," sometimes pneumatic chaml)ers, for im- proving the lespiratory fmiction. Inhalation of oxygen, in order to supply to the tissues and fluids ITS NATURE, CAUSES AND PREVENTION. 330 ■emarkable rcle of the apparently •inbrane to nn to indi- ence of the the tissues, ks apply to in certain special con- bicular case; book. !onvenieiitly 1 the pre«lis- they can he possible, in r influence, ing, (lusty ; bits of life lithino-, diet, idition. , apparently )ry capacity, )ve this by have given lend special ay be "hill >rs, for ini- halation of 's and fluids a larucr amount of this clement, may be desirable. Some care is reijuired that not more of this be sup- plied than is assimilated or used by the system. Third : Cravfully considered means must be adopted for the proper nutrition of the body, in accordance with the powers of di;j;e.stion, and, not forgetting, assimilation — utilization after digestion : for which probably a certain amount oi' oxygen is (lemandnl. Not onlv an; assimilable, nutritious ordinarv f(;ods re(piired, but not infre«iuejitly s[)ecial foods — minced beef, cream or oils, malt extracts, phosphates, etc., should be provi<led, as the .system retjuires, or the indications in each indi\ i(liial case point to. Fourth: Attention must bej-'iNen to the skin, that it may be clean and active, an<l .so aid in a measure in the respiratory function, to relieve the lungs. While the absolute cleanliness and activitv of the skin are in<lispensable to the best results of treat- ment, the cool or cold bath, in its various moditied forms — sponge, hand, rain or sheet — at suitable tem- peratures, as present indications point to, gives tone to the entire body and lessens its susceptil)ility to sudden changes of temperature, and hence to " colds." Huflicient clothing, preferably light and porous, to pre- vent chilliness, must be worn : but not too much of it. Fifth: Attention to derange<l .special, local or gen- eral functions is often neces.sary, even in the early stages: — of the stomach, bowels, kidneys, liver, and of the circulatory, nervous, or muscular system. The cough may recpiire s[ ecial treatment, as external appli- cations, or inhalations. " Cough mixtures," it niay be said, should never be given. In this connection 340 CONSUMPTION : ITS NATURE, ETC. |M *-'^o the question of exercise, active, or passive — as in mas- sage, to l)e prescribed in accordance with the vigor of the individual, for improving the circulation, and through it the nervous and muscular systems, may be mentioned. As Hippocrates advised, — " the patient may take his walking exercise if walking agrees with him ; if not, let him rest as much as possible." Anti- septics may be indicated. Other conditions or symp- toms, such as night-sweats, ha3morrhage, diarrh(«a, of advanced cases, need not be noticed here. In conclusion, it may be observed that, the simpler and less complicated the treatment, in respect to any morbid local couaition, so far as it is at all consistent with, or meets, the indications, the more successful it will probably prove to be. Any morbid action or state that has evidently been the result of the tuber- cular condition, will usually gradually ' disappear as the general bo ly condition improves, and may usually be left in abeyance, if not excessive in degree and giving too much trouble or inconvenience : such as mioderate cough, slight pains, nausea. On the other hand, any such state which has operated as a cause, may the more likely demand special treatment. Improvement of the respiratory function will alone promote nutrition, usually in a large measure. With a suitable diet, nutrition will be still further pro- moted and improved. And with proper attention to the skin, improvement in the circulation and general invigoration will result. Full, deep breathing of pure sunny air, proper food, and a vigorously acting skin, constitute the trinity of treatment for consumption. Other remedies, often necessary, are quite subordinate. -as in mas- )he vigor of lation, and snis, may be the patient agrees witli ble." Anti- ins or synip- Jiarrhc^a, of , the simpler spect to any ill consistent Hiiccessful it lid action or of the tnber- disappear as may usually deirree and nee: such as On the other d as a cause, itment. ion will alone asure. With further pro- r attention to n and general ,thing of pure f acting skin, consumption, e subordinate. INDEX. Accliinati/jjition .... I'^ffects of - Air, Compressed I'me Thill, rare .... tubes Alcoholic hever.i>;es Animal sources of liacilliis - Animals, domestic, Hyjfieiie of - Appetite Athletes and consumption - Atinosi»heric air - - . - Atmosphere and climate Atmosphere, The, and the body func- tions - . - - ' - ;500- Avoidinjf infection . . - 240- Bacillus, The(oftub.T'j?«^) - - -ID, Air jfrowth cf - 47, and soil . - - . Animal sources of - Hot any of - - - coli communis Cultivation of Diflferent forms of - 84, Kffects of environment on Fla^rella or cilia of • outside the body - relations of, to the dis ^ase Sporing and multiplica tion of - . - Typhoid, of - Sources of Whence comes 3aciHi, How they enter the body in dust of rooms, etc. in flesh and milk - • 18: Inoculation of Numbers tfiven off by consump tives . . . - lack yard. The - . - - lathing, general and skin - lathing and Christianitv Cold . ." - . conver iences - History of - • - Inner (within the bodv) Public .... I'AdK 31-2 .114 ao3 20 3(t2 22 237 2!t4 2;i(i 118 20 2!>!) 30.1 275 , 41 ISKi 1!»9 liX) 4(5 83 41 198 87 85 199 44 43 82 185 40 188 187 192 189 186 227 238 240 266 291 239 242 240 Hath, Uuin or shower - f%»lt in ... Value of - • - Ilwlrooni .... Blood and respiration Clean Blood-serum antidote Bo<ly factor, Prevention of - Breathing, Acts of cai>acitv Full . Imjierfcct - imperfect, Klfects of Causes of consumption enumerated Two essential Cause and effect - Canadian climate Carpenter's theory Chest walls. The - Dimensions of Dimensions of, in disease Children and food Management of consum Cilia of air tubes . Cilia of bacilli Civilization and consumjition Cleanliness, Absolute - within Climate .... Canadian Canadian, Salubrity of Classifleation of Cold .... defined Dry .... Essential elements of Forest - . - . (jocal .... Moist .... Mountain Mountain, not necessary Ocean .... of United States— northern Oxygenic conditions of - Select home Special, local conditions of 200, L38- ptive 239, I'AOK 292 209 208 228 30 80 140 207 25 26 233 249 93 03 142 04 114 325 (>-U>2 23 30 104 237 271 22 85 1.10 276 242 149, 327 parts 298 325 ,328 304 305 298 305 316 311 323 305 308 310 306 325 310 322 320 342 INDEX. r p. I |L 1 '^J f\ • . . 1 :; i \ 'n I, fli ^ I'AOK Climate -Warm ;M)5 ClothiiiK 24 :i Cofffu '2:57 Colds, No.fle(te«l - - - - 14S I'ri'venti')!! of - - - 260 Cookery 15:{, •l.M Coiiiprcssed air 3U3 Corniiiiiniiability of conHumptioii 12, 1S4 CoiiHuiiiption, Causes of •• - (W He iKieo ori^fin of - - 100 Forms and names of ■ ;iH Nature of ... us not always from infection 202 I'revention of - - 212 Some signs and sym]i- toms of - - - Treatment of Curability of consumption - Cure of consumption. No specific for - Cure, pure air first .... Cures, fraudulent - - • 'S.W, •M.i 329 1« 17 .•i:{7 Deductions respecting: cause Deductions coricludintr I'art I. - Deei» breatliin}; ... io;"i- l)efecti\e respiration - Defences of the bmly - Defensive wal s or coverin^rs of bod, Details of hyj^iene. Attention to - Diajjnosis of consumption - its importance Disinfectants .... Disinfection of rooms • Dietary . . . - - Dormant or latent jrcrms in body Doniestic animals, Hyj^ieiie of - Draughts of air - Dust ...... Bacilli in - - . - Dusting, dry and damp Dwelling-house cause. The - The, in prevention Kating, A voiding excess in - slowly .... with regularity Kducation. Preventive Kmpjoyer.'s liabilitj* Kqiployments, Various Kssentials of health Kxces's, Avoid all- in eating Excretory functions Excreta retained in body Exercise .... General respiratory Special respiratory 108, ^',•^, 270, 221). no 208 2:}{ 110 Kif) i:i7 222 ~m 28(J 281 2:J4 0(1 204 277 270 187 270 150 Facts in respiration Flat chest, The • - 2ao - 23.5 . 235 ■ 280 - 288 ■ 202 226-243 - 245 - 230 - 240 - 70 - 243 - 251 - 1M ■ 35 - 131 PAOK Flesh and milk ai.d infection - • lH.5 source of infection • V.f' Floors, ('racks in, etc - - - . •^•^i Flushing rooms 2.!:i Foods IM, •2M Nutrient, for the predisjwsed • 2);4 Special Hi', Fresh air, (Quantity of, in ventilation -iM Oerms, Destruction of, not enough - - 207, 21 Non-virulency of • 'Health lectures .... ]taniphlets precepts .... Heredity and the bacillus - ami the body factor or predis position ... eivsily overcome or eradicated (ieneral influence of - Statistics on ... Hospitals for consumptives Impregnable bodies first Impure air a most important cause , 21!) 203 2.S7 2S7 24ii 1-J 12i 13.i l:«i 121 290 180, 101, 180- Intection, Avo ding of butter and cheese Elucidation of from animals from meat and milk General remarks on misunderstood FreveTition of Infectiousness of consumption A degree of, evident - Cases of, in ])ractice Clinical facts on Evidence opposed to the - Exi»erimental evidence of History of ... Historical evidence of Modifying circumstances in Statistical evidence of Inflannnatory action in tuberculosis Isolation not sufficient Lmdlord's liability Latent or dormant germs in body Lectures en health Legislation, health. Lines of Limited re-piratoiy capacity - 09 Lungs, Anatomy of miy be easily enlarged Small the organs most commonly affected . - . . ' Marrying Meat and milk, Infectiousness of Milk and meat, sources of infection 240, 275 '2i: l4;j 27 l!).i Ifii liW llfj l.iT 1;- 27.1 I.H4 l.M 17(i is: 17: 17! KiJ Kit i 17J lOi 5; 2(i- 2SI ( iX|( 28 ;»; 24; 2 3 97- KK e isiii 2' 25) 1!) INDEX. 343 ,(1 infection tjrce of infection etc - 153, or tlie prediiiposed ty of, in ventilation 'Ai.K.I lV)i V.f'l I'l-I I ■SA'i ion of, not lency of • 207, 217, 210 I bacillus - Ddy factor or predis- conie or eradicated luence of - III - - - - isiunptivcs KffcctH of, illustrated Forms of - 2Q|jB>ut-door treatment ■)iit-doors, How to stay to be let in - )vercro\vdin(f and death-rate KerHiifbt of cases hervvorlt ..... »xy<,', n and climate in body .... 287 287 241) 12.') 12i l:i:i t;f(i 12 296 ies first U important catise iiiK - ;er and cheese ation of animals lieat and milk il remarks on [lerstood ition of consumption - )f, evident - ti ])ractice c:ts on )pposed to the - ital evidence of - 217 - 14:; 24«, 275 - id; - IM 189, lito 'rebreathed air, Klfects of 180-KM l.-s:) 17 171 Kit evidence of circumstances in evidence of tion in tuberculosis fflcient ity .nt yerms in body th til, Lines of 01 V capacity of asily eiilargred . ms 1 . most - 175 - 1C( ■ 5i - 2(l- - 28! - !H - 28; - :8; 09, 24! - 2: - 3' 97-l(Nl cotnmonly ■ ISlinitarium lilk reKulations .... Iiinicipal preventive measures . louth, not for breatbiii;,' thioiiffh Cose, The, the projier air passai^e notification. Best subsiituie lor Dccupation as a cause of consumption Choice of ... 2(!: 'amphlets on health - 'arents and children - 'areiits. Words to 'arasites - . . . arasilic diseases, Kxainples of liaj^ocytes - . . . leura and pleurisy oisons in blood and tissues breathed air 'osture. Bad and t'ood l:*'.' 'iccepts. llealtl m 'ledisposition, as a tlist cause 1^" Nature of 27n 'retubercular cmdition 1<^1' l*^^ preventive measures reventability of consumption i;m 171 'revention of consumittion ''■ Division of subject for Lines of action in , Facility of - Principles of 16|'ure air first in i)reventioii first in cure 207, I'AOK 2!iO 28;{ 234 234 293 2r,9 2fifi 2(14 337 258 •-;3() 111 '.04 244 319 34 287 272 271 47 51 138 25 81 30 252 143 24 C 210 205 281 214 212 224 21(5 213 215 22() 33 cmedies, FraudiUent for consumption emedy, No siieciiflc . espiration. Defective espiratory capacity . exercises, H:eneral si>ecial function - or^^ans St r, Infectiousness of - 29 sources of infection - li) 335 3i8 337 99, 248-250 - 26 - 251 . 253 • 19 - 21 . 245 - 215 Sanitariums, State, public . Saprophytes aiul parasites - School pupil manaicement ■ Schools and health Scrofulous condition • Skin, The, and bathin^f Sleep Soil and prevention vegetation Body Damp Draiiiatfo of • (Jround - Spittle or sjiit, Disposal of - liacilli in State preventive measuies - Sunli},'ht .... Want of, a cause • Table of chest dimensions . I hnifj- capacity Tea . . . ■ . Tenement houses Tobacco as a dejiressant Trachea (wind-pipe) Trealmetit, Dangers of self- Karly, all important of consumption • Out-door— pure air Frinci])les of, only Pure air Trinity of - Tubercle, what it" is bacillus Diffusion of - Formation of in other tissues and ai Tuberculosis Hecovcry from Spread of, in lunjH's 5, 150, L'nderclothitiif Veetation and soils - Ventilation .... Cost of methods Formula to jfuide in in sickness Want of breath - ,,, , . . tliP 1,'reat want Water, drmkinj,'' . . : I'ure Weather and colds Wind-pipe ■ . . . Words to parents - PAOK - 29« - 47 - 292 229, 272 - 72 • 238 • 246 ■ 220 - 75 09 72 - 150 289 22« - 279 - 180 ■ 283 • 245 • 147 - 36 - 104 • 287 - 228 • 155 22 330, 335 273. 335 • 32!> - 337 ■ 338 - 337 - 340 - 39 - 40 - 58 52 5t» 10 (il 58 .243 75 2:io 230 231 232 •^77 210 211 235 238 149 Q.) nials n