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Les diagrammes suivants illustrent la mAthode. 1 2 3 4 5 6 bii ;i LABORATORY OF THE INLAND REVENUE DEPARTMENT OTTAWA, CANADA. BULLETIN No 382 LINIMENT OF CAMPHOR ■J'i:5G7— I i '1 . ! LABORATORY OF THB INLAND REVENUE DEPARTMENT OTTAWA, CANADA. BULLETIN No 382 J L. VINC" LINIMENT OF CAMPHOR {Linimenlum Campborx) OTTAWA, August 16th 1917. P q., K. C. B. A., L. Ph., Deputy Minister of Inland Revenue. SlK, , bcB to h.nd you . ,q»r. «po„ 94 »mpks ot Uniman. ot Camphor, pur- returned ; . , „, . .pj„ iqu'i reauires Liniment of Camphor The British Pharmacopoeia (Edn. 1914; req"'^^ Div Jn" 1; .£ Empire. Ar.chi. (pe.-n»t) or S».me 0,1. bu, „0 ,.h» oJ « t« ame percentage amount ot Campnor, out aucv« "" "nftv three (53) of the samples now reported are made with Cotton Seed Oil and ? ui"d by the formula of the British Pharmacopoeia, are techn^aUy Sulterat^'on^iis account. Nineteen (19) of these samples -re genuine, so far 4 1 ^ as the content ol camphor is concerned ; and if judged by the formula of the Uni- ted States Pharmacop.i-ia. are st i.tly correct. Tlure would appear to be no Rood reason lor regarding cotton seed oil as in any way mfenor to Olive Oil. m the preparation of this liniment, and 1 have judged these samples as genuine. The followinj, summary presents the results of our work : Samples coli-'ctcd by mistake 12 " Liniment of Camphor '^ Total 106 it Liniment of Camphor. Made with Olive Oil ^^ samples. Made with Cotton Seed Oil 53 Total. 94 Containing above 20 per cent, camphor 40 samples. Containing above 18 per cent, camphor 15 Containing above 15 per cent, camphor 18 Containing less than 15 per cent, camphor 21 Total. 94 The camphor content is the most important feature of this Lmiment. Owing to the volatilitv of this component, and for the purpose of allowing reasonable variation in manufacture, the U. S. P. specifically permits the camphor content to vary from 19.5 to 20.5 per cent. The B. P. prescribes no limits of the kind. Bearing in mind that this is our first systematic examination of the article, it mav be permitted to accept samples containing at least 18 per cent, of camiphor as satisfactory; and perhaps those containing at least 15 per cent, as doubtful; such judgments, however, are not to be regarded as precedents, for future deci- sions. If this suggestion be accepted the samples, as regards camphor content, may be classified thus : Genuine, both as regards camphor content, and solvent 36 Genuine as regards camphor content | lo 21 Doubtful. . Adulterated Total. 94 As already noted, those samples which contain less than 18 per cent, of camphor. (39 in number, or 41 per cent, of the total collection) are undoubt«lly to be regarded as adulterated; although for thb time passed as doubtful where as much as 15 per cent camphor is present : and do not furnish the purchaser with a satisfactory article, or the physician with an efTctive remedy. Nme of them contain less than 10 per cent, of camphor; and several of them considerably less than this amount. ■■-■i I have on previous occasions found ouse to remark upon the caielcssncss, .„ «.,rse. exhibited by the retail drug trade in Canada; (See Bulletms 175. 225. .(,-, 315 339. 342. 344); and it is sufficiently evident that the Adulteration Act, ; 'pi. i„^ to the inspection of Drugs as well as Foods, must be enforced as vigorous- U ,n regard to the first named class of articles as to the latter. Whether or not ,Ih. fact that most of our Apothecary shops are more truly described as Candy. T„l.acco and nick-nack shops, has anything to do with the lack of attention given ,„ (luality of drugs proper, must be left an o,^n question ; but it is suggestive. and cannot be allowed to pass without remark. „ „ . ., ,-0 I beg to recommend publication of this report as Bulletin No 382. I have the honour to be, Sir. Your obedient servant, A. McGILL, CbieJ Avalyst. 6 BULLETIN N«. »»- Nam* aad Ad^«a Coit of M«oufM2tt 7P."121t 7tl.'..'iO 7H7Z 7S7;.'6 7!«727 Nitr. DruR A Chen. Co. Hull' tax. (i. McdlUvitry. ilalifnx llioitnUro«&Co. H*•< 2S,H«'1.41«>', j " 17 :J0 17 (Ml.. ., iporiUro s,87 H.SI l,47;i."i r MACKXRN. INSPECTOR. 73. H 45.3 »3.e .14.7 41.0 — 2.1.30 2S.32 IS. 72 18.92 11. M 11.00 12.04 12 30 14 48 18.60 1.47al! ne«Btlve 1 47411; positive I.4732I.... I 4731... 7«S27 (ieniiln€' 7tM2X (Inniilne. 7Mi2il Ddiilitrnl. 7H727 Ailull«at«d; Camphor very low. (Vl»fl2 Oonulnn. tVI.HflS Doubtful. fi3S«4!Adull«rBted r.-»mphor too low. il3H6A|Adult«rat«d : Camphor j too low. l>3H0u!l)ouht'it. K. AKSBIf AULT. INSPECTOR. 88. 3 32.7 SB. 4 87.8 10 8 19.20 7.87 22.88 10.95 3.87 19.70,1.4702 23.22.1.4700 30.22.1.4723 S.ea' 1.4701 cesatlve 60652 Oe ailoe. I UN O. FRROUSON. INSPECTOR. 63.3 es.i 88. 3 43.3 34.4 31.80; 31.40 31.90 23.14 18.48 19.04 14.88^ 14.83 8.48^ 1.4703|. 1.4703J. 1.47331. I 1.4732i. I 1.48081. nc«at.v« PC DCghtln negative positive nesatlTe WHVi Ft. a WTi. ounJ Unlment, I i.ui-chnied In mUtake 60684. Utnulnu. 60678lOe' : .1. a< "o camphor c .11' int. but made wltn coii .n need oil. 60601 Adaltoratwl ; Camphor very low. 60783 Oenulna. 69784 Qenulne. 69768 89766 69787 Genuine ai to camphor content, made wltb cotton ned oil. Adulterated: Camphor too low. Is Chloroform Unimant. purchased bjr mistake. 8 BULLETIN No. 382- Nature of Sample 2 Name and Addrem of Vendor Coat Name and Addren of Manufacturer or Pumltber M given by the Vendor Manufacturer. Pumliher DISTRICT OF QUEBEC CITY igi7 April 10 10 10 10 Liniment de 7100lJA. E. Franca>ur. 394 St Jean 12 ozs camphre. Quebec. j 71002 A. L. Jolicoeur. 338 Ht. Jean, Quebec. 71003 N. W. Kinear. 13« St. Jean Quebec. 71004 W. B. Rogeni. 44 de la Fabri- 7100fl LaRocbe & Co. 4 de la Fabri- ; que, Quebec. 00 1.05 1.05 .20 BO DISTRICT OF QUEBEC PROVINCE-O. BRO- April 12 12 •■ 22 22 Liniment Liniment de camphre . E. Rouillard, St. Ourtais. P. Q. 5601 EuK^'ne Foumlcr. St. Jerome P. Q. 5617 Ed. Cirignon, .*■! V P. LAVAI.LEE. INSPECTOR. 43.5 15.08 14. 141. 474"! Ipcsitive Polarization In 2 dm. tube at 20° C Deg. Venz. Angu- lar Deg. Camphor 0.8360 . 0.9020 .0.8214 .0.8355 24 20.8 25.3 22. ».32, 12.61 7 21 10.32 8.77 13.28 I I 7.63 11.50 10.54 9.85 10.89 9.66 95 71 97 91 6807; Doubtful 6tal. BO ('hainpaKnc & flls. Men! trOal April If. ir. T.ininu'Ut C\iin))ii< 1 of r. 7t74<5 74717 17 7474S 17 7174'.l 17 j i 747oO \. Hiinm-id. r,G2-^ Slierbroakf 12 St , \'ntrt'-I);iim' t>3 S. 9. Tripp. Arnprior ! 12 ozs 1 1 . 00 73r)(t0 73r) ra INS PEOT( JR. s.ill .n Camphorated Oil . . 43.3 14.9 46.9 31. r 15.01 5.16 16.26 10 79 14.03.1.4748 4.74 1.4748 1 15.84 1.4712 10.81,1.4741 ! positive neiratlve positive 74056 Doubtful. 74057 Adulterated : camphor very low. 74058 Doubtful. 74064 Adulterated : Camphor very low. 1 \ RICKEY, INSPECTOR. . 61.6 43.8 48.1 57.6 70.2 21.36 15.18 16.67 19.97 24.34 20.38 14.11 15.81 19.07 23.54 1.4707 1.4745 1.474,5 1 . 4?46 1.4735 negative positive negative 73.552 73563 73.590 73591 73592 Genuine. Doubtful. Doubtful Genuine as to camphor content made with cot- ton seed oil. Genuine. 12 BULLETIN No. 382- 1017 April May Nature of Sample a Name and Addren of Vendor CMt 1 5 Cti. Name and AddrM* of Manufacturer or Puanliher aa given by the Vendor Manufacturer. Fumliher DISTRICT Of KINOSTON Linimpnt of Camphor April 78301 7H302 78303 (■een'8. Belleville J. S. McKeown'8 Belleville The Belleville Pharmacy. Bel- leville. 78304 W. J. B. Davimn. Port Hope|9 ozs 78305 T. O. Watson. Port Hope. . 1^ ozs 60 l.'iO no IM) 1.20 Vendor DISTRICT OF TORONTO Uniment of ' Camphor . [ 7778:« 77784 777S,'i 7778(1 77787 M. E. Vanzant. 884 Yonge St Toronto. i of tbe Chief Analyit lAMKS HOQAN. INSPECTOR. 46.3 B9.7 06.4 sg.o es.e 16.05 24.16 22.20 30.46 22.76 15. H5 24.13 22.74 20.21 23.00 ; . 4740 1.4713 1.4747 1.470el. 1 . 4709 , IpoiUtlve jnexatlve {poaltive netpitive 7S301 78302 7ia.a 7H304 783a'> Doubtful, (ienulne. Genuine as to camphor content. Made with cotton seed oil. (ianulne. Genuine. 11 J. DAOER. INSPECTOR. [..ilH'lleil Oil Camphorated.; 46.6 I 30.6 i.alM'lloii Camphorated oil.' 26.6 I 59.0 ! 20.0 15.67 10.60 9.29 20.46 7.24 14.76 1.4747 10. 17 1.4747 3.70 20.25 6.65 1.4720 1.4704 1.4746 II .1. UAGER. ACTING INSPECTOR. r.ihilM Camphorated oil . ^ol,| .IS II. P. .Stren*th. I..ii>i'lli'.0 22.54 59.0 67.6 44.3 M.4 23.50 15.26 20.25 21.80 20.96 24.26 14.56 20.15 1.4747 1.4710 1.4745 1.4741 1.4745 I positive negative Positive 77783 Doubtful. 77784' Adulterated : camphor 1 very low. 77785 Adulurated; Camphor I very low. Genuine. 77786 77787 Adulterated very low. Camphoi' negative positive negative 77701 77702 77703 77704 77705 Genuine. lenuine. Doubtful. Doubifi^i Genuine. posIUve negative positive 65157 Gcnu'ne as to <»mphor content : made with cotton seed oil. 65180 GenuUie. 66188 Genuine as to camphor content ; made wltr cotton seed oil. 65104 Doubtful. 65199 Genuine as to nmphpr content ; made with cotton seed oil. I!i 1!I17 April May 14 BULLETi:f N«. 382- Nature of Sampit; «! a 3 3 !> 2 3 3 X, N;nnp and A'kircw of \>n(l*>r Cost Name and nddren of Manufacturer or FurnlitttiT a* Klven by the Vendor s a 3 CIS Manufacturer Furriislicr DISTRrCT OP MANITOBA -initncnt of ( '.itiipliir 7."._'ii(i|i;. 11. Il.itc. Tr.ii.s-mna 7">.'iir(^iw^in'«i Onii! Store. Portauo la Pr.iirif 7.-.2r,2;Pl. M. CannifT. I'ortacB la Prairiiv 7."..'iW r.lni'olH Park Ilriiu To. Uf.'.i .-.-■lil K Main St., \Vinnii)Cic II. (iilliiilly. splkirk ozs 7.'> i.:{(i I . 5() 7."i 1 v'eudor. DISTRICT OF SASKATCHEWAN- .\pril IMIJnimi'ii! fampi cif 7701 l|Ki>*iiiT's Drag Store. Rogina. . ri)21 ■Da.') Herina. O. s. Milchell, Woyburn McKlnnon'8 Ltd. Weybum. \V. C. Sweet. Yellow UraM . 12 OZ)l nozs 12 ozs 1.00 1.00 1.00 Vendor . DISTHICT OF ALBEBTA— April 23 " 23 '■ 24 " 24 May 11 Mninxml. of Camphor .52607 52fl0S .'■J2IMW 52010 520 Jasper Pharmacy. Edmonton The Owl Drug Store Edmon- ton. Line's Pharmacy, Edmonton Heath's Drug Store. Edmon ton C. H. Harry. Calgary :) bot» 00 " 75 " 75 •■ 1.50 1.20 Vendors . DISTRICT OP ROCKY MOUNTAINS — April 10 May Liniment of Camphor. os3or> 08381 08382 0S4OO 08415 A. Reeves. Enderby. B. C. . . R. E. Berry Ltd., Vernon S. A. Muir & Co, Vernon.. . . Creston Drug ic Book Co., Creston. Cranhrook Book * Drug Co Cranbrook. 75 1.50 1.25 1.20 l.SO Vendor. ». 382-. 15 LINIMENT OF CAMPHOR ■CM 'urnlshiT ndor urrUshor Itispoctor'a Report ^ not an expresdon opinion) Reeulu of Analjila Optical rota- tion k 20O O Camphor Calcukted »,a Refractive fS Index 11^:15^0 i^. 35 ; ° 1 <^ 1 1 gSfo |5 1 Ill 1 Remarks and Opinion of the Chief AnalyM onA — .1 I', COSGROVK. INSPECTOR. 10 3C 14.16 22.74 8.05 21 23 1.4700 1.4737 1.4707 1.4737 1.4707 aegallve poalUve negative posUvs ; negBtive i 75260 76261 76262 75263 75264 Genuine. Adulterated : Camphor too low. Genuine. Adulterated : Camphor very low. Genuine. WAN- i II HALL, INSPECTOR. 18.63 19.90 17.18 16.48 18.24 1.4736 1.4705 1.4706 1.4743 1.4728 poaltive Negative podtive „ 77014 77016 77021 77022 770?8 Genuine as to Camphor content: made with cotton wed oU. Genuine. Doubtful. Doubtful. Genuine a« to Camphor content ; made with cotton teed oil. EBTA— 17.44 8.40 17.10 18.62 31.46 1.4711 1.4736 1.4736 1.4/04 1.4736 negative positive negative podtive 62607 52608 52609 62610 52611 DoubtT.i. Adulterated : Camphor very low. Doubtful. Genuine. • Genuine as to Camphor content : made with cotton aeed o'l. IIN8 - riios. PARKER. INSPECTOR. 60.0 67.6 68.0 60.5 63.0 20.81 10. OS 20.11 20.0£ 21. 8« 20.14 19.66 20.20 21.36 21.12 1.4605 1.4676 1.4678 1.4680 l.472i poeitive trace negative " potdtive 68366 68381 68382 68400 OS- le Genuine aa to camphor content : made with cotton seed oil. Genuine. Genuine. Genuine. Genuine aa toOanipho* content : mad* with cotton seed all. 16 BULLETIN No. 88S- 3 Q NMur* or Sample Nkme uid Addrna of Vendor Co«t I i 9 Nuaa and AddraH of Manufacturer or FumUher aa liran by the Vendor Manufacturer runilaher DIHTKICT OF VANCOUVER — 1017 April 18 Liniment of Camphor . 18 10 7570S 7S70H 75710 7ii7 7671:* Ldw'h l>ruK Mu>re. (ieomia A Main Sin.. H. Vanroiivor. DrowuH b Beaton. Pender A Main Sti., Vancouver. Capltola Pharmacy, Davie A Tburlow 8U.. Vancouver. Central Driu 8tore 16 Cor- dova 8t. w . Vancouver. «t The Reliable Pharmacy. Com. mercial Drive A 3rd Ave. Vancouver. 12 on 7."i 1 SO 1.00 1.2ft no Vendor. Vendon. DISTRICT OP VIOTORIA- Atni 27 Liniment of Camphor. I 27' 30 30 30 7S766 76767 78700 Dean A Hlicock, Yale* A Broad Sta. 8. Victoria. John Cochrane. Yatea A Dou- Rlaa 8U.. 8. Victoria. Ferry's Drue Store. Fort A Douslaa HU.. 8. Victoria. W. W. Gardiner. Pandora A Cook 8M.. Victoria. W. Jackeon A Co.. 1603 Dou- Rlai St.. Victoria. 12 < 1.60 1.60 1 28 1 26 Vendon. 17 . 38S- m rnlihar imUhcr BR l.lNIlfSNT OF CAMPHUK InipKtor'i Report la nut Ml expr««lon opinlODi Rcaulla at Aiulytla III llfl Indax lA.sa MO C \ C a 9a Ramuki aod Opinion of tiM OhtaT Analyat O. ARMYTAOE. IN8FKCTUR. sa.o SAO 85 eo.A 76.0 I 31 SO 10.07 20.47 24.11 26.26 20.38 1.467S negative 75708 18.34 1.4730 podtlve 7S700 31. M 1.4680 negative 75710 33.82 1.4680 •• 75711 27.02 1.4680 75712 Oenulne. Genuine ai to Oampbor content : made wltb rotton aeed oil. Oenulne. Genuine. Genuine. )RIA-