key: cord-1053252-n073lje5 authors: Wacrenier, Samuel; Coindre, Jean Philippe; Blanchi, Sophie; Piccoli, Giorgina Barbara title: Cat on a hot tin roof (a nephrology zebra) date: 2021-04-23 journal: J Nephrol DOI: 10.1007/s40620-021-01052-8 sha: 4b9d7da71f32283c8a6485c69bac0c4640f15e89 doc_id: 1053252 cord_uid: n073lje5 nan On physical examination, he was asymptomatic (temperature 37.3 °C, blood pressure 136/84 mm Hg, pulse 65 beats per minute, respiratory rate 18 breaths per minute). There were no clinical signs of dehydration or hyperhydration. Greenish anal discharge was noted. There was no sign of other clinical infection and the remainder of the examination was normal. Abdominal ultrasound revealed a right kidney of 11 cm and a left kidney of 11.7 cm, without dilatation of the urinary tract, but with right calyceal lithiasis. Hepatitis C serology, HIV RNA viral load, Chlamydia trachomatis, Neisseria gonorrhoeae, Trichomonas vaginalis and Mycoplasma genitalium polymer chain reactions (PCR) on blood sample were all negative, as was SARS-COV 2 PCR on nasopharyngeal swab. The remaining biology is reported in Table 1 . This patient presented acute kidney injury of tubulo-interstitial profile with an increased creatinine phosphokinase (CPK) level, occurring in the setting of a festive evening a few days earlier, in a situation of psychological vulnerability. In this context, in the absence of infectious or autoimmune diseases, the first hypothesis is drug consumption, the recreational drug 3-methylmethcathinone, also known as 3-MMC, or "the 3" being the most likely candidate. After re-discussion, the patient admitted he had taken 3-MMC for the first time the previous week. 3-MMC is a recreational drug that belongs to the synthetic cathinone family [1] . The amphetamines formerly produced in plants, namely cathinone (khat) from the plant Catha edulis, were replaced in the 1990s by synthetic derivatives including 4-MMC (mephedrone), 4-MEC (4¬methylcathinone), MDPV (3,4¬methylenedioxypyrovalerone), and alpha-PVP. These substances, which were initially * Samuel Wacrenier sam.w@hotmail.fr 1 CH Le Mans: Centre Hospitalier du Mans, Le Mans, France considered harmless, were known as "legal highs" as their sale was not forbidden. The emergence of undesirable effects similar to those associated with conventional amphetamines [2] led to their being banned in the United States and several European countries, including France [3, 4] . Cathinones come in the form of powder, sometimes tablets, and can be ingested, injected or sniffed, the latter of which is the preferred route of administration due to low oral bioavailability [5] . They are among the most widely used products for chemsex (use of psychoactive products by male homosexuals) due to their stimulating, euphoric effect and increased sexual arousal [4, 6] . The adverse effects of cathinones are based on their direct toxicity, sometimes increased by environmental factors. After hepatic metabolism, the metabolites produced are deposited in target organs, including the kidneys, heart and lungs [3] . At the renal level, reported cases mainly show acute functional renal failure, ischemic acute tubular necrosis, acute interstitial nephritis or rhabdomyolysis, which can be severe enough to require dialysis [7, 8] . The drug may also produce hyperthermia (sometimes above 40 °C), diaphoresis, and renal vasoconstriction, which may combine with physical exertion in hot, unventilated environments, thus favouring AKI. Underlying chronic renal disease has been identified as a risk factor, which was the case for our patient [3] . 3-MMC, a structural isomer of 4-MMC, is thought to have stronger amphetamine-like stimulant properties through inhibition of the dopamine transporter [4] . Most descriptions of cathinone toxicity relate to 4-MMC, while 3-MMC has emerged more recently. In a Swedish study of 50 patients testing positive for 3-MMC, only two patients had severe rhabdomyolysis and only one presented with acute kidney injury. Eight of the patients had hyponatremia. These results need to take into consideration the fact that only 4 of the 50 patients had used 3-MMC alone, and therefore the effects described could have been caused by other drugs they had used [7] . 3-MMC is sold under a variety of labels: "research chemical", "bath salts" or "plant food". It is often referred to in the gay community as "drone", "bubble" or even "meow meow" ("miaou miaou" in French) [5, 8] in reference to the meowing of cats before their night-time frolics [9] . In our patient, AKI was attributed to a combination of rhabdomyolysis and pre-renal acute kidney injury/AKI on pre-existing CKD combined with 3-MMC use; while the patient did not clinically appear to be dehydrated, he received isotonic saline infusion, which corrected his kidney function. The anal discharge tested positive for Treponema pallidum, which was treated with BENETHAMINE BEN-ZYLPENICILLIN, 1.2 MIU in one injection. The patient was discharged 3 days after being admitted, upon attainment of his baseline creatinine level. The present case underlines the importance of considering illicit drug use in all cases of AKI, with particular attention to the new synthetic cathinone 3-MMC, whose emergence could lead to an increase in cases of acute renal failure similar to the one described herein. 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