key: cord-1048412-bu5phhkr
authors: Altunisik Toplu, Sibel; Ersoy, Yasemin; Bayindir, Yasar; Kilic, Talat; Bayazit, Volkan
title: Multisystem Inflammatory Syndrome in Adults (MIS-A) Associated with SARS-CoV-2 Infection in a Young Adult Case from Turkey
date: 2021-06-18
journal: Medeni Med J
DOI: 10.5222/mmj.2021.95422
sha: d4a865301c8ff9ee711e037b885d8e0cef4dd798
doc_id: 1048412
cord_uid: bu5phhkr

Weeks and even months after recovering from the SARS-CoV-2 infection, clinically more severe cases are being reported, which are suggestive of COVID-19- related multisystemic inflammatory syndromes (MIS). Firstly on March 2020, this condition was reported to be COVID-19 related to children (MIS-C). Since June 2020, a syndrome similar to multisystem inflammatory syndrome in adults (MIS-A) came to be noticed in adults as well. We reported here a case of 24-year-old young woman who had gone to a hospital with abdominal pain and later developed a severe cough, followed by development of subconjunctival bleeding, pericardial effusion, pleural effusion, and intra-abdominal fluid that we deemed them to be acute multisystemic clinical symptoms, 47 days after she had undergone a COVID-19 infection of mild clinical severity. It should be kept in mind that a multisystemic inflammatory syndrome along with a delayed immune response during COVID-19 disease can be seen not only in children but also in young adults, and seemingly severe clinical and laboratory findings can improve by controlling the inflammatory process.

. Centers for Disease Control and Prevention (CDC) brought together and published several adult case reports and series which have been recognized since June 2020 until now in The Morbidity and Mortality Weekly Report (MMWR) 1 . This new condition was reported first on March 2020 as a COVID-19 related MIS-C. Also, MIS-C was likened to Kawasaki disease (KD) [2] [3] [4] . MIS-C was published as a new disease that has clinical features as shock, cardiac dysfunction, abdominal ache, and elevation of inflammatory markers, which are C-reactive protein (CRP), ferritin, D-dimer, and interleukin 5 . KD is extremely rare in adults. On the other hand, after SARS-CoV-2 infection, severe course of COVID-19 clinic is less common in young adults and children. This syndrome, which was defined primarily in children in the late period after recovering from SARS-CoV-2 infection, can be seen especially in young adults.

A 24-year-old female patient without any known chronic disease presented with abdominal pain. It was learnt that the patient was diagnosed with COVID-19 infection 47 days ago but did not receive antiviral therapy. She tested for SARS-COV-2, but she had negative laboratory results for the disease. She was hospitalized after detection of 24 leukocytes/HPF in her complete urinalysis. On the second day of her hospitalization, severe headache and subconjunctival hemorrhage developed ( Figure 1 , the picture of the patient was shown with the approval of our patient) and also her body temperature was 38.9°C. The patient had sinus tachycardia. She had recurrent episodes of high fever despite medical interventions. Increased blood leukocyte counts and progressive lymphopenia were observed in her laboratory results. There were some more changes in her laboratory values (Table 1) . Pulmonary consolidation developed which had There was no growth in urine culture. The levels of acute phase reactants including C-reactive protein (CRP), procalcitonin (PCT), and interleukin-6 (IL-6) were normalized on the seventh day of hospitalization due to steroid treatment (Table 1) . Antibiotic treatment was stopped when the patient started feeling fine clinically. On the 13th day of hospitalization, the patient was discharged. Patient was using 32 mg steroid at the time of discharge. Her steroid dose tapered by 8 mg, and finally stopped. Treatment with ibuprofen tablet and colchicine continued for 10 days. Patient's blood chemistry results were within normal limits 50 days after her discharge. The patient's consent was obtained for the publication of this case report.

infection. On the other hand, a case definition was made for MIS-C seen in pediatric cases. The age range of the patients is between 0 and 21 years. Other diagnostic criteria were as follows: body temperature >38.0°C lasting more than 24 hours or family reporting the presence of fever; evidence of inflammation in laboratory tests (presence of at least two or more of the following laboratory criteria: increased CRP, PCT, D-dimer, IL-6, LDH levels, lymphopenia, and hypoalbuminemia), presenmce of a severe disease requiring hospitalization and multi-organ system involvement [the presence of at least two or more abnormal cardiovascular (e.g., shock, high troponin, high BNP, abnormal echo symptoms, and arrhythmia), respiratory (pneumonia, ARDS, and pulmonary embolism), renal (renal failure), neurological (convulsion, stroke, aseptic meningitis), hematological (coagulopathy, high D-dimer level), gastrointestinal (high liver enzymes, diarrhea and ileus), and dermatological findings (erythroderma, mucositis, and another rash), lack of any other alternative diagnosis (such as bacterial sepsis, myocarditis-related infections such as enterovirus infection, staphylococcal or streptococcal toxic shock syndromes), and evidence of past or recent SARS-CoV-2 infection (SARS-CoV-2 RT-PCR-positivity, SARS-CoV-2 serology positivity, SARS-CoV-2 antigen positivity, contact with an at least one SARS-CoV-2 positive case)] 6 . Our case was 24 years old but fulfilled most of the other criteria.

The pathological relation between MIS-C/MIS-A and SARS-CoV-2 has not been enlightened yet 5 . There is a report of a young adult woman from Belgium that indicated that this syndrome is a late immunity reaction against COVID-19 and the viral molecule cannot be demonstrated by molecular analyzes 7 . In our case, the patient's nasopharyngeal swab for SARS-CoV-2 came positive 47 days ago, but the disease was mild, and she did not use antiviral treatment. SARS-CoV-2 PCR tests of the patient who applied to the emergency service with abdominal pain and high fever two days after her admission, yielded negative results. Afterwards, subconjunctival hemorrhage, pleural and pericardial effusion, presence of free abdominal fluid, edema on the eyelid, clinical and radiological imaging made us think about hyperinflammatory reactions. Patient's COVID-19 (SARS-CoV-2) IgG level was detected as 3.19 and (index 0-1.4) IgM level as 1(index 0-1). Detection of SARS-CoV-2 specific antibodies supported our opinion.

Acute COVID-19 disease is related to hyperinflammatory disease; however, the late multisystemic inflammatory syndrome is different from acute COVID-19 hyperinflammation 5 . There are laboratory results suggesting hyperinflammation, without any evidence of shortness of breath. Besides that, extrapulmonary organ dysfunction could be severe. Cardiac symptoms, which include left ventricular heart failure, high troponin levels, but most commonly arrhythmias were reported 1 . In our case, rapidly elevated IL-6, PCT, CRP, ferritin, P-BNP, D-Dimer levels and pleural effusion, pericardial effusion, tachycardia (up to 150/bpm), and shortness of breath were seen in the first two days. On the fourth day of hospitalization, patient's Pro-BNP (NT-proBNP) level was 7795 pg/ mL (normal: 0-110 pg/mL). Increased brain natriuretic peptide (BNP) and ProB-type natriuretic peptide (NT-proBNP) levels have been demonstrated in cases with heart failure 8 . However, ejection fraction was 60% (normal: >53%) on echocardiogram on the fifth day of hospitalization.

Intravenous immunoglobulin, corticosteroids, IL-6 receptor inhibitor tocilizumab, and various antibiotherapies had been administered to the patients with MIS-A. Most of the patients recovered even they had clinically severe symptoms 1 . In a 25-year-old case reported from Atlanta (USA), the patient had recovered after treatment with intravenous immunoglobulin (IVIG), aspirin, and supportive care 9 . Clinical condition of our patient improved one day after she took steroid treatment. Her body temperature became normal. Due to cardiac findings, ibuprofen and colchicine were added to her prescription on the sixth day of hospitalization. Bacteria culture tests did not reveal any evidence supporting the presence of an infection. The patient was clinically recovered after seven days of steroid treatment. Laboratory tests were all within normal limits 50 days after her discharge.

The case definition for MIS-C was made by the Centers for Disease Control and Prevention (CDC) 6 . Similar clinical features can be seen in cases reported in adults; however, there have been a limited number of cases reported as MIS-A so far 1, 6, 9 . Clinicians should consider MIS-A in adults with coherent signs and symptoms of COVID-19. It is helpful to recognize and treat cases of MIS-A, based on mainly clinical suspicion and antibody testing for SARS-CoV-2. More data are needed to understand better the pathogenesis, risk factors, clinical-laboratory variables, and results of this newly described condition in order to guide the treatment.

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