key: cord-1046921-lxi6o21j
authors: Zhu, Feng; Cao, Yang; Xu, Shuyun; Zhou, Min
title: Co‐infection of SARS‐CoV‐2 and HIV in a patient in Wuhan city, China
date: 2020-03-11
journal: J Med Virol
DOI: 10.1002/jmv.25732
sha: d78ca5f97a6d30b545e4a3af253639df97838a34
doc_id: 1046921
cord_uid: lxi6o21j

nan

To the Editor, A pneumonia of unknown pathogen that emerged in China had its first case announced in early December 2019 within Wuhan City, the capital of Hubei Province and one of the busiest and populated Chinese cities. 1 The causative agent was identified as a novel coronavirus and named SARS-CoV-2. Patients infected by the SARS-CoV-2 showed symptoms of fever and dyspnoea, lymphopenia, and ground-glass lung changes in radiology. 2, 3 Severe cases developed life-threatening complications, such as respiratory failure, shock, and multiple organs dysfunction. 4 We report on an identified unique severe case involving co-infection of SARS-CoV-2 and HIV.

On 28 January 2020, a 61-years-old male from Hankou district of Wuhan reported recurrent fever and dry cough for 2 days went to a local fever clinic, which was setup for screening the SARS-CoV-2-infected and suspected subjects. The patient was a heavy smoker of between 20 to 30 cigarettes a day. He had also been diagnosed with type II diabetes 2 year ago and received alogliptin co-administered with metformin. The body temperature was 37.5°C. The clinic physician or- CoV-2 infection, was started on admission. 5 The patient also received moxifloxacin 400 mg once daily for 7 days, γ-globulin 400 mg/kg once daily for 3 days, and methilprednisolone 0.8 mg/kg once daily for 3 days through intravenous route. On 9 February, the patient showed a marked clinical and radiological improvement ( Figure 1C ). His oxygen saturation measured by pulse maintained above 95% on supplemental oxygen via nasal cannula at 2 liters per minute. Two additional throat swabs were obtained on 15 February and both were tested negative for SARS-CoV-2 RT-PCR assay. The patient was in stable condition and discharged on 17 February. He was asked to keep isolated at home for two more weeks.

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