key: cord-1046001-5bf3mzjs
authors: Sathyamoorthy, NandhaKumar; Kumar Chintamaneni, Pavan; Chinni, Santhivardhan
title: Plausible role of combination of Chlorpromazine hydrochloride and Teicoplanin against COVID-19
date: 2020-06-20
journal: Med Hypotheses
DOI: 10.1016/j.mehy.2020.110011
sha: dea6e07652b163808e674fde18095a3bb92a6f9e
doc_id: 1046001
cord_uid: 5bf3mzjs

[Figure: see text] Structure of COVID-19 Virus; Plausible role of combination of Chlorpromazine hydrochloride and Teicoplanin in controlling COVID-19 replication, where Chlorpromazine hydrochloride inhibiting binding of virus to Clathrin pits and Teicoplanin inhibiting inhibiting low pH cleavage of viral spike protein

To the editor COVID-19 is an endangering viral infection claiming lakhs of lives across the globe. The early spread of COVID-19

was reported from Wuhan, China in December 2019 (1), and was declared as pandemic on March 11, 2020 (2). 

The article has no funding source.

The authors declare no conflict of interest.

Pattern of early human-to-human transmission of Wuhan

Responding to COVID-19 pandemic: Why a strong health system is required

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and corona virus disease-2019 (COVID-19): the epidemic and the challenges

Coronavirus puts drug repurposing on the fast track

FDA approved drugs with broad anticoronaviral activity inhibit SARS-CoV-2 in vitro

Mis-assembly of clathrin lattices on endosomes reveals a regulatory switch for coated pit formation

Teicoplanin potently blocks the cell entry of 2019-nCoV, bioRxiv

Teicoplanin: an alternative drug for the treatment of coronavirus COVID-19

The authors of the current article entitled "Plausible role of combination of Chlorpromazine hydrochloride and Teicoplanin against COVID-19" declare that there are no conflicts of Interest