key: cord-1043513-54yiqdzw
authors: Izmailova, Elena S.; Reiss, Theodore F.
title: Closer to the Patient Means Better Decisions: Wearable Remote Monitoring of Patients with COVID‐19 Lung Disease
date: 2021-06-03
journal: Clin Transl Sci
DOI: 10.1111/cts.13085
sha: 9fe93eb40563168516ed7b3937b3c1d8ca34ea58
doc_id: 1043513
cord_uid: 54yiqdzw

Despite unprecedented achievements in vaccine development, COVID‐19 is likely to continue to be a threat to humans. While our knowledge of the lung pathology continues to accumulate, the functional impact remains poorly understood. Cohort studies with longitudinal clinic and home‐based monitoring of patients are needed. The most informative respiratory system assessments include: pulmonary function testing, oxygen saturation, and exercise challenge tests. The derived data will inform intervention trials and treatment guidelines for health care providers.

Despite unprecedented achievements in vaccine development, COVID-19 is likely to continue to be a threat to humans. While our knowledge of the lung pathology continues to accumulate, the functional impact remains poorly understood. Cohort studies with longitudinal clinic and home-based monitoring of patients are needed. The most informative respiratory system assessments include: pulmonary function testing, oxygen

This article is protected by copyright. All rights reserved saturation, and exercise challenge tests. The derived data will inform intervention trials and treatment guidelines for health care providers.

Despite unprecedented achievements in vaccine development, the emergence of novel SARS-COV-2 variants with increased transmissibility and "immune escape" properties, coupled with vaccine hesitancy and less than optimal compliance with public health measures, suggests that COVID -19 is likely to continue to be a threat to humans, at least in the near term. Clinically, these observations translate into the possibility that a significant number of COVID-19 illnesses are likely to remain an unfortunate reality 1 . Recent increasing infection trends in a number of countries worldwide remind us of this potential risk.

This unfortunate possibility requires us to continue to expand our understanding of this disease. We must widen our lenses to understand now more fully both the natural history and the long-term consequences of

This article is protected by copyright. All rights reserved COVID-19 illness, especially severe illness, on survivors of this infection. Neither of these has been well studied thus far. The long-term sequelae of COVID-19 is multifaceted and involves both neurological and neuropsychiatric symptoms, including depression and impaired cognitive function 2 , as well as altered lung function 3 . Both sets of conditions present different but formidable challenges in terms of long-term follow-up and patient care. The focus of this commentary is monitoring for impaired lung function.

Presently available data suggests that significant numbers of patients surviving acute, severe infection have persistent respiratory symptoms and signs requiring appropriate monitoring 4 . Because the natural history of these symptomatic patients has not been well established, the long-term consequences of respiratory damage has not been adequately described. What is clear is that virus infection results in injury to the alveolar tissues (including blood vessels) resulting in interstitial tissue inflammation, ventilation perfusion (V/Q) mismatching and impaired oxygenation. 5 Available information suggests that these injuries, in many cases, can result in a form of pulmonary interstitial fibrosis potentially leading to persistent symptoms of dyspnea, cough, and fatigue. 6 While radiologic documentation of these pathologic effects in the lung continues to accumulate, 7 our understanding of the long-term functional impact remains limited. Barriers to a more robust understanding of the course of this disease include larger and more widespread community-based cohort studies that allow for both sufficient longitudinal clinic and home-based monitoring of patients. These efforts will provide data to support adequate intervention trials, and subsequent diagnostic and treatment guidelines for health care providers. The need for these community-based trials requires that home-based monitoring takes an important role in monitoring and data collection. A comprehensive approach for patient remote monitoring in clinical trials was described by Dockendorf et al. 8 which includes outpatient specimen collection, use of digital devices to collect and measure physiological and behavioral data as well as integration of digital data streams and data visualization. Transitioning of clinic measurements to remote settings has been in a spotlight during the pandemic; however, many assessments are still under development and require validation studies 9 .

A recent review of studies assessing lung function in acutely ill COVID patients indicated that the most pronounced change is the diminished diffusion capacity of the lungs for carbon monoxide (DLCO), followed by changes in mechanical parameters such as forced vital capacity (FVC) and forced expiratory volume in one second (FEV1). The data from the studies included in the review did not reach a firm conclusion about

This article is protected by copyright. All rights reserved obstructive versus restrictive patterns in lung tissue changes, due to variability in study design and relatively small numbers of patients included. 3 These preliminary data highlight the need for close longitudinal follow up of these patients to understand natural history, disease progression/resolution and subsequent appropriate intervention and treatment.

The practical aspects of clinical measurements are of paramount importance for selection and deployment for research and clinical decision-making. For example, DLCO is an informative parameter, but it requires sophisticated equipment and can be done only during clinic visits, while other PFT parameters, like FVC and FEV1, can be performed remotely by means of mobile spirometry which were demonstrated to be equivalent to clinic measures in a pilot study 10 . Recent guidance from the American Thoracic Society indicates that athome spirometry collection (FEV1 and FVC) can be a viable alternative to in-clinic spirometry tests, though caution remains about remote test accuracy as data continues to accumulate about its measurement properties, of which initial reports appear to be favorable. 11 Consistent with the DLCO data, impaired arterial oxygenation, as measured by pulse oximetry, has been shown to be an important prognostic factor for worse outcomes during the acute phase of COVID-19 illness. 12 Based on these observations, the use of oximetry is suggested for follow-ups during the recovery period.

(drop in arterial pO2) with exercise, and evidence suggests that normal pulse oximetry values taken at rest may deteriorate with physical exertion in the presence V/Q abnormalities which are present in COVID illness, exertion induced desaturation may be a marker of persistent disease. 13 Several exertional tests for measuring oxygen desaturation in post-COVID-19 patients are safe and easy to perform at home, such as the 1-minute sit-to-stand test and the 40-step test. These tests are less well characterized compared to the more conventional 6-minute walk test (6MWT) but are very practical for in-home conditions and in frail patients. 13 Therefore, available data suggests that the three categories of assessments most useful in characterizing the natural history of COVID-19 illness in the respiratory system include: pulmonary function test (PFT), capillary blood oxygen saturation (SpO2), and exercise challenge tests. These measurements are all capable of being measured in the community setting and at home.

From a clinical point of view, the utility of wearable devices and home based "remote" patient monitoring was recognized in the early days of the coronavirus pandemic. In the absence of readily available SARS-COV-2

This article is protected by copyright. All rights reserved PCR tests, monitoring for vital signs via devices such as digital thermometers and pulse oximeters provided a viable opportunity for monitoring patients and triaging the need for immediate intervention.

Today, remote monitoring of vital signs and symptoms during the acute phase of COVID-19 is commonplace and well characterized. The combination of self-reported symptoms and data from wearable monitors provide a relatively accurate method of detecting symptomatic infections. Notably, the DETECT study, run by the Scripps Research Institute, provides an algorithm to predict COVID-19 based on data collected by fitness trackers 14 .

Considering the large number of symptomatic survivors of COVID-19 illness, identifying tools and instruments that can be deployed remotely, conveniently and with the patient at home (Table 1 ) may help monitor patients suffering from a slow or incomplete recovery or those worsening over time 3 . However, several barriers need to be removed to make remote patient monitoring a reality. These barriers include technological challenges: not all clinic assessments can be transitioned to a remote mode and a comprehensive monitoring package should include both clinic and at home measures ( Figure 1) . The abovementioned example of DLCO requires an in clinic assessment while other pulmonary function parameters, like FVC and FEV1, can be collected remotely 10 (Table 1 ). The biotech/pharmaceutical industry as well as the healthcare and regulatory communities need to get comfortable with this approach. These measurements need to be validated in remote settings prior to a wide deployment to understand its measurement properties 9 . Moreover, healthcare providers may need the demonstration of the outcome benefits of this approach. Changes for remote monitoring reimbursement were introduced during the pandemic but remain authorized only for the duration of COVID-19 health emergency 15 . Remote patient monitoring might give an answer to the numerous questions about the natural history of this illness, choice of sensitive and specific measurement tools, and frequency of monitoring. In addition to defining the natural history of this illness, these remote measurement tools can be put to work monitoring disease and evaluating therapeutic interventions to mitigate the morbidity and mortality effects of this ongoing virus pandemic. 

Neurological and neuropsychiatric complications of COVID-19 in 153 patients: a UK-wide surveillance study

Respiratory function in patients post-infection by COVID-19: a systematic review and meta-analysis

Lung function testing in the COVID-19 endemic

The pathophysiology of 'happy' hypoxemia in COVID-19

A Clinic Blueprint for Post-Coronavirus Disease 2019 RECOVERY: Learning From the Past, Looking to the Future

High Prevalence of Pulmonary Sequelae at 3 Months after Hospital Discharge in Mechanically Ventilated Survivors of COVID-19

Digitally Enabled, Patient-Centric Clinical Trials: Shifting the Drug Development Paradigm

Remote FEV1 Monitoring in Asthma Patients: A Pilot Study

Restoring Pulmonary and Sleep Services as the COVID-19 Pandemic Lessens. From an Association of Pulmonary, Critical Care, and Sleep Division Directors and

Factors associated with hospitalization and critical illness among 4,103 patients with Covid-19 disease in New York City. medRxiv

All rights reserved 13. University of Oxford the center for evidence-based medicine

Wearable sensor data and self-reported symptoms for COVID-19 detection

How to make remote monitoring Part of everyday healthcare, Harvard business review

This article is protected by copyright. All rights reserved