key: cord-1036978-uxcdscl9
authors: Crovetto, F.; Pascal, R.; Casas, I.; Cahuana, A.; Sola, M. Larroya; Camacho, M.; Valle, M. Tortajada; Youssef, L.; Arranz, A.; Crispi, F.; Gomez‐Roig, M.; Gratacos, E.
title: VP31.02: Mental wellbeing in pregnant women during SARS‐CoV‐2 pandemic
date: 2021-10-14
journal: Ultrasound Obstet Gynecol
DOI: 10.1002/uog.24467
sha: 3be1a5b9929d1f8481547a7e10f1f074dbe89e29
doc_id: 1036978
cord_uid: uxcdscl9

nan

Objectives: On 11th March 2020, COVID-19 was declared a pandemic by the World Health Organization (WHO). As a result, many countries entered harsh lockdowns in order to restrict the spread of the virus. Several studies were conducted to assess the implication of the lockdowns on the rates of preterm birth, stillbirths and other maternal and perinatal outcomes, with inconsistent results. We have conducted a systematic review to report the current evidence of the Indirect impacts of COVID-19 on rates of preterm birth and perinatal mortality & morbidity. Methods: We conducted a systematic review following the PRISMA guidelines. We searched electronic databases MEDLINE, Embase, PubMed for potentially relevant published and preprint studies. Two independent reviewers conducted title/abstract screening, full text screening, and data extraction using a pre-specified form. Conflicts were resolved by consensus or consultation with a third reviewer. The primary outcome was the rate of preterm births following the introduction of the COVID-19 restrictions, compared to the rate before these restrictions. Secondary outcomes included stillbirth and neonatal death rates, neonatal birthweight, NICU admissions and rates of Caesarean deliveries. We have excluded studies assessing the direct effect of COVID-19. Results: Our initial search has retrieved a total of 485 studies, of which 20 met inclusion criteria after screening. We didn't find a statistically significant change in the rates of preterm births (OR 0.95 [0.88-1.02]) or stillbirths (OR 0.91 [0.76-1.09]). Conclusions: COVID-19 mitigation policies vary between regions which may have led to the inconsistencies in the reported effects on preterm birth and perinatal mortality across studies. It is vital to interrogate these differences to identify risk factors for preterm birth that may be potentially modifiable at the patient (reduced exposure to infection/inflammation), clinician (decision making) and societal levels (public health measures) to enable new strategies to prevent preterm birth in non-pandemic times. Objectives: To determine the effect of SARS-CoV-2 pandemic on maternal mental well-being during pregnancy and its related factors. Methods: A multicentric, prospective, population-based study (n = 1,320) including pregnant women consecutively attended during SARS-CoV-2 pandemic in Barcelona, Spain (March-June 2020). SARS-CoV-2 antibodies were measured in all participants and nasopharyngeal RT-PCR was performed at delivery to assess SARS-CoV-2 infection status. In addition, a previous pre-pandemic cohort (n = 345), matched by baseline maternal characteristics with the pandemic cohort, was used for comparison. Maternal mental well-being was assessed using the validated World Health Organization Well-Being Index (WHO-5). Women were classified as having a low (WHO-5 £52) or high (WHO-5 > 52) mental well-being. Results: In comparison with the pre-pandemic cohort, pregnant women attended during COVID-19 pandemic showed a worst WHO-5 well-being score (median pandemic cohort 56 [IQR 36-72] vs pre-pandemic 64 [IQR 52-76], p < 0.001), with a 42.8% of women presenting a low a mental well-being score vs 28% pre-pandemic (p < 0.001). At multivariate analysis, significant contribution to a low maternal mental well-being during COVID-19 pandemic were provided by the presence of a previous psychiatric disorder (OR 6.8; 95% CI 2.5-18.5, p < 0.001), being in the third trimester of pregnancy (OR 1.7; 95% CI 1.5-1.9, p < 0.001) or requiring hospital admission for COVID-19 (OR 6.8; 95% CI 1.5-18, p = 0.011). The infection for SARS-CoV-2, which affected 202 women (15.3%), was not associated with a lower mental well-being score. Conclusions: COVID-19 pandemic was associated with high rates of poor maternal mental well-being of pregnant women, particularly in those in the third trimester of pregnancy. However, not the infection of SARS-CoV-2 itself but other factors, such as previous psychiatric disorders, being at third trimester or hospital admission, were determinants for the lowest mental well-being condition.

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Josep Carreras Leukemia Research Institute