key: cord-1033811-ryzd57k1
authors: Fidalgo, Pedro; Veríssimo, Rita; Cardoso, Filipe S
title: Chronic kidney disease is associated with worse outcomes following SARS-CoV2 infection among 18647 patients: a population-based cohort study
date: 2021-01-23
journal: Nefrologia
DOI: 10.1016/j.nefro.2020.11.004
sha: f7167c57537f73be080787f83f48e6183ee76134
doc_id: 1033811
cord_uid: ryzd57k1

nan

Chronic kidney disease is associated with worse outcomes following SARS-CoV2 infection among 18647 patients: a population-based cohort study La enfermedad renal crónica se asocia con peores resultados después de la infección por SARS CoV2 entre 18647 pacientes: estudio de cohorte basado en la población The clinical spectrum of COVID-19 ranges from asymptomatic cases to those who develop acuterespiratory distress syndrome and require intensive care unit (ICU) admission [1, 2] .

Previous studies have identified chronic kidney disease (CKD) as a risk factor for severe outcomes following SARS-CoV2 infection [3] . This observation derives from data from small cohorts of hospitalized patients mainly from China [4] [5] [6] [7] and a UK cross-sectional survey describing 16749 patients hospitalized with COVID-19 [8] . Recently, the largest nationwide cohort study describing the impact of clinical risk factors on COVID-19 related deaths has been published and reports the negative impact of CKD on mortality among an unselected population of cases with COVID-19 [9] . Whether the same association is observed among non-hospitalized patients from different regions is yet to be confirmed. We aimed to determine the modifying impact of CKD Overall, 18647 cases were included in our analyses, following exclusion of 1623 (8.0%) cases without hospital admission status and 23 (0.1%) cases without outcome status. Among all cases, median (IQR) age was 50 (36-66) years (Table 1) . Male sex accounted for 7701 (41.3%) of all cases. While 15651 (83.9%) cases did not have any comorbidity, the remainder of cases had the following number of comorbidities: one in 2213 (11.9%) cases, 2 in 600 (3.2%) cases, and ≥3 in

Clinical course and risk factors for mortality of adult in cases with COVID-19 in Wuhan, China: a retrospective cohort study

Clinical Characteristics of Coronavirus Disease

Chronic kidney disease is associated with severe coronavirus disease 2019 (COVID-19) infection

Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury

Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China

Clinical characteristics of 140 patients infected with SARS-CoV-2 in Wuhan, China

Kidney disease is associated with in-hospital death of patients with COVID-19

Features of 16,749 hospitalised UK patients with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol

OpenSAFELY: factors associated with COVID-19 death in 17 million patients

Age, sex, and comorbidities predict ICU admission or mortality in cases with SARS-CoV2 infection: a population-based cohort study

The authors have no conflicts of interest to declare.The results presented in this paper have not been published previously in whole or part.