key: cord-1031038-rpjg4a9i
authors: Delahoy, Miranda J.; Ujamaa, Dawud; Whitaker, Michael; O'Halloran, Alissa; Anglin, Onika; Burns, Erin; Cummings, Charisse; Holstein, Rachel; Kambhampati, Anita K.; Milucky, Jennifer; Patel, Kadam; Pham, Huong; Taylor, Christopher A.; Chai, Shua J.; Reingold, Arthur; Alden, Nisha B.; Kawasaki, Breanna; Meek, James; Yousey-Hindes, Kimberly; Anderson, Evan J.; Openo, Kyle P.; Teno, Kenzie; Weigel, Andy; Kim, Sue; Leegwater, Lauren; Bye, Erica; Como-Sabetti, Kathryn; Ropp, Susan; Rudin, Dominic; Muse, Alison; Spina, Nancy; Bennett, Nancy M.; Popham, Kevin; Billing, Laurie M.; Shiltz, Eli; Sutton, Melissa; Thomas, Ann; Schaffner, William; Talbot, H. Keipp; Crossland, Melanie T.; McCaffrey, Keegan; Hall, Aron J.; Fry, Alicia M.; McMorrow, Meredith; Reed, Carrie; Garg, Shikha; Havers, Fiona P.; Kirley, Pam Daily; McLafferty, Sarah; Armistead, Isaac; Fawcett, Emily; Ward, Katelyn; Lynfield, Ruth; Danila, Richard; Khanlian, Sarah; Angeles, Kathy; Engesser, Kerianne; Rowe, Adam; Felsen, Christina; Bushey, Sophrena; Abdullah, Nasreen; West, Nicole; Markus, Tiffanie; Hill, Mary; George, Andrea
title: Hospitalizations Associated with COVID-19 Among Children and Adolescents — COVID-NET, 14 States, March 1, 2020–August 14, 2021
date: 2021-09-10
journal: MMWR Morb Mortal Wkly Rep
DOI: 10.15585/mmwr.mm7036e2
sha: b6e8ffe67156304222bcce771b781e1a3b044765
doc_id: 1031038
cord_uid: rpjg4a9i

Although COVID-19-associated hospitalizations and deaths have occurred more frequently in adults,† COVID-19 can also lead to severe outcomes in children and adolescents (1,2). Schools are opening for in-person learning, and many prekindergarten children are returning to early care and education programs during a time when the number of COVID-19 cases caused by the highly transmissible B.1.617.2 (Delta) variant of SARS-CoV-2, the virus that causes COVID-19, is increasing.§ Therefore, it is important to monitor indicators of severe COVID-19 among children and adolescents. This analysis uses Coronavirus Disease 2019-Associated Hospitalization Surveillance Network (COVID-NET)¶ data to describe COVID-19-associated hospitalizations among U.S. children and adolescents aged 0-17 years. During March 1, 2020-August 14, 2021, the cumulative incidence of COVID-19-associated hospitalizations was 49.7 per 100,000 children and adolescents. The weekly COVID-19-associated hospitalization rate per 100,000 children and adolescents during the week ending August 14, 2021 (1.4) was nearly five times the rate during the week ending June 26, 2021 (0.3); among children aged 0-4 years, the weekly hospitalization rate during the week ending August 14, 2021, was nearly 10 times that during the week ending June 26, 2021.** During June 20-July 31, 2021, the hospitalization rate among unvaccinated adolescents (aged 12-17 years) was 10.1 times higher than that among fully vaccinated adolescents. Among all hospitalized children and adolescents with COVID-19, the proportions with indicators of severe disease (such as intensive care unit [ICU] admission) after the Delta variant became predominant (June 20-July 31, 2021) were similar to those earlier in the pandemic (March 1, 2020-June 19, 2021). Implementation of preventive measures to reduce transmission and severe outcomes in children is critical, including vaccination of eligible persons, universal mask wearing in schools, recommended mask wearing by persons aged ≥2 years in other indoor public spaces and child care centers,†† and quarantining as recommended after exposure to persons with COVID-19.§§.

with indicators of severe disease (such as intensive care unit [ICU] admission) after the Delta variant became predominant (June 20-July 31, 2021) were similar to those earlier in the pandemic (March 1, 2020-June 19, 2021). Implementation of preventive measures to reduce transmission and severe outcomes in children is critical, including vaccination of eligible persons, universal mask wearing in schools, recommended mask wearing by persons aged ≥2 years in other indoor public spaces and child care centers, † † and quarantining as recommended after exposure to persons with COVID-19. § § COVID-NET conducts population-based surveillance for laboratory-confirmed COVID-19-associated hospitalizations in 99 counties across 14 states ¶ ¶ (1) . Residents of the surveillance catchment area who received positive molecular or rapid antigen detection test results for SARS-CoV-2 during hospitalization or within 14 days before admission were classified as having COVID-19-associated hospitalizations. Unadjusted age-specific cumulative and weekly COVID-19associated hospitalization rates (hospitalizations per 100,000 children and adolescents residing in the catchment area) during March 1, 2020-August 14, 2021, were calculated by dividing the total number of hospitalized patients by the National Center for Health Statistics' population estimates within each age group for the counties included in the surveillance catchment area.*** Among adolescents, who are currently eligible for vaccination † were defined as those who had received a second vaccine dose ≥14 days before a positive SARS-CoV-2 test result associated with their hospitalization. Adolescents whose positive SARS-CoV-2 test date was ≥14 days after a single dose through <14 days after a second dose were considered partially vaccinated and were not included in rates; adolescents who had received a single dose of vaccine <14 days before the positive SARS-CoV-2 test result were also not included in rates If the SARS-CoV-2 test date was not available, hospital admission date was used. Adolescents whose vaccination status had not yet been verified using the immunization information system data were considered to having missing vaccination status and were excluded. Adolescents whose vaccination status was checked against the immunization information system and who did not have documented receipt of any vaccine dose before the test date were considered unvaccinated. Additional COVID-NET methods for determining vaccination status have been described previously. https://medrxiv.org/cgi/ content/short/2021.08.27.21262356v1 **** https://covid.cdc.gov/covid-data-tracker/#variant-proportions was defined as p<0.05. This activity was reviewed by CDC and was conducted consistent with applicable federal law and CDC policy. † † † † During March 1, 2020-August 14, 2021, COVID-NET identified 49.7 cumulative COVID-19-associated hospitalizations per 100,000 children and adolescents ( Figure 1 ); rates were highest among children aged 0-4 years (69.2) and adolescents aged 12-17 years (63.7) and lowest among children aged 5-11 years (24.0). Weekly hospitalization rates were at their lowest in 2021 during the weeks ending June 12-July 3 (0.3 per 100,000 children and adolescents each week) (Figure 2 ). During a subsequent 6-week period after the Delta variant became predominant, rates rose each week to 1.4 during the week ending August 14, 2021, which was 4.7 times the rate during the week ending June 26, 2021 and approached the peak hospitalization rate of 1.5 observed during the week ending January 9, 2021. § § § § Weekly rates increased among all age groups; the sharpest increase occurred among children aged 0-4 years, for whom the rate during the week ending August 14, 2021 (1.9) was nearly 10 times that during the week ending June 26, 2021 (0.2). During June 20-July 31, 2021, among 68 adolescents hospitalized with COVID-19 whose vaccination status had been ascertained, 59 were unvaccinated, five were partially vaccinated, and four were fully vaccinated; the hospitalization rate among unvaccinated adolescents was 0.8 per 100,000 person-weeks (95% CI = 0.6-0.9), compared with 0.1 (95% CI = 0.0-0.1) in fully vaccinated adolescents (rate ratio = 10.1; 95% CI = 3.7-27.9).

Among 3,116 hospitalized children and adolescents with COVID-19 during March 1, 2020-June 19, 2021, for whom complete clinical data were available, ¶ ¶ ¶ ¶ 827 (26.5%) were admitted to an ICU, 190 (6.1%) required IMV, and 21 (0.7%) died. Among 164 hospitalized children and adolescents with COVID-19 during June 20-July 31, 2021, for whom complete clinical data were available,***** 38 (23.2%) were admitted to † † † † 45 C. Figure 2 ; however, raw (nonaveraged) age-specific weekly rates are used in the text of the report. The smoothed 3-week running average rate of COVID-19-associated hospitalizations during the week ending January 9, 2021 (displayed in Figure 2 an ICU, 16 (9.8%) required IMV, and three (1.8%) died. The differences in these indicators of severe disease between the two periods were not statistically significant (Table) .

Weekly COVID-19-associated hospitalization rates rose rapidly during late June to mid-August 2021 among U.S. children and adolescents aged 0-17 years; by mid-August, the rate among children aged 0-4 years was nearly 10 times the rate 7 weeks earlier. This increase coincides with widespread circulation of the highly transmissible Delta variant. COVID-NET data indicate that vaccination was highly effective in preventing COVID-19-associated hospitalizations in adolescents during late June to late July 2021. Since March 2020, approximately one in four hospitalized children and adolescents with COVID-19 has required intensive care, although the proportions with indicators of severe disease during the period when the Delta variant predominated were generally similar compared with those earlier in the pandemic. The observed indicators of severe COVID-19 among children and adolescents, as well as the potential for serious longer-term sequelae (e.g., multisystem inflammatory syndrome in children) documented elsewhere (5, 6) , underscore the importance of implementing multipronged preventive measures to reduce severe COVID-19 disease, including nonpharmaceutical interventions and vaccination among eligible age groups. † † † † † Among adolescents aged 12-17 years, the only pediatric age group for whom a COVID-19 vaccine is currently approved, hospitalization rates were approximately 10 times higher in unvaccinated compared with fully vaccinated adolescents, indicating that vaccines were highly effective at preventing serious COVID-19 illness in this age group during a period when the Delta variant predominated. As of July 31, 2021, 32% of U.S. adolescents had completed a COVID-19 vaccination series (7); increasing vaccination coverage among adolescents, as well as expanding eligibility for COVID-19 vaccination to younger age groups if approved and recommended, is expected to reduce severe COVID-19-associated outcomes among children and adolescents.

Similar to another recent analysis, COVID-NET data suggest that indicators of severe disease among hospitalized children during an early period when the Delta variant predominated were generally similar to those observed earlier in the pandemic (8) . Trends in outcomes will need to be monitored closely as more data become available. For example, whereas the point estimate of the proportion of hospitalized children who required IMV during the period of Delta predominance (9.8%) was higher than that earlier in the pandemic (6.1%), the comparison of these proportions was based on a relatively small number of children (16) requiring IMV during the period of Delta predominance, and the difference was not statistically significant (p = 0.06). Further, surveillance data limited to hospitalized persons cannot be used to assess whether increases in COVID-19-associated hospitalization rates among children and adolescents are due to increased community SARS-CoV-2 transmission or increased disease severity caused by the Delta variant.

The findings in this report are subject to at least five limitations. First, children and adolescents meeting COVID-NET criteria with a positive SARS-CoV-2 test result might have been hospitalized primarily for reasons other than COVID-19 (2), resulting in potential overestimations of hospitalization rates. Second, COVID-19-associated hospitalizations might have been missed because of testing practices and test availability. Third, the number of hospitalized children with severe outcomes was small during June 20-July 31, 2021, limiting comparisons between periods before and during Delta variant predominance. Fourth, the number of fully vaccinated hospitalized adolescents remained low at the time of reporting, and hospitalization rates stratified by vaccination status are subject to error if misclassification of vaccination status occurred. Finally, the COVID-NET catchment areas include approximately 10% of the U.S. population; thus, findings might not be nationally generalizable.

Rates of COVID-19-associated hospitalization among children and adolescents increased rapidly from late June to mid-August 2021, coinciding with predominance of the Delta variant. With more activities resuming, including in-person school attendance and a return of younger children to congregate child care settings, preventive measures to reduce the incidence of severe COVID-19 are critical. Universal indoor masking is recommended for all teachers, staff members, students, and visitors in kindergarten through grade 12 schools, regardless of vaccination status. § § § § § CDC recommends that persons aged ≥2 years who are unvaccinated, as well as vaccinated persons in areas of substantial or high transmission, wear masks in all indoor public spaces. ¶ ¶ ¶ ¶ ¶ CDC also recommends that child care centers serving children too young to be vaccinated consider implementing § § § § § https://www.cdc.gov/coronavirus/2019-ncov/community/schoolschildcare/k-12-guidance.html ¶ ¶ ¶ ¶ ¶ https://www.cdc.gov/coronavirus/2019-ncov/vaccines/fully-vaccinated. html , vasopressor support, and disposition discharge (i.e., discharged alive or died in-hospital). § Medians were compared using a Wilcoxon rank sum test. Proportions were compared using chi square tests. The proportions who died during hospitalization were compared using Fisher's exact test. ¶ Highest level of respiratory support for each patient that needed respiratory support.

universal indoor masking for persons aged ≥2 years.****** All persons who are eligible should receive COVID-19 vaccines to reduce the risk for severe disease for themselves and others with whom they come into contact, including children who are currently too young to be vaccinated.

What is already known about this topic?

COVID-19 can cause severe illness in children and adolescents.

What is added by this report?

Weekly COVID-19-associated hospitalization rates among children and adolescents rose nearly five-fold during late June-mid-August 2021, coinciding with increased circulation of the highly transmissible SARS-CoV-2 Delta variant. The proportions of hospitalized children and adolescents with severe disease were similar before and during the period of Delta predominance. Hospitalization rates were 10 times higher among unvaccinated than among fully vaccinated adolescents.

What are the implications for public health practice?

Preventive measures to reduce transmission and severe outcomes in children and adolescents are critical, including vaccination, universal masking in schools, and masking by persons aged ≥2 years in other indoor public spaces and child care centers.

CDC COVID-19 Response Team; 2 Epidemic Intelligence

Iowa Department of Health; 13 Michigan Department of Health and Human Services; 14 Minnesota Department of Health; 15 New Mexico Emerging Infections Program

20 Ohio Department of Health; 21 Public Health Division, Oregon Health Authority

COVID-NET Surveillance Team. Hospitalization rates and characteristics of children aged <18 years hospitalized with laboratory-confirmed COVID-19-COVID-NET, 14 states

COVID-NET Surveillance Team. Hospitalization of adolescents aged 12-17 years with laboratoryconfirmed COVID-19-COVID-NET, 14 states

The Advisory Committee on Immunization Practices' interim recommendation for use of Pfizer-BioNTech COVID-19 vaccine in adolescents aged 12-15 years-United States

Effectiveness of Pfizer-BioNTech and Moderna vaccines in preventing SARS-CoV-2 infection among nursing home residents before and during widespread circulation of the SARS-CoV-2 B.1.617.2 (Delta) variant-National Healthcare Safety Network

Preliminary evidence on long COVID in children

Multisystem inflammatory syndrome in U.S. children and adolescents

COVID-19 vaccination coverage among adolescents aged 12-17 years-United States

Trends in COVID-19 cases, emergency department visits, and hospital admissions among children and adolescents aged 0-17 years-United States

Brooke Heidenga, Joelle Nadle, Susan Brooks, Alison Ryan, All authors have completed and submitted the International Committee of Medical Journal Editors form for disclosure of potential conflicts of interest. William Schaffner reports consultant fees from VBI Vaccines, outside the submitted work. Eli Shiltz and Laurie M. Billing report grant funding from the Council of State and Territorial Epidemiologists (CSTE) for the populationbased Influenza Hospitalization Surveillance Project (IHSP) and COVID-NET activities. Lauren Leegwater and Sue Kim report grant support from CSTE through the Michigan Department of Health and Human Services. Andy Weigel and Kenzie Teno report grant support from CSTE for data collection and participation in ongoing meetings related to COVID-19 hospitalization surveillance. Evan J. Anderson reports grants for clinical trials from Pfizer, Merck, PaxVax, Micron, Sanofi-Pasteur, Janssen, MedImmune, and GSK; consulting fees from Sanofi-Pasteur, Pfizer, Janssen, and Medscape; personal fees for data safety monitoring board participation from Kentucky Bioprocessing, Inc. and Sanofi-Pasteur; and institutional funding from the National Institutes of Health to conduct clinical trials of Moderna and Janssen COVID-19 vaccines. No other potential conflicts of interest were disclosed.