key: cord-1030031-11vruj5l authors: González Ruiz, Francisco Javier; Lazcano Díaz, Emmanuel Adrián; López Reyes, Julio Cesar; Rojas Velasco, Gustavo; Baranda Tovar, Francisco Martín; Bucio Reta, Eduardo title: Woman with cough and shortness of breath date: 2020-12-26 journal: J Am Coll Emerg Physicians Open DOI: 10.1002/emp2.12339 sha: 054ce40c289a1ced140b742eb70660f15fb8483c doc_id: 1030031 cord_uid: 11vruj5l nan A 47-year-old woman with a history of being overweight was admit- It is well known that SARS-CoV-2 is mainly spread from person to person via respiratory droplet transmission. The virus that is received via respiratory aerosols binds mainly to the nasal epithelial cells. 1 There is evidence that SARS-CoV-2 entry in the cells depends on the angiotensin-converting enzyme 2 receptor, which is seen to be highly expressed in adult upper respiratory tract epithelial cells. 2, 3 Once COVID-19: current understanding of its pathophysiology, clinical presentation and treatment Receptor recognition by the novel coronavirus from Wuhan: an analysis based on decade-long structural studies of SARS coronavirus SARS-Cov-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor Severe acute respiratory syndrome coronavirus infection of human ciliated airway epithelia: role of ciliated cells in viral spread in the conducting airways of the lungs