key: cord-1028152-p56hhyw5 authors: Natalucci, Valentina; Lucertini, Francesco; Vallorani, Luciana; Brandi, Giorgio; Marchegiani, Manuela; Pistelli, Mirco; Berardi, Rossana; Ceravolo, Maria Gabriella; Barbieri, Elena; Capecci, Marianna title: A Mixed-apprOach program To help women wIth breast cancer stay actiVE (MOTIVE program): A pilot-controlled study date: 2021-10-27 journal: Heliyon DOI: 10.1016/j.heliyon.2021.e08252 sha: 0d0567e954e86a4439863b9c2ef91fc3e70e43ac doc_id: 1028152 cord_uid: p56hhyw5 Given the benefits of physical activity for breast cancer survivals, this pilot study aims to assess the feasibility of the MOTIVE program at achieving and maintaining the recommended physical activity level in women diagnosed and treated breast cancer, over 16 weeks. We conduct a pilot-controlled study of 20 women diagnosed with breast cancer stage I, II or IIIa. In this study, women of Intervention Arm (n = 10) received the MOTIVE program. This group was compared to women of Control Arm (n = 10) who received only counselling. Health-related fitness measures, and quality of life were assessed at baseline (t0) and after 4 (t1), 8 (t2) and 16 (t3) weeks. Intervention Arm women reached the recommended physical activity guidelines at t1 and t2 (eff.size = 1.9 [1.0–3.1]), and 90% continued to be active, autonomously, at t3 (eff.size = 1.12 [0.21–2.12]). Intervention Arm participants’ arm strength, fitness levels and quality of life also improved over time. No significant improvements in outcome measures were observed in Control Arm participants. These results are encouraging and suggest that the MOTIVE program may be a viable, well tolerated and effective option to help breast cancer women reaching a stable physical activity level over time, which meets prevention-related goals. Breast cancer (BC) patients adopting a healthy lifestyle after treatment may improve their disease-free survival rate [1, 2] and health-related outcomes [3] . Although current evidence is not strong enough to make specific recommendations for breast cancer survivors (BCSs) [4] , reports are growing on the improvements and potential beneficial effects induced by change in modifiable lifestyle behaviors, such as nutrition and physical activity [5, 6, 7, 8, 9, 10, 11] . In particular, increasing physical activity (PA), due to its positive impact on body weight, physical fitness, fatigue, depressive symptoms, anxiety, inflammatory profile and quality of life [5, 6, 7, 8, 9, 10, 11, 12] , may represent a feasible, safe, and effective way to help patients to manage the aftermath of BC. Indeed, evidence suggests that BCSs who meet the PA guidelines for cancer survivors [13, 14] show more benefits on the prevention of recurrences and mortality, as well as on certain side effects of the disease, compared to BCSs who do not [3] . It is concerning, therefore, that only 8.9% of BCSs [15] meet the current guidelines on aerobic and resistance exercise [15] . It is well known that the readiness and adherence of BCSs to exercise may be influenced by several factors, such as clinical complications (i.e., pain, fatigue, and cancer stage) [16] , psychological conditions [17] , social and environmental factors (including the availability or proximity of the training facilities) [16, 18] , and personal exercise preferences. In addition, knowledge of, engagement with, and motivation to exercise play an important role in promoting PA in BCSs [19, 20, 21] . However, unfortunately, only 40% of oncologists routinely recommend PA to patients [22] , and only 9% of BCSs are referred to exercise professionals [15] . This low-grade appointing to exercise professionals is particularly puzzling because he/she, in addition to act as trusted source of information and education, could manage and tailor the key components of exercise (i.e., frequency (F), intensity (I), time (T), type (T), volume (V), and progression (P) over time, namely the FITT-VP principle) [14, 23] to let BCSs safely obtain health benefits. This picture may be partially attributable to a poor understanding on how to promote, encourage and sustain people living with and beyond cancer to meet and adhere to the currently available PA recommendations [23, 24] . A recent meta-CART investigating which intervention strategy maximizes PA adherence showed that the major difference in effectiveness was attributable to supervised vs. unsupervised programs (dþ ¼ .49 vs. . 26) , and greater contact time was associated with larger effects in supervised programs [25] . However, in the last fifteen years, different approaches of supervision to PA and exercise have emerged in BCSs [24, 26] , and the term "supervision" has been used with different meanings and without proper specificity. In fact, it is sometimes intended as the clinical follow-up of self-managed or home-based exercise training programs and remote monitoring through wearable sensors or video recording [24, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40] , while sometimes it is used to also mean the direct on-site supervision of the training sessions [24, 41, 42, 43, 44, 45] . As a consequence, studies on PA and exercise training adherence used different assessment parameters (e.g., average, median, range, number or percentage of participants completing all or a certain percentage or number of sessions; number of participants meeting PA guidelines; minutes of PA achieved per week; etc.) [24, 37, 39, 40, 42] and reported mixed results with an adherence ranging, on average, from 50% to 80% [24, 36, 37, 39, 40, 42, 46, 47, 48, 49] . Moreover, the clinical team involved in supervised training is rarely described in BCSs studies, and, to our knowledge, only a few (e.g., see Rogers Laura et al. [49] ) described clearly that exercise training and supervision were provided by an exercise professional. Finally, about clinical outcomes (i.e., fitness measure, strength, and quality of life), small to moderate results in effect size with lack of precision were reported by different reviewers [24, 25] . Therefore, methods and efficacy of promoting a physically active lifestyle in BCSs have been poorly and confusedly studied. Particularly, the effectiveness of professionally guided exercise training and supervision on PA recommendations adherence has been poorly investigated in prior non-physically active BCSs. Thus, the present study aimed to compare the physical activity level, over 16 weeks, between a mixed on-site supervised exercise training group and a group receiving exercise education only. This pilot study was also designed to assess the feasibility, in the Italian clinical settings, of the MOTIVE program, which mixes exercise education and on-site supervised and tailored exercise training by an exercise professional to encourage BCSs to adapt an active lifestyle using an individually tailored exercise "dose". This pilot study was designed as a two-armed -Intervention and Control -controlled trial lasting 16 weeks (see Figure 1 for details). Intervention arm BCSs received the MOTIVE program, which consisted in a single exercise education session followed by a 8 weeks, 3 time-a-week supervised training program (see below for details). From week 9-16 of the trial, intervention arm participants were free to continue being physically active. Control arm BCSs received the exercise education session only and were free to adopt or not an active lifestyle throughout the 16 weeks duration of the trial. Participants of both groups were not contacted from week 9-16. Throughout the whole trial, participants had to collect data on their weekly PA habits in a diary (Figure 2) , which was picked up and replaced by the research staff at each follow-up. Assessments of study outcomes were performed at baseline (t0) and at 4 (t1), 8 (t2), and 16 (t3) weeks from t0. The procedures for this study were conformed to the Helsinki protocol for clinical trials and the study was approved by the local regional Ethics Committee (ANBU 03/2018). Women diagnosed with BC Stage I, II, or IIIa, consecutively referred to the Breast Unit facilities for clinical follow-up were recruited and checked for eligibility by the clinicians (oncologist or physiatrists) . BCSs were enrolled if they met the following inclusion criteria: 5 years after surgery for BC (mastectomy and/or quadrantectomy with or without axillary surgery); age from 30 to 70 years; ! 6 months since completion chemotherapy; not physically active (i.e., not meeting the physical activity guidelines for cancer survivors in the previous 6 months: 150 min/ week of moderate intensity aerobic exercise and two days/week of muscle-strengthening exercise [14] ). Exclusion criteria were: presence of medical contraindication to participation in a regular PA program (i.e., unstable angina, debilitating arthritis pain); disabling neurological or psychiatric disorders; BC recurrence; metastatic disease; moderate to severe walking disability. Enrolled BCSs were scheduled for a dedicated meeting with an exercise professional (the exercise education session), during which the supervised exercise training protocol was discussed in detail in order to assess participants' exercise preferences and rule out possible barriers (i.e., socio-economic, distance and time constraints). According to Wasmann et al. [50] , if the patient self-reported the preference to exercise under on-site supervision for 8 weeks (MOTIVE program), she was assigned to the Intervention arm, while patients who did not were assigned to the Control arm. The reason for acceptance or denial of the on-site supervision were collected. The exercise education session of the MOTIVE program consisted in a 30 min individual session in which an exercise professional encouraged the participants to be physically active (i.e., regularly engaged in PA), and explained the currently available exercise guidelines for cancer survivors [14] . PA goals, which were personalized, attainable, and timed, were set and discussed in detail. Participants were instructed on how to use the Talk Test [51] and Borg's rating of perceived exertion (RPE) scale [52] to self-monitor their compliance with the prescription of exercise intensity made by the exercise professional. Participants were provided with a PA diary ( Figure 2 ) as a tool to increase and maintain an active lifestyle [36] . The diary contains specific information on PA (i.e., explanations of the FITT principle and exercise recommendations) [14] and its benefits. BCSs were asked to record within the diary the "Start time", "Type" and "Duration" of each exercise session performed, and any relevant "Comments or notes". The PA diary was discussed with the patients at each follow-up to convey information on the benefits of the exercise performed, on any problem encountered during the training and, on the basis of this, to provide them with practical suggestions to start or continue to exercise regularly and autonomously. The training intervention of the MOTIVE program lasted 8 weeks. BCSs exercised 2 times each week (on non-consecutive days) under the supervision of an exercise professional (i.e., on-site supervision of the training sessions performed at the gym located inside the hospital) and 1 time each week autonomously, following the directions received by the exercise professional during the last on-site supervised training session. On-site supervised training sessions consisted in group-exercise designed according to the exercise guidelines for cancer survivors [14] . The exercise sessions started with 5 min of dynamic exercises (warmup), followed by 45-50 min of training (core part) and 5 min of light exercises (cool-down). The core part of each session was structured as a circuit with eight stations: seven resistance exercises and one aerobic exercise performed on a treadmill (model EE-0720, MTR, Italy). The circuit was repeated 2 times and each round always started with the aerobic exercise. Details of exercises part of the circuit training are reported in Table 1 along with exercise intensity and progression. During the not directly supervised sessions participants performed their own favorite aerobic exercise for at least 30 min. They were instructed to maintain the same level of intensity of their last on-site supervised training session by using the RPE scale and/or the talk test, and to log the main parameters of each session (type, duration, intensity, etc.) on the sheets of the PA diary. Adherence to the prescribed exercise intensity was recorded by the exercise professional in the training logs of the patients during the on-site supervised sessions, while adherence to the directions of the exercise professional was monitored and retrieved by using the self-report sheets of a PA diary than BCSs had to fill-in. The following parameters were assessed at each time point. Anthropometry: body mass; height; waist circumference. Cardiovascular parameters: resting blood pressure; resting heart rate. PA level [primary outcome]: assessed using the International Physical Activity Questionnaire -Short Form (IPAQ-SF) [53, 54] . Health-related fitness parameters [secondary outcomes]: assessed using the 6-min walk distance (6MWD) [55] , the isometric hand grip strength (HGS) [56] , and the distance of the sit-&reach test (SRT) [14] . Health-related quality of life questionnaire [secondary outcomes]: 36-Item Short Form Health Survey (SF-36) questionnaire [57] . The body mass index (BMI) was calculated using body mass and height (kg/m 2 ). PA level assessed at t0 was deemed representative of participants' actual status of non-physically active subjects when they stated that their answers would have been the same if the questionnaire was administered in the previous 6 months. Diary completion rate was also reported to describe the process and was calculated as the percentage of given answers (about weekly physical activities) with respect to requested answers per follow-up period. The sample size was calculated using the Wilson's confidence interval method [58] with 95% confidence level, which resulted in 10 subjects per group who were needed to evaluate an adherence of 90% (i.e., 9 over 10 subjects who maintain, at t3, the PA level recommended by the exercise professional and based on current exercise guidelines for secondary prevention [13, 14] with an interval width of 0.9 (95% CI: 0.59-0.98). This number allows to obtain results characterized by an error compatible with the exploratory nature of the study. Data were described using mean, standard deviation (SD), range, median and interquartile range (IQR) for continuous variables, and numbers and percentage rates for categorical parameters. Within-group changes were checked using the Wilcoxon rank test between each time point. To highlight differences in measurement trends across groups, a change index (Δtn) was also computed for each outcome, at t1, t2 and t3: Δtn ¼ ([tn score-t0 score]/t0 score)x100 for each outcome. Intergroup differences were assessed using the Mann-Whitney U test to compare data between the two groups at each time point. α was set at .05. Twenty women were enrolled (baseline demographic and clinical data are shown in Table 2 ). Ten participants who reported to have not enough time to move from their own home (n ¼ 2) at the scheduled times or to have distance-related problems (n ¼ 8) were assigned to the Control arm. At baseline no differences were found in demographic and basal clinical data between the groups. All participants did not meet the exercise guidelines for cancer survivors [14] and, on average, were overweight. Control arm women were slightly (but not significantly) more active than Intervention arm women. No adverse events were recorded during the study for any of the participant. Intervention arm BCSs attendance rate for the supervised exercise sessions was 94% (one absence per participant on average) and their PA diary completion rate was 100% at t1 follow-up, 98% at t2, and 94% at t3. In the Control arm, subjects' PA diary completion rate was 99% at t1 follow-up, 93% at t2 and 89% at t3. Intervention arm participants, at t1, increased their PA level more than two-fold compared to t0 (MET•min/week t1 ¼ 1111. 8 Figure 3 ). At each of follow-up, the Intervention arm change index was significantly higher than Control arm. Table 3 shows details of descriptive and comparative statistical results. At t2, the effect size of training supervision, with respect to selfadministering the training program, on PA levels was 1.9 [1.0-3.1] (Hedges' g [95% CI]), while at t3 follow-up was 1.12 [0.21-2.12] (Hedges' g [95% CI]). At t3 the number of Intervention arm participants who continued to yield autonomously an average energy expenditure attributable to PA higher than 700 MET-min/week was 9 out of 10 (90%), while in the Control arm they were 1 out of 10 (with other 2 participants who yielded an energy expenditure higher than 600 MET-min/week) ( Compared to t0, HGS improved significantly in Intervention arm participants at the t2 follow-up (Z ¼ -2.66; p ¼ .008). This score was higher than the HGS score in the Control arm at the same time point (Z ¼ -1.9; p ¼ .049). No other statistically significant differences were found in the intra-group and inter-groups analyses (Table 3) . Results of the SRT test showed no significant changes in either of the groups at the t1, t2 and t3 follow-ups. No inter-group differences were found either (Table 3) . At the baseline women enrolled in the study walked 476 m on average (standard deviation ¼ 72), without differences between Intervention and Control arm. At the follow-up assessments, subjects in the Intervention arm performed significantly better than Control arm subjects in the 6MWD (Table 3) . Moreover, nine out of ten of the Intervention arm participants improved their performance in the 6MWD at t1, and all ten Core part (from 45 to 50 min) n.a. n.a. The core part consisted in circuit training exercises structured into 8 stations: 1 aerobic exercise and 7 resistance exercises. Participants always started the circuit with aerobic exercise, which was followed by the resistance training exercises (one for each station); the whole circuit was then repeated. Walking Ranges of the average speed of the 6MWD: L1) 80-89% L2) 90-99% L3) 100-110% Treadmill One familiarization session. The walking intensity was tailored on the basis of each participant's average speed of the 6MWD. During the first week of training speed was set at 80% of the average speed of the 6MWD and progressed to 90%, 100%, and 110% in the next three weeks. Then, a second 6MWD was performed and the walking speed of the following four weeks of training was set at 80%, 90%, 100%, and 110% of the new average speed, respectively. Aerobic exercise duration progressed from a minimum of 15 min to a maximum of 20 min throughout the training intervention. Since the circuit was always repeated, each session consisted in a minimum of 30 to a maximum of 40 min of aerobic exercise, interspersed by approximately 5 min of resistance exercises. The 15-point Borg's RPE scale, which ranges from 6 ("no exertion at all") to 20 ("maximal exertion"), was periodically assessed. Push-up Starting position: L1) Wall push-ups (while standing) L2) Push-ups on knees L3) Push-ups (regular) Resistance exercise was performed for 30s each station, followed by 20s of rest that progressively reduced to 10s throughout the training intervention. Hence, each 40-50 s, the participant moved to another station and completed the resistance exercise part of the circuit in about 5-6 min. During the 30s of exercise, the participant was asked to perform 8 to 10 repetitions of the specific resistance exercise of that station at a comfortable cadence (which resulted in an average of about 3s each repetition, i.e., %1s for the concentric part and %2s for the eccentric part). All participants began the intervention program exercising at the lowest among three levels of intensity. When the participant was able to perform more than 10 repetitions for the given time was instructed to adopt the next intensity level in the following supervised exercise session. Note: Each participant began the intervention program exercising at the lowest level of intensity (L1) and any time she was able to perform more than 10 repetitions in 30s she progressed to a higher level of intensity (L2 or L3) starting from the next supervised exercise session. Exercise progression occurred with the passage from level 1, to level 2 up to level 3. Abbreviations: 6MWD, 6-min walk distance; RPE, Borg's rating of perceived exertion scale; n.a., not applicable. showed improvements at t2; five of them showed improvements in their performance that were greater than the minimal clinically important difference (MCID ¼ 30 m according to Bohannon The Intervention arm reported better Quality of Life (QoL) in several areas at the t1 follow-up assessment. Intervention arm participants had significantly higher scores (indicating better QoL) on scales measuring 'physical functioning' (Z ¼ -2.8; p ¼ .005), 'role limitation due to physical health' (Z ¼ -2.0; p ¼ .04), 'social functioning' (Z ¼ -2.3; p ¼ .02), 'bodily pain' (Z ¼ -2.5; p ¼ .01) and 'general health perceptions' (Z ¼ -2.8; p ¼ .005) ( Table 4 ). The main finding of the present study is that the MOTIVE program, which comprises an exercise education session and a mixed on-site supervised and tailored exercise training protocol of 8 weeks, produced a significantly greater increase and maintenance of BCSs PA level compared to autonomous and self-administered exercise session based on an exercise education session and clinical follow-up only. Our results are partially consistent with previous studies on BCSs [41, 42, 43, 44, 45, 60] . In the Intervention arm, that received 8 weeks of supervised exercise, the PA levels improved compared to Control arm. Although the PA levels of the Control arm were also increased at t1, our results show that only the PA levels of the Intervention arm were maintained at t2. Over time, when Intervention arm did not receive exercise supervision, PA levels of this participants also decrease. In this context, it is interesting to note that after the MOTIVE program women reached a high level of PA differently from many previous studies which showed statistically significant effects with smaller effect size tested on a shorter follow-up [24, 25] . Our results report than 90% of subjects maintain recommended PA levels even at the end of the MOTIVE program and, in particular in the following 8 weeks unsupervised on-site by an exercise professional. Previous trials have shown that patients' adherence to international guidelines on PA ranges from 5.4% [14] to 44% [15] after an active lifestyle counselling program. Approaches based on supervised exercise training improved adherence to PA guidelines with an effect size that ranged from 0.6 [44] to 1.02 [45] . In the present investigation, the effect size in the Intervention arm reached 1.9 after 8 weeks and 1.12 after 16 weeks of follow-up. Both effect sizes were greater than the effect size found by Rogers et al. [45] at a three-month follow-up following individual training. Indeed, we selected group training because [44] it has been shown to have a long-lasting motivational effect on BCSs, which was associated with a higher volume of PA even five years after the supervised PA intervention, with an effect size on adherence of approximately 0.6 [44] . Most of the literature reviewed to increase PA levels in BCSs women did not consider a mixed approach (i.e., MOTIVE program) or was out of the context of the Breast Unit's multidisciplinary team [24, 25] . The main differences of the MOTIVE program with respect to models described in the literature are: the presence of an exercise professional, the integration of this specialized figure in a Breast Unit and the assessment of barriers or preferences. This organization allows a personalization of the proposed exercise and the PA based on the knowledge of clinical information given by clinicians, women preferences and on the basis of FITT principle [14] . Despite this, a reduction in PA levels was observed in both groups of the present study during the second part of the trial, when women exercised autonomously according to the directions received by the exercise professional during the last supervised training session. Furthermore, at the end of the study, the PA did not reach the internationally recommended levels [13, 14] . Counselling is known to guarantee less than 50% adherence to international recommended PA levels [13, 14] and supervision is a powerful way to improve the amount of PA [25] . However, ongoing supervision is costly and difficult for the health system to sustain. In this study, specialized supervision performed for 8 weeks was helpful in achieving a high level of physical activity in BCSs, which may remain adequate for secondary and tertiary prevention even after two months of discontinuing supervised exercise. A large body of evidence shows that low cardiorespiratory fitness in BC patients is a strong, independent, and modifiable risk factor for premature mortality and increases the risk of cardiovascular disease [61] . Therefore, physical activity becomes increasingly important for BC patients during treatment and rehabilitation. When prescribing physical activity for BCSs, all precautions should be taken into account, including the patients' current fitness level and general health. The 6MWD is a relevant parameter for the assessment and monitoring of cardiorespiratory fitness in medical and exercise interventions also for BCSs [62] . The women enrolled in the study are representative of the general BCS population, in fact they covered 476 m in 6 min, showing performance at the lower limits of the norm for age as reported in But-Hadzic et al. [62] . The Intervention arm showed improved performance in cardiorespiratory fitness after the supervised training. Indeed, nine out of ten of the Intervention arm participants showed significant improvements in their 6MWD performance at t1, and all the Intervention arm participants showed significant improvements at t2. Notably, five out of ten of the Intervention arm participants showed improvements in their 6MWD performance that were greater than the minimal clinically important difference (MCID, i.e. 30 meters) [59] at t1 and six out of ten at t2; nine of the Intervention arm subjects maintained their fitness level at t3. On the contrary, Control arm participants showed a decline in their 6MWD performance over time. The fitness level is known to be related with BCSs psychological state, quality of life, and body composition [62] ; indeed, we found associations between PA levels and QoL. Closer examination of the SF-36 domains revealed that the improvement in the Intervention arm was greater than that which was found the Control arm; hence, this may be a clinically important improvement, which is in line with previous findings obtained with different protocols and under different conditions [63, 64, 65] . Recommendations suggest that BCS should engage in resistance exercise [14] . Anyway, according to Lahart et al. [24] , less than the 40% of trials published online proposed a training protocol that combines cardio and resistance training. In this study, HGS, a measure of muscular fitness, increased at the 8-week follow-up in Intervention arm participants, who performed 75% better than Control arm participants. However, HGS gains were not maintained in the long-term, possibly indicating that more attention and insistence must be placed during the exercise education session in explaining the usefulness of muscle strengthening. The measure of flexibility (SRT) has not changed significantly in both groups and the low "dose" of flexibility exercises prescribed may explain this result. Furthermore, the proposed training program based on the FITT principle [14] proved to be safe, considering that no side effects or complications were reported in either group. To our knowledge, these results has never been investigated in parallel studies as well as in the Italian clinical settings. Finally, between factors influencing PA behavior, barriers and accessibility to services [66, 67] are important issues that can affect adherence to exercise, together with the age, education and social status of the subjects [19] . The present investigation showed that only half of the enrolled subjects were able to reach the hospital to undergo the supervised exercise training sessions, highlighting the problem of the accessibility of the healthcare services. This problem is particularly serious in the Italian clinical setting and in the management of BCSs, not only under normal conditions but also during major emergency (e.g., COVID-19 pandemic) that could limit access to many health services, including rehabilitation [65, 68] . For people living with and beyond cancer, is important maintaining an exercise regimen for improvement of important clinical outcomes and, to date, the challenge for clinicians caring for these patients is to provide safe and effective exercise protocols which patients may adhere to in the longer term. Considering the impact on PA level, the MOTIVE program represents a promising tool for secondary/tertiary prevention and to help women stay active. Therefore, this approach should be scalable over a large sample size in order to prove that a spread of services dedicated to physical activity and the inclusion of the exercise professional in the multidisciplinary team for the management of the BCSs would be clinically important. There are a few experiences in Italy of effective and Note: values are expressed in % and were calculated using the following formula: Δtn ¼ ([tn score-t0 score]/t0 score)x100. Abbreviation: SD ¼ standard deviation. V. Natalucci et al. Heliyon 7 (2021) e08252 widespread integration between exercise professional and breast units [60, 69] . Its dissemination requires an appropriate health policy, that recognizes the key elements that have proved to influence the cancer patient's experience, including the commitment of a multidisciplinary team in care and treatment [70, 71] . Our study re-enforces the importance of mixed approaches in future studies looking at care integration and its impact on BCSs. This study has two main limitations that need to be acknowledged: a small sample size and a not-randomized controlled design. Statistical analysis was adapted in order to reduce selection biases using analysis tests for non-parametric data. However, a larger sample size is hopeful in a scaled-up study. As regards the non-randomized controlled design, we chose to ask the patients about barriers to exercise according to the "partially randomized patient preference trials" design proposed by Wasmann et al. [50] , which seems to be a reliable alternative for RCTs in trials comparing treatments of vastly different nature or using patient-centred outcomes in order to enroll a wide range of participants and optimize outcomes reporting. According to Wasmann et al. [50] , "in case patients" preference can be assumed, a "partially randomized patient preference trial" enables "faster inclusion of a more representative population improving external validity without compromising internal validity". Furthermore, through it, the study can provide information on facilitators or barriers in the processes of implementing health protocols. A wider population will allow to improve heterogeneity of the sample. Population heterogeneity will be addressed both in the sample and in the exercise program: individualized programs based on disease stage, treatment, comorbidities should be considered in future research questions. In addition, demographics and composite factors that would have an effect on exercise and its outcomes, such as patients' previous exercise habits, socioeconomic status, or other potential barriers to physical access to exercise, will need to be carefully considered. In our study, we did not evaluate hydration data. However, in a scaled-up study it would be interesting to include further outcome measures among those directly related to health and prevention, such as body composition. Indeed, since obesity is related to prognosis in breast cancer [72, 73, 74] , an objective measure of fat mass, fat-free mass and hydration (e.g., by using the bioelectrical impedance analysis) may improve the understanding of the health-related effects of training in BCS. Finally, assessing the MOTIVE program on a longer follow-up will give insights on structured and unstructured PA in secondary and tertiary prevention in BCSs. In fact, at this time, literature cannot provide any conclusions regarding the relation between PA and breast cancer-related and all-cause mortality or breast cancer recurrence [24] . Promoting awareness and improving information for both patients and clinicians could be the winning key: our proposal underlines the importance of an expert multidisciplinary approach that will be improved overcoming barriers, human, social and environmental, in order to promote an effective approach on secondary and tertiary cancer prevention. The MOTIVE program, as a pilot study, is a useful and sustainable methodology applicable in routine clinical setting based on the involvement of an exercise professional in the multidisciplinary team of the Breast Unit. It showed more efficacious than counselling or clinical follow-up alone in order to reach and maintain, over 16 weeks, an optimal adherence to the recommended PA level according to both exercise guidelines for cancer survivors and FITT principles [13, 14] . These results can confirm the efficacy of multidisciplinary clinical practices that focus on improving BCSs lifestyle behaviors as secondary and tertiary cancer care. Anyway, an adequate health policy, that brings the program closer to the subject, could optimize its results, recruiting as many subjects as possible. Valentina Natalucci and Marianna Capecci: Conceived and designed the experiments; Performed the experiments; Analyzed and interpreted the data; Wrote the paper. Manuela Marchegiani: Performed the experiments; Wrote the paper. Francesco Lucertini: Analyzed and interpreted the data; Wrote the paper. Maria Gabriella Ceravolo, Mirco Pistelli, Rossana Berardi, Luciana Vallorani, Giorgio Brandi and Elena Barbieri: Contributed reagents, materials, analysis tools or data; Wrote the paper. This work was supported by the University of Urbino Carlo Bo, Department of Biomolecular Sciences (under the grant "Progetti di Valorizzazione 2018" n. 28/2018). Data included in article/supplementary material/referenced in article. The authors declare no conflict of interest. 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