key: cord-1027382-ls6tc2vr authors: Ahmad, Shoaib; Lucero-Prisno, Don Eliseo; Essar, Mohammad Yasir; Khan, Hiba; Ahmadi, Attaullah title: Pakistan and COVID-19: The mystery of the flattened curve date: 2021-01-11 journal: Journal of global health DOI: 10.7189/jogh.11.03013 sha: bc73f9c4f6246c7252883be3572f62a918906e4a doc_id: 1027382 cord_uid: ls6tc2vr nan T he novel coronavirus (COVID-19) is a public health emergency of international concern that has triggered a huge burden on the world, specifically developing countries [1] . As of 24 September in Pakistan, a total of 308 208 positive cases have been confirmed with a total of 6437 people having succumbed to the virus. Very surprisingly, Pakistan is at 128 th on the list of positive COVID-19 cases per a population of one million and 113 th in the list of COVID-19 related deaths per a population of one million [2] . This was a completely unforeseen set of results as Pakistan, a developing country, was deemed to be one of the least prepared countries to face a pandemic of this nature owing to its fragile health care system, lack of resources, and low literacy rate across the country [3] . Lockdown, contact tracing, and case isolation are measures that have been proven to be effective in controlling an outbreak [4] . Consequently, the Pakistani government took rigorous measures to control COVID-19 spread initially by imposing a comprehensive lockdown [5] . However, the country soon gave up this pursuit and the lockdown was lifted in the first week of May, 2020, as the public was urged to live with the virus despite the rising cases. The World Health Organization (WHO) suggested on 10 June 2020 to re-impose a partial lockdown but the prime minister refused [6] . He insisted that the economy could not survive a further lockdown with more job losses and increasing numbers of hungry people. Pakistan and COVID-19: The mystery of the flattened curve Pakistan, a developing country, managed to flatten the curve against all odds despite less stringent policies by the government and less compliance to preventive measures by the public. The factors involved, sequence of events and the measures taken by Pakistan need detailed surveillance as it can help us flatten the curve in other countries by replicating similar measures. Overall, lack of lockdown-regulations, negligible implementation of preventive measures, lack of preventive resources, lack of knowledge in the public, mass gatherings in worship places, and an already fragile health care system, had put Pakistan on a road destined to make it one of the worst hit countries by this pandemic [7] . A study by Imperial College London had predicted by various algorithms that Pakistan would report the highest number of deaths on the 10th of August 2020 with the total reaching 78 515 after which Pakistan would witness a decline [8] . Views on the mystery of flattened curve in Pakistan: • The very possible confounding factor of decreased number of cases is the disparity in reporting the data and the government trying to delude the public to prove its policies to be stronger than in reality. On the other hand, this can be contradicted by the evidence of no spike in graveyard data and the continuous fall in demand for pressurized oxygen and ventilators. The claims by very credible health care professionals of decreased hospital workload also support this theory of low intensive healthcare demand. Moreover, Pakistan managed to pay heed to other epidemics like polio and was able to carry out 4 immunization drives unlike other endemic countries like Afghanistan [9] . • Pakistan's government has had a lesser stringency index than their neighboring countries like India for example, as Pakistan preferred to impose a "smart" lockdown instead [10] . This stringency index is calculated by several policies imposed by the government including school and work-place closure, restrictions on gatherings, transport restrictions, and stay at home requirements. Since climate conditions of both countries are alike and the immunization status of both Pakistan and India are not so different, the stringency index can be the one major difference that might have turned the tide in Pakistan's favor but there is still no evidence in corroboration of this theory. • Another theory to the flattened curve is the decreased number of tests conducted. However, this factor also cannot be attributed to a seemingly controlled outbreak as the positivity rates are very low, i.e. no. of confirmed cases/total no. of tests conducted [10] . The average positivity rate for Pakistan is less than 5% in August 2020 and declines further below 2% by September 2020 as shown in Figure 1 . This figure is well below the WHO recommended figure of 5% which when achieved means the outbreak is well under control. Nonetheless, the controlled outbreak can be due to a number of factors with the most proposed ones being: • A non-specific immunity due to immunization by various vaccines like BCG but there are still detailed clinical trials required to develop a causal relationship [11] . • The humidity in the current monsoon season and a comparatively higher temperature which is thought to attribute to the decreased spread of virus [12] . Funding: No funding from any institution or department. Authorship contributions: AS and DEL-P conceived the idea. AS, AA, EMY and KH contributed in writing the draft, collecting, and interpreting data. DEL-P and AS edited the final draft. All authors revised and approved the final manuscript. The authors have completed the ICMJE Unified Competing Interest form (available upon request from the corresponding author) and declare no conflicts of interest. To conclude, it is a fact that Pakistan has gotten an optimal hold of the coronavirus outbreak considering their lack of preventative measures. However, declaring victory can be a major blunder as daily cases are still being reported in hundreds. Pakistan should be well prepared for a second wave as the government has already opened schools and universities starting from September 15, 2020. The factors adding up to this recovery are still ambiguous as neighboring countries with similar factors and behaviors are still struggling. The sequence of events and measures taken by Pakistan need detailed surveillance as it can help us flatten the curve in other countries by replicating similar measures. WHO Coronavirus Disease (COVID-19) Dashboard. Available Is Pakistan prepared to tackle the coronavirus epidemic? Feasibility of controlling COVID-19 outbreaks by isolation of cases and contacts COVID-19 outbreak: current scenario of Pakistan How did Pakistan avert disaster Coronavirus command center reports people not following SOPs -Pakistani planning minister. Arabnews. 2020 New algorithm shows alarming number of COVID-19 deaths in Pakistan by August 10. Geo News Polio Amidst COVID-19 in Pakistan: What are the Efforts Being Made and Challenges at Hand? Coronavirus Pandemic (COVID-19). Our World in Data Correlation between COVID-19 case fatality rate and percentage of BCG vaccination: is it true the vaccine is protective? Effects of temperature variation and humidity on the death of COVID-19 in Wuhan