key: cord-1027101-fztnc2pa authors: Pillay, Yogan; Johnson, Leigh title: World AIDS Day 2020: Reflections on global and South African progress and continuing challenges date: 2021-03-10 journal: South Afr J HIV Med DOI: 10.4102/sajhivmed.v22i1.1205 sha: 4219016ffd2cfe8087ab3f6c8293934e8879db34 doc_id: 1027101 cord_uid: fztnc2pa BACKGROUND: Reflecting on progress and challenges in meeting global human immunodeficiency virus (HIV) targets is often done ahead of World AIDS Day. This article reflects on progress and the continuing challenges in meeting targets in South Africa (SA). OBJECTIVE: To review policy and implementation related progress and continuing challenges towards eliminating HIV as a public health threat by 2030. METHOD: Policy analysis and review of modeling data from Thembisa 4.3. RESULTS: South Africa has made significant progress in the adoption of policies with two exceptions. While there are gaps in reaching the 90-90-90 implementation targets, progress has been made in the past decade. CONCLUSION: While progress has been made in the past decade towards the global targets, much work remains to ensure that HIV transmission is curtailed and those that require treatment are initiated on treatment and are virally suppressed. such as multi-month dispensing in Burundi, the Dominican Republic, Ethiopia, Mozambique, Papua New Guinea and SA. This reduced the need for clinic visits to collect ARV treatment. In Botswana, Kenya, Rwanda and SA, voluntary medical male circumcision (VMMC) has restarted since the imposition of strict lockdowns. Despite these initiatives, there is widespread concern about the disruption of essential services by COVID-19. Implementation of interventions to prevent HIV and get people onto treatment as soon as they are diagnosed starts with good policies. South Africa has long been feted as having exemplary policies. The 2020 Global HIV Policy Report 2 shows that amongst countries in eastern and southern Africa -countries with the largest burden of HIV -SA has the highest overall policy-adoption score. The report suggests that SA has yet to make progress in the following three areas. The use of national laws to take advantage of the flexibilities in the Agreement on Trade-Related Aspects of Intellectual Property Rights (TRIPS) to procure medicines at more affordable prices, the decriminalisation of sex work and the personal possession and/or use of drugs. South Africa has used its large volumes and tender-pricing system to drive down national and global prices but has not utilised provisions of TRIPs such as compulsory licensing and parallel importation. Although the former Deputy President Mr. C. Ramaphosa publicly launched an HIV programme for sex workers and declared that 'sex work is work', this has not stopped police harassing sex workers. 6 With respect to the legalisation of drug-use, to date only the private use of marijuana is legal but not its sale. However, drug use by the more than 75 000 injecting-drug users continues to be criminalised in SA, a situation that fuels both HIV and hepatitis transmission. 7 South Africa must move more rapidly to a clearer policy on the decriminalisation of sex work and of injecting-drug use. In addition, the SA government must give greater consideration to the flexibilities of TRIPS where medicine prices are not being reduced to affordable levels. In this report, we have used estimates from the Thembisa 4.3 model, an integrated HIV/demographic mathematical model developed for SA. This assesses the impact of different HIV programmes at a national and provincial level. Estimates from the Thembisa 4.3 model were released in November 2020 ahead of World AIDS Day 2020. With respect to new HIV infections, there were 201 000 new HIV infections in 2018-2019: 121 000 in women, 67 000 in men and 11 600 infections from mother-to-child-transmission (MTCT). The majority of the latter (69%) occurred during the breastfeeding period. The total number of new infections in 2009-2010 was 412 000 -which implies a 51% decline in new infections over the 2010-2019 period. However, it is more meaningful to assess changes in HIV incidence rates in 15-49-year-olds. Changes in population growth and the population age distribution affect the absolute numbers of new infections. Using this metric, HIV incidence rates in SA declined by 55% over the 2010-2019 period, with the decline being greatest in KwaZulu-Natal (KZN) (61%) and least in the province of the Western Cape (34%). This decline in HIV incidence in KZN was confirmed in population-based surveillance studies. 8 In terms of the drivers of these declines in KZN, high coverage of VMMC and greater access to ARVs have been suggested as contributory and recommended to be scaled up in other provinces. 9 The highest Thembisa-model HIV incidence-rates are in MSM (2.60%) and female sex workers (FSWs) (5.50%). However, there have been significant declines in these cohorts. The incidence in MSM has declined from 5.69% and in FSWs from 10.96% in 2010. Although these are encouraging estimates, they largely reflect the impact of general HIV prevention and treatment programmes. 10 Interventions such as pre-exposure prophylaxis (PrEP), which has been provided to FSWs and MSM, still have low uptake and retention rates. The model estimates a 2019 PrEP coverage rate of 3% and 1% in FSWs and MSM, respectively. These groups require special attention with respect to prevention and significantly increased access to treatment. Over the past decade, there has been concern about HIVinfection in adolescent girls and young women (AGYW) aged 15-24 years. The Thembisa model estimates that the incidence rate in this cohort has declined from 2.98% in 2008 to 1.30% in 2018. These reductions are largely because of increased HIV testing, ARV coverage and high levels of condom use. Whilst still unacceptably high, this decline is important. Human immunodeficiency virus-incidence rates in adolescent boys and young men (ABYM) are lower in both 2008 and 2018 periods: 1.03% and 0.33%, respectively. 10 Gender inequalities and transmission of HIV from older men to AGYW are posited as the main drivers of the incidence-differences between AGYW and ABYM. 11, 12 New infections at birth have declined from 18 300 in 2010 to 3600 in 2019: a decline of 80%. This is a consequence of the greater proportion of infected mothers on ART during pregnancy and at delivery, 32% in 2010 and 97% in 2019. However, the decline in new infections related to breastfeeding has been less dramatic: 22 000 (2010) to 8000 (2019) -a 63% decline. Breastfeeding mothers need greater support from healthcare professionals and their families/ communities. Pre-exposure prophylaxis in pregnant and breastfeeding mothers can reduce vertical transmission by 40%. 13 Preexposure prophylaxis is safe in breastfeeding -with minimal infant-drug exposure. 14 The use of PrEP as part of a comprehensive package of interventions in countries with a high HIV prevalence is endorsed by the WHO in both antenatal and postnatal care. 15 Prevention starts with knowing one's status. A combination of interventions accounts for prevention successes of the past decade. But greater effort is needed. The Thembisa 'ever-tested-for-HIV' model estimates the percent of adults tested increased from 47.3% in 2010 to 76.3% in 2019. A total of 81% of SA women compared with 72% of men had ever-tested by 2019. Despite the provision of free male and female condoms by the SA government, their use at last sexual encounter increased marginally from 23% (2010) to 29% (2019) amongst women aged 25-49 years. Only 27% of 15-to 24-year-old females used a condom at their last sexual encounter. (Note that the Thembisa estimates are lower than self-reported rates as they are adjusted for social desirability-bias in self-reported data). As the most effective barrier method for the prevention of sexually transmitted infections (STIs) and unplanned pregnancies, more attention needs to be paid to convince South Africans of their value. The national SA-PrEP programme was introduced in 2016 and provided oral PrEP to sex workers. The programme was expanded in 2017 to include college and university students at onsite health clinics. Since 2018, PrEP has been provided in public health clinics. Increasing access and improving adherence to ARVs for growing numbers of South Africans means accessing the latest, safest and best-tolerated ARVs at lowest cost. The newest (November 2019) of fixed-dose combinations in the SA public health sector is TLD: tenofovir (TDF), lamivudine (3TC) and dolutegravir (DTG). Whilst there are concerns about the long-term consequences of weight gaingreater in women than men, the combination is well tolerated and presents the virus with a high-barrier to resistance. Paediatric-DTG in a dispersible tablet is an important advance for infants and children living with HIV who are ≥ 4 weeks of age and weigh at least 3 kilograms (kg). Despite being endorsed by the WHO, paediatric-DTG has not as yet been registered for use in SA. 17 How did SA do in the light of the UNAIDS' 90-90-90 targets? The Thembisa estimates for adult women, males and children are presented separately to illustrate the variation across these groups ( At the beginning of each December since 1988, the global AIDS community and partners reflect on progress made in turning the tide on the HIV epidemic and consider the challenges as well as the work that remains to eliminate HIV as a public health threat. The year 2020 was especially challenging given the impact of the COVID-19 pandemic on individuals, families, and the local and global community. Health and social services were disrupted in many parts of the world making it difficult for people to access services. There is now a need for recovery and a reset to ensure that the gains made in the HIV programme, in SA and globally, are not lost and that we can accelerate towards the new targets that UNAIDS 18 has proposed -of achieving the expanded 95-95-95 targets by 2025, as well as removing punitive laws, decreasing stigma and discrimination, and decreasing gender inequality and violence. This article followed all ethical standards for research without direct contact with human or animal subjects. This research received no specific grant from any funding agency in the public, commercial or not-for-profit sectors. All data are secondary data, which are publicly available and referenced. 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Preventing HIV during pregnancy and breastfeeding in the context of PrEP: Technical brief The prevalence of selected non-communicable disease risk factors among HIV patients on anti-retroviral therapy in Bushbuckridge sub-district, Mpumalanga province WHO welcomes FDA approval of new formulation of dolutegravir for young children living with HIV AIDS targets: Putting people living with HIV and communities at risk at the centre The authors declare that they have no financial or personal relationships that may have inappropriately influenced them in writing this article.The views and opinions expressed in this article are those of the authors and do not necessarily reflect the official policy or position of any affiliated agency of the authors. Authors' contributions Y.P. conceptualised and wrote the first draft; L.J. provided the South African estimates and revised the draft.