key: cord-1026460-8jhaxcn1
authors: Ressaire, Quentin; Dudoignon, Emmanuel; Moreno, Nabila; Coutrot, Maxime; Depret, François
title: Low total cholesterol blood level is correlated with pulmonary severity in COVID-19 critical ill patients
date: 2020-08-28
journal: Anaesth Crit Care Pain Med
DOI: 10.1016/j.accpm.2020.07.015
sha: 0aedb3f2053b27479ffb543f909053564953a621
doc_id: 1026460
cord_uid: 8jhaxcn1

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apolipoproteins is associated with poor prognosis in patients with COVID-19, and may be an important feature to consider in understanding the pathophysiology of COVID-19.

To explore this pathway, we conducted a retrospective single centre study on prospectively collected data. Every patient admitted in Saint-Louis Hospital's Surgical Intensive Care Unit (ICU) (Assistance Publique -Hôpitaux de Paris, Paris, France) for respiratory failure related to COVID-19 and who had an exploration of lipid abnormalities at ICU admission was included.

Exclusion criteria were age under 18, pregnancy or moribund patient at admission.

Methods to determine cholesterol blood levels (TC, LDL-c, HDL-c, triglycerides) were enzymatic colorimetry and immunoturbidimetry for apolipoproteins (A1 and B).

All patients or their surrogate had information about the data collection and gave their nonopposition to the study (Ethical committee of the French Society of Anaesthesia and Intensive Care [SFAR] IRB 00010254 -2019 -203). Continuous variables were described as median with their interquartile ratio (IQR) while categorical variables were expressed as frequencies (%). After a normality test, data were analysed with a Mann-Whitney or a student t-test according to their distribution with a 5% first species risk. Spearman correlation test was used.

Of 54 COVID-19 patients admitted in our ICU from March 20, 2020 to April 15, 2020, thirtyone had an exploration of lipid abnormalities at admission (LDL-c, HDL-c, TC, apolipoproteins A1 and B (ApoA1 and B)). Patients' characteristics are summarised in Table 1 , and biological results of lipid profile in Table 2 . Among the 31 patients included, dyslipidaemia was not associated with mortality (Table 1) is associated with severity of the disease (4) and is also believed to be a potential therapeutic target (5) . More explorations are required to better understand and explain the role of lipid pathways in COVID-19 pathophysiology.

J o u r n a l P r e -p r o o f 

Cholesterol: A new game player accelerating endothelial injuries caused by SARS-CoV-2?

The National Heart, Lung, and Blood Institute ARDS Clinical Trials Network. Rosuvastatin for Sepsis-Associated Acute Respiratory Distress Syndrome

Association of Elevated Plasma Interleukin-18 Level With Increased Mortality in a Clinical Trial of Statin Treatment for Acute Respiratory Distress Syndrome*: Critical Care Medicine

Serum Cytokine and Chemokine profile in Relation to the Severity of Coronavirus disease 2019 (COVID-19) in China. The Journal of Infectious Diseases

Harnessing innate immunity to eliminate SARS-CoV-2 and ameliorate COVID-19 disease

QR, ED and FD designed the study, collected the data and drafted the manuscript NM conducted the assays and drafted the manuscript