key: cord-1026191-satvwfxy
authors: Yirmiya, Karen; Yakirevich-Amir, Noa; Preis, Heidi; Lotan, Amit; Atzil, Shir; Reuveni, Inbal
title: Women’s Depressive Symptoms during the COVID-19 Pandemic: The Role of Pregnancy
date: 2021-04-18
journal: Int J Environ Res Public Health
DOI: 10.3390/ijerph18084298
sha: fc9a7a74e2e22fc6b5beb7135eda9b92547ec950
doc_id: 1026191
cord_uid: satvwfxy

The Coronavirus Disease 2019 (COVID-19) pandemic has multiple ramifications for pregnant women. Untreated depression during pregnancy may have long-term effects on the mother and offspring. Therefore, delineating the effects of pregnancy on the mental health of reproductive-age women is crucial. This study aims to determine the risk for depressive symptoms in pregnant and non-pregnant women during COVID-19, and to identify its bio-psycho-social contributors. A total of 1114 pregnant and 256 non-pregnant women were recruited via social media in May 2020 to complete an online survey that included depression and anxiety questionnaires, as well as demographic, obstetric and COVID-19-related questionnaires. Pregnant women also completed the Pandemic-Related Pregnancy Stress Scale (PREPS). Pregnant women reported fewer depressive symptoms and were less concerned that they had COVID-19 than non-pregnant women. Among pregnant women, risk factors for depression included lower income, fewer children, unemployment, thinking that one has COVID-19, high-risk pregnancy, earlier gestational age, and increased pregnancy-related stress. Protective factors included increased partner support, healthy behaviors, and positive appraisal of the pregnancy. Thus, being pregnant is associated with reduced risk for depressive symptoms during the pandemic. Increased social support, engaging in health behaviors and positive appraisal may enhance resilience. Future studies of pregnant versus non-pregnant women could clarify the role of pregnancy during stressful events, and clarify aspects of susceptibility and resilience during pregnancy.

The Coronavirus Disease 2019 (COVID-19) pandemic created a global health crisis, and its mental health implications are only now beginning to unravel. Studies have reported increased levels of psychological distress, anxiety, depression, and post-traumatic stress disorder (PTSD) in the general population, and specifically in reproductive aged women [1] [2] [3] . The COVID-19 pandemic has multiple ramifications for pregnant women, including stress surrounding the uncertainty related to prenatal care and the risk of prenatal exposure to the virus [4] .

The psychological impact of major stressful events on pregnant and postpartum women has been previously studied with conflicting results [5] . Some studies suggest that peripartum women are at high risk for developing mental health problems in the the COVID-19 pandemic, and to identify bio-psycho-social contributors that increase the risk of experiencing depressive symptoms. The results of this study could contribute to the understanding of the role of pregnancy on the vulnerability for depression during times of global crisis.

During the second week of May 2020, we recruited a sample of 1380 women through women-related and pregnancy-related social media groups and public pages on Facebook. The advertisements invited non-pregnant women to share their experiences during the COVID-19 pandemic and pregnant women to share their pregnancy experiences during the COVID-19 pandemic. Our inclusion criteria were age 18 years or older and being able to read and write in Hebrew. There were no other exclusion criteria. Women who wished to participate in the study signed an electronic informed consent, and completed the questionnaires online through Qualtrics, a secure online survey system. After identifying 13 duplicate responses, the final sample included 1114 pregnant women: 81 in the first trimester; 430 in the second trimester; 570 in the third trimester; and 33 women who did not report their gestational age but were identified as being pregnant, and 256 non-pregnant women. The majority of women were born in Israel (N = 1187, 86.6%). Participants who completed the questionnaire were enrolled in a raffle to win a ILS 600 gift card (equivalent to approximately USD 150). The study was approved by the Hebrew University of Jerusalem Institutional Review Board on 11 May 2020 (approval number 114120).

Sociodemographic variables included age, years of education, economic status (below average/average or above average), relationship status (married or cohabiting/some or no relationship), current employment status (working or studying/homemaker, unemployed or receiving disability benefits), and number of children under 18.

COVID-19-related variables included having direct contact with an individual medically diagnosed with COVID-19 (no/yes), thinking that one had COVID-19 even if one was not tested (no/unsure/yes), and having access to outdoor space (yes, whenever I want/sometimes/rarely).

Depressive symptoms were assessed using the Patient Health Questionnaire-2 (PHQ-2) [43] , which includes the first two items of the PHQ-9 [44] . The two questions inquire about the frequency of depressed mood and anhedonia over the past 2 weeks, on a scale of 0 (not at all) to 3 (nearly every day). The final scores range from 0 to 6 with a higher score indicating a greater risk for depressive disorder. In addition, a cut-off of ≥3 was used. The PHQ-2 has been shown to be efficient to rule out depression in 60-80% of pregnant women [45] . In pregnancy, the sensitivity of the PHQ-2 was 69-84% and the specificity was 79-84% [45] .

Stress related to pregnancy during the COVID-19 pandemic was assessed using the PREPS questionnaire, a novel instrument created by Preis, Brittain, and Lobel [42] , a multidisciplinary research and clinical team with expertise in developing validated instruments to assess prenatal maternal stress and coping. Item themes were based on news articles and media interviews regarding women's experiences during the COVID-19 pandemic, as there was limited research available at the time [42] . Item wording was tested for face validity by pregnant and non-pregnant women before the Stony Brook COVID-19 Pregnancy Experiences (SB-COPE) Study launch. The PREPS questionnaire was translated to several languages, and was found to have good psychometric properties in different populations [46, 47] . For the current study, the scale was translated to Hebrew using the forward-and-back translation technique by bilingual researchers (see Supplementary Materials Figure S1 ). The instrument includes 15 items describing thoughts and concerns that pregnant women might have owing to the COVID-19 pandemic, rated on a scale from 1 (very little) to 5 (very much). The PREPS includes three independent, internally consistent, factors: stress associated with preparations for birth and the postpartum period (7 items; PREPS-Preparedness), stress associated with worries about perinatal COVID-19 infection (5 items; PREPS-Infection), and positive aspects of the pandemic in the context of pregnancy (3 items; PREPS-Positive Appraisal) [42, 48] . Confirmatory factor analysis (CFA) was conducted on the Hebrew version to replicate the three-factor structure of the PREPS previously identified, which yielded a good model fit (CFI = 0.929, TLI = 0.910, RMSEA = 0.078). The internal consistency of the subscales PREPS-Infection and PREPS-Preparedness was relatively high (α > 0.8). Although the internal consistency of the PREPS-Positive Appraisal subscale was lower than the α = 0.70 criterion, inter-item correlation coefficients of all items were > 0.32. Scale scores were calculated as the mean response to items on the corresponding factor.

General stress was assessed using a single general question: "How much stress do you currently have in your life?". Participants were asked to score their answer on a 5-point scale ranging from 1 (very little) to 5 (very much).

Anxiety symptoms were assessed using the Generalized Anxiety Disorder-7 (GAD-7) scale [49], a 7-item self-report instrument to assess anxiety symptoms. Respondents report the frequency of symptoms over the last 2 weeks on a scale ranging from 0 (not at all) to 3 (nearly every day). Individual scores were calculated as a sum of item responses ranging from 0 to 21. The GAD-7 was found to have good reliability and validity for screening anxiety among pregnant women [50, 51] .

Social support included two single-item questions on perceived support from family or friends and perceived support from a partner (1 = very little to 5 = very much).

Health behaviors were assessed by a single-item question assessing the extent to which women were practicing health behaviors, such as taking vitamins, exercising, and sleeping enough (1 = very little to 5 = very much).

Obstetric factors included gestational age (in weeks), self-reported high-risk pregnancy status (no/yes/unsure), and whether participants had a prenatal care appointment canceled or rescheduled owing to the COVID-19 pandemic (no/yes).

Statistical analysis was conducted using SPSS for Windows, version 23 [52] and AMOS 21 [53] . We used χ 2 and t tests to examine differences between pregnant and non-pregnant women, with p < 0.05 considered statistically significant. Propensity-score matching was performed using Stata version 16.1 [54] , KMATCH module [55] with the default parameters, which matches treated and untreated observations with respect to covariates based on propensity-scores, including estimation of treatment effects based on the matched/balanced observations, while including post-matching regression adjustment. For post-estimation evaluation of data balancing, kernel density estimates before and after matching were generated using the "kmatch density" command. Pearson's correlation coefficients were used to assess associations among all study variables. A hierarchical linear regression analysis was conducted among the pregnant women's cohort to predict the risk for depressive symptoms from all the sociodemographic, psychological, and medical factors. A second hierarchical linear regression analysis was conducted among the pregnant and non-pregnant cohorts with the same predictors as the first regression, to examine the contribution of these variables above and beyond the factor of pregnancy in predicting depressive symptoms.

Pregnant women reported significantly fewer depressive symptoms than non-pregnant women (see Figure 1a , Table 1 ). The difference in the depressive symptoms score remained significant even after controlling for age, education, relationship status, income, number of children and employment status (F (1) = 8.48, p < 0.005). Our data demonstrate that 15.6% of pregnant women were depressed, as defined by a clinical cut-off of 3 or higher [56] , whereas 21.9% of non-pregnant women reached this criteria (X 2 (1) = 5.83, p = 0.02). No significant differences were observed between pregnant and non-pregnant women in levels of stress and anxiety (Table 1) . Pregnant women were less likely to think that they had COVID-19 than non-pregnant women ( Figure 1b , Table 1 ). Pregnant women also reported having more social support and engaging in more health behaviors than non-pregnant women ( Table 1 ). All differences remained significant following the Bonferroni correction for multiple comparisons, except for education level.

number of children and employment status (F(1) = 8.48, p < 0.005). Our data demonstrate that 15.6% of pregnant women were depressed, as defined by a clinical cut-off of 3 or higher [56] , whereas 21.9% of non-pregnant women reached this criteria (X 2 (1) = 5.83, p = 0.02). No significant differences were observed between pregnant and non-pregnant women in levels of stress and anxiety (Table 1) . Pregnant women were less likely to think that they had COVID-19 than non-pregnant women ( Figure 1b , Table 1 ). Pregnant women also reported having more social support and engaging in more health behaviors than non-pregnant women ( Table 1 ). All differences remained significant following the Bonferroni correction for multiple comparisons, except for education level.

To account for potential sample selection bias, we applied regression-adjusted propensity-score matching using a combination of age and education (Supplementary Figure  S2 and Supplementary Table S3) or age, education, income and employment status (Supplementary Figure S3 and Supplementary Table S4 ) as covariates. The models showed that while providing the expected superior propensity-score matching, significant effects of pregnancy on PHQ2 scores were consistent with the non-matched results. To account for potential sample selection bias, we applied regression-adjusted propensity-score matching using a combination of age and education (Supplementary Figure S2 and Supplementary Table S3) or age, education, income and employment status (Supplementary Figure S3 and Supplementary Table S4 ) as covariates. The models showed that while providing the expected superior propensity-score matching, significant effects of pregnancy on PHQ2 scores were consistent with the non-matched results.

Being pregnant significantly predicted lower levels of depressive symptoms. Furthermore, women who had lower income, fewer children, women who were unemployed, and those who thought that they had COVID-19 were found to be at higher risk for depressive symptoms. Women with higher perceived partner support and women engaged in more health behaviors had fewer depressive symptoms. The current model explained 9% of the variance in depressive symptoms. The results of the hierarchical linear regression among pregnant and non-pregnant women, with the depressive symptoms score as the dependent variable, are shown in Table 2 . The associations between all predicting variables are detailed in Supplementary Table S1. Table 2 . Multiple hierarchical linear regression analyses-prediction of depression (PHQ-2) score among non-pregnant and pregnant women.

Step 1 (β)

Step 2 (β)

Step 3 (β)

Step Step 3: Social support and health behaviors Family/friends support (1-5) −0.04 Partner support (1) (2) (3) (4) (5) −0.10 ** Health behaviors (1) (2) (3) (4) (5) −0.11 *** F 7.95 *** 7.16 *** 8.17 *** R 2 0.05 0.06 0.09 ∆R 2 0.05 *** 0.01 ** 0.03 *** * p < 0.05, ** p < 0.01, *** p < 0.001.

Among the sociodemographic variables tested, pregnant women who had lower income, fewer children, and women who were unemployed reported elevated depressive symptoms. Women who believed that they had COVID-19 (even if not tested) also reported higher depressive symptoms scores. Women with higher perceived partner support and women who engaged in more healthy behaviors reported fewer depressive symptoms. Among the obstetric variables, having a high-risk pregnancy and earlier gestational age significantly predicted higher depressive symptoms scores. The above-mentioned variables together explained 12.5% of the variance in depressive symptoms among pregnant women. Finally, the PREPS-Preparedness stress scale predicted higher depressive symptoms scores, the PREPS-Positive Appraisal scale predicted lower depressive symptoms scores, while the PREPS Infection stress scale did not predict depressive symptoms. The final model explained 18.5% of the variance in depressive symptoms. The results of the hierarchical linear regression among pregnant women, with the depressive symptoms score as the dependent variable, are shown in Table 3 . Pearson's correlation coefficients among all predictive variables are presented in Table S2 in the Supplementary Material. Table 3 . Multiple hierarchical linear regression analyses-prediction of depression (PHQ-2) score among pregnant women.

Step 1 (β)

Step 2 (β)

Step 3 (β)

Step 4 (β)

Step 5 (β)

Step Step 3: Social support and health behaviors Family/friends support (1-5) −0.07 −0.06 −0.05 Partner support (1) (2) (3) (4) (5) −0.09 * −0.07 * −0.08 * Health behaviors (1) (2) (3) (4) (5) −0.14 *** −0.13 *** −0.09 * 0.05 *** 0.01 ** 0.04 *** 0.03 *** 0.06 *** * p < 0.05, ** p < 0.01, *** p < 0.001.

The outbreak of COVID-19 in Israel began at the end of February 2020 and reached the first peak during March and April 2020. During this time, an almost complete lockdown took place for 8 weeks, with substantial social and economic restrictions continuing for months. Furthermore, information on the effects of the virus on pregnancy outcomes and fetal development was scarce. Fear from being infected with the virus, social isolation and the economic turmoil caused by the pandemic had a notable impact on the mental health and wellbeing of the general population, with increased risk for depression and anxiety among women [1, 57] . The results of the present study indicate that during the first wave of the COVID-19 pandemic, pregnant women had fewer depressive symptoms than non-pregnant women. Moreover, pregnant women were less likely to think that they have COVID-19 than non-pregnant women. Our results are in line with previous studies that compared pregnant to non-pregnant women's responses to the COVID-19 pandemic [17, 58] ; however, these studies were with relatively smaller samples. Our results may indicate that being pregnant contributes to enhanced resilience in times of crisis and severe stress, and warrant further research on the underlying mechanisms.

Psychosocial determinants are well-known factors that affect vulnerability to experience depression throughout life, and specifically in the perinatal period. In the present study, pregnant women reported experiencing more perceived partner support than nonpregnant women, and partner support significantly predicted lower levels of depressive symptoms among pregnant and non-pregnant women during the pandemic. Partner support is a well-known protective factor against depression during the perinatal period [59] [60] [61] [62] , especially in times of crisis and stress [63] . These results are consistent with reports of pregnant women during the COVID-19 pandemic that demonstrate higher perceived social support was associated with less depressive symptoms [21] , whereas a lack of social support was related to increased risk for perinatal depressive symptoms [64] . In a mixed-methods pilot study from the US, pregnant women who reported feelings of isolation and loneliness also reported that partner support was the most important protective factor which helped them to cope with the pandemic [33] . Moreover, we found that health-related behaviors were significantly more frequent among pregnant women than among non-pregnant women, and that these behaviors also significantly predicted fewer depressive symptoms. The relationship between health behaviors and depression is well-established in the literature [65] [66] [67] , and specifically during pregnancy [68] . This relationship has been reported both at non-challenging times and during the pandemic [21, 69] . In a parallel study in the US, pregnant women who were engaged in more positive health behaviors were also found to have less anxiety symptoms [34] . A Finnish study monitoring pregnant women's daily patterns of heart rate variability, physical activity and sleep data showed that these variables were associated with coping better with pandemic-related restrictions [70] . Therefore, improving women's social support networks and encouraging socially distant healthy activities, such as online fitness classes suitable for pregnant women, may be targets for enhancing resilience to depression among pregnant women during the pandemic.

We found that vulnerability for depression is also associated with financial and employment problems. In Israel, pregnant women are protected by law from layoffs during pregnancy and the postpartum period [71] , and women receive paid maternal leave for the first fourteen weeks after birth [72] . These factors may protect against experiencing depressive symptoms and enhance resilience among pregnant women, especially in light of the detrimental economic and psychosocial effects of the COVID-19 pandemic. This is supported by recent findings from Canada, which showed that pregnant women with high income compared to low income were less likely to experience distress and psychiatric symptoms during the COVID-19 pandemic [12] . Another recent study from the US revealed that COVID-19-related financial stress was associated with a significantly increased likelihood of depression during pregnancy [73] . Implementing policies related to job security and stable income for pregnant women may serve as protective factors and improve their mental health.

Among the obstetric variables measured in the study, depressive symptoms were inversely correlated with gestational age and were positively correlated with a high-risk pregnancy. Pregnancy complications are well-known risk factors for postpartum and antenatal depression [74, 75] . Women who have a high-risk pregnancy should be considered at risk for depression, especially during the COVID-19 pandemic. Our findings, which show increased levels of depression earlier in pregnancy, are not in line with research reporting higher levels of depression towards the end of the pregnancy [76] . Interestingly, a recent longitudinal study of 135 pregnant women showed an increase in depressive symptoms after COVID-19 compared to measurements before the pandemic started. However, the levels of depressive symptoms after COVID-19 were as high as those during early pregnancy [77] . It is unclear whether depression levels earlier in pregnancy in our cohort were related to the unique circumstances of the initial stages of the pandemic, or rather reflect a possible rise in depression symptoms during the beginning of pregnancy. Further research is needed to confirm and understand the results regarding the relation between gestational age and depressive symptoms.

Depression scores among pregnant women were predicted by several factors related to the pandemic. First, women believing they have COVID-19 (even without being diagnosed) was associated with a higher depressive symptoms score. Second, the Preparedness Stress score predicted a greater likelihood of depressive symptoms, indicating that women who were worried about being unprepared for the birth due to the pandemic were more likely to experience depressive symptoms. In line with these results, a recent study of women who were pregnant during the COVID-19 pandemic found that higher depressive symptoms were associated with more concerns about not getting the necessary prenatal care [21] . We also found that the pandemic-related positive appraisal score reflected resilience, as it was inversely associated with the depressive symptoms score. The transition to motherhood is an opportunity for personal growth and finding meaning in life and gratitude [78] . Positive appraisal, in other words, focusing on the "positive aspects of a stressful situation when one possesses the intrapersonal and tangible resources that help to ensure a favorable outcome" [79] , has been shown to be predictive of lower distress levels in pregnant women [79, 80] . Having a positive attitude towards the effects of the pandemic on a woman's pregnancy and expected birth may represent a coping mechanism, which allows women to cope and adjust to the major life change they are about to undergo. Implementing psychotherapeutic interventions that enhance the use of positive appraisal and changes in maladaptive cognitive processes may contribute to reducing perinatal depressive symptoms during the pandemic.

There are several limitations to this study. First, the study was conducted online with self-report questionnaires. However, this enabled the recruitment of a large number of women during a short period of time, which was crucial in light of the rapidly progressing situation worldwide. Second, it should be noted that this is a cross-sectional study, which provides a snapshot of the mental health of women in May 2020. During that time, there was a relatively small number of COVID-19-related infections and death cases (an average of 2.188 new infections and 0.233 new death cases per million people per day [81] ). However, the lockdown and movement restrictions applied, as well as the uncertainty regarding the influence of the COVID-19 pandemic worldwide, created an atmosphere of stress and anxiety. The results may not necessarily signify a direct causal association between pregnancy and resilience, but rather suggest that other factors that are related to pregnancy, such as social connection and support, may mediate the relationship between pregnancy and resilience. Future stages of the current study and other studies will be able to evaluate the course of mental health symptoms and their sequela throughout the pandemic. Third, this type of self-selected sampling could be biased because most participants were born in Israel, married, and secular, limiting the generalizability of our results. The pandemic has disproportionately impacted racial minorities and lower-income families [82] , which are underrepresented in our cohort. Moreover, more severely depressed women are probably less likely to go online and be willing to participate in a study. Lastly, PHQ-2 may not be ideal for the assessment of depression during pregnancy, as there are different instruments that specifically address anxiety and depression during the perinatal period. However, this instrument was chosen as it is a concise and internationally validated screening tool for depression [43, 56, 83, 84] . The psychometric properties are good and show that a negative response to the PHQ-2 rules out depression efficaciously [45] . The major strength of this study is the relatively large cohort that was recruited over a short period of time, facilitating the investigation of the specific effects of COVID-19-pandemic-related variables.

Being pregnant may operate as a protective factor against depressive symptoms during a time of crisis, such as the COVID-19 pandemic. Increased social support, engaging in more health behaviors and applying positive appraisal are related to enhanced resilience from depression during pregnancy. Future studies that compare pregnant versus non-pregnant women could clarify the role of pregnancy on women's mental health during times of hardship. Furthermore, studies would benefit from distinguishing between experiences of depression and anxiety that call for professional help, as opposed to cases in which some degree of sadness, anxiety, fear, anger, and short-term adjustment issues are reasonable and even expected responses [85] . As the pandemic continues, prospective follow-up of women through the perinatal period may yield more information regarding the differential effects of stress during pregnancy and postpartum and should identify the mechanisms of mental health effects of COVID-19. Promoting economic policies and psychosocial interventions to protect pregnant women during the COVID-19 pandemic is essential to ensure positive long-term outcomes and minimize societal and gender gaps.

Supplementary Materials: The following are available online at https://www.mdpi.com/article/ 10.3390/ijerph18084298/s1, Table S1 : Pearson correlations of study variables among pregnant and non-pregnant women, Table S2 : Pearson correlations of study variables among pregnant women. Table S3 : Propensity-score matching using a combination of age and education-Stata output, Table  S4 : Propensity-score matching using a combination of age, education, income and employment status-Stata output. Figure S1 : COVID-19 Related Thoughts in Pregnancy (Preis, Mahaffey, and Lobel, 2020), Figure S2 : Propensity-score matching using a combination of age and educationevaluating balancing of the data, Figure S3 : Propensity-score matching using a combination of age, education, income and employment status-evaluating balancing of the data. Informed Consent Statement: Informed consent was obtained from all subjects involved in the study.

The datasets used and/or analyzed during the current study are available from the corresponding author upon request.

Impact of COVID-19 pandemic on mental health in the general population: A systematic review

Prevalence of stress, anxiety, depression among the general population during the COVID-19 pandemic: A systematic review and meta-analysis. Glob. Health

Mental health before and during the COVID-19 pandemic: A longitudinal probability sample survey of the UK population

Vulnerability and resilience to pandemic-related stress among U.S. women pregnant at the start of the COVID-19 pandemic

Disasters and Perinatal Health: A Systematic Review

Increased Levels of Depressive Symptoms among Pregnant Women in The Netherlands After the Crash of Flight MH17

The Fukushima Nuclear Accident Affected Mothers' Depression but Not Maternal Confidence

Peritraumatic Distress Mediates the Effect of Severity of Disaster Exposure on Perinatal Depression: The Iowa Flood Study

Surveys of postpartum depression in Miyagi, Japan, after the Great East Japan Earthquake

Resilience after Hurricane Katrina among pregnant and postpartum women

Psychosocial distress among women following a natural disaster in a low-to middle-income country: "healthy mothers, healthy communities" study in Vanuatu

Uptrend in distress and psychiatric symptomatology in pregnant women during the coronavirus disease 2019 pandemic

Perinatal depressive and anxiety symptoms of pregnant women during the coronavirus disease 2019 outbreak in China

Psychological impact of COVID-19 quarantine measures in northeastern Italy on mothers in the immediate postpartum period

COVID-19 pandemic and maternal mental health: A systematic review and meta-analysis

Maternal depressive and anxiety symptoms before and during the COVID-19 pandemic in Canada: A longitudinal analysis

The prevalence of psychiatric symptoms of pregnant and non-pregnant women during the COVID-19 epidemic

2019-nCOV distress and depressive, anxiety and OCD-type, and eating disorder symptoms among postpartum and control women

The positive effects of covid-19

Distinguishing postpartum and antepartum depressive trajectories in a large population-based cohort: The impact of exposure to adversity and offspring gender

Elevated depression and anxiety symptoms among pregnant individuals during the COVID-19 pandemic

Effects of Gonadal Steroids in Women with a History of Postpartum Depression

Suicide: The leading cause of maternal death

Depression: Is pregnancy protective? J. Women's Health

Physiological stress reactivity in human pregnancy-A review

Physiological reactivity to psychological stress in human pregnancy: Current knowledge and future directions

Estrogen Supplementation Attenuates Glucocorticoid and Catecholamine Responses to Mental Stress in Perimenopausal Women1

Estradiol Therapy After Menopause Mitigates Effects of Stress on Cortisol and Working Memory

A meta-analysis of the effectiveness of yoga-based interventions for maternal depression during pregnancy

Coping Styles in Pregnancy, Their Demographic and Psychological Influences, and Their Association with Postpartum Depression: A Longitudinal Study of Women in China

Resilience and psychological distress in pregnant women during quarantine due to the COVID-19 outbreak in Spain: A multicentre cross-sectional online survey

A Mixed-Methods Pilot Study of Perinatal Risk and Resilience During COVID-19

Pandemic-related pregnancy stress and anxiety among women pregnant during the COVID-19 pandemic

The Impact of Maternal Depression during Pregnancy on Perinatal Outcomes

Neonatal Outcomes in Women with Untreated Antenatal Depression Compared With Women Without Depression

Untreated depression during pregnancy: Short-and long-term effects in offspring. A systematic review

Antenatal maternal stress and long-term effects on child neurodevelopment: How and why?

Pregnancy-specific stress, prenatal health behaviors, and birth outcomes

Conceptualization, measurement, and effects of pregnancy-specific stress: Review of research using the original and revised Prenatal Distress Questionnaire

Adverse Perinatal Outcomes Predicted by Prenatal Maternal Stress among U.S. Women at the COVID-19 Pandemic Onset

Psychometric properties of the Pandemic-Related Pregnancy Stress Scale (PREPS)

The Patient Health Questionnaire-2: Validity of a two-item depression screener

Validation and utility of a self-report version of PRIME-MD: The PHQ Primary Care Study

Epidemiological evaluation of the Patient Health Questionnaire-2 in a pregnant population

German Screen for Child Anxiety Related Emotional Disorders (SCARED): Reliability, validity, and cross-informant agreement in a clinical sample

Pandemic-related pregnancy stress assessment-Psychometric properties of the Polish PREPS and its relationship with childbirth fear

The German version of the pandemicrelated pregnancy stress scale: A validation study

A Brief Measure for Assessing Generalized Anxiety Disorder

Diagnostic Validity of the Generalized Anxiety Disorder-7 (GAD-7) among Pregnant Women

Validation of the 7-item Generalized Anxiety Disorder scale (GAD-7) as a screening tool for anxiety among pregnant Chinese women

IBM. IBM SPSS Statistics 23. Release Notes

Software for Statistics and Data Science; STATA: College Station

KMATCH: Stata module for multivariate-distance and propensity-score matching, including entropy balancing, inverse probability weighting, (coarsened) exact matching, and regression adjustment

Validity and Utility of the Patient Health Questionnaire (PHQ)-2 and PHQ-9 for Screening and Diagnosis of Depression in Rural Chiapas, Mexico: A Cross-Sectional Study

Immediate Psychological Responses and Associated Factors during the Initial Stage of the 2019 Coronavirus Disease (COVID-19) Epidemic among the General Population in China

Risk for Depressive Symptoms among Hospitalized Women in High-Risk Pregnancy Units during the COVID-19 Pandemic

Rates and risk of postpartum depression-A meta-analysis

Social Support-A Protective Factor for Depressed Perinatal Women?

Perceived partner support in pregnancy predicts lower maternal and infant distress

Chronic stressors, social support, and depression during pregnancy

Psychological responses of pregnant women to an infectious outbreak: A case-control study of the 2003 SARS outbreak in Hong Kong

Psychological impact and social support in pregnant women during lockdown due to SARS-CoV2 pandemic: A cohort study

Exercise for depression (Review)

A meta-meta-analysis of the effect of physical activity on depression and anxiety in non-clinical adult populations

The evidence for physical activity in the management of major mental illnesses

Impact of prenatal exercise on both prenatal and postnatal anxiety and depressive symptoms: A systematic review and meta-analysis

Moms Are Not OK: COVID-19 and Maternal Mental Health. Front. Glob. Womens Health

Pregnant women's daily patterns of well-being before and during the COVID-19 pandemic in Finland: Longitudinal monitoring through smartwatch technology

Maternity Rights in Workplace

Workplace Rights of Pregnant Women and Their Spouses

COVID-19-related financial stress associated with higher likelihood of depression among pregnant women living in the United States

Identifying the women at risk of antenatal anxiety and depression: A systematic review

Special features of high-risk pregnancies as factors in development of mental distress: A review

Systematic Review of Prevalence of Antepartum Depression during the Trimesters of Pregnancy. Open Access Maced

Mental health of pregnant and postpartum women in response to the COVID-19 pandemic

Making existential meaning in transition to motherhood-A scoping review

Pregnancy-specific coping and changes in emotional distress from mid-to late pregnancy

Impact of Uncertainty, Social Support, and Prenatal Coping on the Psychological Well-being of High-risk Pregnant Women

Israeli Ministry of Health Basket

COVID-19 and Racial/Ethnic Disparities

A comparison of the PHQ-2 and MGMQ for screening for emotional health difficulties during pregnancy

Detecting and monitoring depression with a two-item questionnaire (PHQ-2)

Not all trauma is the same

We are grateful to H.P., Brittain Mahaffey and Marci Lobel for initiating this international research collaboration. K.Y. would like to thank the Azrieli Foundation for the award of an Azrieli Fellowship.

The authors declare no conflict of interest.