key: cord-1022903-pp75dwfp
authors: Franchini, Massimo; Baldanti, Fausto; Percivalle, Elena; Ferrari, Alessandro; Biasi, Pietro; Liumbruno, Giancarlo Maria; Glingani, Claudia
title: Impact of pathogen reduction technology on neutralizing antibody titer in COVID-19 convalescent plasma
date: 2021-07-29
journal: Transfus Clin Biol
DOI: 10.1016/j.tracli.2021.07.006
sha: 90099cc7139748d7b98906fa321913c0eed81072
doc_id: 1022903
cord_uid: pp75dwfp

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PRT was then performed with the INTERCEPT processing system (Cerus Europe BV).

Immediately before and immediately after the viral inactivation procedure each CP unit underwent a plaque reduction neutralization test (PRNT), as described elsewhere [5] , 

Impact of pathogen-reduction technologies on COVID-19 convalescent plasma potency

Amotosalen and ultraviolet A light treatment efficiently inactivates severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in human plasma

Preservation of neutralizing antibody function in COVID-19 convalescent plasma treated using a riboflavin and ultraviolet light-based pathogen reduction technology

Impact of pathogen reduction methods on immunological properties of the COVID-19 convalescent plasma

Covid-Plasma Task Force. Mortality reduction in 46 severe Covid-19 patients treated with hyperimmune plasma. A proof of concept single arm multicenter trial

The authors declare no conflicts of interest.Page 5 of 7 J o u r n a l P r e -p r o o f