key: cord-1021150-zf569xy1
authors: Rostami, Mojtaba; Shirani, Kiana; Haghighipour, Somayeh; Yazdani, Mohammad Reza
title: What was said about COVID-19 and what we heard and what we saw!
date: 2021-09-30
journal: J Res Med Sci
DOI: 10.4103/jrms.jrms_948_20
sha: bfe006e718b4a5f992f7c12f3f9b31a21d10b3cc
doc_id: 1021150
cord_uid: zf569xy1

nan

What was said about COVID-19 and what we heard and what we saw! Dear Editor, We reviewed the literature, searching about the followings and compare them to our local clinical findings, came to few local differences.

1. What has been said and done, about the means of transmission:

In the early days of pandemic, nearly everything was accused as presumptive transmission objects, and disinfection protocols on a large scale were designed and use of too many detergent materials got so extended that, they could be themselves a health hazard. [1] Humanity may be in fight and involve for a long time with coronavirus and others. Exaggerated and unnecessary prophylactic programs may cause the waste of health system deposits and staff energy. We have to see the most important ways of transmission and make prophylactic measures easier and much more practical. Now believing that only human breathing and close proximity are the main modes of transmission.

2. Regarding the high-risk groups, pregnancy [2] , cardiac diseases, immunosuppression, obesity, and chronic kidney diseases, long-standing diabetes mellitus [3] , Chronic obstructing pulmonary disease and hypertension along with age over 60 years have been accepted as high risk medical conditions. [4] What we saw in addition to the above, but still unanswered:

We encountered young patients who did not have any of the defined risk factors, but became severely ill and died. We think that, they are the unluckiest group, who do not have any of the above defined risk factors but may have other possibilities for catching intense disease:

• Perhaps, the immune system of this group, never have come in touch with any of the strains of the corona group. Hence, there is no known antigen fragments to be presented to immune system in the initial encounter • Or these patients received a high dose of the virus in the first encounter, supposed up to now these people, mostly are among health care givers • May it be genetic predisposition or possibility of diversity in the virus subtype? All the above options

SARS-CoV-2 viral load in upper respiratory specimens of infected patients

Why are pregnant women susceptible to COVID-19? An immunological viewpoint

COVID-19, diabetes mellitus and ACE2: The conundrum

Chronic kidney disease is associated with severe coronavirus disease 2019 (COVID-19) infection

Making sense of the cytokine storm: A conceptual framework for understanding, diagnosing, and treating hemophagocytic syndromes