key: cord-1019038-vt0vhd4j
authors: Zandi, Milad; Behboudi, Emad; Soltani, Saber
title: Can seasonal influenza vaccine for 2019/2020 has cross reactivity with some of SARS-CoV-2 proteins?
date: 2021-07-26
journal: Int J Infect Dis
DOI: 10.1016/j.ijid.2021.07.053
sha: 26ea273572278870e75d4cb11f59471810c0ce51
doc_id: 1019038
cord_uid: vt0vhd4j

nan

International Journal of Infectious Diseases, the authors stated that SARS-CoV-2 has hemagglutinine esterase (HE) glycoprotein and also suggested that the seasonal influenza vaccine for 2019/2020 which contained three or four strains of influenza A and B viruses may have cross reactivity with some of SARS-CoV-2 proteins (1). While the proteins of these two different viruses are not the same.

SARS-CoV-2 and influenza viruses are both enveloped, with an encapsidated single-stranded RNA genome. However, their genomes vary in the term of polarity and segmentation. Influenza In conclusion SARS-CoV-2 like SARS-CoV lacks HE gene (7) (8) (9) and it has four structural proteins spike (S), envelope (E), nucleoprotein (N) and membrane (M) (10), therefore, seasonal influenza vaccine for 2019/2020 cannot have cross reactivity with some of SARS-CoV-2 proteins.

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