key: cord-1018863-qdvhpjf6 authors: Naude, Dr D.F. title: Concern over reporting in the following review article date: 2021-10-12 journal: Explore (NY) DOI: 10.1016/j.explore.2021.10.001 sha: ffd0cb00cf7c5f80bdda783e2de0e274387a5197 doc_id: 1018863 cord_uid: qdvhpjf6 nan This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Re: Concern over reporting in the following review article: Alschuler, L., Weil, A., Horwitz, R., Stamets, P., Chiasson, A., Crocker, R., Maizes, V. 2020. Integrative considerations during the COVID-19 pandemic. Explore.000. 1-3. I refer to pg. 2, column 1 of the above-mentioned article specifically the section titled: [1] [2] [3] [4] [5] on this topic since 1997confirms that Echinacea purpurea provides substantial anti-inflammatory (down regulation of IL1-β, IL-6, IL-12 and TNF-α)action and also shows the inclusion of the upper parts and roots of E. purpurea extractions are essential for the anti-inflammatory effect. In this regard it appears that the authors have unfortunately omitted the latest data on this topic and referenced a single, dated study utilising an extract produced from above-ground parts only. Synergistic immunomopharmacological effects of N-alkylamides in Echinacea purpurea herbal extracts Echinacea alkylamides modulate TNF-α gene expression via cannabinoid receptor CB2 and multiple signal transduction pathways Effects of Echinaforce® treatment on ex vivo-stimulated blood cells Echinacea as an antiinflammatory agent: the influence of physiologically relevant parameters Induction of multiple pro-inflammatory cytokines by respiratory viruses and reversal by standardized Echinacea, a potent antiviral herbal extract The effect of Echinacea spp. on the prevention or treatment of COVID-19 and other respiratory tract infections in humans: A rapid review Botanical drugs and supplements affecting the immune response in the time of COVID-19: Implications for research and clinical practice Cone Purple Flower (Echinacea purpurea.) Effect on Respiratory Viral Infections (Brief Review Study): Could it be a Possible Solution to SARS-COV-2 and Other Viral Infection Pandemic Lockdown? EC Pulmonology and Respiratory Medicine 2020 Use of Echinaforce to Prevent Coronavirus Infections EC Microbiology Special Issue In vitro virucidal activity of Echinaforce®, an Echinacea purpurea preparation, against coronaviruses including common cold coronavirus 229E and SARS-CoV-2. Virology Declaration: S.A Natural Products is a distributer of complementary medicines and health supplements in South Africa including Echinacea products.