key: cord-1018719-dib64klk authors: Castellano, Antonella; Anzalone, Nicoletta; Pontesilli, Silvia; Fominskiy, Evgeny; Falini, Andrea title: Pathological brain CT scans in severe COVID-19 ICU patients date: 2020-08-29 journal: Intensive Care Med DOI: 10.1007/s00134-020-06222-z sha: 29bcbc44c8fc3ddff285ba7c315768e814282149 doc_id: 1018719 cord_uid: dib64klk nan Dear Editor, Neurologic involvement in patients with COVID-19 has been recently reported, with central nervous system symptoms being more common in patients with severe infection [1] . Accordingly, preliminary brain MRI findings in patients in the intensive care unit (ICU) have been described in a cohort of 27 patients with neurologic symptoms in a multi-center setting [2] . However, no data have yet been reported on brain computed tomography (CT) findings in COVID-19 patients in the ICU, and the relationship between acute imaging abnormalities, respiratory failure severity and alteration of laboratory parameters has not been investigated yet. Here we report a single-center retrospective analysis on brain CT findings in 23 patients with COVID-19 infection (21 M, 2F, mean age 60.2 ± 7.9 years), admitted to the two mobile ICUs at our hospital. All patients received invasive mechanical ventilation, six of them had venovenous extracorporeal membrane oxygenation (VV-ECMO). As soon as clinical state allowed, both chest and brain CT in one run were performed. Brain CT scans demonstrated acute lesions in 9 out of 23 cases (39%), with imaging findings being highly consistent throughout all the studies. Multifocal, linear hyperdensities suggestive for hemorrhages, involving both the cortex and the adjacent subarachnoid space, were evident in seven out of nine cases (30% of all the patients), with very subtle superficial enhancement after contrast administration (Fig. 1) . The remaining two cases (8.6%) showed cortical-subcortical areas of hypoattenuation with sulcal effacement, consistent with acute-subacute ischemia, with hemorrhagic transformation in one case (4.3%). CT-positive patients had significantly higher C-reactive protein (173.4 vs. 64 mg/L, p = 0.002) and elevated D-dimer (2.96 vs. 1.54 µg/mL, p = 0.018) than CT-negative patients. Moreover, a significantly lower PaO 2 /FIO 2 ratio was observed in brain CT-positive patients (116 vs. 161, p = 0.033) (see Electronic Supplementary Material, e- Table 1 and e- Fig. 1 ). Age and time intervals (from symptoms' onset and from ICU admission to brain CT), as well as other laboratory parameters recorded on the day of brain CT (FiO 2 , minimum and maximum PaO 2 and PaCO 2 , LDH, ferritin, white blood cell count, platelet count, PT, and aPTT), were not significantly different in the two groups of the patients (see Electronic Supplementary Material, e- Table 1 and e- Fig. 1 ) . No significant associations were observed between the presence of pathological neuroradiological findings and medical comorbidities, use of VV-ECMO, presence of risk factors for intracranial hemorrhage, and chest CT evidence of pulmonary embolism (e- Fig. 2 ). The percentage and absolute volume of well-aerated lung obtained at chest CT tend to be lower in brain CT positive patients, without reaching significance (e- Fig. 1 and e- Table 1 ). No significant associations were found between positive brain CT and the provided anticoagulant therapy (e- Fig. 2) , even if the association with anticoagulation itself cannot be evaluated since all patients had therapeutic-intensity anticoagulation according to the local hospital protocol. At the time of this analysis, 16 weeks after ICU admission, 66.7% of patients with positive brain CT have died versus 35.7% of patients with normal brain CT (p = 0.147). In conclusion, we noted a high percentage of abnormal brain CT studies in ICU patients with severe COVID-19 infection. Such abnormalities were hemorrhagic in most of the cases, highly consistent across patients, and related to worse P/F ratio and higher inflammatory indexes. The superficial distribution of hemorrhagic lesions is unusual and clearly different from white matter microhemorrhages described after severe lung failure [3] . We speculate on the occurrence of a diverse mechanism in COVID-19 patients, possibly related to endothelial damage [4] , resulting in impaired microcirculatory function and vascular fragility with microhemorrhages, or thrombotic microangiopathy [5] , that may be supported by similar imaging findings recently reported in a small cohort of four critically ill patients [6] . The imaging picture could also be related to the occurrence of isolated cortical vein microthrombosis, considering the increased tendency to venous thrombosis in more severe COVID-19 cases. Due to the therapeutic-intensity anticoagulation common to all cases, it is not possible to make any conclusion on a possible impact of the anticoagulant therapy itself on the prevalence of brain CT hemorrhages in the studied cohort, particularly in the absence of sufficient evidence-based data on the topic at present. The association between abnormal brain CT and patients' outcome deserves further confirmation in a larger cohort of patients. The online version of this article (https ://doi.org/10.1007/s0013 4-020-06222 -z) contains supplementary material, which is available to authorized users. Neurologic manifestations of hospitalized patients with Coronavirus disease 2019 in Wuhan Brain MRI findings in patients in the intensive care unit with COVID-19 infection Critical illness-associated cerebral microbleeds Endothelial cell infection and endotheliitis in COVID-19 Microvascular COVID-19 lung vessels obstructive thromboinflammatory syndrome (MicroCLOTS): an atypical acute respiratory distress syndrome working hypothesis Neuroimaging findings in patients with COVID-19 We thank all the colleagues of the Intensive Care Unit of San Raffaele Hospital, especially Antonio Dell' Acqua for careful data collection and interpretation, and Alberto Zangrillo and Giovanni Landoni for their precious contribution to data interpretation. We thank Riccardo Leone for chest CT data revision and interpretation.