key: cord-1015608-cpkjb1na
authors: Kuchi Bhotla, Haripriya; Kaulb, Tanushri; Balasubramanian, Balamuralikrishnan; Easwaran, Murugesh; Anand Arumugam, Vijaya; Pappusamy, Manikantan; Saravanan, Muthupandian; Meyyazhagan, Arun
title: Platelets to surrogate lung inflammation in COVID-19 Patients
date: 2020-07-12
journal: Med Hypotheses
DOI: 10.1016/j.mehy.2020.110098
sha: f564987d57c9fad21764a68e7e54edea3e4c1160
doc_id: 1015608
cord_uid: cpkjb1na

The neoteric severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been jeopardizing the world with the symptoms of seasonal flu. The virus contagion predicted to have been originated from Wuhan, China has by far trapped 4,198,418 cases from 212 countries in the world with two international conveyances with 284,102 deaths as of 11 May 2020 (10:18 GMT). Researchers around the globe have indulged in deciphering viral mode in the body for devising a cure. Affirmations from autopsies and preliminary findings on SARS-CoV-2 hypothesized on viral pathogenesis within the host, for instance, source of inflammation in lungs and pneumonia. This hypothesis assigns the platelets as agents of infection after viral entry. Presently, curbing infection to stall the spread of SARS-CoV-2 is the prima facie intervention employed, worldwide. However, public health authorities must monitor the state of affairs scrupulously, as the deeper our understanding of this novel virus and its associated outbreak, the better we can deal with it. Knowing this idea might be far-fetched, yet this postulate would serve as the groundwork for the present situation.

27 Abstract:

The neoteric severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been 29 jeopardizing the world with the symptoms of seasonal flu. The virus contagion predicted to 

Government Head Quarters Hospital

TK have done the literature search and drafted the paper. AM, BB, and 145 MS helped with the literature search and revised the manuscript. SC, MS put forward the 146 hypothesis and revised the manuscript. VA, PM, HKB, ME, AM and BB provided ideas about 147 the mechanism of platelet receptor interaction and revised the paper. All authors approved the : coronavirus of probable bat origin

WHO. Coronavirus disease 2019 (COVID-19) situation report -92

2019 novel coronavirus: where we are and what we know

Which lessons shall we learn from the 2019 novel coronavirus 176 outbreak?

Thrombocytopenia is associated with severe 178 coronavirus disease 2019 (COVID-19) infections: A meta-analysis

Platelets and infection -an emerging role of platelets in viral 181 infection

DC-SIGN and CLEC-2 mediate human 193 immunodeficiency virus type 1 capture by platelets

Mechanism of thrombocytopenia in COVID-19 patients

Multiple roles of the coagulation protease cascade during 199 virus infection

☒ The authors declare that they have no known competing financial interests or personal 203 relationships that could have appeared to influence the work