key: cord-1015363-oleg0wmt authors: Cattaneo, Chiara; Pagani, Chiara; Cancelli, Valeria; Imberti, Luisa; Roccaro, Aldo M.; Notarangelo, Luigi D.; Rossi, Giuseppe title: Reduction in the rate and improvement in the prognosis of COVID-19 in haematological patients over time date: 2020-08-07 journal: Leukemia DOI: 10.1038/s41375-020-01015-1 sha: c2a2edc2cfaddd5b1603ed3d6d5838abdc4840df doc_id: 1015363 cord_uid: oleg0wmt nan The risk of death was independent from the nature of the underlying haematological disease; however, patients on active treatment had a worse prognosis than those not requiring treatment. Given the paucity of knowledge about COVID-19 evolution, many investigators, government agencies and professional societies have drafted guidelines for patients with leukaemia and myeloid malignancies [8] , as well as for oncological and transplant patients [9, 10] . In general, it was suggested to limit unnecessary hospital visits and to balance the risk and benefit of administering potentially harmful treatment. As suggested, we have prioritized telehealth services and we have tried to defer or temporarily stop administration of cytostatic and immunosuppressive treatments, including consolidation treatments and transplants for patients in stable remission. The duration of treatment programmes has been shortened and maintenance treatments have been discontinued in responsive patients with indolent lymphoma. In addition, the fear of becoming infected during the pandemic has discouraged many patients from seeking in-hospital evaluation. Indeed, the number of patients with newly diagnosed haematological disease during the months of March and April 2020 dropped by 52% compared to the same period of 2019. Also, the number of first evaluations for urgent haematological problems decreased from 202 during January and February to 80 during March and April 2020. More recently, a significant decline in the number of new cases of COVID-19 has been observed in our region as well as in other countries. Since March 1st we have been collecting all cases of COVID-19 diagnosed by SARS-CoV-2 detection with reverse transcription-polymerase chain reaction-based assay on nasal and pharyngeal swab, occurring in haematological patients managed at our centre. As of June 2nd, a total of 137 patients with symptomatic SARS-CoV-2 infection have been detected. We have noted that the number of COVID-19 cases significantly declined after March also in haematological patients. In addition, we realized that even the severity of COVID-19 was declining in parallel. Therefore, we have analysed the fatality rate within the three cohorts of patients diagnosed with COVID-19 in March, April and May 2020, respectively. Clinical characteristics of the three cohorts do not show significant differences regarding age, sex, haematological diagnosis and disease status, as well as the proportion of patients undergoing active haematological treatment ( Table 1) . Need of oxygen treatment was similar in March and April cohorts; it was absent in the three patients observed in May. All patients were managed in COVID-dedicated units with the same therapies and respiratory support measures also adopted for non-haematological patients throughout the entire period. Out of 108 patients diagnosed in March, 40 (37%) died after a median of 5.5 days. In April, a diagnosis of COVID-19 was established in 26 patients, 4 of whom (19%) died, after a median of 17 days. Of note, all fatalities occurred by April 5th. Only three patients were diagnosed with COVID-19 in May, and none of them has died. Figure 1 shows the survival of the three cohorts as of June 2nd. These data would confirm that, in addition to a marked decrease in the number of patients infected, consistent with the global evolution of the pandemic, also the overall prognosis of COVID-19 has markedly improved. The survival of patients diagnosed in April versus March was significantly better, in spite of similar demographic and clinical features, including the need of oxygen supplementation at diagnosis. The fatality rate consistently reported by several authors during the peak of the pandemic has rapidly declined after March and has reached negligible levels after April 15th. There is much controversy about the potential causes of this phenomenon, including a reduction in viral inoculum or virulence, or as yet unrecognized causes. Nonetheless, should similar data be reported also by others, the criteria proposed for the management of haematological patients during COVID-19 may need to be revised in order to more properly balance the risk of COVID-19 with that of undertreating severe, potentially life-threatening haematological disorders. Moreover, with the reduction of pandemic burden, patients should also be encouraged to seek in-hospital evaluation in the presence of haematological abnormalities, since the risk of underestimating severe clinical problems may become actually higher than the risk of acquiring symptomatic COVID-19. Fig. 1 Survival of the three cohorts as of June 2nd. Survival of patients after acute COVID-19 diagnosed in March ( ), April ( ) or May 2020 ( ), respectively. Survival duration was calculated from the date of SARS-CoV-2-positive swab. The difference of survival probability between patients diagnosed in March versus April 2020 is significant (log-rank test: P = 0.03). scientific advisory board for Biogen and has received research funding from FISM Fondazione Italiana Sclerosi Multipla) and research support from Genzyme-Sanofi; A.M.R. reports grants from Associazione Italiana per la Ricerca sul Cancro, European Haematology Association, Fondazione Regionale per la Ricerca Biomedica, ERA-NET TRANSCAN-2, AstraZeneca, and other grants from Amgen, Celgene and Janssen, outside the submitted work; G.R. reports personal fees outside the submitted work from Celgene, Abbvie, Janssen, Jazz, Astellas, Daichii-Sankyo, Amgen and Roche Pfizer. All other authors declare no conflict of interest. Publisher's note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. 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The challenge of COVID-19 and hematopoietic cell transplantation; EBMT recommendations for management of hematopoietic cell transplant recipients, their donors, and patients undergoing CAR T-cell therapy Conflict of interest L.I. has received speaker honoraria from Biogen, Genzyme-Sanofi, Meck-Serono and Novartis, has participated to