key: cord-1009058-6l2okgxa authors: Garralda Fernandez, J.; Molero Vilches, I.; Bermejo Rodriguez, A.; Cano de Torres, I.; Colino Romay, E. I.; Garcia-Arata, I.; Jaqueti Aroca, J.; Lillo, R.; Lopez Lacomba, D.; Mazon Cuadrado, L.; Molina Esteban, L. M.; Morales Garcia, L. J.; Moratilla Monzo, L.; Nieto-Borrajo, E.; Pacheco Delgado, M.; Prieto Menchero, S.; Sanchez Hernandez, C.; Sanchez Testillano, E.; Garcia-Martinez, J. title: Impact of SARS-CoV-2 pandemic among health care workers in a secondary teaching hospital in Spain. date: 2020-07-29 journal: nan DOI: 10.1101/2020.07.26.20162529 sha: 3705c7e2c301c887c82d2b69d398702d74ad117a doc_id: 1009058 cord_uid: 6l2okgxa Background. The COVID-19 pandemic has posed a huge challenge to healthcare systems and their personnel worldwide. The study of the impact of SARS-CoV-2 infection among healthcare workers, through prevalence studies, will let us know viral expansion, individuals at most risk and the most exposed areas. The aim of this study is to gauge the impact of SARS-CoV-2 pandemic in our hospital workforce and identify groups and areas at increased risk. Methods and Findings. This is a cross-sectional and longitudinal study carried out on healthcare workers based on molecular and serological diagnosis of SARS-CoV-2 infection. Of the 3013 HCW invited to participate, finally 2439 (80.9%) were recruited, including 674 (22.4%) who had previously consulted at the OHS for confirmed exposure and/or presenting symptoms suggestive of COVID-19. A total of 411 (16.9%) and 264 (10.8%) healthcare workers were SARS-CoV-2 IgG and rRT-PCR positive, respectively. The cumulative prevalence considering all studies (IgG positive HCW and/or rRT-PCR positive detection) has been 485 (19.9%). SARS-CoV-2 IgG-positive patients in whom the virus was not detected were 221 (9.1%); up to 151 of them (68.3%) did not report any compatible symptoms nor consult at the OHS for this reason. Men became more infected than women (25% vs 18.5%, p=0.0009), including when data were also classified by age. COVID-19 cumulative prevalence among the HCW assigned to medical departments was higher (25.2%) than others, as well as among medical staff (25.4%) compared with other professional categories (p<0.01). Conclusions. Global impact of the COVID-19 pandemic on HCW of our centre has been 19.9%. Doctors and medical services personnel have had the highest prevalence of SARS-CoV-2 infection, but many of them have not presented compatible symptoms. This emphasizes the performance of continuous surveillance methods of the most exposed health personnel and not only based on the appearance of symptoms. The aim of this study is to gauge the impact of SARS-CoV-2 pandemic in our 87 hospital workforce and identify groups and areas at increased risk. consult at the OHS due to compatible symptoms with COVID-19 infection [11] . The longitudinal study was carried out from the appearance of the first 131 confirmed COVID-19 case in the hospital March 2, 2020 until May 13, and 132 included those HCW who consulted at the OHS for confirmed exposure and/or 133 presenting symptoms suggestive of COVID19 [11] , as registered in the OHS 134 database. For molecular detection of SARS-CoV-2 infection at least one 135 nasopharyngeal swab was obtained in viral transport medium and processed as 136 stated previously. All these symptomatic workers were also included in the cross-137 sectional study as participants. The following variables were collected from the participants in both studies: (Fig 2) , although these differences 217 were not significant (p=0.38). symptoms, but an IgG antibody has been detected. The cumulative prevalence of SARS-CoV-2 infection in our center has been 275 of 19.9 %. This proportion is significantly higher than that of the population in the 276 area in which the center is located (11.4%), as stated in the wide sero-277 epidemiological study ENE-COVID19(13), despite the fact that symptomatic 278 cases have followed a very similar onset kinetics (Fig 1) . It is very likely that there 279 has been a common source of contagion with that of the general population, but 280 also it is clear that there has also been a risk exposure, especially in the first days 281 of the outbreak when the virus situation was not exactly known and HCW were 282 not taking the appropriate protective measures [14] . Identification 373 of a novel coronavirus causing severe pneumonia in human Coronavirus Disease (COVID-19) Situation Reports The origin, 380 transmission and clinical therapies on coronavirus disease 2019 (COVID-381 19) outbreak-An update on the status Asymptomatic Carrier Transmission of COVID-19 The 388 incubation period of coronavirus disease 2019 (CoVID-19) from publicly 389 reported confirmed cases: Estimation and application Preliminary 392 prediction of the basic reproduction number of the Wuhan novel 393 coronavirus 2019-nCoV Protecting 395 healthcare personnel from 2019-nCoV infection risks: lessons and 396 suggestions Protecting our healthcare workers 399 during the COVID-19 pandemic Informe sobre la situación de COVID-19 en personal sanitario en España 402 Situación en Sanitarios a 21 de mayo 406 de 2020.pdf 407 10. Hospital Universitario de Fuenlabrada Unique epidemiological and clinical 412 features of the emerging 2019 novel coronavirus pneumonia implicate special control measures Instituto Salud Carlos III. National Study of SARS-CoV2 sero-419 Transmission of COVID-19 to Health Care Personnel During 423 Exposures to a Hospitalized Patient MMWR Morb Mortal Wkly Rep SARS-CoV-2-specific antibody detection in healthcare workers in 430 Germany with direct contact to COVID-19 patients Hospital-Wide SARS-CoV-2 Antibody Screening in 3056 Seroprevalence of antibodies against SARS-CoV-2 among health 438 care workers in a large Spanish reference hospital. medRxiv SARS-CoV-2 seroprevalence among all workers in a 442 teaching hospital in Spain: unmasking the risk. medRxiv Informe epidemiológico 445 semanal comunidad de madrid Prevalence of Asymptomatic SARS-CoV-2 Infection: 448 A Narrative Review CoV-2 Antibody Prevalence among Healthcare Workers Exposed to COVID-19 Patients Impact of COVID-19 Outbreak 455 on Healthcare Workers in Italy: Results from a National E-Survey. J 456 Community Health COVID-2019) Infection Among Health Care Workers and 460 Implications for Prevention Measures in a Tertiary Hospital Screening of healthcare workers for SARS-CoV-2 highlights the role of 466 asymptomatic carriage in COVID-19 transmission Transmission of 2019-NCOV infection from an asymptomatic contact 469 in Germany The impact of testing and 472 infection prevention and control strategies on within-hospital transmission 473 dynamics of COVID-19 in English hospitals COVID-19: 476 the case for health-care worker screening to prevent hospital 477 transmission Do Men Have a Higher Case Fatality 480 Rate of Severe Acute Respiratory Syndrome than Women Do? Epidemiol Hopkins Bloom Sch Public Heal All rights Reserv Sex-specific clinical 485 characteristics and prognosis of coronavirus disease-19 infection in 486 A retrospective study of 168 severe patients. PLoS 487 Pathog Mortality impacts of the coronavirus disease (COVID-19) outbreak 490 by sex and age: rapid mortality surveillance system Coronavirus COV-19/SARS-CoV-2 affects women 493 less than men: clinical response to viral infection Let's talk about sex in the context of 496 The covid-19 pandemic, personal protective equipment, and 500 respirator: a narrative review SARS-CoV-2 Infection in Health Care Workers: Cross-sectional 505 Analysis of an Otolaryngology Unit. Otolaryngol Neck Surg Analytical 509 performances of a chemiluminescence immunoassay for SARS Assessment of immune response to SARS-CoV-2 with fully automated 515 MAGLUMI 2019-nCoV IgG and IgM chemiluminescence immunoassays 516 De 517 Gruyter Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR