key: cord-1006130-t8emurha
authors: Alghamdi, Saleh
title: Clinical characteristics and treatment outcomes of severe (ICU) COVID-19 patients in Saudi Arabia: A single centre study
date: 2021-08-04
journal: Saudi Pharm J
DOI: 10.1016/j.jsps.2021.08.008
sha: eb404bbd85ac6b4a1eab36527e4a1f07f24f96ea
doc_id: 1006130
cord_uid: t8emurha

BACKGROUND: There is limited information describing the presenting features and treatment outcomes of intensive care unit (ICU) patients with coronavirus disease 2019 (COVID-19) in Saudi Arabia. OBJECTIVE: To investigates the clinical, epidemiological, laboratory, radiological, vital signs and treatment characteristics/outcomes of severe (ICU) COVID-19 patients in Albaha region, Saudi Arabia. METHODS: A retrospective cohort study was conducted from 01 April 2020 to 31 August 2020 involving files review of 171 patients admitted to the ICU of a COVID-19 treatment centre as a result of severe symptoms. RESULTS: Around a third of the ICU patients admitted were over 66 years of age, 59.6% males, 45% diabetics, 39% hypertensive, 25.7% smokers. Patients had symptoms such as 79% fever, 78% cough, 75% headache, 59% sore throat, 57% runny nose, and 75% cough. More than half of the patients had less than 90% oxygen saturation. Bilateral infiltration was present in about 43% of patients. 85.4% lymphopenia, and 70.8% D-dimer (>0.5 u/ml) were the most significant laboratory results. The median stay in the hospital ranged from 4 to 15.6 days, and the ICU time ranged from 4 to 12.7 days. Approximately 29% of patients received antiviral, antimalarial, and antibiotic treatment, while 27.5% of patients received antibiotics and antimalarial therapy alone. Incorporating hydroxychloroquine in treatment protocols did not improve patients’ outcomes. CONCLUSIONS: Older age and cardio-metabolic comorbidities increase the risks of sever COVID-19. Different treatment protocols fail to improve mortality rates and urgent efforts are required to prevent the disease and reduce its severity.

Globally, there are 109,555,318 confirmed cases of COVID-19 as of February 17, 2021, including 2,420,451 deaths (World Health Organization, 2020). The first confirmation case was Due to the different demographics, comorbidities and response of the immune system in the various populations, the seriousness of the disease appears variable. Pneumonia may be the most frequent manifestation of acute respiratory distress syndrome (ARDS). Other serious complications have been reported, including arrhythmia, septic shock, and multi-organ failure (Arentz et al., 2020; Chen et al., 2020) . Older persons with comorbidities and polypharmacy have a higher risk for drugs interactions, side effects, complications and high probability of viral infection (Hammad et al., , 2019b (Hammad et al., , 2019a (Hammad et al., , 2017 Mangi et al., 2020) .

Although numerous studies reported on the epidemiology and typical presentation of COVID-19 patients in Saudi Arabia (Alsofayan et al., 2020; Alyami et al., 2020; Shabrawishi et al., 2020) , regional data is still needed to improve emergency response planning and optimise the use of healthcare resources.

The aim of this study is to investigates the clinical, epidemiological, laboratory, radiological, vital signs and treatment characteristics/outcomes of severe (ICU) COVID-19 patients in Albaha region, Saudi Arabia.

A retrospective cohort study was conducted from 01 April 2020 to 31 August 2020 involving files review of 171 patients admitted to the ICU of a COVID-19 treatment centre in Albaha region as a result of severe symptoms. A list of all COVID-19 patients admitted to the ICU were obtained from the medical administration. Of those patients, 171 patients had a confirmed COVID-19 infection and were included in the study. Patients were confirmed as having the virus by positive SARS-CoV-2 nucleic acid results using a real-time reverse transcriptase-polymerase chain reaction (RT-PCR) assay on nasopharyngeal swab specimens.

A data collection form was developed as an Excel file to facilitate the data collection process that was done manually by trained hospital pharmacists that were trained by the investigator on how to collect the data from the hospital electronic medical records system. Demographics, laboratory, clinical, radiological and medications data were collected. Descriptive statistics were used for data analysis. Ethical approval was obtained from the Scientific and Research Committee at the hospital taking part in this study.

The data was expressed as an average value of ± SD value (standard deviation). Using SPSS software (version 20) to compare variables in the best protocols and co-morbidities, a one-way ANOVA statistical analysis was performed. To analyse categorical data, the X 2 test was implemented. To detect the relationship between the categorical variables, the Chi-square test was also used in order to compare the clinical features between patients with or without diabetes and with or without hypertension. The length of stay from the date of admission to the discharge/transfer date was recorded for all included patients. The median (IQR) length of stay is presented in tables (3&5). The Kruskal-Wallis analysis was used to compare the medians. P values were considered statistically significant if below 0.05.

About 32% of the admitted patients for ICU were above 65 years old, 60% males, 45% diabetic, 39% hypertensive, 26% smokers. The patients had symptoms as 79% fever, 78% cough, 75% headache, 59% sore throat and 57% runny nose. More the half of the patients had oxygen saturation less than 90%. About 43% of patients had bilateral infiltration as described in Table   1 . The most important laboratory findings were 85.4% lymphopenia, 70.8% D-dimer (>0.5 u/ml), 44.4% neutrophilia, and 41% eosinophilia as illustrated in Table 2 . The length of hospital stay ranged from 4 to 15.6 days and the time in ICU ranged from 4 to 12.7 days as presented in Table 3 . About 29% of the patients were prescribed antiviral, antimalarial and antibiotics therapy, and unfortunately 35% of those patients died. Around 27.5% of patients were prescribed antibiotics and antimalarial only, of which 13% passed away as shown in Table 4 .

We did not collect data on the factors affecting choice of treatment protocol, but the rationale for choosing triple therapy, the most aggressive protocol, was mainly based on the severity of patients' symptoms and clinicians' attempt, at the time, to kill the virus and reduce the damage it was causing in those severely ill patients. We observed no difference in the mortality rate between the protocol of therapy with or without hydroxychloroquine (P-value: 0.625) as described in Table 5 . The most prescribed medications were Paracetamol, Ceftriaxone, Azithromycin, Hydroxychloroquine, Enoxaparin, Omeprazole, vitamin D, Zinc, Methylprednisolone, and Dexamethasone as prescribed in Table 6 . 

This study explored the the clinical, epidemiological, laboratory, radiological, vital signs and treatment characteristics/outcomes of severe (ICU) COVID-19 patients in Albaha region, Saudi Arabia. We present further evidence to inform healthcare professionals, hospital administrators and public health practitioners of the profile of critically ill COVID-19 patients who are at high risk of admission to ICU.

Age ( Age alone is a significant factor for severe COVID symptoms (Barry et al., 2021; Centers for Disease Control and Prevention, 2021; Thomson et al., 2020) as it increases the risk of comorbidities, with complex polypharmacy issues and an aging immune system. Furthermore, while male and female patients are both at risk of severe infection requiring ICU admission, male gender has been highlighted as a significant risk factor in many Saudi (Alharthy et al., 2021; Alhumaid et al., 2021) and international studies (Peckham et al., 2020; Thomson et al., 2020) . This could be due the high risk of exposure due to socio-economic factors such as working and socializing patterns in a male-dominated society, and the impact of lockdown measures on the female population (particularly in relation to homeschooling), and the inherent immune differences in male vs, female individuals.

Smoking is another common feature among Saudi ICU patients. Smoking has been suggested to double the risk of severe COVID-19 symptoms (Gülsen et al., 2020) , and similar to our study, other studies (Alharthy et al., 2021; Caliskan and Saylan, 2020; Patanavanich and Glantz, 2020) also showed an increased risk of ICU admissions. This could be due to smokers having epithelial cells' damage in the lungs and respiratory comorbidities such as COPD.

Most patients admitted to ICU in our study had diabetes and/ or hypertension. Analysis by (Rawshani et al., 2021) found that type-2 diabetes was independently associated with a higher risk of hospital and ICU admissions and death from COVID-19. The mechanisms behind this are not fully elucidated but it is thought that immunomodulation/ suppression and hyperglycaemia provide a suitable environment for coronavirus to thrive (International Diabetes Federation, 2021). Hypertension in older patients is also associated with severe CVOVID-19, especially if the patient also has myocardial injury and an established cardiovascular disease Williamson et al., 2020) . Our findings are similar to reports by (Alharthy et al., 2021; Barry et al., 2021; Richardson et al., 2020; Thomson et al., 2020) , where diabetes and/or hypertension were the most common comorbidities for COVID-19 ICU patients.

Lymphopenia (an abnormally low number of blood lymphocytes) is the most common laboratory finding in COVID-19 and is observed in as many as 83 percent of hospitalized patients. Neutrophilia, elevated serum alanine aminotransferase and aspartate aminotransferase levels, elevated lactate dehydrogenase, high CRP and high ferritin levels may be associated with higher disease severity. Elevated D-dimer and lymphopenia were associated with high mortality rate. Procalcitonin is normally common upon entry, but may increase among those admitted to the ICU. Patients with serious illness had elevated plasma levels of inflammatory drugs, indicating possible immune dysregulation (Kermali et al., 2020; Mardani et al., 2020) . These presentations have also been reported in other studies (Alharthy et al., 2021; Barry et al., 2021; Casas-Rojo et al., 2020; Gadhiya et al., 2021) .

In the severe COVID-19 illness; patients have respiratory frequency >30 breaths per minute, SpO2 <94 percent at sea level in the room air, ratio of arterial partial oxygen pressure to fraction of inspired oxygen (PaO2/FiO2) <300 mmHg, or pulmonary infiltration >50 percent. However, in the critical COVID-19 disease; patients have respiratory failure, septic shock, and/or multiple dysfunctions of the organ. The median time to dyspnea from the onset of disease or symptoms for patients who experienced serious disease ranged from 5 to 8 days, the median time to acute respiratory distress syndrome (ARDS) from the onset of disease or symptoms ranged from 8 to 12 days, and the median time to admission to ICU from the onset of disease or symptoms ranged from 10 to 12 days. Clinicians should be mindful that certain patients have the potential to deteriorate rapidly one week after the onset of the disease (Diamond et al., 2020) . Our findings are within the ranges reported in the study by (Alwafi et al., 2021; Rees et al., 2020; Schmidt et al., 2021) . The differences observed across countries and regions may be due to the varying local admission and discharge criteria. , 2021) . However, at the start of the pandemic (when this study was carried out), the treatment protocols included a number of antibiotics and antimalarials such as hydroxychloroquine that were suggested at the time to improve outcomes for patients. As evidence continued to emerge, treatment protocols were updated accordingly to reflect the latest evidence (Jomah et al., 2020) . We have previously identified no impact of hydroxychloroquine on patients' outcomes . A systematic review by (Chedid et al., 2021) found that using a cocktail of antibiotics especially earlier on in the pandemic was highly prevalent, despite the lack of efficacy in COVID-19

infections. However, evidence supporting the use of dexamethasone for example resulted in its use to manage covid-19 infections in hospitals across the world (Auwaerter, 2020; Bhimraj et al., 2020) .

The evidence for efficacious interventions, once a COVID-19 infected person is admitted to hospital, are still emerging. However, the clinical features and parameters of patients of high risk of infection, admission and staying longer in hospital are starting to strengthen. Our study adds to the current knowledge of patients at risk of developing severe COVID-19 symptoms, and highlights the manifestation of these symptoms to improve resource planning in hospitals treating those patients.

The pathogenesis and etiology of COVID-19 remains unknown to date, and targeted therapies for COVID-19 patients are not yet available, with the exception of empirically symptomatic therapies for critically ill patients. Scientists around the world should work together to find successful COVID-19 therapies. Understanding patients' demographics and characteristics of COVID-19 presentation should feed into efforts for disease prevention.

Committee at the hospital taking part in this study.

The author declares no conflict of interest.

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Clinical characteristics and treatment outcomes of severe (ICU) COVID-19 patients in Saudi Arabia: A single centre study