key: cord-0998967-to4zn9da
authors: Abdelmaksoud, Ayman; Goldust, Mohamad; Vestita, Michelangelo
title: Comment on “Cutaneous Manifestations of Covid 19: A Case Report & a new finding from Egypt”
date: 2020-08-02
journal: Dermatol Ther
DOI: 10.1111/dth.14120
sha: ac7e0f33f92f27e37454c4ea5ad070d1ea4d700e
doc_id: 998967
cord_uid: to4zn9da

nan

Dear Editor,

We read with interest a case report by Farouk and This article is protected by copyright. All rights reserved.

Cutaneous signs or rashes in association with COVID-19 pandemic are polymorphic, mostly include erythema, chilblain-like and urticarial lesions, with varied incidence rate between nations. Petechial and purpuric changes have also been described. Interestingly, a strong early SARS-CoV-2-induced type I IFN response is associated with early viral clearance and a mild course of the disease, whereas an insufficient type I IFN response may be associated with progression to more severe disease. 8, 9 In other words and according to the type I IFNs response, SARS-CoV2 infection had induced a massive "inflammatory storm" associated with hematogenous dissemination of the virus to a possibly HPV-loaded keratinocytes. The later had showed a higher degree of differentiation and proliferation resulting in a warty lesions. This hypothesis may be considered for wart and wart-like lesions that may entail HPV antigens.

Unfortunately, Farouk and Sadek 1 had not obtained a skin biopsy for the "wart-like"

Cutaneous Manifestations of Covid 19: A Case Report & a new finding from Egypt

Reply to "COVID-19 can present with a rash and be mistaken for dengue": petechial rash in a patient with COVID-19 infection

COVID-19 and cutaneous manifestations: A systematic review

Plasmacytoid dendritic cells and type I interferon in the immunological response against warts

Imbalanced host response to SARS-CoV-2 drives development of COVID-19